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https://www.readbyqxmd.com/read/28403188/molecular-pathways-associated-with-blood-pressure-and-hexadecanedioate-levels
#1
Cristina Menni, Sarah J Metrustry, Georg Ehret, Anna F Dominiczak, Phil Chowienczyk, Tim D Spector, Sandosh Padmanabhan, Ana M Valdes
The dicarboxylic acid hexadecanedioate is associated with increased blood pressure (BP) and mortality in humans and feeding it to rats raises BP. Here we aim to characterise the molecular pathways that influence levels of hexadecanedioate linked to BP regulation, using genetic and transcriptomic studies. The top associations for hexadecanedioate in a genome-wide association scan (GWAS) conducted on 6447 individuals from the TwinsUK and KORA cohorts were tested for association with BP and hypertension in the International Consortium for BP and in a GWAS of BP extremes...
2017: PloS One
https://www.readbyqxmd.com/read/28361821/candidate-genes-for-alcohol-dependence-a-genetic-association-study-from-india
#2
Savita Malhotra, Debasish Basu, Madhu Khullar, Abhishek Ghosh, Neera Chugh
BACKGROUND & OBJECTIVES: Search for candidate genes for alcohol dependence (AD) has been inconsistent and inconclusive. Moreover, most of the research has been confined to a few specific ethnic groups. Hence, the aim of our study was to explore specific candidate genes for AD in north Indian male population. METHODS: In this clinic-based genetic association study, 210 males with AD and 200 controls matched for age, gender and ethnicity were recruited from the clinic and the general population, respectively...
November 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28349588/adh1b-from-alcoholism-natural-selection-and-cancer-to-the-human-phenome
#3
REVIEW
Renato Polimanti, Joel Gelernter
The ADH1B (Alcohol Dehydrogenase 1B (class I), Beta Polypeptide) gene and its best-known functional alleles, Arg48His (rs1229984, ADH1B*2) and Arg370Cys (rs2066702, ADH1B*3), have been investigated in relation to many phenotypic traits; most frequently including alcohol metabolism and alcohol drinking behaviors, but also human evolution, liver function, cancer, and, recently, the comprehensive human phenome. To understand ADH1B functions and consequences, we provide here a bioinformatic analysis of its gene regulation and molecular functions, literature review of studies focused on this gene, and a discussion regarding future research perspectives...
March 27, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28295416/validating-harmful-alcohol-use-as-a-phenotype-for-genetic-discovery-using-phosphatidylethanol-and-a-polymorphism-in-adh1b
#4
Amy C Justice, Kathleen A McGinnis, Janet P Tate, Ke Xu, William C Becker, Hongyu Zhao, Joel Gelernter, Henry R Kranzler
BACKGROUND: Although alcohol risk is heritable, few genetic risk variants have been identified. Longitudinal electronic health record (EHR) data offer a largely untapped source of phenotypic information for genetic studies, but EHR-derived phenotypes for harmful alcohol exposure have yet to be validated. Using a variant of known effect, we used EHR data to develop and validate a phenotype for harmful alcohol exposure that can be used to identify unknown genetic variants in large samples...
March 11, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28236470/effect-of-alcohol-and-its-metabolites-in-lung-cancer-capua-study
#5
Sara M Álvarez-Avellón, Ana Fernández-Somoano, Eva M Navarrete-Muñoz, Jesús Vioque, Adonina Tardón
BACKGROUND AND OBJECTIVE: Alcohol and its metabolites play an important role in carcinogenesis. This effect could be modulated by polymorphisms in genes encoding enzymes involved in the metabolism of alcohol and folate. Therefore, we analyzed the effect of alcohol consumption and ADH1B Arg48His, ADH1B Arg370Cys, ADH1C Ile349Val, ALDH2 Glu540Lys, CYP2E1 RsaI, CYP2E1 DraI, CYP2E1 TaqI and MTHFR C677T polymorphisms on the risk of developing lung cancer. PATIENTS AND METHODS: We included 876 lung cancer cases and 840 controls of the CAPUA hospital-based case-control study...
February 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28212614/transcriptomic-profiling-provides-molecular-insights-into-hydrogen-peroxide-induced-adventitious-rooting-in-mung-bean-seedlings
#6
Shi-Weng Li, Yan Leng, Rui-Fang Shi
BACKGROUND: Hydrogen peroxide (H2O2) has been known to function as a signalling molecule involved in the modulation of various physiological processes in plants. H2O2 has been shown to act as a promoter during adventitious root formation in hypocotyl cuttings. In this study, RNA-Seq was performed to reveal the molecular mechanisms underlying H2O2-induced adventitious rooting. RESULTS: RNA-Seq data revealed that H2O2 treatment greatly increased the numbers of clean reads and expressed genes and abundance of gene expression relative to the water treatment...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212515/combination-of-aldh2-and-adh1b-polymorphisms-is-associated-with-smoking-initiation-a-large-scale-cross-sectional-study-in-a-japanese-population
#7
Hiroyuki Masaoka, Hidemi Ito, Silvano Gallus, Miki Watanabe, Akira Yokomizo, Masatoshi Eto, Keitaro Matsuo
BACKGROUND: Aldehyde dehydrogenase 2 (ALDH2; rs671, Glu504Lys) and alcohol dehydrogenase 1B (ADH1B; rs1229984, His47Arg) polymorphisms are known to strongly influence alcohol drinking behavior. Given evidence of an association between smoking and drinking behaviors, we hypothesized that ALDH2/ADH1B polymorphisms might also be associated with smoking initiation, and conducted a cross-sectional study to examine this hypothesis. METHODS: Study subjects were first-visit outpatients diagnosed not to have cancer at Aichi Cancer Center Hospital between 2001 and 2005, including 4141 never smokers and 2912 ever smokers...
April 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28182702/natural-formulas-and-the-nature-of-formulas-exploring-potential-therapeutic-targets-based-on-traditional-chinese-herbal-formulas
#8
Qianru Zhang, Hua Yu, Jin Qi, Daisheng Tang, Xiaojia Chen, Jian-Bo Wan, Peng Li, Hao Hu, Yi-Tao Wang, Yuanjia Hu
By comparing the target proteins (TPs) of classic traditional Chinese medicine (TCM) herbal formulas and modern drugs used for treating coronary artery disease (CAD), this study aimed to identify potential therapeutic TPs for treating CAD. Based on the theory of TCM, the Xuefu-Zhuyu decoction (XZD) and Gualou-Xiebai-Banxia decoction (GXBD), both of which are classic herbal formulas, were selected for treating CAD. Data on the chemical ingredients and corresponding TPs of the herbs in these two formulas and data on modern drugs approved for treating CAD and related TPs were retrieved from professional TCM and bioinformatics databases...
2017: PloS One
https://www.readbyqxmd.com/read/28098394/use-of-asian-samples-in-genetic-research-of-alcohol-use-disorders-genetic-variation-of-alcohol-metabolizing-enzymes-and-the-effects-of-acetaldehyde
#9
Sachio Matsushita, Susumu Higuchi
BACKGROUND AND OBJECTIVES: Epidemiological studies consistently find that Asian populations report lower rates of alcohol use disorders (AUD) compared with other racial groups. These differences result from a variety of biological, genetic, and environmental influences, some of which are related to the metabolism of alcohol. We will review several studies of these metabolic factors, including several alcohol clamping studies conducted in our laboratory, that provide further insight into the role of the alcohol metabolizing genes and drinking behavior among Japanese drinkers...
January 18, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28002588/analysis-of-adh1b-arg47his-aldh2-glu487lys-and-cyp4502e1-polymorphisms-in-gastric-cancer-risk-and-interaction-with-environmental-factors
#10
Z H Chen, J F Xian, L P Luo
Gastric cancer is the fourth commonly diagnosed cancer and the second most frequent cause of cancer death worldwide. Genetic variations in ADH1B and ALDH2 may alter the function and activity of the corresponding enzymes, leading to differences in acetaldehyde exposure between drinkers. Cytochrome P4502E1 (CYP4502E1) is a phase I enzyme that plays an important role in metabolizing nitrosamine compounds and the bioactivation of procarcinogens. During the period of July 2013 to July 2015, 246 patients and 274 controls were enrolled from the First Affiliated Hospital of Jinan University...
December 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27991683/platelet-counts-and-genetic-polymorphisms-of-alcohol-dehydrogenase-1b-and-aldehyde-dehydrogenase-2-in-japanese-alcoholic-men
#11
Akira Yokoyama, Tetsuji Yokoyama, Takeshi Mizukami, Toshifumi Matsui, Mitsuru Kimura, Sachio Matsushita, Susumu Higuchi, Katsuya Maruyama
BACKGROUND: Thrombocytopenia during intoxication, rebound thrombocytosis during 1 to 3 weeks of abstinence, and subsequent normalization of the platelet count are common in alcoholics. METHODS: We evaluated 989 Japanese alcoholic men to identify the effects of genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984) and aldehyde dehydrogenase-2 (ALDH2; rs671) on platelet counts during an 8-week in-hospital abstinence period. RESULTS: Thrombocytopenia (<15 × 10(4) /μl) was observed in 25...
January 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27986911/aldehyde-dehydrogenase-2-polymorphism-is-a-predictor-of-smoking-cessation
#12
Hiroyuki Masaoka, Silvano Gallus, Hidemi Ito, Miki Watanabe, Akira Yokomizo, Masatoshi Eto, Keitaro Matsuo
INTRODUCTION: Smoking cessation has been known to be associated with drinking behaviors, which are influenced by polymorphisms in genes encoding alcohol metabolizing enzymes. The aim was to evaluate the impact of aldehyde dehydrogenase 2 (ALDH2, rs671) and alcohol dehydrogenase 1B (ADH1B, rs1229984) polymorphisms together with drinking behaviors on smoking cessation. METHODS: We conducted a cross-sectional study with 1137 former smokers and 1775 current smokers without any cancer at Aichi Cancer Center Hospital between 2001 and 2005...
December 16, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27941269/duplex-pcr-rflp-for-the-simultaneous-genotyping-of-single-nucleotide-polymorphisms-in-adh1b-and-aldh2-genes
#13
Naoto Shirasu, Shin'ichiro Yasunaga
Single nucleotide polymorphisms (SNPs) in ADH1B and ALDH2, which encode alcohol dehydrogenase 1B and aldehyde dehydrogenase 2, respectively, are responsible for ethanol-metabolizing activity and alcohol-related disease. We developed a simple and rapid polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) method for the simultaneous genotyping of the genes in a single-tube reaction. Using an alkaline lysate of a human hair root as a template, SNP-containing regions of each gene were PCR-amplified simultaneously...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27927211/genetic-variations-of-aldehyde-dehydrogenase-2-and-alcohol-dehydrogenase-1b-are-associated-with-the-etiology-of-atrial-fibrillation-in-japanese
#14
Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Naoya Hironomobe, Chikaaki Motoda, Nozomu Oda, Kazuaki Chayama, Che-Hong Chen, Eric R Gross, Daria Mochly-Rosen, Yasuki Kihara
BACKGROUND: Alcohol consumption and oxidative stress are well-known risk factors for developing atrial fibrillation (AF). Single nucleotide polymorphisms (SNPs) of alcohol dehydrogenase (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes encoding enzymes of alcohol and reactive aldehyde metabolism, respectively, are prevalent among East Asians. Here, we examined whether these SNPs were associated with AF in Japanese patients. METHODS AND RESULTS: Five hundred seventy-seven Japanese patients with AF undergoing catheter ablation and 1935 controls at Hiroshima University Hospital were studied...
December 7, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27808372/role-of-adh1b-rs1229984-and-aldh2-rs671-gene-polymorphisms-in-the-development-of-alzheimer-s-disease
#15
L Ma, Z N Lu
In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer's disease (OR = 2.54, 95%CI = 1.19-5.41). In addition, ADH1B rs1229984 was also associated with elevated risk of Alzheimer's disease in both dominant (OR = 1...
October 5, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27801545/the-allele-frequency-of-aldh2-glu504lys-and-adh1b-arg47his-for-the-ryukyu-islanders-and-their-history-of-expansion-among-east-asians
#16
Kae Koganebuchi, Kuniaki Haneji, Takashi Toma, Keiichiro Joh, Hidenobu Soejima, Kazuma Fujimoto, Hajime Ishida, Motoyuki Ogawa, Tsunehiko Hanihara, Shoji Harada, Shoji Kawamura, Hiroki Oota
OBJECTIVES: A cline of frequencies of the derived allele of the ALDH2 gene, which causes a deficiency of an enzyme and "facial flushing" in humans who drink alcohol, has been known among the people of the Japanese archipelago. This cline is conventionally explained by admixture with immigrants from the Asian continent occurring during the Yayoi period. Previous studies lack sufficient data from the peripheral regions of the indigenous Jomon people, and those data the ADH1B gene that is involved in the Class I ADH gene cluster and contains another variant leading to a functional change...
November 1, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27784874/the-effect-of-consuming-small-volumes-of-beer-on-gastric-motility-and-the-involvement-of-gene-polymorphisms
#17
Tomoyuki Shibata, Hiromi Yamashita, Tomohiko Kawamura, Yasutaka Jodai, Takafumi Omori, Kazuya Sumi, Yuichiro Ichikawa, Masaaki Okubo, Takamitsu Ishizuka, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshihito Nakagawa, Ichiro Hirata, Naoki Ohmiya, Makoto Nakao
The aim of this study was to investigate the effect of consuming small amounts of beer or a nonalcoholic beer taste beverage (non-beer) on gastric emptying and the polymorphisms in alcohol metabolism-related enzyme-encoding genes. Twenty male healthy volunteers were questioned regarding their alcohol consumption status, and body measurement was performed. The genetic polymorphisms in ADH1B (rs1229984, Arg47His) and ALDH2 (rs671 Glu487Lys) were analyzed. The subjects consumed 150 mL of beer or non-beer once per week, followed by the ingestion of 200 kcal of the test nutrient containing (13)C-acetate 15 min later, after which the subjects' exhalations were collected up to 120 min...
2016: Biomedical Research
https://www.readbyqxmd.com/read/27778410/mendelian-randomisation-suggests-no-beneficial-effect-of-moderate-alcohol-consumption-on-the-severity-of-nonalcoholic-fatty-liver-disease
#18
S Sookoian, D Flichman, G O Castaño, C J Pirola
BACKGROUND: Previous epidemiological studies suggest that patients diagnosed with nonalcoholic fatty liver disease (NAFLD) who drink light to moderate amounts of alcohol (up to ~30 g per day) have less severe histological lesions compared with nondrinkers. However, while the cross-sectional nature of current evidence precludes assessment of causality, cumulative lifetime-exposure of moderate alcohol consumption on histological outcomes has never been evaluated. AIM: To overcome these limitations, a Mendelian randomisation study was performed using a validated genetic variant (rs1229984 A;G) in the alcohol dehydrogenase (ADH1B) gene as a proxy of long-term alcohol exposure...
December 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27706775/association-of-adh1b-arg47his-and-aldh2-glu487lys-polymorphisms-with-risk-of-colorectal-cancer-and-their-interaction-with-environmental-factors-in-a-chinese-population
#19
Q Zhong, R R Wu, Z M Zeng
Human colorectal cancer (CRC) is a major worldwide health concern, and its development has been shown to be associated with alcohol intake. We carried out a study to investigate the effect of the ADH1B Arg47His and ALDH2 Glu487Lys genetic polymorphisms and their interaction with alcohol consumption on development of CRC. Between March 2013 and May 2015, a total of 274 CRC patients and 358 healthy controls were recruited. Genotyping of sequence variations was performed using the polymerase chain reaction-restriction fragment length polymorphism method...
September 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27689323/adh1b-and-cdh1-polymorphisms-predict-prognosis-in-male-patients-with-non-metastatic-laryngeal-cancer
#20
Daxu Li, Ruizhi Zhang, Tianbo Jin, Na He, Le Ren, Zhe Zhang, Qingna Zhang, Ran Xu, Hong Tao, Guang Zeng, Jing Gao
In this study, we assessed the association between single nucleotide polymorphisms (SNPs) in candidate genes and the prognosis of laryngeal cancer (LC) patients. Thirty-seven SNPs in 26 genes were genotyped in 170 male Han Chinese patients with LC. The effects of the candidate genes on the prognosis of LC patients were evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. The GA genotype of rs1229984 (hazard ratio [HR], 0.537; 95% confidence interval [CI], 0.340-0.848; p = 0.008) in alcohol dehydrogenase 1B (ADH1B), and the AA genotype of rs9929218 (HR, 6...
November 8, 2016: Oncotarget
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