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https://www.readbyqxmd.com/read/28735717/real-time-cineangiography-visualization-of-cerebral-aneurysm-rupture-in-an-awake-patient-anatomic-physiological-and-functional-correlates
#1
Tasha L Welch, Waleed Brinjikji, Guiseppe Lanzino, William L Lanier
Intracranial aneurysms are common and, on a population-based perspective, are a major cause of morbidity and mortality as a result of mass effect or rupture. Cerebral angiography is the primary technique used for the diagnosis of cerebral aneurysms, and the imaging data have additional utility for planning medical, endovascular, or surgical treatments. An extremely rare periprocedural complication of cerebral angiography is rupture of the aneurysm, either as a chance phenomenon or as a result of some physiologic change or mechanical effect...
July 20, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28713323/model-of-illusions-and-virtual-reality
#2
REVIEW
Mar Gonzalez-Franco, Jaron Lanier
In Virtual Reality (VR) it is possible to induce illusions in which users report and behave as if they have entered into altered situations and identities. The effect can be robust enough for participants to respond "realistically," meaning behaviors are altered as if subjects had been exposed to the scenarios in reality. The circumstances in which such VR illusions take place were first introduced in the 80's. Since then, rigorous empirical evidence has explored a wide set of illusory experiences in VR. Here, we compile this research and propose a neuroscientific model explaining the underlying perceptual and cognitive mechanisms that enable illusions in VR...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28687523/tdp-43-in-the-spectrum-of-mnd-ftld-pathologies
#3
REVIEW
Lanier Heyburn, Charbel E-H Moussa
The relationship between RNA-binding proteins, particularly TAR DNA binding protein 43 (TDP-43), and neurodegeneration is an important area of research. TDP-43 is involved in so many cellular processes that perturbation of protein homeostasis can lead to countless downstream effects. Understanding what leads to this disease-related protein imbalance and the resulting cellular and molecular effects will help to develop targets for disease intervention, whether it be prevention of protein accumulation, or addressing a secondary effect of protein accumulation...
July 4, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28684217/nkg2d-ligand-expression-in-crohn-s-disease-and-nkg2d-dependent-stimulation-of-cd8-t-cell-migration
#4
Kasper Vadstrup, Elisabeth Douglas Galsgaard, Helle Jensen, Lewis L Lanier, James C Ryan, Shih-Yu Chen, Garry P Nolan, Marianne Kajbæk Vester-Andersen, Julie Steen Pedersen, Jens Gerwien, Teis Jensen, Flemming Bendtsen
Interaction between the activating NKG2D receptor on lymphocytes and its ligands MICA, MICB, and ULBP1-6 modulate T and NK cell activity and may contribute to the pathogenesis of Crohn's disease (CD). NKG2D ligands are generally not expressed on the cell surface of normal, non-stressed cells, but expression of MICA and MICB in CD intestine has been reported. In this exploratory study, we further characterize the expression of NKG2D and its ligands, including the less well-described ULBP4-6, in CD, and test if NKG2D ligand interactions are involved in the migration of activated T cells into the affected mucosal compartments...
July 3, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28680419/novel-synechococcus-genomes-reconstructed-from-freshwater-reservoirs
#5
Pedro J Cabello-Yeves, Jose M Haro-Moreno, Ana-Belen Martin-Cuadrado, Rohit Ghai, Antonio Picazo, Antonio Camacho, Francisco Rodriguez-Valera
Freshwater picocyanobacteria including Synechococcus remain poorly studied at the genomic level, compared to their marine representatives. Here, using a metagenomic assembly approach we discovered two novel Synechococcus sp. genomes from two freshwater reservoirs Tous and Lake Lanier, both sharing 96% average nucleotide identity and displaying high abundance levels in these two lakes located at similar altitudes and temperate latitudes. These new genomes have the smallest estimated size (2.2 Mb) and average intergenic spacer length (20 bp) of any previously sequenced freshwater Synechococcus, which may contribute to their success in oligotrophic freshwater systems...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28667510/a-randomized-controlled-trial-of-ganaxolone-in-posttraumatic-stress-disorder
#6
Ann M Rasmusson, Christine E Marx, Sonia Jain, Gail M Farfel, Julia Tsai, Xiaoying Sun, Thomas D Geracioti, Mark B Hamner, James Lohr, Richard Rosse, Lanier Summerall, Jennifer C Naylor, Cristine Cusin, Ariel J Lang, Rema Raman, Murray B Stein
Preclinical and clinical research supports a role for neuroactive steroids in the pathophysiology of posttraumatic stress disorder (PTSD). We investigated ganaxolone (a synthetic 3β-methylated derivative of allopregnanolone, a GABAergic neuroactive steroid) for treatment of PTSD in a proof-of-concept, multisite, double-blind, placebo-controlled trial. Veteran and non-veteran participants (n = 112) were randomized to ganaxolone or placebo at biweekly escalating doses of 200, 400, and 600 mg twice daily for 6 weeks...
August 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28663287/carmil-family-proteins-as-multidomain-regulators-of-actin-based-motility
#7
Benjamin C Stark, M Hunter Lanier, John A Cooper
CARMILs are large multidomain proteins that regulate the actin-binding activity of capping protein (CP), a major capper of actin filament barbed ends in cells. CARMILs bind directly to CP and induce a conformational change that allosterically decreases but does not abolish its actin-capping activity. The CP-binding domain of CARMIL consists of the CP-interaction (CPI) and CARMIL-specific interaction (CSI) motifs, which are arranged in tandem. Many cellular functions of CARMILs require the interaction with CP; however, a more surprising result is that the cellular function of CP in cells appears to require binding to a CARMIL or another protein with a CPI motif, suggesting that CPI-motif proteins target CP and modulate its actin-capping activity...
July 1, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28659656/type-ii-endometrial-cancer-overexpresses-nilco-a-preliminary-evaluation
#8
Danielle Daley-Brown, Gabriela Oprea-Iles, Kiara T Vann, Viola Lanier, Regina Lee, Pierre V Candelaria, Alexander Quarshie, Roland Pattillo, Ruben Rene Gonzalez-Perez
OBJECTIVE: The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) and the association with obesity were investigated in types I and II endometrial cancer (EmCa). Additionally, the involvement of NILCO in leptin-induced invasiveness of EmCa cells was investigated. METHODS: The expression of NILCO mRNAs and proteins were analyzed in EmCa from African-American (n = 29) and Chinese patients (tissue array, n = 120 cases). The role of NILCO in leptin-induced invasion of Ishikawa and An3ca EmCa cells was investigated using Notch, IL-1, and leptin signaling inhibitors...
2017: Disease Markers
https://www.readbyqxmd.com/read/28655861/in-silico-modeling-identifies-cd45-as-a-regulator-of-il-2-synergy-in-the-nkg2d-mediated-activation-of-immature-human-nk-cells
#9
Sayak Mukherjee, Helle Jensen, William Stewart, David Stewart, William C Ray, Shih-Yu Chen, Garry P Nolan, Lewis L Lanier, Jayajit Das
Natural killer (NK) cells perform immunosurveillance of virally infected and transformed cells, and their activation depends on the balance between signaling by inhibitory and activating receptors. Cytokine receptor signaling can synergize with activating receptor signaling to induce NK cell activation. We investigated the interplay between the signaling pathways stimulated by the cytokine interleukin-2 (IL-2) and the activating receptor NKG2D in immature (CD56(bright)) and mature (CD56(dim)) subsets of human primary NK cells using mass cytometry experiments and in silico modeling...
June 27, 2017: Science Signaling
https://www.readbyqxmd.com/read/28618202/effects-of-persistent-fontan-fenestration-patency-on-cardiopulmonary-exercise-testing-variables
#10
M Elisabeth Heal, Lanier B Jackson, Andrew M Atz, Ryan J Butts
Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation. Effects of persistent fenestration on CPET variables have not been clearly defined. Associations between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration -4.9 ± 3.8 v. nonfenestration -3 ± 3...
June 15, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28602376/left-ventricular-assist-device-in-older-adults
#11
REVIEW
Chris Caraang, Gregg M Lanier, Alan Gass, Wilbert S Aronow, Chhaya Aggarwal Gupta
Left ventricular assist devices (LVADs) are an effective therapy for a growing and aging population in the background of limited donor supply. Selecting the proper patient involves assessment of indications, risk factors, scores for overall outcomes, assessment for right ventricular failure, and optimal timing of implantation. LVAD complications have a 5% to 10% perioperative mortality and complications of bleeding, thrombosis, stroke, infection, right ventricular failure, and device failure. As LVAD engineering technology evolves, so will the risk-prediction scores...
July 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28601422/exposure-to-surgery-and-anesthesia-after-concussion-due-to-mild-traumatic-brain-injury
#12
Arnoley S Abcejo, Rodolfo Savica, William L Lanier, Jeffrey J Pasternak
OBJECTIVE: To describe the epidemiology of surgical and anesthetic procedures in patients recently diagnosed as having a concussion due to mild traumatic brain injury. PATIENTS AND METHODS: Study patients presented to a tertiary care center after a concussion due to mild traumatic brain injury from July 1, 2005, through June 30, 2015, and underwent a surgical procedure and anesthesia support under the direct or indirect care of a physician anesthesiologist. RESULTS: During the study period, 1038 patients met all the study inclusion criteria and subsequently received 1820 anesthetics...
July 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28578780/an-editor-s-walk-with-mayo-clinic-proceedings-1999-2017-promises-aspirations-and-reflections
#13
EDITORIAL
William L Lanier
No abstract text is available yet for this article.
June 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28564542/repurposing-suzuki-coupling-reagents-as-a-directed-fragment-library-targeting-serine-hydrolases-and-related-enzymes
#14
Marion Lanier, Derek C Cole, Yelena Istratiy, Michael G Klein, Phillip A Schwartz, Richard Tjhen, Andy Jennings, Mark S Hixon
Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chemically diverse boronic acid fragments are commercially available because of their utility in coupling chemistry. We repurposed the approximately 650 boronic acid reagents in our collection as a directed fragment library targeting serine hydrolases and related enzymes. Highly efficient hits (LE > 0.6) often result. The utility of the approach is illustrated with the results against autotaxin, a phospholipase implicated in cardiovascular disease...
June 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28549460/learning-to-use-electronic-health-records-can-we-stay-patient-centered-a-pre-post-intervention-study-with-family-medicine-residents
#15
Cédric Lanier, Melissa Dominicé Dao, Patricia Hudelson, Bernard Cerutti, Noëlle Junod Perron
BACKGROUND: The Electronic Health Record (EHR) is now widely used in clinical encounters. Because its use can negatively impact the physician-patient relationship, several recommendations on the "patient-centered" use of the EHR have been published. However, the impact of training to improve EHR use during clinical encounters is not well known. The aim of this study was to assess the impact of training on residents' EHR-related communication skills and explore whether they varied according to the content of the consultation...
May 26, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28506527/ancestral-interactions-of-ribosomal-rna-and-ribosomal-proteins
#16
Kathryn A Lanier, Poorna Roy, Dana M Schneider, Loren Dean Williams
We have proposed that the ancient ribosome increased in size during early evolution by addition of small folding-competent RNAs. In this Accretion Model, small RNAs and peptides were subsumed onto subunit surfaces, gradually encasing and freezing previously acquired components. The model predicts that appropriate rRNA fragments have inherited local autonomy of folding and local autonomy of assembly with ribosomal proteins (rProteins), and that the rProtein and rRNA are co-chaperones. To test these predictions, we investigate the rRNA interactions of rProtein uL23 and its tail, uL23(tail), which is a β-hairpin that penetrates deep into the core of the large ribosomal subunit...
May 12, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28502572/-it-was-a-learning-experience-lessons-learned-from-young-african-american-men-and-women-s-sexual-debut
#17
Yzette Lanier, Jennifer Hettenbach, Khadijah Stoute, Lauren Hollender, Griffin Sutherland, Jennifer Stewart
No abstract text is available yet for this article.
April 24, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28458960/current-risk-stratification-systems-are-not-generalizable-across-surgical-technique-in-midline-ventral-hernia-repair
#18
Jennifer E Fligor, Steven T Lanier, Gregory A Dumanian
BACKGROUND: Current ventral hernia repair risk estimation tools focus on patient comorbidities with the goal of improving clinical outcomes through improved patient selection. However, their predictive value remains unproven. METHODS: Outcomes of patients who underwent midline ventral hernia repair with retrorectus placement of mid-weight soft polypropylene mesh between 2010 and 2015 were retrospectively reviewed and compared with predicted wound-related complication risk from 3 tools in the literature: Carolinas Equation for Determining Associated Risk, the Ventral Hernia Working Group (VHWG) grade, and a modified VHWG grade...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28453370/school-absence-and-productivity-outcomes-associated-with-childhood-asthma-in-the-usa
#19
Patrick Sullivan, Vahram G Ghushchyan, Prakash Navaratnam, Howard S Friedman, Abhisek Kavati, Benjamin Ortiz, Bob Lanier
BACKGROUND: Previous studies have examined the association between childhood asthma and lost productivity; however, more data are needed to understand its impact. METHODS: This was a retrospective analysis of cross-sectional data in the nationally representative 2007-2013 Medical Expenditure Panel Survey (MEPS). School-aged children (SAC), children (age 6-11), and adolescents (age 12-17) with asthma were compared to those without asthma to examine annual missed school days...
April 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28445367/adipose-tissue-drives-response-to-ischemia-reperfusion-injury-in-a-murine-pressure-sore-model
#20
Madeleine J Gust, Seok Jong Hong, Robert C Fang, Steven T Lanier, Donald W Buck, Jennifer M Nuñez, Shengxian Jia, Eugene D Park, Robert D Galiano, Thomas A Mustoe
BACKGROUND: Ischemia-reperfusion injury contributes significantly to the pathogenesis of chronic wounds such as pressure sores and diabetic foot ulcers. The authors' laboratory has previously developed a cyclical murine ischemia-reperfusion injury model. The authors here use this model to determine factors underlying tissue response to ischemia-reperfusion injury. METHODS: C57BL/6 mice were subjected to cycles of ischemia-reperfusion that varied in number (one to four cycles) and duration of ischemia (1 to 2 hours)...
May 2017: Plastic and Reconstructive Surgery
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