keyword
MENU ▼
Read by QxMD icon Read
search

DRD4 VNTR

keyword
https://www.readbyqxmd.com/read/28900390/genetically-driven-enhancement-of-dopaminergic-transmission-affects-moral-acceptability-in-females-but-not-in-males-a-pilot-study
#1
Silvia Pellegrini, Sara Palumbo, Caterina Iofrida, Erika Melissari, Giuseppina Rota, Veronica Mariotti, Teresa Anastasio, Andrea Manfrinati, Rino Rumiati, Lorella Lotto, Michela Sarlo, Pietro Pietrini
Moral behavior has been a key topic of debate for philosophy and psychology for a long time. In recent years, thanks to the development of novel methodologies in cognitive sciences, the question of how we make moral choices has expanded to the study of neurobiological correlates that subtend the mental processes involved in moral behavior. For instance, in vivo brain imaging studies have shown that distinct patterns of brain neural activity, associated with emotional response and cognitive processes, are involved in moral judgment...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28797200/the-polymorphism-of-dopamine-receptor-d4-drd4-and-dopamine-transporter-dat-genes-in-the-men-with-antisocial-behavior-and-mixed-martial-arts-fighters
#2
Elena Cherepkova, Vladimir Maksimov, Alexandr Kushnarev, Igor Shakhmatov, Lyubomir I Aftanas
OBJECTIVES: VNTR polymorphisms of DRD4 and DAT genes were studied in the Russian and Chechen men convicted of crimes, and two control groups comprised of the MMA fighters and a sample of general population. A group of MMA fighters included only the subjects without history of antisocial behavior. METHODS: DNA was isolated by phenol-chloroform extraction from the blood. Genotyping VNTR polymorphisms of the DRD4 and DAT genes were performed by PCR on published methods...
August 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28745671/-a-role-of-interactions-between-n-methyl-d-aspartate-and-dopamine-receptors-in-facial-emotion-recognition-impairment-in-schizophrenia
#3
M V Alfimova, V E Golimbet, G I Korovaitseva, T V Lezheiko, D V Tikhonov, T K Ganisheva, N B Berezin, A A Snegireva, T K Shemiakina
AIM: To search for genetic mechanisms of facial emotion recognition (FER) impairment, one of the features of schizophrenia that affects social adaptation of patients. Based on the view implicating the interplay between dopaminergic and glutamatergic systems into the pathogenesis of schizophrenia, authors explored the interaction effects of the C366G polymorphism in the GRIN2B gene encoding NMDA receptor subunit NR2B with ANKK1/DRD2 Taq1A and 48-VNTR DRD4 polymorphisms on FER. MATERIAL AND METHODS: GRIN2B -DRD2 interaction effects were studied in a sample of 237 patients and 235 healthy controls, GRIN2B - DRD4 in 268 patients and 208 controls...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28727140/respiratory-sinus-arrhythmia-in-the-fourth-decade-of-life-depends-on-birth-weight-and-the-drd4-gene-implications-for-understanding-the-development-of-emotion-regulation
#4
Calan Savoy, Karen J Mathewson, Louis A Schmidt, Katherine M Morrison, John E Krzeczkowski, Ryan J Van Lieshout
INTRODUCTION: The long allele of the DRD4 gene can confer different behavioral and emotional phenotypes depending upon environmental exposure, although the physiological changes underlying these phenotypes are not fully known. We sought to extend this work by assessing the interaction of the DRD4 gene and exposure to perinatal adversity (indexed by extremely low birth weight [ELBW]) on resting respiratory sinus arrhythmia (RSA), a neurophysiological measure of emotion regulation, in adulthood...
July 20, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28630890/drd4-gene-polymorphisms-as-a-risk-factor-for-children-with-attention-deficit-hyperactivity-disorder-in-iranian-population
#5
Seyed Mahmoud Tabatabaei, Shahrokh Amiri, Sara Faghfouri, Seyed Gholamreza Noorazar, Shahin AbdollahiFakhim, Ali Fakhari
BACKGROUND AND OBJECTIVE: Dopamine dysfunction is known to be associated with attention deficit hyperactivity disorder (ADHD). Dopamine D4 receptor gene (DRD4) is one of the important genes in this pathway. This study intended to investigate the variable number of tandem repeats (VNTR) in exon 3 of the DRD4 gene in Iranian children and adolescents. MATERIALS AND METHODS: In this study, 130 children with ADHD, aged 6-14 years, and 130 healthy children, within the same age range, were enrolled...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28428702/drd4-and-dat1-vntr-genotyping-in-children-with-attention-deficit-hyperactivity-disorder
#6
Ashley Stanley, K Chavda, A Subramanian, S V Prabhu, T F Ashavaid
The dopamine receptor-D4 and the dopamine transporter have been investigated for their role in attention deficit hyperactivity disorder (ADHD) in children. Reports of their genetic association with ADHD have shown mixed results. The aim of the study was to evaluate the association of variable number tandem repeats (VNTRs) of the DRD4 and DAT1 genes with ADHD in children. A pilot 1:1 case control study, with 44 clinically confirmed ADHD cases and 44 age/gender matched healthy controls, was conducted at a tertiary care centre in Mumbai...
June 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28282463/family-based-association-study-of-drd4-gene-in-methylphenidate-responded-attention-deficit-hyperactivity-disorder
#7
Patrick Wing-Leung Leung, Janice Ka Yan Chan, Lu Hua Chen, Chi Chiu Lee, Se Fong Hung, Ting Pong Ho, Chun Pan Tang, Robert K Moyzis, James M Swanson
The 48-basepair (48-bp) variable number tandem repeat (VNTR) polymorphism in exon 3 of the dopamine receptor D4 gene (DRD4) is implicated in the etiology of attention-deficit/ hyperactivity disorder (ADHD). In particular, ADHD in European-ancestry population is associated with an increased prevalence of the 7-repeat (7R) allele of the exon 3 VNTR. However, it is intriguing to note that the 7R allele has been found to be of very low prevalence in the Chinese general population. In a previous case-control study, our research team had found that the 7R allele was similarly absent in Chinese ADHD children in Hong Kong...
2017: PloS One
https://www.readbyqxmd.com/read/27909828/the-dopamine-related-polymorphisms-bdnf-comt-drd2-drd3-and-drd4-are-not-linked-with-changes-in-csf-dopamine-levels-and-frequency-of-hiv-infection
#8
Anne Horn, C Scheller, S du Plessis, R Burger, G Arendt, J Joska, S Sopper, C M Maschke, M Obermann, I W Husstedt, J Hain, P Riederer, E Koutsilieri
We showed previously that higher levels in CSF dopamine in HIV patients are associated with the presence of the dopamine transporter (DAT) 10/10-repeat allele which was also detected more frequently in HIV-infected individuals compared to uninfected subjects. In the current study, we investigated further whether other genetic dopamine (DA)-related polymorphisms may be related with changes in CSF DA levels and frequency of HIV infection in HIV-infected subjects. Specifically, we studied genetic polymorphisms of brain-derived neurotrophic factor, catechol-O-methyltransferase, and dopamine receptors DRD2, DRD3, and DRD4 genetic polymorphisms in uninfected and HIV-infected people in two different ethnical groups, a German cohort (Caucasian, 72 individuals with HIV infection and 22 individuals without HIV infection) and a South African cohort (Xhosan, 54 individuals with HIV infection and 19 individuals without HIV infection)...
December 1, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27497990/polymorphisms-of-dopamine-receptor-genes-and-risk-of-visual-hallucinations-in-parkinson-s-patients
#9
M Ferrari, C Comi, F Marino, L Magistrelli, F De Marchi, R Cantello, G Riboldazzi, G Bono, M Cosentino
BACKGROUND: Visual hallucinations (VHs) are frequent non-motor complication of Parkinson's disease (PD), associated to a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (DR) variants and psychosis in Alzheimer's disease, addictions, schizophrenia, and bipolar disorder. However, there are only a few studies on DR variants and VHs in PD, which did not provide conclusive results. OBJECTIVES: The present study aimed to determine whether genetic differences of DR are associated with visual hallucinations (VHs) in a cohort of Parkinson's disease (PD) patients...
November 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27494520/dopamine-receptor-gene-drd4-7-repeat-allele-x-maternal-sensitivity-interaction-on-child-externalizing-behavior-problems-independent-replication-of-effects-at-18-months
#10
Anthony P King, Maria Muzik, Lindsay Hamilton, Alexander B Taylor, Katherine L Rosenblum, Israel Liberzon
The DRD4 VNTR has been associated with child behavior problems in interaction with maternal insensitivity in European and American cohorts of preschoolers, with the 7-repeat (7R) allele associated with greater problems. We sought to replicate and expand these findings by examining effects on reports of child behavior problems at 18 months. A 63 family sample with data for observed maternal sensitivity ratings, DRD4 VNTR genotype, and maternal report of child behavior problems at 18-months was used in this preliminary analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27267123/sexual-trauma-the-dopamine-d4-receptor-and-suicidal-ideation-among-hospitalized-adolescents-a-preliminary-investigation
#11
James Doorley, Caitlin Williams, Travis Mallard, Christianne Esposito-Smythers, John McGeary
Though an association exists between sexual trauma and adolescent suicidal thoughts and behaviors (STBs), not all adolescents with a sexual assault history develop STBs. The present study examined whether carrier status of the DRD4 VNTR polymorphism (DRD4 L vs. DRD4S) moderated the relationship between sexual trauma and STBs in a sample of psychiatrically hospitalized adolescents. A total of 76 psychiatrically hospitalized adolescents provided saliva samples for genotyping procedures and completed assessment measures...
June 7, 2016: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/27217152/attention-deficit-hyperactivity-disorder-in-adults-a-systematic-review-and-meta-analysis-of-genetic-pharmacogenetic-and-biochemical-studies
#12
REVIEW
C Bonvicini, S V Faraone, C Scassellati
The adult form of attention-deficit/hyperactivity disorder has a prevalence of up to 5% and is the most severe long-term outcome of this common disorder. Family studies in clinical samples as well as twin studies suggest a familial liability and consequently different genes were investigated in association studies. Pharmacotherapy with methylphenidate (MPH) seems to be the first-line treatment of choice in adults with attention-deficit hyperactive disorder (ADHD) and some studies were conducted on the genes influencing the response to this drug...
July 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27148829/time-to-wake-up-no-impact-of-comt-val158met-gene-variation-on-circadian-preferences-arousal-regulation-and-sleep
#13
Philippe Jawinski, Sophie Tegelkamp, Christian Sander, Madlen Häntzsch, Jue Huang, Nicole Mauche, Markus Scholz, Janek Spada, Christine Ulke, Ralph Burkhardt, Andreas Reif, Ulrich Hegerl, Tilman Hensch
Dopamine has been implicated in the regulation of sleep-wake states and the circadian rhythm. However, there is no consensus on the impact of two established dopaminergic gene variants: the catechol-O-methyltransferase Val158Met (COMT Val158Met; rs4680) and the dopamine D4 receptor Exon III variable-number-of-tandem-repeat polymorphism (DRD4 VNTR). Pursuing a multi-method approach, we examined their potential effects on circadian preferences, arousal regulation and sleep. Subjects underwent a 7-day actigraphy assessment (SenseWear Pro3), a 20-minute resting EEG (analyzed using VIGALL 2...
2016: Chronobiology International
https://www.readbyqxmd.com/read/27115024/data-describing-the-effect-of-drd4-promoter-polymorphisms-on-promoter-activity
#14
Shoin Tei, Hiroaki Mitsuhashi, Shoichi Ishiura
This data article tested whether polymorphisms within the dopamine D4 receptor (DRD4) gene promoter can lead to differences in the promoter activity. The variants, a 120-bp variable number tandem repeat (VNTR), -906 T/C, -809 G/A, -616G/C, and -521C/T, were introduced into the DRD4 promoter and the promoter activity was measured in a neural cell line using the luciferase assay. However, no differences were detected among the haplotypes investigated, and the in vitro data obtained from our protocol could not support the involvement of DRD4 promoter polymorphisms in heritable human traits...
June 2016: Data in Brief
https://www.readbyqxmd.com/read/26845260/temperament-and-externalizing-behavior-as-mediators-of-genetic-risk-on-adolescent-substance-use
#15
Elisa M Trucco, Brian M Hicks, Sandra Villafuerte, Joel T Nigg, Margit Burmeister, Robert A Zucker
Understanding how specific genes contribute to risk for addiction remains challenging. This study tests whether childhood temperament and externalizing behavior in early adolescence account for a portion of the association between specific genetic variants and substance use problems in late adolescence. The sample consisted of 487 adolescents from the Michigan Longitudinal Study, a high-risk sample (70.2% male, 81.7% European American ancestry). Polymorphisms across serotonergic (SLC6A4, 5-HTTLPR), dopaminergic (DRD4, u-VNTR), noradrenergic (SLC6A2, rs36021), and GABAergic (GABRA2, rs279858; GABRA6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems...
2016: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/26688118/dopamine-d4-receptor-vntr-polymorphism-associated-with-greater-risk-for-substance-abuse-among-adolescents-with-disruptive-behavior-disorders-preliminary-results
#16
Travis T Mallard, James Doorley, Christianne L Esposito-Smythers, John E McGeary
BACKGROUND AND OBJECTIVES: The variable number tandem repeats (VNTR) polymorphism of the dopamine D4 receptor gene (DRD4) has received considerable attention as a potential genetic contributor to addiction. However, is unclear whether the polymorphism is involved in developing general traits that lead to risky behavior or an intermediate phenotype more specific to substance use disorders. Association studies have produced equivocal results. To control for potential confounds, the present study examined whether the long variant of the DRD4 VNTR polymorphism (DRD4L) is associated with greater substance misuse in a homogenous clinical sample of youth with a disruptive behavior disorder (DBD)...
January 2016: American Journal on Addictions
https://www.readbyqxmd.com/read/26581567/self-reported-sexual-behavioral-interests-and-polymorphisms-in-the-dopamine-receptor-d4-drd4-exon-iii-vntr-in-heterosexual-young-adults
#17
Andrew C Halley, Melanie Boretsky, David A Puts, Mark Shriver
Polymorphisms in the dopamine D4 receptor (DRD4) have previously been shown to associate with a variety of human behavioral phenotypes, including ADHD pathology, alcohol and tobacco craving, financial risk-taking in males, and broader personality traits such as novelty seeking. Recent research has linked the presence of a 7-repeat (7R) allele in a 48-bp variable number of tandem repeats (VNTR) along exon III of DRD4 to age at first sexual intercourse, sexual desire, arousal and function, and infidelity and promiscuity...
November 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/26471374/genetic-contributions-to-attentional-response-time-slopes-across-repeated-trials
#18
Rebecca A Lundwall, James L Dannemiller
BACKGROUND: Attention provides vital contribution to everyday functioning, and deficits in attention feature in many psychological disorders. Improved understanding of attention may eventually be critical to early identification and treatment of attentional deficits. One step in that direction is to acquire a better understanding of genetic associations with performance on a task measuring reflexive (exogenous) visual attention. Reflexive attention is an important component of overall attention because (along with voluntary selective attention) it participates in determining where attention is allocated and how susceptible to distractors the subject might be...
2015: BMC Neuroscience
https://www.readbyqxmd.com/read/26449981/parental-smoke-exposure-and-the-development-of-nicotine-craving-in-adolescent-novice-smokers-the-roles-of-drd2-drd4-and-oprm1-genotypes
#19
Marloes Kleinjan, Rutger C M E Engels, Joseph R DiFranza
BACKGROUND: Among adolescent novice smokers, craving is often the first, and is the most reported, symptom of nicotine dependence. Until now, little has been known about the development of craving symptoms in novice smokers. The aim of this study was to identify specific genetic (i.e., DRD2 Taq1A, DRD4 48 bp VNTR, and OPRM1 A118G polymorphisms) and environmental mechanisms that underlie the emergence of both cue-induced and cognitive craving among adolescent novice smokers. METHOD: A five-wave longitudinal, genetically-informed survey study was conducted with intervals of four months...
2015: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/26441510/dopamine-d4-receptor-gene-and-religious-affiliation-correlate-with-dictator-game-altruism-in-males-and-not-females-evidence-for-gender-sensitive-gene-%C3%A3-culture-interaction
#20
Yushi Jiang, Rachel Bachner-Melman, Soo Hong Chew, Richard P Ebstein
On a large sample of 2288 Han Chinese undergraduates, we investigated how religion and DRD4 are related to human altruistic giving behavior as measured with the Andreoni-Miller Dictator Game. This game enables us to clearly specify (non-)selfishness, efficiency, and fairness motives for sharing. Participants were further classified into religious categories (Christian, Buddhist-Tao, and No Religion) based on self-reports, and genotyped for the dopamine D4 receptor (DRD4) gene exon III VNTR. Our analysis revealed a significant interaction between religion and DRD4 correlated with giving behavior solely among males: Whereas no significant association between religion and sharing decisions was observed in the majority 4R/4R genotype group, a significant difference in giving behavior between Christian and non-Christian males was seen in the non-4R/4R group, with Christian men being overall more altruistic (less selfish and fairer) than non-Christian men...
2015: Frontiers in Neuroscience
keyword
keyword
78324
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"