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https://www.readbyqxmd.com/read/29456843/analysis-of-selected-policies-towards-universal-health-coverage-in-uganda-the-policy-implementation-barometer-protocol
#1
Charles Hongoro, Elizeus Rutebemberwa, Thembinkosi Twalo, Chikondi Mwendera, Mbuyiselo Douglas, Moses Mukuru, Simon Kasasa, Freddie Ssengooba
Background: Policy implementation remains an under researched area in most low and middle income countries and it is not surprising that several policies are implemented without a systematic follow up of why and how they are working or failing. This study is part of a larger project called Supporting Policy Engagement for Evidence-based Decisions (SPEED) for Universal Health Coverage in Uganda. It seeks to support policymakers monitor the implementation of vital programmes for the realisation of policy goals for Universal Health Coverage...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29456806/women-with-hereditary-breast-cancer-predispositions-should-avoid-using-their-smartphones-tablets-and-laptops-at-night
#2
EDITORIAL
Seyed Ali Reza Mortazavi, Seyed Mohammad Javad Mortazavi
Breast cancer is the most common malignancy among women, both in the developed and developing countries. Women with mutations in the BRCA1 and BRCA2 genes have an increased risk of breast and ovarian cancers. Recent studies show that short-wavelength visible light disturb the secretion of melatonin and causes circadian rhythm disruption. We have previously studied the health effects of exposure to different levels of radiofrequency electromagnetic fields (RF-EMFs) such as mobile phones, mobile base stations, mobile phone jammers, laptop computers, and radars...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29454220/early-life-sexual-abuse-is-associated-with-increased-suicide-attempts-an-update-meta-analysis
#3
REVIEW
Qin Xiang Ng, Bob Zheng Jie Yong, Collin Yin Xian Ho, Donovan Yutong Lim, Wee-Song Yeo
Suicide is an emerging, yet preventable global health issue associated with significant mortality. Identification of underlying risk factors and antecedents may inform preventive strategies and interventions. This study serves to provide an updated meta-analysis examining the extent of association of early life sexual abuse with suicide attempts. Using the keywords [early abuse OR childhood abuse OR sexual OR rape OR molest* OR violence OR trauma OR PTSD] AND [suicid* OR premature OR unnatural OR deceased OR died OR mortality], a preliminary search on the PubMed, Ovid, PsychINFO, Web of Science and Google Scholar databases yielded 12,874 papers published in English between 1-Jan-1988 and 1-June-2017...
February 6, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29453368/effects-of-timber-harvesting-on-the-genetic-potential-for-carbon-and-nitrogen-cycling-in-five-north-american-forest-ecozones
#4
Erick Cardenas, Luis H Orellana, Konstantinos T Konstantinidis, William W Mohn
Forest ecosystems are critical to global biogeochemical cycles but under pressure from harvesting and climate change. We investigated the effects of organic matter (OM) removal during forest harvesting on the genetic potential of soil communities for biomass decomposition and nitrogen cycling in five ecozones across North America. We analyzed 107 samples, representing four treatments with varied levels of OM removal, at Long-Term Soil Productivity Study sites. Samples were collected more than ten years after harvesting and replanting and were analyzed via shotgun metagenomics...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29451694/children-with-facial-morphea-managing-everyday-life-a-qualitative-study
#5
E Stasiulis, B Gladstone, K Boydell, C O'Brien, E Pope, R Laxer
BACKGROUND: This study explores the everyday experiences of children with facial morphea by examining the psychosocial impact of living with facial morphea and how children and their families manage its impact. METHODS: We used a qualitative, social constructionist approach involving focus groups, in-depth interviews and drawing activities with 10 children with facial morphea 8-17 years of age and 13 parents. Interpretive thematic analysis was utilized to examine the data...
February 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29451670/-it-s-a-traumatic-illness-traumatic-to-witness-a-qualitative-study-of-the-experiences-of-bereaved-family-caregivers-of-patients-with-cutaneous-t-cell-lymphoma
#6
D Orlowska, L E Selman, T Beynon, E Radcliffe, S Whittaker, F Child, R Harding
BACKGROUND: Cutaneous T-cell lymphomas (CTCL) are rare cancers which can be difficult to diagnose, are incurable and adversely affect quality of life, particularly in advanced disease. Families often provide care, but little is known about their experiences or needs while caring for their relative with advanced disease or in bereavement. OBJECTIVES: To explore the experiences of bereaved family caregivers of patients with CTCL. METHODS: Single semi-structured qualitative interviews were conducted with bereaved family caregivers of patients with CTCL recruited via a supra-regional CTCL clinic...
February 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29446969/age-related-changes-in-emotional-qualities-of-the-social-network-from-middle-adulthood-into-old-age-how-do-they-relate-to-the-experience-of-loneliness
#7
Anne Böger, Oliver Huxhold
Research shows that people maintain fewer social ties and social activities when they grow older. There appears, however, to be little variation in the average loneliness level from middle adulthood into old age. In this study we investigate to what extent beneficial changes in emotional qualities of the social network (SNW; number of distressing relationships, number of pleasant relationships, relationship satisfaction) may help to prevent an age-related increase in loneliness. We concentrate in particular on the question as to whether these emotional qualities become more relevant for predicting loneliness when people grow older...
February 15, 2018: Psychology and Aging
https://www.readbyqxmd.com/read/29446509/recovery-without-autonomy-progress-forward-or-more-of-the-same-for-mental-health-service-users
#8
Louise Byrne, Stephanie Schoeppe, Julie Bradshaw
In Western nations, the Recovery approach has become a widely accepted philosophy and treatment concept in mental health. Yet, community understanding of the Recovery approach remains largely unexplored. This study aimed to investigate (i) people's awareness of the principles underpinning the Recovery approach in mental health, and (ii) the treatment approaches people consider most important, and whether these align with the Recovery approach. To achieve these aims, a random sample of 1217 Australian adults participated in the National Social Survey (QSS) via telephone interview...
February 15, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29444678/the-wild-taxa-utilized-as-vegetables-in-sicily-italy-a-traditional-component-of-the-mediterranean-diet
#9
Anna Geraci, Filippo Amato, Giuseppe Di Noto, Giuseppe Bazan, Rosario Schicchi
BACKGROUND: Wild vegetables in the Mediterranean Basin are still often consumed as a part of the diet and, in particular, there is a great tradition regarding their use in Sicily. In this study, an ethnobotanical field investigation was carried out to (a) identify the wild native taxa traditionally gathered and consumed as vegetables in Sicily, comparing the collected ethnobotanical data with those of other countries that have nominated the Mediterranean diet for inclusion in the UNESCO Representative List of the Intangible Cultural Heritage of Humanity and (b) highlight new culinary uses of these plants...
February 14, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29444168/identifying-genetic-risk-loci-for-diabetic-complications-and-showing-evidence-for-heterogeneity-of-type-1-diabetes-based-on-complications-risk
#10
Nandita Mukhopadhyay, Janelle A Noble, Manika Govil, Mary L Marazita, David A Greenberg
There is a growing body of evidence suggesting that type 1 diabetes (T1D) is a genetically heterogeneous disease. However, the extent of this heterogeneity, and what observations may distinguish different forms, is unclear. One indicator may be T1D-related microvascular complications (MVCs), which are familial, but occur in some families, and not others. We tested the hypothesis that T1D plus MVC is genetically distinct from T1D without MCV. We studied 415 families (2,462 individuals, 896 with T1D) using genome-wide linkage analysis, comparing families with and without MVC...
2018: PloS One
https://www.readbyqxmd.com/read/29439288/childhood-pneumothorax-in-birt-hogg-dub%C3%A3-syndrome-a-cohort-study-and-review-of-the-literature
#11
Marianne Geilswijk, Elisabeth Bendstrup, Mia Gebauer Madsen, Mette Sommerlund, Anne-Bine Skytte
BACKGROUND: Birt-Hogg-Dubé syndrome (BHD) is an autosomal dominantly inherited cancer predisposition syndrome associated with an increased risk of spontaneous pneumothorax (SP) and renal cell carcinoma in the adult population. Recent studies suggest that BHD accounts for up to 10% of all SP in adults and BHD in children with SP have been reported. METHODS: To explore to what extent BHD is the cause of childhood pneumothorax, we studied a Danish BHD cohort consisting of 109 cases from 22 families...
February 13, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29438395/recognition-of-sites-of-functional-specialisation-in-all-known-eukaryotic-protein-kinase-families
#12
Raju Kalaivani, Raju Reema, Narayanaswamy Srinivasan
The conserved function of protein phosphorylation, catalysed by members of protein kinase superfamily, is regulated in different ways in different kinase families. Further, differences in activating triggers, cellular localisation, domain architecture and substrate specificity between kinase families are also well known. While the transfer of γ-phosphate from ATP to the hydroxyl group of Ser/Thr/Tyr is mediated by a conserved Asp, the characteristic functional and regulatory sites are specialized at the level of families or sub-families...
February 13, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29434420/smoking-related-stigma-expressed-by-physiotherapists-toward-individuals-with-lung-disease
#13
Bethany Bass, Elizabeth Lake, Chelsea Elvy, Sarah Fodemesi, Mara Iacoe, Emilie Mazik, Dina Brooks, Annemarie Lee
Purpose: We determined the extent and nature of stigma exhibited by a sample of Canadian cardiorespiratory physiotherapists toward people with lung disease who had a smoking history. Method: A quantitative online survey was distributed to Canadian cardiorespiratory physiotherapists, and an anti-smoking attitudes questionnaire was used to measure explicit stigma. We used two case studies with questions to measure implicit stigma. The first involved a patient with chronic obstructive pulmonary disease (COPD) and a smoking history, and the second described a patient with COPD with no smoking history...
2018: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/29433825/risk-factors-for-prostate-cancer-a-multifactorial-case-control-study
#14
Saima Shakil Malik, Rakshanda Batool, Nosheen Masood, Azra Yasmin
Prostate cancer is the third most commonly diagnosed cancer among Pakistani men. It is a multifactorial disease involving genetics together with environmental factors. Countries where men have greater dietary fat intake showed increased prostate cancer mortality rates. A population based case-control study was conducted to evaluate various prostate cancer risk factors. Study subjects were 896 prostate cancer cases (2010-2015) and 900 age matched controls. Odds ratio (OR) and 95% CI were used to estimate the association between different risk factors and prostate cancer...
February 9, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29433196/trait-anxiety-and-self-concept-among-children-and-adolescents-with-food-neophobia
#15
Edurne Maiz, Nekane Balluerka
Food problems in children and adolescents often have a detrimental effect on the emotional and psychological wellbeing of their parents. However, the impact of such problems on the psychological wellbeing of children and adolescents themselves has been less widely studied. The purpose of this study was to determine whether children and adolescents with food neophobia differed in trait anxiety and dimensions of self-concept from their neophilic and their average peers. A community sample of 831 participants (368 males and 463 females) between the ages of 8 and 16 were classified into six groups based on scores obtained on the Spanish Child Food Neophobia Scale (i...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29432786/oleic-acid-induces-the-novel-apolipoprotein-o-and-reduces-mitochondrial-membrane-potential-in-chicken-and-human-hepatoma-cells
#16
Anna M Weijler, Barbara Schmidinger, Stylianos Kapiotis, Hilde Laggner, Marcela Hermann
Non-alcoholic fatty liver disease (NAFLD) is marked by hepatic fat accumulation and reflects a spectrum of chronic liver diseases associated with obesity, impaired insulin sensitivity and dyslipidemia. Apolipoprotein O (ApoO) is a new member of the plasma apolipoprotein family that may play a role in lipid metabolism and electron transport activity of the mitochondrium. However, its physiological functions have not been elucidated yet. Based on our previous data in a non-mammalian experimental system [1], we hypothesized that hepatic expression of ApoO is tightly linked not only to diet-induced hepatosteatosis, but also to increased lipoprotein-production induced by, e...
February 9, 2018: Biochimie
https://www.readbyqxmd.com/read/29430173/exploring-the-experiences-of-older-chinese-adults-with-comorbidities-including-diabetes-surmounting-these-challenges-in-order-to-live-a-normal-life
#17
Hsiu-Yu Ho, Mei-Hui Chen, Meei-Fang Lou
Background: Many people with diabetes have comorbidities, even multimorbidities, which have a far-reaching impact on the older adults, their family, and society. However, little is known of the experience of older adults living with comorbidities that include diabetes. Aim: The aim of this study was to explore the experience of older adults living with comorbidities including diabetes. Methods: A qualitative approach was employed. Data were collected from a selected field of 12 patients with diabetes mellitus in a medical center in northern Taiwan...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29427756/crispr-cas9-ablation-of-individual-mirnas-from-a-mirna-family-reveals-their-individual-efficacies-for-regulating-cardiac-differentiation
#18
Ziyao Zhang, Rebecca Ursin, Samiksha Mahapatra, G Ian Gallicano
Although it is well understood that genetic mutations, chromosomal abnormalities, and epigenetic miscues can cause congenital birth defects, many defects are still labeled idiopathic, meaning their origin is not yet understood. microRNAs are quickly entering the causal fray of developmental defects. miRNAs use a 7-8 base-pair seed sequence to target a corresponding sequence on one or multiple mRNAs resulting in rapid down-regulation of translation. miRNAs can also control protein 'amounts' in cells. As a result if miRNAs are over or under expressed during development protein homeostasis can be compromised resulting in defects in the development of organ systems...
February 7, 2018: Mechanisms of Development
https://www.readbyqxmd.com/read/29426877/zfp36l1-and-zfp36l2-inhibit-cell-proliferation-in-a-cyclin-d-dependent-and-p53-independent-manner
#19
Fat-Moon Suk, Chi-Ching Chang, Ren-Jye Lin, Shyr-Yi Lin, Shih-Chen Liu, Chia-Feng Jau, Yu-Chih Liang
ZFP36 family members include ZFP36, ZFP36L1, and ZFP36L2, which belong to CCCH-type zinc finger proteins with two tandem zinc finger (TZF) regions. Whether ZFP36L1 and ZFP36L2 have antiproliferative activities similar to that of ZFP36 is unclear. In this study, when ZFP36L1 or ZFP36L2 was overexpressed in T-REx-293 cells, cell proliferation was dramatically inhibited and the cell cycle was arrested at the G1 phase. The levels of cell-cycle-related proteins, including cyclin B, cyclin D, cyclin A, and p21, decreased; however, p53 increased in ZFP36L1-or ZFP36L2-overexpressing T-REx-293 cells...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29426649/rest-and-stress-longitudinal-systolic-left-ventricular-mechanics-in-hypertrophic-cardiomyopathy-implications-for-prognostication
#20
Iraklis Pozios, Aurelio Pinheiro, Celia Corona-Villalobos, Lars L Sorensen, Zeina Dardari, Hong-Yun Liu, Kenneth Cresswell, Susan Phillip, David A Bluemke, Stefan L Zimmerman, M Roselle Abraham, Theodore P Abraham
BACKGROUND: Exercise intolerance is the most common symptom in hypertrophic cardiomyopathy (HCM). We examined whether inability to augment myocardial mechanics during exercise would influence functional performance and clinical outcomes in HCM. METHODS: Ninety-five HCM patients (32 nonobstructive, 32 labile-obstructive, 31 obstructive) and 26 controls of similar age and gender distribution were recruited prospectively. They underwent rest and treadmill stress strain echocardiography, and 61 of them underwent magnetic resonance imaging...
February 6, 2018: Journal of the American Society of Echocardiography
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