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Tick borne-encephalitis virus

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https://www.readbyqxmd.com/read/29678403/tick-borne-encephalitis-virus-borrelia-burgdorferi-sensu-lato-borrelia-miyamotoi-anaplasma-phagocytophilum-and-candidatus-neoehrlichia-mikurensis-in-ixodes-ricinus-ticks-collected-from-recreational-islands-in-southern-norway
#1
Vivian Kjelland, Katrine M Paulsen, Rikke Rollum, Andrew Jenkins, Snorre Stuen, Arnulf Soleng, Kristin S Edgar, Heidi H Lindstedt, Kirsti Vaino, Moustafa Gibory, Åshild K Andreassen
The aim of this study was to determine the occurrence of tick-borne pathogens of medical importance in questing ticks collected from five recreationally used islands along the Norwegian coastline. Furthermore, since coinfection may affect the disease severity, this study aimed to determine the extent of coinfection in individual ticks or co-localization of tick-borne pathogens. In all, 4158 questing Ixodes ricinus ticks were analyzed. For detection of tick-borne encephalitis virus (TBEV), nymphs (3690) were analyzed in pools of ten...
April 12, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29678401/geographical-distribution-climate-adaptation-and-vector-competence-of-the-eurasian-hard-tick-haemaphysalis-concinna
#2
Franz Rubel, Katharina Brugger, Melanie Walter, Janna R Vogelgesang, Yuliya M Didyk, Su Fu, Olaf Kahl
The ixodid tick Haemaphysalis concinna Koch, 1844 is a proven vector of tick-borne encephalitis (TBE) virus and Francisella tularensis, the causative agent of tularaemia. In the present study, up-to-date maps depicting the geographical distribution and climate adaptation of H. concinna are presented. A dataset was compiled, resulting in 656 georeferenced locations in Eurasia. The distribution of H. concinna ranges from the Spanish Atlantic coast to Kamchatka, Russia, within the belt of 28-64° N latitude...
April 10, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29669948/survey-of-tick-borne-zoonotic-viruses-in-wild-deer-in-hokkaido-japan
#3
Leo Uchida, Daisuke Hayasaka, Mya Myat Ngwe Tun, Kouichi Morita, Yasukazu Muramatsu, Katsuro Hagiwara
Tick-borne encephalitis (TBE) and severe fever with thrombocytopenia syndrome (SFTS) are both tick-borne zoonotic diseases caused by TBE virus (TBEV) and SFTS phlebovirus (SFTSV). In 2016, a second domestic TBE case was reported in Hokkaido, Japan, after an absence of 23 years. We conducted IgG ELISA for TBEV and SFTSV on 314 deer (Cervus nippon yesoensis) serum samples collected from 3 places in Hokkaido. There were 7 seropositive samples for TBEV but none for SFTSV by ELISA. The specificity of the 7 positive samples was confirmed by neutralization tests against TBEV, and 5 sera showed 320 to 640 of 50% focus reduction endpoint titers...
April 19, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29667575/a-cluster-of-two-human-cases-of-tick-borne-encephalitis-tbe-transmitted-by-unpasteurised-goat-milk-and-cheese-in-germany-may-2016
#4
S O Brockmann, R Oehme, T Buckenmaier, M Beer, A Jeffery-Smith, M Spannenkrebs, S Haag-Milz, C Wagner-Wiening, C Schlegel, J Fritz, S Zange, M Bestehorn, A Lindau, D Hoffmann, S Tiberi, U Mackenstedt, G Dobler
In May 2016, two cases of tick-borne encephalitis (TBE) were confirmed by serology (positive IgM and IgG antibodies against TBE virus (TBEV) in serum), with a possible link to raw milk and cheese from a goat farm in a region in Baden-Württemberg, Germany not previously known as TBE-endemic. The outbreak investigation identified 32 consumers of goat dairy products (29 consumers, one farm employee, two owners) of whom none had IgM antibodies against TBEV 3-8 weeks after consumption. Of the 27 notified TBE cases in the State, none reported consumption of raw goat milk or cheese from the suspected farm...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29664395/fatal-tick-borne-encephalitis-virus-infections-caused-by-siberian-and-european-subtypes-finland-2015
#5
Suvi Kuivanen, Teemu Smura, Kirsi Rantanen, Leena Kämppi, Jonas Kantonen, Mia Kero, Anu Jääskeläinen, Anne J Jääskeläinen, Jussi Sane, Liisa Myllykangas, Anders Paetau, Olli Vapalahti
In most locations except for Russia, tick-borne encephalitis is mainly caused by the European virus subtype. In 2015, fatal infections caused by European and Siberian tick-borne encephalitis virus subtypes in the same Ixodes ricinus tick focus in Finland raised concern over further spread of the Siberian subtype among widespread tick species.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29655579/hungarian-tick-borne-encephalitis-viruses-isolated-from-a-0-5-ha-focus-are-closely-related-to-finnish-strains
#6
László Egyed, Zsuzsanna Rónai, Ádám Dán
Four tick-borne encephalitis virus strains were isolated from a small 0.5-ha focus over a six-year-long period (2011-2016) in Hungary. Two strains with identical genomes were isolated from Ixodes ricinus and Haemaphysalis concinna two months apart, which shows that the virus had not evolved separately in these tick species. Whole-genome sequencing of the virus revealed that the isolates differed from each other in 4 amino acids and 9 nucleotides. The calculated substitution rates indicated that the speed of genome evolution differs from habitat to habitat, and continuously changes even within the same focus...
April 7, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29652642/powassan-virus-disease-in-the-united-states-2006-2016
#7
Elisabeth R Krow-Lucal, Nicole P Lindsey, Marc Fischer, Susan L Hills
BACKGROUND: Powassan virus (POWV) is a tick-borne flavivirus that causes rare, but often severe, disease in humans. POWV neuroinvasive disease was added to the U.S. nationally notifiable disease list in 2001 and nonneuroinvasive disease was added in 2004. The only previous review of the epidemiology of POWV disease in the United States based on cases reported to the Centers for Disease Control and Prevention (CDC) covered the period from 1999 through 2005. METHODS: We describe the epidemiology and clinical features of laboratory-confirmed POWV disease cases reported to CDC from 2006 through 2016...
March 13, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29652486/biochemistry-and-molecular-biology-of-flaviviruses
#8
Nicholas J Barrows, Rafael K Campos, Kuo-Chieh Liao, K Reddisiva Prasanth, Ruben Soto-Acosta, Shih-Chia Yeh, Geraldine Schott-Lerner, Julien Pompon, October M Sessions, Shelton S Bradrick, Mariano A Garcia-Blanco
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year. Most of these pathogens are transmitted by mosquitos, and not surprisingly, as the earth warms and human populations grow and move, their geographic reach is increasing. Flaviviruses are simple RNA-protein machines that carry out protein synthesis, genome replication, and virion packaging in close association with cellular lipid membranes...
April 13, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29642580/arbidol-umifenovir-a-broad-spectrum-antiviral-drug-that-inhibits-medically-important-arthropod-borne-flaviviruses
#9
Jan Haviernik, Michal Štefánik, Martina Fojtíková, Sabrina Kali, Noël Tordo, Ivo Rudolf, Zdeněk Hubálek, Luděk Eyer, Daniel Ruzek
Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compound shows activities against numerous DNA and RNA viruses. The mode of action is based predominantly on impairment of critical steps in virus-cell interactions. Here we demonstrate that arbidol possesses micromolar-level anti-viral effects (EC50 values ranging from 10...
April 10, 2018: Viruses
https://www.readbyqxmd.com/read/29623261/increased-relative-risk-of-tick-borne-encephalitis-in-warmer-weather
#10
Milan Daniel, Vlasta Danielová, Alena Fialová, Marek Malý, Bohumír Kříž, Patricia A Nuttall
Tick-borne encephalitis (TBE) is a serious acute neuroinfection of humans caused by a tick-borne flavivirus. The disease is typically seasonal, linked to the host-seeking activity of Ixodes ricinus (predominantly nymphs), the principal European tick vector species. To address the need for accurate risk predictions of contracting TBE, data on 4,044 TBE cases reported in the Czech Republic during 2001-2006 were compared with questing activity of I. ricinus nymphs monitored weekly at a defined location for the same 6-year period...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29610047/comparison-of-three-commercial-igg-and-igm-elisa-kits-for-the-detection-of-tick-borne-encephalitis-virus-antibodies
#11
Rahel Ackermann-Gäumann, Marie-Lise Tritten, Mona Hassan, Reto Lienhard
Tick-borne encephalitis (TBE) is endemic in many parts of Europe and Asia. The diagnosis of this disease is essentially based on the demonstration of specific antibodies. For reasons of simplicity, automatization and quick availability of test results, enzyme-linked immunosorbent assays (ELISAs) are the method of choice for serological diagnosis of TBE. Here, we evaluated three commercially available anti-TBEV IgG and IgM ELISAs using 251 serum samples: the SERION ELISA classic FSME Virus/TBE Virus IgG and IgM kit (Virion\Serion), the RIDASCREEN® FSME/TBE IgG and IgM kit (R-Biopharm), and the anti-FSME/TBE virus ELISA "Vienna" IgG/anti-FSME/TBE virus ELISA IgM kit (Euroimmun)...
March 28, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29602685/intrathecal-expression-of-il-5-and-humoral-response-in-patients-with-tick-borne-encephalitis
#12
Sambor Grygorczuk, Piotr Czupryna, Sławomir Pancewicz, Renata Świerzbińska, Maciej Kondrusik, Justyna Dunaj, Joanna Zajkowska, Anna Moniuszko-Malinowska
AIM: The aim of the study was to assess the role of an early specific humoral response in human infection with a tick-borne encephalitis virus (TBEV) and the role of IL-5 as its potential mediator and marker. MATERIALS AND METHODS: The retrospective study involved a cohort of 199 patients diagnosed with TBE, in whom anti-TBEV IgM and IgG antibody titers were analyzed on admission and compared with clinical presentation and basic laboratory parameters. The prospective study included 50 TBE patients in whom IL-5 serum and CSF concentration was measured with ELISA on admission in the TBE neurologic phase and in selected patients before discharge, at follow-up or in samples obtained before the neurologic phase onset...
March 15, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29600131/tick-bite-erythema-migrans
#13
Yoshinosuke Shimamura, Takuto Maeda, Yufu Gocho
This manuscript describes the typical presentation of erythema migrans caused by tick bite. The purposes of this article are (i) to encourage physicians to observe patients with tick bite carefully since it may cause fatal encephalitis, and (ii) to facilitate physicians, especially in endemic areas, to consider tick-borne encephalitis virus as one of the causes of encephalitis.
March 2018: Journal of General and Family Medicine
https://www.readbyqxmd.com/read/29560461/development-of-single-step-rt-pcr-for-detection-of-kyasanur-forest-disease-virus-from-clinical-samples
#14
Gouri Chaubal, Prasad Sarkale, Pravin Kore, Pragya Yadav
Background: Kyasanur Forest Disease (KFD), a tick borne flavivirus, which was earlier endemic to Karnataka state, India, has been confirmed and detected from neighboring states of Tamil Nadu, Maharashtra, Goa and Kerala states in India. Increased human and vector surveillance therefore becomes essential for the identification of KFD affected regions and control of further spread of the disease. Currently, available KFD detection assays include realtime RT-PCR and nested RT-PCR assays...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29560357/crimean-congo-hemorrhagic-fever-virus-and-borrelia-burgdorferi-sensu-lato-in-ticks-from-kosovo-and-albania
#15
Kurtesh Sherifi, Agim Rexhepi, Kristaq Berxholi, Blerta Mehmedi, Rreze M Gecaj, Zamira Hoxha, Anja Joachim, Georg G Duscher
Tick-borne diseases pose a serious threat to human health in South-Eastern Europe, including Kosovo. While Crimean-Congo hemorrhagic fever (CCHF) is a well-known emerging infection in this area, there are no accurate data on Lyme borreliosis and tick-borne encephalitis (TBE). Therefore, we sampled and tested 795 ticks. Ixodes ricinus ( n  = 218), Dermacentor marginatus ( n  = 98), and Haemaphysalis spp. ( n  = 24) were collected from the environment by flagging (all from Kosovo), while Hyalomma marginatum ( n  = 199 from Kosovo, all from Kosovo) and Rhipicephalus bursa ( n  = 130, 126 from Albania) could be collected only by removal from animal pasture and domestic ruminants...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29555424/tick-borne-encephalitis-virus-in-arthropod-vectors-in-the-far-east-of-russia
#16
Natalia M Pukhovskaya, Olga V Morozova, Nelya P Vysochina, Nadejda B Belozerova, Svetlana V Bakhmetyeva, Nina I Zdanovskaya, Stephen J Seligman, Leonid I Ivanov
Isolates of tick-borne encephalitis virus (TBEV) from arthropod vectors (ticks and mosquitoes) in the Amur, the Jewish Autonomous and the Sakhalin regions as well as on the Khabarovsk territory of the Far East of Russia were studied. Different proportions of four main tick species of the family Ixodidae: Ixodes persulcatus P. Schulze, 1930; Haemaphysalis concinna Koch, 1844; Haemaphysalis japonica douglasi Nuttall et Warburton, 1915 and Dermacentor silvarum Olenev, 1932 were found in forests and near settlements...
February 8, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29554970/ticks-are-more-suitable-than-red-foxes-for-monitoring-zoonotic-tick-borne-pathogens-in-northeastern-italy
#17
Graziana Da Rold, Silvia Ravagnan, Fabio Soppelsa, Elena Porcellato, Mauro Soppelsa, Federica Obber, Carlo Vittorio Citterio, Sara Carlin, Patrizia Danesi, Fabrizio Montarsi, Gioia Capelli
BACKGROUND: Northeastern Italy is a hotspot for several tick-borne pathogens, transmitted to animals and humans mainly by Ixodes ricinus. Here we compare the results of molecular monitoring of ticks and zoonotic TBPs over a six-year period, with the monitoring of red foxes (Vulpes vulpes) in an endemic area. RESULTS: In the period 2011-2016, 2,578 ticks were collected in 38 sites of 20 municipalities of Belluno Province. Individual adults (264), pooled larvae (n = 330) and nymphs (n = 1984) were screened for tick-borne encephalitis virus, Borrelia burgdorferi (s...
March 20, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29545014/identification-and-analysis-of-host-proteins-that-interact-with-the-3-untranslated-region-of-tick-borne-encephalitis-virus-genomic-rna
#18
Memi Muto, Wataru Kamitani, Mizuki Sakai, Minato Hirano, Shintaro Kobayashi, Hiroaki Kariwa, Kentaro Yoshii
Tick-borne encephalitis virus (TBEV) causes severe neurological disease, but the pathogenetic mechanism is unclear. The conformational structure of the 3'-untranslated region (UTR) of TBEV is associated with its virulence. We tried to identify host proteins interacting with the 3'-UTR of TBEV. Cellular proteins of HEK293T cells were co-precipitated with biotinylated RNAs of the 3'-UTR of low- and high-virulence TBEV strains and subjected to mass spectrometry analysis. Fifteen host proteins were found to bind to the 3'-UTR of TBEV, four of which- cold shock domain containing-E1 (CSDE1), spermatid perinuclear RNA binding protein (STRBP), fragile X mental retardation protein (FMRP), and interleukin enhancer binding factor 3 (ILF3)-bound specifically to that of the low-virulence strain...
March 12, 2018: Virus Research
https://www.readbyqxmd.com/read/29544502/cell-type-and-region-specific-restriction-of-neurotropic-flavivirus-infection-by-viperin
#19
Richard Lindqvist, Chaitanya Kurhade, Jonathan D Gilthorpe, Anna K Överby
BACKGROUND: Flaviviruses are a group of diverse and emerging arboviruses and an immense global health problem. A number of flaviviruses are neurotropic, causing severe encephalitis and even death. Type I interferons (IFNs) are the first line of defense of the innate immune system against flavivirus infection. IFNs elicit the concerted action of numerous interferon-stimulated genes (ISGs) to restrict both virus infection and replication. Viperin (virus-inhibitory protein, endoplasmic reticulum-associated, IFN-inducible) is an ISG with broad-spectrum antiviral activity against multiple flaviviruses in vitro...
March 15, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29540659/fatal-meningoencephalomyelitis-due-to-the-tick-borne-encephalitis-virus-the-first-detailed-neurological-observation-in-a-japanese-patient-from-the-central-part-of-hokkaido-island
#20
Yasutaka Tajima, Hiroaki Yaguchi, Yasunori Mito
To date, the only instance of tick-borne encephalitis (TBE) in Japan was reported from the southern part of Hokkaido Island in 1993; no other cases have been reported since then. We herein report the first case of TBE reported in the central part of Hokkaido Island, and describe the fatal clinical course of a patient who presented with meningoencephalomyelitis, which partly involved the nerve root. Magnetic resonance imaging (MRI) of the patient's cranium and spine revealed characteristic central nervous system involvement...
2018: Internal Medicine
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