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https://www.readbyqxmd.com/read/29773767/the-role-of-brincidofovir-in-preparation-for-a-potential-smallpox-outbreak
#1
Scott A Foster, Scott Parker, Randall Lanier
Smallpox (variola) virus is considered a Category A bioterrorism agent due to its ability to spread rapidly and the high morbidity and mortality rates associated with infection. Current recommendations recognize the importance of oral antivirals and call for having at least two smallpox antivirals with different mechanisms of action available in the event of a smallpox outbreak. Multiple antivirals are recommended due in large part to the propensity of viruses to become resistant to antiviral therapy, especially monotherapy...
October 30, 2017: Viruses
https://www.readbyqxmd.com/read/29745484/-transition-from-postgraduate-training-to-independent-practice-can-we-do-better
#2
Noëlle Junod Perron, Cédric Lanier, Sanae Mazouri
Transition from postgraduate training to independent practice in primary care can be experienced as very stressful. This may be partly explained by the fact that in Switzerland, only six months training in ambulatory medicine are required as part of a five year training for the title of primary care physician. This seems largely insufficient given the diversity of tasks and skills to master. This article aims to make junior doctors aware of the medical and non medical skills they should acquire before entering in primary care independent practice (practice management, insurance, medico-legal issues)...
May 9, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29740743/initial-brain-metastasis-velocity-does-the-rate-at-which-cancers-first-seed-the-brain-affect-outcomes
#3
Michael H Soike, Emory R McTyre, Ryan T Hughes, Michael Farris, Christina K Cramer, Michael C LeCompte, Claire M Lanier, Jimmy Ruiz, Jing Su, Kounosuke Watabe, J Daniel Bourland, Michael T Munley, Stacey O'Neill, Adrian W Laxton, Stephen B Tatter, Michael D Chan
PURPOSE/OBJECTIVE(S): Brain metastasis velocity (BMV) is a metric that describes the rate of development of new brain metastases (BM) after initial stereotactic radiosurgery (SRS). A limitation in the application of BMV is it cannot be applied until time of first BM failure after SRS. We developed initial BM velocity (iBMV), a new metric that accounts for the number of BM at first SRS and the time since initial cancer diagnosis. MATERIALS/METHODS: We reviewed patients with BM treated at our institution with upfront SRS without WBRT...
May 8, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29695498/validation-of-the-anca-associated-vasculitis-patient-reported-outcomes-aav-pro-questionnaire
#4
Joanna Robson, Jill Dawson, Helen Doll, Peter F Cronholm, Nataliya Milman, Katherine Kellom, Susan Ashdown, Ebony Easley, Don Gebhart, Georgia Lanier, John Mills, Jacqueline Peck, Raashid Ahmed Luqmani, Judy Shea, Gunnar Tomasson, Peter Merkel
ObjectivesTo finalise and validate a disease-specific patient-reported outcome (PRO) measure: the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) questionnaire. Using a 35-item candidate questionnaire developed following 50 qualitative interviews in the UK, USA and Canada, a longitudinal survey was conducted to determine the final scale structure and validate the AAV-PRO. METHODS: Participants were recruited via Vasculitis UK and the Vasculitis Patient-Powered Research Network...
April 25, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29660077/immediate-effects-of-a-single-session-of-motor-skill-training-on-the-lumbar-movement-pattern-during-a-functional-activity-in-people-with-low-back-pain-a-repeated-measures-study
#5
Andrej V Marich, Vanessa M Lanier, Gretchen B Salsich, Catherine E Lang, Linda R Van Dillen
Background: People with low back pain (LBP) may display an altered lumbar movement pattern of early lumbar motion compared to people with healthy backs. Modifying this movement pattern during a clinical test decreases pain. It is unknown whether similar effects would be seen during a functional activity. Objective: The objective of this study is was to examine the lumbar movement patterns before and after motor skill training, effects on pain, and characteristics that influenced the ability to modify movement patterns...
April 6, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29644888/motor-skill-training-in-musculoskeletal-pain-a-case-report-in-chronic-low-back-pain
#6
Vanessa M Lanier, Catherine E Lang, Linda R Van Dillen
PURPOSE: Low back pain is a chronic condition that limits function. The chief reason individuals with low back pain seek care is difficulty performing functional activities. A novel approach to improving performance of painful and limited functional activities is motor skill training, defined as challenging practice of activities to learn or relearn a skill. The purpose of this report is to describe the design and application of a motor skill training intervention in a 26-year-old man with a 10-year history of low back pain...
April 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29618525/crk-adaptor-proteins-regulate-nk-cell-expansion-and-differentiation-during-mouse-cytomegalovirus-infection
#7
Tsukasa Nabekura, Zhiying Chen, Casey Schroeder, Taeju Park, Eric Vivier, Lewis L Lanier, Dongfang Liu
Natural killer cells are critical in the immune response to infection and malignancy. Prior studies have demonstrated that Crk family proteins can influence cell apoptosis, proliferation, and cell transformation. In this study, we investigated the role of Crk family proteins in mouse NK cell differentiation and host defense using a mouse CMV infection model. The number of NK cells, maturational state, and the majority of the NKR repertoire was similar in Crk x Crk-like (CrkL)-double-deficient and wild type NK cells...
May 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29608499/diagnosis-treatment-and-management-of-orthotopic-liver-transplant-candidates-with-portopulmonary-hypertension
#8
Anna Koulava, Abdallah Sannani, Avi Levine, Chhaya Aggarwal Gupta, Sarina Khanal, William Frishman, Roxana Bodin, David C Wolf, William Aronow, Gregg M Lanier
Portopulmonary hypertension (POPH) is seen in 5-8% of orthotopic liver transplantation (OLT) candidates and has significant implications for clinical outcomes. POPH is characterized by vasoconstriction and remodeling of the pulmonary vasculature. It is exacerbated by the hyperdynamic circulation that is common in advanced liver disease. Screening all OLT candidates with transthoracic echocardiography to assess pulmonary pressures and right ventricular function is crucial, as clinical symptoms alone are not reliable...
March 30, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29599226/natural-killers-join-the-fight-against-cancer
#9
COMMENT
Adelheid Cerwenka, Lewis L Lanier
No abstract text is available yet for this article.
March 30, 2018: Science
https://www.readbyqxmd.com/read/29581520/predicting-urban-reservoir-levels-using-statistical-learning-techniques
#10
Renee Obringer, Roshanak Nateghi
Urban water supplies are critical to the growth of the city and the wellbeing of its citizens. However, these supplies can be vulnerable to hydrological extremes, such as droughts and floods, especially if they are the main source of water for the city. Maintaining these supplies and preparing for future conditions is a crucial task for water managers, but predicting hydrological extremes is a challenge. This study tested the abilities of eight statistical learning techniques to predict reservoir levels, given the current hydroclimatic conditions, and provide inferences on the key predictors of reservoir levels...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29569143/a-framework-for-culturally-relevant-online-learning-lessons-from-alaska-s-tribal-health-workers
#11
Katie Cueva, Melany Cueva, Laura Revels, Anne P Lanier, Mark Dignan, K Viswanath, Teresa T Fung, Alan C Geller
Culturally relevant health promotion is an opportunity to reduce health inequities in diseases with modifiable risks, such as cancer. Alaska Native people bear a disproportionate cancer burden, and Alaska's rural tribal health workers consequently requested cancer education accessible online. In response, the Alaska Native Tribal Health Consortium cancer education team sought to create a framework for culturally relevant online learning to inform the creation of distance-delivered cancer education. Guided by the principles of community-based participatory action research and grounded in empowerment theory, the project team conducted a focus group with 10 Alaska Native education experts, 12 culturally diverse key informant interviews, a key stakeholder survey of 62 Alaska Native tribal health workers and their instructors/supervisors, and a literature review on distance-delivered education with Alaska Native or American Indian people...
March 22, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29555676/pillars-article-activation-of-nk-cells-and-t-cells-by-nkg2d-a-receptor-for-stress-inducible-mica-science-1999-285-727-729
#12
Stefan Bauer, Veronika Groh, Jun Wu, Alexander Steinle, Joseph H Phillips, Lewis L Lanier, Thomas Spies
No abstract text is available yet for this article.
April 1, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29521890/neuroanesthesiology-update
#13
Jeffrey J Pasternak, William L Lanier
We provide a synopsis of innovative research, recurring themes, and novel experimental findings pertinent to the care of neurosurgical patients and critically ill patients with neurological diseases. We cover the following broad topics: general neurosurgery, spine surgery, stroke, traumatic brain injury, monitoring, and anesthetic neurotoxicity.
April 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29521193/reporting-maltreatment-to-child-protective-services-in-the-context-of-intimate-partner-violence-research
#14
Cynthia Fraga Rizo, Jennifer O'Brien, Rebecca Macy, Dania Ermentrout, Paul Lanier
Given the overlap between intimate partner violence (IPV) and child maltreatment, IPV-exposed child participants in research might disclose instances of child maltreatment. Such disclosures might require researchers to report the maltreatment to child protective services (CPS). However, the literature provides minimal guidance on how to navigate the complex challenges and ethical dilemmas around reporting in the context of research. To help address this gap and stimulate discussion regarding protocols and policies for reporting child maltreatment, this article presents a CPS reporting protocol developed as part of a community-engaged research project evaluating a parenting intervention for system-involved mothers experiencing IPV...
March 1, 2018: Violence Against Women
https://www.readbyqxmd.com/read/29507584/clinical-implications-of-cd4-t-cell-subsets-in-adult-atopic-asthma-patients
#15
Matthew Wiest, Katherine Upchurch, Wenjie Yin, Jerome Ellis, Yaming Xue, Bobby Lanier, Mark Millard, HyeMee Joo, SangKon Oh
Background: T cells play a central role in chronic inflammation in asthma. However, the roles of individual subsets of T cells in the pathology of asthma in patients remain to be better understood. Methods: We investigated the potential signatures of T cell subset phenotypes in asthma using fresh whole blood from adult atopic asthma patients (n = 43) and non-asthmatic control subjects (n = 22). We further assessed their potential clinical implications by correlating asthma severity...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29504171/evaluation-of-noncontrast-mr-enterography-for-pediatric-inflammatory-bowel-disease-assessment
#16
Michael Hunter Lanier, Anup S Shetty, Amber Salter, Geetika Khanna
BACKGROUND: Gadolinium deposition in normal tissues is being increasingly recognized. Children with inflammatory bowel disease (IBD) undergo frequent imaging with contrast-enhanced MR enterography (MRE). PURPOSE: To determine the impact of intravenous (IV) gadolinium in assessment of pediatric IBD by MRE. STUDY TYPE: Retrospective, case series. POPULATION: Radiology information system was searched to identify all children who underwent MRE and endoscopy within 30 days in 2016...
March 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29481391/intraoperative-nerve-blocks-fail-to-improve-quality-of-recovery-after-tissue-expander-breast-reconstruction-a-prospective-double-blinded-randomized-placebo-controlled-clinical-trial
#17
Steven T Lanier, Kevin C Lewis, Mark C Kendall, Brittany L Vieira, Gildasio De Oliveira, Anthony Nader, John Y S Kim, Mohammed Alghoul
BACKGROUND: The authors' study represents the first level I evidence to assess whether intraoperative nerve blocks improve the quality of recovery from immediate tissue expander/implant breast reconstruction. METHODS: A prospective, randomized, double-blinded, placebo-controlled clinical trial was conducted in which patients undergoing immediate tissue expander/implant breast reconstruction were randomized to either (1) intraoperative intercostal and pectoral nerve blocks with 0...
March 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29463158/the-nature-magnitude-and-reporting-compliance-of-device-related-events-for-intravenous-patient-controlled-analgesia-in-the-fda-manufacturer-and-user-facility-device-experience-maude-database
#18
Oluwadolapo D Lawal, Maitreyee Mohanty, Harrison Elder, Margie Skeer, Nathalie Erpelding, Ryan Lanier, Nathaniel Katz
BACKGROUND: The aim of this study is to determine the characteristics, magnitude, and the quality of reporting of mandated events involving intravenous patient-controlled analgesia (IV-PCA) devices in the Food and Drug Administration (FDA) Manufacturer and User Facility Device Experience (MAUDE) database; a postmarket surveillance system. METHODS: We utilized a mixed-methods approach to systematically characterize structured data and text narratives associated with IV-PCA events submitted to MAUDE between 1 January 2011 and 12 September 2016...
April 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29445835/application-and-evaluation-of-a-high-resolution-mass-spectrometry-screening-method-for-veterinary-drug-residues-in-incurred-fish-and-imported-aquaculture-samples
#19
Sherri B Turnipseed, Joseph M Storey, I-Lin Wu, Charles M Gieseker, Nicholas R Hasbrouck, Tina C Crosby, Wendy C Andersen, Shanae Lanier, Christine R Casey, Robert Burger, Mark R Madson
The ability to detect chemical contaminants, including veterinary drug residues in animal products such as fish, is an important example of food safety analysis. In this paper, a liquid chromatography high-resolution mass spectrometry (LC-HRMS) screening method using a quadrupole-Orbitrap instrument was applied to the analysis of veterinary drug residues in incurred tissues from aquacultured channel catfish, rainbow trout, and Atlantic salmon and imported aquacultured products including European eel, yellow croaker, and tilapia...
February 14, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29439613/occurrence-of-endocrine-and-thyroid-cancers-among-alaska-native-people-1969-2013
#20
Sarah H Nash, Anne P Lanier, Molly B Southworth
BACKGROUND: Nationwide, the incidence of thyroid cancer is lower among American Indian/Alaska Native (AI/AN) people than among U.S. whites (USW). However, little is known about the incidence of thyroid or other endocrine cancers specifically among Alaska Native (AN) people. METHODS: Data were examined from the National Cancer Institute's Surveillance, Epidemiology, and End Results Alaska Native Tumor Registry on endocrine cancers diagnosed among AN people from 1969-2013, with a specific focus on thyroid cancers...
April 2018: Thyroid: Official Journal of the American Thyroid Association
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