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Yellow fever virus

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https://www.readbyqxmd.com/read/29331320/zika-dengue-and-yellow-fever-viruses-induce-differential-anti-viral-immune-responses-in-human-monocytic-and-first-trimester-trophoblast-cells
#1
Huanle Luo, Evandro R Winkelmann, Ildefonso Fernandez-Salas, Li Li, Sandra V Mayer, Rogelio Daniz-Lozano, Rosa Ma Sanchez-Casas, Nikos Vasilakis, Robert Tesh, Alan D Barrett, Scott C Weaver, Tian Wang
Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neonatal birth defects, but the causative mechanism is incompletely understood. ZIKV shares sequence homology and early clinical manifestations with yellow fever virus (YFV) and dengue virus (DENV) and are all transmitted in urban cycles by the same species of mosquitoes. However, YFV and DENV have been rarely reported to cause congenital diseases. Here, we compared infection with a contemporary ZIKV strain (FSS13025) to YFV17D and DENV-4 in human monocytic cells (THP-1) and first-trimester trophoblasts (HTR-8)...
January 10, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29330423/t-cell-immunity-to-zika-virus-targets-immunodominant-epitopes-that-show-cross-reactivity-with-other-flaviviruses
#2
C J Reynolds, O M Suleyman, A M Ortega-Prieto, J K Skelton, P Bonnesoeur, A Blohm, V Carregaro, J S Silva, E A James, B Maillère, M Dorner, R J Boyton, D M Altmann
Zika virus (ZIKV) Infection has several outcomes from asymptomatic exposure to rash, conjunctivitis, Guillain-Barré syndrome or congenital Zika syndrome. Analysis of ZIKV immunity is confounded by the fact that several related Flaviviruses infect humans, including Dengue virus 1-4, West Nile virus and Yellow Fever virus. HLA class II restricted T cell cross-reactivity between ZIKV and other Flaviviruses infection(s) or vaccination may contribute to protection or to enhanced immunopathology. We mapped immunodominant, HLA class II restricted, CD4 epitopes from ZIKV Envelope (Env), and Non-structural (NS) NS1, NS3 and NS5 antigens in HLA class II transgenic mice...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324233/bcg-vaccination-protects-against-experimental-viral-infection-in-humans-through-the-induction-of-cytokines-associated-with-trained-immunity
#3
Rob J W Arts, Simone J C F M Moorlag, Boris Novakovic, Yang Li, Shuang-Yin Wang, Marije Oosting, Vinod Kumar, Ramnik J Xavier, Cisca Wijmenga, Leo A B Joosten, Chantal B E M Reusken, Christine S Benn, Peter Aaby, Marion P Koopmans, Hendrik G Stunnenberg, Reinout van Crevel, Mihai G Netea
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial effects against non-related infections. The basis of these effects has been poorly explored in humans. In a randomized placebo-controlled human challenge study, we found that BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain. Epigenetic reprogramming was accompanied by functional changes indicative of trained immunity...
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29322519/inactivation-of-chikungunya-virus-in-blood-components-treated-with-amotosalen-ultraviolet-a-light-or-amustaline-glutathione
#4
Andrew Laughhunn, Yan-Jang S Huang, Dana L Vanlandingham, Marion C Lanteri, Adonis Stassinopoulos
BACKGROUND: Chikungunya virus, a mosquito-borne arbovirus, often co-circulates with the Zika, dengue, and yellow fever viruses in Aedes mosquito-infested areas where cases of arbovirus transfusion-transmitted infections have been reported. Building on past experience to help maintain the availability of safe components during major outbreaks of chikungunya virus in La Reunion, Italy, and Thailand and of Zika virus in the Pacific, the Caribbean, and the Americas, pathogen inactivation is a mitigation strategy to reduce the risk of transfusion-transmitted infection...
January 10, 2018: Transfusion
https://www.readbyqxmd.com/read/29321318/viperin-restricts-zika-virus-and-tick-borne-encephalitis-virus-replication-by-targeting-ns3-for-proteasomal-degradation
#5
Christakis Panayiotou, Richard Lindqvist, Chaitanya Kurhade, Kirstin Vonderstein, Jenny Pasto, Karin Edlund, Arunkumar S Upadhyay, Anna K Överby
Flaviviruses are arthropod-borne viruses that constitute a major global health problem, with millions of human infections annually. Their pathogenesis ranges from mild illness to severe manifestations such as hemorrhagic fever and fatal encephalitis. Type I interferons (IFNs) are induced in response to viral infection, and stimulate the expression of interferon-stimulated genes (ISGs), including that encoding viperin (virus-inhibitory protein, endoplasmic reticulum-associated, IFN-inducible), which shows antiviral activity against a broad spectrum of viruses including several flaviviruses...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29314584/qsar-analysis-of-plant-derived-compounds-with-larvicidal-activity-against-zika-aedes-aegypti-diptera-culicidae-vector-using-freely-available-descriptors
#6
Laura M Saavedra, Gustavo P Romanelli, Pablo R Duchowicz
BACKGROUND: We develop a QSAR model for predicting the larvicidal activity of 60 plant-derived molecules against Aedes aegypti L. (Diptera: Culicidae), vector of several diseases such as, dengue, yellow fever, chikungunya and Zika virus. The balanced subsets method (BSM) based on k-means cluster analysis (k-MCA) is employed to split the data set. The replacement method (RM) variable subset selection technique coupled with multivariable linear regression (MLR) proves to be successful for exploring 18,326 molecular descriptors and fingerprints calculated with PaDEL, Mold2 and EPI Suite open-source software...
January 4, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29305089/how-do-virus-mosquito-interactions-lead-to-viral-emergence
#7
REVIEW
Claudia Rückert, Gregory D Ebel
Arboviruses such as West Nile, Zika, chikungunya, dengue, and yellow fever viruses have become highly significant global pathogens through unexpected, explosive outbreaks. While the rapid progression and frequency of recent arbovirus outbreaks is associated with long-term changes in human behavior (globalization, urbanization, climate change), there are direct mosquito-virus interactions which drive shifts in host range and alter virus transmission. This review summarizes how virus-mosquito interactions are critical for these viruses to become global pathogens at molecular, physiological, evolutionary, and epidemiological scales...
January 2, 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29288700/erythrosin-b-is-a-potent-and-broad-spectrum-orthosteric-inhibitor-of-the-flavivirus-ns2b-ns3-protease
#8
Zhong Li, Srilatha Sakamuru, Ruili Huang, Matthew Brecher, Cheri A Koetzner, Jing Zhang, Haiying Chen, Cheng-Feng Qin, Qing-Yu Zhang, Jia Zhou, Laura D Kramer, Menghang Xia, Hongmin Li
Many flaviviruses, such as Zika virus (ZIKV), Dengue virus (DENV1-4) and yellow fever virus (YFV), are significant human pathogens. Infection with ZIKV, an emerging mosquito-borne flavivirus, is associated with increased risk of microcephaly in newborns and Guillain-Barré syndrome and other complications in adults. Currently, specific therapy does not exist for any flavivirus infections. In this study, we found that erythrosin B, an FDA-approved food additive, is a potent inhibitor for flaviviruses, including ZIKV and DENV2...
December 27, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29285718/crystal-structure-of-the-c-terminal-fragment-of-ns1-protein-from-yellow-fever-virus
#9
Haiyuan Wang, Min Han, Jianxun Qi, Rolf Hilgenfeld, Tingrong Luo, Yi Shi, George F Gao, Hao Song
No abstract text is available yet for this article.
November 29, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29284522/dengue-and-yellow-fever-virus-vectors-seasonal-abundance-diversity-and-resting-preferences-in-three-kenyan-cities
#10
Sheila B Agha, David P Tchouassi, Armanda D S Bastos, Rosemary Sang
BACKGROUND: The transmission patterns of dengue (DENV) and yellow fever (YFV) viruses, especially in urban settings, are influenced by Aedes (Stegomyia) mosquito abundance and behavior. Despite recurrent dengue outbreaks on the Kenyan coast, these parameters remain poorly defined in this and other areas of contrasting dengue endemicity in Kenya. In assessing the transmission risk of DENV/YFV in three Kenyan cities, we determined adult abundance and resting habits of potential Aedes (Stegomyia) vectors in Kilifi (dengue-outbreak prone), and Nairobi and Kisumu (no dengue outbreaks reported)...
December 29, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29273403/zika-virus-an-emerging-infectious-disease-with-serious-perinatal-and-neurologic-complications
#11
Thomas B Casale, Michael N Teng, Jamie P Morano, Thomas Unnasch, Charles J Lockwood
Zika virus (ZIKV) is a flavivirus that is primarily transmitted by Aedes aegypti, the mosquito vector also important in the transmission of the flaviviruses responsible for dengue fever, yellow fever and chikungunya. Due to occurrence in the same geographic regions, serological cross-reactivity, and similar, albeit often less severe clinical manifestations as dengue and chikungunya infections, ZIKV infection likely went undetected and/or misdiagnosed for many years. ZIKV is somewhat unique among flaviviruses in its ability to also be transmitted via sexual contact, non-sexual body fluids and perinatally...
December 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29261766/characteristics-of-aedes-aegypti-adult-mosquitoes-in-rural-and-urban-areas-of-western-and-coastal-kenya
#12
Bryson Alberto Ndenga, Francis Maluki Mutuku, Harun Njenga Ngugi, Joel Omari Mbakaya, Peter Aswani, Peter Siema Musunzaji, John Vulule, Dunstan Mukoko, Uriel Kitron, Angelle Desiree LaBeaud
Aedes aegypti is the main vector for yellow fever, dengue, chikungunya and Zika viruses. Recent outbreaks of dengue and chikungunya have been reported in Kenya. Presence and abundance of this vector is associated with the risk for the occurrence and transmission of these diseases. This study aimed to characterize the presence and abundance of Ae. aegypti adult mosquitoes from rural and urban sites in western and coastal regions of Kenya. Presence and abundance of Ae. aegypti adult mosquitoes were determined indoors and outdoors in two western (urban Kisumu and rural Chulaimbo) and two coastal (urban Ukunda and rural Msambweni) sites in Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/29241533/a-small-molecule-oligosaccharyltransferase-inhibitor-with-pan-flaviviral-activity
#13
Andreas S Puschnik, Caleb D Marceau, Yaw Shin Ooi, Karim Majzoub, Natalie Rinis, Joseph N Contessa, Jan E Carette
The mosquito-borne flaviviruses include important human pathogens such as dengue, Zika, West Nile, and yellow fever viruses, which pose a serious threat for global health. Recent genetic screens identified endoplasmic reticulum (ER)-membrane multiprotein complexes, including the oligosaccharyltransferase (OST) complex, as critical flavivirus host factors. Here, we show that a chemical modulator of the OST complex termed NGI-1 has promising antiviral activity against flavivirus infections. We demonstrate that NGI-1 blocks viral RNA replication and that antiviral activity does not depend on inhibition of the N-glycosylation function of the OST...
December 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/29236685/origin-and-differentiation-of-human-memory-cd8-t-cells-after-vaccination
#14
Rama S Akondy, Mark Fitch, Srilatha Edupuganti, Shu Yang, Haydn T Kissick, Kelvin W Li, Ben A Youngblood, Hossam A Abdelsamed, Donald J McGuire, Kristen W Cohen, Gabriela Alexe, Shashi Nagar, Megan M McCausland, Satish Gupta, Pramila Tata, W Nicholas Haining, M Juliana McElrath, David Zhang, Bin Hu, William J Greenleaf, Jorg J Goronzy, Mark J Mulligan, Marc Hellerstein, Rafi Ahmed
The differentiation of human memory CD8 T cells is not well understood. Here we address this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity in humans. We used in vivo deuterium labelling to mark CD8 T cells that proliferated in response to the virus and then assessed cellular turnover and longevity by quantifying deuterium dilution kinetics in YFV-specific CD8 T cells using mass spectrometry. This longitudinal analysis showed that the memory pool originates from CD8 T cells that divided extensively during the first two weeks after infection and is maintained by quiescent cells that divide less than once every year (doubling time of over 450 days)...
December 13, 2017: Nature
https://www.readbyqxmd.com/read/29231157/plant-produced-subunit-vaccine-candidates-against-yellow-fever-induce-virus-neutralizing-antibodies-and-confer-protection-against-viral-challenge-in-animal-models
#15
Stephen Tottey, Yoko Shoji, R Mark Jones, Jessica A Chichester, Brian J Green, Konstantin Musiychuk, Huaxin Si, Slobodanka Manceva, Amy Rhee, Moneim Shamloul, Joey Norikane, Rosane C Guimarães, Elena Caride, Andrea N M R Silva, Marisol Simões, Patricia C C Neves, Renato Marchevsky, Marcos S Freire, Stephen J Streatfield, Vidadi Yusibov
Yellow fever (YF) is a viral disease transmitted by mosquitoes and endemic mostly in South America and Africa with 20-50% fatality. All current licensed YF vaccines, including YF-Vax® (Sanofi-Pasteur, France) and 17DD-YFV (Bio-Manguinhos, Brazil), are based on live attenuated virus produced in hens' eggs and have been widely used. The YF vaccines are considered safe and highly effective. However, a recent increase in demand for YF vaccines and reports of rare cases of YF vaccine-associated fatal adverse events have provoked interest in developing a safer YF vaccine that can be easily scaled up to meet this increased global demand...
December 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29227202/challenges-of-vaccine-development-for-zika-virus
#16
Marcia A Blackman, In-Jeong Kim, Jr-Shiuan Lin, Stephen J Thomas
The emergence of outbreaks of Zika virus (ZIKV) in Brazil in 2015 was associated with devastating effects on fetal development and prompted a world health emergency and multiple efforts to generate an effective vaccine against infection. There are now more than 40 vaccine candidates in preclinical development and six in clinical trials. Despite similarities with other flaviviruses to which successful vaccines have been developed, such as yellow fever virus and Japanese Encephalitis virus, there are unique challenges to the development and clinical trials of a vaccine for ZIKV...
December 11, 2017: Viral Immunology
https://www.readbyqxmd.com/read/29225429/in-silico-validation-of-d7-salivary-protein-derived-b-and-t-cell-epitopes-of-aedes-aegypti-as-potential-vaccine-to-prevent-transmission-of-flaviviruses-and-togaviruses-to-humans
#17
Sathish Sankar, Mageshbabu Ramamurthy, Balaji Nandagopal, Gopalan Sridharan
Mosquito (Aedes aegyptii) salivary proteins play a crucial role in facilitating viral transmission from vector-to-host due to their role in facilitating the "blood meal" of the vector. Three main proteins, D7, aegyptin and Sialokinin play a role in this process. Using in-silico programs, we identified B- and T-cell epitopes in the mosquito salivary proteins D7 long and short form. T-cell epitopes with high affinity to the most prevalent HLA MHC class-I supertypes among different population groups was chosen...
2017: Bioinformation
https://www.readbyqxmd.com/read/29217264/the-immune-strategies-of-mosquito-aedes-aegypti-against-microbial-infection
#18
Yan-Hong Wang, Meng-Meng Chang, Xue-Li Wang, Ai-Hua Zheng, Zhen Zou
Yellow fever mosquito Aedes aegypti transmits many devastating arthropod-borne viruses (arboviruses), such as dengue virus, yellow fever virus, Chikungunya virus, and Zika virus, which cause great concern to human health. Mosquito control is an effective method to block the spread of infectious diseases. Ae. aegypti uses its innate immune system to fight against arboviruses, parasites, and fungi. In this review, we briefly summarize the recent findings in the immune response of Ae. aegypti against arboviral and entomopathogenic infections...
December 4, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29211109/metagenomic-analysis-reveals-hepatitis-a-virus-in-suspected-yellow-fever-cases-in-brazil
#19
Liliane C Conteville, Ana Maria B de Filippis, Rita Maria R Nogueira, Marcos César L de Mendonça, Ana Carolina P Vicente
Using a metagenomic approach, we identified hepatitis A virus among cases of acute febrile illnesses that occurred in 2008-2012 in Brazil suspected as yellow fever. These findings reinforce the challenge facing routine clinical diagnosis in complex epidemiological scenarios.
January 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29187150/identification-of-pathogens-for-differential-diagnosis-of-fever-with-jaundice-in-the-central-african-republic-a-retrospective-assessment-2008-2010
#20
Christelle Luce Bobossi Gadia, Alexandre Manirakiza, Gaspard Tekpa, Xavier Konamna, Ulrich Vickos, Emmanuel Nakoune
BACKGROUND: Febrile jaundice results clinically in generalized yellow coloration of the teguments and mucous membranes due to excess plasma bilirubin, accompanied by fever. Two types are found: conjugated and unconjugated bilirubin jaundice. Jaundice is a sign in several diseases due to viruses (viral hepatitis and arbovirus), parasites (malaria) and bacteria (leptospirosis). In the Central African Republic (CAR), only yellow fever is included on the list of diseases for surveillance...
November 29, 2017: BMC Infectious Diseases
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