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https://www.readbyqxmd.com/read/28628504/morphology-and-function-of-meibomian-glands-and-other-tear-film-parameters-in-junior-high-school-students
#1
Takanori Mizoguchi, Reiko Arita, Shima Fukuoka, Naoyuki Morishige
PURPOSE: We measured tear film parameters, including the morphology and function of meibomian glands, in junior high school students at 15 years of age. METHODS: A total of 111 eyes of 111 students (56 males and 55 females) were enrolled in the study. The ocular symptom score (0-14), after-school study time, lipid layer thickness (LLT) of the tear film, partial blink rate, lid margin abnormalities (0-4), tear film breakup time, corneal and conjunctival epithelial damage (fluorescein staining score, 0-9), meiboscore as determined by noncontact meibography (0-6), Schirmer test value, and meibum grade (0-3) were determined...
June 14, 2017: Cornea
https://www.readbyqxmd.com/read/28627956/evaluating-the-effects-of-botulinum-toxin-a-on-tear-metrics-in-patients-with-hemifacial-spasm
#2
Yasmin Poustchi Mali, Robert L Schultze, Edward J Wladis
Hemifacial spasm has been previously shown to result in dry eye and ocular surface diseases. This study was performed to assess the impact of chemodenervation with botulinum toxin on clinically-relevant metrics of tears. Tear osmolarity and lipid layer thickness were measured in patients with hemifacial spasm after they achieved relief from hemifacial spasm via botulinum toxin injections. Twelve eyes of 6 patients with hemifacial spasm (2 men and 4 women; mean age 55.5 years) were assessed in accordance with the Declaration of Helsinki and IRB approval...
June 19, 2017: Orbit
https://www.readbyqxmd.com/read/28615923/changes-in-meibomian-gland-morphology-and-ocular-higher-order-aberrations-in-eyes-with-chalazion
#3
Shima Fukuoka, Reiko Arita, Rika Shirakawa, Naoyuki Morishige
PURPOSE: To examine the changes in meibomian gland morphology and ocular higher-order aberrations (HOAs) in eyes with chalazion and its excision. METHODS: Seven male patients with previous history of chalazion excision and seven control male subjects were enrolled. Changes in meibomian gland morphology (meiboscores, gland dropout, and shortening) were evaluated by using meibography equipped in a wavefront analyzer KR-1W and in a slit-lamp device BG-4M. Ocular HOAs were measured sequentially with KR-1W...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28615806/proposal-of-a-new-classification-scheme-for-periocular-injuries
#4
Devi Prasad Mohapatra, Friji Meethale Thiruvoth, Ravi Kumar Chittoria, S Dinesh Kumar, Sudhanva Hemant Kumar, Senthil Kumar, Preethitha Babu, Elan Kumar
BACKGROUND: Eyelids are important structures and play a role in protecting the globe from trauma, brightness, in maintaining the integrity of tear films and moving the tears towards the lacrimal drainage system and contribute to aesthetic appearance of the face. Ophthalmic trauma is an important cause of morbidity among individuals and has also been responsible for additional cost of healthcare. Periocular trauma involving eyelids and adjacent structures has been found to have increased recently probably due to increased pace of life and increased dependence on machinery...
January 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/28612893/the-mixture-of-bifidobacterium-associated-with-fructo-oligosaccharides-reduces-the-damage-of-the-ocular-surface
#5
G Chisari, E M Chisari, A Francaviglia, C G Chisari
BACKGROUND: Despite its high prevalence Dry Eye Syndrome (DES) in frequently under-recognized owing to its negative influence on patients visual function. METHODS: This clinical trial was a pilot study to evaluate the effects of supplementation with mixture (Bifidobacterium lactis and Bifidobacterium bifido) on the tear film. Following the run-in period subjects were randomized in two groups: group A (N°20 subjects) and group B (N°20 subjects). Group A (control) treated only with substitute tear and group B treated with substitute tear + mixture (symbiotic)...
May 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28604356/ocular-surface-temperature-in-patients-with-evaporative-and-aqueous-deficient-dry-eyes-a-thermographic-approach
#6
Sara Matteoli, Eleonora Favuzza, Lucrezia Mazzantini, Pasquale Aragona, Stefania Cappelli, Andrea Corvi, Rita Mencucci
In recent decades infrared thermography (IR) has allowed accurate and quantitative measurements of the ocular surface temperature (OST), applying a non-invasive procedure. The objective of this work was to develop a procedure based on IR, which allows characterizing the cooling of the ocular surface of patients suffering from dry eye syndrome, and distinguishing among patients suffering from aqueous deficient dry eye (ADDE) and evaporative dry eyes (EDE). Approach: All patients examined (34F/4M, 23-84 years) were divided into two groups according to their Schirmer I result (≤7 mm for ADDE and >7 mm for EDE), and the OST was recorded for 7 s at 30Hz...
June 12, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28598549/the-presence-of-minocycline-in-the-tear-film-of-normal-horses-following-oral-administration-and-its-anticollagenase-activity
#7
Caroline S Monk, Sun Young Jeong, Daniel James Gibson, Caryn E Plummer
PURPOSE: Tetracyclines have activity against matrix metalloproteinases (MMP). Oral medications with effects on the ocular surface are of interest in patients where repeated topical dosing is limited. The aim of this study was to characterize the concentration of minocycline in the tears of normal horses after oral administration and to determine if this level directly inhibits MMP activity. METHODS: Five healthy adult ponies were administered oral minocycline (Wedgewood Pharmacy; Swedesboro, NJ) at 4 mg/kg every 12 h for 5 days...
June 9, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28593054/meibomian-gland-dysfunction-in-type-2-diabetic-patients
#8
Xiaolei Lin, Binbin Xu, Yuxi Zheng, Terry G Coursey, Yinying Zhao, Junhua Li, Yana Fu, Xuewen Chen, Yun-E Zhao
PURPOSE: To investigate meibomian gland and tear film function in patients with type 2 diabetes. METHODS: This prospective study compared changes in meibomian gland and tear film function in type 2 diabetic patients with nondiabetic patients. Meibomian gland function was evaluated by measuring lipid layer thickness (LLT), grading of meibomian gland loss, lid margin abnormalities, and expression of meibum. Tear film function was assessed by measuring tear breakup time (TBUT), the Schirmer I test, noninvasive breakup time (NIBUT), tear meniscus height (TMH), and corneal fluorescein staining...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28592257/clinical-safety-and-efficacy-of-vitamin-d3-analog-ointment-for-treatment-of-obstructive-meibomian-gland-dysfunction
#9
Reiko Arita, Motoko Kawashima, Masataka Ito, Kazuo Tsubota
BACKGROUND: Hyperkeratinization is a major cause of obstructive meibomian gland dysfunction (oMGD) and results in degenerative gland dilation and atrophy without inflammation. Ointment containing 1,25-dihydroxy-22-oxavitamin D3 (maxacalcitol), a noncalcemic analog of the active form of vitamin D3, is applied for the treatment of hyperkeratotic cutaneous conditions such as psoriasis and ichtyosis because it suppresses the proliferation and promotes the differentiation of keratinocytes through interaction with the vitamin D receptor...
June 7, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28587435/effect-of-topical-rebamipide-on-goblet-cells-in-the-lid-wiper-of-human-conjunctiva
#10
Satoru Kase, Toshiya Shinohara, Manabu Kase, Susumu Ishida
It has been demonstrated that topical administration of rebamipide, which is an antiulcer agent, increases the mucin level of the tear film and ameliorates ocular surface conditions such as lid wiper epitheliopathy. The aim of the present study was to analyze the changes in goblet cell number, cell proliferation, and epidermal growth factor receptor (EGFR) induced by topical rebamipide addition to the lid wiper of humans. A total of 30 eyelid tissue samples were obtained during involutional entropion surgeries, fixed in paraformaldehyde, embedded in paraffin and divided into two groups: Rebamipide or non-rebamipide...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28587370/a-novel-noninvasive-ocular-surface-analyzer-for-the-assessment-of-dry-eye-with-meibomian-gland-dysfunction
#11
Yuanyuan Qi, Chen Zhang, Shaozhen Zhao, Yue Huang, Ruibo Yang
Meibomian gland dysfunction (MGD) is a major cause of dry eye, and the purpose of the present study was to evaluate the differences between dry eye patients with MGD and controls using a novel noninvasive ocular surface analyzer. A total of 33 dry eye patients with MGD and 31 controls were enrolled in the present study. Testing included administration of the Ocular Surface Disease Index (OSDI), followed by Keratogragh 5M (Oculus, Wetzlar, Germany), measurements of the noninvasive tear film break-up times (NITBUTs), the first tear film break-up point and the morphology of meibomian gland...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28579744/randomized-comparison-of-in-vivo-performance-of-two-point-of-care-tear-film-osmometers
#12
Jerry Nolfi, Barbara Caffery
PURPOSE: To compare the in vivo precision of two commercially available point-of-care osmometers among normal subjects with no dry eye disease. METHODS: Twenty healthy adults with healthy ocular surfaces were evaluated by licensed eye care practitioners. All subjects had low Ocular Surface Disease Index score (<5), normal tear breakup time (>10 seconds), and no evidence of corneal fluorescein staining. Five consecutive measurements of tear osmolarity were measured on each eye using each of the two osmometers: the TearLab Osmolarity System (TearLab) and the I-Med i-Pen (i-Pen), for a total of 200 measurements per device...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28579061/classification-of-fluorescein-breakup-patterns-a-novel-method-of-differential-diagnosis-for-dry-eye
#13
Norihiko Yokoi, Georgi As Georgiev, Hiroaki Kato, Aoi Komuro, Yukiko Sonomura, Chie Sotozono, Kazuo Tsubota, Shigeru Kinoshita
PURPOSE: To investigate the relationship between fluorescein breakup patterns (FBUPs) and clinical manifestations in dry-eye cases. DESIGN: Cross-sectional study. METHODS: In 106 eyes of 106 subjects (19 males, 87 females; mean age: 64.2 years), FBUPs were categorized into 1 of the following 5 break (B) types: area (AB, n=19); spot (SB, n=22); line (LB, n=24); dimple (DB, n=19); random (RB, n=22 eyes), and dry-eye-related symptoms using the visual analog scale (VAS, 100mm=maximum), tear meniscus radius (TMR, mm), tear-film lipid-layer interference grade (IG) (grades 1-5; 1=best) and spread grade (SG) (grades 1-4; 1=best), tear-film non-invasive breakup time (NIBUT, seconds), FBU time (FBUT, seconds), corneal-epithelial damage (CED) score (15 points=maximum), ocular-surface epithelial damage (OSED) score (9 points=maximum), and the Schirmer 1 test (ST1, mm) were examined and compared between each FBUP...
June 1, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28576402/-anterior-lamellar-resection-with-lid-margin-split-of-the-upper-eyelid-in-the-treatment-of-trachomatous-entropion
#14
M Bouazza, M Elbelhadji, S Cherkaoui, A Mchachi, L Benhmidoune, A Chakib, R Rachid, A Amraoui
INTRODUCTION: The goal of this study is to assess functional and aesthetic results of anterior lamellar resection with lid margin splitting of the upper lid in the treatment of cicatricial trachomatous entropion. PATIENTS AND METHODS: Descriptive cross-sectional study of a series of 26 consecutive patients treated between January 2014 and December 2015. All patients were operated for cicatricial trachomatous entropion in our tertiary center using the technique of the anterior lamellar resection with lid margin splitting of the upper eyelid...
May 30, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28576215/effect-of-dry-eye-on-scheimpflug-imaging-of-the-cornea-and-elevation-data
#15
Leyla Asena, Dilek D Altınörs, Şefik Cezairlioğlu, Sefer Ogün Bölük
OBJECTIVE: To evaluate the effect of dry eye on Scheimpflug imaging of the cornea and elevation data. DESIGN: Prospective observational study. PARTICIPANTS: Scheimpflug images of 50 patients with dry eye who were being tested for eligibility for corneal refractive surgery were screened. Twelve eyes of 12 patients with abnormal Belin/Ambrosio enhanced ectasia display (BAD) anterior elevation difference were included in the study. The patients had no history of contact lens wear or any other sign of ectasia...
June 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28570988/photon-correlation-spectroscopy-applied-to-tear-analysis
#16
S Picarazzi, M Lecchi, V Pastori, M D'Arienzo, R Scotti, S Tavazzi
This study aims to deepen the knowledge on tear film properties by the development of a protocol for analyses of Photon Correlation Spectroscopy (PCS) on human tears and by the comparison between PCS results obtained on tears of contact lens wearers and non-wearers. Tears (5μL) were collected by a glass capillary. The analyses provide the hydrodynamic diameter of tear components by analyzing intensity fluctuations in time of scattered light. PCS appears a promising technique for studying tear features and for shedding light on specific eye conditions, such as on the clinical effects of CL wear...
May 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28557655/tear-film-stability-in-sj%C3%A3-gren-syndrome-patients-treated-with-hyaluronic-acid-versus-crosslinked-hyaluronic-acid-based-eye-drops
#17
Carlo Cagini, Giovanni Torroni, Tito Fiore, Alessio Cerquaglia, Marco Lupidi, Pasquale Aragona, Barbara Iaccheri
PURPOSE: To compare the stability of the tear film after instillation of eye drops containing hyaluronic acid (HA) or crosslinked hyaluronic acid (CLHA)-based in patients with Sjögren syndrome-related dry eye (SSDE). METHODS: Forty subjects were included in this study and were divided into 2 groups: the first group (control group) consisted of 20 healthy volunteers; the second group (study group) constituted of 20 suffering from SSDE; before and 5, 30, and 60 min after instillation of eye drops the surface regularity index (SRI) and surface asymmetry index (SAI) were registered...
May 30, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28553560/optical-coherence-tomography-reveals-changes-to-corneal-reflectivity-and-thickness-in-individuals-with-tear-hyperosmolarity
#18
Laura Adelaide Deinema, Algis Jonas Vingrys, Holly Rose Chinnery, Laura Elizabeth Downie
PURPOSE: To investigate whether tear hyperosmolarity, a feature of dry eye disease (DED), affects central corneal thickness (CCT), corneal light reflectivity, and/or tear film reflectivity. METHODS: This prospective, cross-sectional study involved 48 participants (38 with hyperosmolar tears and 10 controls with normo-osmolar tears). Symptoms and signs of DED (tear osmolarity, sodium fluorescein tear break-up time, ocular surface staining, Schirmer test) were assessed...
May 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28546925/comparison-of-corneal-biomechanics-in-sj%C3%A3-gren-s-syndrome-and-non-sj%C3%A3-gren-s-syndrome-dry-eyes-by-scheimpflug-based-device
#19
Qin Long, Jing-Yi Wang, Dong Xu, Ying Li
AIM: To compare the corneal biomechanics of Sjögren's syndrome (SS) and non-SS dry eyes with Corneal Visualization Scheimpflug Technology (CorVis ST). METHODS: Corneal biomechanics and tear film parameters, namely the Schirmer I test value, tear film break-up time (TBUT) and corneal staining score (CSS) were detected in 34 eyes of 34 dry eye patients with SS (SSDE group) and 34 dry eye subjects without SS (NSSDE group) using CorVis ST. The differences of the above parameters between the two groups were examined, and the relationship between corneal biomechanics and tear film parameters were observed...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28544605/assessment-of-meibomian-glands-and-tear-film-in-post-refractive-surgery-patients
#20
Ji Won Jung, Jung Yong Kim, Hee Seung Chin, Young Ju Suh, Tae-Im Kim, Kyoung Yul Seo
IMPORTANCE: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. BACKGROUND: To compare ocular surface parameters between post-refractive surgery patients and normal controls. DESIGN: Cross-sectional single center study PARTICIPANTS: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients...
May 22, 2017: Clinical & Experimental Ophthalmology
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