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https://www.readbyqxmd.com/read/28808018/a-genome-tree-of-life-for-the-fungi-kingdom
#1
JaeJin Choi, Sung-Hou Kim
Fungi belong to one of the largest and most diverse kingdoms of living organisms. The evolutionary kinship within a fungal population has so far been inferred mostly from the gene-information-based trees ("gene trees"), constructed commonly based on the degree of differences of proteins or DNA sequences of a small number of highly conserved genes common among the population by a multiple sequence alignment (MSA) method. Since each gene evolves under different evolutionary pressure and time scale, it has been known that one gene tree for a population may differ from other gene trees for the same population depending on the subjective selection of the genes...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28805573/nonmotor-features-in-atypical-parkinsonism
#2
Kailash P Bhatia, Maria Stamelou
Atypical parkinsonism (AP) comprises mainly multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), which are distinct pathological entities, presenting with a wide phenotypic spectrum. The classic syndromes are now called MSA-parkinsonism (MSA-P), MSA-cerebellar type (MSA-C), Richardson's syndrome, and corticobasal syndrome. Nonmotor features in AP have been recognized almost since the initial description of these disorders; however, research has been limited...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803444/atypical-parkinsonian-syndromes-a-general-neurologist-s-perspective
#3
REVIEW
Angela B Deutschländer, Owen A Ross, Dennis W Dickson, Zbigniew K Wszolek
The differential diagnosis of atypical parkinsonian syndromes is challenging. These severe and often rapidly progressive neurodegenerative disorders are clinically heterogeneous and show significant phenotypic overlap. Here we review clinical, imaging, neuropathologic and genetic features of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and frontotemporal lobar degeneration (FTLD). The terms CBD and FTLD refer to pathologically confirmed cases of corticobasal syndrome (CBS) and frontotemporal dementia (FTD)...
August 12, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28799303/clinical-profile-of-dysphagia-in-patients-with-parkinson-s-disease-progressive-supranuclear-palsy-and-multiple-system-atrophy
#4
Sulena, Dipti Gupta, Anjani Kumar Sharma, Baltej Singh
BACKGROUND: Swallowing changes are commonly observed in Parkinson's and Parkinsonism plus syndromes. Expeditious identification is necessary to provide early intervention in this population to avoid risk of aspiration and swallowing complications. OBJECTIVE: To investigate swallowing problems using detailed case history and swallowing speed on 3 ounce water test in three groups i.e. PD, MSA and PSP groups and further, to compare it with control group. SUBJECT AND METHODS: Cross sectional study design...
August 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28797165/spontaneous-cooling-absorption-of-co2-by-a-polymeric-ionic-liquid-for-direct-air-capture
#5
Tao Wang, Chenglong Hou, Kun Ge, Klaus S Lackner, Xiaoyang Shi, Jun Liu, Mengxiang Fang, Zhongyang Luo
A polymeric ionic liquid (PIL), with quaternary ammonium ions attached to the polymer matrix, displays CO2 affinity controlled by moisture. This finding led to the development of moisture swing absorption (MSA) for direct air capture (DAC) of CO2. This work aims to elucidate the role of water in MSA. For some humidity range, CO2 absorption is an endothermic process associated with concurrent dehydration of the sorbent. The thermodynamic behavior of water indicates a decreased hydrophilicity of the PIL as the mobile anion transforms from CO32- to HCO3- during CO2 absorption...
August 10, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28794257/clinical-and-genetic-characteristics-of-sporadic-adult-onset-degenerative-ataxia
#6
Ilaria Giordano, Florian Harmuth, Heike Jacobi, Brigitte Paap, Stefan Vielhaber, Judith Machts, Ludger Schöls, Matthis Synofzik, Marc Sturm, Chantal Tallaksen, Iselin M Wedding, Sylvia Boesch, Andreas Eigentler, Bart van de Warrenburg, Judith van Gaalen, Christoph Kamm, Ales Dudesek, Jun-Suk Kang, Dagmar Timmann, Gabriella Silvestri, Marcella Masciullo, Thomas Klopstock, Christiane Neuhofer, Christos Ganos, Alessandro Filla, Peter Bauer, Sophie Tezenas du Montcel, Thomas Klockgether
OBJECTIVE: To define the clinical phenotype and natural history of sporadic adult-onset degenerative ataxia and to identify putative disease-causing mutations. METHODS: The primary measure of disease severity was the Scale for the Assessment and Rating of Ataxia (SARA). DNA samples were screened for mutations using a high-coverage ataxia-specific gene panel in combination with next-generation sequencing. RESULTS: The analysis was performed on 249 participants...
August 9, 2017: Neurology
https://www.readbyqxmd.com/read/28782850/self-correction-strategy-for-precise-massive-and-parallel-macroscopic-supramolecular-assembly
#7
Guannan Ju, Fengli Guo, Qian Zhang, Alexander J C Kuehne, Shuxun Cui, Mengjiao Cheng, Feng Shi
Macroscopic supramolecular assembly (MSA) represents a new advancement in supramolecular chemistry involving building blocks with sizes beyond tens of micrometers associating through noncovalent interactions. MSA is established as a unique method to fabricate supramolecularly assembled materials by shortening the length scale between bulk materials and building blocks. However, improving the precise alignment during assembly to form orderly assembled structures remains a challenge. Although the pretreatment of building blocks can ameliorate order to a certain degree, defects or mismatching still exists, which limits the practical applications of MSA...
August 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28782838/critical-appraisal-of-clinical-trials-in-multiple-system-atrophy-toward-better-quality
#8
REVIEW
Ana Castro Caldas, Johannes Levin, Ruth Djaldetti, Olivier Rascol, Gregor Wenning, Joaquim J Ferreira
Multiple system atrophy (MSA) is a rare neurodegenerative disease of undetermined cause. Although many clinical trials have been conducted, there is still no treatment that cures the disease or slows its progression. We sought to assess the clinical trials, methodology, and quality of reporting of clinical trails conducted in MSA patients. We conducted a systematic review of all trials with at least 1 MSA patient subject to any pharmacological/nonpharmacological interventions. Two independent reviewers evaluated the methodological characteristics and quality of reporting of trials...
August 7, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28782341/genetic-screening-for-spinocerebellar-ataxia-genes-in-a-japanese-single-hospital-cohort
#9
Ryuji Sakakibara, Fuyuki Tateno, Masahiko Kishi, Yohei Tsuyusaki, Yosuke Aiba, Hitoshi Terada, Tsutomu Inaoka, Setsu Sawai, Satoshi Kuwabara, Fumio Nomura
Objective: Diagnosis of sporadic cerebellar ataxia is a challenge for neurologists. A wide range of potential causes exist, including chronic alcohol use, multiple system atrophy of cerebellar type (MSA-C), and sporadic late cortical cerebellar atrophy. Recently, an autosomal-dominant spinocerebellar ataxia (SCA) mutation was identified in a cohort of patients with non-MSA-C sporadic cerebellar ataxia. The aim of this study is to genetically screen genes involved in SCA in a Japanese single-hospital cohort...
August 8, 2017: Journal of Movement Disorders
https://www.readbyqxmd.com/read/28779982/redox-sensitive-cationic-pullulan-for-efficient-gene-transfection-and-drug-retention-in-c6-glioma-cells
#10
Priya S S, Rekha M R
Thiolated cationic pullulan was synthesized by conjugating pullulan with polyethyleneimine (PEI) and mercaptosuccinic acid (MSA). The formed conjugate was oxidized to obtain disulfide linked cationic pullulan (PPMSS). PPMSS exhibited good buffering capacity and nanoplexes formulated were of size less than 150nm. Nanoplexes formed with PPMSS are redox sensitive and susceptible to reductive cleavage by dithiothreitol (DTT) ensuring the intracellular release of DNA. In vitro, cytotoxic evaluation studies of polymers in C6 cell lines established its non-toxic nature...
August 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28777686/a-non-parametric-item-response-theory-evaluation-of-the-cage-instrument-among-older-adults
#11
Edimansyah Abdin, Vathsala Sagayadevan, Janhavi Ajit Vaingankar, Louisa Picco, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: The validity of the CAGE using item response theory (IRT) has not yet been examined in older adult population. OBJECTIVE: This study aims to investigate the psychometric properties of the CAGE using both non-parametric and parametric IRT models, assess whether there is any differential item functioning (DIF) by age, gender and ethnicity and examine the measurement precision at the cut-off scores. METHODS: We used data from the Well-being of the Singapore Elderly study to conduct Mokken scaling analysis (MSA), dichotomous Rasch and 2-parameter logistic IRT models...
August 4, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28772443/synthesis-of-magnetic-microspheres-with-sodium-alginate-and-activated-carbon-for-removal-of-methylene-blue
#12
Chaodao Li, Jianjiang Lu, Shanman Li, Yanbin Tong, Bangce Ye
Based on the adsorption performance of composite microspheres with activated carbon (AC) and sodium alginate (SA), as well as the magnetic property of Fe₃O₄, we designed and explored an efficient strategy to prepare a unique, multifunctional Fe₃O₄/AC/SA composite absorbent (MSA-AC) that extracted dye from aqueous solution. The composite exhibited the following advantages: rapid and simple to prepare, environmentally friendly process, low-cost, recyclability, and multi-functionality. The physicochemical properties of the prepared magnetic microspheres were measured, and methylene blue (MB) was selected to investigate the performance of the magnetic absorbent...
January 20, 2017: Materials
https://www.readbyqxmd.com/read/28771723/-prion-like-propagation-of-the-synucleinopathy-of-m83-transgenic-mice-depends-on-the-mouse-genotype-and-type-of-inoculum
#13
Dorian Sargent, Jérémy Verchere, Corinne Lazizzera, Damien Gaillard, Latifa Lakhdar, Nathalie Streichenberger, Eric Morignat, Dominique Bétemps, Thierry Baron
The M83 transgenic mouse is a model of human synucleinopathies that develops severe motor impairment correlated with accumulation of the pathological Ser129-phosphorylated α-synuclein (α-syn(P) ) in the brain and spinal cord. M83 disease can be accelerated by intracerebral inoculation of brain extracts from sick M83 mice. This has also recently been described using peripheral routes, injecting recombinant preformed α-syn fibrils into the muscle or the peritoneum. Here, we inoculated homozygous and/or hemizygous M83 neonates via the intraperitoneal and/or intracerebral routes with two different brain extracts: one from sick M83 mice inoculated with brain extract from other sick M83 mice, and the other derived from a human multiple system atrophy (MSA) source passaged in M83 mice...
August 3, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28770651/multiple-system-atrophy-many-lessons-from-the-transcriptome
#14
Ashton Curry-Hyde, Bei Jun Chen, Uwe Ueberham, Thomas Arendt, Michael Janitz
Multiple system atrophy (MSA) is a complex, multifactorial, debilitating neurodegenerative disease that is often misdiagnosed and misunderstood. MSA has two subclasses, MSA-P and MSA-C, defined by the dominance of parkinsonism or cerebellar dysfunction in the earlier stages of disease, coupled with dysautonomia. This distinction between subclasses becomes largely redundant as the disease progresses. Aggregation of α-synuclein is a clinical marker used to confirm MSA diagnoses, which can only be performed postmortem...
August 1, 2017: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/28768344/determining-bilateral-strength-imbalances-in-youth-basketball-athletes
#15
Christopher Thomas, Paul Comfort, Thomas Dos'Santos, Paul A Jones
The aims of this study were: 1) to compare the strongest (D) and weakest (ND) limbs in determining muscle strength asymmetry (MSA) ratios among various muscle strength qualities and 2) to determine the relationships among various muscle strength qualities. 17 youth male basketball athletes (age=17.5±0.8 years; height=187.1±9.4 cm; body mass=81.4±10.1 kg) participated in this study. Knee flexor and extensor strength at 60°·s(-1) was assessed for both limbs with the use of isokinetic dynamometry. Other tests involved single-leg hop (SLH), countermovement jump (CMJ) and isometric mid-thigh pull (IMTP)...
September 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28762086/regional-microstructural-damage-and-patterns-of-eye-movement-impairment-a-dti-and-video-oculography-study-in-neurodegenerative-parkinsonian-syndromes
#16
Martin Gorges, Melanie N Maier, Johannes Rosskopf, Olga Vintonyak, Elmar H Pinkhardt, Albert C Ludolph, Hans-Peter Müller, Jan Kassubek
Characteristic alterations of eye movement control are a common feature of neurodegenerative parkinsonism, including Parkinson's disease (PD), progressive supranuclear palsy (PSP), and multiple system atrophy (MSA). Regional microstructural alterations as assessed by diffusion tensor imaging (DTI) have been reported in PD, PSP, and MSA. Therefore, we investigated the specific association between eye movement disturbances and microstructural impairment in these diseases. Video-oculographic recordings of smooth pursuit and visually guided reactive saccades as well as fractional anisotropy (FA) maps computed from whole-brain DTI data were analyzed for 36 PD, 30 PSP, 18 MSA patients, and 23 matched healthy control subjects...
July 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28760183/prevalence-and-factors-associated-with-smokeless-tobacco-use-2014-2016
#17
Dina M Jones, Ban A Majeed, Scott R Weaver, Kymberle Sterling, Terry F Pechacek, Michael P Eriksen
OBJECTIVES: We aimed to determine whether the prevalence of current use of smokeless tobacco products (STPs) changed during 2014-2016 and examine factors associated with use among adults in the United States (US). METHODS: Data were obtained from Tobacco Products and Risk Perceptions Surveys of probability samples representative of US adults in 2014, 2015, and 2016. Change over time in current (past 30 day) STP use was examined using pairwise comparisons of proportions and multivariable logistic regression...
September 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/28759849/mercaptosuccinic-acid-coated-nir-emitting-gold-nanoparticles-for-the-sensitive-and-selective-detection-of-hg-2
#18
Xiaodong Xiong, Xiaoqi Lai, Jinbin Liu
A sensitive fluorescent detection platform for Hg(2+) was constructed based on mercaptosuccinic acid (MSA) coated near-infrared (NIR)-emitting gold nanoparticles (AuNPs). The thiolated mercaptosuccinic acid was employed as both reducing agent and surface coating ligand in a one-step synthesis of NIR-emitting AuNPs (MSA-AuNPs), which exhibited stable fluorescence with the maximum wavelength at 800nm and a wide range of excitation (220-650nm) with the maxima at 413nm. The MSA coated NIR-emitting AuNPs showed a rapid fluorescence quenching toward Hg(2+) over other metal ions with a limit of detection (LOD, 3δ) as low as 4...
July 23, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28759740/radiological-evaluation-of-maxillary-sinus-anatomy-a-cross-sectional-study-of-300-patients
#19
Naroa Lozano-Carrascal, Oscar Salomó-Coll, Sergio Alexandre Gehrke, José Luis Calvo-Guirado, Federico Hernández-Alfaro, Jordi Gargallo-Albiol
OBJECTIVE: The aim of the present study was to evaluate the principal anatomical characteristics of the maxillary sinus using Cone Beam Computed Tomography (CBCT) in order to facilitate prevention of intra- and post-operative complications. MATERIALS AND METHODS: Three hundred CBCT scans from patients undergoing implant surgery were analysed. The following anatomical structures were evaluated: (1) Residual ridge height (RRH) and width (RRW); (2) Ridge bone density (BD); (3) Maxillary sinus angle (MSA); (4) Maxillary sinus lateral wall thickness (LWT); (5) Schneiderian membrane thickness (MT); (6) Maxillary sinus septa (SS); (7) Posterior superior alveolar artery (PSAA)...
July 29, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28748633/depression-and-anxiety-in-multiple-system-atrophy
#20
L-Y Zhang, B Cao, Y-T Zou, Q-Q Wei, R-W Ou, B Zhao, Y Wu, H-F Shang
BACKGROUND: It has been noticed that the patients with multiple system atrophy (MSA) can accompany with depression and anxiety. This study aimed to establish the incidence and determinants of depression and anxiety symptoms in Chinese MSA patients. METHODS: A total of 237 MSA patients were enrolled in the study. Neuropsychological assessment was performed using Hamilton Depression Rating Scale-24 items and Hamilton Anxiety Rating Scale. RESULTS: We found that 62...
July 26, 2017: Acta Neurologica Scandinavica
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