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Amnon Amir, Daniel McDonald, Jose A Navas-Molina, Evguenia Kopylova, James T Morton, Zhenjiang Zech Xu, Eric P Kightley, Luke R Thompson, Embriette R Hyde, Antonio Gonzalez, Rob Knight
High-throughput sequencing of 16S ribosomal RNA gene amplicons has facilitated understanding of complex microbial communities, but the inherent noise in PCR and DNA sequencing limits differentiation of closely related bacteria. Although many scientific questions can be addressed with broad taxonomic profiles, clinical, food safety, and some ecological applications require higher specificity. Here we introduce a novel sub-operational-taxonomic-unit (sOTU) approach, Deblur, that uses error profiles to obtain putative error-free sequences from Illumina MiSeq and HiSeq sequencing platforms...
March 2017: MSystems
James T Morton, Jon Sanders, Robert A Quinn, Daniel McDonald, Antonio Gonzalez, Yoshiki Vázquez-Baeza, Jose A Navas-Molina, Se Jin Song, Jessica L Metcalf, Embriette R Hyde, Manuel Lladser, Pieter C Dorrestein, Rob Knight
Advances in sequencing technologies have enabled novel insights into microbial niche differentiation, from analyzing environmental samples to understanding human diseases and informing dietary studies. However, identifying the microbial taxa that differentiate these samples can be challenging. These issues stem from the compositional nature of 16S rRNA gene data (or, more generally, taxon or functional gene data); the changes in the relative abundance of one taxon influence the apparent abundances of the others...
January 2017: MSystems
Brian C Gulack, Ehsan Benrashid, Robert D B Jaquiss, Andrew J Lodge
BACKGROUND: Outcomes after surgical pulmonary valve replacement (PVR) in patients with congenital cardiac disease are limited by long-term valve deterioration, which may be hastened by turbulent flow. The use of the Trifecta valve (St. Jude Medical, Little Canada, MN) at our institution (Duke University Medical Center, Durham, NC) appears to result in low postimplantation transvalvular gradients. This study was performed to compare the early transvalvular gradient associated with the Trifecta valve with that associated with two other valves commonly used for PVR...
February 2017: Annals of Thoracic Surgery
Roberto Adriano Latini, Luca Testa, Nedy Brambilla, Maurizio Tusa, Francesco Bedogni
In the last years, a general shift toward the use of surgical bioprosthetic aortic valves rather than mechanical valves with subsequent less use of anticoagulant therapy has been observed. However, bioprosthetic valves have limited durability. Reoperation, the current standard of care for these patients, carries a high surgical risk, especially because patients are elderly and with numerous comorbidities. Recently, transcatheter aortic valve replacement within a failed bioprosthetic valve (valve-in-valve procedure) has proven feasible...
April 2016: Giornale Italiano di Cardiologia
Raul A Borracci, Miguel Rubio, Maria L Sestito, Carlos A Ingino, Carlos Barrero, Carlos A Rapallo
BACKGROUND: The aim was to assess the incidence of prosthesis-patient mismatch (PPM) after mitral valve replacement (MVR) in patients receiving Biocor® porcine or mechanical valves, and to evaluate the effect of PPM on long-term survival. METHODS: All patients undergoing MVR between 2009 and 2013 received either mechanical or bioprosthetic valves (Biocor® porcine). PPM was defined as severe when the indexed effective ori-fice area was < 0.9 cm2/m2, moderate between 0...
2016: Cardiology Journal
Zeeshan Sheikh Sheikh, Khan Usmanghani, Halima Nazar, Allah Nawaz, Lala Rukh Jahanzeb, Irshad Ahmad
Hypercholestriolemia is major risk factor that enhances the incidence of cardiovascular disease and coronary artery disease. The present study was conducted to normalize the lipid profile in the blood by using Biocor Plus for hypercholesterolemia compared with Simvastatin. It was prospective randomized case control study conducted on 70 diagnosed patients of hypercholesterolemia at Sohail Memorial Hospital, Karachi and Amir Habib Medical Center and Maternity Home, Karachi. Patients of both genders (30-70 years) with clinical diagnosis of Hypercholesterolemia...
November 2015: Pakistan Journal of Pharmaceutical Sciences
Ralf Guenzinger, Kathrin Fiegl, Michael Wottke, Ruediger S Lange
BACKGROUND: The aim of this study was to evaluate the long-term performance of the St. Jude Medical Biocor porcine stented bioprosthesis in the aortic position. METHODS: From January 1985 to December 1996, 455 patients underwent aortic valve replacement with the St. Jude Medical Biocor prosthesis at the German Heart Center Munich. Mean age at time of operation was 72.5 ± 9 years. In all, 172 patients (37.8%) underwent concomitant coronary artery bypass grafting and 20 patients (4...
December 2015: Annals of Thoracic Surgery
Sara E Brownell, Scott Freeman, Mary Pat Wenderoth, Alison J Crowe
Vision and Change in Undergraduate Biology Education outlined five core concepts intended to guide undergraduate biology education: 1) evolution; 2) structure and function; 3) information flow, exchange, and storage; 4) pathways and transformations of energy and matter; and 5) systems. We have taken these general recommendations and created a Vision and Change BioCore Guide-a set of general principles and specific statements that expand upon the core concepts, creating a framework that biology departments can use to align with the goals of Vision and Change...
2014: CBE Life Sciences Education
Augusto D'Onofrio, Fabio Zucchetta, Gino Gerosa
Transcatheter "Valve-in-Valve" implantation (ViV) has shown promising results in high-risk patients suffering from structural valve deterioration (SVD) of a previously implanted heart valve bioprosthesis. We present a case of a 68-year-old woman with a history of three previous cardiac operations on the aortic and mitral valve. At the time of admission she was severely symptomatic due to a simultaneous SVD of a 23 mm aortic and of a 29 mm mitral St. Jude Biocor bioprosthesis. Because of the history of several cardiac operations and to her comorbidities, the patient was considered with an extremely high surgical risk profile and was therefore scheduled for double concomitant mitral and aortic ViV...
September 1, 2014: Catheterization and Cardiovascular Interventions
Fabrizio Sansone, Guglielmo Mario Actis Dato, Edoardo Zingarelli, Emanuele Ferrero, Sara Prot, Fabrizio Ceresa, Francesco Patanè, Riccardo Casabona
BACKGROUND: Stentless prostheses have an interesting hemodynamic performance when compared to stented prostheses and are recommended in cases of small aortic annulus. MATERIALS AND METHODS: From January 1996 to January 2004, 138 patients suffering from aortic disease, underwent aortic valve replacement. • Group A: 93 patients underwent stentless aortic valve implantation [stentless Biocor (Biocor Industria e Pesguisa Ltda, Belo Horizonte, Brazil) and stentless Sorin (Sorin Group, Saluggia, Italy)]...
May 2014: Journal of Cardiology
Marisa Cevasco, Stephanie L Mick, Michael Kwon, Lawrence S Lee, Edward P Chen, Frederick Y Chen
BACKGROUND AND AIM OF THE STUDY: Currently, there is no universal standard for sizing bioprosthetic aortic valves. Hence, a standardized comparison was performed to clarify this issue. METHODS: Every size of four commercially available bioprosthetic aortic valves marketed in the United States (Biocor Supra; Mosaic Ultra; Magna Ease; Mitroflow) was obtained. Subsequently, custom sizers were created that were accurate to 0.0025 mm to represent aortic roots 18 mm through 32 mm, and these were used to measure the external diameter of each valve...
May 2013: Journal of Heart Valve Disease
Ana Carolina Tieppo Fornari, Luís Henrique Tieppo Fornari, Juan Victor Piccoli Soto Paiva, Pauline Elias Josende, João Ricardo Michelin Sant'anna, Paulo Roberto Prates, Renato A K Kalil, Ivo A Nesralla
OBJECTIVE: Study designed to identify characteristics of patients related to increased hospital mortality after valve replacement, assumed as risk factors. METHODS: Retrospective study including 808 patients submitted to the implant of St. Jude Biocor porcine bioprosthesis between 1994 and 2009 at Instituto de Cardiologia do Rio Grande do Sul. Primary outcome was hospital death and hospital mortality was related to demographic and surgical characteristics. Statistics include t-test, qui-square test and logistical regression analysis...
December 2012: Revista Brasileira de Cirurgia Cardiovascular
Tomaso Bottio, Edward Buratto, Carlo Dal Lin, Alban Lika, Vincenzo Tarzia, Giulio Rizzoli, Gino Gerosa
BACKGROUND AND AIM OF THE STUDY: The study aim was to compare the hydrodynamics of the Carpentier-Edwards Magna 21 (CEM) and St. Jude Medical Biocor-Epic-Supra 21 (SJME) valves at increasing stroke volume and pulse rate in two different aortic conduits, namely straight and with sinuses of Valsalva present. METHODS: Both valve types were tested in the aortic chamber of the Sheffield pulse duplicator, at rates of 70, 80 and 90 beats/min, and stroke volumes of 50 and 60 ml...
November 2012: Journal of Heart Valve Disease
Alessandra Giuliani, Adrian Manescu, Emanuel Larsson, Giuliana Tromba, Giuseppe Luongo, Adriano Piattelli, Francesco Mangano, Giovanna Iezzi, Carlo Mangano
BACKGROUND: In recent years, there has been interest on the fabrication of systems using particulates or block-based approach for bone tissue engineering (TE) scaffolds, possessing porous interconnected structures. In fact, these particular morphologies greatly increase the surface area for more chemical and biological reactions to take place. PURPOSE: This study was designed to demonstrate the unique capability of the synchrotron radiation x-ray microtomography (micro-CT) in offering an advanced characterization of coralline-derived (Biocoral) biomaterials placed in human maxillary defects as it allows, in a nondestructive way, a complete, precise, and high-resolution three-dimensional analysis of their microstructural parameters...
October 2014: Clinical Implant Dentistry and related Research
Jarmo M Gunn, Jami Rekola, Jussi Hirvonen, Allan J Aho
AIM: The aim of this study was to compare the osteoconductivity and suitability of three biomaterials used as particulate fillers; S53P4 bioactive glass, allogeneic fresh frozen bone and coral-derived calcium carbonate. MATERIALS AND METHODS: Materials were implanted into drill-holes in the femoral condyles of adult rabbits. Follow-ups were performed at 3, 6, 12 and 24 weeks. Host-response, osteoconductivity, bonding and filler-effect were evaluated by SEM, EDXA and histology and histomorphometry to evaluate...
September 2013: Acta Odontologica Scandinavica
WooSung Jang, Yong Jin Kim, Kwangho Choi, Hong-Gook Lim, Woong-Han Kim, Jeong Ryul Lee
OBJECTIVES: Pulmonary valve replacement (PVR) is performed to reduce right ventricular (RV) volume overload, resulting in improved ventricular function and clinical status. Significant pulmonary regurgitation (PR) after tetralogy of Fallot (TOF) repair could result in RV dysfunction, exercise intolerance, arrhythmia and sudden death. The present study was conducted to investigate the mid-term clinical outcomes of PVR after TOF repair. METHODS: Between 2001 and 2010, we retrospectively reviewed the outcomes of 131 (89 males and 42 females) PVRs with PR or pulmonary steno-insufficiency after TOF repair...
July 2012: European Journal of Cardio-thoracic Surgery
J Matthew Brennan, Karen P Alexander, Amelie Wallace, Audra B Hodges, John C Laschinger, Kent W Jones, Sean O'Brien, Laura E Webb, Rachel S Dokholyan, Eric D Peterson
BACKGROUND AND AIM OF THE STUDY: The American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend a three-month administration of warfarin following bioprosthetic valve replacement (BVR). However, strong evidence supporting this recommendation is lacking, making process variation likely. METHODS: In the ANSWER Registry, a total of 386 patients who had received either Epic or Biocor BVRs between May 2007 and August 2008 at 40 centers was enrolled...
January 2012: Journal of Heart Valve Disease
Sameh M Said, Elena Ashikhmina, Kevin L Greason, Rakesh M Suri, Soon J Park, Richard C Daly, Harold M Burkhart, Joseph A Dearani, Thoralf M Sundt, Hartzell V Schaff
BACKGROUND: Pericardial bioprostheses have favorable echocardiographic hemodynamics in the aortic position compared with porcine valves; however, there are few data comparing clinical outcomes. Our objective was to assess the late results of the two valve types. METHODS: We reviewed 2,979 patients aged 65 years or older undergoing aortic valve replacement with pericardial (n=1,976) or porcine (n=1,003) prostheses between January 1993 and December 2007. The most common pericardial prostheses were Carpentier-Edwards Perimount and Mitroflow, and the most common porcine valves were Medtronic Mosaic, Carpentier-Edwards, Hancock modified orifice, and St...
June 2012: Annals of Thoracic Surgery
Allison Hubel
Cell therapies are typically collected in one location, processed in a second location, and then administered in a third location. The ability to preserve the cells is critical to their clinical application. It improves patient access to therapies by increasing the genetic diversity of cells available. In addition, the ability to preserve cells improves the "manufacturability" of a cell therapy product by permitting the cells to be stored until the patient is ready for administration of the therapy, permitting inventory control of products, and improving management of staffing at cell therapy facilities...
November 2011: Transfusion
Morgan L Brown, Soon J Park, Thoralf M Sundt, Hartzell V Schaff
OBJECTIVE: Patients who require aortic valve replacement are increasingly receiving biologic valves to avoid long-term anticoagulation. The thromboembolic risk of bioprosthetic valves is reportedly low. The study objective was to review the incidence of early valve thrombosis requiring reoperation in patients who received a bioprosthetic valve in the aortic position. METHODS: We reviewed all adult patients who had a biologic valve implanted in the aortic position at Mayo Clinic between January 1993 and July 2009...
July 2012: Journal of Thoracic and Cardiovascular Surgery
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