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https://www.readbyqxmd.com/read/28618202/effects-of-persistent-fontan-fenestration-patency-on-cardiopulmonary-exercise-testing-variables
#1
M Elisabeth Heal, Lanier B Jackson, Andrew M Atz, Ryan J Butts
Cardiopulmonary exercise testing (CPET) aids in clinical assessment of patients with Fontan circulation. Effects of persistent fenestration on CPET variables have not been clearly defined. Associations between fenestration and CPET variables at anaerobic threshold (AT) and peak exercise were explored in the Pediatric Heart Network Fontan Cross-Sectional Study cohort. Fenestration patency was associated with a greater decrease in oxygen saturation from rest to peak exercise (fenestration -4.9 ± 3.8 v. nonfenestration -3 ± 3...
June 15, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28602376/left-ventricular-assist-device-in-older-adults
#2
REVIEW
Chris Caraang, Gregg M Lanier, Alan Gass, Wilbert S Aronow, Chhaya Aggarwal Gupta
Left ventricular assist devices (LVADs) are an effective therapy for a growing and aging population in the background of limited donor supply. Selecting the proper patient involves assessment of indications, risk factors, scores for overall outcomes, assessment for right ventricular failure, and optimal timing of implantation. LVAD complications have a 5% to 10% perioperative mortality and complications of bleeding, thrombosis, stroke, infection, right ventricular failure, and device failure. As LVAD engineering technology evolves, so will the risk-prediction scores...
July 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28601422/exposure-to-surgery-and-anesthesia-after-concussion-due-to-mild-traumatic-brain-injury
#3
Arnoley S Abcejo, Rodolfo Savica, William L Lanier, Jeffrey J Pasternak
OBJECTIVE: To describe the epidemiology of surgical and anesthetic procedures in patients recently diagnosed as having a concussion due to mild traumatic brain injury. PATIENTS AND METHODS: Study patients presented to a tertiary care center after a concussion due to mild traumatic brain injury from July 1, 2005, through June 30, 2015, and underwent a surgical procedure and anesthesia support under the direct or indirect care of a physician anesthesiologist. RESULTS: During the study period, 1038 patients met all the study inclusion criteria and subsequently received 1820 anesthetics...
June 7, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28578780/an-editor-s-walk-with-mayo-clinic-proceedings-1999-2017-promises-aspirations-and-reflections
#4
EDITORIAL
William L Lanier
No abstract text is available yet for this article.
June 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28564542/repurposing-suzuki-coupling-reagents-as-a-directed-fragment-library-targeting-serine-hydrolases-and-related-enzymes
#5
Marion Lanier, Derek C Cole, Yelena Istratiy, Michael G Klein, Phillip A Schwartz, Richard Tjhen, Andy Jennings, Mark S Hixon
Serine hydrolases are susceptible to potent reversible inhibition by boronic acids. Large collections of chemically diverse boronic acid fragments are commercially available because of their utility in coupling chemistry. We repurposed the approximately 650 boronic acid reagents in our collection as a directed fragment library targeting serine hydrolases and related enzymes. Highly efficient hits (LE > 0.6) often result. The utility of the approach is illustrated with the results against autotaxin, a phospholipase implicated in cardiovascular disease...
June 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28549460/learning-to-use-electronic-health-records-can-we-stay-patient-centered-a-pre-post-intervention-study-with-family-medicine-residents
#6
Cédric Lanier, Melissa Dominicé Dao, Patricia Hudelson, Bernard Cerutti, Noëlle Junod Perron
BACKGROUND: The Electronic Health Record (EHR) is now widely used in clinical encounters. Because its use can negatively impact the physician-patient relationship, several recommendations on the "patient-centered" use of the EHR have been published. However, the impact of training to improve EHR use during clinical encounters is not well known. The aim of this study was to assess the impact of training on residents' EHR-related communication skills and explore whether they varied according to the content of the consultation...
May 26, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28506527/ancestral-interactions-of-ribosomal-rna-and-ribosomal-proteins
#7
Kathryn A Lanier, Poorna Roy, Dana M Schneider, Loren Dean Williams
We have proposed that the ancient ribosome increased in size during early evolution by addition of small folding-competent RNAs. In this Accretion Model, small RNAs and peptides were subsumed onto subunit surfaces, gradually encasing and freezing previously acquired components. The model predicts that appropriate rRNA fragments have inherited local autonomy of folding and local autonomy of assembly with ribosomal proteins (rProteins), and that the rProtein and rRNA are co-chaperones. To test these predictions, we investigate the rRNA interactions of rProtein uL23 and its tail, uL23(tail), which is a β-hairpin that penetrates deep into the core of the large ribosomal subunit...
May 12, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28502572/-it-was-a-learning-experience-lessons-learned-from-young-african-american-men-and-women-s-sexual-debut
#8
Yzette Lanier, Jennifer Hettenbach, Khadijah Stoute, Lauren Hollender, Griffin Sutherland, Jennifer Stewart
No abstract text is available yet for this article.
April 24, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28458960/current-risk-stratification-systems-are-not-generalizable-across-surgical-technique-in-midline-ventral-hernia-repair
#9
Jennifer E Fligor, Steven T Lanier, Gregory A Dumanian
BACKGROUND: Current ventral hernia repair risk estimation tools focus on patient comorbidities with the goal of improving clinical outcomes through improved patient selection. However, their predictive value remains unproven. METHODS: Outcomes of patients who underwent midline ventral hernia repair with retrorectus placement of mid-weight soft polypropylene mesh between 2010 and 2015 were retrospectively reviewed and compared with predicted wound-related complication risk from 3 tools in the literature: Carolinas Equation for Determining Associated Risk, the Ventral Hernia Working Group (VHWG) grade, and a modified VHWG grade...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28453370/school-absence-and-productivity-outcomes-associated-with-childhood-asthma-in-the-usa
#10
Patrick Sullivan, Vahram G Ghushchyan, Prakash Navaratnam, Howard S Friedman, Abhisek Kavati, Benjamin Ortiz, Bob Lanier
BACKGROUND: Previous studies have examined the association between childhood asthma and lost productivity; however, more data are needed to understand its impact. METHODS: This was a retrospective analysis of cross-sectional data in the nationally representative 2007-2013 Medical Expenditure Panel Survey (MEPS). School-aged children (SAC), children (age 6-11), and adolescents (age 12-17) with asthma were compared to those without asthma to examine annual missed school days...
April 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28445367/adipose-tissue-drives-response-to-ischemia-reperfusion-injury-in-a-murine-pressure-sore-model
#11
Madeleine J Gust, Seok Jong Hong, Robert C Fang, Steven T Lanier, Donald W Buck, Jennifer M Nuñez, Shengxian Jia, Eugene D Park, Robert D Galiano, Thomas A Mustoe
BACKGROUND: Ischemia-reperfusion injury contributes significantly to the pathogenesis of chronic wounds such as pressure sores and diabetic foot ulcers. The authors' laboratory has previously developed a cyclical murine ischemia-reperfusion injury model. The authors here use this model to determine factors underlying tissue response to ischemia-reperfusion injury. METHODS: C57BL/6 mice were subjected to cycles of ischemia-reperfusion that varied in number (one to four cycles) and duration of ischemia (1 to 2 hours)...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28444628/moving-beyond-age-an-exploratory-qualitative-study-on-the-context-of-young-african-american-men-and-women-s-sexual-debut
#12
Yzette Lanier, Jennifer M Stewart, Jean J Schensul, Barbara J Guthrie
African American youth continue to be disproportionately affected by HIV. Early sexual debut has been identified as a major determinant of HIV risk. However, emerging research suggests that the overarching context in which first sex occurs may have greater implications for sexual health than simply age alone. The purpose of this exploratory, qualitative study was to better understand the broader context of African Americans' sexual debut. In-depth, semi-structured interviews were conducted with 10 African American men and women aged 18-24 years...
April 25, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28405897/culturally-relevant-online-cancer-education-modules-empower-alaska-s-community-health-aides-practitioners-to-disseminate-cancer-information-and-reduce-cancer-risk
#13
Katie Cueva, Laura Revels, Melany Cueva, Anne P Lanier, Mark Dignan, K Viswanath, Teresa T Fung, Alan C Geller
To address a desire for timely, medically accurate cancer education in rural Alaska, ten culturally relevant online learning modules were developed with, and for, Alaska's Community Health Aides/Practitioners (CHA/Ps). The project was guided by the framework of Community-Based Participatory Action Research, honored Indigenous Ways of Knowing, and was informed by Empowerment Theory. A total of 428 end-of-module evaluation surveys were completed by 89 unique Alaska CHA/Ps between January and December 2016. CHA/Ps shared that as a result of completing the modules, they were empowered to share cancer information with their patients, families, friends, and communities, as well as engage in cancer risk reduction behaviors such as eating healthier, getting cancer screenings, exercising more, and quitting tobacco...
April 12, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28393406/formal-synthesis-of-laurencin-by-gold-i-catalyzed-intramolecular-dehydrative-alkoxylation
#14
Megan L Lanier, Hyeri Park, Paramita Mukherjee, Jacob C Timmerman, Anthony A Ribeiro, Ross A Widenhoefer, Jiyong Hong
8-Membered cyclic ethers are found in a wide range of natural products; however, they are challenging synthetic targets due to enthalpic and entropic barriers. The gold(I)-catalyzed intramolecular dehydrative alkoxylation of ω-hydroxy allylic alcohols was explored to stereoselectively construct α,α'-cis-oxocenes and further applied in a formal synthesis of (+)-laurencin. The gold(I)-catalyzed intramolecular dehydrative alkoxylation may constitute an alternative method for the synthesis of molecular building blocks and natural products that contain highly functionalized 8-membered cyclic ethers...
April 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28385195/transition-of-editor-in-chief-duties-at-mayo-clinic-proceedings
#15
EDITORIAL
William L Lanier, Karl A Nath
No abstract text is available yet for this article.
April 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28365427/classification-of-maltreatment-related-mortality-by-child-death-review-teams-how-reliable-are-they
#16
Jared W Parrish, Patricia G Schnitzer, Paul Lanier, Meghan E Shanahan, Julie L Daniels, Steven W Marshall
Accurate estimation of the incidence of maltreatment-related child mortality depends on reliable child fatality review. We examined the inter-rater reliability of maltreatment designation for two Alaskan Child Death Review (CDR) panels. Two different multidisciplinary CDR panels each reviewed a series of 101 infant and child deaths (ages 0-4 years) in Alaska. Both panels independently reviewed identical medical, autopsy, law enforcement, child welfare, and administrative records for each death utilizing the same maltreatment criteria...
March 30, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28343970/phenylmethimazole-and-a-thiazole-derivative-of-phenylmethimazole-inhibit-il-6-expression-by-triple-negative-breast-cancer-cells
#17
Mahboubeh S Noori, John D O'Brien, Zachary J Champa, Sudhir P Deosarkar, Olivia L Lanier, Chunyan Qi, Monica M Burdick, Frank L Schwartz, Stephen C Bergmeier, Kelly D McCall, Douglas J Goetz
Inhibition of interleukin-6 (IL-6) holds significant promise as a therapeutic approach for triple negative breast cancer (TNBC). We previously reported that phenylmethimazole (C10) reduces IL-6 expression in several cancer cell lines. We have identified a more potent derivative of C10 termed COB-141. In the present work, we tested the hypothesis that C10 and COB-141 inhibit TNBC cell expressed IL-6 and investigated the potential for classical IL-6 pathway induced signaling within TNBC cells. A panel of TNBC cell lines (MDA-MB-231, Hs578T, MDA-MB-468) was used...
May 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28337323/structure-based-design-of-ask1-inhibitors-as-potential-agents-for-heart-failure
#18
Marion Lanier, Jason Pickens, Simone V Bigi, Erica L Bradshaw-Pierce, Alison Chambers, Zacharia S Cheruvallath, Derek Cole, Douglas R Dougan, Jacques Ermolieff, Tony Gibson, Petro Halkowycz, Aki Hirokawa, Anthony Ivetac, Joanne Miura, Evan Nunez, Mark Sabat, John Tyhonas, Haixia Wang, Xiaolun Wang, Steve Swann
Apoptosis signal-regulating kinase 1 (ASK1/MAP3K) is a mitogen-activated protein kinase family member shown to contribute to acute ischemia/reperfusion injury. Using structure-based drug design, deconstruction, and reoptimization of a known ASK1 inhibitor, a lead compound was identified. This compound displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.
March 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28334877/iron-mediates-catalysis-of-nucleic-acid-processing-enzymes-support-for-fe-ii-as-a-cofactor-before-the-great-oxidation-event
#19
C Denise Okafor, Kathryn A Lanier, Anton S Petrov, Shreyas S Athavale, Jessica C Bowman, Nicholas V Hud, Loren Dean Williams
Life originated in an anoxic, Fe2+-rich environment. We hypothesize that on early Earth, Fe2+ was a ubiquitous cofactor for nucleic acids, with roles in RNA folding and catalysis as well as in processing of nucleic acids by protein enzymes. In this model, Mg2+ replaced Fe2+ as the primary cofactor for nucleic acids in parallel with known metal substitutions of metalloproteins, driven by the Great Oxidation Event. To test predictions of this model, we assay the ability of nucleic acid processing enzymes, including a DNA polymerase, an RNA polymerase and a DNA ligase, to use Fe2+ in place of Mg2+ as a cofactor during catalysis...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28287747/assessment-of-gold-nanoparticle-mediated-enhanced-hyperthermia-using-mr-guided-high-intensity-focused-ultrasound-ablation-procedure
#20
Surendra B Devarakonda, Matthew R Myers, Mathew Lanier, Charles Dumoulin, Rupak K Banerjee
High-intensity focused ultrasound (HIFU) has gained increasing popularity as a noninvasive therapeutic procedure to treat solid tumors. However, collateral damage due to the use of high acoustic powers during HIFU procedures remains a challenge. The objective of this study is to assess the utility of using gold nanoparticles (gNPs) during HIFU procedures to locally enhance heating at low powers, thereby reducing the likelihood of collateral damage. Phantoms containing tissue-mimicking material (TMM) and physiologically relevant concentrations (0%, 0...
March 16, 2017: Nano Letters
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