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https://www.readbyqxmd.com/read/28105503/using-swallow-tail-sign-and-putaminal-hypointensity-as-biomarkers-to-distinguish-multiple-system-atrophy-from-idiopathic-parkinson-s-disease-a-susceptibility-weighted-imaging-study
#1
Na Wang, HuaGuang Yang, ChengBo Li, GuoGuang Fan, XiaoGuang Luo
OBJECTIVE: To investigate the value of 'swallow-tail' sign and putaminal hypointensity on 3 T susceptibility-weighted imaging (SWI) for distinguishing multiple system atrophy (MSA) from idiopathic Parkinson's disease (IPD). METHODS: Three groups - 39 MSA patients, 18 IPD patients,and 31 healthy controls (HCs) - were administered a 3 T SWI sequence to evaluate 'swallow-tail' sign and putaminal hypointensity using visual scales from 0 to 2 and 0 to 3 scores, respectively...
January 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28093407/protein-multiple-sequence-alignment-benchmarking-through-secondary-structure-prediction
#2
Quan Le, Fabian Sievers, Desmond G Higgins
MOTIVATION: Multiple sequence alignment (MSA) is commonly used to analyse sets of homologous protein or DNA sequences. This has lead to the development of many methods and packages forMSAover the past 30 years. Being able to compare different methods has been problematic and has relied on gold standard benchmark datasets of 'true' alignments or on MSA simulations. A number of protein benchmark datasets have been produced which rely on a combination of manual alignment and/or automated superposition of protein structures...
January 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28089882/a-highly-efficient-modified-human-serum-albumin-signal-peptide-to-secrete-proteins-in-cells-derived-from-different-mammalian-species
#3
Carolina Attallah, Marina Etcheverrigaray, Ricardo Kratje, Marcos Oggero
Signal peptides (SPs) are key elements in the production of recombinant proteins; however, little information is available concerning different SP in mammalian cells other than CHO. In order to study the efficiency of different SPs to direct the traffic along the secretory pathway of the green fluorescence protein (GFP) and a scFv-Fc fusion protein; CHO-K1, HEK293 and NS0 cell lines were transfected in a transient and stable way. SP of human azurocidin (AZ), modified human albumin (mSA), modified Cricetulus griseus Ig kappa chain V III region MOPC 63 like (mIgκ C) and modified human Ig kappa chain V III region VG (mIgκ H) were evaluated...
January 10, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28089508/a-reply-to-douze-and-delagnes-s-the-pattern-of-emergence-of-a-middle-stone-age-tradition-at-gademotta-and-kulluletti-ethiopia-through-convergent-tool-and-point-technologies-j-hum-evol-91-2016-93-121
#4
Yonatan Sahle, David R Braun
Douze and Delagnes (2016) revisit Middle Stone Age (MSA) lithic assemblages from the Gademotta Formation (Fm.), Ethiopia. Their analysis of selected assemblages from three of the 1972 excavations expands the original typo-technological interpretations by Wendorf and Schild (1974). We particularly welcome their evaluation of our recent inferences about the function of pointed artifacts and technological patterns in the Gademotta Fm. (Sahle et al., 2013, 2014). However, we find several arguments and conclusions in Douze and Delagnes (2016) to be rather unconvincing and irreconcilable with results from analyses of whole assemblages (Wendorf and Schild, 1974; Sahle et al...
January 12, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28089067/effect-of-mobile-phase-additives-on-solute-retention-at-low-aqueous-ph-in-hydrophilic-interaction-liquid-chromatography
#5
David V McCalley
Trifluoracetic acid (TFA) added to the aqueous acetonitrile mobile phase induces some unexpected changes in the ionic component of retention in hydrophilic interaction separations when using Type B silica and amide-bonded silica columns. TFA use results in anion exchange properties which contrast with the cation exchange typically found with ammonium salt buffers. The significant cation exchange properties of silica hydride columns are also moderated by TFA. Similar behaviour was shown in a metal- free amide column operated on a system washed with a metal complexing agent, suggesting that adsorbed metal cations were not responsible for this anion exchange behaviour...
December 15, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28077166/threonine-175-a-novel-pathological-phosphorylation-site-on-tau-protein-linked-to-multiple-tauopathies
#6
Alexander J Moszczynski, Wencheng Yang, Robert Hammond, Lee Cyn Ang, Michael J Strong
Microtubule associated protein tau (tau) deposition is associated with a spectrum of neurodegenerative diseases collectively termed tauopathies. We have previously shown that amyotrophic lateral sclerosis (ALS) with cognitive impairment (ALSci) is associated with tau phosphorylation at Thr(175) and that this leads to activation of GSK3β which then induces phosphorylation at tau Thr(231). This latter step leads to dissociation of tau from microtubules and pathological tau fibril formation. To determine the extent to which this pathway is unique to ALS, we have investigated the expression of pThr(175) tau and pThr(231) tau across a range of frontotemporal degenerations...
January 11, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28074921/heat-related-hospitalizations-in-older-adults-an-amplified-effect-of-the-first-seasonal-heatwave
#7
Alexander Liss, Ruiruo Wu, Kenneth Kwan Ho Chui, Elena N Naumova
Older adults are highly vulnerable to the detriment of extreme weather. The rapid non-linear increase in heat-related morbidity is difficult to quantify, hindering the attribution of direct effects of exposure on severe health outcomes. We examine the effects of ambient temperatures on heat-related hospitalizations (HH) among the elderly in presence of strong seasonality and by assessing the effects caused by the first and subsequent seasonal heatwaves. We empirically derived the thresholds for a heatwave episode in Boston MSA based on 16 years of daily observations...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072485/water-soluble-polymer-nanoparticles-constructed-by-three-component-self-assembly-an-efficient-theranostic-agent-for-phosphorescent-imaging-and-photodynamic-therapy
#8
Qi Yang, Min Shi, Heng Zhao, Jiaomin Lin, Lu An, Lili Cui, Hong Yang, Zhiguo Zhou, Qiwei Tian, Shiping Yang
Water soluble polymer nanoparticles (NP-1 and NP-2) were prepared by three-component self-assembly of iridium complex, poly(4-vinyl pyridine-b-ethylene oxide) (P4VP-b-PEO), and methane sulfonic acid (MSA). Due to the unique metal-ligand charge transfer transition property and heavy atom effect of iridium, NP-1 and NP-2 showed bright phosphorescence and generated singlet oxygen (1O2) effectively under visible light irradiation (λ > 400 nm) with a power density of 300 mW/cm2. NP-2, an example of polymer nanoparticles, showed minimal cytotoxic activity in the dark...
January 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28070043/-effects-of-methylseleninic-acid-on-cisplatin-resistant-ovarian-cancer-cells-skov3-ddp-and-the-mechanisms
#9
Ying Tan, Qing Feng, Xin Sun, Min Xue, Ning Jiang, Xinliang Deng
To investigate the reversal effect of methylseleninic acid on cisplatin (DDP)-resistant ovarian cancer cells and the underlying mechanisms.
 Methods: SKOV3/DDP cells were incubated with cisplatin at different concentrations for 48 h, then the proliferation rate of SKOV3/DDP cells was detected by MTT assays, and the expression of β-catenin in SKOV3/DDP cells was examined by Western blot. The inhibitory effect of methyl-seleninic acid (MSA) combined with DDP at different concentrations on SKOV3/DDP cells was assayed by MTT method...
December 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28069167/effect-of-mobile-phase-additives-on-solute-retention-at-low-aqueous-ph-in-hydrophilic-interaction-liquid-chromatography
#10
David V McCalley
Trifluoracetic acid (TFA) added to the aqueous acetonitrile mobile phase induces some unexpected changes in the ionic component of retention in hydrophilic interaction separations when using Type B silica and amide-bonded silica columns. TFA use results in anion exchange properties which contrast with the cation exchange typically found with ammonium salt buffers. The significant cation exchange properties of silica hydride columns are also moderated by TFA. Similar behaviour was shown in a metal- free amide column operated on a system washed with a metal complexing agent, suggesting that adsorbed metal cations were not responsible for this anion exchange behaviour...
December 15, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28068344/an-empirical-analysis-of-rough-set-categorical-clustering-techniques
#11
Jamal Uddin, Rozaida Ghazali, Mustafa Mat Deris
Clustering a set of objects into homogeneous groups is a fundamental operation in data mining. Recently, many attentions have been put on categorical data clustering, where data objects are made up of non-numerical attributes. For categorical data clustering the rough set based approaches such as Maximum Dependency Attribute (MDA) and Maximum Significance Attribute (MSA) has outperformed their predecessor approaches like Bi-Clustering (BC), Total Roughness (TR) and Min-Min Roughness(MMR). This paper presents the limitations and issues of MDA and MSA techniques on special type of data sets where both techniques fails to select or faces difficulty in selecting their best clustering attribute...
2017: PloS One
https://www.readbyqxmd.com/read/28060892/the-utility-of-post-void-residual-volume-versus-sphincter-electromyography-to-distinguish-between-multiple-system-atrophy-and-parkinson-s-disease
#12
Tatsuya Yamamoto, Masato Asahina, Yoshitaka Yamanaka, Tomoyuki Uchiyama, Shigeki Hirano, Miki Fuse, Yasuko Koga, Ryuji Sakakibara, Satoshi Kuwabara
OBJECTIVE: To determine the ability of sphincter electromyography (EMG) and post-void residual urine volume (PVR) during a free-flow study and a pressure-flow study (PFS) for distinguishing multiple system atrophy (MSA) from Parkinson's disease (PD). METHODS: We retrospectively reviewed 241 case records; both urodynamic study and sphincter EMG were performed in patients with MSA (n = 147) and PD (n = 94). RESULTS: There was a statistically significant difference (p < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28057080/combination-of-alpha-synuclein-immunotherapy-with-anti-inflammatory-treatment-in-a-transgenic-mouse-model-of-multiple-system-atrophy
#13
Elvira Valera, Brian Spencer, Jerel A Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats, Eliezer Masliah
Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progression of MSA have yielded suboptimal results in clinical trials, and there are no efficient treatments currently available for MSA patients. We hypothesize that combining therapies targeting different aspects of the disease may lead to better clinical outcomes. To test this hypothesis, we combined the use of a single-chain antibody targeting α-syn modified for improved central nervous system penetration (CD5-D5) with an unconventional anti-inflammatory treatment (lenalidomide) in the myelin basic protein (MBP)-α-syn transgenic mouse model of MSA...
January 5, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28049681/caries-removal-by-first-year-dental-students-a-multisource-competency-assessment-strategy-for-reflective-practice
#14
Tracy L de Peralta, Vidya Ramaswamy, Elisabeta Karl, Elizabeth Van Tubergen, Mary Ellen McLean, Mark Fitzgerald
Multisource assessment (MSA) uses multiple assessors to provide feedback. Little is known about the validity of using MSA feedback for improving students' ability to self-assess in a preclinical environment. Therefore, the aim of this study was to measure the validity of using a defined reflective process involving an MSA tool for building skill in dental students' self-evaluation of caries excavation on extracted teeth. As part of this process, 104 first-year students at one U.S. dental school used a self-generated study plan (SGSP) for structured reflection on MSA feedback during the 2013-14 academic year...
January 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28045881/associations-between-low-back-pain-and-muscle-strengthening-activity-in-u-s-adults
#15
Albatool H Alnojeidi, Tammie M Johnson, Michael R Richardson, James R Churilla
STUDY DESIGN: This was a cross-sectional study. OBJECTIVE: The primary aim of the study was to examine the association between LBP and MSA among U.S. adults using gender-stratified analyses. SUMMARY OF BACKGROUND DATA: Low back pain (LBP) is a common medical condition that impacts quality of life and professional productivity and increasesthe financial burden on the healthcare system by augmenting medical treatment costs. Previous studies analyzing gender-dependent relationships between muscle-strengthening activity (MSA) and LBP have produced mixed results...
December 30, 2016: Spine
https://www.readbyqxmd.com/read/28042344/noninvasive-imaging-of-myocardial-inflammation-in-myocarditis-using-68-ga-tagged-mannosylated-human-serum-albumin-positron-emission-tomography
#16
Seung-Pyo Lee, Hyung-Jun Im, Shinae Kang, Seock-Jin Chung, Ye Seul Cho, Hyejeong Kang, Ho Seon Park, Do-Won Hwang, Jun-Bean Park, Jin-Chul Paeng, Gi-Jeong Cheon, Yun-Sang Lee, Jae Min Jeong, Yong-Jin Kim
The diagnosis of myocarditis traditionally relies on invasive endomyocardial biopsy but none of the imaging studies so far are specific for infiltration of the inflammatory cells itself. We synthesized (68)Ga-2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA) mannosylated human serum albumin (MSA) by conjugating human serum albumin with mannose, followed by conjugation with NOTA and labeling it with (68)Ga. The efficacy of (68)Ga-NOTA-MSA positron emission tomography (PET) for imaging myocardial inflammation was tested in a rat myocarditis model...
2017: Theranostics
https://www.readbyqxmd.com/read/28034624/determinants-of-denervation-independent-depletion-of-putamen-dopamine-in-parkinson-s-disease-and-multiple-system-atrophy
#17
David S Goldstein, Patti Sullivan, Courtney Holmes, Deborah C Mash, Irwin J Kopin, Yehonatan Sharabi
BACKGROUND: Severe putamen dopamine depletion characterizes Parkinson's disease (PD) and multiple system atrophy (MSA). The extent of the depletion is greater than can be accounted for by loss of nigrostriatal dopaminergic terminals alone. We used putamen tissue levels and ratios of cysteinyl and parent catechols to explore possible denervation-independent abnormalities of dopamine synthesis and fate in PD and MSA. 5-S-Cysteinyldopa (Cys-DOPA) is produced from spontaneous oxidation of DOPA and 5-S-cysteinyldopamine (Cys-DA) from spontaneous oxidation of DA...
December 15, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28011164/impact-of-sleep-apnea-syndrome-on-survival-in-patients-with-multiple-system-atrophy
#18
Olivier Flabeau, Imad Ghorayeb, Paul Perez, Aline Maillard, Jacques Taillard, Pierre Philip, Alexandra Foubert-Samier, François Tison, Wassilios G Meissner
INTRODUCTION: Sleep apnea is very frequent in multiple system atrophy (MSA) and may contribute to the poor prognosis. The aim of the present study was to prospectively assess the relation between sleep apnea and survival in 30 consecutive MSA patients recruited at the French Reference Center for MSA. METHODS: Patients with "probable" MSA according to current consensus diagnosis criteria were enrolled in this prospective cohort study. All patients received full polysomnography at baseline and were then followed for up to 4...
December 16, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28004201/autonomic-disturbances-including-impaired-hand-thermoregulation-in-multiple-system-atrophy-and-parkinson-s-disease
#19
Sarunas Augustis, Viktoras Saferis, Wolfgang H Jost
Autonomic dysfunction in multiple system atrophy (MSA) comprises cardinal symptoms of orthostatic hypotension (OH) and urinary incontinence. Additionally, cardiovagal and sudomotor abnormalities can be present. Previous studies compared hand skin temperature and its response to cooling in subjects with probable MSA and Parkinson's disease (PD). Significant differences were found indicating that disturbed thermoregulation belongs to MSA autonomic features and could be helpful in differentiation of MSA from PD...
December 21, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28002204/anesthesia-service-use-and-the-uptake-of-screening-colonoscopies
#20
Samuel Hirshman, Soeren Mattke, Hangsheng Liu
BACKGROUND: The Center for Medicare & Medicaid Services recently defined "screening colonoscopy" to include separately furnished anesthesia services. OBJECTIVE: To examine the relationship between anesthesia service use and the uptake of screening colonoscopies. STUDY DESIGN: We correlated metropolitan statistical area (MSA) level anesthesia service use rates, derived from the 2008, 2010, and 2012 Medicare and MarketScan claims data, with the presence of individual level guideline concordant screening colonoscopy using the Behavioral Risk Factor Surveillance System data for the same years...
December 20, 2016: Medical Care
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