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https://www.readbyqxmd.com/read/28537728/antimalarial-inhibitors-targeting-serine-hydroxymethyltransferase-shmt-with-in-vivo-efficacy-and-analysis-of-their-binding-mode-based-on-x-ray-cocrystal-structures
#1
Geoffrey Schwertz, Matthias C Witschel, Matthias Rottmann, Roger Bonnert, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A Aponte, Susan A Charman, Karen L White, Abhijit Kundu, Surajit Sadhukhan, Mel Lloyd, Gail M Freiberg, Myron Srikumaran, Marc Siggel, Adrian Zwyssig, Pimchai Chaiyen, François Diederich
Target-based approaches towards new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates for in vivo efficacy evaluation. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target assays and PfNF54 strains in cell-based assays with values in the low nanomolar range (3...
May 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28533481/massively-parallel-sequencing-and-genome-wide-copy-number-analysis-revealed-a-clonal-relationship-in-benign-metastasizing-leiomyoma
#2
Ren-Chin Wu, An-Shine Chao, Li-Yu Lee, Gigin Lin, Shu-Jen Chen, Yen-Jung Lu, Huei-Jean Huang, Chi-Feng Yen, Chien Min Han, Yun-Shien Lee, Tzu-Hao Wang, Angel Chao
Benign metastasizing leiomyoma (BML) is a rare disease entity typically presenting as multiple extrauterine leiomyomas associated with a uterine leiomyoma. It has been hypothesized that the extrauterine leiomyomata represent distant metastasis of the uterine leiomyoma. To date, the only molecular evidence supporting this hypothesis was derived from clonality analyses based on X-chromosome inactivation assays. Here, we sought to address this issue by examining paired specimens of synchronous pulmonary and uterine leiomyomata from three patients using targeted massively parallel sequencing and molecular inversion probe array analysis for detecting somatic mutations and copy number aberrations...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28529197/applications-of-nmr-to-membrane-proteins
#3
Stanley J Opella, Francesca M Marassi
Membrane proteins present a challenge for structural biology. In this article, we review some of the recent developments that advance the application of NMR to membrane proteins, with emphasis on structural studies in detergent-free, lipid bilayer samples that resemble the native environment. NMR spectroscopy is not only ideally suited for structure determination of membrane proteins in hydrated lipid bilayer membranes, but also highly complementary to the other principal techniques based on X-ray and electron diffraction...
May 18, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28525798/gasoline-sensor-based-on-piezoelectric-lateral-electric-field-excited-resonator
#4
B D Zaitsev, A A Teplykh, I A Borodina, I E Kuznetsova, E Verona
It has been shown that by using piezoelectric lateral electric field excited resonators based on X - cut LiNbO3, one can determine the octane number of gasoline. The measured dependence of gasoline permittivity on its octane number has shown that there is an ambiguous connection between pointed parameters. We have demonstrated both theoretically and experimentally that the value of the real part of the electrical impedance on the frequency of parallel resonance uniquely associates with the octane number of gasoline contacting the free side of the resonator...
May 4, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28506843/longitudinal-association-between-foot-and-ankle-symptoms-and-worsening-of-symptomatic-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#5
Kade L Paterson, Jessica Kasza, David J Hunter, Rana S Hinman, Hylton B Menz, George Peat, Kim L Bennell
OBJECTIVE: To assess whether foot and/or ankle symptoms are associated with an increased risk of worsening of knee pain and radiographic change in people with knee osteoarthritis (OA). METHODS: The presence and laterality of foot/ankle symptoms were recorded at baseline in 1368 participants from the Osteoarthritis Initiative with symptomatic radiographic knee OA. Knee pain severity (measured using the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale) and minimum medial tibiofemoral joint space (minJSW) width measured on x-ray were assessed yearly over the subsequent four years...
May 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28499349/epimetheus-a-multi-profile-normalizer-for-epigenomic-sequencing-data
#6
Mohamed-Ashick M Saleem, Marco-Antonio Mendoza-Parra, Pierre-Etienne Cholley, Matthias Blum, Hinrich Gronemeyer
BACKGROUND: Exponentially increasing numbers of NGS-based epigenomic datasets in public repositories like GEO constitute an enormous source of information that is invaluable for integrative and comparative studies of gene regulatory mechanisms. One of today's challenges for such studies is to identify functionally informative local and global patterns of chromatin states in order to describe the regulatory impact of the epigenome in normal cell physiology and in case of pathological aberrations...
May 12, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28498502/real-time-three-dimensional-jaw-tracking-in-temporomandibular-disorders
#7
Danilo Vieira da Cunha, Viviane Veroni Degan, Mário Vedovello Filho, Douglas Peres Bellomo, Marlete Ribeiro Silva, Daniel Antônio Furtado, Adriano Oliveira Andrade, Selma Terezinha Milagre, Adriano Alves Pereira
When a dysfunction occurs in any component of the stomatognathic system, temporomandibular disorders (TMD) may originates. The aim of this study was to compare the deviations, displacement, and the execution speed of mandibular movements among asymptomatic participants and those with TMD. Convenience sampling was used; forty participants diagnosed by clinical evaluation following the Research Diagnostic Criteria for Temporomandibular Disorders were divided into three groups: Arthropathy (GART, 10 participants, 40% men), Myopathy (GMYO, 10 participants, 30% men), and the Control Group (CG, 20 asymptomatic-participants, 25% men)...
May 12, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28498293/what-is-the-actual-3d-representation-of-the-rib-vertebra-angle-difference-mehta-s-angle
#8
Rob C Brink, Tom P C Schlösser, Marijn van Stralen, Koen L Vincken, Moyo C Kruyt, Winnie C W Chu, Jack C Y Cheng, René M Castelein
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To establish the relevance of the conventional two-dimensional (2D) RVAD and the relationship with the complex three-dimensional (3D) apical morphology in scoliosis. SUMMARY OF BACKGROUND DATA: The rib vertebra angle difference (RVAD, also known as Mehta's angle) describes apical rib asymmetry on conventional radiographs and was introduced as a prognostic factor for curve severity in early onset scoliosis, and later applied to other types of scoliosis as well...
May 11, 2017: Spine
https://www.readbyqxmd.com/read/28496081/-salvage-surgery-following-chemoradiotherapy-for-thymic-basaloid-cell-carcinoma
#9
Takashi Inoue, Yoshiyuki Ito, Morimichi Nishihira, Osamu Araki, Yoko Karube, Sumiko Maeda, Satoru Kobayashi, Noriyuki Ikeda, Hiromichi Inoue, Motohiko Tamura, Yuji Matsumura, Masayuki Chida
We performed salvage surgery after chemoradiotherapy(CRT) in a patient with thymic basaloid cell carcinoma. A 46-year-old man with an abnormal chest shadow on X-ray findings was referred to our hospital. Computed tomography revealed a partially solid tumor along with a multilocular cyst in the anterior mediastinum with mediastinal lymph node swelling infiltrating to the superior vena cava(SVC). Positron emission tomography revealed FDG accumulation (SUVmax 7.94)in the tumor. Pathological findings of a tumor biopsy specimen obtained by thoracoscopy led to a diagnosis of thymic basaloid cell carcinoma...
May 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28491099/induction-of-pluripotent-stem-cells-from-a-manifesting-carrier-of-duchenne-muscular-dystrophy-and-characterization-of-their-x-inactivation-status
#10
Yuko Miyagoe-Suzuki, Takashi Nishiyama, Miho Nakamura, Asako Narita, Fusako Takemura, Satoru Masuda, Narihiro Minami, Kumiko Murayama, Hirofumi Komaki, Yu-Ichi Goto, Shin'ichi Takeda
Three to eight percent of female carriers of Duchenne muscular dystrophy (DMD) develop dystrophic symptoms ranging from mild muscle weakness to a rapidly progressive DMD-like muscular dystrophy due to skewed inactivation of X chromosomes during early development. Here, we generated human induced pluripotent stem cells (hiPSCs) from a manifesting female carrier using retroviral or Sendai viral (SeV) vectors and determined their X-inactivation status. Although manifesting carrier-derived iPS cells showed normal expression of human embryonic stem cell markers and formed well-differentiated teratomas in vivo, many hiPS clones showed bi-allelic expression of the androgen receptor (AR) gene and loss of X-inactivation-specific transcript and trimethyl-histone H3 (Lys27) signals on X chromosomes, suggesting that both X chromosomes of the hiPS cells are in an active state...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28484993/hip-fracture-pattern-at-a-major-tanzanian-referral-hospital-focus-on-fragility-hip-fractures
#11
Munyaradzi Tsabasvi, Sonya Davey, Rogers Temu
This study examined hip fractures during a 5-year period at Kilimanjaro Christian Medical Center (KCMC). There was a general increase in proportions of fragility hip fractures during this period. PURPOSE: Fragility hip fractures are expected to increase in low-resource countries. This study examined hip fractures in the osteoporotic age group during a 5-year period at the Kilimanjaro Christian Medical Center (KCMC), which is located in Moshi, Tanzania. METHODS: We conducted a retrospective study of all hip fracture patients above the age of 50 who were admitted to KCMC between January 1, 2011 and December 31, 2015...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28480842/dinamics-of-knee-joint-space-asymmetry-on-x-ray-as-a-marker-of-knee-osteoarthritis-rehabilitation-efficacy
#12
N Sheveleva, L Minbayeva, Y Belyayeva
Reducing of articular cartilage functional volume in knee joint osteoarthritis occurs unevenly and accompanied with pathological changes of lower limb axis as a result of connective tissue and muscle structures dysfunction. Evaluation of X-ray knee joint space asymmetry seems to be informative to analyze the dynamics of lower extremities biomechanical imbalances characteristic for knee joint osteoarthritis. However, standardized method of X-ray joint space determining does not include its symmetry calculation...
March 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28475296/halogen-bonds-in-novel-polyhalogen-monoanions
#13
Yirong Mo, Changwei Wang, David Danovich, Sason Shaik
Polyhalogen monoanions [X2n+1]- (X=Cl and Br; n=1, 2, 3, 4 and 5) have been systematically studied using the block-localized wave function (BLW) method, which offers a valence bond (VB) analysis. For each species, the most stable isomer can be described as a central halide anion X- non-classically bonded to a number of dihalogen molecules X2 via "halogen bonds". VB analyses confirm the dominant role of the charge transfer interaction between the lone pair on X-and the  anti-bonding orbital of X2 molecule (n→σ*) in X3- and higher analogues...
May 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28467639/photocatalytic-co2-reduction-by-periodic-mesoporous-organosilica-pmo-containing-two-different-ruthenium-complexes-as-photosensitizing-and-catalytic-sites
#14
Yusuke Kuramochi, Masato Sekine, Kyohei Kitamura, Yoshifumi Maegawa, Yasutomo Goto, Soichi Shirai, Shinji Inagaki, Hitoshi Ishida
A periodic mesoporous organosilica (PMO) containing 2,2'-bipyridine (bpy) ligands within the framework (BPy-PMO) has a great potential for designing novel catalysts by modifying metal complexes. A photosensitizing site (Ru(PS)) was introduced by reacting cis-[Ru(bpy)2(dimethylsulfoxide)Cl]Cl with BPy-PMO. Then a catalytic site (Ru(Cat)) was brought in Ru(PS)x-BPy-PMO by reaction with a ruthenium polymer [Ru(CO)2Cl2]n. The stepwise modification of BPy-PMO successfully affords a novel photocatalyst Ru(PS)x-Ru(Cat)y-BPy-PMO...
May 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28463014/tests-of-simple-slopes-in-multiple-regression-models-with-an-interaction-comparison-of-four-approaches
#15
Yu Liu, Stephen G West, Roy Levy, Leona S Aiken
In multiple regression researchers often follow up significant tests of the interaction between continuous predictors X and Z with tests of the simple slope of Y on X at different sample-estimated values of the moderator Z (e.g., ±1 SD from the mean of Z). We show analytically that when X and Z are randomly sampled from the population, the variance expression of the simple slope at sample-estimated values of Z differs from the traditional variance expression obtained when the values of X and Z are fixed. A simulation study using randomly sampled predictors compared four approaches: (a) the Aiken and West ( 1991 ) test of simple slopes at fixed population values of Z, (b) the Aiken and West test at sample-estimated values of Z, (c) a 95% percentile bootstrap confidence interval approach, and (d) a fully Bayesian approach with diffuse priors...
May 2, 2017: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/28453516/on-a-fractional-order-calculus-model-in-diffusion-weighted-breast-imaging-to-differentiate-between-malignant-and-benign-breast-lesions-detected-on-x-ray-screening-mammography
#16
Sebastian Bickelhaupt, Franziska Steudle, Daniel Paech, Anna Mlynarska, Tristan Anselm Kuder, Wolfgang Lederer, Heidi Daniel, Martin Freitag, Stefan Delorme, Heinz-Peter Schlemmer, Frederik Bernd Laun
OBJECTIVE: To evaluate a fractional order calculus (FROC) model in diffusion weighted imaging to differentiate between malignant and benign breast lesions in breast cancer screening work-up using recently introduced parameters (βFROC, DFROC and μFROC). MATERIALS AND METHODS: This retrospective analysis within a prospective IRB-approved study included 51 participants (mean 58.4 years) after written informed consent. All patients had suspicious screening mammograms and indication for biopsy...
2017: PloS One
https://www.readbyqxmd.com/read/28441246/x-ray-imaging-analysis-of-intrathecal-baclofen-pumps-for-pediatric-emergency-medicine
#17
Brianna Nicole Carr, Thomas Sernas, Catherine A Mazzola
Intrathecal baclofen therapy has become increasingly popular because of its effectiveness in treating spasticity in pediatric patients. The device implanted into each patient is structurally similar. However, x-ray imaging can give the appearance of missing or extraneous objects on or near the intrathecal baclofen device. The composition of the material used in making the catheters is transparent on x-ray images. In addition, the connection port between the pump and catheter resembles the shape of a needle...
April 24, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28439703/the-impact-of-direct-vertebral-rotation-dvr-on-radiographic-outcome-in-surgical-correction-of-idiopathic-scoliosis
#18
Wiktor Urbanski, Michal J Wolanczyk, Wojciech Jurasz, Miroslaw Kulej, Piotr Morasiewicz, Szymon Lukasz Dragan, Marek Sasiadek, Szymon Feliks Dragan
INTRODUCTION: Recent developments of spinal instruments allow to address nearly all components of idiopathic scoliosis. Direct vertebral rotation (DVR) maneuver was introduced to correct apical axial vertebral rotation. It is however still not well established how efficiently DVR affects results of scoliosis correction. The object of the study was to evaluate en bloc apical vertebral rotation (DVR) and its impact on coronal and sagittal correction of the spine in patients undergoing surgical scoliosis treatment...
April 24, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28437341/measurement-of-thoracic-inlet-alignment-on-mri-reliability-and-the-influence-of-body-position
#19
Jun Qiao, Feng Zhu, Zhen Liu, Leilei Xu, Zezhang Zhu, Bangping Qian, Xu Sun, Qing Jiang, Yong Qiu
STUDY DESIGN: A retrospective radiographic study. OBJECTIVE: To investigate the reliability of using magnetic resonance imaging (MRI) to measure thoracic outlet parameters and whether supine MRI could supersede upright x-ray in measuring these parameters. SUMMARY OF BACKGROUND DATA: On x-ray, overlapped soft and bony tissues make sternum contour invisible. Thus, measuring thoracic inlet (TI) alignment on x-ray may be inaccurate. MRI could clearly show anatomy around TI...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28435254/daphnia-magna-and-xenopus-laevis-as-in-vivo-models-to-probe-toxicity-and-uptake-of-quantum-dots-functionalized-with-gh625
#20
Emilia Galdiero, Annarita Falanga, Antonietta Siciliano, Valeria Maselli, Marco Guida, Rosa Carotenuto, Margherita Tussellino, Lucia Lombardi, Giovanna Benvenuto, Stefania Galdiero
The use of quantum dots (QDs) for nanomedicine is hampered by their potential toxicologic effects and difficulties with delivery into the cell interior. We accomplished an in vivo study exploiting Daphnia magna and Xenopus laevis to evaluate both toxicity and uptake of QDs coated with the membranotropic peptide gH625 derived from the glycoprotein H of herpes simplex virus and widely used for drug delivery studies. We evaluated and compared the effects of QDs and gH625-QDs on the survival, uptake, induction of several responsive pathways and genotoxicity in D...
2017: International Journal of Nanomedicine
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