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https://www.readbyqxmd.com/read/28650890/solitary-choroidal-metastasis-from-lung-adenocarcinoma-on-fdg-pet-ct
#1
Zu-Gui Li
Solitary choroidal metastasis as an initial presentation of lung cancer is rare. A 67-year-old woman who initially presented with a 3-month history of blurred vision in the right eye was suggestive of choroidal melanoma on MRI. Preoperatively, a pulmonary mass was found on x-ray. She was referred for an FDG PET/CT imaging, which revealed a choroidal lesion with minimal FDG uptake in right eye and increased FDG activity in the known lung mass. A pathological diagnosis of metastatic lung adenocarcinoma was made after enucleation of the right eyeball...
June 24, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28631980/orexin-research-patent-news-from-2016
#2
Christoph Boss, Catherine Roch
The orexin (hypocretin) system consists of two G-protein-coupled receptors, orexin 1 (Ox1) and orexin 2 (Ox2) and two endogenous peptidic ligands, orexin A (OxA) and orexin B (OxB). It is evolutionarily highly conserved. In the brain, it is involved in the promotion of wakefulness under motivational circumstances as well as in anxiety and addictive disorders. In addition, its activation via the Ox1 receptor triggers apoptosis in several cancer cell lines. Dual orexin receptor antagonists (DORAs) such as suvorexant are successfully used to treat primary insomnia...
June 20, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28630834/van-neck-odelberg-disease-a-rare-case-report
#3
Amit Prakash Chaudhari, Gautam Shah, Sameer Sanjeev Patil, Aashish Babanrao Ghodke, Sagar B Kelkar
INTRODUCTION: Pain in groin without any history of trauma or positive clinical findings of infection or stress fracture in ischiopubic ramus poses challenges in diagnosis of the condition in prepubertal age. "Osteochondrosis of ischiopubic synchondrosis (IPS)" also called as "Van Neck-Odelberg" disease. Left leg dominant patient presented with pain in groin and limping with left leg dominance. Differential diagnosis - such as stress fractures, osteomyelitis, tuberculosis, post-traumatic osteolysis, or any neoplasia - is need be ruled out to arrive at diagnosis...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28624557/arthroscopic-lateral-retinacular-release-medial-retinacular-plication-and-partial-medial-tibial-tubercle-transfer-for-recurrent-patellar-dislocation
#4
Song Chen, Yiqin Zhou, Qirong Qian, Yuli Wu, Peiliang Fu, Haishan Wu
OBJECTIVE: To assess the efficacy of a therapeutic protocol composed of arthroscopic lateral retinacular release, medial retinacular plication, and partial medial tibial tuberosity transfer for patients with recurrent patellar dislocation. METHOD: 71 patients, 11 males and 60 females and a total of 77 knees, with recurrent dislocation of the patella were enrolled between 1998 and 2012. The average age of the patients was 19.5 years and 67 of them had previous knee trauma history...
June 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28620992/detection-of-imprinting-effects-for-quantitative-traits-on-x-chromosome-using-nuclear-families-with-multiple-daughters
#5
Kexin Yu, Ji-Yuan Zhou, Wing Kam Fung
Genomic imprinting is an epigenetic phenomenon in which the expression of an allele copy depends on its parental origin. This mechanism has been found to play an important role in many complex diseases. Statistical tests for imprinting effects have been developed for more than 15 years, but they are only suitable for autosomes. It was not until recently that the parental-asymmetry test on the X chromosome (XPAT) was proposed to test for imprinting effects. However, this test can only be used for qualitative traits...
July 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/28601748/development-of-thoracic-injury-risk-functions-for-the-thor-atd
#6
Gerald S Poplin, Timothy L McMurry, Jason L Forman, Joseph Ash, Daniel P Parent, Matthew J Craig, Eric Song, Richard Kent, Greg Shaw, Jeff Crandall
The Test Device for Human Occupant Restraint (THOR) 50th percentile male anthropomorphic test device (ATD) aims to improve the ability to predict the risk of chest injury to restrained automobile occupants by measuring dynamic chest deflection at multiple locations. This research aimed to describe the methods for developing a thoracic injury risk function (IRF) using the multi-point chest deflection metrics from the 50th percentile male THOR Metric ATD with the SD-3 shoulder and associating to post-mortem human subjects (PMHS) outcomes that were matched on identical frontal and frontal-oblique impact sled testing conditions...
June 8, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28585175/nematicidal-effect-of-rhizobacteria-on-plant-parasitic-nematodes-associated-with-vineyards
#7
E Aballay, S Prodan, A Zamorano, C Castaneda-Alvarez
The action of metabolites and exoenzymes from rhizobacteria on different plant-parasitic nematodes has an influence on the nematicidal efficacy of the microbe. Seven rhizobacteria, divided into two bacterial groups, were evaluated in vitro for nematicidal activity on Meloidogyne ethiopica and Xiphinema index. The direct effect of their filtrates on egg hatching and juveniles of M. ethiopica as well as mobile stages of X. index was evaluated during a 72-h period. The production of four exoenzymes and two metabolites associated with nematode mortality was investigated...
July 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28581682/effect-of-cooling-rate-on-the-microstructure-and-luminescence-properties-of-sr2-mgsi2-o7-eu-2-dy-3-materials
#8
Ou Hai, Hongyi Jiang, Qiang Zhang, Qiang Ren, Xiulan Wu, Jieliang Hu
Sr2 MgSi2 O7 :Eu(2+) ,Dy(3+) long afterglow materials were prepared by a high-temperature solid-state reaction method with different cooling rates. The cooling rate had a slight effect on X-ray diffraction patterns and photoluminescence performance, but significantly modified the grain boundaries and long afterglow properties of the Sr2 MgSi2 O7 :Eu(2+) ,Dy(3+) materials. When the cooling rate was 1°C/min, grains remained intact with clear grain boundaries. As the cooling rate increased from 1°C/min to 5°C/min, some grain boundaries became indistinguishable...
June 5, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28576939/the-x-linked-intellectual-disability-protein-il1rapl1-regulates-dendrite-complexity
#9
Caterina Montani, Mariana Ramos-Brossier, Luisa Ponzoni, Laura Gritti, Andrzej W Cwetsch, Daniela Braida, Yoann Saillour, Benedetta Terragni, Massimo Mantegazza, Mariaelvina Sala, Chiara Verpelli, Pierre Billuart, Carlo Sala
Mutations and deletions of Interleukin-1 receptor accessory protein like 1 (IL1RAPL1) gene, localized on X chromosome, are associated to intellectual disability (ID) and autism spectrum disorder (ASD). IL1RAPL1 protein is localized at the postsynaptic compartment of excitatory synapses and plays a role in synapse formation and stabilization. Here we characterized the role of IL1RAPL1 in regulating dendrite morphology using primary neuronal cultures and Il1rapl1-KO mice. We identified, associated to hippocampal cognitive impairment, an increased number of dendrite branching points in CA1 and CA2 hippocampal neurons of Il1rapl1-KO mice...
June 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28572937/heat-penetration-attributes-of-milkfish-chanos-chanos-thermal-processed-in-flexible-pouches-a-comparative-study-between-steam-application-and-water-immersion
#10
Mary A Adepoju, Bamidele O Omitoyin, Chitradurga O Mohan, Aliyam A Zynudheen
The difference in the heating penetration characteristics of product processed in retort by steam-air application and water immersion was studied. Fresh milkfish (Chanos chanos) packed in dry pack and in oil medium, both in flexible pouches, was thermal processed to minimum F0 value of 7.77 at 121.1°C. Heat penetration values were recorded for each minute of processing with the aid Ellab (TM 9608, Denmark) temperature recorder. Retort come up time to achieve 121.1°C was observed to be less in steam-air which invariably led to a lower Ball's process time (B) and the total process time (T) observed in steam-air as compared to water immersion...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28570822/comment-on-x-ray-reflectivity-study-of-the-interaction-of-an-imidazolium-based-ionic-liquid-with-a-soft-supported-lipid-membrane
#11
Antonio Benedetto
No abstract text is available yet for this article.
June 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28567308/cut-off-value-of-medial-meniscal-extrusion-for-knee-pain
#12
Hiroaki Kijima, Naohisa Miyakoshi, Yuji Kasukawa, Yoshinori Ishikawa, Hayato Kinoshita, Kentaro Ohuchi, Masazumi Suzuki, Nozomi Kaga, Chie Sato, Shuichi Chida, Yoichi Shimada
Purpose. Medial meniscal extrusion (MME) has attracted attention as an index of knee pain in conjunction with clinical symptoms that could be more useful than the diagnosis of knee osteoarthritis on X-ray. However, the size of MME that would cause knee pain has not been clarified. The aim of the present study was to investigate the cut-off value of MME for knee pain. Methods. A total of 318 knees were evaluated. The presence of current or past knee pain was confirmed by interview. Next, MME was measured using vertical sonographic images of the medial joint spaces during weightbearing...
2017: Advances in Orthopedics
https://www.readbyqxmd.com/read/28555245/2d-4d-finger-length-ratio-and-skeletal-biomarker-of-biological-aging
#13
Leonid Kalichman, Valery Batsevich, Eugene Kobyliansky
The aim of this population-based study was to evaluate the association between the index to ring (2D:4D) finger length ratio and the osseographic score (OSS), the skeletal biomarker of biological aging. A sample included 802 males and 738 females who had participated in a Chuvashian skeletal aging study. Age, sex, basic demographics, anthropometric data and X-rays of both hands were collected. Each hand was visually classified on X-ray as either Type 1 - index finger was longer than ring finger; Type 2 - equal; or Type 3 - shorter than the ring finger...
May 30, 2017: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/28549550/forensic-efficiency-parameters-of-the-investigator-argus-x-12-kit-in-women-from-two-mestizo-and-seven-amerindian-populations-from-mexico
#14
I Cortés-Trujillo, B Ramos-González, O Salas-Salas, F Zuñiga-Chiquette, A Zetina Hernández, G Martínez-Cortés, M Ruiz-Hernández, A González-Martín, J F Ferragut, H Rangel-Villalobos
Allele frequency distribution and statistical parameters of forensic efficiency concerning the Investigator Argus X-12 kit (Qiagen, Hilden, Germany) were determined in a total sample of 641 unrelated Mexican females, including two Mestizo-admixed- populations (n=309) and seven Amerindian groups (n=332) from the main regions of the country. Most of the 12 X-STRs were in agreement with Hardy-Weinberg expectations in all nine Mexican populations. The power of discrimination in females (PD) and Median exclusion chance for trios (MECT) and duos (MECD) of this genetic system based on X-STRs were >99...
May 2017: Legal Medicine
https://www.readbyqxmd.com/read/28547574/effect-of-oxy133-an-osteogenic-oxysterol-on-new-bone-formation-in-rat-two-level-posterolateral-fusion-model
#15
Zorica Buser, Susan Drapeau, Frank Stappenbeck, Renata C Pereira, Farhad Parhami, Jeffrey C Wang
PURPOSE: The aim of our study was to determine the effect of Oxy133 and rhBMP2 on fusion rates and new bone formation in a rat posterolateral fusion (PLF) model. Furthermore, we examined whether Oxy133 could inhibit the adipogenesis that is often present in rhBMP2-induced fusions. METHODS: Sixty-four male Lewis rats underwent two levels PLF (L3-L5). All animals were randomly divided into eight groups based on the test compound that they received: control (DMSO), low-dose rhBMP2 (0...
May 25, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28537728/antimalarial-inhibitors-targeting-serine-hydroxymethyltransferase-shmt-with-in-vivo-efficacy-and-analysis-of-their-binding-mode-based-on-x-ray-cocrystal-structures
#16
Geoffrey Schwertz, Matthias C Witschel, Matthias Rottmann, Roger Bonnert, Ubolsree Leartsakulpanich, Penchit Chitnumsub, Aritsara Jaruwat, Wanwipa Ittarat, Anja Schäfer, Raphael A Aponte, Susan A Charman, Karen L White, Abhijit Kundu, Surajit Sadhukhan, Mel Lloyd, Gail M Freiberg, Myron Srikumaran, Marc Siggel, Adrian Zwyssig, Pimchai Chaiyen, François Diederich
Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine hydroxymethyltransferase (SHMT), designed to improve microsomal metabolic stability and to identify suitable candidates for in vivo efficacy evaluation. The best ligands inhibited Plasmodium falciparum (Pf) and Arabidopsis thaliana (At) SHMT in target assays and PfNF54 strains in cell-based assays with values in the low nanomolar range (3...
June 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28533481/massively-parallel-sequencing-and-genome-wide-copy-number-analysis-revealed-a-clonal-relationship-in-benign-metastasizing-leiomyoma
#17
Ren-Chin Wu, An-Shine Chao, Li-Yu Lee, Gigin Lin, Shu-Jen Chen, Yen-Jung Lu, Huei-Jean Huang, Chi-Feng Yen, Chien Min Han, Yun-Shien Lee, Tzu-Hao Wang, Angel Chao
Benign metastasizing leiomyoma (BML) is a rare disease entity typically presenting as multiple extrauterine leiomyomas associated with a uterine leiomyoma. It has been hypothesized that the extrauterine leiomyomata represent distant metastasis of the uterine leiomyoma. To date, the only molecular evidence supporting this hypothesis was derived from clonality analyses based on X-chromosome inactivation assays. Here, we sought to address this issue by examining paired specimens of synchronous pulmonary and uterine leiomyomata from three patients using targeted massively parallel sequencing and molecular inversion probe array analysis for detecting somatic mutations and copy number aberrations...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28529197/applications-of-nmr-to-membrane-proteins
#18
Stanley J Opella, Francesca M Marassi
Membrane proteins present a challenge for structural biology. In this article, we review some of the recent developments that advance the application of NMR to membrane proteins, with emphasis on structural studies in detergent-free, lipid bilayer samples that resemble the native environment. NMR spectroscopy is not only ideally suited for structure determination of membrane proteins in hydrated lipid bilayer membranes, but also highly complementary to the other principal techniques based on X-ray and electron diffraction...
May 18, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28525798/gasoline-sensor-based-on-piezoelectric-lateral-electric-field-excited-resonator
#19
B D Zaitsev, A A Teplykh, I A Borodina, I E Kuznetsova, E Verona
It has been shown that by using piezoelectric lateral electric field excited resonators based on X - cut LiNbO3, one can determine the octane number of gasoline. The measured dependence of gasoline permittivity on its octane number has shown that there is an ambiguous connection between pointed parameters. We have demonstrated both theoretically and experimentally that the value of the real part of the electrical impedance on the frequency of parallel resonance uniquely associates with the octane number of gasoline contacting the free side of the resonator...
September 2017: Ultrasonics
https://www.readbyqxmd.com/read/28506843/longitudinal-association-between-foot-and-ankle-symptoms-and-worsening-of-symptomatic-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#20
K L Paterson, J Kasza, D J Hunter, R S Hinman, H B Menz, G Peat, K L Bennell
OBJECTIVE: To assess whether foot and/or ankle symptoms are associated with an increased risk of worsening of knee pain and radiographic change in people with knee osteoarthritis (OA). METHODS: The presence and laterality of foot/ankle symptoms were recorded at baseline in 1368 participants from the Osteoarthritis Initiative (OAI) with symptomatic radiographic knee OA. Knee pain severity (measured using the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale) and minimum medial tibiofemoral joint space (minJSW) width measured on X-ray were assessed yearly over the subsequent 4 years...
May 13, 2017: Osteoarthritis and Cartilage
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