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https://www.readbyqxmd.com/read/28071912/insights-into-catalytic-mechanism-of-unsaturated-glucuronyl-hydrolase-of-bacillus-sp-gl1
#1
Jing Xiong, Dingguo Xu
Together with polysaccharide lyases, the unsaturated glucuronyl hydrolase of Bacillus sp. GL1 are responsible for the metabolism of glycosaminoglycans, which exhibits important role in various crucial physiological events. More importantly, the degradation mechanism of glycosaminoglycans often causes extracellular bacterial infection, and is thought to be one of virulence factors. We have previously studied the first degradation step catalyzed by polysaccharide lyases. In this work, we then focused the degradation of the unsaturated chondroitin disaccharide, products of chondroitin lyases...
January 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28070706/analysis-of-12-x-str-loci-in-the-population-of-south-croatia
#2
Gordan Mršić, Petar Ozretić, Josip Crnjac, Siniša Merkaš, Ivana Račić, Sara Rožić, Viktorija Sukser, Maja Popović, Marina Korolija
The aim of the study was to assess forensic pertinence of 12 short tandem repeats (STRs) on X-chromosome in south Croatia population. Investigator(®) Argus X-12 kit was used to co-amplify 12 STR loci belonging to four linkage groups (LGs) on X-chromosome in 99 male and 98 female DNA samples of unrelated donors. PCR products were analyzed by capillary electrophoresis. Population genetic and forensic parameters were calculated by the Arlequin and POPTREE2 software, and an on-line tool available at ChrX-STR.org...
January 9, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28057991/extracorporeal-shockwave-lithotripsy-without-radiation-ultrasound-localization-is-as-effective-as-fluoroscopy
#3
Hazel Elizabeth Smith, David Alistair Bryant, Jenny KooNg, Richard Alexander Chapman, Gareth Lewis
CONTEXT: Extracorporeal shockwave lithotripsy (SWL) is the first-line treatment for renal calculi in most cases. Recent technology has allowed lithotriptor machines to localize stones using fluoroscopy or ultrasound (US). AIM: The aim of this study is to compare stone free rates (SFR) using two techniques. METHODS: This is a single center retrospective cohort study. We have studied 95 patients with renal calculi undergoing first SWL treatment with localization using US (48 pts) and fluoroscopy (47 pts)...
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28057518/structural-and-molecular-determinants-affecting-the-interaction-of-retinol-with-human-crbp1
#4
Ilaria Menozzi, Francesca Vallese, Eugenia Polverini, Claudia Folli, Rodolfo Berni, Giuseppe Zanotti
Four cellular retinol-binding protein (CRBP) types (CRBP1,2,3,4) are encoded in the human genome. Here, we report on X-ray analyses of human apo- and holo-CRBP1, showing nearly identical structures, at variance with the results of a recent study on the same proteins containing a His-Tag, which appears to be responsible for a destabilizing effect on the apoprotein. The analysis of crystallographic B-factors for our structures indicates that the putative portal region, in particular α-helix-II, along with Arg58 and the E-F loop, is the most flexible part of both apo- and holoprotein, consistent with its role in ligand uptake and release...
January 2, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28056709/deviation-analysis-for-c1-2-pedicle-screw-placement-using-a-three-dimensional-printed-drilling-guide
#5
Xinghuo Wu, Rong Liu, Jie Yu, Lin Lu, Cao Yang, Zengwu Shao, Zhewei Ye
Cervical transarticular fixation is a technically demanding procedure. This study aimed to develop a safer and more accurate method for C1/2 pedicle screw placement using a three-dimensional printed drilling guide. A total of 20 patients with C1/2 fractures and dislocations were recruited, and their computed tomography scans were evaluated. Under the assistance of the three-dimensional printed drilling guide, bilateral C1/2 pedicle screws were successfully placed in the three-dimensional C1/2 models. Then, sagittal and axial computed tomography scans were obtained, and the accuracy and safety of screw placement were evaluated based on X-Y-Z axis setup...
December 1, 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28054065/the-evaluation-of-5-amino-and-5-hydroxyuracil-derivatives-as-potential-quadruplex-forming-agents
#6
Gábor Paragi, Zoltán Kupihár, Gábor Endre, Célia Fonseca Guerra, Lajos Kovács
5-Substituted uracils (NH2 or OH groups in position 5) have been examined theoretically and experimentally as potential building blocks in quadruplex structures. Our high level Density Functional Theory (DFT) calculations showed that the tetramer formation and stacking energies for 5-substituted uracils are similar to the energies of purine-based xanthine (X) or guanine (G) structures. As tetrads of 5-substituted uracils cover almost exactly the same area as purine tetrads, mixed tetrads or quadruplex structures based on X or G and 5-substituted uracil motifs are possible...
January 5, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28053696/invasive-thymoma-with-pure-red-cell-aplasia-and-amegakaryocytic-thrombocytopenia
#7
Takuya Onuki, Yusuke Kiyoki, Sho Ueda, Masatoshi Yamaoka, Seiich Shimizu, Masaharu Inagaki
We here describe a case involving a 67-yearold female patient who was referred to our hospital due to severe anemia (hemoglobin, 5.0 g/dL), thrombocytopenia (platelet count, 0.6 × 10(4)/μL), and a mediastinal shadow with calcification noted on X-ray. On admission, an anterior mediastinal tumor was detected, and bone marrow biopsy revealed few megakaryocytes and severely reduced numbers of erythroid cells. The diagnosis was thymoma with pure red cell aplasia (PRCA) and acquired amegakaryocytic thrombocytopenia (AAMT)...
November 2, 2016: Hematology Reports
https://www.readbyqxmd.com/read/28052488/lymphatic-endothelial-cells-produce-m-csf-causing-massive-bone-loss-in-mice
#8
Wensheng Wang, Hua Wang, Xichao Zhou, Xing Li, Sun Wen, Michael Dellinger, Brendan F Boyce, Lianping Xing
Gorham-Stout disease (GSD) is a rare bone disorder characterized by aggressive osteolysis associated with lymphatic vessel invasion within bone marrow cavities. The etiology of GSD is not known and there is no effective therapy or animal model for the disease. Here, we investigated if lymphatic endothelial cells (LECs) affect osteoclasts (OCs) to cause a GSD osteolytic phenotype in mice. We examined the effect of a mouse LEC line on osteoclastogenesis in co-cultures. LECs significantly increased RANKL-mediated OC formation and bone resorption...
January 4, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28050432/epidermoid-cyst-of-the-sole-a-case-report
#9
Sathyakrishna Basavapatna Ramakrishnaiah, Santosh Singh Rajput, Nayar Sajeeth Gopinathan
Epidermoid cysts are common benign subcutaneous lesion also termed as epidermal cysts. Epidermoid cyst are commonly seen in hairy regions of body like scalp, face and scrotum, can be single or multiple, but rarely can occur in glabrous skin of palm and sole. They are known to result from progressive cystic ectasia of the infundibular portion of hair follicle but the pathogenesis in palmo-plantar epidermoid cyst differs that is traumatic sequestration of epidermal elements into dermis. Here, we report a case of 30-year-old female presented with complaints of swelling in her left sole...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28048722/mo-fg-campus-iep2-05-feasibility-demonstration-of-high-voltage-clinical-ct-and-impact-on-x-ray-penetration-through-metal-objects
#10
Y Jin, V Robinson, L Gjesteby, G Wang, J Verburg, D Giantsoudi, H Paganetti, B De Man
PURPOSE: To demonstrate the possibility and quantify the impact of operating a clinical CT scanner at exceptionally high x-ray tube voltage for better penetration through metal objects and facilitating metal artifact reduction. METHODS: We categorize metal objects according to the data corruption severeness (level of distortion and complete photon starvation fraction). To demonstrate feasibility and investigate the impact of high voltage scanning we modified a commercial GE LightSpeed VCT scanner (generator and software) to enable CT scans with x-ray tube voltages as high as 175 kVp...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047677/su-f-p-59-detection-of-missing-surgical-needles-with-intraoperative-mobile-x-ray
#11
L Chen, B Berger
PURPOSE: To determine the minimal detectable size of a surgical needle using intraoperative mobile x-ray imaging. Also, varying techniques such as low kVp and high tube current were tested to investigate whether this improved the detection of the various needle sizes. METHODS: Seven surgical needle sizes, 6.5, 8, 11, 13, 16, 17 and 19 mm, were positioned on three regions (thoracic, abdominal and pelvic) of an adult size anthropomorphic RANDO phantom. The phantom represents an average size adult...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046406/we-ab-bra-12-post-implant-dosimetry-in-prostate-brachytherapy-by-x-ray-and-mri-fusion
#12
S Park, Y Le, D Song, J Lee
PURPOSE: For post-implant dosimetric assessment after prostate brachytherapy, CT-MR fusion approach has been advocated due to the superior accuracy on both seeds localization and soft tissue delineation. However, CT deposits additional radiation to the patient, and seed identification in CT requires manual review and correction. In this study, we propose an accurate, low-dose, and cost-effective post-implant dosimetry approach based on X-ray and MRI. METHODS: Implanted seeds are reconstructed using only three X-ray fluoroscopy images by solving a combinatorial optimization problem...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046251/su-g-iep3-02-characteristics-of-in-vivo-mosfet-dosimeters-for-diagnostic-x-ray-low-dose-measurements
#13
S Li, S Ali, K Harper, Q Liang, D Serratore
PURPOSE: To correct in-vivo metal-oxide-semiconductor field-effect transistor (MOSFET) dosimeters dependence on X-ray energy, dose and dose rate, and temperature in order to measure doses or exposures on several anatomic points of interest undergoing some routine radiographs. METHODS: A mobile MOSFET system (BEST Medical) was carefully calibrated with X-ray at kVp of 70, 80, 100, 120, and 138 kVp, phantom temperatures at 0, 21, and 43 oC, and exposure range from 0...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032699/an-analysis-of-paravertebral-ossification-in-cervical-artificial-disc-replacement-a-novel-classification-based-on-computed-tomography
#14
Wei Tian, Ming-Xing Fan, Ya-Jun Liu, Xiao Han, Kai Yan, Han Wang, Yan-Wei Lyu
OBJECTIVE: Cervical artificial disc replacement (CADR) is a new technology in cervical spine surgery. However, CADR may result in paravertebral ossification (PO) after surgery and affect the mobility of the related spinal segments. The present widely used assessment method based on X-ray tomography cannot provide the position information of PO, and also PO detection rates by X-ray are low. The incidence of PO varies dramatically between studies. This study built a novel classification system based on cervical computer tomography (CT) scan to re-evaluate the incidence of PO and its influence on CADR, and also analyzed the predisposing factors of PO...
November 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28005238/comparison-between-x-rays-spectra-and-their-effective-energies-in-small-animal-ct-tomographic-imaging-and-dosimetry
#15
Mahdjoub Hamdi, Malika Mimi, M'hamed Bentourkia
Small animal CT imaging and dosimetry usually rely on X-ray radiation produced by X-ray tubes. These X-rays typically cover a large energy range. In this study, we compared poly-energetic X-ray spectra against estimated equivalent (effective) mono-energetic beams with the same number of simulated photons for small animal CT imaging and dosimetry applications. Two poly-energetic X-ray spectra were generated from a tungsten anode at 50 and 120 kVp. The corresponding effective mono-energetic beams were established as 36 keV for the 50 kVp spectrum and 49...
December 22, 2016: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/27995257/supramolecular-organization-of-perfluorinated-1h-indazoles-in-the-solid-state-using-x-ray-crystallography-ssnmr-and-sensitive-vcd-and-non-sensitive-mir-fir-and-raman-to-chirality-vibrational-spectroscopies
#16
María M Quesada-Moreno, Juan Ramón Avilés-Moreno, Juan Jesús López-González, Kane Jacob, Laure Vendier, Michel Etienne, Ibon Alkorta, José Elguero, Rosa M Claramunt
1H-Indazole derivatives exhibit a remarkable property since some of them form chiral supramolecular structures starting from achiral monomers. The present work deals with the study of three perfluorinated 1H-indazoles that resolve spontaneously as conglomerates. These conglomerates can contain either a pure enantiomer (one helix) or a mixture of both enantiomers (both helices) with an enantiomeric excess (e.e.) of one of them. The difficulty of the structural analysis of these types of compounds is thus clear...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27994122/cranial-shape-evolution-in-adaptive-radiations-of-birds-comparative-morphometrics-of-darwin-s-finches-and-hawaiian-honeycreepers
#17
Masayoshi Tokita, Wataru Yano, Helen F James, Arhat Abzhanov
Adaptive radiation is the rapid evolution of morphologically and ecologically diverse species from a single ancestor. The two classic examples of adaptive radiation are Darwin's finches and the Hawaiian honeycreepers, which evolved remarkable levels of adaptive cranial morphological variation. To gain new insights into the nature of their diversification, we performed comparative three-dimensional geometric morphometric analyses based on X-ray microcomputed tomography (µCT) scanning of dried cranial skeletons...
February 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27984864/electric-potential-invariants-and-ions-in-molecules-effective-potentials-for-molecular-rydberg-states
#18
Stephen L Coy, David D Grimes, Yan Zhou, Robert W Field, Bryan M Wong
The dependence of multipole moments and polarizabilities on external fields appears in many applications including biomolecular molecular mechanics, optical non-linearity, nanomaterial calculations, and the perturbation of spectroscopic signatures in atomic clocks. Over a wide range of distances, distributed multipole and polarizability potentials can be applied to obtain the variation of atom-centered atoms-in-molecules electric properties like bonding-quenched polarizability. For cylindrically symmetric charge distributions, we examine single-center and atom-centered effective polarization potentials in a non-relativistic approximation for Rydberg states...
December 21, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27967083/time-dependent-probability-density-function-in-cubic-stochastic-processes
#19
Eun-Jin Kim, Rainer Hollerbach
We report time-dependent probability density functions (PDFs) for a nonlinear stochastic process with a cubic force using analytical and computational studies. Analytically, a transition probability is formulated by using a path integral and is computed by the saddle-point solution (instanton method) and a new nonlinear transformation of time. The predicted PDF p(x,t) in general involves a time integral, and useful PDFs with explicit dependence on x and t are presented in certain limits (e.g., in the short and long time limits)...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27967059/influence-of-xe-and-kr-impurities-on-x-ray-yield-from-debris-free-plasma-x-ray-sources-with-an-ar-supersonic-gas-jet-irradiated-by-femtosecond-near-infrared-wavelength-laser-pulses
#20
V L Kantsyrev, K A Schultz, V V Shlyaptseva, G M Petrov, A S Safronova, E E Petkov, J J Moschella, I Shrestha, W Cline, P Wiewior, O Chalyy
Many aspects of physical phenomena occurring when an intense laser pulse with subpicosecond duration and an intensity of 10^{18}-10^{19}W/cm^{2} heats an underdense plasma in a supersonic clustered gas jet are studied to determine the relative contribution of thermal and nonthermal processes to soft- and hard-x-ray emission from debris-free plasmas. Experiments were performed at the University of Nevada, Reno (UNR) Leopard laser operated with a 15-J, 350-fs pulse and different pulse contrasts (10^{7} or 10^{5})...
November 2016: Physical Review. E
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