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Gene-environment interaction alcohol

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https://www.readbyqxmd.com/read/28807841/racial-disparity-in-gastrointestinal-cancer-risk
#1
REVIEW
Hassan Ashktorab, Sonia S Kupfer, Hassan Brim, John M Carethers
Cancer from the gastrointestinal tract and its associated excretory organs will occur in over 300,000 Americans in 2017, with colorectal cancer responsible for over forty percent of that burden; there will be over 150,000 deaths from this group of cancers in the same time period. Disparities among subgroups related to these cancers' incidence and mortality exist. The epidemiology and risk factors associated with each cancer bear out differences for racial groups in the United States. Esophageal adenocarcinoma is more frequent in Non-Hispanic Whites, whereas esophageal squamous cell carcinoma with risk factors of tobacco and alcohol is more frequent among Blacks...
August 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28806535/interactions-between-genetic-polymorphisms-of-glucose-metabolizing-genes-and-smoking-and-alcohol-consumption-in-the-risk-of-type-2-diabetes-mellitus
#2
Kaiping Gao, Yongcheng Ren, Jinjin Wang, Zichen Liu, Jianna Li, Linlin Li, Bingyuan Wang, Hong Li, Yaxi Wang, Yunkai Cao, Kinji Ohno, Rihong Zhai, Zhen Liang
The impact of gene-environment interaction on diabetes remains largely unknown. We aimed to investigate whether interaction between glucose metabolizing genes and lifestyle factors are associated with type 2 diabetes mellitus (T2DM). METHODS- Interactions between genotypes of 4 glucose metabolizing genes (MTNR1B, KCNQ1, KLF14, and GCKR) and lifestyle factors were estimated in 722 T2DM patients and 759 controls, using multiple logistic regression. RESULTS- No significant associations with T2DM were detected for the SNPs of MTNR1B, KLF14 and GCKR...
August 14, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28761935/the-skin-microbiome-of-cohabiting-couples
#3
Ashley A Ross, Andrew C Doxey, Josh D Neufeld
Distinct microbial communities inhabit individuals as part of the human skin microbiome and are continually shed to the surrounding environment. Microbial communities from 17 skin sites of 10 sexually active cohabiting couples (20 individuals) were sampled to test whether cohabitation impacts an individual's skin microbiome, leading to shared skin microbiota among partner pairs. Amplified 16S rRNA genes of bacteria and archaea from a total of 340 skin swabs were analyzed by high-throughput sequencing, and the results demonstrated that cohabitation was significantly associated with microbial community composition, although this association was greatly exceeded by characteristics of body location and individuality...
July 2017: MSystems
https://www.readbyqxmd.com/read/28757931/new-insights-in-orofacial-cleft-epidemiological-and-genetic-studies-on-italian-samples
#4
L Tettamanti, A Avantaggiato, M Nardone, A Palmieri, A Tagliabue
Cleft of the lip and/or palate (CL±P) is the most common congenital craniofacial anomaly affecting around 1 in 700 live births worldwide. Clefts of the human face can be classified anatomically as cleft lip only (CL), cleft palate only (CP), cleft lip and palate (CLP) or a combined group of cleft lip with or without cleft palate (CL±P), based on differences in embryologic development. CL±P has a genetic base and several linkage and association analyses have been performed in order to obtain important information about the role of candidate genes in its onset; not less important are gene-environment interactions that play an increasing role in its aetiology...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28737466/association-of-adipoq-single-nucleotide-polymorphisms-and-smoking-interaction-with-the-risk-of-coronary-heart-disease-in-chinese-han-population
#5
Chen Liang, Xu Yawei, Wang Qinwan, Zhang Jingying, Mei Aihong, Chen Yanqing
AIMS: To investigate the impact of AdipoQ polymorphisms, and their additional interactions with smoking and drinking on coronary heart disease (CHD) risk based on Chinese population. METHODS: Hardy‒Weinberg equilibrium (HWE) was performed using SNPStats (available online at http://bioinfo.iconcologia.net/SNPstats ). Generalized multifactor dimensionality reduction (GMDR) model was used to screen the best gene‒gene and gene‒environment interaction combinations...
July 24, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28728635/gene-by-environment-interactions-on-alcohol-use-among-asian-american-college-freshmen
#6
Jeremy W Luk, Tiebing Liang, Tamara L Wall
OBJECTIVE: Among northeast Asians, the variant aldehyde dehydrogenase allele, ALDH2*2 (rs671, A/G, minor/major), has been inversely associated with alcohol dependence. The strength of the associations between ALDH2*2 and drinking behaviors depends on the developmental stage, the phenotype studied, and other moderating variables. This study examined ALDH2 gene status as a moderator of the associations between parental drinking, peer drinking, and acculturation with alcohol use among 222 Chinese American and Korean American college freshmen...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28728631/genes-environments-and-sex-differences-in-alcohol-research
#7
Jessica E Salvatore, Seung Bin Cho, Danielle M Dick
OBJECTIVE: The study of sex differences has been identified as one way to enhance scientific reproducibility, and the National Institutes of Health (NIH) have implemented a new policy to encourage the explicit examination of sex differences. Our goal here is to address sex differences in behavioral genetic research on alcohol outcomes. METHOD: We review sex differences for alcohol outcomes and whether the source and magnitude of genetic influences on alcohol consumption and alcohol use disorder (AUD) are the same across sexes; describe common research designs for studying sex-specific gene-by-environment interaction (G × E) effects; and discuss the role of statistical power and theory when testing sex-specific genetic effects...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28707126/estrogen-receptor-alpha-gene-esr1-polymorphism-and-its-interaction-with-smoking-and-drinking-contribute-to-susceptibility-of-systemic-lupus-erythematosus
#8
Aihong Zhou, Xin Liu, Tao Xia, Fang Li, Jibo Wang, Jun Li
The aim of this study is to investigate the association of estrogen receptor alpha gene (ESR1) polymorphisms, additional gene-gene, and gene-environment interaction with systemic lupus erythematosus (SLE) risk. SNPStats (available online at http://bioinfo.iconcologia.net/SNPstats ) was used to investigate the Hardy-Weinberg equilibrium (HWE) in controls and association between SNP and SLE risk. Generalized multifactor dimensionality reduction (GMDR) was used to screen the interactions among SNPs and environmental risk factors; SLE risk was significantly higher in carriers of rs2234693 C allele than those with TT (TC + CC versus TT), adjusted OR (95%CI) = 1...
August 2017: Immunologic Research
https://www.readbyqxmd.com/read/28670784/gene-environment-interactions-involving-functional-variants-results-from-the-breast-cancer-association-consortium
#9
Myrto Barrdahl, Anja Rudolph, John L Hopper, Melissa C Southey, Annegien Broeks, Peter A Fasching, Matthias W Beckmann, Manuela Gago-Dominguez, J Esteban Castelao, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Susan M Gapstur, Mia M Gaudet, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Ute Hamann, Arto Mannermaa, Diether Lambrechts, Lynn Jongen, Dieter Flesch-Janys, Kathrin Thoene, Fergus J Couch, Graham G Giles, Jacques Simard, Mark S Goldberg, Jonine Figueroa, Kyriaki Michailidou, Manjeet K Bolla, Joe Dennis, Qin Wang, Ursula Eilber, Sabine Behrens, Kamila Czene, Per Hall, Angela Cox, Simon Cross, Anthony Swerdlow, Minouk J Schoemaker, Alison M Dunning, Rudolf Kaaks, Paul D P Pharoah, Marjanka Schmidt, Montserrat Garcia-Closas, Douglas F Easton, Roger L Milne, Jenny Chang-Claude
Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene-environment interactions. We assessed the interplay between 70 SNPs identified by genetic fine-scale mapping of susceptibility loci and 11 epidemiological breast cancer risk factors in relation to breast cancer. Analyses were conducted on up to 58,573 subjects (26,968 cases, 31,605 controls) from the Breast Cancer Association Consortium (BCAC), in one of the largest studies of its kind. Analyses were carried out separately for estrogen receptor positive (ER+) and estrogen receptor negative (ER-) disease...
July 3, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28652424/the-contribution-of-matrix-metalloproteinase-8-promoter-polymorphism-to-oral-cancer-susceptibility
#10
Yi-Wen Hung, Chia-Wen Tsai, Cheng-Nan Wu, Liang-Chun Shih, Yen-Yu Chen, Yen-Fang Liu, Huey-Shan Hung, Ming-Yi Shen, Wen-Shin Chang, DA-Tian Bau
BACKGROUND/AIM: Metalloproteinases (MMPs) are a family of multifunctional proteins reported to be overexpressed in several types of cancers. However, the contribution of MMP8 genotype to oral cancer has not been elucidated. In this study, we focused on the contribution of polymorphisms in the promoter region of MMP-8 (C-799T) and two non-synonymous polymorphisms (Val436Ala and Lys460Thr) to Taiwanese oral cancer. MATERIALS AND METHODS: In this case-control study, MMP-8 genotype, was examined among 788 patients with oral cancer and 956 gender- and age-matched healthy controls regarding its potential to determine oral cancer risk...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28627812/genetics-of-alcohol-consumption-in-drosophila-melanogaster
#11
Sophia Fochler, Tatiana V Morozova, Morgan R Davis, Alexander W Gearhart, Wen Huang, Trudy F C Mackay, Robert R H Anholt
Individual variation in alcohol consumption in human populations is determined by genetic, environmental, social and cultural factors. In contrast to humans, genetic contributions to complex behavioral phenotypes can be readily dissected in Drosophila, where both the genetic background and environment can be controlled and behaviors quantified through simple high-throughput assays. Here, we measured voluntary consumption of ethanol in ~3,000 individuals of each sex from an advanced intercross population derived from 37 lines of the Drosophila melanogaster Genetic Reference Panel...
June 19, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28622698/interactions-between-acyp2-genetic-polymorphisms-and-environment-factors-with-susceptibility-to-ischemic-stroke-in-a-han-chinese-population
#12
Qiong Cheng, Yong-Kun Li, Feng Lu, Lianhua Yin, Yin-Zhou Wang, Wen Wei, Qian Lin
AIMS: To investigate the association of several single nucleotide polymorphisms (SNPs) within ACYP2 gene and additional gene- environment interaction with ischemic stroke (IS) risk in a Chinese population. RESULTS: IS risk was significantly higher in carriers with the G allele of rs11896604 than those with CC genotype (CG or GG versus CC), adjusted OR (95%CI) =1.60 (1.18-2.20), and higher in carriers with the A allele of rs12615793 than those with GG genotype (GA or AA versus GG), adjusted OR (95%CI) = 1...
June 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28620071/multiancestry-study-of-gene-lifestyle-interactions-for-cardiovascular-traits-in-610-475-individuals-from-124-cohorts-design-and-rationale
#13
D C Rao, Yun J Sung, Thomas W Winkler, Karen Schwander, Ingrid Borecki, L Adrienne Cupples, W James Gauderman, Kenneth Rice, Patricia B Munroe, Bruce M Psaty
BACKGROUND: Several consortia have pursued genome-wide association studies for identifying novel genetic loci for blood pressure, lipids, hypertension, etc. They demonstrated the power of collaborative research through meta-analysis of study-specific results. METHODS AND RESULTS: The Gene-Lifestyle Interactions Working Group was formed to facilitate the first large, concerted, multiancestry study to systematically evaluate gene-lifestyle interactions. In stage 1, genome-wide interaction analysis is performed in 53 cohorts with a total of 149 684 individuals from multiple ancestries...
June 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28599285/association-between-single-nucleotide-polymorphisms-in-the-antioxidant-genes-cat-gr-and-sod1-erythrocyte-enzyme-activities-dietary-and-life-style-factors-and-breast-cancer-risk-in-a-danish-prospective-cohort-study
#14
Tine Iskov Kopp, Ulla Vogel, Lars Ove Dragsted, Anne Tjonneland, Gitte Ravn-Haren
Exposure to estrogens and alcohol consumption - the two only well-established risk factors for breast cancer - are capable of causing oxidative stress, which has been linked to progression of breast cancer. Here, five functional polymorphisms in the antioxidant genes SOD1, CAT and GSR were investigated in 703 breast cancer case-control pairs in the Danish, prospective "Diet, Cancer and Health" cohort together with gene-environment interactions between the polymorphisms, enzyme activities and intake of fruits and vegetables, alcohol and smoking in relation to breast cancer risk...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28560381/hypomethylation-of-the-toll-like-receptor-2-gene-increases-the-risk-of-essential-hypertension
#15
Shuqi Mao, Tianlun Gu, Fade Zhong, Rui Fan, Fubao Zhu, Peipei Ren, Fengying Yin, Lina Zhang
Studies on the etiology of essential hypertension (EH) have demonstrated that chronic inflammation contributes to the onset and development of elevated blood pressure. Toll‑like receptors (TLRs), important immune receptors, serve a role in chronic inflammation and are associated with EH. In the present study, 96 patients with EH, and 96 age‑ and sex‑matched healthy controls were recruited, and eight cytosine‑phosphate‑guanine (CpG) dinucleotides (CpG1‑8) were analyzed using bisulfite pyrosequencing technology...
July 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28494133/interaction-between-adh1b-3-and-alcohol-facilitating-social-environments-in-alcohol-behaviors-among-college-students-of-african-descent
#16
Jessica M Desalu, Michelle J Zaso, Jueun Kim, John M Belote, Aesoon Park
BACKGROUND AND OBJECTIVES: Although alcohol-facilitating social environmental factors, such as alcohol offers and high perceived peer drinking norms, have been extensively studied as determinants of college drinking, their role among college students of African descent remains understudied. Furthermore, gene-environment interaction research suggests that the effects of alcohol-facilitating environments may differ as a function of genetic factors. Specifically, the alcohol dehydrogenase gene's ADH1B*3 allele, found almost exclusively in persons of African descent, may modulate the association of risky social environments with alcohol behaviors...
June 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28470828/neurological-and-neuropsychological-effects-of-low-and-moderate-prenatal-alcohol-exposure
#17
REVIEW
E Comasco, J Rangmar, U J Eriksson, L Oreland
Several explanations for the diverse results in research on foetal alcohol spectrum disorders or alcohol-related neurodevelopmental disorder might be at hand: timing, amount and patterns of alcohol exposure, as well as complex epigenetic responses. The genetic background of the offspring and its interaction with other prenatal and post-natal environmental cues are likely also of importance. In the present report, key findings about the possible effects of low and moderate doses of maternal alcohol intake on the neuropsychological development of the offspring are reviewed and plausible mechanisms discussed...
May 4, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28441416/ethanol-itself-is-a-holoprosencephaly-inducing-teratogen
#18
Mingi Hong, Robert S Krauss
Ethanol is a teratogen, inducing a variety of structural defects in developing humans and animals that are exposed in utero. Mechanisms of ethanol teratogenicity in specific defects are not well understood. Oxidative metabolism of ethanol by alcohol dehydrogenase or cytochrome P450 2E1 has been implicated in some of ethanol's teratogenic effects, either via production of acetaldehyde or competitive inhibition of retinoic acid synthesis. Generalized oxidative stress in response to ethanol may also play a role in its teratogenicity...
2017: PloS One
https://www.readbyqxmd.com/read/28431792/changes-to-histone-modifications-following-prenatal-alcohol-exposure-an-emerging-picture
#19
REVIEW
Eric J Chater-Diehl, Benjamin I Laufer, Shiva M Singh
Epigenetic mechanisms are important for facilitating gene-environment interactions in many disease etiologies, including Fetal Alcohol Spectrum Disorders (FASD). Extensive research into the role of DNA methylation and miRNAs in animal models has illuminated the complex role of these mechanisms in FASD. In contrast, histone modifications have not been as well researched, due in part to being less stable than DNA methylation and less well-characterized in disease. It is now apparent that even changes in transient marks can have profound effects if they alter developmental trajectories...
May 2017: Alcohol
https://www.readbyqxmd.com/read/28427149/interaction-between-ppar-%C3%AE-and-sorl1-gene-with-late-onset-alzheimer-s-disease-in-chinese-han-population
#20
Hui Zhang, Wei Zheng, Linlin Hua, Yutong Wang, Jinfeng Li, Hongying Bai, Shanshan Wang, Mingyao Du, Xuelian Ma, Chunyang Xu, Xiaodong Li, Bin Gong, Yunliang Wang
AIMS: To investigate the impact of sortilin-related receptor 1 gene 1 (SORL1) and peroxisome proliferator activated receptor gamma (PPAR G) gene single nucleotide polymorphisms (SNPs), gene- gene and gene- environment interactions and haplotype on late-onset Alzheimer's disease (LOAD) risk. METHODS: Hardy-Weinberg equilibrium (HWE), haplotype analysis and pairwise linkage disequilibrium (LD) analysis were investigated by using SNPStats (available online at http://bioinfo...
July 18, 2017: Oncotarget
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