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https://www.readbyqxmd.com/read/27910498/using-visar-to-assess-the-m-band-isotropy-in-hohlraums
#1
N E Lanier, J L Kline, J Morton
In laser based radiation flow experiments, drive variability can often overwhelm the physics sensitivity that one seeks to quantify. Hohlraums can help by providing a more symmetrized, Planckian-like source. However, at higher temperatures, the hohlraum's actual emission can deviate significantly from a truly blackbody, Lambertian source. At the National Ignition Facility (NIF), Dante provides the best quantification of hohlraum output. Unfortunately, limited diagnostic access coupled with NIF's natural symmetry does not allow for Dante measurements at more than two angles...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910339/atomic-physics-modeling-of-transmission-spectra-of-sc-doped-aerogel-foams-to-support-omega-experiments
#2
H M Johns, N E Lanier, J L Kline, C J Fontes, T S Perry, C L Fryer, C R D Brown, J W Morton, J D Hager, M E Sherrill
We present synthetic transmission spectra generated with PrismSPECT utilizing both the ATBASE model and the Los Alamos opacity library (OPLIB) to evaluate whether an alternative choice in atomic data will impact modeling of experimental data from radiation transport experiments using Sc-doped aerogel foams (ScSi6O12 at 75 mg/cm(3) density). We have determined that in the 50-200 eV Te range there is a significant difference in the 1s-3p spectra, especially below 100 eV, and for Te = 200 eV above 5000 eV in photon energy...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27810928/tracking-the-fate-of-antigen-specific-versus-cytokine-activated-natural-killer-cells-after-cytomegalovirus-infection
#3
Tsukasa Nabekura, Lewis L Lanier
Natural killer (NK) cells provide important host defense and can generate long-lived memory NK cells. Here, by using novel transgenic mice carrying inducible Cre expressed under the control of Ncr1 gene, we demonstrated that two distinct long-lived NK cell subsets differentiate in a mouse model of cytomegalovirus (MCMV) infection. NK cells expressing the MCMV-specific Ly49H receptor differentiated into memory NK cells by an activating signaling through Ly49H and Ly49H(-) NK cells differentiated into cytokine-activated NK cells by exposure to inflammatory cytokines during infection...
November 14, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27787875/posterior-fossa-syndrome-review-of-the-behavioral-and-emotional-aspects-in-pediatric-cancer-patients
#4
REVIEW
Jane C Lanier, Annah N Abrams
Medulloblastoma, the most common malignant brain tumor of childhood, occurs in the posterior fossa, the part of the intracranial cavity that contains the brainstem and the cerebellum. The cerebellum is involved in many complex aspects of human behavior and function, and when it is disrupted or insulted, this can lead to significant sequelae in children with posterior fossa tumors. A constellation of impairing and distressing symptoms, including mutism, ataxia/hypotonia, and emotional lability, develops in approximately 25% of children after the surgical resection of posterior fossa tumors...
October 27, 2016: Cancer
https://www.readbyqxmd.com/read/27780238/bacterial-etiology-and-risk-factors-associated-with-cellulitis-and-purulent-skin-abscesses-in-military-trainees
#5
Ryan C Johnson, Michael W Ellis, Carey D Schlett, Eugene V Millar, Patrick T LaBreck, Deepika Mor, Emad M Elassal, Jeffrey B Lanier, Cassie L Redden, Tianyuan Cui, Nimfa Teneza-Mora, Danett K Bishop, Eric R Hall, Kimberly A Bishop-Lilly, D Scott Merrell
: Military trainees are at high risk for skin and soft-tissue infections (SSTIs). Although Staphylococcus aureus is associated with purulent SSTI, it is unclear to what degree this pathogen causes nonpurulent cellulitis. To inform effective prevention strategies and to provide novel insights into SSTI pathogenesis, we aimed to determine the etiology of SSTI in this population. We conducted a prospective observational study in US Army Infantry trainees with SSTI (cutaneous abscesses and cellulitis) from July 2012 through December 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27757361/mesh-sutured-repairs-of-abdominal-wall-defects
#6
Steven T Lanier, Gregory A Dumanian, Sumanas W Jordan, Kyle R Miller, Nada A Ali, Stuart R Stock
: A new closure technique is introduced, which uses strips of macroporous polypropylene mesh as a suture for closure of abdominal wall defects due to failures of standard sutures and difficulties with planar meshes. METHODS: Strips of macroporous polypropylene mesh of 2 cm width were passed through the abdominal wall and tied as simple interrupted sutures. The surgical technique and surgical outcomes are presented. RESULTS: One hundred and seven patients underwent a mesh sutured abdominal wall closure...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27757332/the-northwestern-abdominoplasty-scar-model-a-novel-human-model-for-scar-research-and-therapeutics
#7
Steven T Lanier, Jing Liu, Claudia Chavez-Munoz, Thomas A Mustoe, Robert D Galiano
There is a growing interest in the development and evaluation of therapeutic agents that improve the cosmetic appearance of scars. Existing nonhuman animal models to study scarring, while valuable, have well-acknowledged limitations, as it is accepted that the biology of human scarring differs significantly from scarring in other species. Moreover, human clinical trials of scarring require large numbers of subjects to achieve statistical power and are plagued by inherent intersubject variability because of the complex nature of wound healing in human beings...
September 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27747300/multi-body-site-microbiome-and-culture-profiling-of-military-trainees-suffering-from-skin-and-soft-tissue-infections-at-fort-benning-georgia
#8
Jatinder Singh, Ryan C Johnson, Carey D Schlett, Emad M Elassal, Katrina B Crawford, Deepika Mor, Jeffrey B Lanier, Natasha N Law, William A Walters, Nimfa Teneza-Mora, Jason W Bennett, Eric R Hall, Eugene V Millar, Michael W Ellis, D Scott Merrell
Skin and soft tissue infections (SSTIs) are common in the general population, with increased prevalence among military trainees. Previous research has revealed numerous nasal microbial signatures that correlate with SSTI development and Staphylococcus aureus colonization. Thus, we hypothesized that the ecology of the inguinal, oropharynx, and perianal regions may also be altered in response to SSTI and/or S. aureus colonization. We collected body site samples from 46 military trainees with purulent abscess (SSTI group) as well as from 66 asymptomatic controls (non-SSTI group)...
September 2016: MSphere
https://www.readbyqxmd.com/read/27714078/advances-in-the-synthesis-of-glycosidic-macrolides-clavosolides-a-d-and-cyanolide-a
#9
Kiyoun Lee, Megan L Lanier, Jae-Hwan Kwak, Hyoungsu Kim, Jiyong Hong
Covering: 2005 to 2016Clavosolides A-D and cyanolide A are glycosidic macrolides and represent a new family of marine natural products. They possess a number of unusual structural features and have attracted considerable interest from the synthetic community. This review presents a comprehensive survey of all aspects of the clavosolides A-D and cyanolide A. Specific topics include isolation, structure determination, biological activity, and synthetic approaches.
September 12, 2016: Natural Product Reports
https://www.readbyqxmd.com/read/27669335/iron-deficiency-impairs-developing-hippocampal-neuron-gene-expression-energy-metabolism-and-dendrite-complexity
#10
Thomas W Bastian, William C von Hohenberg, Daniel J Mickelson, Lorene M Lanier, Michael K Georgieff
Iron deficiency (ID), with and without anemia, affects an estimated 2 billion people worldwide. ID is particularly deleterious during early-life brain development, leading to long-term neurological impairments including deficits in hippocampus-mediated learning and memory. Neonatal rats with fetal/neonatal ID anemia (IDA) have shorter hippocampal CA1 apical dendrites with disorganized branching. ID-induced dendritic structural abnormalities persist into adulthood despite normalization of the iron status. However, the specific developmental effects of neuronal iron loss on hippocampal neuron dendrite growth and branching are unknown...
2016: Developmental Neuroscience
https://www.readbyqxmd.com/read/27590851/leptin-induced-transphosphorylation-of-vascular-endothelial-growth-factor-receptor-increases-notch-and-stimulates-endothelial-cell-angiogenic-transformation
#11
Viola Lanier, Corey Gillespie, Merle Leffers, Danielle Daley-Brown, Joy Milner, Crystal Lipsey, Nia Webb, Leonard M Anderson, Gale Newman, Johannes Waltenberger, Ruben Rene Gonzalez-Perez
Leptin increases vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2), and Notch expression in cancer cells, and transphosphorylates VEGFR-2 in endothelial cells. However, the mechanisms involved in leptin's actions in endothelial cells are not completely known. Here we investigated whether a leptin-VEGFR-Notch axis is involved in these leptin's actions. To this end, human umbilical vein and porcine aortic endothelial cells (wild type and genetically modified to overexpress VEGFR-1 or -2) were cultured in the absence of VEGF and treated with leptin and inhibitors of Notch (gamma-secretase inhibitors: DAPT and S2188, and silencing RNA), VEGFR (kinase inhibitor: SU5416, and silencing RNA) and leptin receptor, OB-R (pegylated leptin peptide receptor antagonist 2: PEG-LPrA2)...
October 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27579958/patient-and-caregiver-perspectives-of-preoperative-teaching-for-deep-brain-stimulation-surgery
#12
Elaine M Lanier-Bohan, Susan L Heath
Deep brain stimulation (DBS) has developed into an important therapy for Parkinson disease, essential tremor, and dystonia with more nurses in varied settings often preparing patients and families for this type of surgery. This exploratory study sought to obtain patient and caregiver perspectives of the current DBS teaching for Parkinson disease, essential tremor, and dystonia; to improve the teaching; and to standardize the education. Using survey methodology, 41 patients with movement disorder and 32 caregivers completed surveys about the preoperative instructions they received...
October 2016: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/27545993/reliable-complex-abdominal-wall-hernia-repairs-with-a-narrow-well-fixed-retrorectus-polypropylene-mesh-a-review-of-over-100-consecutive-cases
#13
Steven T Lanier, Jennifer E Fligor, Kyle R Miller, Gregory A Dumanian
BACKGROUND: Our objective was to determine outcomes for complex ventral hernia repairs in a large cohort of patients utilizing an operative construct employing retrorectus placement of a narrow, macroporous polypropylene mesh with up to 45 suture fixation points for force distribution. No consensus exists on the optimal technique for repair of complex ventral hernias. Current trends emphasize large meshes with wide overlaps and minimal suture fixation, though reported complications and recurrence remain problematic...
December 2016: Surgery
https://www.readbyqxmd.com/read/27519261/development-of-a-barbershop-based-hiv-sti-risk-reduction-intervention-for-young-heterosexual-african-american-men
#14
Loretta Sweet Jemmott, John B Jemmott, Yzette Lanier, Ciarra Thompson, Jillian Lucas Baker
Young, heterosexual African American men ages 18 to 24 years continue to be at high risk for HIV and other sexually transmitted infections. However, few interventions have been designed to meet the needs of this "forgotten" population. The article describes the systematic development of a theory-based, culturally-tailored, gender-specific, barbershop-based HIV risk reduction intervention for heterosexual African American men ages 18 to 24. The process included developing a community advisory board, selecting a guiding theoretical framework, incorporating community-based participatory research principles, and conducting formative research with African American males, barbers, and barbershop owners...
August 12, 2016: Health Promotion Practice
https://www.readbyqxmd.com/read/27517755/michael-m-todd-m-d-recipient-of-the-2016-excellence-in-research-award
#15
David S Warner, William L Lanier
No abstract text is available yet for this article.
August 8, 2016: Anesthesiology
https://www.readbyqxmd.com/read/27507246/tyrosine-kinase-inhibition-reverses-tdp-43-effects-on-synaptic-protein-expression-astrocytic-function-and-amino-acid-dis-homeostasis
#16
Lanier Heyburn, Michaeline L Hebron, Jacqueline Smith, Charisse Winston, John Bechara, Zhaoxia Li, Irina Lonskaya, Mark P Burns, Brent T Harris, Charbel E-H Moussa
The trans-activating response of DNA/RNA-binding protein (TDP)-43 pathology is associated with many neurodegenerative diseases via unknown mechanisms. Here, we use a transgenic mouse model over-expressing human wild-type neuronal TDP-43 to study the effects of TDP-43 pathology on glutamate metabolism and synaptic function. We found that neuronal TDP-43 over-expression affects synaptic protein expression, including Synapsin I, and alters surrounding astrocytic function. TDP-43 over-expression is associated with an increase in glutamate and γ-amino butyric acid and reduction of glutamine and aspartate levels, indicating impairment of presynaptic terminal...
November 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27463336/identification-of-a-monoclonal-antibody-that-attenuates-antiphospholipid-syndrome-related-pregnancy-complications-and-thrombosis
#17
Chieko Mineo, Lane Lanier, Eunjeong Jung, Samarpita Sengupta, Victoria Ulrich, Anastasia Sacharidou, Cristina Tarango, Olutoye Osunbunmi, Yu-Min Shen, Jane E Salmon, Rolf A Brekken, Xianming Huang, Philip E Thorpe, Philip W Shaul
In the antiphospholipid syndrome (APS), patients produce antiphospholipid antibodies (aPL) that promote thrombosis and adverse pregnancy outcomes. Current therapy with anticoagulation is only partially effective and associated with multiple complications. We previously discovered that aPL recognition of cell surface β2-glycoprotein I (β2-GPI) initiates apolipoprotein E receptor 2 (apoER2)-dependent signaling in endothelial cells and in placental trophoblasts that ultimately promotes thrombosis and fetal loss, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27458288/phase-ib-study-of-selinexor-a-first-in-class-inhibitor-of-nuclear-export-in-patients-with-advanced-refractory-bone-or-soft-tissue-sarcoma
#18
Mrinal M Gounder, Alona Zer, William D Tap, Samer Salah, Mark A Dickson, Abha A Gupta, Mary Louise Keohan, Herbert H Loong, Sandra P D'Angelo, Stephanie Baker, Mercedes Condy, Kjirsten Nyquist-Schultz, Lanier Tanner, Joseph P Erinjeri, Francis H Jasmine, Sharon Friedlander, Robert Carlson, Thaddeus J Unger, Jean-Richard Saint-Martin, Tami Rashal, Joel Ellis, Michael Kauffman, Sharon Shacham, Gary K Schwartz, Albiruni Ryan Abdul Razak
PURPOSE: We evaluated the pharmacokinetics (PKs), pharmacodynamics, safety, and efficacy of selinexor, an oral selective inhibitor of nuclear export compound, in patients with advanced soft tissue or bone sarcoma with progressive disease. PATIENTS AND METHODS: Fifty-four patients were treated with oral selinexor twice per week (on days 1 and 3) at one of three doses (30 mg/m(2), 50 mg/m(2), or flat dose of 60 mg) either continuously or on a schedule of 3 weeks on, 1 week off...
September 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27438766/activating-receptors-for-self-mhc-class-i-enhance-effector-functions-and-memory-differentiation-of-nk-cells-during-mouse-cytomegalovirus-infection
#19
Tsukasa Nabekura, Lewis L Lanier
Natural killer (NK) cells are important in host defense against pathogens, and they can subsequently differentiate into memory NK cells. The Ly49 and KIR gene families in rodents and humans encode both inhibitory and activating receptors for MHC class I. The physiological role of activating KIR or Ly49 receptors that recognize self-MHC class I during immune response to viral infections is unknown. Here, we address how the activating Ly49D receptor impacts the NK cell response to mouse cytomegalovirus (MCMV) infection by comparing the activation and differentiation of Ly49D-bearing NK cells in mice lacking or expressing H-2D(d), the cognate MHC class I ligand of Ly49D...
July 19, 2016: Immunity
https://www.readbyqxmd.com/read/27429956/promoting-culturally-respectful-cancer-education-through-digital-storytelling
#20
Melany Cueva, Regina Kuhnley, Anne Lanier, Mark Dignan, Laura Revels, Nancy E Schoenberg, Katie Cueva
Cancer is the leading cause of mortality among Alaska Native people. Over half of Alaska Native people live in rural communities where specially trained community members called Community Health Aides/Practitioners (CHA/Ps) provide health care. In response to CHA/Ps' expressed desire to learn more about cancer, four 5-day cancer education and digital storytelling courses were provided in 2014. Throughout each course, participants explored cancer information, reflected on their personal experiences, and envisioned how they might apply their knowledge within their communities...
2016: International Journal of Indigenous Health
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