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https://www.readbyqxmd.com/read/28405897/culturally-relevant-online-cancer-education-modules-empower-alaska-s-community-health-aides-practitioners-to-disseminate-cancer-information-and-reduce-cancer-risk
#1
Katie Cueva, Laura Revels, Melany Cueva, Anne P Lanier, Mark Dignan, K Viswanath, Teresa T Fung, Alan C Geller
To address a desire for timely, medically accurate cancer education in rural Alaska, ten culturally relevant online learning modules were developed with, and for, Alaska's Community Health Aides/Practitioners (CHA/Ps). The project was guided by the framework of Community-Based Participatory Action Research, honored Indigenous Ways of Knowing, and was informed by Empowerment Theory. A total of 428 end-of-module evaluation surveys were completed by 89 unique Alaska CHA/Ps between January and December 2016. CHA/Ps shared that as a result of completing the modules, they were empowered to share cancer information with their patients, families, friends, and communities, as well as engage in cancer risk reduction behaviors such as eating healthier, getting cancer screenings, exercising more, and quitting tobacco...
April 12, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28393406/formal-synthesis-of-laurencin-via-a-gold-i-catalyzed-intramolecular-dehydrative-alkoxylation
#2
Megan L Lanier, Hyeri Park, Paramita Mukherjee, Jacob C Timmerman, Anthony A Ribero, Ross A Widenhoefer, Jiyong Hong
8-Membered cyclic ethers are found in a wide range of natural products; however, they are challenging synthetic targets due to enthalpic and entropic barriers. The gold(I)-catalyzed intramolecular dehydrative alkoxylation of -hydroxy allylic alcohols was explored to stereoselectively construct α,α΄-cis-oxocenes and applied in a formal synthesis of (+)-laurencin. The gold(I)-catalyzed intramolecular dehydrative alkoxylation may constitute an alternative method for the synthesis of molecular building blocks and natural products that contain highly functionalized 8-membered cyclic ethers...
April 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28385195/transition-of-editor-in-chief-duties-at-mayo-clinic-proceedings
#3
EDITORIAL
William L Lanier, Karl A Nath
No abstract text is available yet for this article.
April 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28365427/classification-of-maltreatment-related-mortality-by-child-death-review-teams-how-reliable-are-they
#4
Jared W Parrish, Patricia G Schnitzer, Paul Lanier, Meghan E Shanahan, Julie L Daniels, Steven W Marshall
Accurate estimation of the incidence of maltreatment-related child mortality depends on reliable child fatality review. We examined the inter-rater reliability of maltreatment designation for two Alaskan Child Death Review (CDR) panels. Two different multidisciplinary CDR panels each reviewed a series of 101 infant and child deaths (ages 0-4 years) in Alaska. Both panels independently reviewed identical medical, autopsy, law enforcement, child welfare, and administrative records for each death utilizing the same maltreatment criteria...
March 30, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28343970/phenylmethimazole-and-a-thiazole-derivative-of-phenylmethimazole-inhibit-il-6-expression-by-triple-negative-breast-cancer-cells
#5
Mahboubeh S Noori, John D O'Brien, Zachary J Champa, Sudhir P Deosarkar, Olivia L Lanier, Chunyan Qi, Monica M Burdick, Frank L Schwartz, Stephen C Bergmeier, Kelly D McCall, Douglas J Goetz
Inhibition of interleukin-6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have identified a more potent derivative of C10 termed COB-141. In the present work, we tested the hypothesis that C10 and COB-141 inhibit TNBC cell expressed IL-6 and investigated the potential for classical IL-6 pathway induced signaling within TNBC cells. A panel of TNBC cell lines (MDA-MB-231, Hs578T, MDA-MB-468) was used...
March 23, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28337323/structure-based-design-of-ask1-inhibitors-as-potential-agents-for-heart-failure
#6
Marion Lanier, Jason Pickens, Simone V Bigi, Erica L Bradshaw-Pierce, Alison Chambers, Zacharia S Cheruvallath, Derek Cole, Douglas R Dougan, Jacques Ermolieff, Tony Gibson, Petro Halkowycz, Aki Hirokawa, Anthony Ivetac, Joanne Miura, Evan Nunez, Mark Sabat, John Tyhonas, Haixia Wang, Xiaolun Wang, Steve Swann
Apoptosis signal-regulating kinase 1 (ASK1/MAP3K) is a mitogen-activated protein kinase family member shown to contribute to acute ischemia/reperfusion injury. Using structure-based drug design, deconstruction, and reoptimization of a known ASK1 inhibitor, a lead compound was identified. This compound displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28334877/iron-mediates-catalysis-of-nucleic-acid-processing-enzymes-support-for-fe-ii-as-a-cofactor-before-the-great-oxidation-event
#7
C Denise Okafor, Kathryn A Lanier, Anton S Petrov, Shreyas S Athavale, Jessica C Bowman, Nicholas V Hud, Loren Dean Williams
Life originated in an anoxic, Fe2+-rich environment. We hypothesize that on early Earth, Fe2+ was a ubiquitous cofactor for nucleic acids, with roles in RNA folding and catalysis as well as in processing of nucleic acids by protein enzymes. In this model, Mg2+ replaced Fe2+ as the primary cofactor for nucleic acids in parallel with known metal substitutions of metalloproteins, driven by the Great Oxidation Event. To test predictions of this model, we assay the ability of nucleic acid processing enzymes, including a DNA polymerase, an RNA polymerase and a DNA ligase, to use Fe2+ in place of Mg2+ as a cofactor during catalysis...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28287747/assessment-of-gold-nanoparticle-mediated-enhanced-hyperthermia-using-mr-guided-high-intensity-focused-ultrasound-ablation-procedure
#8
Surendra B Devarakonda, Matthew R Myers, Mathew Lanier, Charles Dumoulin, Rupak K Banerjee
High-intensity focused ultrasound (HIFU) has gained increasing popularity as a noninvasive therapeutic procedure to treat solid tumors. However, collateral damage due to the use of high acoustic powers during HIFU procedures remains a challenge. The objective of this study is to assess the utility of using gold nanoparticles (gNPs) during HIFU procedures to locally enhance heating at low powers, thereby reducing the likelihood of collateral damage. Phantoms containing tissue-mimicking material (TMM) and physiologically relevant concentrations (0%, 0...
March 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28259225/call-for-papers-on-clinical-practice-guidelines
#9
EDITORIAL
Tom D Thacher, S Vincent Rajkumar, William L Lanier
No abstract text is available yet for this article.
March 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28258138/quantifying-the-importance-of-the-rare-biosphere-for-microbial-community-response-to-organic-pollutants-in-a-freshwater-ecosystem
#10
Yuanqi Wang, Janet K Hatt, Despina Tsementzi, Luis M Rodriguez-R, Carlos A Ruiz-Pérez, Michael R Weigand, Heidi Kizer, Gina Maresca, Raj Krishnan, Rachel Poretsky, Jim C Spain, Konstantinos T Konstantinidis
A single liter of water contains hundreds, if not thousands, of bacterial and archaeal species, each of which typically makes up a very small fraction of the total microbial community (<0.1%), the so-called "rare biosphere." How often, and via what mechanisms, e.g., clonal amplification versus horizontal gene transfer, the rare taxa and genes contribute to microbial community response to environmental perturbations represent important unanswered questions toward better understanding the value and modeling of microbial diversity...
April 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28246585/nanoparticle-linked-antagonist-for-leptin-signaling-inhibition-in-breast-cancer
#11
Tia Harmon, Adriana Harbuzariu, Viola Lanier, Crystal C Lipsey, Ward Kirlin, Lily Yang, Ruben R Gonzalez-Perez
AIM: To develop a leptin peptide receptor antagonist linked to nanoparticles and determine its effect on viability of breast cancer cells. METHODS: The leptin antagonist, LPrA2, was coupled via EDAC [1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide] to iron oxide nanoparticles (IONP-LPrA2) to increase its efficacy. IONP-LPrA2 conjugation was confirmed by Western blot and nanoparticle tracking analysis. Human triple negative breast cancer (TNBC) MDA-MB-231, HCC1806 and estrogen receptor positive (ER(+)) MCF-7 cells were analyzed for the expression of the leptin receptor, Ob-R...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28243688/the-origin-of-life-models-and-data
#12
Kathryn A Lanier, Loren Dean Williams
A general framework for conventional models of the origin of life (OOL) is the specification of a 'privileged function.' A privileged function is an extant biological function that is excised from its biological context, elevated in importance over other functions, and transported back in time to a primitive chemical or geological environment. In RNA or Clay Worlds, the privileged function is replication. In Metabolism-First Worlds, the privileged function is metabolism. In Thermal Vent Worlds, the privileged function is energy harvesting from chemical gradients...
March 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/28225471/neuroanesthesiology-update
#13
Jeffrey J Pasternak, William L Lanier
We reviewed manuscripts published in 2016 that are related to the care of neurosurgical patients or the perioperative care of patients with neurological diseases. We address the broad categories of general neurosurgery and neuroanesthesiology, anesthetic neurotoxicity and neuroprotection, stroke, traumatic brain injury, and nervous system monitoring.
April 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28201543/frozen-in-time-the-history-of-proteins
#14
Nicholas A Kovacs, Anton S Petrov, Kathryn A Lanier, Loren Dean Williams
The ribosome is imprinted with a detailed molecular chronology of the origins and early evolution of proteins. Here we show that when arranged by evolutionary phase of ribosomal evolution, ribosomal protein (rProtein) segments reveal an atomic level history of protein folding. The data support a model in which aboriginal oligomers evolved into globular proteins in a hierarchical step-wise process. Complexity of assembly and folding of polypeptide increased incrementally in concert with expansion of rRNA. (i) Short random coil proto-peptides bound to rRNA, and (ii) lengthened over time and coalesced into β-β secondary elements...
May 1, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28197178/tdp-43-overexpression-impairs-presynaptic-integrity
#15
Lanier Heyburn, Charbel E-H Moussa
No abstract text is available yet for this article.
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28185556/a-performance-study-of-the-impact-of-recombination-on-species-tree-analysis
#16
Zhiwei Wang, Kevin J Liu
BACKGROUND: The most widely used state-of-the-art methods for reconstructing species phylogenies from genomic sequence data assume that sampled loci are identically and independently distributed. In principle, free recombination between loci and a lack of intra-locus recombination are necessary to satisfy this assumption. Few studies have quantified the practical impact of recombination on species tree inference methods, and even fewer have used genomic sequence data for this purpose...
November 11, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28165478/a-distinct-innate-lymphoid-cell-population-regulates-tumor-associated-t-cells
#17
Sarah Q Crome, Linh T Nguyen, Sandra Lopez-Verges, S Y Cindy Yang, Bernard Martin, Jennifer Y Yam, Dylan J Johnson, Jessica Nie, Michael Pniak, Pei Hua Yen, Anca Milea, Ramlogan Sowamber, Sarah Rachel Katz, Marcus Q Bernardini, Blaise A Clarke, Patricia A Shaw, Philipp A Lang, Hal K Berman, Trevor J Pugh, Lewis L Lanier, Pamela S Ohashi
Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56(+)CD3(-) population in TIL cultures was associated with reduced T cell numbers, and further functional studies demonstrated that this population suppressed TIL expansion and altered TIL cytokine production...
March 2017: Nature Medicine
https://www.readbyqxmd.com/read/28143936/ebi3-regulates-the-nk-cell-response-to-mouse-cytomegalovirus-infection
#18
Helle Jensen, Shih-Yu Chen, Lasse Folkersen, Garry P Nolan, Lewis L Lanier
Natural killer (NK) cells are key mediators in the control of cytomegalovirus infection. Here, we show that Epstein-Barr virus-induced 3 (EBI3) is expressed by human NK cells after NKG2D or IL-12 plus IL-18 stimulation and by mouse NK cells during mouse cytomegalovirus (MCMV) infection. The induction of EBI3 protein expression in mouse NK cells is a late activation event. Thus, early activation events of NK cells, such as IFNγ production and CD69 expression, were not affected in EBI3-deficient (Ebi3(-/-) ) C57BL/6 (B6) mice during MCMV infection...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28113194/development-of-novel-3-d-printed-scaffolds-with-core-shell-nanoparticles-for-nerve-regeneration
#19
Se-Jun Lee, Wei Zhu, Lanier Heyburn, Margaret Nowicki, Brent Harris, Lijie Grace Zhang
A traumatic injury of peripheral nerves is serious clinical problem that may lead to major loss of nerve function, affecting quality of patient's life. Currently, nerve autograft is widely used to reconstruct the nerve gap. However, such surgical procedure suffers from many disadvantages including donor site morbidity and limited availability. In order to address these issues, neural tissue engineering has focused on the development of synthetic nerve scaffolds to support bridging a larger gap and improving nerve generation...
February 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28062065/expanding-the-mayo-clinic-proceedings-mission-introducing-mayo-clinic-proceedings-innovations-quality-outcomes-mcp-iq-o
#20
EDITORIAL
William L Lanier, Thomas C Gerber
No abstract text is available yet for this article.
January 2017: Mayo Clinic Proceedings
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