keyword
MENU ▼
Read by QxMD icon Read
search

Tick borne-encephalitis virus

keyword
https://www.readbyqxmd.com/read/29914165/viral-determinants-of-virulence-in-tick-borne-flaviviruses
#1
REVIEW
Eliza M Kellman, Danielle K Offerdahl, Wessam Melik, Marshall E Bloom
Tick-borne flaviviruses have a global distribution and cause significant human disease, including encephalitis and hemorrhagic fever, and often result in neurologic sequelae. There are two distinct properties that determine the neuropathogenesis of a virus. The ability to invade the central nervous system (CNS) is referred to as the neuroinvasiveness of the agent, while the ability to infect and damage cells within the CNS is referred to as its neurovirulence. Examination of laboratory variants, cDNA clones, natural isolates with varying pathogenicity, and virally encoded immune evasion strategies have contributed extensively to our understanding of these properties...
June 16, 2018: Viruses
https://www.readbyqxmd.com/read/29912706/virus-rna-load-in-patients-with-tick-borne-encephalitis-slovenia
#2
Ana Saksida, Nina Jakopin, Mateja Jelovšek, Nataša Knap, Luka Fajs, Lara Lusa, Stanka Lotrič-Furlan, Petra Bogovič, Maja Arnež, Franc Strle, Tatjana Avšič-Županc
We determined levels of tick-borne encephalitis (TBE) virus (TBEV) RNA in serum samples obtained from 80 patients during the initial phase of TBE in Slovenia. For most samples, levels were within the range of 3-6 log10 copies RNA/mL. Levels were higher in female patients than in male patients, but we found no association between virus load and several laboratory and clinical parameters, including severity of TBE. However, a weak humoral immune response was associated with a more severe disease course, suggesting that inefficient clearance of virus results in a more serious illness...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29911344/powassan-virus-a-scoping-review-of-the-global-evidence
#3
REVIEW
Tricia Corrin, Judy Greig, Shannon Harding, Ian Young, Mariola Mascarenhas, Lisa A Waddell
BACKGROUND: Powassan virus (POWV), a flavivirus discovered in 1958, causes sporadic but severe cases of encephalitis in humans. Since 2007, the number of human Powassan cases diagnosed each year in the USA has steadily increased. This is in agreement with predictions that Powassan cases may increase in North America as a result of increased exposure to infected ticks. However, the increase may also reflect improved diagnostics and reporting among other factors. METHODS: A scoping review was prioritized to identify and characterize the global literature on POWV...
June 17, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29900012/current-status-of-zika-vaccine-development-zika-vaccines-advance-into-clinical-evaluation
#4
REVIEW
Alan D T Barrett
Zika virus (ZIKV), a mosquito-borne flavivirus, was first identified in the 1940s in Uganda in Africa and emerged in the Americas in Brazil in May 2015. In the 30 months since ZIKV emerged as a major public health problem, spectacular progress has been made with vaccine development cumulating with the publication of three reports of phase 1 clinical trials in the 4th quarter of 2017. Clinical trials involving candidate DNA and purified inactivated virus vaccines showed all were safe and well-tolerated in the small number of volunteers and all induced neutralizing antibodies, although these varied by vaccine candidate and dosing regimen...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29882971/breast-milk-transmission-of-flaviviruses-in-the-context-of-zika-virus-a-systematic-review
#5
REVIEW
Taylor Z Mann, Lisa B Haddad, Tonya R Williams, Susan L Hills, Jennifer S Read, Deborah L Dee, Eric J Dziuban, Janice Pérez-Padilla, Denise J Jamieson, Margaret A Honein, Carrie K Shapiro-Mendoza
BACKGROUND: Since the Zika virus epidemic in the Americas began in 2015, Zika virus transmission has occurred throughout the Americas. However, limited information exists regarding possible risks of transmission of Zika virus and other flaviviruses through breast feeding and human milk. We conducted a systematic review of the evidence regarding flaviviruses detection in and transmission through milk, specifically regarding Zika virus, Japanese encephalitis virus, tick-borne encephalitis virus, Powassan virus, West Nile virus, dengue virus, and yellow fever virus...
June 8, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29868166/viral-metagenomics-reveals-the-presence-of-highly-divergent-quaranjavirus-in-rhipicephalus-ticks-from-mozambique
#6
Harindranath Cholleti, Juliette Hayer, Fernando Chanisso Mulandane, Kerstin Falk, Jose Fafetine, Mikael Berg, Anne-Lie Blomström
Background: Ticks are primary vectors for many well-known disease-causing agents that affect human and animal populations globally such as tick-borne encephalitis, Crimean-Congo hemorrhagic fever and African swine fever. In this study, viral metagenomics was used to identify what viruses are present in Rhipicephalus spp. ticks collected in the Zambezi Valley of Mozambique. Methods: The RNA was amplified with sequence-independent single primer amplification (SISPA) and high-throughput sequencing was performed on the Ion Torrent platform...
2018: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/29859999/3-o-substituted-5-perylen-3-ylethynyl-2-deoxyuridines-as-tick-borne-encephalitis-virus-reproduction-inhibitors
#7
Gleb V Proskurin, Alexey A Orlov, Vladimir A Brylev, Liubov I Kozlovskaya, Alexey A Chistov, Galina G Karganova, Vladimir A Palyulin, Dmitry I Osolodkin, Vladimir A Korshun, Andrey V Aralov
A series of analogues of potent antiviral perylene nucleoside dUY11 with methylthiomethyl (MTM), azidomethyl (AZM) and HO-C1-4 -alkyl-1,2,3-triazol-1,4-diyl groups at 3'-O-position as well as the two products of copper-free alkyne-azide cycloaddition of the AZM derivative were prepared and evaluated against tick-borne encephalitis virus (TBEV). Four compounds (4, 6, 8a, 8b) showed EC50  ≤ 10 nM, thus appearing the most potent TBEV inhibitors to date. Moreover, these nucleosides have higher lipophilicity (clogP) and increased solubility in aq...
May 26, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29848409/serologic-evidence-of-tick-borne-encephalitis-virus-infection-in-a-patient-with-suspected-lyme-disease-in-japan
#8
Kentaro Yoshii, Kozue Sato, Mariko Ishizuka, Shintaro Kobayashi, Hiroaki Kariwa, Hiroki Kawabata
Tick-borne encephalitis (TBE) is widely prevalent on the Eurasian continent, including Japan, but four cases of TBE have been reported in Japan. To inspect unconfirmed TBE cases in Japan, we conducted a retrospective seroepidemiological study of a total of 158 samples from 81 meningoencephalitis patients suspected as Lyme disease. Two serum samples from one patient showed neutralizing antibodies against TBE virus. The patient with severe and progressive encephalitis had a history of tick bite in Hokkaido in 2012...
May 29, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29844247/erratum-for-panayiotou-et-al-viperin-restricts-zika-virus-and-tick-borne-encephalitis-virus-replication-by-targeting-ns3-for-proteasomal-degradation
#9
Christakis Panayiotou, Richard Lindqvist, Chaitanya Kurhade, Kirstin Vonderstein, Jenny Pasto, Karin Edlund, Arunkumar S Upadhyay, Anna K Överby
No abstract text is available yet for this article.
June 15, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29797124/mechanisms-of-antiviral-activity-of-the-polyphenol-complex-from-seagrass-of-the-zosteraceae-family-against-tick-borne-encephalitis-virus
#10
N V Krylova, G N Leonova, O S Maystrovskaya, A M Popov, A A Artyukov
Antiviral activity of the polyphenol complex from seagrass of the Zosteraceae family against highly pathogenic strain of the tick-borne encephalitis virus was studied on passaged culture of porcine embryo kidney cells. The antiviral effect of the test compound manifested in a decrease in the infectious titer of the virus and depended on the concentration and application schemes. Polyphenol complex in a concentration of 100 μg/ml suppressed accumulation of the pathogen in the cell culture: pretreatment of the virus reduced its titer by 4 log, pretreatment of cells by 1...
May 24, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29763485/what-s-eating-you-ixodes-tick-and-related-diseases-part-2-diagnosis-and-treatment-of-regional-tick-borne-diseases
#11
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. Although Lyme disease is the most prevalent zoonosis transmitted by Ixodes ticks, other less common diseases may be encountered, including human granulocytic anaplasmosis, babesiosis, Powassan virus infection, tick-borne encephalitis, Borrelia miyamotoi disease, and tick paralysis. In part 2 of this review, disease presentation, diagnosis, and treatment of these less commonly encountered tick-borne diseases are discussed.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29760190/tick-borne-encephalitis-virus-nonstructural-protein-ns5-induces-rantes-expression-dependent-on-the-rna-dependent-rna-polymerase-activity
#12
Zifeng Zheng, Jieyu Yang, Xuan Jiang, Yalan Liu, Xiaowei Zhang, Mei Li, Mudan Zhang, Ming Fu, Kai Hu, Hanzhong Wang, Min-Hua Luo, Peng Gong, Qinxue Hu
Tick-borne encephalitis virus (TBEV) is one of the flaviviruses that targets the CNS and causes encephalitis in humans. The mechanism of TBEV that causes CNS destruction remains unclear. It has been reported that RANTES-mediated migration of human blood monocytes and T lymphocytes is specifically induced in the brain of mice infected with TBEV, which causes ensuing neuroinflammation and may contribute to brain destruction. However, the viral components responsible for RANTES induction and the underlying mechanisms remain to be fully addressed...
May 14, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29745301/comparative-genome-analysis-of-alkhumra-hemorrhagic-fever-virus-with-kyasanur-forest-disease-and-tick-borne-encephalitis-viruses-by-the-in-silico-approach
#13
Navaneethan Palanisamy, Dario Akaberi, Johan Lennerstrand, Åke Lundkvist
Alkhumra hemorrhagic fever virus (AHFV), a relatively new member of the Flaviviruses, was discovered in Saudi Arabia 23 years ago. AHFV is classified in the tick-borne encephalitis virus serocomplex, along with the Kyasanur forest disease virus (KFDV) and tick-borne encephalitis virus (TBEV). Currently, very little is known about the pathologies of AHFV. In this study, using the available genome information of AHFV, KFDV and TBEV, we have predicted and compared the following aspects of these viruses: evolution, nucleotide and protein compositions, recombination, codon frequency, substitution rate, N- and O-glycosylation sites, signal peptide and cleavage site, transmembrane region, secondary structure of 5' and 3' UTRs and RNA-RNA interactions...
May 10, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29742014/complete-genomic-characterization-of-three-tick-borne-encephalitis-viruses-detected-along-the-china-north-korea-border-2011
#14
Xiaoxia He, Junwei Zhao, Shihong Fu, Lisi Yao, Xiaoyan Gao, Yan Liu, Ying He, Guodong Liang, Huanyu Wang
Tick-borne encephalitis virus (TBEV) causes neurological infections with serious sequelae in Europe and Northeast Asia. In China, the major epidemic areas are along the borders with Russia and North Korea. Although several TBEV isolates have been reported, the biological characteristics of the Chinese strains, especially those along the China-North Korea border, are unclear. In this study, we detected seven TBEV fragment sequences in 602 adult Dermacentor silvarum collected in the Changbai Mountain area of Jilin Province on the China-North Korea border and characterized the genome of three TBEV strains (JLCB11-08, JLCB11-35, and JLCB11-40)...
May 9, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29718024/what-s-eating-you-ixodes-tick-and-related-diseases-part-1-life-cycle-local-reactions-and-lyme-disease
#15
Kelsey D Wilson, Dirk M Elston
The Ixodes tick is an important arthropod vector in the transmission of human disease. This 3-part review highlights the biology of the Ixodes tick and manifestations of related diseases. Part 1 addresses the Ixodes tick biology and life cycle; local reactions; and Lyme disease, the most prevalent of associated diseases. Part 2 will address human granulocytic anaplasmosis, babesiosis, Powassan virus infection, Borrelia miyamotoi disease, tick-borne encephalitis, and tick paralysis. Part 3 will address coinfection with multiple pathogens as well as methods of tick-bite prevention and tick removal...
March 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29713635/detection-of-tick-borne-pathogens-in-lambs-undergoing-prophylactic-treatment-against-ticks-on-two-swedish-farms
#16
Giulio Grandi, Anna Aspán, Jenny Pihl, Katarina Gustafsson, Fredrik Engström, Tomas Jinnerot, Robert Söderlund, Jan Chirico
Tick-borne pathogens (TBPs), especially Anaplasma phagocytophilum , cause disease in grazing livestock. Tick prophylaxis is, therefore, a routine practice in sheep flocks in Sweden, especially in central, southern, and coastal areas of the country where ixodid ticks ( Ixodes ricinus and Haemaphysalis punctata ) are present. In the present study, the status of infection by A. phagocytophilum and other TBPs in lambs treated with tick prophylaxis has been assessed serologically and with polymerase chain reaction (PCR)...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29709065/probing-chemical-space-of-tick-borne-encephalitis-virus-reproduction-inhibitors-with-organoselenium-compounds
#17
Alexey A Orlov, Anastasia A Eletskaya, Konstantin A Frolov, Anastasia D Golinets, Vladimir A Palyulin, Sergey G Krivokolysko, Liubov I Kozlovskaya, Victor V Dotsenko, Dmitry I Osolodkin
Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is the leading cause of arboviral neuroinfections in Europe. Only a few classes of the nucleoside and non-nucleoside inhibitors were investigated against TBEV reproduction. Paving the way to previously unexplored areas of anti-TBEV chemical space, we assessed the inhibition of TBEV reproduction in the plaque reduction assay by various compounds derived from cyanothioacetamide and cyanoselenoacetamide. Compounds from seven classes, including 4-(alkylthio)-2-aryl-3-azaspiro[5...
June 2018: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29701628/seroprevalence-survey-of-arboviruses-in-workers-from-tuscany-italy
#18
Maria Elena Remoli, Cristiano Fiorentini, Antonella Marchi, Simona Di Renzi, Nicoletta Vonesch, Maria Vittoria Peri, Lucia Bastianini, Sonia Rossi, Giulia Bartoccini, Maya Lissa Kuttappasery, Maria Grazia Ciufolini, Paola Tomao
BACKGROUND: Arthropod-borne viruses (Arbovirus) play an important role among emerging and re-emerging infectious diseases and in the spreading of infections in new geographic areas. Although some arboviral infections may be asymptomatic or mild flu-like illnesses, many occur as severe forms of meningitis and meningoencephalitis. OBJECTIVES: To assess whether arboviral infections may be associated with occupational risk, in a population of agricultural and forestry workers potentially at high risk for arthropods bite and sting...
January 30, 2018: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29695688/-human-genetic-predisposition-to-diseases-caused-by-viruses-from-flaviviridae-family
#19
N S Yudin, A V Barkhash, V N Maksimov, E V Ignatieva, A G Romaschenko
The identification of human predisposition genes to severe forms of infectious diseases is important for understanding the mechanisms of pathogenesis, as well as for the detection of the risk groups. This will allow one to carry out targeted vaccination and preventive therapy. The most common approaches to the genetic risk estimation include conducting association studies, in which the groups of patients and control individuals are compared using both preliminarily selected candidate genes and using genome-wide analysis...
March 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29691370/a-new-subtype-of-eastern-tick-borne-encephalitis-virus-discovered-in-qinghai-tibet-plateau-china
#20
Xiaoyi Dai, Guobao Shang, Shan Lu, Jing Yang, Jianguo Xu
Tick-borne encephalitis virus (TBEV) has been classified into three subtypes, namely the European (Eu-TBEV), Far Eastern (FE-TBEV), and Siberian (Sib-TBEV). In this study, we discovered a new subtype of TBEV in wild rodent Marmota himalayana in Qinghai-Tibet Plateau in China, proposed as subtype Himalayan (Him-TBEV). Two complete genomes of TBEV were obtained from respiratory samples of 200 marmots. The phylogenetic analysis using the E protein and polyprotein demonstrated that the two strains of Him-TBEV formed an independent branch, separated from Eu-TBEV, Sib-TBEV, and FE-TBEV...
April 25, 2018: Emerging Microbes & Infections
keyword
keyword
78312
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"