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https://www.readbyqxmd.com/read/29437140/survival-analysis-and-associated-factors-in-thai-patients-on-peritoneal-dialysis-under-the-pd-first-policy
#1
Siribha Changsirikulchai, Suwannee Sriprach, Nintita S Thokanit, Jirayut Janma, Piyatida Chuengsaman, Dhavee Sirivongs
BACKGROUND: The peritoneal dialysis First (PD First) policy means that PD is the first modality of dialysis chosen for patients with end-stage renal disease (ESRD), as put forth by the Universal Health Coverage (UHC) scheme. It was initiated in Thailand in 2008. Our aim is to analyze patient survival, technique survival, and associated factors. METHODS: Data of PD patients from January 2008 to November 2016 were studied. We calculated patient and technique survival rates (censored for death and kidney transplantation)...
February 7, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29430739/racial-disparities-in-kidney-transplant-waitlist-appearance-in-chicago-is-it-race-or-place
#2
Robert B Peng, Haena Lee, Zheng T Ke, Milda R Saunders
BACKGROUND: Prior work has demonstrated how neighborhood poverty and racial composition impact racial disparities in access to the deceased donor kidney transplant waitlist, both nationally and regionally. We examined the association between neighborhood characteristics and racial disparities in time to transplant waitlist in Chicago, a diverse city with continued neighborhood segregation. METHODS: Using data from the United States Renal Data System (USRDS) and the US Census, we investigated time from dialysis initiation to kidney transplant waitlisting for African American and white patients in Chicago using cause-specific proportional hazards analyses, adjusting for individual sociodemographic and clinical characteristics, as well as neighborhood poverty and racial composition...
February 11, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29429751/pulmonary-hypertension-mortality-and-cardiovascular-disease-in-ckd-and-esrd-patients-a-systematic-review-and-meta-analysis
#3
Mengyao Tang, Jonathan A Batty, Chiayu Lin, Xiaohong Fan, Kevin E Chan, Sahir Kalim
BACKGROUND: Pulmonary hypertension is common in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) and may be associated with poor outcomes. The magnitude of the association between pulmonary hypertension and mortality is uncertain due to the small size and variable findings of observational studies. STUDY DESIGN: Systematic review and meta-analysis of observational studies using subgroup analyses and metaregression. SETTING & POPULATION: Patients with ESRD or earlier stages of CKD...
February 8, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29423210/the-european-renal-association-european-dialysis-and-transplant-association-era-edta-registry-annual-report-2015-a-summary
#4
Anneke Kramer, Maria Pippias, Marlies Noordzij, Vianda S Stel, Nikolaos Afentakis, Patrice M Ambühl, Anton M Andrusev, Emma Arcos Fuster, Federico E Arribas Monzón, Anders Åsberg, Myftar Barbullushi, Marjolein Bonthuis, Fergus J Caskey, Pablo Castro de la Nuez, Harijs Cernevskis, Jean-Marin des Grottes, Liliana Garneata, Eliezer Golan, Marc H Hemmelder, Kyriakos Ioannou, Faical Jarraya, Mykola Kolesnyk, Kirill Komissarov, Mathilde Lassalle, Fernando Macario, Beatriz Mahillo-Duran, Angel L Martín de Francisco, Runolfur Palsson, Ülle Pechter, Halima Resic, Boleslaw Rutkowski, Carmen Santiuste de Pablos, Nurhan Seyahi, Sanja Simic Ogrizovic, María F Slon Roblero, Viera Spustova, Olivera Stojceva-Taneva, Jamie Traynor, Ziad A Massy, Kitty J Jager
Background: This article summarizes the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry's 2015 Annual Report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2015 within 36 countries. Methods: In 2016 and 2017, the ERA-EDTA Registry received data on patients who were undergoing RRT for ESRD in 2015, from 52 national or regional renal registries. Thirty-two registries provided individual patient-level data and 20 provided aggregated-level data...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29416201/study-of-echocardiographic-changes-after-kidney-transplantation-in-end-stage-renal-disease-patients
#5
Hamidreza Omrani, Alireza Rai, Zahra Daraei, Masoud Sadeghi
Background: Cardiovascular complications are the leading cause of mortality in end-stage renal disease (ESRD) patients. This study aimed to evaluate the efficacy of kidney transplantation on the cardiovascular status in ESRD patients. Methods: During 2012 to 2014 and in a cross-sectional study, 181 patients were randomly selected for this study. All patients were followed for periods of 6 and 12 months after kidney transplantation. The patients with ESRD and kidney transplant recipients; the patients with left ventricle ejection fraction<50%, left ventricular hypertrophy, mitral valve regurgitation and tricuspid valve regurgitation were included to study and the patients with kidney transplant rejection, myocardial infarction, high blood pressure with treatment-resistant, high blood pressure and addicted patients were censored...
December 2017: Medical Archives
https://www.readbyqxmd.com/read/29407310/liver-transplant-recipients-with-end-stage-renal-disease-largely-benefit-from-kidney-transplantation
#6
T Yunhua, Z Qiang, J Lipeng, H Shanzhou, Z Zebin, J Fei, Z Zhiheng, W Linhe, J Weiqiang, W Dongping, G Zhiyong, H Xiaoshun
BACKGROUND: The incidence of end-stage renal disease (ESRD) after liver transplant (LT) has increased. The actual benefit of kidney transplantation (KT) is not completely understood in LT recipients with ESRD. METHODS: We analyzed Scientific Registry of Transplant Recipients data for all KT candidates with prior LT from 1998 to 2014; the benefits of KT relative to remaining on dialysis were compared by means of multivariate Cox proportional hazards regression analysis...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29402819/clinical-heterogeneity-in-familial-iga-nephropathy
#7
Neil K Fennelly, Claire Kennedy, Allan C Jenkinson, Dervla M Connaughton, Caragh Stapleton, Anthony M Dorman, Brendan Doyle, Peter J Conlon
BACKGROUND: IgA nephropathy is the most common primary glomerulonephritis worldwide and a significant cause of end-stage renal disease (ESRD). While most cases of IgA nephropathy are considered sporadic, familial cases have been reported. METHODS: We performed a national audit of 1,809 patients attending renal clinics and dialysis units to identify a family history among patients with kidney disease. We reviewed all renal biopsies performed at our institution spanning a 30-year period...
January 19, 2018: Nephron
https://www.readbyqxmd.com/read/29402767/bardoxolone-methyl-improves-kidney-function-in-patients-with-chronic-kidney-disease-stage-4-and-type-2-diabetes-post-hoc-analyses-from-bardoxolone-methyl-evaluation-in-patients-with-chronic-kidney-disease-and-type-2-diabetes-study
#8
Melanie P Chin, George L Bakris, Geoffrey A Block, Glenn M Chertow, Angie Goldsberry, Lesley A Inker, Hiddo J L Heerspink, Megan O'Grady, Pablo E Pergola, Christoph Wanner, David G Warnock, Colin J Meyer
BACKGROUND: Increases in measured inulin clearance, measured creatinine clearance, and estimated glomerular filtration rate (eGFR) have been observed with bardoxolone methyl in 7 studies enrolling approximately 2,600 patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The largest of these studies was Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes (BEACON), a multinational, randomized, double-blind, placebo-controlled phase 3 trial which enrolled patients with T2D and CKD stage 4...
January 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29371341/standardized-transplantation-referral-ratio-to-assess-performance-of-transplant-referral-among-dialysis-facilities
#9
Sudeshna Paul, Laura C Plantinga, Stephen O Pastan, Jennifer C Gander, Sumit Mohan, Rachel E Patzer
BACKGROUND AND OBJECTIVES: For patients with ESRD, referral from a dialysis facility to a transplant center for evaluation is an important step toward kidney transplantation. However, a standardized measure for assessing clinical performance of dialysis facilities transplant access is lacking. We describe methodology for a new dialysis facility measure: the Standardized Transplantation Referral Ratio. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Transplant referral data from 8308 patients with incident ESRD within 249 dialysis facilities in the United States state of Georgia were linked with US Renal Data System data from January of 2008 to December of 2011, with follow-up through December of 2012...
January 25, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29338859/renal-function-and-outcome-after-heart-transplantation
#10
Oscar Kolsrud, Kristjan Karason, Erik Holmberg, Sven-Erik Ricksten, Marie Felldin, Ola Samuelsson, Göran Dellgren
OBJECTIVES: To investigate whether measured glomerular filtration rate (mGFR) is a risk factor for death and/or end-stage renal disease (ESRD) after heart transplantation (HTx). METHODS: All adult patients (n = 416) who underwent HTx between 1988 and 2010 were included. mGFR was performed both preoperatively and postoperatively as annual follow-up. Eight patients received a concomitant kidney transplant (KTx), and 15 underwent late KTx due to chronic renal failure after HTx...
December 14, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29334900/process-evaluation-of-the-radiant-community-study-a-dialysis-facility-level-intervention-to-increase-referral-for-kidney-transplantation
#11
Reem E Hamoda, Jennifer C Gander, Laura J McPherson, Kimberly J Arriola, Loren Cobb, Stephen O Pastan, Laura Plantinga, Teri Browne, Erica Hartmann, Laura Mulloy, Carlos Zayas, Jenna Krisher, Rachel E Patzer
BACKGROUND: The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiveness of a 1-year multicomponent education and quality improvement intervention in increasing referral for kidney transplant evaluation among selected Georgia dialysis facilities. METHODS: To assess implementation of the RaDIANT intervention, we conducted a process evaluation at the conclusion of the intervention period (January-December 2014)...
January 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29314264/a-practical-guide-for-the-care-of-patients-with-end-stage-renal-disease-near-the-end-of-life
#12
Amar D Bansal, Jane O Schell
Most patients who rely on dialysis for treatment of end-stage renal disease (ESRD) never receive a kidney transplant. Therefore, it is important for nephrology providers to feel comfortable discussing the role of dialysis near the end of life (EOL). Advance care planning (ACP) is an ongoing process of learning patient values and goals in an effort to outline preferences for current and future care. This review presents a framework for how to incorporate ACP in the care of dialysis patients throughout the kidney disease course and at the EOL...
January 3, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29277956/kidney-transplantation-and-waitlist-mortality-rates-among-candidates-registered-as-willing-to-accept-a-hepatitis-c-infected-kidney
#13
Brittany A Shelton, Deirdre Sawinski, Shikha Mehta, Rhiannon D Reed, Paul A MacLennan, Jayme E Locke
BACKGROUND: HCV-infected (HCV+) ESRD patients derive significant survival benefit from kidney transplantation (KT) over remaining on dialysis. Given high mortality rates on dialysis and the unique ability to accept HCV+ and HCV- donor kidneys, understanding their access to KT is essential. METHODS: 3,963 adult kidney-only candidates reported as willing to accept an HCV+ kidney from 2008-2014 were identified and assumed to be HCV+. Time-at-risk began at date of listing...
December 26, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29242373/changes-in-excess-mortality-from-end-stage-renal-disease-in-the-united-states-from-1995-to-2013
#14
Bethany J Foster, Mark M Mitsnefes, Mourad Dahhou, Xun Zhang, Benjamin L Laskin
BACKGROUND AND OBJECTIVES: Individuals with ESRD have a very high risk of death. Although mortality rates have decreased over time in ESRD, it is unknown if improvements merely reflect parallel increases in general population survival. We, therefore, examined changes in the excess risk of all-cause mortality-over and above the risk in the general population-among people treated for ESRD in the United States from 1995 to 2013. We hypothesized that the magnitude of change in the excess risk of death would differ by age and RRT modality...
January 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29228920/comparison-of-outcomes-between-emergent-start-and-planned-start-peritoneal-dialysis-in-incident-esrd-patients-a-prospective-observational-study
#15
Wen-Yi Li, Yi-Cheng Wang, Shang-Jyh Hwang, Shih-Hua Lin, Kwan-Dun Wu, Yung-Ming Chen
BACKGROUND: The clinical consequences of starting chronic peritoneal dialysis (PD) after emergent dialysis via a temporary hemodialysis (HD) catheter has rarely been evaluated within a full spectrum of treated end-stage renal disease (ESRD). We investigated the longer-term outcomes of patients undergoing emergent-start PD in comparison with that of other practices of PD or HD in a prospective cohort of new-onset ESRD. METHODS: This was a 2-year prospective observational study...
December 11, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29225970/dialysis-provision-and-implications-of-health-economics-on-peritoneal-dialysis-utilization-a-review-from-a-malaysian-perspective
#16
REVIEW
Mohd Rizal Abdul Manaf, Naren Kumar Surendra, Abdul Halim Abdul Gafor, Lai Seong Hooi, Sunita Bavanandan
End-stage renal disease (ESRD) is managed by either lifesaving hemodialysis (HD) and peritoneal dialysis (PD) or a kidney transplant. In Malaysia, the prevalence of dialysis-treated ESRD patients has shown an exponential growth from 504 per million population (pmp) in 2005 to 1155 pmp in 2014. There were 1046 pmp patients on HD and 109 pmp patients on PD in 2014. Kidney transplants are limited due to lack of donors. Malaysia adopts public-private financing model for dialysis. Majority of HD patients were treated in the private sector but almost all PD patients were treated in government facilities...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/29224373/pharmacotherapy-and-treatment-options-for-hiv-associated-nephropathy
#17
Steven Menez, Mohamad Hanouneh, Blaithin A McMahon, Derek M Fine, Mohamed G Atta
Human immunodeficiency virus (HIV) remains a worldwide disease with significant mortality and morbidity. There are a multitude of HIV-related kidney diseases including HIV-associated nephropathy (HIVAN) most prominently. The risk of developing HIVAN increases with decreasing CD4 count, higher viral load, and based on genetic factors. The mortality rate for those with HIVAN-end stage renal disease (ESRD) remains 2.5-3 times higher than ESRD patients without HIVAN. Areas covered: The epidemiology of HIVAN, particularly risk assessment, will be explored in this review...
January 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29187194/treatment-effects-of-renin-angiotensin-aldosterone-system-blockade-on-kidney-failure-and-mortality-in-chronic-kidney-disease-patients
#18
Phisitt Vejakama, Atiporn Ingsathit, Gareth J McKay, Alexander P Maxwell, Mark McEvoy, John Attia, Ammarin Thakkinstian
BACKGROUND: Chronic kidney disease (CKD) is a leading cause of death before and after onset of end-stage renal disease (ESRD). Knowing treatments that can delay disease progression will lead to reduced mortality. We therefore aimed to estimate the effectiveness of renin angiotensin aldosterone system (RAAS) blockade on CKD progression. METHODS: We conducted a retrospective CKD cohort at Ubon Ratchathani province, Thailand from 1997 to 2011. ESRD was defined as estimated glomerular filtration rate (eGFR) <15 ml/min/1...
November 29, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29163492/t-cell-composition-of-the-lymph-node-is-associated-with-the-risk-for-early-rejection-after-renal-transplantation
#19
Burç Dedeoglu, Nicolle H R Litjens, Annelies E de Weerd, Frank Jmf Dor, Mariska Klepper, Derek Reijerkerk, Carla C Baan, Michiel G H Betjes
Background: The T-cell composition within the lymph node (LN) of end-stage renal disease (ESRD) patients differs from the composition within the circulation. Activation of the alloreactive T-cell response within secondary lymphoid organs is important after organ transplantation. However, to date no data are present on LN T-cell subsets and the risk for acute rejection after kidney transplantation. Methods: T cells from LNs of ESRD patients were analyzed for frequency of recent thymic emigrants, relative telomere length, expression of differentiation markers, and were related to the development of early acute rejection (EAR), occurring within 3 months after renal transplantation (RT)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29162680/peritoneal-dialysis-in-orthotopic-liver-transplantation-recipients
#20
Nalinee Saiprasertkit, Camila H Nihei, Joanne M Bargman
BACKGROUND: In many dialysis programs, there is resistance to initiating peritoneal dialysis (PD) in liver transplant patients needing renal replacement therapy. This retrospective study reviews the outcome of PD in liver transplant patients at a major transplantation and dialysis center. METHOD: We performed a retrospective cohort study in patients who underwent liver transplants and received PD between 1991 and 2016. Patient demographics, laboratory parameters, and adverse events were collected from our electronic database...
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
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