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ADH1B

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https://www.readbyqxmd.com/read/28731573/effect-of-alcohol-dehydrogenase-1b-and-7-polymorphisms-on-blood-ethanol-and-acetaldehyde-concentrations-in-healthy-subjects-with-a-history-of-moderate-alcohol-consumption
#1
Roberta Pastorino, Luigi Iuliano, Alessia Vecchioni, Dario Arzani, Mirta Milic, Francesca Annunziata, Chiara Zerbinati, Ettore Capoluongo, Stefano Bonassi, James D McKay, Stefania Boccia
AIMS: To evaluate the effect of ADH1B and ADH7 genotypes on blood acetaldehyde and ethanol levels after alcohol ingestion, and to measure the genotoxic effect of smoking and ethanol on the buccal cells, also controlling for ADH variants. METHODS: We recruited healthy Italian subjects with at least a moderate history of alcohol consumption. All subjects were given an alcoholic drink of 0.4 g ethanol /kg of body weight. Blood venous samples were collected at baseline, and 30, 60, 90 and 120 minutes after ingestion...
July 21, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28714907/genetic-contribution-to-alcohol-dependence-investigation-of-a-heterogeneous-german-sample-of-individuals-with-alcohol-dependence-chronic-alcoholic-pancreatitis-and-alcohol-related-cirrhosis
#2
Jens Treutlein, Josef Frank, Fabian Streit, Céline S Reinbold, Dilafruz Juraeva, Franziska Degenhardt, Liz Rietschel, Stephanie H Witt, Andreas J Forstner, Monika Ridinger, Jana Strohmaier, Norbert Wodarz, Helene Dukal, Jerome C Foo, Per Hoffmann, Stefan Herms, Stefanie Heilmann-Heimbach, Michael Soyka, Wolfgang Maier, Wolfgang Gaebel, Norbert Dahmen, Norbert Scherbaum, Bertram Müller-Myhsok, Susanne Lucae, Marcus Ising, Felix Stickel, Thomas Berg, Ulla Roggenbuck, Karl-Heinz Jöckel, Henrike Scholz, Ulrich S Zimmermann, Stephan Buch, Wolfgang H Sommer, Rainer Spanagel, Benedikt Brors, Sven Cichon, Karl Mann, Falk Kiefer, Jochen Hampe, Jonas Rosendahl, Markus M Nöthen, Marcella Rietschel
The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (puncorrected = 1.2 × 10(-6); pcorrected = 0.020). This was driven by the AD subsample...
July 17, 2017: Genes
https://www.readbyqxmd.com/read/28662358/interaction-between-the-adh1b-3-allele-and-drinking-motives-on-alcohol-use-among-black-college-students
#3
Michelle J Zaso, Jessica M Desalu, Jueun Kim, Kavita Suryadevara, John M Belote, Aesoon Park
BACKGROUND: Black young adults have lower rates of alcohol use than other racial groups. Genetic factors may protect against drinking. Specifically, the ADH1B*3 allele is present almost exclusively in Black populations and has been protective against alcohol use and alcohol use disorder. The protective effects of the ADH1B*3 allele, however, may differ as a function of alcohol-promoting cognitions. OBJECTIVES: The current study examined whether ADH1B*3 moderated relations of drinking motives with alcohol consumption among Black college drinkers...
June 29, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28657176/an-improved-pcr-ctpp-assay-for-the-detection-of-adh1b-arg48his-polymorphism
#4
Shupeng Jiang, Yongqing Tong, Rui Zhao, Ge Xiong, Bin Qiao, Yan Li
BACKGROUND: ADH1B Arg48His polymorphism is associated with the development of alcohol-related diseases. In this study, we aimed to explore an improved polymerase chain reaction with confronting two-pair primers (PCR-CTPP) assay for the detection of ADH1B Arg48His polymorphism. METHODS: A mismatch was introduced at the 3' end of each of the two allele-specific to increase the specificity of the reaction. But beyond that, a new mismatch at-3 positions of outer primers was designed to decrease the efficiency of the aforementioned primers and depresses the amplification of an internal nonspecific DNA control...
June 28, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28645180/alcohol-metabolism-and-oesophageal-cancer-a-systematic-review-of-the-evidence
#5
Marco Matejcic, M J Gunter, Pietro Ferrari
Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review of current epidemiological evidence of the relationship between alcohol intake and OC risk, including the role of tobacco smoking and functional polymorphisms of dehydrogenases (ADHs) and aldehyde dehydrogenases (ALDHs)...
June 22, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28610454/genetic-polymorphisms-of-alcohol-metabolizing-enzymes-and-their-association-with-alcoholism-risk-personality-and-anthropometric-traits-among-malaysian-university-students
#6
Hing-Huat Ong, Foong-Vai Khor, Kausalyah Balasupramaniam, Yee-How Say
Three single nucleotide polymorphisms (SNPs) in alcohol-metabolizing genes - ADH1B (Arg47His), ADH1C (Ile350Val) and ALDH2 (Glu504Lys) have been extensively associated with flush reaction and alcoholism. Therefore, we investigated the association of these three SNPs with alcohol-induced reactions (AIRs), alcoholism risk, personality and anthropometric traits among Malaysian university students. AIRs, Self-Rating of the Effects of Alcohol (SRE) and Ten-Item Personality were surveyed, anthropometric measurements and DNA samples were taken...
June 14, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28607029/age-dependent-protein-abundance-of-cytosolic-alcohol-and-aldehyde-dehydrogenases-in-human-liver
#7
Deepak Kumar Bhatt, Andrea Gaedigk, Robin E Pearce, J Steven Leeder, Bhagwat Prasad
Hepatic cytosolic alcohol and aldehyde dehydrogenases (ADHs and ALDHs) catalyze the biotransformation of xenobiotics (e.g., cyclophosphamide and ethanol) and vitamin A. Because age-dependent hepatic abundance of these proteins is unknown, we quantified protein expression of ADHs and ALDH1A1 in a large cohort of pediatric and adult human livers by LC-MS/MS proteomics. Purified proteins were used as calibrators. Two to three surrogate peptides per protein were quantified in trypsin digests of liver cytosolic samples and calibrator proteins under optimal conditions of reproducibility...
June 12, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28586067/prognosis-genes-in-gastric-adenocarcinoma-identified-by-cross-talk-genes-in-disease%C3%A2-related-pathways
#8
Lizhi Zhao, Haichun Lei, Li Shen, Jiquan Tang, Zhiwei Wang, Weisong Bai, Feng Zhang, Shouli Wang, Weihua Li
The aim of the present study was to investigate the prognostic value of genes that participate in the development of gastric adenocarcinoma, via exploring gene cross talk in disease‑related pathways. Differentially expressed genes (DEGs) in the gastric samples were identified by analyzing the expression data downloaded from the GEO database. The DEGs were subjected to the human protein‑protein interaction (PPI) network to construct the PPI network of DEGs, which was then used for the identification of key genes in cancer samples via the expression deviation score and degree in the network...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28566767/independent-effects-of-adh1b-and-aldh2-common-dysfunctional-variants-on-gout-risk
#9
Masayuki Sakiyama, Hirotaka Matsuo, Airi Akashi, Seiko Shimizu, Toshihide Higashino, Makoto Kawaguchi, Akiyoshi Nakayama, Mariko Naito, Sayo Kawai, Hiroshi Nakashima, Yutaka Sakurai, Kimiyoshi Ichida, Toru Shimizu, Hiroshi Ooyama, Nariyoshi Shinomiya
Gout is caused by hyperuricemia, with alcohol consumption being an established risk factor. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are crucial enzymes for alcohol metabolism. We recently performed a genome-wide association study of gout and a subsequent fine-mapping study which identified rs671 of ALDH2 as a gout locus. However, the association between gout and common variants of ADH1B has hitherto remained unreported, prompting us to investigate the association between gout and common dysfunctional variants of ADH1B (rs1229984) and ALDH2 (rs671)...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28534462/associations-between-alcohol-dehydrogenase-genes-and-alcohol-use-across-early-and-middle-adolescence-moderation-%C3%A3-preventive-intervention
#10
H Harrington Cleveland, Gabriel L Schlomer, David J Vandenbergh, Pedro S A Wolf, Mark E Feinberg, Mark T Greenberg, Richard L Spoth, Cleve Redmond
Data from the in-school sample of the PROSPER preventive intervention dissemination trial were used to investigate associations between alcohol dehydrogenase genes and alcohol use across adolescence, and whether substance misuse interventions in the 6th and 7th grades (targeting parenting, family functioning, social norms, youth decision making, and peer group affiliations) modified associations between these genes and adolescent use. Primary analyses were run on a sample of 1,885 individuals and included three steps...
May 23, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28494133/interaction-between-adh1b-3-and-alcohol-facilitating-social-environments-in-alcohol-behaviors-among-college-students-of-african-descent
#11
Jessica M Desalu, Michelle J Zaso, Jueun Kim, John M Belote, Aesoon Park
BACKGROUND AND OBJECTIVES: Although alcohol-facilitating social environmental factors, such as alcohol offers and high perceived peer drinking norms, have been extensively studied as determinants of college drinking, their role among college students of African descent remains understudied. Furthermore, gene-environment interaction research suggests that the effects of alcohol-facilitating environments may differ as a function of genetic factors. Specifically, the alcohol dehydrogenase gene's ADH1B*3 allele, found almost exclusively in persons of African descent, may modulate the association of risky social environments with alcohol behaviors...
June 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28485404/genetic-contributors-to-variation-in-alcohol-consumption-vary-by-race-ethnicity-in-a-large-multi-ethnic-genome-wide-association-study
#12
E Jorgenson, K K Thai, T J Hoffmann, L C Sakoda, M N Kvale, Y Banda, C Schaefer, N Risch, J Mertens, C Weisner, H Choquet
Alcohol consumption is a complex trait determined by both genetic and environmental factors, and is correlated with the risk of alcohol use disorders. Although a small number of genetic loci have been reported to be associated with variation in alcohol consumption, genetic factors are estimated to explain about half of the variance in alcohol consumption, suggesting that additional loci remain to be discovered. We conducted a genome-wide association study (GWAS) of alcohol consumption in the large Genetic Epidemiology Research in Adult Health and Aging (GERA) cohort, in four race/ethnicity groups: non-Hispanic whites, Hispanic/Latinos, East Asians and African Americans...
May 9, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28403188/molecular-pathways-associated-with-blood-pressure-and-hexadecanedioate-levels
#13
Cristina Menni, Sarah J Metrustry, Georg Ehret, Anna F Dominiczak, Phil Chowienczyk, Tim D Spector, Sandosh Padmanabhan, Ana M Valdes
The dicarboxylic acid hexadecanedioate is associated with increased blood pressure (BP) and mortality in humans and feeding it to rats raises BP. Here we aim to characterise the molecular pathways that influence levels of hexadecanedioate linked to BP regulation, using genetic and transcriptomic studies. The top associations for hexadecanedioate in a genome-wide association scan (GWAS) conducted on 6447 individuals from the TwinsUK and KORA cohorts were tested for association with BP and hypertension in the International Consortium for BP and in a GWAS of BP extremes...
2017: PloS One
https://www.readbyqxmd.com/read/28361821/candidate-genes-for-alcohol-dependence-a-genetic-association-study-from-india
#14
Savita Malhotra, Debasish Basu, Madhu Khullar, Abhishek Ghosh, Neera Chugh
BACKGROUND & OBJECTIVES: Search for candidate genes for alcohol dependence (AD) has been inconsistent and inconclusive. Moreover, most of the research has been confined to a few specific ethnic groups. Hence, the aim of our study was to explore specific candidate genes for AD in north Indian male population. METHODS: In this clinic-based genetic association study, 210 males with AD and 200 controls matched for age, gender and ethnicity were recruited from the clinic and the general population, respectively...
November 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28349588/adh1b-from-alcoholism-natural-selection-and-cancer-to-the-human-phenome
#15
REVIEW
Renato Polimanti, Joel Gelernter
The ADH1B (Alcohol Dehydrogenase 1B (class I), Beta Polypeptide) gene and its best-known functional alleles, Arg48His (rs1229984, ADH1B*2) and Arg370Cys (rs2066702, ADH1B*3), have been investigated in relation to many phenotypic traits; most frequently including alcohol metabolism and alcohol drinking behaviors, but also human evolution, liver function, cancer, and, recently, the comprehensive human phenome. To understand ADH1B functions and consequences, we provide here a bioinformatic analysis of its gene regulation and molecular functions, literature review of studies focused on this gene, and a discussion regarding future research perspectives...
March 27, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28295416/validating-harmful-alcohol-use-as-a-phenotype-for-genetic-discovery-using-phosphatidylethanol-and-a-polymorphism-in-adh1b
#16
Amy C Justice, Kathleen A McGinnis, Janet P Tate, Ke Xu, William C Becker, Hongyu Zhao, Joel Gelernter, Henry R Kranzler
BACKGROUND: Although alcohol risk is heritable, few genetic risk variants have been identified. Longitudinal electronic health record (EHR) data offer a largely untapped source of phenotypic information for genetic studies, but EHR-derived phenotypes for harmful alcohol exposure have yet to be validated. Using a variant of known effect, we used EHR data to develop and validate a phenotype for harmful alcohol exposure that can be used to identify unknown genetic variants in large samples...
May 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28236470/effect-of-alcohol-and-its-metabolites-in-lung-cancer-capua-study
#17
Sara M Álvarez-Avellón, Ana Fernández-Somoano, Eva M Navarrete-Muñoz, Jesús Vioque, Adonina Tardón
BACKGROUND AND OBJECTIVE: Alcohol and its metabolites play an important role in carcinogenesis. This effect could be modulated by polymorphisms in genes encoding enzymes involved in the metabolism of alcohol and folate. Therefore, we analyzed the effect of alcohol consumption and ADH1B Arg48His, ADH1B Arg370Cys, ADH1C Ile349Val, ALDH2 Glu540Lys, CYP2E1 RsaI, CYP2E1 DraI, CYP2E1 TaqI and MTHFR C677T polymorphisms on the risk of developing lung cancer. PATIENTS AND METHODS: We included 876 lung cancer cases and 840 controls of the CAPUA hospital-based case-control study...
June 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28212614/transcriptomic-profiling-provides-molecular-insights-into-hydrogen-peroxide-induced-adventitious-rooting-in-mung-bean-seedlings
#18
Shi-Weng Li, Yan Leng, Rui-Fang Shi
BACKGROUND: Hydrogen peroxide (H2O2) has been known to function as a signalling molecule involved in the modulation of various physiological processes in plants. H2O2 has been shown to act as a promoter during adventitious root formation in hypocotyl cuttings. In this study, RNA-Seq was performed to reveal the molecular mechanisms underlying H2O2-induced adventitious rooting. RESULTS: RNA-Seq data revealed that H2O2 treatment greatly increased the numbers of clean reads and expressed genes and abundance of gene expression relative to the water treatment...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212515/combination-of-aldh2-and-adh1b-polymorphisms-is-associated-with-smoking-initiation-a-large-scale-cross-sectional-study-in-a-japanese-population
#19
Hiroyuki Masaoka, Hidemi Ito, Silvano Gallus, Miki Watanabe, Akira Yokomizo, Masatoshi Eto, Keitaro Matsuo
BACKGROUND: Aldehyde dehydrogenase 2 (ALDH2; rs671, Glu504Lys) and alcohol dehydrogenase 1B (ADH1B; rs1229984, His47Arg) polymorphisms are known to strongly influence alcohol drinking behavior. Given evidence of an association between smoking and drinking behaviors, we hypothesized that ALDH2/ADH1B polymorphisms might also be associated with smoking initiation, and conducted a cross-sectional study to examine this hypothesis. METHODS: Study subjects were first-visit outpatients diagnosed not to have cancer at Aichi Cancer Center Hospital between 2001 and 2005, including 4141 never smokers and 2912 ever smokers...
April 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28182702/natural-formulas-and-the-nature-of-formulas-exploring-potential-therapeutic-targets-based-on-traditional-chinese-herbal-formulas
#20
Qianru Zhang, Hua Yu, Jin Qi, Daisheng Tang, Xiaojia Chen, Jian-Bo Wan, Peng Li, Hao Hu, Yi-Tao Wang, Yuanjia Hu
By comparing the target proteins (TPs) of classic traditional Chinese medicine (TCM) herbal formulas and modern drugs used for treating coronary artery disease (CAD), this study aimed to identify potential therapeutic TPs for treating CAD. Based on the theory of TCM, the Xuefu-Zhuyu decoction (XZD) and Gualou-Xiebai-Banxia decoction (GXBD), both of which are classic herbal formulas, were selected for treating CAD. Data on the chemical ingredients and corresponding TPs of the herbs in these two formulas and data on modern drugs approved for treating CAD and related TPs were retrieved from professional TCM and bioinformatics databases...
2017: PloS One
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