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https://www.readbyqxmd.com/read/29923556/regulating-the-golgi-apparatus-by-co-delivery-of-a-cox-2-inhibitor-and-brefeldin-a-for-suppression-of-tumor-metastasis
#1
Ru-Yi Yu, Lei Xing, Peng-Fei Cui, Jian-Bin Qiao, Yu-Jing He, Xin Chang, Tian-Jiao Zhou, Qing-Ri Jin, Hu-Lin Jiang, Yanyu Xiao
Finding a cure for breast cancer currently remains a medical challenge in due to the failure of common treatment methods to inhibit invasion and metastasis of cancer cells, which eventually leads to recurrence of breast cancer. Many secreted proteins are overexpressed and play crucial roles in tumorigenesis and development. The Golgi apparatus is a key protein processing and secretion factory in which metastasis-associated proteins are modified, transported and secreted; thus, regulating the Golgi apparatus of tumor cells is a viable strategy to inhibit tumor metastasis...
June 20, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29923153/black-tea-affects-obesity-by-reducing-nutrient-intake-and-activating-amp-activated-protein-kinase-in-mice
#2
Shunshun Pan, Xuming Deng, Shili Sun, Xingfei Lai, Lingli Sun, Qiuhua Li, Limin Xiang, Lingzhi Zhang, Yahui Huang
The effects of certain tea components on the prevention of obesity in humans have been reported recently. However, whether Yinghong NO. 9 black tea consumption has beneficial effects on obesity are not known. Here, we obtained a Yinghong NO. 9 black tea infusion (Y9 BTI) and examined the anti-obesity effects of its oral administration. ICR mice were fed a standard diet supplemented with Y9 BTI at 0.5, 1.0, or 2.0 g/kg body weight for two weeks, and the body weight were recorded. HE staining was used to evaluate the effect of Y9 BTI on mice liver...
June 19, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/29922878/aspirin-inspired-acetyl-donating-hdacs-inhibitors
#3
Jiah Lim, Yoojin Song, Jung-Hee Jang, Chul-Ho Jeong, Sooyeun Lee, Byoungduck Park, Young Ho Seo
Aspirin is one of the oldest drugs for the treatment of inflammation, fever, and pain. It is reported to covalently modify COX-2 enzyme by acetylating a serine amino acid residue. By virtue of aspirin's acetylating potential, we for the first time developed novel acetyl-donating HDAC inhibitors. In this study, we report the design, synthesis, in silico docking study, and biological evaluation of acetyl-donating HDAC inhibitors. The exposure of MDA-MB-231 cells with compound 4c significantly promotes the acetylation of α-tubulin and histone H3, which are substrates of HDAC6 and HDAC1, respectively...
June 20, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29922432/cyclooxygenase-inhibitors-combined-with-deuterium-enriched-water-augment-cytotoxicity-in-a549-lung-cancer-cell-line-via-activation-of-apoptosis-and-mapk-pathways
#4
Abdolreza Hassanzade, Ali Mandegary, Elham Sharif, Rokhsana Rasooli, Reza Mohammadnejad, Yaser Masoumi-Ardekani
Objectives: Combination chemotherapy is a rational strategy to increase patient response and tolerability and to decrease adverse effects and drug resistance. Recently, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been reported to be associated with reduction in occurrence of a variety of cancers including lung cancer. On the other hand, growing evidences suggest that deuterium-enriched water (DEW, D2O) and deuterium-depleted water (DDW) play a role both in treatment and prevention of cancers...
May 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29922158/-syzygium-aqueum-a-polyphenol-rich-leaf-extract-exhibits-antioxidant-hepatoprotective-pain-killing-and-anti-inflammatory-activities-in-animal-models
#5
Mansour Sobeh, Mona F Mahmoud, Ganna Petruk, Samar Rezq, Mohamed L Ashour, Fadia S Youssef, Assem M El-Shazly, Daria M Monti, Ashraf B Abdel-Naim, Michael Wink
Syzygium aqueum is widely used in folk medicine. A polyphenol-rich extract from its leaves demonstrated a plethora of substantial pharmacological properties. The extract showed solid antioxidant properties in vitro and protected human keratinocytes (HaCaT cells) against UVA damage. The extract also reduced the elevated levels of ALT, AST, total bilirubin (TB), total cholesterol (TC) and triglycerides (TG) in rats with acute CCl4 intoxication. In addition to reducing the high MDA level, the extract noticeably restored GSH and SOD to the normal control levels in liver tissue homogenates and counteracted the deleterious histopathologic changes in liver after CCl4 injection...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29922083/ferulic-acid-dimer-as-a-non-opioid-therapeutic-for-acute-pain
#6
Alaini Priebe, Megan Hunke, Raquel Tonello, Yogesh Sonawane, Temugin Berta, Amarnath Natarajan, Nattamai Bhuvanesh, Mahesh Pattabiraman, Surabhi Chandra
Purpose: Search for alternate pain medications has gained more importance in the past few years due to adverse effects associated with currently prescribed drugs including nervous system dysfunction with opioids, gastrointestinal discomfort with nonsteroidal anti-inflammatory drugs, and cardiovascular anomalies with cyclooxygenase-2 (COX-2) inhibitors. Phytomedicine has been explored for the treatment of pain, as these have been used for generations in regional communities and tend to lack major side effects in general...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29920917/lactobacillus-rhamnosus-gg-increases-cox-2-expression-and-pge-2-secretion-in-colonic-myofibroblasts-via-a-myd88-dependent-mechanism-during-homeostasis
#7
Gabriela Uribe, Romain Villéger, Philippe Bressollier, Rachel N Dillard, Daniel L Worthley, Timothy C Wang, Don W Powell, Maria C Urdaci, Irina V Pinchuk
Prostaglandin E2 (PGE2 ) plays a critical role in intestinal mucosal tolerance and barrier integrity. Cyclooxygenase-2 (COX-2)-dependent PGE2 production involves mobilization of arachidonic acid (AA). Lactobacillus rhamnosus GG (LbGG) is one of the most widely used probiotics reported to colonize the colonic mucosa. LbGG contributes to the protection of the small intestine against radiation injury through the repositioning of mucosal COX-2 expressing cells. However, it is unknown if LbGG modulates PGE2 production in the colonic mucosa under homeostasis and the major cellular elements involved in these processes...
June 19, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29920358/ephedra-gerardiana-aqueous-ethanolic-extract-and-fractions-attenuate-freund-complete-adjuvant-induced-arthritis-in-sprague-dawley-rats-by-downregulating-pge2-cox2-il-1%C3%AE-il-6-tnf-%C3%AE-nf-kb-and-upregulating-il-4-and-il-10
#8
Ambreen Malik Uttra, Alamgeer, Muhammad Shahzad, Arham Shabbir, Shah Jahan
ETHNOPHARMACOLOGICAL RELEVANCE: The whole plant, roots and stems of Ephedra gerardiana (Family Ephedraceae) have long been used as a folk remedy to treat rheumatism and painful joints in Northern Areas of Pakistan. AIM OF THE STUDY: The purpose of study was to observe the preventive efficacy of Ephedra gerardiana (EG) aerial parts in treating rheumatoid arthritis using Freund's complete adjuvant (FCA) induced arthritis in rat model and to determine its possible mechanism of action...
June 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913996/the-attenuation-of-pain-behaviour-and-serum-interleukin-6-concentration-by-nimesulide-in-a-rat-model-of-neuropathic-pain
#9
Taraneh Moini Zanjani, Masoumeh Sabetkasaei, Behnaz Karimian, Farzaneh Labibi, Babak Farokhi, Nariman Mossafa
Background Evidence for a role of immune system in hyperalgesic pain states is increasing. Recent work in neuroimmunology suggests that the immune system does more than simply perform its well known functions of recognizing and removing invading pathogens and tumors. Interest in neuroinflammation and neuroimmune activation has grown rapidly in recent years with the recognition of the role of central nervous system inflammatiom and immune responses in the aetiology of pain states. Among various theories, the role of inflammatory responses of the injured nerve has recently received attention...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913427/formononetin-inhibits-neuroinflammation-and-increases-estrogen-receptor-beta-er%C3%AE-protein-expression-in-bv2-microglia
#10
Abdelmeniem El-Bakoush, Olumayokun A Olajide
Formononetin is a bioactive non-steroidal polyphenol found in a variety of plants. In this study we evaluated the effects of formononetin on neuroinflammation in LPS-stimulated BV2 microglia. Results showed that formononetin significantly reduced the production of TNF-α, IL-6 and IL-1β, nitrite and PGE2 , as well as protein levels of iNOS and COX-2. Reporter gene assays showed that formononetin produced inhibition of NF-κB luciferase activity in HEK293 cells stimulated with TNF-α. Immunoblotting experiments revealed an inhibition of IKKα phosphorylation, with the resultant attenuation of phosphorylation and degradation of IκBα following LPS stimulation...
June 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29913095/inhibition-of-lps-induced-inflammatory-responses-by-satureja-hortensis-extracts-in-j774-1-macrophages
#11
Zahra Farzaneh, Kurosh Kalantar, Aida Iraji, Zahra Amirghofran
Macrophages are among the main cells involved in generation of inflammation. To investigate the anti-inflammatory effect of Satureja hortensis (summer savory), lipopolysaccharide (LPS)-activated J774.1 macrophages were treated with various extracts, and the expression and release of various inflammatory molecules by macrophages were examined. We showed that dichloromethane and hexane extracts reduced nitric oxide (NO) production more efficiently than other extracts. Both extracts decreased gene expression of inducible NO synthase (iNOS) (<0...
June 18, 2018: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29912150/in-vitro-anti-inflammatory-and-radical-scavenging-properties-of-chinotto-citrus-myrtifolia-raf-essential-oils
#12
Pierluigi Plastina, Astari Apriantini, Jocelijn Meijerink, Renger Witkamp, Bartolo Gabriele, Alessia Fazio
Chinotto ( Citrus myrtifolia Raf.) is a widely diffused plant native from China and its fruits have a wide-spread use in confectionary and drinks. Remarkably, only little has been reported thus far on its bioactive properties, in contrast to those of the taxonomically related bergamot ( Citrus bergamia Risso). The present study aimed to investigate potential in vitro anti-inflammatory and radical scavenging properties of chinotto essential oils (CEOs) and to establish to what extent their composition and bioactivities are dependent on maturation...
June 18, 2018: Nutrients
https://www.readbyqxmd.com/read/29911259/intercellular-communications-redox-interactions-in-radiation-toxicity-potential-targets-for-radiation-mitigation
#13
Bagher Farhood, Nasser Hashemi Goradel, Keywan Mortezaee, Neda Khanlarkhani, Ensieh Salehi, Maryam Shabani Nashtaei, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Hengameh Fallah, Masoud Najafi
Nowadays, using ionizing radiation (IR) is necessary for clinical, agricultural, nuclear energy or industrial applications. Accidental exposure to IR after a radiation terror or disaster poses a threat to human. In contrast to the old dogma of radiation toxicity, several experiments during the last two recent decades have revealed that intercellular signaling and communications play a key role in this procedure. Elevated level of cytokines and other intercellular signals increase oxidative damage and inflammatory responses via reduction/oxidation interactions (redox system)...
June 17, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29910615/preparation-characterizations-and-anti-pollutant-activity-of-7-3-4-trihydroxyisoflavone-nanoparticles-in-particulate-matter-induced-hacat-keratinocytes
#14
Pao-Hsien Huang, Chih-Hua Tseng, Chia-Yu Lin, Chiang-Wen Lee, Feng-Lin Yen
Background: 7,3',4'-Trihydroxyisoflavone (734THI), a secondary metabolite derived from daidzein in soybean, possesses several biological activities, including antioxidant, skin whitening and anti-atopic dermatitis properties, but the poor aqueous solubility of 734THI has limited its application in medicine and cosmetic industry. Methods: The aim of the present study was to improve the physicochemical properties of 734THI using planetary ball mill preparation under a solvent-free process to improve its solubility and anti-pollutant activity...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29907781/attenuation-of-inflammatory-responses-by-syringaresinol-via-map-kinase-mediated-suppression-of-nf-%C3%AE%C2%BAb-signaling-in-vitro-and-in-vivo
#15
Vivek K Bajpai, Md Badrul Alam, Khong Trong Quan, Mi-Kyoung Ju, Rajib Majumder, Shruti Shukla, Yun Suk Huh, MinKyun Na, Sang Han Lee, Young-Kyu Han
We examined the anti-inflammatory effects of (+)-syringaresinol (SGRS), a lignan isolated from Rubia philippinensis, in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells using enzyme-based immuno assay, Western blotting, and RT-PCR analyses. Additionally, in vivo effects of SGRS in the acute inflammatory state were examined by using the carrageenan-induced hind paw edema assay in experimental mice. As a result, treatment with SGRS (25, 50, and 100 μM) inhibited protein expression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and nuclear factor kappa B (NF-κB) as well as production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and interleukin-6 (IL-6) induced by LPS...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29906814/magnoflorine-enhances-lps-activated-pro-inflammatory-responses-via-myd88-dependent-pathways-in-u937-macrophages
#16
Md Areeful Haque, Ibrahim Jantan, Hemavathy Harikrishnan, Siti Mariam Abdul Wahab
Magnoflorine, a major bioactive metabolite isolated from Tinospora crispa, has been reported for its diverse biochemical and pharmacological properties. However, there is little report on its underlying mechanisms of action on immune responses, particularly on macrophage activation. In this study, we aimed to investigate the effects of magnoflorine, isolated from T. crispa on the pro-inflammatory mediators generation induced by LPS and the concomitant NF- κ B, MAPKs, and PI3K-Akt signaling pathways in U937 macrophages...
June 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29906688/in-vitro-and-in-vivo-studies-of-gold-i-azolate-phosphane-complexes-for-the-treatment-of-basal-like-breast-cancer
#17
Valentina Gambini, Martina Tilio, Eunice Wairimu Maina, Cristina Andreani, Caterina Bartolacci, Junbiao Wang, Manuela Iezzi, Stefano Ferraro, Anna Teresa Ramadori, Oumarou Camille Simon, Stefania Pucciarelli, Guojun Wu, Q Ping Dou, Cristina Marchini, Rossana Galassi, Augusto Amici
Basal like breast cancer (BLBC) is a very aggressive subtype of breast cancer giving few chances of survival, against which cisplatin based therapy is a compromise among the anticancer activity, the resistance development and the severe side effects. With the aim of finding new anticancer agents alternative to cisplatin, seven gold(I) azolate/phosphane compounds were evaluated in vitro by MTT tests in human MDA-MB-231, human mammary epithelial HMLE cells overexpressing FoxQ1, and murine A17 cells as models of BLBC...
June 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29906460/loss-of-virulence-in-nad-p-h-cytochrome-b5-oxidoreductase-deficient-leishmania-major
#18
Aditi Mukherjee, Ayan Adhikari, Priya Das, Saroj Biswas, Supratim Mukherjee, Subrata Adak
Leishmania promastigotes have the ability to synthesize essential polyunsaturated fatty acids de novo and can grow in lipid free media. Recently, we have shown that NAD(P)H cytochrome b5 oxidoreductase (Ncb5or) enzyme in Leishmania acts as the redox partner for Δ12 fatty acid desaturase, which catalyses the conversion of oleate to linoleate. So far, the exact role of Leishmania derived linoleate synthesis is still incomplete in the literature. The viability assay by flow cytometry as well as microscopic studies suggests that linoleate is an absolute requirement for Leishmania promastigote survival in delipidated media...
June 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29906224/high-salt-intake-shifts-the-mechanisms-of-flow-induced-dilation-in-the-middle-cerebral-arteries-of-sprague-dawley-rats
#19
Anita Matic, Ivana Jukic, Ana Stupin, Lidija Baric, Zrinka Mihaljevic, Sanela Unfirer, Ivana Tartaro Bujak, Branka Mihaljevic, Julian H Lombard, Ines Drenjancevic
The goal of this study was to examine the effect of 1-week of high salt (HS) intake and the role of oxidative stress in changing the mechanisms of flow-induced dilation (FID) in isolated pressurized middle cerebral arteries (MCA) of male Sprague-Dawley rats (N=15-16/per group). Reduced FID in the HS group was restored by intake of the superoxide scavenger TEMPOL (HS+TEMPOL in vivo group). Nitric oxide synthases (NOS) inhibitor Nω -nitro-L-arginine methyl ester (L-NAME), COX inhibitor indomethacin (INDO) and selective inhibitor of microsomal CYP450 epoxidase activity N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MS-PPOH) significantly reduced FID in the LS group, while FID in the HS group was mediated by NO only...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29904426/antinociceptive-effects-of-dezocine-on-complete-freund-s-adjuvant-induced-inflammatory-pain-in-rats
#20
Zhenhai Ye, Maoxian Zhang, Ning Ding, Peng Gao, Yunpeng Hei, Yun Wang, Wei Gao, Qingshan Ye
Inflammatory pain is known to severely impact the life quality of patients. Notably, dezocine is widely used for the treatment of pain. Therefore, the current study aimed to examine the effects of dezocine on a complete Freund's adjuvant (CFA)-induced inflammatory pain model in rats and to investigate the possible underlying molecular mechanisms. Rats were randomly divided into three groups, including the control, CFA and dezocine+CFA groups, and then subcutaneously injected with 100 µl saline, subcutaneously injected with 100 µl CFA or pretreated with 1 ml dezocine (0...
June 2018: Experimental and Therapeutic Medicine
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