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L Ma, Z N Lu
In the present study, we investigated the association between ADH1B rs1229984 and ALDH2 rs671 polymorphisms and the development of Alzheimer's disease in a Chinese population. Genotyping of the ADH1B rs1229984 and ALDH2 rs671 polymorphisms was carried out by polymerase chain reaction-restriction fragment length polymorphism. Logistic regression analyses revealed that the AA genotype of ADH1B rs1229984 was associated with an increased risk of Alzheimer's disease (OR = 2.54, 95%CI = 1.19-5.41). In addition, ADH1B rs1229984 was also associated with elevated risk of Alzheimer's disease in both dominant (OR = 1...
October 5, 2016: Genetics and Molecular Research: GMR
Kae Koganebuchi, Kuniaki Haneji, Takashi Toma, Keiichiro Joh, Hidenobu Soejima, Kazuma Fujimoto, Hajime Ishida, Motoyuki Ogawa, Tsunehiko Hanihara, Shoji Harada, Shoji Kawamura, Hiroki Oota
OBJECTIVES: A cline of frequencies of the derived allele of the ALDH2 gene, which causes a deficiency of an enzyme and "facial flushing" in humans who drink alcohol, has been known among the people of the Japanese archipelago. This cline is conventionally explained by admixture with immigrants from the Asian continent occurring during the Yayoi period. Previous studies lack sufficient data from the peripheral regions of the indigenous Jomon people, and those data the ADH1B gene that is involved in the Class I ADH gene cluster and contains another variant leading to a functional change...
November 1, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
Tomoyuki Shibata, Hiromi Yamashita, Tomohiko Kawamura, Yasutaka Jodai, Takafumi Omori, Kazuya Sumi, Yuichiro Ichikawa, Masaaki Okubo, Takamitsu Ishizuka, Tomomitsu Tahara, Mitsuo Nagasaka, Yoshihito Nakagawa, Ichiro Hirata, Naoki Ohmiya, Makoto Nakao
The aim of this study was to investigate the effect of consuming small amounts of beer or a nonalcoholic beer taste beverage (non-beer) on gastric emptying and the polymorphisms in alcohol metabolism-related enzyme-encoding genes. Twenty male healthy volunteers were questioned regarding their alcohol consumption status, and body measurement was performed. The genetic polymorphisms in ADH1B (rs1229984, Arg47His) and ALDH2 (rs671 Glu487Lys) were analyzed. The subjects consumed 150 mL of beer or non-beer once per week, followed by the ingestion of 200 kcal of the test nutrient containing (13)C-acetate 15 min later, after which the subjects' exhalations were collected up to 120 min...
2016: Biomedical Research
S Sookoian, D Flichman, G O Castaño, C J Pirola
BACKGROUND: Previous epidemiological studies suggest that patients diagnosed with nonalcoholic fatty liver disease (NAFLD) who drink light to moderate amounts of alcohol (up to ~30 g per day) have less severe histological lesions compared with nondrinkers. However, while the cross-sectional nature of current evidence precludes assessment of causality, cumulative lifetime-exposure of moderate alcohol consumption on histological outcomes has never been evaluated. AIM: To overcome these limitations, a Mendelian randomisation study was performed using a validated genetic variant (rs1229984 A;G) in the alcohol dehydrogenase (ADH1B) gene as a proxy of long-term alcohol exposure...
December 2016: Alimentary Pharmacology & Therapeutics
Q Zhong, R R Wu, Z M Zeng
Human colorectal cancer (CRC) is a major worldwide health concern, and its development has been shown to be associated with alcohol intake. We carried out a study to investigate the effect of the ADH1B Arg47His and ALDH2 Glu487Lys genetic polymorphisms and their interaction with alcohol consumption on development of CRC. Between March 2013 and May 2015, a total of 274 CRC patients and 358 healthy controls were recruited. Genotyping of sequence variations was performed using the polymerase chain reaction-restriction fragment length polymorphism method...
September 23, 2016: Genetics and Molecular Research: GMR
Daxu Li, Ruizhi Zhang, Tianbo Jin, Na He, Le Ren, Zhe Zhang, Qingna Zhang, Ran Xu, Hong Tao, Guang Zeng, Jing Gao
In this study, we assessed the association between single nucleotide polymorphisms (SNPs) in candidate genes and the prognosis of laryngeal cancer (LC) patients. Thirty-seven SNPs in 26 genes were genotyped in 170 male Han Chinese patients with LC. The effects of the candidate genes on the prognosis of LC patients were evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. The GA genotype of rs1229984 (hazard ratio [HR], 0.537; 95% confidence interval [CI], 0.340-0.848; p = 0.008) in alcohol dehydrogenase 1B (ADH1B), and the AA genotype of rs9929218 (HR, 6...
September 28, 2016: Oncotarget
Yu-Chou Chi, Shou-Lun Lee, Ching-Long Lai, Yung-Pin Lee, Shiao-Pieng Lee, Chien-Ping Chiang, Shih-Jiun Yin
Alcohol dehydrogenase (ADH) is the principal enzyme responsible for metabolism of ethanol. Human ADH constitutes a complex isozyme family with striking variations in kinetic function and tissue distribution. Liver and gastrointestinal tract are the major sites for first-pass metabolism (FPM). Their relative contributions to alcohol FPM and degrees of the inhibitions by aspirin and its metabolite salicylate, acetaminophen and cimetidine remain controversial. To address this issue, mathematical organ modeling of ethanol-oxidizing activities in target tissues and that of the ethanol-drug interactions were constructed by linear combination of the corresponding numerical rate equations of tissue constituent ADH isozymes with the documented isozyme protein contents, kinetic parameters for ethanol oxidation and the drug inhibitions of ADH isozymes/allozymes that were determined in 0...
October 25, 2016: Chemico-biological Interactions
C Menni, S Metrustry, G Ehret, A F Dominiczak, P Chowienczyk, T D Spector, S Padmanabhan, A M Valdes
OBJECTIVE: The dicarboxylic fatty acid hexadecanedioate is functionally associated with increased blood pressure. The aims of this study was to further characterize which pathways are related to this compound using genetic and transcriptomic data. DESIGN AND METHOD: A genome-wide association scan (GWAS) was conducted on 6447 individuals from the TwinsUK and KORA cohorts. SNPs achieving genome-wide significance were then tested in the International Consortium for Blood Pressure and in a GWAS of extremes of blood pressure...
September 2016: Journal of Hypertension
Ning Mao, Siyao Nie, Bin Hong, Chao Li, Xueyuan Shen, Tao Xiong
BACKGROUND: It has been shown that gene polymorphisms may play an important role in the carcinogenesis of esophageal cancer. This study is to investigate the role of alcohol dehydrogenase 1B (ADH1B) gene Arg47His polymorphism in esophageal cancer susceptibility. METHODS: Case-control studies published between January 2000 and June 2015 were searched to retrieve relevant articles. The pooled odds ratio (OR) and 95 % confidence interval (CI) were employed to calculate the strength of association...
2016: World Journal of Surgical Oncology
Cassie Yu, Jon McClellan
Substance abuse disorders have a strong genetic component. Genetic risk factors associated with alcohol abuse include common variants in genes coding for alcohol-metabolizing enzymes and gamma-aminobutyric acid A receptors. Functional missense mutations in ADH1B and ALDH2 are protective against alcohol dependence. Nicotine use disorders are associated with polymorphisms in a cluster of nicotinic acetylcholine receptors on chromosome 15q24, and mutations that reduce the enzymatic activity of CYP2A6. Genetic risk factors for other illicit drug use have not been well-studied...
July 2016: Child and Adolescent Psychiatric Clinics of North America
Guang Yin, Mariko Naito, Kenji Wakai, Emi Morita, Sayo Kawai, Nobuyuki Hamajima, Sadao Suzuki, Yoshikuni Kita, Toshiro Takezaki, Keitaro Tanaka, Makiko Morita, Hirokazu Uemura, Etsuko Ozaki, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, Hideo Tanaka
Associations between alcohol consumption and type 2 diabetes risk are inconsistent in epidemiologic studies. This study investigated the associations of ADH1B and ALDH2 polymorphisms with fasting blood glucose levels, and the impact of the associations of alcohol consumption with fasting blood glucose levels in Japanese individuals. This cross-sectional study included 907 men and 912 women, aged 35-69 years. The subjects were selected from among the Japan Multi-institutional Collaborative Cohort study across six areas of Japan...
May 2016: Nagoya Journal of Medical Science
E S Kuznetsova, O L Zinovieva, N Yu Oparina, M M Prokofjeva, P V Spirin, I A Favorskaya, I B Zborovskaya, N A Lisitsyn, V S Prassolov, T D Mashkova
Retinoids are signaling molecules that control a wide variety of cellular processes and possess antitumor activity. This work presents a comprehensive description of changes in the expression of 23 genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer tumors compared to adjacent normal tissues obtained using RT-PCR. Even at early stages of malignant transformation, a significant decrease in ADH1B, ADH3, RDHL, and RALDH1 mRNA levels was observed in 82, 79, 73, and 64% of tumor specimens, respectively, and a considerable increase in AKR1B10 mRNA content was observed in 80% of tumors...
March 2016: Molekuliarnaia Biologiia
Renato Polimanti, Henry R Kranzler, Joel Gelernter
To identify novel traits associated with alleles known to predispose to alcohol and nicotine use, we conducted a phenome-wide association study (PheWAS) in a large multi-population cohort. We investigated 7688 African-Americans, 1133 Asian-Americans, 14 081 European-Americans, and 3492 Hispanic-Americans from the Women's Health Initiative, analyzing alleles at the CHRNA3-CHRNA5 locus, ADH1B, and ALDH2 with respect to phenotypic traits related to anthropometric characteristics, dietary habits, social status, psychological traits, reproductive history, health conditions, and nicotine/alcohol use...
October 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Zhanlong Shen, Bo Wang, Jianyuan Luo, Kewei Jiang, Hui Zhang, Harri Mustonen, Pauli Puolakkainen, Jun Zhu, Yingjiang Ye, Shan Wang
UNLABELLED: Lysine acetylated modification was indicated to impact colorectal cancer (CRC)'s distant metastasis. However, the global acetylated proteins in CRC and the differential expressed acetylated proteins and acetylated sites between CRC primary and distant metastatic tumor remains unclear. Our aim was to construct a complete atlas of acetylome in CRC and paired liver metastases. Combining high affinity enrichment of acetylated peptides with high sensitive mass spectrometry, we identified 603 acetylation sites from 316 proteins, among which 462 acetylation sites corresponding to 243 proteins were quantified...
June 16, 2016: Journal of Proteomics
Karen G Chartier, Danielle M Dick, Laura Almasy, Grace Chan, Fazil Aliev, Marc A Schuckit, Denise M Scott, John Kramer, Kathleen K Bucholz, Laura J Bierut, John Nurnberger, Bernice Porjesz, Victor M Hesselbrock
OBJECTIVE: Variations in the genes encoding alcohol dehydrogenase (ADH) enzymes are associated with both alcohol consumption and dependence in multiple populations. Additionally, some environmental factors have been recognized as modifiers of these relationships. This study examined the modifying effect of religious involvement on relationships between ADH gene variants and alcohol consumption-related phenotypes. METHOD: Subjects were African American, European American, and Hispanic American adults with lifetime exposure to alcohol (N = 7,716; 53% female) from the Collaborative Study on the Genetics of Alcoholism...
May 2016: Journal of Studies on Alcohol and Drugs
Tamara L Wall, Susan E Luczak, Susanne Hiller-Sturmhöfel
Gene variants encoding several of the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), are among the largest genetic associations with risk for alcohol dependence. Certain genetic variants (i.e., alleles)--particularly the ADH1B*2, ADH1B*3, ADH1C*1, and ALDH2*2 alleles--have been associated with lower rates of alcohol dependence. These alleles may lead to an accumulation of acetaldehyde during alcohol metabolism, which can result in heightened subjective and objective effects...
2016: Alcohol Research: Current Reviews
Akira Yokoyama, Yoko Kamada, Hiromi Imazeki, Emiko Hayashi, Shigenori Murata, Kenji Kinoshita, Tetsuji Yokoyama, Yoshinori Kitagawa
BACKGROUND: The genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH2) are associated with the risk of alcoholism and upper aerodigestive tract cancer in alcoholics. Salivary ethanol (sEtOH) levels are well correlated with blood EtOH levels. METHODS: To study the effects of ADH1B and ALDH2 genotypes on the alcohol elimination rate (AER) and salivary acetaldehyde (sAcH) levels, we measured the sEtOH and sAcH levels twice at a 1-hour intervals in 99 intoxicated Japanese alcoholic men who had stopped drinking for 4 or more hours...
June 2016: Alcoholism, Clinical and Experimental Research
Janne Schurmann Tolstrup, Marie Kim Wium-Andersen, David Dynnes Ørsted, Børge Grønne Nordestgaard
BACKGROUND: The aim of this study was to test the hypothesis that alcohol consumption, both observational (self-reported) and estimated by genetic instruments, is associated with a risk of atrial fibrillation and to determine whether people with high cardiovascular risk are more sensitive towards alcohol than people with low risk. METHODS: We used data for a total of 88,782 men and women from the Copenhagen City Heart Study 1991-1994 and 2001-2003 and the Copenhagen General Population Study 2003-2010...
September 2016: European Journal of Preventive Cardiology
Eléonore A Attignon, Alix F Leblanc, Béatrice Le-Grand, Caroline Duval, Martine Aggerbeck, Hélène Rouach, Etienne B Blanc
The mechanisms by which pollutants participate in the development of diverse pathologies are not completely understood. The pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activates the AhR (aryl hydrocarbon receptor) signaling pathway. We previously showed that TCDD (25 nM, 30 h) decreased the expression of several alcohol metabolism enzymes (cytochrome P450 2E1, alcohol dehydrogenases ADH1, 4 and 6) in differentiated human hepatic cells (HepaRG). Here, we show that, as rapidly as 8 h after treatment (25 nM TCDD) ADH expression decreased 40 % (p < 0...
April 8, 2016: Archives of Toxicology
Kenichi Kagemoto, Yuji Urabe, Tomohiro Miwata, Shiro Oka, Hidenori Ochi, Yasuhiko Kitadai, Shinji Tanaka, Kazuaki Chayama
A previous genome-wide association study identified two novel esophageal squamous cell carcinoma (ESCC) susceptibility genes, ADH1B and ALDH2. We investigated the characteristics of ESCC, and the relationship between metachronous esophageal and/or pharyngeal squamous cell carcinoma (SCC) and the ADH1B & ALDH2 risk alleles. One hundred and seventeen superficial ESCC patients who underwent treatment with endoscopic submucosal dissection (ESD) were followed up using endoscopy for ≥12 months. First, we performed a replication analysis to confirm the relationship between ESCC and the ADH1B & ALDH2 risk alleles using 117 superficial ESCC cases and 1125 healthy controls...
July 2016: Cancer Medicine
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