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High intensity focused ultrasound

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https://www.readbyqxmd.com/read/29161715/management-of-biochemical-recurrence-after-primary-curative-treatment-for-prostate-cancer-a-review
#1
Walter Artibani, Antonio Benito Porcaro, Vincenzo De Marco, Maria A Cerruto, Salvatore Siracusano
How to manage patients with prostate cancer (PCa) with biochemical recurrence (BCR) following primary curative treatment is a controversial issue. Importantly, this prostate-specific antigen (PSA)-only recurrence is a surrogate neither of PCa-specific survival nor of overall survival. Physicians are therefore challenged with preventing or delaying the onset of clinical progression in those deemed at risk, while avoiding over-treating patients whose disease may never progress beyond PSA-only recurrence. Adjuvant therapy for radical prostatectomy (RP) or local radiotherapy (RT) has a role in certain at-risk patients, although it is not recommended in low-risk PCa owing to the significant side-effects associated with RT and androgen deprivation therapy (ADT)...
November 21, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29161293/high-intensity-focused-ultrasound-ablation-around-the-tubing
#2
Jun Yang Siu, Chenhui Liu, Yufeng Zhou
High-intensity focused ultrasound (HIFU) has been emerging as an effective and noninvasive modality in cancer treatment with very promising clinical results. However, a small vessel in the focal region could be ruptured, which is an important concern for the safety of HIFU ablation. In this study, lesion formation in the polyacrylamide gel phantom embedded with different tubing (inner diameters of 0.76 mm and 3 mm) at varied flow speeds (17-339 cm/s) by HIFU ablation was photographically recorded. Produced lesions have decreased length (~30%) but slightly increased width (~6%) in comparison to that without the embedded tubing...
2017: PloS One
https://www.readbyqxmd.com/read/29160777/motion-compensation-with-skin-contact-control-for-high-intensity-focused-ultrasound-surgery-in-moving-organs
#3
Alessandro Diodato, Andrea Cafarelli, Andrea Schiappacasse, Selene Tognarelli, Gastone C Ciuti, Arianna Menciassi
High Intensity Focused Ultrasound (HIFU) is an emerging therapeutic solution that enables non-invasive treatment of several pathologies, mainly in oncology. On the other hand, accurate targeting of moving abdominal organs (e.g., liver, kidney, pancreas) is still an open challenge. This paper proposes a novel method to compensate the physiological respiratory motion of organs during HIFU procedures, by exploiting a robotic platform for ultrasound-guided HIFU surgery provided with a therapeutic annular phased array transducer...
November 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29160427/review-of-magnetic-resonance-guided-focused-ultrasound-in-the-treatment-of-uterine-fibroids
#4
Pedro Felipe Magalhães Peregrino, Marcos de Lorenzo Messina, Ricardo Dos Santos Simões, José Maria Soares-Júnior, Edmund Chada Baracat
Uterine leiomyoma is the most frequently occurring solid pelvic tumor in women during the reproductive period. Magnetic resonance-guided high-intensity focused ultrasound is a promising technique for decreasing menorrhagia and dysmenorrhea in symptomatic women. The aim of this study is to review the role of Magnetic resonance-guided high-intensity focused ultrasound in the treatment of uterine fibroids in symptomatic patients. We performed a review of the MEDLINE and Cochrane databases up to April 2016. The analysis and data collection were performed using the following keywords: Leiomyoma, High-Intensity Focused Ultrasound Ablation, Ultrasonography, Magnetic Resonance Imaging, Menorrhagia...
October 2017: Clinics
https://www.readbyqxmd.com/read/29157478/treatment-of-low-flow-vascular-malformations-of-the-extremities-using-mr-guided-high-intensity-focused-ultrasound-preliminary-experience
#5
Pejman Ghanouni, Sirish Kishore, Matthew P Lungren, Rachelle Bitton, Lauren Chan, Raffi Avedian, Alberto Bazzocchi, Kim Butts Pauly, Alessandro Napoli, David M Hovsepian
Five patients with painful vascular malformations of the extremities that were refractory to standard treatment and were confirmed as low-flow malformations on dynamic contrast-enhanced magnetic resonance (MR) imaging were treated with MR imaging-guided high intensity focused ultrasound. Daily maximum numeric rating scale scores for pain improved from 8.4 ± 1.5 to 1.6 ± 2.2 (P = .004) at a median follow-up of 9 months (range, 4-36 mo). The size of the vascular malformations decreased on follow-up MR imaging (median enhancing volume, 8...
December 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29155701/an-ultrasonic-tool-for-nerve-conduction-block-in-diabetic-rat-models
#6
Yee Fun Lee, Chou-Ching Lin, Jung-Sung Cheng, Gin-Shin Chen
Nerve conduction block with a high intensity-focused ultrasound (HIFU) transducer has been performed in normal and diabetic animal models recently. HIFU can reversibly block the conduction of peripheral nerves without damaging the nerves while using an appropriate ultrasonic parameter. Temporary and partial block of the action potentials of nerves shows that HIFU has the potential to be a useful clinical treatment for pain relief. This work demonstrates the procedures for suppressing the action potentials of neuropathic nerves in diabetic rats in vivo using an HIFU transducer...
October 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29153363/uterine-fibroids-influence-of-t2-rim-sign-on-immediate-therapeutic-responses-to-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-ablation
#7
Sin Yuin Yeo, Young-Sun Kim, Hyo Keun Lim, Hyunchul Rhim, Sin-Ho Jung, Na Young Hwang
OBJECTIVES: To investigate the influence of a high-signal-intensity peripheral rim on T2-weighted MR images (i.e., T2-rim sign) on the immediate therapeutic responses of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids. METHODS: This retrospective study was approved by the institutional review board, and patient informed consent was obtained for MR-HIFU ablation. In total, 196 fibroids (diameter 6.2±2.6cm) in 123 women (age 43...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29137800/passive-acoustic-mapping-of-cavitation-using-eigenspace-based-robust-capon-beamformer-in-ultrasound-therapy
#8
Shukuan Lu, Hong Hu, Xianbo Yu, Jiangying Long, Bowen Jing, Yujin Zong, Mingxi Wan
Pulse-echo imaging technique can only play a role when high intensity focused ultrasound (HIFU) is turned off due to the interference between the primary HIFU signal and the transmission pulse. Passive acoustic mapping (PAM) has been proposed as a tool for true real-time monitoring of HIFU therapy. However, the most-used PAM algorithm based on time exposure acoustic (TEA) limits the quality of cavitation image. Recently, robust Capon beamformer (RCB) has been used in PAM to provide improved resolution and reduced artifacts over TEA-based PAM, but the presented results have not been satisfactory...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29137770/numerical-investigation-of-the-inertial-cavitation-threshold-under-multi-frequency-ultrasound
#9
Dingjie Suo, Bala Govind, Shengqi Zhang, Yun Jing
Through the introduction of multi-frequency sonication in High Intensity Focused Ultrasound (HIFU), enhancement of efficiency has been noted in several applications including thrombolysis, tissue ablation, sonochemistry, and sonoluminescence. One key experimental observation is that multi-frequency ultrasound can help lower the inertial cavitation threshold, thereby improving the power efficiency. However, this has not been well corroborated by the theory. In this paper, a numerical investigation on the inertial cavitation threshold of microbubbles (MBs) under multi-frequency ultrasound irradiation is conducted...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29107031/prospective-multicenter-phase-ii-study-on-focal-therapy-hemiablation-of-the-prostate-with-high-intensity-focused-ultrasound-hifu
#10
Roman Ganzer, Boris Hadaschik, Sascha Pahernik, Daniel Koch, Daniel Baumunk, Timur Kuru, Axel Heidenreich, Jens-Uwe Stolzenburg, Martin Schostak, Andreas Blana
PURPOSE: To evaluate Focal therapy (FT) by means of high-intensity focussed ultrasound (HIFU) hemiablation in a prospective trial. MATERIALS AND METHODS: Prospective multicentre single arm study in patients with unilateral low/intermediate risk PC, treated from April 2013 through March 2016 in Germany (AUO study protocol AP 68/11). Unilateral PC was assessed by transrectal ultrasound (TRUS)-guided biopsy and multiparametric magnetic resonance imaging (mpMRI). Hemiablation was performed with the Ablatherm or Focal One device...
October 26, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29103291/current-and-future-uses-of-transcranial-focused-ultrasound-in-neurosurgery
#11
David S Hersh, Howard M Eisenberg
Focused ultrasound (FUS) produces a region of high intensity at the focal zone of the beam but with minimal effects at adjacent areas, allowing the sonication of deep targets throughout the body. Despite early obstacles to transmitting ultrasound energy through the skull, recent advances in ultrasound technology, software, and real-time monitoring have resulted in a renewed interest in the clinical applications of transcranial FUS. Following extensive pre- clinical studies, ultrasound-induced thermal ablation has been approved by several countries for the treatment of essential tremor, Parkinson's disease, obsessive-compulsive disorder, depression, and neuropathic pain...
November 3, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29098986/gold-nanoparticle-nucleated-cavitation-for-enhanced-high-intensity-focused-ultrasound-therapy
#12
James R McLaughlan, David M J Cowell, Steven Freear
High intensity focused ultrasound (HIFU) or focused ultrasound surgery (FUS) is a non-invasive technique for the treatment of cancerous tissue, which is limited by difficulties in getting real-time feedback on treatment progress and long treatment durations. The formation and activity of acoustic cavitation, specifically inertial cavitation, during HIFU exposures has been demonstrated to enhance heating rates. However, without the introduction of external nuclei its formation an activity can be unpredictable, and potentially counterproductive...
November 3, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29091474/pilot-study-safety-and-effectiveness-of-simple-ultrasound-guided-high-intensity-focused-ultrasound-ablating-uterine-leiomyoma-with-a-diameter-greater-than-10%C3%A2-cm
#13
Ruijie Hou, Liwei Wang, Shaoping Li, Fengmin Rong, Yuanyuan Wang, Xuena Qin, Shijin Wang
OBJECTIVE: The study aimed to prospectively investigate whether uterine leiomyoma greater than 10 cm in diameter could be treated with simple ultrasound-guided high-intensity focused ultrasound (USgHIFU) in one-time treatment. METHODS: A total of 36 patients with 36 symptomatic uterine leiomyoma greater than 10 cm in diameter who underwent simple USgHIFU treatment alone were analysed. Enhanced MRI was performed before and after HIFU treatment, and all patients had follow-up for 6 months after treatment...
November 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29077784/effects-of-high-intensity-focused-ultrasound-on-cisplatin-resistant-human-lung-adenocarcinoma-in-vitro-and-in-vivo
#14
Tao Zhang, Libin Chen, Shengmin Zhang, Youfeng Xu, Yabo Fan, Lizhong Zhang
It is widely accepted that high-intensity focused ultrasound (HIFU) is a minimally invasive treatment option for different tumors, but its roles and the corresponding mechanism in cisplatin (DDP) chemoresistance in lung adenocarcinoma (LA) remain unclear. In this study, we investigated the response of DDP-resistant LA cells to HIFU and its underlying molecular mechanisms using molecular biology techniques. It was found that HIFU exposure inhibited the proliferation of DDP-resistant A549 (A549/DDP) cells through arresting cell cycle at the G1/G0 phase via the Cyclin-dependent pathway and promoting apoptosis in a Bcl-2-dependent manner...
October 25, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29076274/transcranial-mri-guided-high-intensity-focused-ultrasound-for-treatment-of-essential-tremor-a-pilot-study-on-the-correlation-between-lesion-size-lesion-location-thermal-dose-and-clinical-outcome
#15
Christian Federau, Maged Goubran, Jarrett Rosenberg, Jaimie Henderson, Casey H Halpern, Veronica Santini, Max Wintermark, Kim Butts Pauly, Pejman Ghanouni
BACKGROUND: Transcranial MR-guided high-intensity focused ultrasound (tcMRgFUS) is a promising noninvasive method to treat medication-refractory essential tremor. PURPOSE/HYPOTHESIS: To define the correlation between lesion size after ablation, thermal dose, and clinical outcome in tcMRgFUS treatment of essential tremor. STUDY TYPE: Retrospective. POPULATION/SUBJECTS/PHANTOM/SPECIMEN/ANIMAL MODEL: Eight patients with medication-refractory essential tremor were treated using a tcMRgFUS system at 3T...
October 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29074273/real-time-spatiotemporal-control-of-high-intensity-focused-ultrasound-thermal-ablation-using-echo-decorrelation-imaging-in-ex-vivo-bovine-liver
#16
Mohamed A Abbass, Jakob K Killin, Neeraja Mahalingam, Fong Ming Hooi, Peter G Barthe, T Douglas Mast
The ability to control high-intensity focused ultrasound (HIFU) thermal ablation using echo decorrelation imaging feedback was evaluated in ex vivo bovine liver. Sonications were automatically ceased when the minimum cumulative echo decorrelation within the region of interest exceeded an ablation control threshold, determined from preliminary experiments as -2.7 (log-scaled decorrelation per millisecond), corresponding to 90% specificity for local ablation prediction. Controlled HIFU thermal ablation experiments were compared with uncontrolled experiments employing two, five or nine sonication cycles...
October 23, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29074037/high-intensity-focused-ultrasound-therapy
#17
REVIEW
Vincent Y T Cheung
High-intensity focused ultrasound therapy has received increasing interest in the management of benign uterine tumors. Either magnetic resonance or ultrasound imaging has been used to target and monitor the ablation process. This article provides an overview of the background, clinical use, treatment outcomes, and safety of high-intensity focused ultrasound in the treatment of uterine fibroids and adenomyosis, including a summary of clinical trials comparing magnetic resonance- or ultrasound-guided high-intensity focused ultrasound with other minimally invasive or surgical interventions...
October 3, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29065623/segmentation-method-for-magnetic-resonance-guided-high-intensity-focused-ultrasound-therapy-planning
#18
A Vargas-Olivares, O Navarro-Hinojosa, M Maqueo-Vicencio, L Curiel, M Alencastre-Miranda, J E Chong-Quero
High-intensity focused ultrasound (HIFU) is a minimally invasive therapy modality in which ultrasound beams are concentrated at a focal region, producing a rise of temperature and selective ablation within the focal volume and leaving surrounding tissues intact. HIFU has been proposed for the safe ablation of both malignant and benign tissues and as an agent for drug delivery. Magnetic resonance imaging (MRI) has been proposed as guidance and monitoring method for the therapy. The identification of regions of interest is a crucial procedure in HIFU therapy planning...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29060151/optimization-of-transcostal-phased-array-refocusing-using-sparse-semidefinite-relaxation-method
#19
Mohamed Almekkawy, Daniel McMahon, Hanan Alqarni, Jiayu He
Treating tumors in organs shadowed by the ribs is a challenge for high intensity focused ultrasound (HIFU). The ribs absorb energy from the ultrasound beams causing their temperature to rise, while also distorting the beams, and limiting the target heat deposition. Accordingly, it is necessary to devise focusing methods that address the difficulties presented by the ribs. In this paper, a new approach that reduces total power deposition on the region of interest (ROI) by removing transducer elements is introduced...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059847/low-intensity-focused-ultrasound-stimulator-using-focal-depth-controller-for-improved-targeting-in-neuromuscular-rehabilitation
#20
Sungjin Oh, Dong Hwee Kim, Inchan Youn
Low-intensity ultrasound can be used for noninvasive neuromuscular stimulation to enhance the recovery of injured peripheral nerves and muscles. In order to improve the stimulation efficiency, focused ultrasound (FUS) with a high energy density should be used. Because the FUS is concentrated at a miniaturized focal area, deliberate targeting with focal depth control is required to achieve the accurate stimulation. In this study, a low-intensity focused ultrasound (LIFU) stimulator with a focal depth controller is presented as an effective ultrasound stimulation system for the neuromuscular rehabilitation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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