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https://www.readbyqxmd.com/read/29031127/patients-perceptions-and-experiences-of-living-with-a-surgical-wound-healing-by-secondary-intention-a-qualitative-study
#1
Dorothy McCaughan, Laura Sheard, Nicky Cullum, Jo Dumville, Ian Chetter
BACKGROUND: Most surgical wounds heal by primary intention, that is to say, the edges of the wound are brought together with sutures, staples, adhesive glue or clips. However, some wounds may be left open to heal (if there is a risk of infection, or if there has been significant tissue loss), and are known as 'surgical wounds healing by secondary intention'. They are estimated to comprise approximately 28% of all surgical wounds and are frequently complex to manage. However, they are under researched and little is known of their impact on patients' lives...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29029362/altered-tdp-43-dependent-splicing-in-hspb8-related-distal-hereditary-motor-neuropathy-and-myofibrillar-myopathy
#2
Andrea Cortese, Matilde Laurà, Carlo Casali, Ichizo Nishino, Yukiko K Hayashi, Stefania Magri, Franco Taroni, Cristiana Stuani, Paola Saveri, Maurizio Moggio, Michela Ripolone, A Prelle, C Pisciotta, A Sagnelli, Anna Pichiecchio, Mary M Reilly, Emanuele Buratti, Davide Pareyson
INTRODUCTION: Mutations in the small heat shock protein 22 gene (HSPB8) have been associated with Charcot-Marie-Tooth type 2L, distal hereditary motor neuropathy (dHMN) type IIa and, more recently, distal myopathy/myofibrillar myopathy (MFM) with protein aggregates and TDP-43 inclusions. OBJECTIVE: To report a novel family with HSPB8 (K141E) -related dHMN/MFM and to investigate, in a patient muscle biopsy, whether the presence of protein aggregates was paralleled by altered TDP-43 function...
October 13, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29028811/elevated-expression-of-hsp10-protein-inhibits-apoptosis-and-associates-with-poor-prognosis-of-astrocytoma
#3
Weibing Fan, Shuang-Shi Fan, Juan Feng, Desheng Xiao, Songqing Fan, Jiadi Luo
Astrocytoma is the most common type of primary malignant brain tumor, with pretty lowly 5-year survival rate in patients. Although extended surgical removal of the tumor and postoperative chemotherapy/radiotherapy executed, still there is large recurrence rate, mainly because diffuse glioma tumor cells ubiquitously infiltrate into normal parenchyma. So it becomes a priority to hunt novel molecular and signaling pathway targets to suppress astrocyma progression. HSP10, an important member of Heat shock proteins (Hsps) family, classically works as molecular chaperone folding or degradating of target proteins...
2017: PloS One
https://www.readbyqxmd.com/read/29028792/is-a-psychotherapeutic-approach-possible-in-primary-health-care
#4
Julio Torales, Iván Barrios, Susana Calero
The development of valid psychotherapeutic approaches, adapted to the characteristics of the consultation in primary care, is a subject in constant development. In order to work effectively in a model of psychotherapy adjusted to primary care, the health practitioner (psychiatrist, psychologist, or family physician) must constantly focus on finding the most efficient way to treat the patient, in a short period of time, and with different nuances from those usually used in secondary care: That is, an eclectic and pragmatic approach to dealing with the problems that patients bring to consultation, and a practical and direct way of assisting them, in order to achieve therapeutic goals...
October 11, 2017: Medwave
https://www.readbyqxmd.com/read/29027612/penetrance-of-a-rare-familial-mutation-predisposing-to-papillary-thyroid-cancer
#5
Donika Saporito, Pamela Brock, Heather Hampel, Jennifer Sipos, Soledad Fernandez, Sandya Liyanarachchi, Albert de la Chapelle, Rebecca Nagy
Familial non-medullary thyroid cancer (FNMTC) is clinically defined as two or more first-degree relatives with NMTC and appears to follow an autosomal dominant inheritance pattern. Approximately 5-7% of NMTC is hereditary and affects multiple generations with a young age of onset. The primary aim of this study was to determine the age-specific penetrance of NMTC in individuals from a large family with FNMTC with a previously identified private mutation at 4q32, with a secondary aim to determine the penetrance for benign thyroid disease in this family...
October 12, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29027106/fas-and-mitochondria-mediated-signaling-pathway-involved-in-osteoblast-apoptosis-induced-by-alcl3
#6
Feibo Xu, Limin Ren, Miao Song, Bing Shao, Yanfei Han, Zheng Cao, Yanfei Li
Aluminum (Al) is known to induce apoptosis of osteoblasts (OBs). However, the mechanism is not yet established. To investigate the apoptotic mechanism of OBs induced by aluminum trichloride (AlCl3), the primary OBs from the craniums of fetal Wistar rats were exposed to 0 mg/mL (control group, CG), 0.06 mg/mL (low-dose group, LG), 0.12 mg/mL (mid-dose group, MG), and 0.24 mg/mL (high-dose group, HG) AlCl3 for 24 h, respectively. We observed that AlCl3 induced OB apoptosis with the appearance of apoptotic morphology and increase of apoptosis rate...
October 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29026561/primary-hypogonadism-partial-alopecia-and-m%C3%A3-llerian-hypoplasia-report-of-a-fifth-family-and-review
#7
Ruqayah G Y Al-Obaidi, Bassam M S Al-Musawi
Primary hypogonadism combined with Müllerian hypoplasia and partial alopecia are common features of this syndrome, which was reported only in four earlier families from areas where consanguineous marriage is prevalent. An autosomal recessive pattern of inheritance was suggested earlier and is supported by this report.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29025894/nascent-rna-sequencing-reveals-a-dynamic-global-transcriptional-response-at-genes-and-enhancers-to-the-natural-medicinal-compound-celastrol
#8
Noah Dukler, Gregory T Booth, Yi-Fei Huang, Nathaniel Tippens, Colin T Waters, Charles G Danko, John T Lis, Adam Siepel
Most studies of responses to transcriptional stimuli measure changes in cellular mRNA concentrations. By sequencing nascent RNA instead, it is possible to detect changes in transcription in minutes rather than hours and thereby distinguish primary from secondary responses to regulatory signals. Here, we describe the use of PRO-seq to characterize the immediate transcriptional response in human cells to celastrol, a compound derived from traditional Chinese medicine that has potent anti-inflammatory, tumor-inhibitory, and obesity-controlling effects...
October 12, 2017: Genome Research
https://www.readbyqxmd.com/read/29025695/exploring-the-potential-of-a-wearable-camera-to-examine-the-early-obesogenic-home-environment-comparison-of-sensecam-images-to-the-home-environment-interview
#9
Stephanie Schrempft, Cornelia Hm van Jaarsveld, Abigail Fisher
BACKGROUND: The obesogenic home environment is usually examined via self-report, and objective measures are required. OBJECTIVE: This study explored whether the wearable camera SenseCam can be used to examine the early obesogenic home environment and whether it is useful for validation of self-report measures. METHODS: A total of 15 primary caregivers of young children (mean age of child 4 years) completed the Home Environment Interview (HEI)...
October 12, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29025093/discharge-communication-practices-and-healthcare-provider-and-patient-preferences-satisfaction-and-comprehension-a-systematic-review
#10
Harvey Newnham, Anna Barker, Edward Ritchie, Karen Hitchcock, Harry Gibbs, Sara Holton
Purpose: To systematically review the available evidence about hospital discharge communication practices and identify which practices were preferred by patients and healthcare providers, improved patient and provider satisfaction, and increased patients' understanding of their medical condition. Data sources: OVID Medline, Web of Science, ProQuest, PubMed and CINAHL plus. Study selection: Databases were searched for peer-reviewed, English-language papers, published to August 2016, of empirical research using quantitative or qualitative methods...
September 7, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29025070/interdisciplinary-family-conferences-to-improve-patient-experience-in-the-neonatal-intensive-care-unit
#11
Jennifer A Trujillo, Yesenia Fernandez, Lyla Ghafoori, Kristina Lok, Arwin Valencia
Parents play a significant role in the development of their neonate. They can affect the length of stay in a neonatal intensive care unit (NICU) and are seen as an integral part of the team. Parents are often put in positions where difficult decision making is required of them in the care of their critically ill child. Studies suggest that one way to improve the family's experience and to encourage their involvement is by establishing a formal and focused family conference. Therefore, the NICU social workers and the interdisciplinary team collaborated to formulate strategies to improve communication that would enhance current practice...
September 15, 2017: Health & Social Work
https://www.readbyqxmd.com/read/29025038/selective-progesterone-receptor-modulators-for-fertility-preservation-in-women-with-symptomatic-uterine-fibroids
#12
Mohamed Ali, Ayman Al-Hendy
Uterine Fibroids (UF, AKA: leiomyoma) are the most important benign neoplastic threat to women's health, with costs up to hundreds of billions of health care dollars worldwide. UF caused-morbidities exert a tremendous health toll, impacting the quality of life of women of all ethnicities, especially women of color. Clinical presentations include heavy vaginal bleeding, pelvic pain, bulk symptoms, subfertility, and obstetric complications. Current management strategies heavily lean towards surgical procedures, nonetheless the choice of treatment is generally subject to patient's age and her desire to preserve future fertility...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024880/experience-with-and-amount-of-postpartum-maternity-care-comparing-women-who-rated-the-care-they-received-from-the-maternity-care-assistant-as-good-or-less-than-good-care
#13
C I Baas, T A Wiegers, T P de Cock, J J H M Erwich, E R Spelten, E K Hutton
OBJECTIVE: The postpartum period is an important time in the lives of new mothers, their children and their families. The aim of postpartum care is 'to detect health problems of mother and/or baby at an early stage, to encourage breastfeeding and to give families a good start' (Wiegers, 2006). The Netherlands maternity care system aims to enable every new family to receive postpartum care in their home by a maternity care assistant (MCA). In order to better understand this approach, in this study we focus on women who experienced the postpartum care by the MCA as 'less than good' care...
September 19, 2017: Midwifery
https://www.readbyqxmd.com/read/29024829/distal-renal-tubular-acidosis-in-a-libyan-patient-evidence-for-digenic-inheritance
#14
Majdi Nagara, Gregori Papagregoriou, Rim Ben Abdallah, Zied Landoulsi, Yosra Bouyacoub, Sahar Elouej, Rym Kefi, Tommaso Pippucci, Voskarides Konstantinos, Anu Bashamboo, Kenneth McElreavey, Mongia Hachicha, Giovanni Romeo, Marco Seri, Constantinos Deltas, Sonia Abdelhak
AIM OF THE STUDY: Recent advances in understanding the underlying molecular mechanism for distal renal tubular acidosis (dRTA), led to an increased attention towards the primary and the familial forms of the disease. Mutations in ATP6V1B1 and ATP6V0A4 are usually responsible for the recessive form of the disease. Mutations in gene AE1 encoding the Cl-/HCO3- exchanger, usually present as dominant dRTA, but a recessive pattern has been recently described. Our objective is to identify the mutational spectrum responsible of dRTA in a consanguineous Libyan family...
October 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29024808/critical-care-nurses-experiences-of-withdrawal-of-treatment-a-systematic-review-of-qualitative-evidence
#15
REVIEW
Brandi Vanderspank-Wright, Nikolaos Efstathiou, Amanda D Vandyk
BACKGROUND: Death and dying is a reality of the clinical context of the intensive care unit. Death often follows a decision to withdraw life-sustaining treatments. Critical care nurses, are the primary care providers to patients and families at the end-of-life in the intensive care unit. OBJECTIVE: To synthesize qualitative evidence on the experiences of critical care nurses who have cared for patients and families throughout the process of withdrawal of life-sustaining treatment...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29023923/treatment-abandonment-in-children-with-cancer-in-sub-saharan-africa-systematic-literature-review-and-meta-analysis
#16
REVIEW
Rikka Mansell
AIMS: To establish and quantify the main reasons for treatment abandonment in children with cancer in Sub-Saharan Africa through a systematic review of the literature. BACKGROUND: Great advances have been made in the treatment of childhood cancer, however this requires that families are able to complete treatment. Failure to do this is referred to as treatment abandonment, which is recognised as a reason for treatment failure. DESIGN: Systematic review and meta-analysis of data on the reasons for treatment abandonment in Sub-Saharan Africa...
October 11, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29023666/nutritional-intervention-and-neurodevelopmental-outcome-in-infants-with-suspected-cerebral-palsy-the-dolphin-infant-double-blind-randomized-controlled-trial
#17
Morag J Andrew, Jeremy R Parr, Christine Montague-Johnson, Karen Laler, Cathy Qi, Bonny Baker, Peter B Sullivan
AIM: To investigate whether docosahexaenoic acid (DHA), choline, and uridine-5-monophosphate (UMP) supplementation improves neurodevelopmental outcome in infants with suspected cerebral palsy (CP) versus a comparison group of children. METHOD: Infants aged 1 to 18 months with suspected CP were recruited from UK child development centres. Participants received daily treatment or control supplementation for 2 years (double-blind randomized control design). Stratification was by age, sex, predominant pattern of motor involvement (four limbs or other), and visual impairment (or not)...
October 12, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29023082/be-vigilant-for-skin-manifestations-of-inherited-cancer-syndromes
#18
Alice SM Tidman
More than 200 hereditary cancer susceptibility syndromes have been described, and it is thought that they account for 5-10% of all cancers. Many have dermatological manifestations (usually lesions, occasionally rashes) which frequently precede other systemic pathology. Dermatological signs are usually non-specific and often trivial in appearance, making their significance easy to overlook and a clinical diagnosis challenging. Histological examination is often required to differentiate lesions. They are usually benign and pathologically unrelated to the primary tumours, with the exception of the atypical moles of the dysplastic naevus syndrome, and may present simply as a cosmetic problem for the patient...
January 2017: Practitioner
https://www.readbyqxmd.com/read/29022766/a-solution-focused-approach-to-understanding-patient-motivation-in-diabetes-self-management-gender-differences-and-implications-for-primary-care
#19
Tajudaullah Bhaloo, Michael Juma, Christine Criscuolo-Higgins
Objective Healthcare providers often neglect to recognize the role they play in motivating patients with diabetes to perform self-management. Our aims were to understand what motivates patients with diabetes to implement recommended self-management practices and understand the role of the primary care team in patient motivation. Methods We use a solution-focused qualitative approach, supplemented with a quantitative scale. We used a purposive sampling strategy to invite patients with uncontrolled diabetes. Semi-structured telephone interviews were conducted and analyzed using content and thematic analysis...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/29022406/our-experience-with-syrian-refugee-patients-at-the-child-and-adolescent-psychiatry-clinic-in-gaziantep-turkey
#20
Mehmet Karadag, Cem Gokcen, Funda Dandil, Baran Calisgan
Reporting from Turkey's frontier with the civil war in Syria, we examined the demographic characteristics, psychiatric diagnoses and treatments for the Syrian refugee patients who have presented to Gaziantep University, Child and Adolescent Psychiatry Clinic through 2016 and the first half of 2017 retrospectively, having aimed to understand the special characteristics and needs of this novel patient group. Within a year and a half, we evaluated 51 children and adolescents and 25 (51%) had come from refugee camps, where primary healthcare services are available...
October 12, 2017: International Journal of Psychiatry in Clinical Practice
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