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https://www.readbyqxmd.com/read/29220860/patients-willingness-to-defer-resection-of-diminutive-polyps-results-of-a-multicenter-survey
#1
Daniel von Renteln, Mickael Bouin, Alan N Barkun, Audrey Weber, Douglas J Robertson, Joseph C Anderson, Heiko Pohl
Background and study aims Current colonoscopy practice requires removal of diminutive polyps. This is associated with costs, but the benefits to colorectal cancer (CRC) prevention remain unclear. The study aim was to understand patients' willingness to defer resection of diminutive polyps and to examine the factors that influence patients' decisions. Patients and methods Adults presenting for a colonoscopy were surveyed at three hospitals in the USA and Canada. Survey domains included: patient characteristics, risk perception, knowledge about CRC risk, willingness to defer polyp resection, and associated concerns...
December 8, 2017: Endoscopy
https://www.readbyqxmd.com/read/29220598/hope-for-the-future-but-fear-the-risk-of-stigma-ethiopian-family-caregivers-lived-experience-of-caring-for-their-hiv-positive-child-two-years-after-starting-antiretroviral-treatment
#2
Mulatu Biru, Pia Lunqvist, Mitikie Molla, Degu Jerene, Inger Hallström
Family caregivers are believed to be the primary source of support for HIV-affected children. There is limited evidence about practices of support for caregivers, to strengthen them and to enhance the welfare of HIV positive children, especially in African settings. Our aim was therefore to illuminate caregivers' lived experiences of caring for a child in Ethiopia 2 years after the child was enrolled in antiretroviral therapy. Qualitative interviews with 18 family caregivers of 18 children were performed and analyzed using an inductive design with a hermeneutic phenomenological approach...
December 8, 2017: Comprehensive Child and Adolescent Nursing
https://www.readbyqxmd.com/read/29218622/inhibiting-cdk-in-cancer-therapy-current-evidence-and-future-directions
#3
REVIEW
Smruthi Vijayaraghavan, Stacy Moulder, Khandan Keyomarsi, Rachel M Layman
Cell cycle dysregulation is a hallmark of all cancers, resulting in uncontrolled proliferation. Cyclin dependent kinases (CDKs), a family of proteins that are involved in the regulation of the cell cycle, are frequently overexpressed or mutated in cancer. Hence, CDK-inhibiting drugs have been developed and evaluated as cancer therapeutics. Clinical trials have shown CDK4/6 inhibitors (CDK4/6i) to be relatively safe and effective, and these are now standard of care treatment for advanced hormone receptor positive breast cancer...
December 7, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29218493/direct-biological-effects-of-fractional-ultrapulsed-co2-laser-irradiation-on-keratinocytes-and-fibroblasts-in-human-organotypic-full-thickness-3d-skin-models
#4
L Schmitt, S Huth, P M Amann, Y Marquardt, R Heise, K Fietkau, L Huth, T Steiner, F Hölzle, J M Baron
Molecular effects of various ablative and non-ablative laser treatments on human skin cells-especially primary effects on epidermal keratinocytes and dermal fibroblasts-are not yet fully understood. We present the first study addressing molecular effects of fractional non-sequential ultrapulsed CO2 laser treatment using a 3D skin model that allows standardized investigations of time-dependent molecular changes ex vivo. While histological examination was performed to assess morphological changes, we utilized gene expression profiling using microarray and qRT-PCR analyses to identify molecular effects of laser treatment...
December 7, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29217964/sit-down-and-play-a-preventive-primary-care-based-program-to-enhance-parenting-practices
#5
Reshma Shah, Daniela DeFrino, Yoonsang Kim, Marc Atkins
The primary care office offers an ideal setting to encourage parenting behaviors that promote early childhood development. We conducted a pilot study to establish feasibility and acceptability of Sit Down and Play (SDP), a brief primary care-based program to facilitate positive parenting behaviors through take-home play activities. A prospective 1-month study was conducted in an urban primary care clinic. SDP was administered to 30 caregivers of 6-12 month old children while they waited for their well-child appointment...
February 2017: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/29217955/determinants-of-podoconiosis-a-case-control-study
#6
Berhanu Elfu Feleke
Background: Podoconiosis is a non-filarial swelling of lower extremity endemic in tropical regions, North America and India. The etiology and pathophysiology of the disease remain unknown. The objective of this study was to identify the determinants of Podoconiosis. Methods: Unmatched case control study design was conducted. The sample size was calculated using Epi-info soft ware: 95% CI, 85% power, control to case ratio of 2:1, expected frequency of barefoot among controls 50%, odds ratio of 1...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217947/coexistence-of-peripheral-spondyloarthritis-and-familial-adenomatous-polyposis-a-rare-case-report-with-treatment-contradictions-and-review-of-the-literature
#7
Berna Urkmez, Muge Kepekci, Sevde Ozer Posul, Aylin Rezvani
Background: The coexistence of familial adenomatous polyposis and spondyloarthritis is rarely defined in literature. The primary aim of this presentation is to report a development of peripheral arthritis in 3 years following colon surgery with the diagnosis of familial adenomatous polyposis (FAP). The secondary aim is to discuss the challenge of in treatment of refractory arthritis, which needs to be treated with biologics. However, it is not yet known well about their safety on patients who have risks for cancer development...
July 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217583/structure-of-the-cold-and-menthol-sensing-ion-channel-trpm8
#8
Ying Yin, Mengyu Wu, Lejla Zubcevic, William F Borschel, Gabriel C Lander, Seok-Yong Lee
Transient receptor potential melastatin (TRPM) cation channels are polymodal sensors that are involved in a variety of physiological processes. Within the TRPM family, member 8 (TRPM8) is the primary cold- and menthol-sensor in humans. We determined the cryo-electron microscopy structure of the full-length TRPM8 from the collared flycatcher at an overall resolution of ~4.1 Å. Our TRPM8 structure reveals a three-layered architecture. The amino-terminal domain with a fold distinct among known TRP structures, together with the carboxyl-terminal region, forms a large two-layered cytosolic ring that extensively interacts with the transmembrane channel layer...
December 7, 2017: Science
https://www.readbyqxmd.com/read/29216683/human-perforin-gene-variation-is-geographically-distributed
#9
Robin C Willenbring, Yasuhiro Ikeda, Larry R Pease, Aaron J Johnson
BACKGROUND: Deleterious mutations in PRF1 result in lethal, childhood disease, familial hemophagocytic lymphohistiocytosis type 2 (FHL 2). However, not all mutations in PRF1 are deleterious and result in FHL 2. Currently, these nondeleterious mutations are being investigated in the onset of numerous disorders, such as lymphomas and diabetes. Yet, there is still an overwhelmingly large amount of PRF1 mutations that are not associated with disease. METHODS: We conducted a post hoc analysis of the PRF1 mutations in the coding region using the recently published Exome Aggregation Consortium genomes, Leiden Open Variation Database, NCBI SNP database, and primary literature to better understand PRF1 variation in the human population...
December 7, 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29216625/missing-links-in-epithelial-mesenchymal-transition-long-non-coding-rnas-enter-the-arena
#10
Lei Wang, Fan Yang, Lin-Tao Jia, An-Gang Yang
Cancer metastasis occurs through a series of sequential steps, which involves dissemination of tumor cells from a primary site and colonization in distant tissues. To promote the invasion-metastasis cascade, carcinoma cells usually initiate a cell-biological program called epithelial-mesenchymal transition (EMT), which is orchestrated by a set of master regulators, including TGF-β, Snail, ZEB and Twist families. The biological activities of these molecules are tightly regulated by a variety of cell-intrinsic pathways as well as extracellular cues...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29216304/correction-the-impact-of-the-brazilian-family-health-on-selected-primary-care-sensitive-conditions-a-systematic-review
#11
Mayara Lisboa Bastos, Dick Menzies, Thomas Hone, Kianoush Dehghani, Anete Trajman
[This corrects the article DOI: 10.1371/journal.pone.0182336.].
2017: PloS One
https://www.readbyqxmd.com/read/29215904/practice-procedures-in-models-of-primary-care-collaboration-for-children-with-adhd
#12
Jessica A Moore, Kathryn Karch, Valeriia Sherina, Aubree Guiffre, Sandra Jee, Lynn C Garfunkel
INTRODUCTION: With nationwide movement toward an integrated medical home, evidence to support, compare, and specify effective models for collaboration between primary care and behavioral health professionals is essential. This study compared 2 models of primary care with behavioral health integration on American Academy of Pediatrics guideline adherence for attention-deficit/hyperactivity disorder (ADHD) assessment and treatment. METHOD: We conducted a retrospective chart review of a random sample of children aged 6-13 years, seen for ADHD services in 2 primary care offices, 1 fully integrated model and 1 co-located service only model, comparing ADHD assessment and treatment practices...
December 7, 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29214932/-students-having-parents-with-mental-health-issues-and-teachers-mental-health-literacy
#13
Dirk Bruland, Katharina Kornblum, Stefanie Harsch, Janine Bröder, Orkan Okan, Ullrich Bauer
Students Having Parents with Mental Health Issues and Teachers' Mental Health Literacy Mental health issues of parents of school children often negatively affects the children as well, including their school performance and social behavior in the school setting. Teachers are then required to take actions with regards to supporting children in their coping with and mastering of their home situation and their responds to educational demands. As such, schools' and teachers' actions can either support affected children and fulfill a protective function or respond inappropriately, with negative impact on the affected children...
December 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29214229/feasibility-trial-of-a-psychoeducational-intervention-for-parents-with-personality-difficulties-the-helping-families-programme
#14
Crispin Day, Jackie Briskman, Mike J Crawford, Lucy Harris, Paul McCrone, Mary McMurran, Paul Moran, Lou Morgan, Stephen Scott, Daniel Stahl, Paul Ramchandani, Timothy Weaver
The Helping Families Programme is a psychoeducational parenting intervention that aims to improve outcomes and engagement for parents affected by clinically significant personality difficulties. This is achieved by working collaboratively with parents to explore ways in which their emotional and relational difficulties impact on parenting and child functioning, and to identify meaningful and realistic goals for change. The intervention is delivered via one-to-one sessions at weekly intervals over a period of 16 weeks...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29214049/latent-autoimmune-diabetes-of-adulthood-case-report
#15
Cristen P Page, Brian Fitzgerald, Emily M Hawes
Background: Primary care clinicians will see a higher incidence of type 2 diabetes in adult patients, and the diagnosis and management of an initial presentation of type 1 diabetes can pose challenges to clinicians who see it less frequently. Symptoms of hyperglycemia and risk of ketoacidosis may be missed. Further, endocrine autoimmune disease can run together in patients and families. Case presentation: A 49-year-old Caucasian female with history of pituitary adenoma and Graves' disease with history of thyroid ablation presented in the outpatient setting due to hand tingling of her right middle finger that was worse in the mornings and improved throughout the day...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29214031/parp-inhibitors-as-potential-therapeutic-agents-for-various-cancers-focus-on-niraparib-and-its-first-global-approval-for-maintenance-therapy-of-gynecologic-cancers
#16
REVIEW
Mekonnen Sisay, Dumessa Edessa
Poly (ADP-ribose) polymerases (PARPs) are an important family of nucleoproteins highly implicated in DNA damage repair. Among the PARP families, the most studied are PARP1, PARP2 and PARP 3. PARP1 is found to be the most abundant nuclear enzyme under the PARP series. These enzymes are primarily involved in base excision repair as one of the major single strand break (SSB) repair mechanisms. Being double stranded, DNA engages itself in reparation of a sub-lethal SSB with the aid of PARP. Moreover, by having a sister chromatid, DNA can also repair double strand breaks with either error-free homologous recombination or error-prone non-homologous end-joining...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/29213249/skewed-sociolinguistic-awareness-of-a-native-non-standard-dialect-evidence-from-the-cypriot-greek-writing-of-greek-cypriot-students
#17
Ioli Ayiomamitou, Androula Yiakoumetti
Over the last 50 years, sociolinguistic research in settings in which a regional, social, or ethnic non-standard linguistic variety is used alongside the standard variety of the same language has steadily increased. The educational implications of the concomitant use of such varieties have also received a great deal of research attention. This study deals with regional linguistic variation and its implications for education by focusing on the Greek Cypriot educational context. This context is ideal for investigating the linguistic profiles of speakers of proximal varieties as the majority of Greek Cypriots are primarily educated in just one of their varieties: the standard educational variety...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29213013/annexin-a1-is-a-novel-target-gene-of-gonadotropin-releasing-hormone-in-l%C3%AE-t2-gonadotrope-cells
#18
Numfa Fungbun, Tungmahasuk Doungrut, Ryota Terashima, Shiro Kurusu, Mitsumori Kawaminami
Gonadotropin-releasing hormone (GnRH) regulates gonadotropin secretion. We previously demonstrated that the expression of annexin A5 (ANXA5) is stimulated by GnRH in gonadotropes and has a significant role in gonadotropin secretion. It is therefore of interest to know whether other members of the ANXA family, which consists of twelve structurally related members, are also regulated by GnRH. Therefore, the expression of all annexins was examined in LβT2gonadotrope cells. ANXA4, A5, A6, A7, and A11 were detected in LβT2cells...
December 6, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29212662/sharing-the-load-mex67-mtr2-cofunctions-with-los1-in-primary-trna-nuclear-export
#19
Kunal Chatterjee, Shubhra Majumder, Yao Wan, Vijay Shah, Jingyan Wu, Hsiao-Yun Huang, Anita K Hopper
Eukaryotic transfer RNAs (tRNAs) are exported from the nucleus, their site of synthesis, to the cytoplasm, their site of function for protein synthesis. The evolutionarily conserved β-importin family member Los1 (Exportin-t) has been the only exporter known to execute nuclear export of newly transcribed intron-containing pre-tRNAs. Interestingly, LOS1 is unessential in all tested organisms. As tRNA nuclear export is essential, we previously interrogated the budding yeast proteome to identify candidates that function in tRNA nuclear export...
December 6, 2017: Genes & Development
https://www.readbyqxmd.com/read/29212358/a-mediation-analysis-of-mothers-dietary-intake-the-entre-familia-reflejos-de-salud-randomized-controlled-trial
#20
Lucy A Horton, Guadalupe X Ayala, Donald J Slymen, Leticia Ibarra, Erika Hernandez, Humberto Parada, Cheryl L Rock, Elva M Arredondo, John P Elder
AIMS: Examine intervention effects among mothers involved in a healthy eating randomized controlled trial. Furthermore, examine the mediating roles of individual and familial influences on observed outcomes. METHODS: Between 2009 and 2011, 361 families were recruited; half were assigned to an 11-session community health worker-delivered family-based intervention targeting Spanish-speaking Latino families in Imperial County, California. The intervention was delivered over a 4-month period...
December 1, 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
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