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https://www.readbyqxmd.com/read/29163499/fc%C3%AE%C2%B5ri-%C3%AE-chain-negatively-modulates-dectin-1-responses-in-dendritic-cells
#1
Yi-Gen Pan, Yen-Ling Yu, Chi-Chien Lin, Lewis L Lanier, Ching-Liang Chu
The inhibitory effect of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and FcεRI γ-chain (FcRγ) has been found in many immune functions. Herein, we have further explored the role of these adapters in C-type lectin receptors response. We identified that FcRγ, but not DAP12, could negatively regulate the Dectin-1 responses in dendritic cells (DCs). Loss of FcRγ or both DAP12 and FcRγ enhanced the maturation and cytokine production in DCs upon Dectin-1 activation compared to normal cells, whereas DCs lacking only DAP12 showed little changes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29135896/vertical-skin-paddle-orientation-for-the-latissimus-dorsi-flap-in-breast-reconstruction-a-modification-to-simultaneously-correct-inferior-pole-constriction-and-improve-projection
#2
Megan Fracol, Michelle Grim, Steven Lanier, Neil A Fine
The latissimus dorsi myocutaneous flap (LDMF) is a reliable and frequently used option to bring vascularized skin and soft tissue to improve the stability and aesthetic result in breast reconstruction. Standard techniques with skin paddle inset in a horizontal or oblique fashion preferentially improve anterior projection (when inset at the mastectomy scar) or lower pole and infra-mammary fold (IMF) constriction (when inset into the IMF). Here, we describe a modification for inset of the LDMF that improves both anterior projection and lower pole/IMF constriction, while also allowing the latissimus muscle to fan out and provide complete implant coverage...
November 8, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29124398/patient-perceptions-of-glucocorticoids-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#3
Joanna C Robson, Jill Dawson, Peter F Cronholm, Susan Ashdown, Ebony Easley, Katherine S Kellom, Don Gebhart, Georgia Lanier, Nataliya Milman, Jacqueline Peck, Raashid A Luqmani, Judy A Shea, Gunnar Tomasson, Peter A Merkel
Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) are multisystem diseases of small blood vessels, collectively known as the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). This study explores the patient's perspective on the use of glucocorticoids, which are still a mainstay of treatment in AAV. Patients with AAV from the UK, USA, and Canada were interviewed, using purposive sampling to include a range of disease manifestations and demographics...
November 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29108644/mesh-sutured-repairs-of-contaminated-incisional-hernias
#4
Gregory A Dumanian, Steven T Lanier, Jason M Souza, Mimi Wu Young, Alexei S Mlodinow, Anne-Marie Boller, Kyle H Mueller, Amy L Halverson, Michael F McGee, Jonah J Stulberg
BACKGROUND: We sought to evaluate the results of a new mesh sutured repair technique for closure of contaminated incisional hernias. METHODS: 48 patients with contaminated hernias 5 cm wide or greater by CT scan were closed with mesh sutures. Surgical site occurrence, infections, and hernia recurrence were compared to similar patient series reported in the literature. RESULTS: Of the 48 patients, 20 had clean-contaminated wounds, 16 had contaminated wounds, and 12 were infected...
October 25, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29084373/residual-sodium-dodecyl-sulfate-in-decellularized-muscle-matrices-leads-to-fibroblast-activation-in-vitro-and-foreign-body-response-in-vivo
#5
Emily E Friedrich, Steven T Lanier, Soleil Niknam-Bienia, Gabriel A Arenas, Divya Rajendran, Jason A Wertheim, Robert D Galiano
Detergents such as sodium dodecyl sulfate (SDS) are commonly used to extract cells from tissues in a process called 'decellularization'. Residual SDS is difficult to completely remove and may lead to an undesirable host response toward an implanted biomaterial. In this study, we developed a modification for SDS cell extraction from muscle equally efficient to previous methods but leading to significantly less residual SDS remnants in the matrices. Muscle-derived matrices were prepared via two SDS-based decellularization methods, which led to removal of either 81...
October 30, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29017640/investigating-the-risk-of-date-rape-by-auditory-status
#6
LaVerne McQuiller Williams, Judy L Porter, Jason D Scott, Tony R Smith, Taylor V Vogt
This exploratory study examines the impact of auditory status, gender, and prior sexual victimization on attitudes andbehaviors related to date rape among undergraduate college students (n = 3,352) at a private university in the northeast. An abbreviated version of the College Date Rape Attitude and Behavior Survey (Lanier & Elliot, 1997) and the Sexual Experiences Survey (Koss, Gidycz, & Wisniewski, 1987) were employed. Findings indicated that Deaf and hard of hearing (DHH) students were more likely to experience negative sexual experiences than hearing students...
October 10, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28981368/the-national-burden-of-poorly-controlled-asthma-school-absence-and-parental-work-loss-among-school-aged-children-in-the-united-states
#7
P W Sullivan, V Ghushchyan, P Navaratnam, H S Friedman, A Kavati, B Ortiz, B Lanier
OBJECTIVE: The degree of poorly controlled asthma and its association with missed school days and parental missed work days is not well understood. METHODS: This was a retrospective analysis of missed school days and missed work days for school-aged children (SAC; aged 6-17) and their caregivers in the nationally representative 2007-2013 Medical Expenditure Panel Survey (MEPS). Indicators of poor asthma control included: exacerbation in previous 12 months; use of >3 canisters of short-acting beta agonist (SABA) in 3 months; and annual asthma-specific (AS) Emergency Department (ED) or inpatient (IP) visits...
October 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28956825/a-longitudinal-study-of-child-maltreatment-and-mental-health-predictors-of-admission-to-psychiatric-residential-treatment-facilities
#8
Roderick A Rose, Paul Lanier
The child welfare system is an access point for children's mental health services. Psychiatric residential treatment facilities (PRTFs) are the most restrictive, and most expensive setting for children to receive long-term care. Given the high rates of behavioral health concerns among maltreated children in out-of-home care, research is needed to examine the factors that predict entry in PRTFs among children investigated for maltreatment. This exploratory study used cross-sector administrative records linked across multiple systems, including child welfare records and Medicaid claims, from a single state over a five-year period (n = 105,982)...
September 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28932571/management-of-pulmonary-hypertension-from-left-heart-disease-in-candidates-for-orthotopic-heart-transplantation
#9
REVIEW
Anna Koulova, Alan L Gass, Saikrishna Patibandla, Chhaya Aggarwal Gupta, Wilbert S Aronow, Gregg M Lanier
Pulmonary hypertension in left heart disease (PH-LHD) commonly complicates prolonged heart failure (HF). When advanced, the PH becomes fixed or out of proportion and is associated with increased morbidity and mortality in patients undergoing orthotopic heart transplant (OHT). To date, the only recommended treatment of out of proportion PH is the treatment of the underlying HF by reducing the pulmonary capillary wedge pressure (PCWP) with medications and often along with use of mechanical circulatory support...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28929420/adverse-childhood-experiences-and-child-health-outcomes-comparing-cumulative-risk-and-latent-class-approaches
#10
Paul Lanier, Kathryn Maguire-Jack, Brianna Lombardi, Joseph Frey, Roderick A Rose
Objectives This study seeks to further the work exploring adverse childhood experiences (ACEs) by proposing a novel approach to understanding the impact of ACEs through applying advanced analytical methods to examine whether combinations of ACEs differentially impact child health outcomes. Methods Using National Survey of Children's Health data, we use latent class analysis to estimate associations between classes of ACEs and child health outcomes. Results Class membership predicts child poor health, with differences found for specific ACE combinations...
September 19, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28890020/the-national-cost-of-asthma-among-school-aged-children-in-the-united%C3%A2-states
#11
Patrick W Sullivan, Vahram Ghushchyan, Prakash Navaratnam, Howard S Friedman, Abhishek Kavati, Benjamin Ortiz, Bob Lanier
BACKGROUND: Recent research has quantified the national health care resource use (HCRU) and health care expenditure (HCE) burden associated with adult asthma; however, estimates specific to school-aged children are more than 2 decades old. OBJECTIVE: To estimate the national HCRU and HCEs attributable to asthma among school-aged children in the United States. METHODS: This was a cross-sectional retrospective analysis of school-aged children (aged 6-17 years) in the nationally representative 2007-2013 Medical Expenditure Panel Survey...
September 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28879015/connecting-the-dots-across-time-reconstruction-of-single-cell-signalling-trajectories-using-time-stamped-data
#12
Sayak Mukherjee, David Stewart, William Stewart, Lewis L Lanier, Jayajit Das
Single-cell responses are shaped by the geometry of signalling kinetic trajectories carved in a multidimensional space spanned by signalling protein abundances. It is, however, challenging to assay a large number (more than 3) of signalling species in live-cell imaging, which makes it difficult to probe single-cell signalling kinetic trajectories in large dimensions. Flow and mass cytometry techniques can measure a large number (4 to more than 40) of signalling species but are unable to track single cells...
August 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28864650/omeract-endorsement-of-patient-reported-outcome-instruments-in-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#13
Joanna C Robson, Gunnar Tomasson, Nataliya Milman, Sue Ashdown, Annelies Boonen, George C Casey, Peter F Cronholm, David Cuthbertson, Jill Dawson, Haner Direskeneli, Ebony Easley, Tanaz A Kermani, John T Farrar, Don Gebhart, Georgia Lanier, Raashid A Luqmani, Alfred Mahr, Carol A McAlear, Jacqueline Peck, Beverley Shea, Judy A Shea, Antoine G Sreih, Peter S Tugwell, Peter A Merkel
OBJECTIVE: The antineutrophil cytoplasmic antibody-associated vasculitides (AAV) are multiorgan diseases. Patients with AAV report impairment in their health-related quality of life (HRQOL) and have different priorities regarding disease assessment compared with physicians. The Outcome Measures in Rheumatology (OMERACT) Vasculitis Working Group previously received endorsement for a core set of domains in AAV. Two approaches to measure patient-reported outcomes (PRO) were presented at OMERACT 2016...
October 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28832374/chronic-thromboembolic-pulmonary-hypertension-epidemiology-diagnosis-and-management
#14
Srikanth Yandrapalli, Sohaib Tariq, Jessica Kumar, Wilbert S Aronow, Ramin Malekan, William H Frishman, Gregg M Lanier
Chronic thromboembolic pulmonary hypertension (CTEPH), classified as WHO group 4 pulmonary hypertension (PH), is an interesting and rare pulmonary vascular disorder secondary to mechanical obstruction of the pulmonary vasculature from thromboembolism resulting in PH. The pathophysiology is complex, beginning with mechanical obstruction of the pulmonary arteries, which eventually leads to arteriopathic changes and vascular remodeling in the non-occluded arteries and in the distal segments of the occluded arteries mediated by thrombus non-resolution, abnormal angiogenesis, endothelial dysfunction, and various local growth factors...
August 18, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/28815225/chronic-in-vivo-interaction-of-dendritic-cells-expressing-the-ligand-rae-1%C3%AE%C2%B5-with-nk-cells-impacts-nkg2d-expression-and-function
#15
Maelig G Morvan, Marine Champsaur, Boris Reizis, Lewis L Lanier
To investigate how dendritic cells (DCs) interact with NK cells in vivo, we developed a novel mouse model in which Rae-1ε, a ligand of the NKG2D receptor, is expressed in cells with high levels of CD11c. In these CD11c-Rae1 mice, expression of Rae-1 was confirmed on all subsets of DCs and a small subset of B and T cells, but not on NK cells. DC numbers and activation status were unchanged, and NK cells in these CD11c-Rae1 mice presented the same Ly49 repertoire and maturation levels as their littermate wildtype controls...
May 1, 2017: Immunohorizons
https://www.readbyqxmd.com/read/28762156/quantifying-sources-of-bias-in-longitudinal-data-linkage-studies-of-child-abuse-and-neglect-measuring-impact-of-outcome-specification-linkage-error-and-partial-cohort-follow-up
#16
Jared W Parrish, Meghan E Shanahan, Patricia G Schnitzer, Paul Lanier, Julie L Daniels, Stephen W Marshall
BACKGROUND: Health informatics projects combining statewide birth populations with child welfare records have emerged as a valuable approach to conducting longitudinal research of child maltreatment. The potential bias resulting from linkage misspecification, partial cohort follow-up, and outcome misclassification in these studies has been largely unexplored. This study integrated epidemiological survey and novel administrative data sources to establish the Alaska Longitudinal Child Abuse and Neglect Linkage (ALCANLink) project...
December 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/28760883/cutting-edge-nkg2d-signaling-enhances-nk-cell-responses-but-alone-is-insufficient-to-drive-expansion-during-mouse-cytomegalovirus-infection
#17
Tsukasa Nabekura, Dagmar Gotthardt, Kouta Niizuma, Tihana Trsan, Tina Jenus, Stipan Jonjic, Lewis L Lanier
NK cells play a critical role in host defense against viruses. In this study, we investigated the role of NKG2D in the expansion of NK cells after mouse CMV (MCMV) infection. Wild-type and NKG2D-deficient (Klrk1(-/-) ) Ly49H(+) NK cells proliferated robustly when infected with MCMV strains engineered to allow expression of NKG2D ligands, which enhanced the response of wild-type NK cells. Naive NK cells exclusively express NKG2D-L, which pairs only with DAP10, whereas NKG2D-S expressed by activated NK cells pairs with DAP10 and DAP12, similar to Ly49H...
September 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28747426/intestinal-epithelial-cell-endoplasmic-reticulum-stress-promotes-mult1-up-regulation-and-nkg2d-mediated-inflammation
#18
Shuhei Hosomi, Joep Grootjans, Markus Tschurtschenthaler, Niklas Krupka, Juan D Matute, Magdalena B Flak, Eduardo Martinez-Naves, Manuel Gomez Del Moral, Jonathan N Glickman, Mizuki Ohira, Lewis L Lanier, Arthur Kaser, Richard Blumberg
Endoplasmic reticulum (ER) stress is commonly observed in intestinal epithelial cells (IECs) and can, if excessive, cause spontaneous intestinal inflammation as shown by mice with IEC-specific deletion of X-box-binding protein 1 (Xbp1), an unfolded protein response-related transcription factor. In this study, Xbp1 deletion in the epithelium (Xbp1(ΔIEC) ) is shown to cause increased expression of natural killer group 2 member D (NKG2D) ligand (NKG2DL) mouse UL16-binding protein (ULBP)-like transcript 1 and its human orthologue cytomegalovirus ULBP via ER stress-related transcription factor C/EBP homology protein...
October 2, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28746291/state-of-the-plastic-surgery-workforce-and-the-impact-of-graduate-medical-education-reform-on-training-of-plastic-surgeons
#19
Lindsay Janes, Steven T Lanier, Gregory R D Evans, Steven J Kasten, Keith M Hume, Arun K Gosain
BACKGROUND: Although recent estimates predict a large impending shortage of plastic surgeons, graduate medical education funding through the Centers for Medicare and Medicaid Services remains capped by the 1997 Balanced Budget Act. The authors' aim was to develop a plan to stimulate legislative action. METHODS: The authors reviewed responses of the American Society of Plastic Surgeons, American College of Surgeons, and American Medical Association from January of 2015 to a House Energy & Commerce Committee request for input on graduate medical education funding...
August 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28735717/real-time-cineangiography-visualization-of-cerebral-aneurysm-rupture-in-an-awake-patient-anatomic-physiological-and-functional-correlates
#20
Tasha L Welch, Waleed Brinjikji, Guiseppe Lanzino, William L Lanier
Intracranial aneurysms are common and, on a population-based perspective, are a major cause of morbidity and mortality as a result of mass effect or rupture. Cerebral angiography is the primary technique used for the diagnosis of cerebral aneurysms, and the imaging data have additional utility for planning medical, endovascular, or surgical treatments. An extremely rare periprocedural complication of cerebral angiography is rupture of the aneurysm, either as a chance phenomenon or as a result of some physiologic change or mechanical effect...
September 2017: Mayo Clinic Proceedings
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