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High intensity focused ultrasound

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https://www.readbyqxmd.com/read/28928042/effect-of-high-intensity-focused-ultrasound-hifu-in-conjunction-with-a-nanomedicines-microbubble-complex-for-enhanced-drug-delivery
#1
Hyounkoo Han, Hohyeon Lee, Kwangmeyung Kim, Hyuncheol Kim
Although nanomedicines have been intensively investigated for cancer therapy in the past, poor accumulation of nanomedicines in tumor sites remains a serious problem. Therefore, a novel drug delivery system is required to enhance accumulation and penetration of nanomedicines at the tumor site. Recently, high-intensity focused ultrasound (HIFU) has been highlighted as a non-invasive therapeutic modality, and showed enhanced therapeutic efficacy in combination with nanomedicines. Cavitation effect induced by the combination of HIFU and microbubbles results in transiently enhanced cell membrane permeability, facilitating improved drug delivery efficiency into tumor sites...
September 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28927782/development-and-internal-validation-of-prediction-models-for-biochemical-failure-and-composite-failure-after-focal-salvage-high-intensity-focused-ultrasound-for-local-radiorecurrent-prostate-cancer-presentation-of-risk-scores-for-individual-patient-prognoses
#2
Max Peters, Abi Kanthabalan, Taimur T Shah, Neil McCartan, Caroline M Moore, Manit Arya, Jochem R van der Voort van Zyp, Marinus A Moerland, Richard G Hindley, Mark Emberton, Hashim U Ahmed
PURPOSE: Patient selection for focal salvage remains difficult. Therefore, we developed and internally validated prediction models for biochemical failure (BF) and a composite endpoint (CE) following focal salvage high intensity focused ultrasound (HIFU) for radiorecurrent prostate cancer. MATERIALS AND METHODS: A prospective HIFU registry identified 150 cases (November 2006-August 2015). Recurrence was assessed with multiparametric magnetic resonance imaging (MRI) combined with template prostate mapping biopsies, targeted biopsies, or systematic transrectal ultrasound-guided biopsies...
September 15, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28926968/weakening-pin-bone-attachment-in-fish-fillets-using-high-intensity-focused-ultrasound
#3
Martin H Skjelvareid, Svein Kristian Stormo, Kristín Anna Þórarinsdóttir, Karsten Heia
High Intensity Focused Ultrasound (HIFU) can be used for the localized heating of biological tissue through the conversion of sound waves into heat. Although originally developed for human medicine, HIFU may also be used to weaken the attachment of pin bones in fish fillets to enable easier removal of such bones. This was shown in the present study, where a series of experiments were performed on HIFU phantoms and fillets of cod and salmon. In thin objects such as fish fillets, the heat is mainly dissipated at the surfaces...
September 18, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28924476/clinical-validation-of-real-time-tissue-change-monitoring-during-prostate-tissue-ablation-with-high-intensity-focused-ultrasound
#4
Narendra T Sanghvi, Wo-Hsing Chen, Roy Carlson, Clint Weis, Ralf Seip, Toyoaki Uchida, Michael Marberger
BACKGROUND: The purpose of these clinical studies was to validate a Tissue Change Monitoring (TCM) algorithm in vivo. TCM is a quantitative tool for the real-time assessment of HIFU dose. TCM provides quantitative analysis of the backscatter pulse echo signals (pre and immediately post HIFU) for each individual ablative site, using ultrasonic tissue characterization as a surrogate for monitoring tissue temperature. Real-time analysis generates an energy difference parameter (ΔE in dB) that is proportional to tissue temperature...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28917284/neurosurgical-applications-of-high-intensity-focused-ultrasound-with-magnetic-resonance-thermometry
#5
REVIEW
Rivka R Colen, Iman Sahnoune, Jeffrey S Weinberg
Magnetic resonance guided focused ultrasound surgery (MRgFUS) has potential noninvasive effects on targeted tissue. MRgFUS integrates MRI and focused ultrasound surgery (FUS) into a single platform. MRI enables visualization of the target tissue and monitors ultrasound-induced effects in near real-time during FUS treatment. MRgFUS may serve as an adjunct or replace invasive surgery and radiotherapy for specific conditions. Its thermal effects ablate tumors in locations involved in movement disorders and essential tremors...
October 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/28913353/the-effects-of-low-intensity-ultrasound-on-fat-reduction-of-rat-model
#6
Bill Zhou, Benny Yuk Kin Leung, Lei Sun
Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safety of this new technology by applying 1 MHz nonfocused ultrasound at 3 W/cm(2) to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28901969/disorders-of-consciousness-after-severe-brain-injury-therapeutic-options
#7
Caroline Schnakers, Martin M Monti
PURPOSE OF REVIEW: Very few options exist for patients who survive severe traumatic brain injury but fail to fully recover and develop a disorder of consciousness (e.g. vegetative state, minimally conscious state). RECENT FINDINGS: Among pharmacological approaches, Amantadine has shown the ability to accelerate functional recovery. Although with very low frequency, Zolpidem has shown the ability to improve the level of consciousness transiently and, possibly, also in a sustained fashion...
September 9, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28894936/thermal-ablation-of-thyroid-nodules-are-radiofrequency-ablation-microwave-ablation-and-high-intensity-focused-ultrasound-equally-safe-and-effective-methods
#8
Yücel Korkusuz, Daniel Gröner, Natascha Raczynski, Oleg Relin, Yasmina Kingeter, Frank Grünwald, Christian Happel
OBJECTIVES: This study compares volume reduction of benign thyroid nodules three months after Radiofrequency Ablation (RFA), Microwave Ablation (MWA) or High Intensity Focused Ultrasound (HIFU) to evaluate which of these methods is the most effective and safe alternative to thyroidectomy or radioiodine therapy. MATERIAL AND METHODS: Ninety-four patients (39 male, 55 female) with a total of 118 benign, symptomatic thyroid nodules were divided into three subgroups...
September 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28890088/management-of-local-relapse-after-prostate-cancer-radiotherapy-surgery-or-radiotherapy
#9
C Hennequin, J-M Hannoun-Lévi, F Rozet
Isolated local relapse after prostate cancer radiotherapy corresponds to 40% of biochemical failure. The management of these relapses is not well defined. Several strategies are available including surgery, high-intensity focused ultrasounds (HIFU), cryotherapy and reirradiation. Radical prostatectomy is the historical approach; biochemical control is obtained in 50 to 80% at 5 year. However, morbidity is higher after irradiation than as a first line treatment. Some limited series of HIFU and cryotherapy have been published with interesting results, but again the risk of urinary and rectal toxicity is high...
September 7, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28883630/a-clinical-investigation-treating-different-types-of-fibroids-identified-by-mri-t2wi-imaging-with-ultrasound-guided-high-intensity-focused-ultrasound
#10
Wen-Peng Zhao, Jing Zhang, Zhi-Yu Han, Jin-Peng Yao, Xiang Zhou, Ping Liang
Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This study aimed to evaluate the clinical safety and efficacy of ablating different types of fibroids, classified by T2-weighted magnetic resonance imaging (MRI-T2WI). Based on MRI-T2WI signal intensities, uterine fibroids were classified as three types: hypointensive (52 cases), isointensive (64 cases) and hyperintensive (56 cases)...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880170/rapid-spatial-mapping-of-focused-ultrasound-fields-using-a-planar-fabry-p%C3%A3-rot-sensor
#11
Eleanor Martin, Edward Z Zhang, James A Guggenheim, Paul C Beard, Bradley E Treeby
Measurement of high acoustic pressures is necessary in order to fully characterise clinical high-intensity focused ultrasound (HIFU) fields, and for accurate validation of computational models of ultrasound propagation. However, many existing measurement devices are unable to withstand the extreme pressures generated in these fields, and those that can often exhibit low sensitivity. Here, a planar Fabry-Pérot interferometer with hard dielectric mirrors and spacer was designed, fabricated, and characterised and its suitability for measurement of nonlinear focused ultrasound fields was investigated...
September 4, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28861994/on-demand-drug-release-from-dual-targeting-small-nanoparticles-triggered-by-high-intensity-focused-ultrasound-enhanced-glioblastoma-targeting-therapy
#12
Zimiao Luo, Kai Jin, Qiang Pang, Shun Shen, Zhiqiang Yan, Ting Jiang, Xiaoyan Zhu, Lei Yu, Zhiqing Pang, Xinguo Jiang
Glioblastoma is one of the most challenging and intractable tumors with the difficult treatment and poor prognosis. Unsatisfactory traditional systemic chemotherapies for glioblastoma are mainly attributed to the insufficient and nonspecific drug delivery into the brain tumors as well as the incomplete drug release at the tumor sites. Inspired by the facts that angiopep-2 peptide is an acknowledged dual-targeting moiety for brain tumor-targeting delivery and high-intensity focused ultrasound (HIFU) is an ideal trigger for drug release with an ultrahigh energy and millimeter-sized focus ability, in the present study, a novel HIFU-responsive angiopep-2-modified small poly(lactic-co-glycolic acid) (PLGA) hybrid nanoparticle (NP) drug delivery system holding doxorubicin/perfluorooctyl bromide (ANP-D/P) was designed to increase the intratumoral drug accumulation, further trigger on-demand drug release at the glioblastoma sites, and enhance glioblastoma therapy...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28856867/changes-in-anti-m%C3%A3-llerian-hormone-levels-as-a-biomarker-for-ovarian-reserve-after-ultrasound-guided-high-intensity-focused-ultrasound-treatment-of-adenomyosis-and-uterine-fibroid
#13
J-S Lee, G-Y Hong, K-H Lee, T-E Kim
OBJECTIVE: To assess the changes in antimüllerian hormone (AMH) levels after ablation for symptomatic uterine fibroids and adenomyosis using ultrasound-guided high-intensity focused ultrasound (USgHIFU). DESIGN: A prospective study. SETTING: Gynaecological department in multiple hospitals in South Korea. POPULATION: Patients with uterus fibroids and adenomyosis. METHODS: Seventy-nine women with symptomatic uterine fibroids and adenomyosis who met the inclusion criteria were enrolled in our study between January 2014 and December 2014...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856866/a-comparison-of-the-cost-utility-of-ultrasound-guided-high-intensity-focused-ultrasound-and-hysterectomy-for-adenomyosis-a-retrospective-study
#14
X F Liu, L H Huang, C Zhang, G H Huang, L M Yan, J He
OBJECTIVE: To evaluate cost-effectiveness of ultrasound-guided high-intensity focused ultrasound (USgHIFU) and open hysterectomy for adenomyosis. DESIGN: A retrospective analysis. SETTING: Gynaecological department in a single centre in China. POPULATION: Patients with symptomatic adenomyosis. MAIN OUTCOME MEASURES: Cost difference between patients with adenomyosis treated with USgHIFU and open hysterectomy...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856864/pregnancy-outcomes-in-patients-with-uterine-fibroids-treated-with-ultrasound-guided-high-intensity-focused-ultrasound
#15
M Zou, L Chen, C Wu, C Hu, Y Xiong
OBJECTIVE: To investigate the effect of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids on pregnancy. DESIGN: A retrospective observational study. SETTING: Department of Gynaecology in a single centre in China. POPULATION: Patients with uterine fibroids who wish to become pregnant. METHODS: Patients with uterine fibroids who wished become pregnant and have children, were treated using HIFU from April 2011 to March 2016 at Chongqing Haifu Hospital...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856862/gonadotrophin-releasing-hormone-agonist-combined-with-high-intensity-focused-ultrasound-ablation-for-adenomyosis-a-clinical-study
#16
Y Guo, H Duan, J Cheng, Y Zhang
OBJECTIVES: This study was to investigate the clinical efficacy of a gonadotrophin-releasing hormone agonist (GnRH-a) combined with high-intensity focused ultrasound (HIFU) ablation treatment for adenomyosis. DESIGN: A non-randomized prospective study. SETTING: Gynaecological Minimally Invasive Centre in a single hospital. POPULATION: Patients with adenomyosis. METHODS: Seventy-nine patients with adenomyosis were enrolled, including 55 patients in the control group treated with only HIFU and 24 patients in the study group treated with GnRH-a combined with HIFU...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856861/high-intensity-focused-ultrasound-combined-with-hysteroscopic-resection-for-the-treatment-of-placenta-accreta
#17
M Ye, Z Yin, M Xue, X Deng
OBJECTIVE: The aim of this study was to evaluate the safety and efficacy of a combination of high-intensity focused ultrasound (HIFU) and hysteroscopic resection while treating placenta accreta (PA). DESIGN: A retrospective study. SETTING: A university teaching hospital in China. METHODS: This study included 25 patients diagnosed with PA who underwent HIFU followed by hysteroscopic resection in our hospital between January 2014 and December 2015...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856860/the-effect-of-exercise-on-high-intensity-focused-ultrasound-treatment-efficacy-in-uterine-fibroids-and-adenomyosis-a-retrospective-study
#18
X Huang, D Yu, M Zou, L Wang, H R Xing, Z Wang
OBJECTIVE: We conducted a retrospective study to evaluate whether exercise after high-intensity focused ultrasound (HIFU) treatment can improve the absorption of uterine fibroids and the relief of dysmenorrhea caused by adenomyosis. DESIGN: A retrospective study. SETTING: Gynaecological department of a single centre in China. POPULATION: Patients with uterine fibroids and adenomyosis. METHOD: From January 2011 to August 2015,83 MRI-confirmed uterine fibroid patients and 102 adenomyosis patients who received HIFU treatment at Chongqing Haifu Hospital and attended the 1-year and 6-month follow up, respectively, were included in our retrospective study...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856859/a-comparison-between-high-intensity-focused-ultrasound-and-surgical-treatment-for-the-management-of-abdominal-wall-endometriosis
#19
X Zhu, L Chen, X Deng, S Xiao, M Ye, M Xue
OBJECTIVE: The aim of this study was to compare the therapeutic outcomes of high-intensity focused ultrasound (HIFU) and surgical treatment for abdominal wall endometriosis. DESIGN: A retrospective study. SETTING: Gynaecological department of a teaching hospital in China. POPULATION: Patients with abdominal wall endometriosis. METHODS: Among the 51 patients, 23 patients were treated with ultrasound-guided HIFU and 28 patients with surgery...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28856858/enhancing-ablation-effects-of-a-microbubble-contrast-agent-on-high-intensity-focused-ultrasound-an-experimental-and-clinical-study
#20
C Cheng, Z Xiao, G Huang, L Zhang, J Bai
OBJECTIVE: To investigate the relationship between SonoVue ablation enhancement effects on high-intensity focused ultrasound (HIFU) and the concentration of SonoVue and timing of HIFU. DESIGN: Two randomised controlled trials. SETTING: An animal centre in a university and a gynaecological department in a university hospital in China. POPULATION OR SAMPLE: 63 rabbits and 143 patients with a solitary uterine fibroid...
August 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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