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https://www.readbyqxmd.com/read/29667562/caregiver-perceptions-of-a-fruit-and-vegetable-prescription-programme-for-low-income-paediatric-patients
#1
Amy Saxe-Custack, Heather Claire Lofton, Mona Hanna-Attisha, Colleen Victor, Gwendolyn Reyes, Tiffany Ceja, Jenny LaChance
OBJECTIVE: The physical and social environments that surround children should support good health. However, challenges with food security and access prevent many children from consuming a healthy diet, which is critical to proper growth and development. The present study sought to gain a better understanding of primary care initiatives to address these issues in a low-income setting. DESIGN: Following the relocation of a paediatric clinic to a farmers' market building and the implementation of a fruit and vegetable prescription programme, researchers conducted thirty-two semi-structured interviews with caregivers...
April 18, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29667264/metagenomic-analysis-of-oral-microbiome-in-young-children-aged-6-8-y-living-in-a-rural-isolated-chinese-province
#2
Yuan Xu, Yuhuan Jia, Liang Chen, Wenming Huang, Deqin Yang
BACKGROUND: The mixed dentition is an important transition period from primary teeth. to permanent teeth. However, the caries prevalence of first permanent molar in mixed dentitions was about 30%, which almost represent the caries rate of permanent teeth in this period of time. Therefore, we assessed the oral bacterial profiles in young children (age 6-8) with mixed dentition with or without first molar caries for providing the research basis of caries etiology. METHODS: We collected samples of supragingival plaque and saliva from the children living in Guizhou, a rural isolated province in China...
April 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29667166/disability-differentials-in-educational-attainment-in-england-primary-and-secondary-effects
#3
Stella Chatzitheochari, Lucinda Platt
Childhood disability has been largely overlooked in social stratification and life course research. As a result, we know remarkably little about mechanisms behind well-documented disability differentials in educational outcomes. This study investigates educational transitions of disabled youth using data from the Longitudinal Study of Young People in England. We draw on social stratification literature on primary and secondary effects as well as that on stigma and labelling in order to explain disabled young people's educational outcomes...
April 17, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29667151/ethical-and-legal-concerns-with-nevada-s-brain-death-amendments
#4
Greg Yanke, Mohamed Y Rady, Joseph L Verheijde
In early 2017, Nevada amended its Uniform Determination of Death Act (UDDA), in order to clarify the neurologic criteria for the determination of death. The amendments stipulate that a determination of death is a clinical decision that does not require familial consent and that the appropriate standard for determining neurologic death is the American Academy of Neurology's (AAN) guidelines. Once a physician makes such a determination of death, the Nevada amendments require the withdrawal of life-sustaining treatment within twenty-four hours with limited exceptions...
April 17, 2018: Journal of Bioethical Inquiry
https://www.readbyqxmd.com/read/29667147/effects-of-heyan-kuntai-capsule-on-follicular-development-and-oocyte-cohesin-levels-in-aged-mice
#5
Bin Zhang, Nan Chu, Xue-Min Qiu, Wei Tang, Hans-Jürgen Gober, Da-Jin Li, Ling Wang
OBJECTIVE: To evaluate the effect of Heyan Kuntai Capsule (, HYKT) on the ovarian function of aged mice and expressions of cohesion complexes in oocytes. METHODS: Twenty-five 9-month-old female C57BL/6J mice were randomly divided into 5 groups by block randomization method (n=5 per group), including the control group (saline), 17 β-estradiol group [E2 , 100 μg/(kg·d)], and low-, medium-, and high-dose of HYKT groups [0.3, 0.9, 2.7 g/(kg·d), respectively]. All mice were treated by intragastric administration for 4 weeks...
April 17, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29666096/devil-is-in-the-detail
#6
John Roshan Jacob, Amal Paul, Anoop George Alex
A 15-year-old girl of Asian origin, hailing from a rural agrarian background, presented with history of multiple episodes of dizziness for 3 years. The episodes were precipitated mostly by emotional and/or physical stress and relieved on lying down, with a few episodes culminating in transient loss of consciousness. As preliminary cardiac and neurological evaluation were normal, she was being treated by the primary physician as a case of probable psychogenic syncope, supported by the consistent association of the episodes with emotional stress...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29665951/statistical-considerations-for-pediatric-multidrug-resistant-tuberculosis-efficacy-trials
#7
S Kim, J A Seddon, A J Garcia-Prats, G Montepiedra
The inclusion of newly licensed or repurposed drugs in regimens to treat children for multidrug-resistant tuberculosis (TB) may lead to treatment that is shorter than traditional regimens and composed only of oral medications. As an all-oral regimen may be more acceptable and have a better safety profile than current regimens, demonstrating non-inferiority may be satisfactory. Demonstrating non-inferior efficacy requires setting a non-inferiority margin and safeguarding study assay sensitivity. Multi-arm, multistage designs may currently not be appropriate in pediatric trials because of the lack of sensitive and specific intermediate outcomes...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29665924/-analysis-of-phenotype-and-l12r-mutation-in-signal-peptide-and-3-non-translation-region-c11814-insaa-mutation-of-f7-gene-in-a-family-with-hereditary-coagulation-factor-vii-deficiency
#8
Shan Liu, Jing-Yu Zhang, Zheng-Rong Li, Yan Wang, Zhi-Yun Niu, Feng-Ru Lin
OBJECTIVE: To examine one young female patient with hereditary FVII deficiency and her family members, to observe the gene mutation and clinical phenotype, and to investigate the molecular mechanism of the dysfunction. METHODS: Prothrombin time (PT), activated partial thromoploastin time (APTT), fibrinogen (Fg) and FVII activity (FVII:C) and FVII antigen (FVII:Ag) were tested. The gene mutations were sought by DNA sequencing for all of the exons and flanks, 5' and 3' non-translation region of F7 gene...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665911/-clinical-analysis-of-refractory-primary-central-nervouse-system-lymphoma-treated-with-high-dose-mtx-based-chemotherapy-and-haploidentical-hematopoietic-stem-cell-infusion
#9
Juan Liu, Wan-Jun Sun, Xiao-Qin Xi, Xiao-Mei Huang, Xiao-Xi Li, Jiao Xia, Yuan-Yuan Qu
OBJECTIVE: To investigate the efficacy and safety of high-dose methotrexate-based chemotherapy combined with granulocyte-colony stimulating factor (G-CSF)-mobilized family related haploidentical donor peripheral blood hematopoietic stem cell (G-PBHSC) infusion for the treatment of patients with refractory primary central nervouse system lymphoma (PCNSL). METHODS: Three patients with refractory PCNSL were treated in Department of Hematology of the General Hospital of the PLA's Rocket Force from March 2014 to September 2015...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665702/current-weight-management-approaches-used-by-primary-care-providers-in-six-multidisciplinary-healthcare-settings-in-ontario
#10
Stephanie Aboueid, Monika Jasinska, Ivy Bourgeault, Isabelle Giroux
Background Obesity management in primary care has been suboptimal due to lack of access to allied health professionals, time, and resources. Purpose To understand the weight management approaches used by primary care providers working in team-based settings and how they assess the most suitable approach for a patient. Methods A total of 20 primary care providers (13 nurse practitioners and 7 family physicians) working in 6 multidisciplinary clinics in Ontario were interviewed. All interviews were recorded, transcribed verbatim, and coded using NVivo qualitative software...
January 1, 2018: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/29665585/-outpatient-emergency-care-for-nursing-home-residents-a-status-quo-from-a-nursing-perspective
#11
Markus Bleckwenn, Linnea Bell, Rieke Schnakenberg, Klaus Weckbecker, Manuela Klaschik
AIM OF THE STUDY: At present about 2 million people need care in Germany, about one third of them live in old people's homes or nursing homes. Outpatient emergency care of nursing home residents is ensured by primary care physicians, the medical emergency service and the emergency services. Emergency care has rarely been examined from the perspective of nurses. Therefore, in our study, we investigated how the nurses perceive medical care in medical emergencies and what suggestions for improvements they have...
April 17, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29665393/comparative-experimental-theoretical-studies-on-the-egfr-dimerization-under-the-effect-of-egf-egf-analogues-binding-highlighting-the-importance-of-egf-egfr-interactions-at-site-iii-interface
#12
Masomeh Mehrabi, Hamid Mahdiuni, Hassan Rasouli, Kamran Mansouri, Mohsen Shahlaie, Reza Khodarahmi
Epidermal growth factor receptors (EGFRs) and their cytoplasmic tyrosine kinases play significant roles in cell proliferation and signaling. All the members of the EGFR/ErbB family are primary goals for cancer therapy, particularly for tumors of breast, cervix, ovaries, kidney, esophagus, prostate and non-small-cell lung carcinoma and head and neck tumors. However, the therapeutic ability of accessible anti-ErbB agents is limited. Therefore, recognizing EGF analogues or small organic molecules with high affinity for the extracellular domain of the EGFR is a critical target on cancer research...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29665072/an-update-on-canine-cardiomyopathies-is-it-all-in-the-genes
#13
REVIEW
E Dutton, J López-Alvarez
Dilated cardiomyopathy is the second most common cardiac disease in dogs and causes considerable morbidity and mortality. Primary dilated cardiomyopathy is suspected to be familial, and genetic loci have been associated with the disease in a number of breeds. Because it is an adult-onset disease, usually with late onset, testing breeding dogs and bitches before breeding for a genetic mutation that could lead to dilated cardiomyopathy would be helpful to prevent disease. There is growing evidence that the genetic basis may be multigenic rather than monogenic in the majority of studied breeds...
April 17, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29665021/phylogenomics-reveals-an-extensive-history-of-genome-duplication-in-diatoms-bacillariophyta
#14
Matthew B Parks, Teofil Nakov, Elizabeth C Ruck, Norman J Wickett, Andrew J Alverson
PREMISE OF THE STUDY: Diatoms are one of the most species-rich lineages of microbial eukaryotes. Similarities in clade age, species richness, and primary productivity motivate comparisons to angiosperms, whose genomes have been inordinately shaped by whole-genome duplication (WGD). WGDs have been linked to speciation, increased rates of lineage diversification, and identified as a principal driver of angiosperm evolution. We synthesized a large but scattered body of evidence that suggests polyploidy may be common in diatoms as well...
April 17, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29664907/what-matters-to-women-during-childbirth-a-systematic-qualitative-review
#15
Soo Downe, Kenneth Finlayson, Olufemi Oladapo, Mercedes Bonet, A Metin Gülmezoglu
INTRODUCTION: Design and provision of good quality maternity care should incorporate what matters to childbearing women. This qualitative systematic review was undertaken to inform WHO intrapartum guidelines. METHODS: Using a pre-determined search strategy, we searched Medline, CINAHL, PsycINFO, AMED, EMBASE, LILACS, AJOL, and reference lists of eligible studies published 1996-August 2016 (updated to January 2018), reporting qualitative data on womens' childbirth beliefs, expectations, and values...
2018: PloS One
https://www.readbyqxmd.com/read/29662716/social-stigma-and-familial-attitudes-related-to-infertility
#16
Rahime Nida Ergin, Aslıhan Polat, Bülent Kars, Deniz Öztekin, Kenan Sofuoğlu, Eray Çalışkan
Objective: To determine the perceived social stigma and familial attitides and perception of sexuality in infertile couples attending infertility clinics. Materials and Methods: Infertile couples attending infertility clinics between the years of 2014 and 2015 were requested to complete detailed evaluation forms including questions related to the social stigma on their infertility, their familial attitudes, and perception of sexuality. Any partner of the infertile couple accepting to enroll in the study was given the evaluation forms...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29662658/cross-resistance-to-diverse-anticancer-nicotinamide-phosphoribosyltransferase-inhibitors-induced-by-fk866-treatment
#17
Yoko Ogino, Akira Sato, Fumiaki Uchiumi, Sei-Ichi Tanuma
Cross-resistance to drugs remains an unsolved problem in cancer chemotherapy. This study elucidates a molecular mechanism of cross-resistance to diverse inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) with anticancer activity. We generated a variant of the human colon cancer cell line HCT116, HCT116RFK866 , which exhibited primary resistance to the potent NAMPT inhibitor FK866, and was approximately 1,000-fold less sensitive to the drug than the parental HCT116. HCT116RFK866 was found to be cross-resistant to diverse NAMPT inhibitors, including CHS-828, GNE-617, and STF-118804...
March 27, 2018: Oncotarget
https://www.readbyqxmd.com/read/29662524/parent-only-group-cognitive-behavioral-intervention-for-children-with-anxiety-disorders-a-control-group-study
#18
Elham Salari, Zahra Shahrivar, Javad Mahmoudi-Gharaei, Elham Shirazi, Mitra Sepasi
Objective: Parents play an important role in development and continuation of anxiety disorders in children. Yet the evidence on parent contribution in cognitive behavioral therapy (CBT) for childhood anxiety is limited. This open randomized trial examined the effectiveness of a parent-directed group CBT to manage children with anxiety disorders. Method: Parents of 42 children aged 6-12 with primary anxiety disorders were allocated to a six, two-hour weekly intervention and a wait-list (WL) control...
April 2018: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29662521/evaluating-training-programs-for-primary-care-providers-in-child-adolescent-mental-health-in-canada-a-systematic-review
#19
Sandra Gotovac, Stacey Espinet, Reza Naqvi, Lorelei Lingard, Margaret Steele
Introduction: The need for child/adolescent mental health care in Canada is growing. Primary care can play a key role in filling this gap, yet most providers feel they do not have adequate training. This paper reviews the Canadian literature on capacity building programs in child and adolescent psychiatry for primary care providers, to examine how these programs are being implemented and evaluated to contribute to evidence-based initiatives. Methods: A systematic literature review of peer-reviewed published articles of capacity building initiatives in child/adolescent mental health care for primary care practitioners that have been implemented in Canada...
April 2018: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29662487/acquisition-of-n-glycosylation-sites-in-immunoglobulin-heavy-chain-genes-during-local-expansion-in-parotid-salivary-glands-of-primary-sj%C3%A3-gren-patients
#20
Annie Visser, Marieke E Doorenspleet, Niek de Vries, Fred K L Spijkervet, Arjan Vissink, Richard J Bende, Hendrika Bootsma, Frans G M Kroese, Nicolaas A Bos
Previous studies revealed high incidence of acquired N-glycosylation sites acquired N-glycosylation sites in RNA transcripts encoding immunoglobulin heavy variable region (IGHV) 3 genes from parotid glands of primary Sjögren's syndrome (pSS) patients. In this study, next generation sequencing was used to study the extent of ac-Nglycs among clonally expanded cells from all IGVH families in the salivary glands of pSS patients. RNA was isolated from parotid gland biopsies of five pSS patients and five non-pSS sicca controls...
2018: Frontiers in Immunology
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