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https://www.readbyqxmd.com/read/29790960/complexcontact-a-web-server-for-inter-protein-contact-prediction-using-deep-learning
#1
Hong Zeng, Sheng Wang, Tianming Zhou, Feifeng Zhao, Xiufeng Li, Qing Wu, Jinbo Xu
ComplexContact (http://raptorx2.uchicago.edu/ComplexContact/) is a web server for sequence-based interfacial residue-residue contact prediction of a putative protein complex. Interfacial residue-residue contacts are critical for understanding how proteins form complex and interact at residue level. When receiving a pair of protein sequences, ComplexContact first searches for their sequence homologs and builds two paired multiple sequence alignments (MSA), then it applies co-evolution analysis and a CASP-winning deep learning (DL) method to predict interfacial contacts from paired MSAs and visualizes the prediction as an image...
May 22, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29785965/inflammatory-bowel-disease-increases-the-risk-of-parkinson-s-disease-a-danish-nationwide-cohort-study-1977-2014
#2
Marie Villumsen, Susana Aznar, Bente Pakkenberg, Tine Jess, Tomasz Brudek
OBJECTIVE: Intestinal inflammation has been suggested to play a role in development of Parkinson's disease (PD) and multiple system atrophy (MSA). To test the hypothesis that IBD is associated with risk of PD and MSA, we performed a nationwide population-based cohort study. DESIGN: The cohort consisted of all individuals diagnosed with IBD in Denmark during 1977-2014 (n=76 477) and non-IBD individuals from the general population, who were comparable in terms of gender, age and vital status (n=7 548 259)...
May 21, 2018: Gut
https://www.readbyqxmd.com/read/29783976/possible-multiple-system-atrophy-with-predominant-parkinsonism-in-a-patient-with-chronic-schizophrenia-a-case-report
#3
Hiroshi Komatsu, Masaaki Kato, Teiko Kinpara, Takashi Ono, Yoshihisa Kakuto
BACKGROUND: Multiple system atrophy (MSA) is an adult-onset, rare, and progressive neurodegenerative disorder characterized by a varying combination of autonomic failure, cerebellar ataxia, and parkinsonism. MSA is categorized as MSA-P with predominant parkinsonism, and as MSA-C with predominant cerebellar features. The prevalence of MSA has been reported to be between 1.86 and 4.9 cases per 100,000 individuals. In contrast, approximately 1% of the population is affected by schizophrenia during their lifetime; therefore, MSA-P comorbidity is very rare in schizophrenic patients...
May 21, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29783943/limited-effects-of-dysfunctional-macroautophagy-on-the-accumulation-of-extracellularly-derived-%C3%AE-synuclein-in-oligodendroglia-implications-for-msa-pathogenesis
#4
Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K Wenning, Nadia Stefanova
BACKGROUND: The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs). A connection between the abnormal accumulation of α-synuclein in GCIs and disease initiation and progression has been postulated. Mechanisms involved in the formation of GCIs are unclear. Abnormal uptake of α-synuclein from extracellular space, oligodendroglial overexpression of α-synuclein, and/or dysfunctional protein degradation including macroautophagy have all been discussed...
May 21, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29775743/redox-regulation-of-protein-kinase-c-by-selenometabolites-and-selenoprotein-thioredoxin-reductase-limits-cancer-prevention-by-selenium
#5
REVIEW
Rayudu Gopalakrishna, Usha Gundimeda, Sarah Zhou, Bui Helena, Arne Holmgren
The cancer-preventive mechanism of selenium should address the way low concentrations of selenometabolites react with cellular targets without being diffused from the sites of generation, the way selenium selectively kills tumor cells, and the intriguing U-shaped curve that is seen with dietary supplementation of selenium and cancer prevention. Protein kinase C (PKC), a receptor for tumor promoters, is well suited for this mechanism. Due to the catalytic redox cycle, low concentrations of methylselenol, a postulated active metabolite of selenium, react with the tumor-promoting lipid hydroperoxide bound to PKC to form methylseleninic acid (MSA), which selectively reacts with thiol residues present within the vicinity of the PKC catalytic domain to inactivate it...
May 15, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29774142/comparison-of-mri-and-123-i-fp-cit-spect-for-the-evaluation-of-msa-p-clinical-severity
#6
Miki Nishimori, Yoriko Murata, Hitomi Iwasa, Kana Miyatake, Michiko Tadokoro, Shino Kohsaki, Munenobu Nogami, Norihiko Hamada, Hitoshi Ninomiya, Yasushi Osaki, Hirokazu Furuya, Takuji Yamagami
The aim of the present study was to compare the efficacy of magnetic resonance imaging (MRI) and 123 I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane single photon emission computed tomography (123 I-FP-CIT SPECT) for determining the clinical severity of patients with multiple system atrophy with Parkinsonism (MSA-P). MRI and 123 I-FP-CIT SPECT images from 17 patients with MSA-P as diagnosed using the Unified MSA Rating Scale part IV (UMSARS IV) score were compared. Brain MRI scans were available for all 17 patients and 123 I-FP-CIT SPECT images were available for 12 patients...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29771363/multiple-sequence-alignment-averaging-improves-phylogeny-reconstruction
#7
Haim Ashkenazy, Itamar Sela, Eli Levy Karin, Giddy Landan, Tal Pupko
The classic methodology of inferring a phylogenetic tree from sequence data is composed of two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is reconstructed assuming the MSA is correct. Yet, inferred MSAs were shown to be inaccurate and alignment errors reduce tree inference accuracy. It was previously proposed that filtering unreliable alignment regions can increase the accuracy of tree inference. However, it was also demonstrated that the benefit of this filtering is often obscured by the resulting loss of phylogenetic signal...
May 15, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29770925/esophageal-magnetic-sphincter-augmentation-as-a-novel-approach-to-post-bariatric-surgery-gastroesophageal-reflux-disease
#8
John P Kuckelman, Cody J Phillips, Michael J Derickson, Byron J Faler, Matthew J Martin
BACKGROUND: We sought to evaluate the safety and effectiveness of magnetic sphincter augmentation (MSA) in patients with GERD after bariatric surgery. METHODS: Pre- and post-operative GERD quality of life (G-QOL) surveys were conducted. Standard indications (SI) group or the post-bariatric group (PB) created. Outcomes were compared between groups. RESULTS: Twenty-eight patients analyzed with no losses to follow-up. All patients had preoperative testing confirming normal motility and presence of GERD...
May 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29770465/expression-of-myxovirus-resistance-protein-a-a-possible-marker-of-muscle-disease-activity-and-autoantibody-specificities-in-juvenile-dermatomyositis
#9
Sirisucha Soponkanaporn, Claire T Deakin, Peter W Schutz, Lucy R Marshall, Shireena A Yasin, Cerise M Johnson, Erdal Sag, Sarah L Tansley, Neil J McHugh, Lucy R Wedderburn, Thomas S Jacques
AIMS: To evaluate the relationship between expression of Myxovirus-resistance protein A (MxA) protein on muscle biopsies by immunohistochemistry and disease activity in JDM patients. Also, another aim was to investigate whether the expression of MxA is related with myositis-specific autoantibodies (MSA) status in JDM patients. METHODS: 103 patients (median aged 6.3, IQR 0.5-15.9) enrolled in the Juvenile Dermatomyositis Cohort and Biomarker Study (JDCBS). Muscle biopsies were stained with MxA and scored...
May 16, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29768891/effect-of-mercaptosuccinic-acid-stabilizer-agent-on-the-optical-properties-of-colloidal-cdte-quantum-dots
#10
J C L Sousa, M G Vivas, B R C Vale, J L Ferrari, D M A Schiavon
In the present work, we report on the positive effect of mercaptosuccinic acid (MSA) stabilizer agent on the optical features of colloidal CdTe quantum dots (QDs). With this aim, we performed some spectroscopic measurements such as steady-state absorption and fluorescence, fluorescence quantum yield and time-resolved photoluminescence for five MSA-capped CdTe QD samples with different synthesis times. The first general aspect to highlight is that the QDs' average size increased with synthesis time (from 30 to 150 min) while the size dispersion decreased due to the Ostwald ripening mechanism...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768596/sociodemographic-and-environmental-analysis-for-the-occurrence-of-anti-leptospira-antibodies-in-dogs-of-teresina-piau%C3%A3-brazil
#11
Elís Rosélia Dutra de Freitas Siqueira Silva, Vanessa Castro, Ana Lys Bezerra Barradas Mineiro, Maria das Graças Prianti, Gustavo Henrique Chaves Martins, Misael das Virgens Santana, Lucas Moreira Brito, Silvana Maria Medeiros de Sousa Silva
Leptospirosis is a worldwide zoonosis whose transmission is interlinked by multiple factors in the man-animal-ecosystem interface. This study aimed to evaluate the risk factors for the occurrence of anti-Leptospira antibodies in dogs in the capital Teresina (PI), and to determine their spatial distribution. Five hundred fifty-eight dog blood samples were submitted to the Microscopic Serum Agglutination (MSA) test. We applied semi-structured questionnaires to dog owners and obtained the area of residence for projection in geographical maps...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29767310/the-removal-of-silver-nanoparticle-by-titanium-tetrachloride-and-modified-sodium-alginate-composite-coagulants-floc-properties-membrane-fouling-and-floc-recycle
#12
Ziyang Wang, Yan Wang, Cong Yu, Yanxia Zhao, Meixia Fan, Baoyu Gao
In this study, a modified sodium alginate (MSA) composited with TiCl4 was used to treat the synthetic Ag nanoparticles (AgNPs) water in coagulation-ultrafiltration process. The floc properties and membrane fouling of TiCl4 and MSA composite coagulants (TiCl4 + MSA) were investigated by a laser diffraction instrument and ultrafiltration fouling model. The recycle of the AgNP-containing flocs was evaluated by XRD and photocatalytic experiments. The results showed that TiCl4 + MSA could achieve better coagulation performance than TiCl4 alone with AgNP and DOC removal up to 97 and 59% at the optimum condition (pH = 5 and dosage = 12 mg TiCl4 /L)...
May 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29765223/efficacy-of-denosumab-in-two-cases-with-multiple-system-atrophy-and-osteoporosis
#13
Masashi Uehara, Yukio Nakamura, Jun Takahashi, Takako Suzuki, Hiroyuki Kato
Background: Multiple-system atrophy (MSA) is an α-synucleinopathy with a very aggressive course and poor prognosis, which lacks efficient treatment. Thus, MSA represents a serious health and social problem. Progressive stridor and acute laryngeal obstruction likely occur in MSA; however, little is known about the bone metabolism or efficacy of bone absorption drugs, such as denosumab, in osteoporosis with MSA. Case presentation and methods: Two male patients with osteoporosis in MSA presented to our institution (at 54 and 68 years of age)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29764386/parkinson-s-disease-diagnostic-observations-paddo-study-rationale-and-design-of-a-prospective-cohort-study-for-early-differentiation-of-parkinsonism
#14
Anouke van Rumund, Marjolein B Aerts, Rianne A J Esselink, Frederick J A Meijer, Marcel M Verbeek, Bastiaan R Bloem
BACKGROUND: Differentiation of Parkinson's disease (PD) from the various types of atypical parkinsonism (AP) such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), dementia with Lewy bodies (DLB), corticobasal syndrome (CBS) and vascular parkinsonism (VP), can be challenging, especially early in the disease course when symptoms overlap. A major unmet need in the diagnostic workup of these disorders is a diagnostic tool that differentiates the various disorders, preferably in the earliest disease stages when the clinical presentation is similar...
May 16, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29756231/susceptibility-mri-captures-nigral-pathology-in-patients-with-parkinsonian-syndromes
#15
Mechelle M Lewis, Guangwei Du, Jennifer Baccon, Amanda M Snyder, Ben Murie, Felicia Cooper, Christy Stetter, Lan Kong, Christopher Sica, Richard B Mailman, James R Connor, Xuemei Huang
BACKGROUND: Parkinsonisms are neurodegenerative disorders characterized pathologically by α-synuclein-positive (e.g., PD, diffuse Lewy body disease, and MSA) and/or tau-positive (e.g., PSP, cortical basal degeneration) pathology. Using R2* and quantitative susceptibility mapping, susceptibility changes have been reported in the midbrain of living parkinsonian patients, although the exact underlying pathology of these alterations is unknown. OBJECTIVE: The current study investigated the pathological correlates of these susceptibility MRI measures...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29749034/macroscopic-supramolecular-assembly-through-electrostatic-interactions-based-on-a-flexible-spacing-coating
#16
Qian Zhang, Chongxian Liu, Guannan Ju, Mengjiao Cheng, Feng Shi
Macroscopic supramolecular assembly (MSA) is a recent advance in supramolecular chemistry that involves associating large building blocks with a size larger than 10 µm through noncovalent interactions. However, until now the applicable material system is rather limited to hydrogels, and MSA of rigid materials with supramolecular interactions widely used in molecular assembly has rarely been reported due to the difficulty in achieving multivalency between rigid surfaces. Herein, the concept of flexible spacing coating is applied with highly flowable properties, and the electrostatic-interaction-driven MSA of relatively rigid polydimethylsiloxane building blocks is demonstrated...
May 11, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29746401/progressive-supranuclear-palsy-and-multiple-system-atrophy-clinicopathological-concepts-and-therapeutic-challenges
#17
Gesine Respondek, Johannes Levin, Günter U Höglinger
PURPOSE OF REVIEW: This update discusses novel aspects on clinicopathological concepts and therapeutic challenges in progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), arising from publications of the last 1.5 years. RECENT FINDINGS: The clinical criteria for diagnosis of PSP have been revised. Clinical variability of pathologically defined PSP and MSA makes the development of mature biomarkers for early diagnosis and biomarker-based trial design indispensable...
May 8, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29743599/crural-closure-improves-outcomes-of-magnetic-sphincter-augmentation-in-gerd-patients-with-hiatal-hernia
#18
Katrin Schwameis, Milena Nikolic, Deivis G Morales Castellano, Ariane Steindl, Sarah Macheck, M Riegler, Ivan Kristo, Barbara Zörner, Sebastian F Schoppmann
Magnetic sphincter-augmentation (MSA) has been proven effective in the treatment of GERD. No consensus exists on whether crural closure should be performed. Our aim was to assess the impact of cruroplasty on reflux-control and quality of life. MSA-Patients treated between 03/2012-03/2017 were classified into those without hiatal hernia ("NHH"), those post-MSA (NHR) and those post-MSA/hiatal repair (HR). GERD-symptoms, PPI-intake, GERD-Health-related-Quality-of-Life (GERD-HRQL) and Alimentary Satisfaction were assessed...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741613/lysosomal-storage-disorder-gene-variants-in-multiple-system-atrophy
#19
Lasse Pihlstrøm, Lucia Schottlaender, Viorica Chelban, Wassilios G Meissner, Monica Federoff, Andy Singleton, Henry Houlden
No abstract text is available yet for this article.
May 7, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29740770/characteristics-and-batch-experiments-of-acid-and-alkali-modified-corncob-biomass-for-nitrate-removal-from-aqueous-solution
#20
Xiaolan Hu, Yingwen Xue, Li Long, Kejing Zhang
In this study, modified biochar was adopted as an adsorbent for the nitrate removal in aqueous solutions. Raw material was impregnated in sulfuric acid (H2 SO4 , 1 mol/L) and sodium hydroxide (NaOH, 2 mol/L) separately and then prepared at 600 °C. After treated with acid, the BET specific surface area was much higher than that of unmodified and alkali-modified biochars. The low adsorption capacity and specific surface area of alkali-modified biochar may be due to the precipitate on the surface according to the results of XRD...
May 9, 2018: Environmental Science and Pollution Research International
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