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https://www.readbyqxmd.com/read/29667166/disability-differentials-in-educational-attainment-in-england-primary-and-secondary-effects
#1
Stella Chatzitheochari, Lucinda Platt
Childhood disability has been largely overlooked in social stratification and life course research. As a result, we know remarkably little about mechanisms behind well-documented disability differentials in educational outcomes. This study investigates educational transitions of disabled youth using data from the Longitudinal Study of Young People in England. We draw on social stratification literature on primary and secondary effects as well as that on stigma and labelling in order to explain disabled young people's educational outcomes...
April 17, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29666321/glutathione-s-transferase-m1-and-t1-null-genotype-frequency-distribution-among-four-tribal-populations-of-western-india
#2
Prem Chandra Suthar, Pulakes Purkait, Kiran Uttaravalli, B N Sarkar, Rakshit Ameta, Mithun Sikdar
Glutathione S transferase (GST) family is a key contributor in the detoxification mechanism of our body.Deletion of the genes within this family has been reported in the failure of detoxification system, to some extent leading to various types of cancers and other life threatening diseases. The existing data and reports on the association of null genotype of both GSTM1 and GSTT1 genes for various diseases are inconsistent. But knowledge of the polymorphic distributions of genotypes in different populations is important for investigating the risk factors in different epidemiological studies...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666126/domains-of-health-related-quality-of-life-in-age-related-macular-degeneration-a-qualitative-study-in-the-chinese-cultural-context
#3
Wei Bian, Junli Wan, Graeme Smith, Shiying Li, Mingqiong Tan, Fengjiao Zhou
OBJECTIVE: To explore which areas of health-related quality of life were affected in Chinese patients, and to identify whether the areas are well covered by validated questionnaires. DESIGN: A qualitative study based on semistructured interviews was conducted. A qualitative thematic analysis following the approach of Colaizzi was used to analyse the interview data for significant statements and phrases. The themes and subthemes organised from the analysis were then compared by using the following current instruments: National Eye Institute Visual Function Questionnaire (NEI-VFQ-25), Macular Disease Quality of life Questionnaire (MacDQoL) and Low-Luminance Questionnaire (LLD)...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665849/an-innovative-immunotherapeutic-strategy-for-ovarian-cancer-clec10a-and-glycomimetic-peptides
#4
Laura L Eggink, Katherine F Roby, Robert Cote, J Kenneth Hoober
BACKGROUND: Receptors specific for the sugar N-acetylgalactosamine (GalNAc) include the human type II, C-type lectin receptor macrophage galactose-type lectin/C-type lectin receptor family member 10A (MGL/CLEC10A/CD301) that is expressed prominently by human peripheral immature dendritic cells, dendritic cells in the skin, alternatively-activated (M2a) macrophages, and to lesser extents by several other types of tissues. CLEC10A is an endocytic receptor on antigen-presenting cells and has been proposed to play an important role in maturation of dendritic cells and initiation of an immune response...
April 17, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29662487/acquisition-of-n-glycosylation-sites-in-immunoglobulin-heavy-chain-genes-during-local-expansion-in-parotid-salivary-glands-of-primary-sj%C3%A3-gren-patients
#5
Annie Visser, Marieke E Doorenspleet, Niek de Vries, Fred K L Spijkervet, Arjan Vissink, Richard J Bende, Hendrika Bootsma, Frans G M Kroese, Nicolaas A Bos
Previous studies revealed high incidence of acquired N-glycosylation sites acquired N-glycosylation sites in RNA transcripts encoding immunoglobulin heavy variable region (IGHV) 3 genes from parotid glands of primary Sjögren's syndrome (pSS) patients. In this study, next generation sequencing was used to study the extent of ac-Nglycs among clonally expanded cells from all IGVH families in the salivary glands of pSS patients. RNA was isolated from parotid gland biopsies of five pSS patients and five non-pSS sicca controls...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29659621/referral-bias-in-als-epidemiological-studies
#6
Giancarlo Logroscino, Benoit Marin, Marco Piccininni, Simona Arcuti, Adriano Chiò, Orla Hardiman, James Rooney, Stefano Zoccolella, Philippe Couratier, Pierre-Marie Preux, Ettore Beghi
BACKGROUND: Despite concerns about the representativeness of patients from ALS tertiary centers as compared to the ALS general population, the extent of referral bias in clinical studies remains largely unknown. Using data from EURALS consortium we aimed to assess nature, extent and impact of referral bias. METHODS: Four European ALS population-based registries located in Ireland, Piedmont, Puglia, Italy, and Limousin, France, covering 50 million person-years, participated...
2018: PloS One
https://www.readbyqxmd.com/read/29656017/proteomic-and-toxinological-characterization-of-the-venom-of-the-south-african-ringhals-cobra-hemachatus-haemachatus
#7
Andrés Sánchez, María Herrera, Mauren Villalta, Daniela Solano, Álvaro Segura, Bruno Lomonte, José María Gutiérrez, Guillermo León, Mariángela Vargas
The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom is composed of abundant three-finger toxins (3FTxs; 63.3%), followed by phospholipases A2 (PLA2 s; 22.8%), snake venom metalloproteinases (SVMPs 7.1%), cysteine-rich secretory proteins (CRISPs; 4.1%) and Kunitz type protease inhibitors (KTPIs; 1.5%). 3FTxs are the main responsible for lethality and myotoxicity in mice and in vitro anticoagulant activity...
April 12, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29652992/-phenotypic-and-mutational-analysis-of-a-pedigree-affected-with-hereditary-coagulation-factor-%C3%A2-deficiency
#8
Mengcha Tian, Hong Xia, Zhishan Zhang, Yanhui Jin, Kankan Su, Mingshan Wang
OBJECTIVE: To explore the molecular pathogenesis for a pedigree affected with coagulation factor Ⅴ (FⅤ) deficiency. METHODS: Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), coagulation factor Ⅱ activity (FⅡ: C), FⅤ activity (FⅤ: C), coagulation factor Ⅶ activity (FⅦ: C), and coagulation factor Ⅹ activity (FⅩ: C) were determined with a STAGO automatic coagulometer. FⅤ antigen (FⅤ: Ag) was detected with enzyme linked immunosorbent assay (ELISA)...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29651645/parental-depressive-symptoms-as-a-risk-factor-for-child-depressive-symptoms-testing-the-social-mediators-in-internationally-adopted-children
#9
Krista Liskola, Hanna Raaska, Helena Lapinleimu, Marko Elovainio
Parental depressive symptoms have shown to be associated with offspring depression but much of the research has been focused on maternal depression. The aim of our study was to investigate the extent to which depressive symptoms of both parents associate with offspring depressive symptoms and whether social factors mediate these associations using data from adopted children with no shared genetic background. Data were derived from the Finnish Adoption survey study (a subsample of adopted children aged between 9 and 12 years, n = 548)...
April 12, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29629506/what-influences-parental-engagement-in-early-intervention-parent-program-and-community-predictors-of-enrolment-retention-and-involvement
#10
Naomi J Hackworth, Jan Matthews, Elizabeth M Westrupp, Cattram Nguyen, Tracey Phan, Amanda Scicluna, Warren Cann, Donna Bethelsen, Shannon K Bennetts, Jan M Nicholson
Poor participant engagement undermines individual and public health benefits of early intervention programs. This study assessed the extent to which three types of engagement (participant enrolment, retention and involvement) were influenced by individual, program and contextual factors. Data were from a cluster randomised controlled trial (N = 1447) of a community-based parenting program, delivered at two levels of intensity (group sessions with and without individualised home coaching) conducted in Victoria, Australia...
April 9, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29628723/prevalence-of-postmenopausal-symptoms-its-effect-on-quality-of-life-and-coping-in-rural-couple
#11
Radha Shukla, Jaishree Ganjiwale, Rakhee Patel
Aim: Menopause is a physiological process, with potential to lead to various pathological/psychological complications, leading to change in quality of life (QOL). Although literature suggests the effect of menopause on various aspects of life, there is scarcity of studies from rural setup in this regard. Thus, it is essential to assess extent of menopause-related changes, its awareness, and coping mechanisms in rural couple. This study aimed to find the prevalence of postmenopausal symptoms, its severity, and effect on QOL of rural women and the couples' coping mechanisms...
January 2018: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29626647/multiple-pathways-for-mitophagy-a-neurodegenerative-conundrum-for-parkinson-s-disease
#12
REVIEW
Charleen T Chu
It has been nearly a decade since the first landmark studies implicating familial recessive Parkinson's disease genes in the regulation of selective mitochondrial autophagy. The PTEN-induced kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin (encoded by the PARK2 gene) act together to mark depolarized mitochondria for degradation. There is now an extensive body of literature detailing key mediators and steps in this pathway, based mostly on work in transformed cell lines. However, the degree to which PINK1-triggered mitophagy contributes to mitochondrial quality control in the mammalian brain, and the extent to which its disruption contributes to Parkinson's disease pathogenesis remain uncertain...
April 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29626537/intrinsically-disordered-proteins-link-alternative-splicing-and-post-translational-modifications-to-complex-cell-signaling-and-regulation
#13
Jianhong Zhou, Suwen Zhao, A Keith Dunker
Intrinsically disordered proteins and regions (IDPs and IDRs) lack well-defined tertiary structures, yet carry out various important cellular functions, especially those associated with cell signaling and regulation. In eukaryotes, IDPs and IDRs contain the preferred loci for both alternative splicing (AS) and many post-translational modifications (PTMs). Furthermore, AS and/or PTMs at these loci generally alter the signaling outcomes associated with these IDPs or IDRs, where the functional cooperation of these three features is named the IDP-AS-PTM toolkit...
April 4, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29625547/endonuclease-activity-of-mutl-protein-of-the-rhodobacter-sphaeroides-mismatch-repair-system
#14
M V Monakhova, A I Penkina, A V Pavlova, A M Lyaschuk, V V Kucherenko, A V Alexeevski, V G Lunin, P Friedhoff, G Klug, T S Oretskaya, E A Kubareva
We have purified the MutL protein from Rhodobacter sphaeroides mismatch repair system (rsMutL) for the first time. rsMutL demonstrated endonuclease activity in vitro, as predicted by bioinformatics analysis. Based on the alignment of 1483 sequences of bacterial MutL homologs with presumed endonuclease activity, conserved functional motifs and amino acid residues in the rsMutL sequence were identified: five motifs comprising the catalytic site responsible for DNA cleavage were found in the C-terminal domain; seven conserved motifs involved in ATP binding and hydrolysis and specific to the GHKL family of ATPases were found in the N-terminal domain...
March 2018: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/29625369/maternal-mental-health-during-the-neonatal-period-relationships-to-the-occupation-of-parenting
#15
Rachel Harris, Deanna Gibbs, Kathryn Mangin-Heimos, Roberta Pineda
PURPOSE: To (1) examine the extent of a range of early mental health challenges in mothers with a very preterm infant hospitalized in the NICU and mothers of full-term infants, (2) identify family social background and infant medical factors associated with higher levels of maternal psychological distress, and (3) assess the relationship between maternal psychological distress and maternal perceptions of the parenting role, parenting confidence and NICU engagement. METHODS: At hospital discharge 37 mothers of very preterm infants (≤32 weeks gestation) and 47 mothers of full-term infants (≥37 weeks gestation) completed structured assessments of their psychological wellbeing and transition to parenting...
April 3, 2018: Early Human Development
https://www.readbyqxmd.com/read/29622922/specialists-and-generalists-coexist-within-a-population-of-spider-hunting-mud-dauber-wasps
#16
Erin C Powell, Lisa A Taylor
Individual foraging specialization describes the phenomenon where conspecifics within a population of generalists exhibit differences in foraging behavior, each specializing on different prey types. Individual specialization is widespread in animals, yet is understudied in invertebrates, despite potential impacts to food web and population dynamics . Sceliphron caementarium (Hymenoptera: Sphecidae) is an excellent system to examine individual specialization. Females of these mud dauber wasps capture and paralyze spiders which they store in mud nests to provision their offspring...
May 2017: Behavioral Ecology: Official Journal of the International Society for Behavioral Ecology
https://www.readbyqxmd.com/read/29622057/a-longitudinal-study-on-psychosocial-causes-and-consequences-of-internet-gaming-disorder-in-adolescence
#17
Lutz Wartberg, Levente Kriston, Matthias Zieglmeier, Tania Lincoln, Rudolf Kammerl
BACKGROUND: In 2013, Internet gaming disorder (IGD) was incorporated in the current version of the DSM-5. IGD refers to a problematic use of video games. Longitudinal studies on the etiology of IGD are lacking. Furthermore, it is currently unclear to which extent associated psychopathological problems are causes or consequences of IGD. In the present survey, longitudinal associations between IGD and adolescent and parental mental health were investigated for the first time, as well as the temporal stability of IGD...
April 6, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29621315/molecular-evolution-of-dnmt1-in-vertebrates-duplications-in-marsupials-followed-by-positive-selection
#18
David Alvarez-Ponce, María Torres-Sánchez, Felix Feyertag, Asmita Kulkarni, Taylen Nappi
DNA methylation is mediated by a conserved family of DNA methyltransferases (Dnmts). The human genome encodes three active Dnmts (Dnmt1, Dnmt3a and Dnmt3b), the tRNA methyltransferase Dnmt2, and the regulatory protein Dnmt3L. Despite their high degree of conservation among different species, genes encoding Dnmts have been duplicated and/or lost in multiple lineages throughout evolution, indicating that the DNA methylation machinery has some potential to undergo evolutionary change. However, little is known about the extent to which this machinery, or the methylome, varies among vertebrates...
2018: PloS One
https://www.readbyqxmd.com/read/29621290/early-life-conditions-and-health-at-older-ages-the-mediating-role-of-educational-attainment-family-and-employment-trajectories
#19
Bruno Arpino, Jordi Gumà, Albert Julià
OBJECTIVES: We examine to what extent the effect of early-life conditions (health and socioeconomic status) on health in later life is mediated by educational attainment and life-course trajectories (fertility, partnership, employment). METHODS: Using data from the Survey of Health, Ageing and Retirement in Europe (N = 12,034), we apply, separately by gender, multichannel sequence analysis and cluster analysis to obtain groups of similar family and employment histories...
2018: PloS One
https://www.readbyqxmd.com/read/29620721/pediatric-coccidioidomycosis-case-series-from-a-california-pediatric-infectious-diseases-clinic
#20
Lauren A Lee, Gail L Sondermeyer Cooksey, Janice J Kim, Amandeep Kahal, Debra Gilliss, Fouzia Naeem, James M McCarty, Duc J Vugia
BACKGROUND: Coccidioidomycosis is not as well described in the pediatric population as it is in the adult population. We describe clinical findings, diagnosis, and management of coccidioidomycosis in 108 pediatric patients seen in an outpatient clinic in the California Central Valley, an area endemic for coccidioidomycosis. METHODS: We reviewed medical records of a convenience sample of pediatric patients (≤17 years of age) diagnosed with coccidioidomycosis who visited an infectious diseases clinic in Madera, CA during January 1-October 1, 2012...
April 9, 2018: Pediatric Infectious Disease Journal
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