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Tick borne-encephalitis virus

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https://www.readbyqxmd.com/read/28086865/rnai-reveals-proteins-for-metabolism-and-protein-processing-associated-with-langat-virus-infection-in-ixodes-scapularis-black-legged-tick-ise6-cells
#1
Jeffrey M Grabowski, Monika Gulia-Nuss, Richard J Kuhn, Catherine A Hill
BACKGROUND: Tick-borne flaviviruses (TBFs) cause thousands of human cases of encephalitis worldwide each year, with some TBF infections progressing to hemorrhagic fever. TBFs are of medical and veterinary importance and strategies to reduce flavivirus transmission by the tick vector may have significant application. Analyses of the proteome of ISE6 cells derived from the black legged tick, Ixodes scapularis infected with the TBF, Langat virus (LGTV), have provided insights into proteins and cellular processes involved with LGTV infection...
January 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28077444/protein-interactions-during-the-flavivirus-and-hepacivirus-life-cycle
#2
Gisa Gerold, Janina Bruening, Bettina Weigel, Thomas Pietschmann
Protein-protein interactions govern biological functions in cells, in the extracellular milieu and at the border between cells and extracellular space. Viruses are small intracellular parasites and thus rely on protein interactions to produce progeny inside host cells and to spread from cell to cell. Usage of host proteins by viruses can have severe consequences e.g. apoptosis, metabolic disequilibria or altered cell proliferation and mobility. Understanding protein interactions during virus infection can thus educate us on viral infection and pathogenesis mechanisms...
January 11, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28073402/deep-sequencing-analysis-of-tick-borne-encephalitis-virus-from-questing-ticks-at-natural-foci-reveals-similarities-between-quasispecies-pools-of-the-virus
#3
Naveed Asghar, John H-O Pettersson, Patrik Dinnetz, Åshild Andreassen, Magnus Johansson
Every year, tick-borne encephalitis virus (TBEV) causes severe central nervous system infection in 10,000 to 15,000 people in Europe and Asia. TBEV is maintained in the environment by an enzootic cycle that requires a tick vector and a vertebrate host, and the adaptation of TBEV to vertebrate and invertebrate environments is essential for TBEV persistence in nature. This adaptation is facilitated by the error-prone nature of the virus' RNA-dependent RNA polymerase that generates genetically distinct virus variants called quasispecies...
January 10, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28035113/serological-surveillance-of-vector-borne-and-zoonotic-diseases-among-hunters-in-eastern-poland
#4
Małgorzata Tokarska-Rodak, Dorota Plewik, Aleksander J Michalski, Marcin Kołodziej, Alicja Mełgieś, Anna Pańczuk, Henryk Konon, Marcin Niemcewicz
BACKGROUND & OBJECTIVES: Many etiological agents of zoonoses are considered as significant biological hazard to people visiting forested areas frequently, for instance, hunters. They may be exposed to ticks, rodents, and birds as well as excreta/secretions of wild animals or contaminated water and soil. Hence, this population is at risk of contracting infection with pathogens such as Borrelia burgdorferi sensu lato (s.l.), Anaplasma phagocytophilum, Babesia spp., tick-borne encephalitis virus, Bartonella spp...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/27987206/zika-virus-is-not-thermostable-very-effective-virus-inactivation-during-heat-treatment-pasteurization-of-human-serum-albumin
#5
Maria R Farcet, Thomas R Kreil
BACKGROUND: The ongoing Zika virus (ZIKV) outbreak in the Americas has also raised concerns around the potential for ZIKV transmission via blood products. Plasma-derived products are considered safe, because effective viral-inactivation and removal methods are implemented in their manufacturing processes. However, a recent study has indicated that ZIKV is "thermally stable" compared with the closely related Dengue virus, thus raising the question of whether heat treatments, as embedded in the manufacturing of plasma-derived products, are as effective against ZIKV as was previously shown for other Flaviviruses...
December 17, 2016: Transfusion
https://www.readbyqxmd.com/read/27982069/the-role-of-the-poly-a-tract-in-the-replication-and-virulence-of-tick-borne-encephalitis-virus
#6
Naveed Asghar, Yi-Ping Lee, Emma Nilsson, Richard Lindqvist, Wessam Melik, Andrea Kröger, Anna K Överby, Magnus Johansson
The tick-borne encephalitis virus (TBEV) is a flavivirus transmitted to humans, usually via tick bites. The virus causes tick-borne encephalitis (TBE) in humans, and symptoms range from mild flu-like symptoms to severe and long-lasting sequelae, including permanent brain damage. It has been suggested that within the population of viruses transmitted to the mammalian host, quasispecies with neurotropic properties might become dominant in the host resulting in neurological symptoms. We previously demonstrated the existence of TBEV variants with variable poly(A) tracts within a single blood-fed tick...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977670/serological-evidence-of-contrasted-exposure-to-arboviral-infections-between-islands-of-the-union-of-comoros-indian-ocean
#7
Koussay Dellagi, Nicolas Salez, Marianne Maquart, Sophie Larrieu, Amina Yssouf, Rahamatou Silaï, Isabelle Leparc-Goffart, Pablo Tortosa, Xavier de Lamballerie
A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1-4...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27918952/evaluation-of-nf-%C3%AE%C2%BAb-concentration-in-patients-with-tick-borne-encephalitis-neuroborreliosis-anaplasmosis-and-anaplasma-phagocythophilum-with-tick-borne-encephalitis-virus-co-infection
#8
Anna Moniuszko-Malinowska, Piotr Czupryna, Justyna Dunaj, Renata Swierzbinska, Katarzyna Guziejko, Ryszard Rutkowski, Joanna Zajkowska, Sambor Grygorczuk, Maciej Kondrusik, Sławomir Pancewicz
OBJECTIVES: The aim of the study was the evaluation of NF-κB concentration in serum and cerebrospinal fluid (CSF) of patients with diagnosis of tick-borne diseases: tick-borne encephalitis (TBE), neuroborreliosis (NB), anaplasmosis (ANA) and patients co-infected with tick-borne encephalitis virus and Anaplasma phagocythophilum (TBE+ANA). Additionally NF-κB concentration during acute and convalescent period was compared. METHODS: Sixty-seven patients with diagnosis of tick-borne diseases were included in the study...
December 2, 2016: Cytokine
https://www.readbyqxmd.com/read/27884572/tick-borne-encephalitis-virus-neutralization-by-high-dose-intravenous-immunoglobulin
#9
Jana Elsterova, Martin Palus, Jana Sirmarova, Jan Kopecky, Hans Helmut Niller, Daniel Ruzek
Tick-borne encephalitis (TBE) is a potentially lethal neuroinfection in humans, caused by TBE virus (TBEV). Currently, there are no approved therapeutic agents to treat TBE. Previously, it was suggested that application of high dose intravenous immunoglobulin (IVIG) may pose potentially successful treatment for severe cases of TBE. In this study, we determined the titers of TBEV-neutralizing antibodies in two IVIG lots originating from the same manufacturer, and tested their ability to treat a lethal TBEV-infection in a mouse model...
November 18, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27875810/nonstructural-protein-1-of-tick-borne-encephalitis-virus-induces-oxidative-stress-and-activates-antioxidant-defense-by-the-nrf2-are-pathway
#10
Yulia V Kuzmenko, Olga A Smirnova, Alexander V Ivanov, Elizaveta S Starodubova, Vadim L Karpov
BACKGROUND: Infection with tick-borne encephalitis virus (TBEV) causes pathological changes in the central nervous system. However, the possible redox alterations in the infected cells that can contribute to the virus pathogenicity remain unknown. OBJECTIVE: In the current study we explored the ability of TBEV nonstructural protein 1 (NS1) to induce oxidative stress and activate antioxidant defense via the nuclear factor (erythroid-derived-2)-like 2/antioxidant response element (Nrf2/ARE) pathway...
2016: Intervirology
https://www.readbyqxmd.com/read/27846275/prevalence-of-rickettsia-spp-in-ticks-and-serological-and-clinical-outcomes-in-tick-bitten-individuals-in-sweden-and-on-the-%C3%A3-land-islands
#11
Anders Lindblom, Katarina Wallménius, Johanna Sjöwall, Linda Fryland, Peter Wilhelmsson, Per-Eric Lindgren, Pia Forsberg, Kenneth Nilsson
Tick-transmitted diseases are an emerging health problem, and the hard tick Ixodes ricinus is the main vector for Borrelia spp., tick-borne encephalitis virus and most of the spotted fever Rickettsiae in Europe. The aim of the present study was to examine the incidence of rickettsial infection in the southernmost and south central parts of Sweden and the Åland Islands in Finland, the risk of infection in humans and its correlation with a bite of a Rickettsia-infected tick, the self-reported symptoms of rickettsial disease, and the prevalence of co-infection between Rickettsia spp...
2016: PloS One
https://www.readbyqxmd.com/read/27795275/complete-genome-sequence-of-a-low-virulence-tick-borne-encephalitis-virus-strain
#12
G Dobler, M Bestehorn, M Antwerpen, A Överby-Wernstedt
We report here the complete genome sequence (GenBank accession no. KX268728) of tick-borne encephalitis strain HB171/11, isolated from an Ixodes ricinus tick from a natural focus where human neurological disease is rare. The strain shows unique characteristics in neuroinvasiveness and neurovirulence.
October 20, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27776548/fast-type-i-interferon-response-protects-astrocytes-from-flavivirus-infection-and-virus-induced-cytopathic-effects
#13
Richard Lindqvist, Filip Mundt, Jonathan D Gilthorpe, Silke Wölfel, Nelson O Gekara, Andrea Kröger, Anna K Överby
BACKGROUND: Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined...
October 24, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27765140/-progress-in-research-of-tick-borne-encephalitis
#14
Y Yang, Y D Du
Tick-borne encephalitis, also called forest encephalitis, is caused by tick-borne encephalitis virus. Central nervous system lesion is the major clinical symptom of tick-borne encephalitis, as an acute infectious disease, the case fatality rate is as high as 10%-20%. Virology experts consider it as a key and difficult point in recent years. This paper summarizes the progress in research of epidemiological characteristics, pathogenesis, clinical manifestations, outcome, diagnosis and treatment of tick-borne encephalitis to provide evidence for the prevention and treatment of tick-borne encephalitis...
October 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/27760182/revisiting-recombination-signal-in-the-tick-borne-encephalitis-virus-a-simulation-approach
#15
Yann J K Bertrand, Magnus Johansson, Peter Norberg
The hypothesis of wide spread reticulate evolution in Tick-Borne Encephalitis virus (TBEV) has recently gained momentum with several publications describing past recombination events involving various TBEV clades. Despite a large body of work, no consensus has yet emerged on TBEV evolutionary dynamics. Understanding the occurrence and frequency of recombination in TBEV bears significant impact on epidemiology, evolution, and vaccination with live vaccines. In this study, we investigated the possibility of detecting recombination events in TBEV by simulating recombinations at several locations on the virus' phylogenetic tree and for different lengths of recombining fragments...
2016: PloS One
https://www.readbyqxmd.com/read/27726774/emerging-foodborne-and-agriculture-related-viruses
#16
David H Kingsley
Viruses rapidly evolve and can emerge in unpredictable ways. Transmission pathways by which foodborne viruses may enter human populations and evolutionary mechanisms by which viruses can become virulent are discussed in this chapter. A majority of viruses emerge from zoonotic animal reservoirs, often by adapting and infecting intermediate hosts, such as domestic animals and livestock. Viruses that are known foodborne threats include hepatitis E virus, tick-borne encephalitis virus, enteroviruses, adenovirus, and astroviruses, among others...
August 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27717318/recombinant-domains-iii-of-tick-borne-encephalitis-virus-envelope-protein-in-combination-with-dextran-and-cpgs-induce-immune-response-and-partial-protectiveness-against-tbe-virus-infection-in-mice
#17
Anna S Ershova, Olga A Gra, Alexander M Lyaschuk, Tatyana M Grunina, Artem P Tkachuk, Mikhail S Bartov, Darya M Savina, Olga V Sergienko, Zoya M Galushkina, Vladimir P Gudov, Liubov I Kozlovskaya, Ivan S Kholodilov, Larissa V Gmyl, Galina G Karganova, Vladimir G Lunin, Anna S Karyagina, Alexander L Gintsburg
BACKGROUND: E protein of tick-borne encephalitis virus (TBEV) and other flaviviruses is located on the surface of the viral particle. Domain III of this protein seems to be a promising component of subunit vaccines for prophylaxis of TBE and kits for diagnostics of TBEV. METHODS: Three variants of recombinant TBEV E protein domain III of European, Siberian and Far Eastern subtypes fused with dextran-binding domain of Leuconostoc citreum KM20 were expressed in E...
October 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27715427/tick-borne-encephalitis-what-travelers-should-know-when-visiting-an-endemic-country
#18
Aleš Chrdle, Václav Chmelík, Daniel Růžek
Tick-borne encephalitis (TBE) is an acute febrile illness with neurological manifestations that is prevalent in forested areas of moderate climate in Europe and Asia. TBE virus is transmitted by ticks and rarely by unpasteurized milk and dairy products. The disease burden is attributed mainly to resulting long-term disability, especially in individuals over 50 y of age. Currently, there is no causative treatment, but a very effective vaccination is available with a good safety profile. The vaccination requires 3 basic doses to be fully effective and regular boosters afterwards...
October 2, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27702593/lipids-and-flaviviruses-present-and-future-perspectives-for-the-control-of-dengue-zika-and-west-nile-viruses
#19
REVIEW
Miguel A Martín-Acebes, Ángela Vázquez-Calvo, Juan-Carlos Saiz
Flaviviruses are emerging arthropod-borne pathogens that cause life-threatening diseases such as yellow fever, dengue, West Nile encephalitis, tick-borne encephalitis, Kyasanur Forest disease, tick-borne encephalitis, or Zika disease. This viral genus groups >50 viral species of small enveloped plus strand RNA virus that are phylogenetically closely related to hepatitis C virus. Importantly, the flavivirus life cycle is intimately associated to host cell lipids. Along this line, flaviviruses rearrange intracellular membranes from the endoplasmic-reticulum of the infected cells to develop adequate platforms for viral replication and particle biogenesis...
October 1, 2016: Progress in Lipid Research
https://www.readbyqxmd.com/read/27663720/the-role-of-mouse-2-5-oligoadenylate-synthetase-1-paralogs
#20
Enas Elkhateeb, Hassan T Tag-El-Din-Hassan, Nobuya Sasaki, Daisuke Torigoe, Masami Morimatsu, Takashi Agui
The interferon-induced oligoadenylate synthetase (OAS) family is one of the most important immune response proteins to the viral infection. The OAS protein binds dsRNA and is activated to produce 2',5'-oligoadenylates, which lead to the activation of latent form of RNase L, resulting in degradation of cellular and viral RNA and inhibition of viral replication. In mice, the Oas gene family locates on chromosome 5. The mouse Oas gene locus undergoes a recent series of duplication event, leading to the presence of eight paralogs of Oas1 genes (Oas1a through Oas1h) that forms Oas gene cluster with the Oas2, Oas3 and two OasL (OasL1 and OasL2) genes...
September 21, 2016: Infection, Genetics and Evolution
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