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High intensity focused ultrasound

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https://www.readbyqxmd.com/read/29778401/high-intensity-focused-ultrasound-the-fundamentals-clinical-applications-and-research-trends
#1
I A Shehata Elhelf, H Albahar, U Shah, A Oto, E Cressman, M Almekkawy
Diagnostic ultrasound has been clinically used for decades. More recently, high intensity focused ultrasound (HIFU) has been developed for therapeutic use as a non-invasive technique for tissue ablation. HIFU is also being investigated for advanced applications at the cellular level. Under guidance by magnetic resonance or ultrasound imaging, HIFU can achieve precise biological effects in tissue with a high safety profile. In this article, we discuss the basic principles, advantages and limitations of HIFU...
May 17, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29774894/value-of-diffusion-weighted-imaging-for-monitoring-tissue-change-during-magnetic-resonance-guided-high-intensity-focused-ultrasound-therapy-in-bone-applications-an-ex-vivo-study
#2
Sharon L Giles, Jessica M Winfield, David J Collins, Ian Rivens, John Civale, Gail R Ter Haar, Nandita M deSouza
Background: Magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) can palliate metastatic bone pain by periosteal neurolysis. We investigated the value of diffusion-weighted imaging (DWI) for monitoring soft tissue changes adjacent to bone during MR-guided HIFU. We evaluated the repeatability of the apparent diffusion coefficient (ADC) measurement, the temporal evolution of ADC change after sonication, and its relationship with thermal parameters. Methods: Ex-vivo experiments in lamb legs ( n = 8) were performed on a Sonalleve MR-guided HIFU system...
2018: European radiology experimental
https://www.readbyqxmd.com/read/29774832/intense-focus-of-alveolar-echinococcosis-south-kyrgyzstan
#3
Bakhadyr Bebezov, Nurlan Mamashev, Tilek Umetaliev, Iskender Ziadinov, Philip S Craig, Deborah E Joekel, Peter Deplazes, Felix Grimm, Paul R Torgerson
Human alveolar echinococcosis (AE) is a highly pathogenic zoonotic parasitic disease caused by Echinococcus multilocularis. An ultrasound study in southern Kyrgyzstan during 2012 revealed a prevalence of 4.2% probable or confirmed AE and an additional 2.2% possible AE, representing an emerging situation. The risk for probable or confirmed AE was significantly higher in dog owners.
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29773521/-treatment-of-fibroadenomas-by-high-intensity-focused-ultrasound-what-results-review
#4
K Guillez, R Callec, O Morel, T Routiot, C Mezan de Malartic
OBJECTIVES: To assess benefits and adverse effects of high-intensity focused ultrasound (HIFU) as a treatment for fibroadenomas (FA). METHODS: To ensure the quality of the methodology, the PRISMA criteria have been met at all stages of the development of this review. We searched MEDLINE from inception to May 2017, without any restriction. KEYWORDS: fibroadenoma, focused ultrasound, HIFU and fibroadenomata were used. Data were extracted and the results were compared...
May 14, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29772066/3d-specific-absorption-rate-estimation-from-high-intensity-focused-ultrasound-sonications-using-the-green-s-function-heat-kernel
#5
Nicholas J Freeman, Henrik Odéen, Dennis L Parker
PURPOSE: Evaluate a numerical inverse Green's function method of deriving specific absorption rates (SARs) from high intensity focused ultrasound (HIFU) sonications given tissue parameters (thermal conductivity, specific heat capacity, and mass density) and 3-D magnetic resonance imaging (MRI) temperature measurements. METHODS: SAR estimates were evaluated using simulations and MR temperature measurements from HIFU sonications. For simulations, a "true" SAR was calculated using the hybrid angular spectrum method for ultrasound simulations...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29771696/the-future-of-anesthesia-for-interventional-radiology
#6
Annie Amin, Jason Scott Lane
PURPOSE OF REVIEW: To review novel procedures in interventional radiology and describe anesthetic implications. RECENT FINDINGS: Noninvasive treatment options for patients who are nonsurgical candidates are on the rise. The complication rate for patients receiving anesthesia in the interventional radiology suite is higher than other nonoperating room anesthetizing locations. The investigative use of catheter-directed thrombolysis for acute submassive pulmonary embolism will likely lead to an increased demand for anesthesia assistance...
May 15, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29763486/update-on-noninvasive-body-contouring-techniques
#7
Alexandra K Rzepecki, Aaron S Farberg, Peter W Hashim, Gary Goldenberg
Noninvasive body contouring is the fastest growing area of cosmetic dermatology. It entails the use of specific technology to optimize the definition, smoothness, and shape of the human body in a safe and effective manner. There are currently 4 leading modalities used for noninvasive body contouring: cryolipolysis, radiofrequency, high-intensity focused ultrasound, and laser therapy. This article provides an overview of each modality.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29761991/-study-of-neuronal-spike-frequency-adaptation-with-transcranial-magneto-acoustical-stimulation
#8
Yi Yuan, Na Pang, Yudong Chen, Hongbao Sun, Xiaoli Li
Transcranial magneto-acoustical stimulation (TMAS), utilizing focused ultrasound and a magnetostatic field to generate an electric current in tissue fluid to regulate the activities of neurons, has high spatial resolution and penetration depth. The neuronal spike-frequency adaptation plays an important role in the treatment of neural information. In this paper, we study the effects of ultrasonic intensity, magnetostatic field intensity and ultrasonic frequency on the neuronal spike-frequency adaptation based on the Ermentrout neuron model...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29759425/simultaneous-evaluation-of-thermal-and-non-thermal-effects-of-high-intensity-focused-ultrasound-on-a-tissue-mimicking-phantom
#9
Yong Tae Kim, Donghee Ma, Jai Kyoung Sim, Se-Hwa Kim
Physiologically relevant phantoms with high reliability are essential for extending the therapeutic applications of high-intensity therapeutic ultrasound. Here we describe a tissue-mimicking phantom capable of quantifying temperature changes and observing non-thermal phenomena by high-intensity therapeutic ultrasound. Using polydiacetylene liposomes, we fabricated agar-based polydiacetylene hydrogel phantoms (PHPs) that not only respond to temperature, but also have acoustic properties similar to those of human liver tissue...
May 11, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29756298/primary-whole-gland-ablation-for-localized-prostate-cancer-with-high-intensity-focused-ultrasound-the-important-predictors-of-biochemical-recurrence
#10
Po Yen Chen, Po Hui Chiang, Yi Yang Liu, Yao Chi Chuang, Yuan Tso Cheng
OBJECTIVES: To identify predictive factors of biochemical recurrence for patients undergoing high-intensity focused ultrasound treatment for localized prostate cancer. METHODS: We retrospectively identified patients receiving whole-gland prostate ablation with high-intensity focused ultrasound for localized prostate cancer from 2009 to 2015. All the patients received pre-high-intensity focused ultrasound radical transurethral resection of the prostate. We included perioperative parameters as follows: age, preoperative prostate volume, stage of operation, initial prostate-specific antigen, T stage, postoperative prostate-specific antigen nadir, Gleason score, time to prostate-specific antigen nadir and the presence of prostate-specific antigen biochemical recurrence...
May 13, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29752231/temporal-neuromodulation-of-retinal-ganglion-cells-by-low-frequency-focused-ultrasound-stimulation
#11
Qiuju Jiang, Guofeng Li, Huixia Zhao, Wenlong Sheng, Lan Yue, Min Su, Shijun Weng, Leanne Lai-Hang Chan, Qifa Zhou, Mark S Humayun, Weibao Qiu, Hairong Zheng
Significant progress has been made recently in treating neurological blindness using implantable visual prostheses. However, implantable medical devices are highly invasive and subject to many safety, efficacy, and cost issues. The discovery that ultrasound (US) may be useful as a noninvasive neuromodulation tool has aroused great interest in the field of acoustic retinal prostheses (ARPs). We have investigated the responsiveness of rat retinal ganglion cells (RGCs) to low-frequency focused US stimulation (LFUS) at 2...
May 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29743538/which-technology-to-select-for-primary-focal-treatment-of-prostate-cancer-european-section-of-urotechnology-esut-position-statement
#12
REVIEW
Roman Ganzer, Vinodh Kumar Adithyaa Arthanareeswaran, Hashim U Ahmed, Andrea Cestari, Pascal Rischmann, Georg Salomon, Dogu Teber, Evangelos Liatsikos, Jens-Uwe Stolzenburg, Eric Barret
BACKGROUND: With growing interest in focal therapy (FT) of prostate cancer (PCa) there is an increasing armamentarium of treatment modalities including high-intensity focused ultrasound (HIFU), cryotherapy, focal laser ablation (FLA), irreversible electroporation (IRE), vascular targeted photodynamic therapy (VTP), focal brachytherapy (FBT) and stereotactic ablative radiotherapy (SABR). Currently there are no clear recommendations as to which of these technologies are appropriate for individual patient characteristics...
May 9, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29741290/comparison-of-high-intensity-focused-ultrasound-and-radioiodine-for-treating-toxic-thyroid-nodules
#13
Luca Giovanella, Arnoldo Piccardo, Cinzia Pezzoli, Fabiano Bini, Riccardo Ricci, Teresa Ruberto, Pierpaolo Trimboli
PURPOSE: We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary endpoint; concurrent changes in nodules' volume and scintigraphic pattern were also evaluated as secondary endpoints. MATERIALS AND METHODS: Among patients ≥18 years old with TTN observed at our centre between January 1st , 2016 and December 31th , 2016 we prospectively enrolled 17 and 15 age and sex-matched patients treated with RAI and HIFU, respectively...
May 9, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29733278/design-and-characterization-of-an-acoustically-and-structurally-matched-3-d-printed-model-for-transcranial-ultrasound-imaging
#14
Chen Bai, Meiling Ji, Ayache Bouakaz, Yujin Zong, Mingxi Wan
For investigating human transcranial ultrasound imaging (TUI) through the temporal bone, an intact human skull is needed. Since it is complex and expensive to obtain one, it requires that experiments are performed without excision or abrasion of the skull. Besides, to mimic blood circulation for the vessel target, cellulose tubes generally fit the vessel simulation with straight linear features. These issues, which limit experimental studies, can be overcome by designing a 3-D-printed skull model with acoustic and dimensional properties that match a real skull and a vessel model with curve and bifurcation...
May 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29733103/improvement-in-abdominal-and-flank-contouring-by-a-novel-adipocyte-selective-non-contact-radiofrequency-device
#15
Sun Young Choi, Young Jae Kim, So Yeon Kim, Woo Jin Lee, Sung Eun Chang, Mi Woo Lee, Jee Ho Choi, Chonghyun Won
BACKGROUND: The demand for undergoing subcutaneous fat reduction has been gradually increasing, and there are many methods and devices for performing non-surgical and non-invasive fat reduction, such as high-intensity focused ultrasound, cryolipolysis, radiofrequency (RF) devices, and lasers. OBJECTIVES: This study evaluated the efficacy and safety of a novel adipocyte-selective non-contact RF device for improving abdominal contouring in Asian subjects. METHODS: Twenty-four Asian subjects with abundant subcutaneous abdominal and love handle fat tissues were enrolled in this prospective clinical study...
May 7, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29723616/image-guided-thermosensitive-liposomes-for-focused-ultrasound-drug-delivery-using-nirf-labelled-lipids-and-topotecan-to-visualise-the-effects-of-hyperthermia-in-tumours
#16
Miguel N Centelles, Michael Wright, Po-Wah So, Maral Amrahli, Xiao Yun Xu, Justin Stebbing, Andrew D Miller, Wladyslaw Gedroyc, Maya Thanou
Image guided drug delivery using imageable thermosensitive liposomes (iTSLs) and high intensity focused ultrasound (FUS or HIFU) has attracted interest as a novel and non-invasive route to targeted delivery of anti-cancer therapeutics. FUS-induced hyperthermia is used as an externally applied "trigger" for the release of a drug cargo from within thermosensitive drug carriers. It is suggested that sub-ablative hyperthermia significantly modifies the permeability of tumour vasculature and enhances nanoparticle uptake...
April 30, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29702143/prolonging-pulse-duration-in-ultrasound-mediated-gene-delivery-lowers-acoustic-pressure-threshold-for-efficient-gene-transfer-to-cells-and-small-animals
#17
Dominic M Tran, James Harrang, Shuxian Song, Jeremy Chen, Bryn M Smith, Carol H Miao
While ultrasound-mediated gene delivery (UMGD) has been accomplished using high peak negative pressures (PNPs) of 2 MPa or above, emerging research showed that this may not be a requirement for microbubble (MB) cavitation. Thus, we investigated lower-pressure conditions close to the MB inertial cavitation threshold and focused towards further increasing gene transfer efficiency and reducing associated cell damage. We created a matrix of 21 conditions (n = 3/cond.) to test in HEK293T cells using pulse durations spanning 18 μs-36 ms and PNPs spanning 0...
April 24, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29702099/prostate-ablation-using-high-intensity-focused-ultrasound-the-potential-role-for-patient-preference-information-a-literature-review
#18
REVIEW
Olufemi Babalola, Joyce Ting-Hsuan Lee, Charles Viviano
PURPOSE: The Food and Drug Administration (FDA) recently allowed marketing of two HIFU devices for prostate tissue ablation indications after previous rejections for a prostate cancer indication due to insufficient data on clinical effectiveness or direct patient benefit. A review of the safety and effectiveness of HIFU and knowledge regarding patient preferences, such as tolerance for adverse events associated with HIFU ablation of tissue in men with prostate cancer, may inform decision-making for device developers and the FDA...
April 24, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29693936/cardiac-point-of-care-using-ultrasound
#19
Mitsuharu Kodaka
Patients with cardiac disease have high mortality rates, mainly owing to shock. Therefore, evaluation of cardiac function is one of the most challenging issues in the intensive and critical care unit. Cardiac point-of-care tests using ultrasound, such as focus assessed transthoracic echo (FATE) and rapid ultrasound in shock (RUSH). are useful for diagnosis and initial care of such patients. The author will introduce first a basic FATE protocol of how to scan from position 1-4, including subcostal 4-chamber, apical 4-chamber, parasternal long and short axis, and pleural scanning...
May 2017: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/29689636/clinical-usefulness-of-the-microbubble-contrast-agent-sonovue-in-enhancing-the-effects-of-high-intensity-focused-ultrasound-for-the-treatment-of-adenomyosis
#20
Wang Jingqi, Zhang Lu, Zhang Jun, Ma Yuhong, Yang Wei, Ran Lifeng, Jin Chengbing, Dimitrov Dimitrov Dobromir, Zhu Hui, Zhou Kun
OBJECTIVE: To evaluate the clinical usefulness of the microbubble contrast agent SonoVue in enhancing high-intensity focused ultrasound (HIFU) for the treatment of adenomyosis. METHODS: A total of 102 patients with adenomyosis, assessed from August 2015 to April 2017, were randomly divided into 1-minute (A) and 10-minute (B) groups, respectively. In groups A and B, HIFU started 1 minute and 10 minutes, respectively, after SonoVue injection. All patients underwent a magnetic resonance imaging scan before and after HIFU treatment...
April 24, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
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