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Gene-environment interaction alcohol

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https://www.readbyqxmd.com/read/29122391/genetics-and-epigenetics-of-nafld-and-nash-clinical-impact
#1
REVIEW
Mohammed Eslam, Luca Valenti, Stefano Romeo
Non-alcoholic fatty liver disease (NAFLD) is now recognised as the most common liver disease worldwide. It encompasses a broad spectrum of conditions, from simple steatosis, through non-alcoholic steatohepatitis, to fibrosis and ultimately cirrhosis and hepatocellular carcinoma. A hallmark of NAFLD is the substantial inter-patient variation in disease progression. NAFLD is considered a complex disease trait such that interactions between the environment and a susceptible polygenic host background determine disease phenotype and influence progression...
November 2, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29121402/incorporating-functional-genomic-information-to-enhance-polygenic-signal-and-identify-variants-involved-in-gene-by-environment-interaction-for-young-adult-alcohol-problems
#2
Jessica E Salvatore, Jeanne E Savage, Peter Barr, Aaron R Wolen, Fazil Aliev, Eero Vuoksimaa, Antti Latvala, Lea Pulkkinen, Richard J Rose, Jaakko Kaprio, Danielle M Dick
BACKGROUND: Characterizing aggregate genetic risk for alcohol misuse and identifying variants involved in gene-by-environment interaction (G×E) effects has so far been a major challenge. We hypothesized that functional genomic information could be used to enhance detection of polygenic signal underlying alcohol misuse, and to prioritize identification of single nucleotide polymorphisms (SNPs) most likely to exhibit G×E effects. METHODS: We examined these questions in the young adult FinnTwin12 sample (n=1170)...
November 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29069827/the-effect-of-mvk-mmab-variants-their-haplotypes-and-g%C3%A3-e-interactions-on-serum-lipid-levels-and-the-risk-of-coronary-heart-disease-and-ischemic-stroke
#3
Liu Miao, Rui-Xing Yin, Feng Huang, Wu-Xian Chen, Xiao-Li Cao, Jin-Zhen Wu
AIM: This study aimed to detect the association of the mevalonate kinase (MVK) and methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB) gene variants, their haplotypes, and gene-environment (G×E) interactions on serum lipid levels and the risk of coronary heart disease (CHD) and ischemic stroke (IS) in a Chinese Han population. METHODS: Genotyping of the rs3759387, rs7134594, rs877710 and rs9593 SNPs in 846 CHD and 869 IS patients and 847 healthy controls was performed by PCR-RFLP and Sanger sequencing...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28992386/interaction-between-the-%C3%AE-opioid-receptor-gene-and-the-number-of-heavy-drinking-peers-on-alcohol-use
#4
Michelle J Zaso, Stephen A Maisto, Stephen J Glatt, John M Belote, Aesoon Park
BACKGROUND: The presence of heavy-drinking peers may trigger genetic vulnerabilities to alcohol use. Limited correlational findings, albeit mixed as a function of age, suggest that carriers of a μ-opioid receptor (OPRM1) G allele may be more vulnerable than noncarriers to alcohol-promoting perceived peer environments. However, research has not yet examined such genetic susceptibility to actual (rather than perceived) peer environments through an experimental, ad libitum alcohol administration design...
October 9, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28987168/alcohol-related-diseases
#5
Serge Weis, Andreas Büttner
Alcohol abuse and dependence are serious medical and economic problems in Western countries. Brain changes encountered in alcoholism are manifold and encompass brain atrophy, selective neuronal loss, astroglial, and microglial changes. Alcohol-related disorders are complex multifactorial disorders where the interaction of multiple genes and environment plays an important role in the pathogenesis.
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28968965/association-between-single-nucleotide-polymorphisms-in-the-antioxidant-genes-cat-gr-and-sod1-erythrocyte-enzyme-activities-dietary-and-life-style-factors-and-breast-cancer-risk-in-a-danish-prospective-cohort-study
#6
Tine Iskov Kopp, Ulla Vogel, Lars Ove Dragsted, Anne Tjonneland, Gitte Ravn-Haren
Exposure to estrogens and alcohol consumption - the two only well-established risk factors for breast cancer - are capable of causing oxidative stress, which has been linked to progression of breast cancer. Here, five functional polymorphisms in the antioxidant genes SOD1, CAT and GSR were investigated in 703 breast cancer case-control pairs in the Danish, prospective "Diet, Cancer and Health" cohort together with gene-environment interactions between the polymorphisms, enzyme activities and intake of fruits and vegetables, alcohol and smoking in relation to breast cancer risk...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28956832/multiple-gene-environment-interactions-on-the-angiogenesis-gene-pathway-impact-rectal-cancer-risk-and-survival
#7
Noha Sharafeldin, Martha L Slattery, Qi Liu, Conrado Franco-Villalobos, Bette J Caan, John D Potter, Yutaka Yasui
Characterization of gene-environment interactions (GEIs) in cancer is limited. We aimed at identifying GEIs in rectal cancer focusing on a relevant biologic process involving the angiogenesis pathway and relevant environmental exposures: cigarette smoking, alcohol consumption, and animal protein intake. We analyzed data from 747 rectal cancer cases and 956 controls from the Diet, Activity and Lifestyle as a Risk Factor for Rectal Cancer study. We applied a 3-step analysis approach: first, we searched for interactions among single nucleotide polymorphisms on the pathway genes; second, we searched for interactions among the genes, both steps using Logic regression; third, we examined the GEIs significant at the 5% level using logistic regression for cancer risk and Cox proportional hazards models for survival...
September 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28938182/the-genetic-epidemiology-of-substance-use-disorder-a-review
#8
REVIEW
Elizabeth C Prom-Wormley, Jane Ebejer, Danielle M Dick, M Scott Bowers
BACKGROUND: Substance use disorder (SUD) remains a significant public health issue. A greater understanding of how genes and environment interact to regulate phenotypes comprising SUD will facilitate directed treatments and prevention. METHODS: The literature studying the neurobiological correlates of SUD with a focus on the genetic and environmental influences underlying these mechanisms was reviewed. Results from twin/family, human genetic association, gene-environment interaction, epigenetic literature, phenome-wide association studies are summarized for alcohol, nicotine, cannabinoids, cocaine, and opioids...
November 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28930051/addiction-and-the-role-of-circadian-genes
#9
Laura A Forde, Gursharan Kalsi
OBJECTIVE: In mammals, intimate interactions exist between the circadian system and other molecular systems, and mounting evidence is suggesting that these relationships may affect substance use disorders. Research in preclinical models supports the role of circadian genes as risk factors for addiction. Here, we explore the evidence and review human genetic studies testing the association between specific circadian genes and substance use disorders. METHOD: A literature search was conducted in PubMed for studies testing variants in eight circadian genes known to be central to the functioning of the master clock in the brain...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28921187/moderation-of-genetic-influences-on-alcohol-involvement-by-rural-residency-among-adolescents-results-from-the-1962-national-merit-twin-study
#10
Christal N Davis, Shanaliz S Natta, Wendy S Slutske
Adolescents in rural and urban areas may experience different levels of environmental restrictions on alcohol use, with those in rural areas experiencing greater monitoring and less access to alcohol. Such restrictions may limit expression of genetic vulnerability for alcohol use, resulting in a gene-environment interaction (G × E). This phenomenon has previously been reported in Finnish and Minnesota adolescents. The current study used data from 839 same-sex twin pairs from the 1962 National Merit Scholarship Qualifying Test to determine whether the G × E interaction would be evident in this earlier time period...
September 18, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28898263/genome-wide-analysis-of-parent-of-origin-interaction-effects-with-environmental-exposure-pooxe-an-application-to-european-and-asian-cleft-palate-trios
#11
Øystein A Haaland, Astanand Jugessur, Miriam Gjerdevik, Julia Romanowska, Min Shi, Terri H Beaty, Mary L Marazita, Jeffrey C Murray, Allen J Wilcox, Rolv T Lie, Håkon K Gjessing
Cleft palate only is a common birth defect with high heritability. Only a small fraction of this heritability is explained by the genetic variants identified so far, underscoring the need to investigate other disease mechanisms, such as gene-environment (GxE) interactions and parent-of-origin (PoO) effects. Furthermore, PoO effects may vary across exposure levels (PoOxE effects). Such variation is the focus of this study. We upgraded the R-package Haplin to enable direct tests of PoOxE effects at the genome-wide level...
2017: PloS One
https://www.readbyqxmd.com/read/28873402/gene-environment-interaction-study-for-bmi-reveals-interactions-between-genetic-factors-and-physical-activity-alcohol-consumption-and-socioeconomic-status
#12
Mathias Rask-Andersen, Torgny Karlsson, Weronica E Ek, Åsa Johansson
Previous genome-wide association studies (GWAS) have identified hundreds of genetic loci to be associated with body mass index (BMI) and risk of obesity. Genetic effects can differ between individuals depending on lifestyle or environmental factors due to gene-environment interactions. In this study, we examine gene-environment interactions in 362,496 unrelated participants with Caucasian ancestry from the UK Biobank resource. A total of 94 BMI-associated SNPs, selected from a previous GWAS on BMI, were used to construct weighted genetic scores for BMI (GSBMI)...
September 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28828224/social-and-environmental-enrichment-has-different-effects-on-ethanol-and-sucrose-consumption-in-mice
#13
Joan Y Holgate, Hilary Garcia, Susmita Chatterjee, Selena E Bartlett
BACKGROUND: Factors leading to the harmful consumption of substances, like alcohol and sucrose, involve a complex interaction of genes and the environment. While we cannot control the genes we inherit, we can modify our environment. Understanding the role that social and environmental experiences play in alcohol and sucrose consumption is critical for developing preventative interventions and treatments for alcohol use disorders and obesity. METHODS: We used the drinking in the dark two-bottle choice (2BC) model of ethanol and sucrose consumption to compare male C57BL/6 mice housed in the IntelliCage (an automated device capable of simultaneously measuring behaviors of up to 16 mice living in an enriched social environment) with mice housed in standard isolated and social environments...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28807841/racial-disparity-in-gastrointestinal-cancer-risk
#14
REVIEW
Hassan Ashktorab, Sonia S Kupfer, Hassan Brim, John M Carethers
Cancer from the gastrointestinal tract and its associated excretory organs will occur in more than 300,000 Americans in 2017, with colorectal cancer responsible for >40% of that burden; there will be more than 150,000 deaths from this group of cancers in the same time period. Disparities among subgroups related to the incidence and mortality of these cancers exist. The epidemiology and risk factors associated with each cancer bear out differences for racial groups in the United States. Esophageal adenocarcinoma is more frequent in non-Hispanic whites, whereas esophageal squamous cell carcinoma with risk factors of tobacco and alcohol is more frequent among blacks...
October 2017: Gastroenterology
https://www.readbyqxmd.com/read/28806535/interactions-between-genetic-polymorphisms-of-glucose-metabolizing-genes-and-smoking-and-alcohol-consumption-in-the-risk-of-type-2-diabetes-mellitus
#15
Kaiping Gao, Yongcheng Ren, Jinjin Wang, Zichen Liu, Jianna Li, Linlin Li, Bingyuan Wang, Hong Li, Yaxi Wang, Yunkai Cao, Kinji Ohno, Rihong Zhai, Zhen Liang
The impact of gene-environment interaction on diabetes remains largely unknown. We aimed to investigate if interaction between glucose metabolizing genes and lifestyle factors is associated with type 2 diabetes mellitus (T2DM). Interactions between genotypes of 4 glucose metabolizing genes (MTNR1B, KCNQ1, KLF14, and GCKR) and lifestyle factors were estimated in 722 T2DM patients and 759 controls, using multiple logistic regression. No significant associations with T2DM were detected for the single nucleotide polymorphisms of MTNR1B, KLF14 and GCKR...
August 14, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28761935/the-skin-microbiome-of-cohabiting-couples
#16
Ashley A Ross, Andrew C Doxey, Josh D Neufeld
Distinct microbial communities inhabit individuals as part of the human skin microbiome and are continually shed to the surrounding environment. Microbial communities from 17 skin sites of 10 sexually active cohabiting couples (20 individuals) were sampled to test whether cohabitation impacts an individual's skin microbiome, leading to shared skin microbiota among partner pairs. Amplified 16S rRNA genes of bacteria and archaea from a total of 340 skin swabs were analyzed by high-throughput sequencing, and the results demonstrated that cohabitation was significantly associated with microbial community composition, although this association was greatly exceeded by characteristics of body location and individuality...
July 2017: MSystems
https://www.readbyqxmd.com/read/28757931/new-insights-in-orofacial-cleft-epidemiological-and-genetic-studies-on-italian-samples
#17
L Tettamanti, A Avantaggiato, M Nardone, A Palmieri, A Tagliabue
Cleft of the lip and/or palate (CL±P) is the most common congenital craniofacial anomaly affecting around 1 in 700 live births worldwide. Clefts of the human face can be classified anatomically as cleft lip only (CL), cleft palate only (CP), cleft lip and palate (CLP) or a combined group of cleft lip with or without cleft palate (CL±P), based on differences in embryologic development. CL±P has a genetic base and several linkage and association analyses have been performed in order to obtain important information about the role of candidate genes in its onset; not less important are gene-environment interactions that play an increasing role in its aetiology...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28737466/association-of-adipoq-single-nucleotide-polymorphisms-and-smoking-interaction-with-the-risk-of-coronary-heart-disease-in-chinese-han-population
#18
Chen Liang, Xu Yawei, Wang Qinwan, Zhang Jingying, Mei Aihong, Chen Yanqing
AIMS: To investigate the impact of AdipoQ polymorphisms, and their additional interactions with smoking and drinking on coronary heart disease (CHD) risk based on Chinese population. METHODS: Hardy‒Weinberg equilibrium (HWE) was performed using SNPStats (available online at http://bioinfo.iconcologia.net/SNPstats ). Generalized multifactor dimensionality reduction (GMDR) model was used to screen the best gene‒gene and gene‒environment interaction combinations...
July 24, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28728635/gene-by-environment-interactions-on-alcohol-use-among-asian-american-college-freshmen
#19
Jeremy W Luk, Tiebing Liang, Tamara L Wall
OBJECTIVE: Among northeast Asians, the variant aldehyde dehydrogenase allele, ALDH2*2 (rs671, A/G, minor/major), has been inversely associated with alcohol dependence. The strength of the associations between ALDH2*2 and drinking behaviors depends on the developmental stage, the phenotype studied, and other moderating variables. This study examined ALDH2 gene status as a moderator of the associations between parental drinking, peer drinking, and acculturation with alcohol use among 222 Chinese American and Korean American college freshmen...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28728631/genes-environments-and-sex-differences-in-alcohol-research
#20
Jessica E Salvatore, Seung Bin Cho, Danielle M Dick
OBJECTIVE: The study of sex differences has been identified as one way to enhance scientific reproducibility, and the National Institutes of Health (NIH) have implemented a new policy to encourage the explicit examination of sex differences. Our goal here is to address sex differences in behavioral genetic research on alcohol outcomes. METHOD: We review sex differences for alcohol outcomes and whether the source and magnitude of genetic influences on alcohol consumption and alcohol use disorder (AUD) are the same across sexes; describe common research designs for studying sex-specific gene-by-environment interaction (G × E) effects; and discuss the role of statistical power and theory when testing sex-specific genetic effects...
July 2017: Journal of Studies on Alcohol and Drugs
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