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https://www.readbyqxmd.com/read/29055288/osteoinductive-effects-of-cyplexinol-in-the-management-of-osteoporosis-a-case-series
#1
Daniel Tripodi
Aims • A case study was conducted on a subject with a history of documented bone loss and the observed outcome of bone mineral density (BMD) changes when utilizing supplementation with Cyplexinol, a natural bone morphogenetic protein complex. Method and Results • A case of osteoporosis was reviewed with pertinent medical history and dual energy X-ray absorptiometry history described both pre- and postsupplementation. Results demonstrated a significant change in bone density parameter for the individual when the bone support supplement, Cyplexinol, was used...
October 21, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29054340/the-transmission-of-family-food-and-mealtime-practices-from-adolescence-to-adulthood-longitudinal-findings-from-project-eat-iv
#2
Allison Watts, Jerica M Berge, Katie Loth, Nicole Larson, Dianne Neumark-Sztainer
OBJECTIVE: To determine whether family food and mealtime practices experienced in adolescence are carried forward into parenthood. DESIGN: Baseline (Project Eating and Activity in Teens and Young Adults [EAT]-I) and 15-year follow-up (EAT-IV) survey data from a population-based cohort study (Project EAT). PARTICIPANTS: Cohort members identified as parents at follow-up (n = 727). To gain additional data about the practices of both parents in the household, significant others completed surveys at EAT-IV (n = 380)...
October 17, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29053145/geometagenomics-illuminates-the-impact-of-agriculture-on-the-distribution-and-prevalence-of-plant-viruses-at-the-ecosystem-scale
#3
Pauline Bernardo, Tristan Charles-Dominique, Mohamed Barakat, Philippe Ortet, Emmanuel Fernandez, Denis Filloux, Penelope Hartnady, Tony A Rebelo, Stephen R Cousins, François Mesleard, Damien Cohez, Nicole Yavercovski, Arvind Varsani, Gordon W Harkins, Michel Peterschmitt, Carolyn M Malmstrom, Darren P Martin, Philippe Roumagnac
Disease emergence events regularly result from human activities such as agriculture, which frequently brings large populations of genetically uniform hosts into contact with potential pathogens. Although viruses cause nearly 50% of emerging plant diseases, there is little systematic information about virus distribution across agro-ecological interfaces and large gaps in understanding of virus diversity in nature. Here we applied a novel landscape-scale geometagenomics approach to examine relationships between agricultural land use and distributions of plant-associated viruses in two Mediterranean-climate biodiversity hotspots (Western Cape region of South Africa and Rhône river delta region of France)...
October 20, 2017: ISME Journal
https://www.readbyqxmd.com/read/29052957/implementing-a-family-inclusive-practice-model-in-youth-mental-health-services-in-australia
#4
Abner Weng Cheong Poon, Carol Harvey, Suzanne Fuzzard, Brendan O'Hanlon
AIM: A brief family-inclusive practice model, single session family consultation (SSFC), was introduced at 4 youth mental health service sites to determine the extent to which the model could be implemented in this context and its acceptability as a means of engaging families of young people. METHODS: Within an action research paradigm, both quantitative and qualitative measures were used for this implementation project with the former reported here. There were 2 components: (1) evaluation of the experiences of young people and their families and (2) evaluation of the extent of implementation of SSFC...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29051429/fish-reproduction-is-disrupted-upon-lifelong-exposure-to-environmental-pahs-fractions-revealing-different-modes-of-action
#5
Caroline Vignet, Thibaut Larcher, Blandine Davail, Lucette Joassard, Karyn Le Menach, Tiphaine Guionnet, Laura Lyphout, Mireille Ledevin, Manon Goubeau, Hélène Budzinski, Marie-Laure Bégout, Xavier Cousin
Polycyclic aromatic hydrocarbons (PAHs) constitute a large family of organic pollutants emitted in the environment as complex mixtures, the compositions of which depend on origin. Among a wide range of physiological defects, PAHs are suspected to be involved in disruption of reproduction. In an aquatic environment, the trophic route is an important source of chronic exposure to PAHs. Here, we performed trophic exposure of zebrafish to three fractions of different origin, one pyrolytic and two petrogenic. Produced diets contained PAHs at environmental concentrations...
October 28, 2016: Toxics
https://www.readbyqxmd.com/read/29050315/the-activation-of-src-family-kinases-and-focal-adhesion-kinase-with-the-loss-of-the-amplified-mutated-egfr-gene-contributes-to-the-resistance-to-afatinib-erlotinib-and-osimertinib-in-human-lung-cancer-cells
#6
Yuichi Murakami, Kahori Sonoda, Hideyuki Abe, Kosuke Watari, Daiki Kusakabe, Koichi Azuma, Akihiko Kawahara, Jun Akiba, Chitose Oneyama, Jonathan A Pachter, Kazuko Sakai, Kazuto Nishio, Michihiko Kuwano, Mayumi Ono
Second- and third-generation inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase activity (EGFR-TKIs) are improving the treatment of patients with non-small cell lung cancer. Here we established two sublines (BR1-8 and BR2-3) resistant to a second-generation inhibitor, afatinib, from the human lung cancer cell line HCC827 that harbors a mutation that activates the tyrosine kinase activity of EGFR. These afatinib-resistant sublines were resistant to first-generation EGFR-TKIs, gefitinib and erlotinib, and a third-generation EGFR-TKI, osimertinib...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048261/postpartum-mothers-leisure-time-exercise-behavior-is-linked-to-positive-emotion-during-partner-discussions
#7
Rachel L Hutt, Ginger A Moore, Micah A Mammen, Danielle Symons Downs
PURPOSE: Marital dissatisfaction and conflict often increase for couples after the birth of a child and are evident in fewer positive family interactions and more negative family interactions. Because exercise is known to increase positive emotions and decrease negative emotions, the current study examined the extent to which higher levels of mothers' exercise during the postpartum period were related to more positive and fewer negative emotion-expressive behaviors with their infants' fathers...
October 19, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/29046965/mother-infant-bonding-in-the-postpartum-period-assessment-of-the-impact-of-pre-delivery-factors-in-a-clinical-sample
#8
Borja Farré-Sender, Anna Torres, Estel Gelabert, Susana Andrés, Alba Roca, Gracia Lasheras, Manuel Valdés, Lluïsa Garcia-Esteve
This study aims to examine the extent to which a variety of pre-delivery factors (demographic, reproductive, psychological, psychiatric, and psychopathological) predict disturbances in mother-infant bonding (MIB) in the postpartum period. Two hundred fifty-one pregnant women enrolled at a public perinatal psychiatric service were assessed between the first and second trimester of pregnancy and at 6-7 weeks after delivery. During pregnancy, the psychological risk factors were assessed with the Vulnerable Personality Style Questionnaire, the Marital Adjustment Scale, the Early Trauma Inventory, and the General Health Questionnaire...
October 18, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29046455/extended-synaptotagmin-1-interacts-with-the-herpes-simplex-virus-type-1-glycoprotein-m-and-negatively-modulates-virus-induced-membrane-fusion
#9
Imane El Kasmi, Bita Khadivjam, Miki Lackman, Johanne Duron, Eric Bonneil, Pierre Thibault, Roger Lippé
Enveloped viruses typically encode their own fusion machinery to enter cells. Herpesviruses are particular as they fuse with a number of cellular compartments throughout their life cycle. As the uncontrolled mixing of the host membranes should be avoided in these events, the tight regulation of the viral fusion machinery is critical. While studying the herpes simplex virus type 1 glycoprotein gM, we identified the cellular protein E-Syt1 (Extended synaptotagmin-1) as an interaction partner. This took place in both infected and transfected cells, suggesting other viral proteins were not required for this interaction...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29045434/opportunities-challenges-and-systems-requirements-for-developing-post-abortion-family-planning-services-perceptions-of-service-stakeholders-in-china
#10
Hong Jiang, Jieshuang Xu, Esther Richards, Xu Qian, Weihong Zhang, Lina Hu, Shangchun Wu, Rachel Tolhurst
Post-abortion family planning (PAFP) has been proposed as a key strategy to decrease unintended pregnancy and repeat induced abortions. However, the accessibility and quality of PAFP services remain a challenge in many countries including China where more than 10 million unintended pregnancies occur each year. Most of these unwanted pregnancies end in repeated induced abortions. This paper aims to explore service providers' perceptions of the current situation regarding family planning and abortion service needs, provision, utilization, and the feasibility and acceptability of high quality PAFP in the future...
2017: PloS One
https://www.readbyqxmd.com/read/29042578/%C3%AE-defensin-1-expression-in-hcv-infected-liver-liver-cancer-an-important-role-in-protecting-hcv-progression-and-liver-cancer-development
#11
Yue-Ming Ling, Jin-Yu Chen, Libin Guo, Chen-Yi Wang, Wen-Ting Tan, Qing Wen, Shu-Dong Zhang, Guo-Hong Deng, Yao Lin, Hang Fai Kwok
β-defensin family plays a role in host defense against viral infection, however its role in HCV infection is still unknown. In this study, we demonstrated that β-defensin 1 was significantly reduced in HCV-infected liver specimens. Treatment with interferon and ribavirin upregulated β-defensin-1, but not other β-defensin tested, with the extent and duration of upregulation associated with treatment response. We investigated β-defensin family expression in liver cancer in publicly available datasets and found that among all the β-defensins tested, only β-defensin 1 was significantly downregulated, suggesting β-defensin 1 plays a crucial role in liver cancer development...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042509/properties-of-real-metallic-surfaces-effects-of-density-functional-semilocality-and-van-der-waals-nonlocality
#12
Abhirup Patra, Jefferson E Bates, Jianwei Sun, John P Perdew
We have computed the surface energies, work functions, and interlayer surface relaxations of clean (111), (100), and (110) surfaces of Al, Cu, Ru, Rh, Pd, Ag, Pt, and Au. We interpret the surface energy from liquid metal measurements as the mean of the solid-state surface energies over these three lowest-index crystal faces. We compare experimental (and random phase approximation) reference values to those of a family of nonempirical semilocal density functionals, from the basic local density approximation (LDA) to our most advanced general purpose meta-generalized gradient approximation, strongly constrained and appropriately normed (SCAN)...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29040579/cultural-determinants-influence-assisted-reproduction-usage-in-europe-more-than-economic-and-demographic-factors
#13
Patrick Präg, Melinda C Mills
STUDY QUESTION: To what extent do financial, demographic and cultural determinants explain the vast cross-national differences in ART treatments in Europe? SUMMARY ANSWER: The normative cultural acceptance of ART is a major driver of ART treatments in Europe, above and beyond differences in country wealth, demographic aspects and religious composition. WHAT IS KNOWN ALREADY: There are vast differences in the number of ART treatments across European countries, which are to some extent related to country affluence, regulation, and insurance coverage and costs...
September 29, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29039367/availability-of-computerised-medical-record-system-data-to-compare-models-of-child-health-care-in-primary-care-across-europe
#14
Harshana Liyanage, Uy Hoang, Filipa Ferreira, Denise Alexander, Michael Rigby, Mitch Blair, Simon De Lusignan
Computerised medical record (CMR) system data can be used to compare different models of health care for children. We identified sources of data from the Models of Child Health Appraised (MOCHA) project that compares family doctor led with paediatrician led and mixed models of child care using index conditions. Asthma and immunisation coverage are the first of these. We explored the extent to which an established Patient Registries Initiative (PARENT); MOCHA's own survey (MIROI); the European Centre for Disease Control (ECDC) immunisation information system survey and the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) registry of data sources provided data to make comparisons of child health care...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29038686/the-assessment-of-psychopathology-among-traumatized-refugees-measurement-invariance-of-the-harvard-trauma-questionnaire-and-the-hopkins-symptom-checklist-25-across-five-linguistic-groups
#15
Tim R Wind, Niels van der Aa, Simone de la Rie, Jeroen Knipscheer
Background: Questionnaires are widely used to assess the mental health status of refugees, whereas their construct validity largely remains unexplored. Objective: This study examined the construct validity of two widely-used instruments for the assessment of PTSD symptoms (Harvard Trauma Questionnaire [HTQ]; 16 items) and symptoms of anxiety and depression (Hopkins Symptom Check list-25 [HSCL-25]; 25 items) among Dutch and refugee patients with different linguistic backgrounds. Method: We applied exploratory factor analyses and measurement invariance analyses to test construct validity...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29038071/contraceptive-method-use-in-the-united-states-trends-and-characteristics-between-2008-2012-and-2014
#16
Megan L Kavanaugh, Jenna Jerman
OBJECTIVE: To examine levels of, correlates of, and changes in the use of individual and grouped methods of contraception among U.S. females aged 15-44 from 2008 to 2014. STUDY DESIGN: Using three rounds of the National Survey of Family Growth, we analyzed samples of 12,279 (2008), 5,601 (2012), and 5,699 (2014) females. We conducted simple and multivariable logistic regression analyses to identify associations between demographic characteristics and contraceptive use, as well as between characteristics and changes in use patterns...
October 13, 2017: Contraception
https://www.readbyqxmd.com/read/29035299/two-distinct-conformations-in-bet-v-2-determine-its-proteolytic-resistance-to-cathepsin-s
#17
Wai Tuck Soh, Peter Briza, Elfriede Dall, Claudia Asam, Mario Schubert, Sara Huber, Lorenz Aglas, Barbara Bohle, Fatima Ferreira, Hans Brandstetter
Birch pollen allergy affects more than 20% of the European allergic population. On a molecular level, birch pollen allergy can be linked to the two dominant allergens Bet v 1 and Bet v 2. Bet v 2 belongs to the profilin family, which is abundant in the plant kingdom. Importantly, the homologous plant profilins have a conserved cysteine motif with a currently unknown functional relevance. In particular, it is unknown whether the motif is relevant for disulfide formation and to what extent it would affect the profilins' structural, functional and immunological properties...
October 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29034322/socioeconomic-segregation-of-activity-spaces-in-urban-neighborhoods-does-shared-residence-mean-shared-routines
#18
Christopher R Browning, Catherine A Calder, Lauren J Krivo, Anna L Smith, Bethany Boettner
Residential segregation by income and education is increasing alongside slowly declining black-white segregation. Segregation in urban neighborhood residents' non-home activity spaces has not been explored. How integrated are the daily routines of people who live in the same neighborhood? Are people with different socioeconomic backgrounds that live near one another less likely to share routine activity locations than those of similar education or income? Do these patterns vary across the socioeconomic continuum or by neighborhood structure? The analyses draw on unique data from the Los Angeles Family and Neighborhood Survey that identify the location where residents engage in routine activities...
February 2017: Russell Sage Foundation Journal of the Social Sciences: RSF
https://www.readbyqxmd.com/read/29033684/fluorine-18-2-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-masquerading-as-a-case-of-sporadic-malignant-peripheral-nerve-sheath-tumor-of-lower-extremity-presenting-as-massive-lower-limb-edema
#19
Deepa Singh, Rajender Kumar, Ashim Das, Subhash C Varma, Bhagwant R Mittal
Malignant peripheral nerve sheath tumors (MPNSTs) are rare neuroectodermal tumors resulting from the malignant transformation of benign plexiform neurofibromas. The sporadic form of these tumors is rare than familial variants (seen in neurofibromatosis Type 1) and making the diagnosis difficult. We are presenting a case of 40--year-old female with the complaint of progressive swelling of lower limb with initial suspicion of lymphedema and underwent lymphoscintigraphy, magnetic resonance imaging, and finally fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scans were done to rule out mitotic etiology and extent of the disease...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29031855/furin-deficiency-in-myeloid-cellsleads-to-attenuated-revascularization-in-a-mouse-model-of-oxygen-induced-retinopathy
#20
Maria Vähätupa, Zuzet Martinez Cordova, Saara Aittomäki, Hannu Uusitalo, Tero A H Järvinen, Marko Pesu, Hannele Uusitalo-Järvinen
Diabetic retinopathy is a vision-threatening disease associated chronic retinal inflammation and hypoxia leading to abnormal angiogenesis. Furin, a member of the proprotein convertase family of proteins, has been implicated in the regulation of angiogenesis due to its essential role in the activation of several angiogenic growth factors, including vascular endothelial growth factor-C (VEGF-C), VEGF-D and transforming growth factor - β (TGF- β). In the present study, we evaluated expression of furin in the retina and its role in retinal angiogenesis...
October 12, 2017: Experimental Eye Research
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