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Gene-environment interaction

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https://www.readbyqxmd.com/read/28916278/microbial-reduction-of-vanadium-v-in-groundwater-interactions-with-coexisting-common-electron-acceptors-and-analysis-of-microbial-community
#1
Hui Liu, Baogang Zhang, Heyang Yuan, Yutong Cheng, Song Wang, Zhen He
Vanadium (V) pollution in groundwater has posed serious risks to the environment and public health. Anaerobic microbial reduction can achieve efficient and cost-effective remediation of V(V) pollution, but its interactions with coexisting common electron acceptors such as NO3(-), Fe(3+), SO4(2-) and CO2 in groundwater remain unknown. In this study, the interactions between V(V) reduction and reduction of common electron acceptors were examined with revealing relevant microbial community and identifying dominant species...
September 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28914236/the-kr%C3%A3-mmel-germany-childhood-leukaemia-cluster-a-review-and-update
#2
Bernd Grosche, Peter Kaatsch, Birger G J Heinzow, Heinz-Erich Wichmann
The debate surrounding possible adverse health effects from the civil use of nuclear power under normal operating conditions has been on-going since its introduction. It was particularly intensified by the detection of three leukaemia clusters near nuclear installations, i.e. near the reprocessing plants in Sellafield and Dounreay, UK, and near the Krümmel nuclear power plant, Germany, the last of which commenced between 1990 and 1991 and was first described in 1992; it continued until 2003, and an elevated risk up to 2005 has been reported in the literature...
September 15, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28913343/exacerbating-and-reversing-lysosomal-storage-diseases-from-yeast-to-humans
#3
REVIEW
Tamayanthi Rajakumar, Andrew B Munkacsi, Stephen L Sturley
Lysosomal storage diseases (LSDs) arise from monogenic deficiencies in lysosomal proteins and pathways and are characterized by a tissue-wide accumulation of a vast variety of macromolecules, normally specific to each genetic lesion. Strategies for treatment of LSDs commonly depend on reduction of the offending metabolite(s) by substrate depletion or enzyme replacement. However, at least 44 of the ~50 LSDs are currently recalcitrant to intervention. Murine models have provided significant insights into our understanding of many LSD mechanisms; however, these systems do not readily permit phenotypic screening of compound libraries, or the establishment of genetic or gene-environment interaction networks...
August 25, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28910727/gene-environment-interaction-does-fluoride-influence-the-reproductive-hormones-in-male-farmers-modified-by-er%C3%AE-gene-polymorphisms
#4
Qiang Ma, Hui Huang, Long Sun, Tong Zhou, Jingyuan Zhu, Xuemin Cheng, Lijv Duan, Zhiyuan Li, Liuxin Cui, Yue Ba
The occurrence of endemic fluorosis is derived from high fluoride levels in drinking water and industrial fumes or dust. Reproductive disruption is also a major harm caused by fluoride exposure besides dental and skeletal lesions. However, few studies focus on the mechanism of fluoride exposure on male reproductive function, especially the possible interaction of fluoride exposure and gene polymorphism on male reproductive hormones. Therefore, we conducted a cross-sectional study in rural areas of Henan province in China to explore the interaction between the estrogen receptor alpha (ERα) gene and fluoride exposure on reproductive hormone levels in male farmers living in the endemic fluorosis villages...
September 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28904253/genetic-variants-of-ramp2-and-clr-are-associated-with-stroke
#5
Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Wakiko Takeshita, Komei Iwai, Yoshiyuki Watanabe, Masahiro Nakatochi, Chisato Shimanoe, Keitaro Tanaka, Isao Oze, Hidemi Ito, Hirokazu Uemura, Sakurako Katsuura-Kamano, Rie Ibusuki, Ippei Shimoshikiryo, Naoyuki Takashima, Aya Kadota, Sayo Kawai, Tae Sasakabe, Rieko Okada, Asahi Hishida, Mariko Naito, Kiyonori Kuriki, Kaori Endoh, Norihiro Furusyo, Hiroaki Ikezaki, Sadao Suzuki, Akihiro Hosono, Haruo Mikami, Yohko Nakamura, Michiaki Kubo, Kenji Wakai
AIM: Stroke is associated closely with vascular homeostasis, and several complex processes and interacting pathways, which involve various genetic and environmental factors, contribute to the risk of stroke. Although adrenomedullin (ADM) has a number of physiological and vasoprotective functions, there are few studies of the ADM receptor system in humans. The ADM receptor comprises a calcitonin-receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMPs). We analyzed single nucleotide polymorphisms (SNPs) in the RAMP2 and CLR genes to determine their association with stroke in the light of gene-environment interactions...
September 14, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28903384/a-novel-sharpin-prmt5-h3r2me1-axis-is-essential-for-lung-cancer-cell-invasion
#6
Tingxiong Fu, Xiuwei Lv, Qingzhi Kong, Changjing Yuan
SHARPIN (Shank-associated RH domain interacting protein) is the main component of the linear ubiquitin chain activation complex (LUBAC). SHARPIN is involved in regulating inflammation and cancer progression. However, whether SHARPIN plays an important role in lung cancer metastasis and the potential underlying mechanism are still unknown. Here, for the first time, we reported that SHARPIN expression is closely related to lung cancer progression. Moreover, SHARPIN plays a central role in controlling lung cancer cell metastasis...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902892/neanderthal-and-denisova-tooth-protein-variants-in-present-day-humans
#7
Clément Zanolli, Mathilde Hourset, Rémi Esclassan, Catherine Mollereau
Environment parameters, diet and genetic factors interact to shape tooth morphostructure. In the human lineage, archaic and modern hominins show differences in dental traits, including enamel thickness, but variability also exists among living populations. Several polymorphisms, in particular in the non-collagenous extracellular matrix proteins of the tooth hard tissues, like enamelin, are involved in dental structure variation and defects and may be associated with dental disorders or susceptibility to caries...
2017: PloS One
https://www.readbyqxmd.com/read/28902722/diagnostic-approach-to-ocular-infections-using-various-techniques-from-conventional-culture-to-next-generation-sequencing-analysis
#8
Hiroshi Eguchi, Fumika Hotta, Tomomi Kuwahara, Haruyuki Imaohji, Chika Miyazaki, Miou Hirose, Shunji Kusaka, Masahiko Fukuda, Yoshikazu Shimomura
Ocular infection is caused by both endogenous (resident) and exogenous (environmental) microbes. As the ocular surface interacts with both outer environment and its own resident microbiota, clinical ocular samples are predicted to contain a diverse set of microorganisms. Microscopy of sample smears is an important step in the diagnostic process of infectious diseases to interpret the culture results. Traditional culture techniques have several limitations in the detection and/or identification of uncharacterized bacteria of environmental origin...
September 11, 2017: Cornea
https://www.readbyqxmd.com/read/28902619/a-case-control-association-study-of-12-candidate-genes-and-attempted-suicide-in-french-adolescents
#9
Bojan Mirkovic, David Cohen, Claudine Laurent, Malaika Lasfar, Christophe Marguet, Prsicille Gerardin
Background Suicide is the second leading cause of death for 10-19-year-olds. Evidence has shown that attempted suicide is a complex interplay of genes and environmental factors. In the adult population, possible associations between genetic polymorphisms and suicidal behaviors have been investigated for several genes, most often with inconsistent findings and poor replicability of significant associations. This study aimed to identify gene variants conferring risk for adolescent suicide attempt. Methods We selected the genes and variants after an analysis of the literature and a selection of the most significant associations identified...
September 13, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28902451/ectopic-expression-of-glycosyltransferase-ugt76e11-increases-flavonoid-accumulation-and-enhances-abiotic-stress-tolerance-in-arabidopsis
#10
Qin Li, Hui-Min Yu, Xia-Fei Meng, Ji-Shan Lin, Yan-Jie Li, Bing-Kai Hou
Although plant glycosyltransferases are thought to play important roles in growth and interaction with environments, little is known about their physiological roles for the most members of plant glycosyltransferase family. We cloned and characterized an Arabidopsis glycosyltransferase gene UGT76E11. Its in vivo physiological effects in flavonoid accumulation and plant tolerance to abiotic stresses were investigated. UGT76E11 gene was up-regulated in transcription expression under various stress conditions including salinity, drought and H2 O2 treatment...
September 13, 2017: Plant Biology
https://www.readbyqxmd.com/read/28900609/genes-contributing-to-porphyromonas-gingivalis-fitness-in-abscess-and-epithelial-cell-colonization-environments
#11
Daniel P Miller, Justin A Hutcherson, Yan Wang, Zuzanna M Nowakowska, Jan Potempa, Deborah R Yoder-Himes, David A Scott, Marvin Whiteley, Richard J Lamont
Porphyromonas gingivalis is an important cause of serious periodontal diseases, and is emerging as a pathogen in several systemic conditions including some forms of cancer. Initial colonization by P. gingivalis involves interaction with gingival epithelial cells, and the organism can also access host tissues and spread haematogenously. To better understand the mechanisms underlying these properties, we utilized a highly saturated transposon insertion library of P. gingivalis, and assessed the fitness of mutants during epithelial cell colonization and survival in a murine abscess model by high-throughput sequencing (Tn-Seq)...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28900103/yeej-is-an-inverse-autotransporter-from-escherichia-coli-that-binds-to-peptidoglycan-and-promotes-biofilm-formation
#12
Marta Martinez-Gil, Kelvin G K Goh, Elze Rackaityte, Chizuko Sakamoto, Bianca Audrain, Danilo G Moriel, Makrina Totsika, Jean-Marc Ghigo, Mark A Schembri, Christophe Beloin
Escherichia coli is a commensal or pathogenic bacterium that can survive in diverse environments. Adhesion to surfaces is essential for E. coli colonization, and thus it is important to understand the molecular mechanisms that promote this process in different niches. Autotransporter proteins are a class of cell-surface factor used by E. coli for adherence. Here we characterized the regulation and function of YeeJ, a poorly studied but widespread representative from an emerging class of autotransporter proteins, the inverse autotransporters (IAT)...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899534/gene-by-environment-interactions-of-the-clock-pemt-and-ghrelin%C3%A2-loci-with-average-sleep-duration-in-relation-to-obesity-traits%C3%A2-using-a-cohort-of-643-new-zealand-european-children
#13
Mohanraj Krishnan, Andrew N Shelling, Clare R Wall, Edwin A Mitchell, Rinki Murphy, Lesley M E McCowan, John M D Thompson
OBJECTIVES: Modern technology may have desensitised the 'biological clock' to environmental cues, disrupting the appropriate co-ordination of metabolic processes. Susceptibility to misalignment of circadian rhythms may be partly genetically influenced and effects on sleep quality and duration could predispose to poorer health outcomes. Shorter sleep duration is associated with obesity traits, which are brought on by an increased opportunity to eat and/or a shift of hormonal profile promoting hunger...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28898269/faecal-carriage-of-ctx-m-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-among-street-children-dwelling-in-mwanza-city-tanzania
#14
Nyambura Moremi, Heike Claus, Ulrich Vogel, Stephen E Mshana
BACKGROUND: Data on ESBL carriage of healthy people including children are scarce especially in developing countries. We analyzed the prevalence and genotypes of ESBL-producing Enterobacteriaceae (EPE) in Tanzanian street children with rare contact to healthcare facilities but significant interactions with the environment, animals and other people. METHODOLOGY/ PRINCIPLE FINDINGS: Between April and July 2015, stool samples of 107 street children, who live in urban Mwanza were analyzed for EPE...
2017: PloS One
https://www.readbyqxmd.com/read/28898263/genome-wide-analysis-of-parent-of-origin-interaction-effects-with-environmental-exposure-pooxe-an-application-to-european-and-asian-cleft-palate-trios
#15
Øystein A Haaland, Astanand Jugessur, Miriam Gjerdevik, Julia Romanowska, Min Shi, Terri H Beaty, Mary L Marazita, Jeffrey C Murray, Allen J Wilcox, Rolv T Lie, Håkon K Gjessing
Cleft palate only is a common birth defect with high heritability. Only a small fraction of this heritability is explained by the genetic variants identified so far, underscoring the need to investigate other disease mechanisms, such as gene-environment (GxE) interactions and parent-of-origin (PoO) effects. Furthermore, PoO effects may vary across exposure levels (PoOxE effects). Such variation is the focus of this study. We upgraded the R-package Haplin to enable direct tests of PoOxE effects at the genome-wide level...
2017: PloS One
https://www.readbyqxmd.com/read/28895594/determination-of-spectral-markers-of-cytotoxicity-and-genotoxicity-using-in-vitro-raman-microspectroscopy-cellular-responses-to-polyamidoamine-dendrimer-exposure
#16
Esen Efeoglu, Alan Casey, Hugh J Byrne
Although consumer exposure to nanomaterials is ever increasing, with potential increased applications in areas such as drug and/or gene delivery, contrast agents and diagnosis, the determination of the cyto- and geno-toxic effects of nanomaterials on human health and the environment still remains challenging. Although many techniques have been established and adapted to determine the cytotoxicity and genotoxicity of nano-sized materials, these techniques remain limited by the number of assays required, total cost, and use of labels and they struggle to explain the underlying interaction mechanisms...
September 12, 2017: Analyst
https://www.readbyqxmd.com/read/28893852/root-architecture-shaping-by-the-environment-is-orchestrated-by-dynamic-gene-expression-in-space-and-time
#17
Liam Walker, Clare Boddington, Dafyd Jenkins, Ying Wang, Jesper T Grønlund, Jo Hulsmans, Sanjeev Kumar, Dhaval Patel, Jonathan D Moore, Anthony Carter, Siva Samavedam, Giovanni Bomono, David S Hersh, Gloria M Coruzzi, Nigel J Burroughs, Miriam L Gifford
Shaping of root architecture is a quintessential developmental response that involves the concerted action of many different cell types, is highly dynamic and underpins root plasticity. To determine to what extent the environmental regulation of lateral root development is a product of cell type preferential activities, we tracked transcriptomic responses to two different treatments that both change root development in Arabidopsis thaliana, at an unprecedented level of temporal detail. We found that individual transcripts are expressed with a very high degree of temporal and spatial specificity, yet biological processes are commonly regulated, in a mechanism we term response non-redundancy...
September 11, 2017: Plant Cell
https://www.readbyqxmd.com/read/28893308/more-than-2500%C3%A2-years-of-oil-exposure-shape-sediment-microbiomes-with-the-potential-for-syntrophic-degradation-of-hydrocarbons-linked-to-methanogenesis
#18
Antonios Michas, Gisle Vestergaard, Kathleen Trautwein, Pavlos Avramidis, Dimitris G Hatzinikolaou, Constantinos E Vorgias, Heinz Wilkes, Ralf Rabus, Michael Schloter, Anne Schöler
BACKGROUND: Natural oil seeps offer the opportunity to study the adaptation of ecosystems and the associated microbiota to long-term oil exposure. In the current study, we investigated a land-to-sea transition ecosystem called "Keri Lake" in Zakynthos Island, Greece. This ecosystem is unique due to asphalt oil springs found at several sites, a phenomenon already reported 2500 years ago. Sediment microbiomes at Keri Lake were studied, and their structure and functional potential were compared to other ecosystems with oil exposure histories of various time periods...
September 11, 2017: Microbiome
https://www.readbyqxmd.com/read/28891785/attachment-style-moderates-effects-of-fkbp5-polymorphisms-and-childhood-abuse-on-posttraumatic-stress-symptoms-results-from-the-national-health-and-resilience-in-veterans-study
#19
Amanda J F Tamman, Lauren M Sippel, Shizhong Han, Yuval Neria, John H Krystal, Steven M Southwick, Joel Gelernter, Robert H Pietrzak
OBJECTIVES: To determine the main and interactive effects of four FKBP5 polymorphisms (rs9296158, rs3800373, rs1360780, and rs9470080), childhood abuse, and attachment style in predicting severity of PTSD symptoms in two independent, nationally representative samples of U.S. military veterans. METHODS: Data were analyzed from two independent samples of European American (EA) U.S. military veterans who participated in the National Health and Resilience in Veterans Study (N = 1,585 and 577 respectively)...
September 11, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28891741/erna-binding-produces-tailored-cbp-activity-profiles-to-regulate-gene-expression
#20
Daniel A Bose, Shelley L Berger
Enhancers are cis- regulatory genetic elements crucial for controlling temporal and cell-type specific patterns of gene expression. Active enhancers generate bi-directional non-coding RNA transcripts called enhancer RNAs (eRNAs). eRNAs are important for stimulating gene expression, but precise mechanisms for this ability remain unclear. Here we highlight recent findings that demonstrate a direct interaction between RNAs and the transcriptional co-activator Creb-binding protein (CBP). Notably, RNA binding could stimulate the core histone acetyltransferase activity of the enzyme, observable in cells as a link between eRNA production, CBP-dependent histone acetylation and expression of genes regulated by specific enhancers...
September 11, 2017: RNA Biology
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