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https://www.readbyqxmd.com/read/29341603/pokmt1-from-the-polyketomycin-biosynthetic-machinery-of-streptomyces-diastatochromogenes-t%C3%A3-6028-belongs-to-the-emerging-family-of-c-methyltransferases-that-act-on-coa-activated-aromatic-substrates
#1
Xun Guo, Ivana Crnovcic, Chin-Yuan Chang, Jun Luo, Jeremy R Lohman, Monica Papinski, Andreas Bechthold, Geoffrey P Horsman, Ben Shen
Recent biochemical characterizations of the MdpB2 CoA ligase and MdpB1 C-methyltransferase (C-MT) from the maduropeptin (MDP, 2) biosynthetic machinery revealed unusual pathway logic involving C-methylation occurring on a CoA-activated aromatic substrate. Here we confirmed this pathway logic for the biosynthesis of polyketomycin (POK, 3). Biochemical characterization unambiguously established that PokM3 and PokMT1 catalyze the sequential conversion of 6-methylsalicylic acid (6-MSA, 4) to form 3,6-dimethylsalicylyl-CoA (3,6-DMSA-CoA, 6), which serves as the direct precursor for the 3,6-dimethylsalicylic acid (3,6-DMSA) moiety in the biosynthesis of 3...
January 17, 2018: Biochemistry
https://www.readbyqxmd.com/read/29340828/hiatal-hernia-recurrence-following-magnetic-sphincter-augmentation-and-posterior-cruroplasty-intermediate-term-outcomes
#2
Kais A Rona, James M Tatum, Joerg Zehetner, Katrin Schwameis, Carol Chow, Kamran Samakar, Adrian Dobrowolsky, Caitlin C Houghton, Nikolai Bildzukewicz, John C Lipham
BACKGROUND: We have previously reported short-term outcomes after hiatal hernia repair (HHR) at the time of magnetic sphincter augmentation (MSA) for gastroesophageal reflux disease (GERD). Here we report intermediate-term outcomes and hernia recurrence rate after concomitant MSA and HHR. METHODS: This is a retrospective cohort study of patients who underwent repair of a hiatal hernia 3 cm or larger at the time of MSA implantation between May 2009 and December 2015...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29322639/prokaryotes-in-the-wais-divide-ice-core-reflect-source-and-transport-changes-between-last-glacial-maximum-and-the-early-holocene
#3
Pamela A Santibáñez, Olivia J Maselli, Mark C Greenwood, Mackenzie M Grieman, Eric S Saltzman, Joseph R McConnell, John C Priscu
We present the first long-term, highly resolved prokaryotic cell concentration record obtained from a polar ice core. This record, obtained from the West Antarctic Ice Sheet (WAIS) Divide (WD) ice core, spanned from the Last Glacial Maximum (LGM) to the early Holocene (EH) and showed distinct fluctuations in prokaryotic cell concentration coincident with major climatic states. The time series also revealed a ~1,500-year periodicity with greater amplitude during the Last Deglaciation (LDG). Higher prokaryotic cell concentration and lower variability occurred during the LGM and EH than during the LDG...
January 11, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29316410/environmental-warming-and-feminization-of-one-of-the-largest-sea-turtle-populations-in-the-world
#4
Michael P Jensen, Camryn D Allen, Tomoharu Eguchi, Ian P Bell, Erin L LaCasella, William A Hilton, Christine A M Hof, Peter H Dutton
Climate change affects species and ecosystems around the globe [1]. The impacts of rising temperature are particularly pertinent in species with temperature-dependent sex determination (TSD), where the sex of an individual is determined by incubation temperature during embryonic development [2]. In sea turtles, the proportion of female hatchlings increases with the incubation temperature. With average global temperature predicted to increase 2.6°C by 2100 [3], many sea turtle populations are in danger of high egg mortality and female-only offspring production...
January 8, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29313153/first-symptoms-in-multiple-system-atrophy
#5
Jake H McKay, William P Cheshire
PURPOSE: The initial symptoms of multiple system atrophy (MSA) and, in particular, early autonomic symptoms, have received less attention than motor symptoms. Whereas pathognomonic motor signs are essential to diagnostic specificity, early symptoms important to recognition of a neurodegenerative disorder may be less apparent or diagnostically ambiguous. This observational study sought to identify the very earliest symptoms in the natural history of MSA. METHODS: Detailed clinical histories focusing on early symptoms were obtained from 30 subjects recently diagnosed with MSA...
January 8, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29310004/influence-of-military-sexual-assault-and-other-military-stressors-on-substance-use-disorder-and-pts-symptomology-in-female-military-veterans
#6
Matthew M Yalch, Claire L Hebenstreit, Shira Maguen
Servicewomen exposed to traumatic stressors over the course of their military service are at increased risk of developing symptoms of substance use disorder (SUD) and posttraumatic stress (PTS). They are also at risk for exposure to military sexual assault (MSA), which is also associated with SUD and PTS symptomology. Research is unclear about the incremental contributions of different forms of traumatic stressors on co-occurring SUD and PTS symptomology. In this study we examined the independent and combined effects of MSA and other military stressors on SUD and PTS symptomology in a sample of female veterans (N=407)...
December 27, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29305061/a-refined-concept-%C3%AE-synuclein-dysregulation-disease
#7
REVIEW
Hideki Mochizuki, Chi-Jing Choong, Eliezer Masliah
α-synuclein (αSyn) still remains a mysterious protein even two decades after SNCA encoding it was identified as the first causative gene of familial Parkinson's disease (PD). Accumulation of αSyn causes α-synucleinopathies including PD, dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Recent advances in therapeutic approaches offer new antibody-, vaccine-, antisense-oligonucleotide- and small molecule-based options to reduce αSyn protein levels and aggregates in patient's brain. Gathering research information of other neurological disease particularly Alzheimer's disease, recent disappointment of an experimental amyloid plaques busting antibody in clinical trials underscores the difficulty of treating people who show even mild dementia as damage in their brain may already be too extensive...
January 2, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29298733/progressive-striatonigral-degeneration%C3%A2-in-a-transgenic-mouse-model-of-multiple-system-atrophy-translational-implications-for-interventional-therapies
#8
Violetta Refolo, Francesco Bez, Alexia Polissidis, Daniela Kuzdas-Wood, Edith Sturm, Martina Kamaratou, Werner Poewe, Leonidas Stefanis, M Angela Cenci, Marina Romero-Ramos, Gregor K Wenning, Nadia Stefanova
Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder characterized by widespread oligodendroglial cytoplasmic inclusions of filamentous α-synuclein, and neuronal loss in autonomic centres, basal ganglia and cerebellar circuits. It has been suggested that primary oligodendroglial α-synucleinopathy may represent a trigger in the pathogenesis of MSA, but the mechanisms underlying selective vulnerability and disease progression are unclear. The post-mortem analysis of MSA brains provides a static final picture of the disease neuropathology, but gives no clear indication on the sequence of pathogenic events in MSA...
January 3, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29290804/an-albumin-binding-polypeptide-both-targets-cytotoxic-t-lymphocyte-vaccines-to-lymph-nodes-and-boosts-vaccine-presentation-by-dendritic-cells
#9
Peng Wang, Peng Zhao, Shuyun Dong, Tiefeng Xu, Xiao He, Mingnan Chen
Rationale: Albumin-binding carriers have been shown to target cytotoxic T lymphocyte (CTL) vaccines to lymph nodes (LNs) and improve the efficacy of the vaccines. However, it was not clear whether the improved efficacy is solely due to the LN targeting, which prompted this study. Methods: First, we generated a fusion protein consisting of an albumin-binding domain (ABD) and an immune-tolerant elastin-like polypeptide (iTEP). Then, we examined the binding between this fusion protein, termed ABD-iTEP, and mouse serum albumin (MSA)...
2018: Theranostics
https://www.readbyqxmd.com/read/29287518/anti-mda5-positive-dermatomyositis-complicated-with-rapidly-progressive-interstitial-lung-disease-a-case-report
#10
Eva De Backer, Félix Gremonprez, Guy Brusselle, Pieter Depuydt, Jo Van Dorpe, Carole Van Haverbeke, Pieter C Goeminne, Eric Derom
CASE PRESENTATION:  We present a case of a 55-year-old Caucasian male with manifestations of dermatomyositis complicated with rapidly progressive interstitial lung disease (RP-ILD). Diagnosis of anti-MDA5 positive dermatomyositis was made. DISCUSSION:  Myositis specific antibodies (MSA) can be used for diagnosis and predicting prognosis in patients with polymyositis and dermatomyositis. Anti-MDA5 positive dermatomyositis should be considered in patients presenting with dermatomyositis and a disease course resembling antisynthetase syndrome in the absence of antisynthetase autoantibodies, especially if a remarkably high ferritin is noted...
December 29, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29287113/diffusion-weighted-mri-distinguishes-parkinson-disease-from-the-parkinsonian-variant-of-multiple-system-atrophy-a-systematic-review-and-meta-analysis
#11
Sweta Bajaj, Florian Krismer, Jose-Alberto Palma, Gregor K Wenning, Horacio Kaufmann, Werner Poewe, Klaus Seppi
BACKGROUND: Putaminal diffusivity in brain magnetic resonance diffusion-weighted imaging (DWI) is increased in patients with the parkinsonian variant of multiple system atrophy (MSA-P) compared to Parkinson disease (PD) patients. PURPOSE: We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of DWI to distinguish MSA-P from PD. METHODS: Studies on DWI were identified through a systematic PubMed and Clarivate Analytics® Web of Science® Core Collection search...
2017: PloS One
https://www.readbyqxmd.com/read/29279394/familial-parkinson-s-point-mutation-abolishes-multiple-system-atrophy-prion-replication
#12
Amanda L Woerman, Sabeen A Kazmi, Smita Patel, Atsushi Aoyagi, Abby Oehler, Kartika Widjaja, Daniel A Mordes, Steven H Olson, Stanley B Prusiner
In the neurodegenerative disease multiple system atrophy (MSA), α-synuclein misfolds into a self-templating conformation to become a prion. To compare the biological activity of α-synuclein prions in MSA and Parkinson's disease (PD), we developed nine α-synuclein-YFP cell lines expressing point mutations responsible for inherited PD. MSA prions robustly infected wild-type, A30P, and A53T α-synuclein-YFP cells, but they were unable to replicate in cells expressing the E46K mutation. Coexpression of the A53T and E46K mutations was unable to rescue MSA prion infection in vitro, establishing that MSA α-synuclein prions are conformationally distinct from the misfolded α-synuclein in PD patients...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29279191/mr-findings-in-the-substantia-nigra-on-phase-difference-enhanced-imaging-in-neurodegenerative-parkinsonism
#13
Atsuhiko Sugiyama, Noriko Sato, Yukio Kimura, Miho Ota, Tomoko Maekawa, Daichi Sone, Mikako Enokizono, Miho Murata, Hiroshi Matsuda, Satoshi Kuwabara
INTRODUCTION: In Parkinson's disease (PD) patients, magnetic resonance (MR) imaging studies using phase difference enhanced imaging (PADRE) and susceptibility-weighted imaging (SWI) showed the obscuration of the boundary between the crural fibers and substantia nigra, and the absence of dorsolateral nigral hyperintensity, respectively. PADRE images have not been evaluated in other types of neurodegenerative parkinsonism, and PADRE and SWI images have not been compared. Here we evaluated PADRE and SWI images in patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), or PD and controls, and we compared the diagnostic values...
December 21, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29278508/are-keggin-s-poms-charged-nano-colloids-or-multicharged-anions
#14
Alla Malinenko, Alban Jonchere, Luc Girard, Sandra Parrès-Maynadié, Olivier Diat, Pierre Bauduin
Owing to their multiple charges and their nanometric size polyoxometalates (POMs) are at the frontier between ions and charged colloids. We investigated here the effect of POM-POM electrostatics repulsions on their self-diffusion in water by varying POM and supporting salt concentrations. The self-diffusion coefficients of two Keggin's POMs: silicotungstate (SiW4-) and phosphotungstate (PW3-) were determined by dynamic light scattering (DLS) and DOSY 1H/31P NMR whereas POM-POM electrostatic repulsions were investigated by the determination of the static structure factors using small angle X-ray scattering (SAXS)...
December 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29251119/association-of-tnf-%C3%AE-rs1799964-and-il-1%C3%AE-rs16944-polymorphisms-with-multiple-system-atrophy-in-chinese-han-population
#15
Xin Zhou, Chunrong Wang, Zhao Chen, Yun Peng, Huirong Peng, Xuan Hou, Wei Ye, Rong Qiu, Kun Xia, Beisha Tang, Hong Jiang
BACKGROUND: Recent evidence suggested that several single nucleotide polymorphisms (SNPs) of inflammation-related genes (TNF-α rs1799964, IL-1α rs1800587, IL-1β rs16944, IL-8 rs4073, ICAM-1 rs5498) were associated with multiple system atrophy (MSA). Herein, we conducted this case-control study to evaluate the possible correlation between the five SNPs related to inflammatory and MSA in Chinese Han population. METHODS AND PATIENTS: We recruited 154 sporadic patients with MSA and 223 health controls in this study...
December 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29249575/combined-cardiovascular-and-sweating-autonomic-testing-to-differentiate-multiple-system-atrophy-from-parkinson-s-disease
#16
Anne Pavy-LeTraon, Christine Brefel-Courbon, Julia Dupouy, Fabienne Ory-Magne, Olivier Rascol, Jean-Michel Senard
OBJECTIVES: It can be difficult to differentiate multiple system atrophy (MSA) with predominant parkinsonism (MSA-P), a very disabling but rare disease, from Parkinson's disease (PD). Autonomic dysfunction, particularly cardiovascular autonomic neuropathy (CAN), is classically more pronounced in MSA. We investigated whether testing for CAN combined with sweat function assessment was helpful to differentiate patients with MSA from those with PD. METHODS: In this retrospective study, 62 patients with MSA-P and 96 with PD, comparable in age, BMI and sex ratio with disease duration of 4...
December 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29249373/idiopathic-cerebellar-ataxia-idca-diagnostic-criteria-and-clinical-analyses-of-63-japanese-patients
#17
Kunihiro Yoshida, Satoshi Kuwabara, Katsuya Nakamura, Ryuta Abe, Akira Matsushima, Minako Beppu, Yoshitaka Yamanaka, Yuji Takahashi, Hidenao Sasaki, Hidehiro Mizusawa
Cortical cerebellar atrophy (CCA) and multiple system atrophy with predominant cerebellar ataxia (MSA-C) are the two major forms of adult-onset sporadic ataxia. Contrary to MSA-C, there are neither diagnostic criteria nor neuroimaging features pathognomonic for CCA. Therefore, it is assumed that the category of CCA in the Japanese national registry include heterogeneous cerebellar ataxic disorders. To refine this category in more detail, we here used a clinical-based term, "idiopathic cerebellar ataxia (IDCA)", and proposed its diagnostic criteria...
January 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29246926/combined-active-humoral-and-cellular-immunization-approaches-for-the-treatment-of-synucleinopathies
#18
Edward Rockenstein, Gary Ostroff, Fusun Dikengil, Florentina Rus, Michael Mante, Jazmin Florio, Anthony Adame, Ivy Trinh, Changyoun Kim, Cassia Overk, Eliezer Masliah, Robert A Rissman
Dementia with Lewy bodies (DLB), Parkinson's disease (PD) and Multiple System Atrophy (MSA) are age-related neurodegenerative disorders characterized by progressive accumulation of α-synuclein (α-syn) and jointly termed synucleinopathies. Currently, no disease-modifying treatments are available for these disorders. Previous preclinical studies showed that active and passive immunizations targeting α-syn partially ameliorates behavioral deficits and α-syn accumulation; however, it is unknown if combining humoral and cellular immunization might act synergistically to reduce inflammation and improve microglial-mediated α-syn clearance...
December 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29246765/fkbp12-immunopositive-inclusions-in-patients-with-%C3%AE-synucleinopathies
#19
Yasuyuki Honjo, Takashi Ayaki, Tomohisa Horibe, Hidefumi Ito, Ryosuke Takahashi, Koji Kawakami
α-Synuclein (α-SYN), a presynaptic protein with the tendency to aggregate, is linked to α-synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). α-SYN is the main component of round intracytoplasmic inclusions called Lewy bodies (LBs), which are the hallmark of PD and DLB. In addition, accumulation of amyloid-β and neurofibrillary tangles as in the pathology of Alzheimer's disease has been found in the DLB brain. Glial cytoplasmic inclusions are an MSA-specific type of inclusion found in oligodendrocytes and mainly comprise α-SYN...
December 12, 2017: Brain Research
https://www.readbyqxmd.com/read/29237794/recommendations-of-the-global-multiple-system-atrophy-research-roadmap-meeting
#20
REVIEW
Ryan R Walsh, Florian Krismer, Wendy R Galpern, Gregor K Wenning, Phillip A Low, Glenda Halliday, Walter J Koroshetz, Janice Holton, Niall P Quinn, Olivier Rascol, Leslie M Shaw, David Eidelberg, Pam Bower, Jeffrey L Cummings, Victor Abler, Judy Biedenharn, Gal Bitan, David J Brooks, Patrik Brundin, Hubert Fernandez, Philip Fortier, Roy Freeman, Thomas Gasser, Art Hewitt, Günter U Höglinger, Matt J Huentelman, Poul H Jensen, Andreas Jeromin, Un Jung Kang, Horacio Kaufmann, Lawrence Kellerman, Vikram Khurana, Thomas Klockgether, Woojin Scott Kim, Carol Langer, Peter LeWitt, Eliezer Masliah, Wassilios Meissner, Ronald Melki, Susanne Ostrowitzki, Steven Piantadosi, Werner Poewe, David Robertson, Cyndi Roemer, Dale Schenk, Michael Schlossmacher, Jeremy D Schmahmann, Klaus Seppi, Lily Shih, Andrew Siderowf, Glenn T Stebbins, Nadia Stefanova, Shoji Tsuji, Sharon Sutton, Jing Zhang
Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy...
January 9, 2018: Neurology
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