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https://www.readbyqxmd.com/read/29644570/psoriatic-disease-treatment-nowadays-unmet-needs-among-the-jungle-of-biologic-drugs-and-small-molecules
#1
EDITORIAL
Matteo Megna, Anna Balato, Maddalena Napolitano, Lucia Gallo, Francesco Caso, Luisa Costa, Nicola Balato, Raffaele Scarpa
No abstract text is available yet for this article.
April 11, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29597251/-appropriate-treatment-and-therapeutic-window-in-spasticity-treatment-with-incobotulinumtoxina-from-100-to-1000-units
#2
Giancarlo Ianieri, Riccardo Marvulli, Giulia Alessia Gallo, Pietro Fiore, Marisa Megna
Many neurological diseases (ischemic and hemorrhagic stroke, multiple sclerosis, infant cerebral palsy, spinal cord injuries, traumatic brain injury, and other cerebrovascular disorders) may cause muscle spasticity. Different therapeutic strategies have been proposed for the treatment of spasticity. One of the major treatments for tone modulation is botulinum toxin type A (BTX-A), performed in addition to other rehabilitation strategies based on individualized multidisciplinary programs aimed at achieving certain goals for each patient...
March 28, 2018: Toxins
https://www.readbyqxmd.com/read/29595115/efficacy-and-non-invasive-treatment-of-sialorrhea-in-the-goldenhar-syndrome
#3
R Marvulli, G A Gallo, L Mastromauro, P Fiore, G Ianieri, M Megna
Goldenhar syndrome (ocular-auricular-vertebral syndrome), a rare congenital condition arising from defects in the first and second brachial arches, consists in clinical variety of features ranging from facial abnormalities, ear-eye abnormalities, vertebral defects and congenital heart problems and severe obstructive sleep apnea. Due to craniofacial abnormalities, patients presents mechanical obstructive phenomena and sialorrhea that cause prone position, language's fastening, use of nasopharyngeal cannulas and tracheal intubation...
March 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29594970/lower-sustained-diphtheria-and-pertussis-antibody-concentrations-in-inflammatory-bowel-disease-patients
#4
Freddy Caldera, Sumona Saha, Arnold Wald, Christine A Garmoe, Sue McCrone, Bryant Megna, Dana Ley, Mark Reichelderfer, Mary S Hayney
BACKGROUND: Patients with inflammatory bowel disease (IBD) are often immunosuppressed, and those patients receiving anti-tumor necrosis factor α (TNF) therapy can have lower antibody responses to vaccines. Pertussis cases are at their highest levels in the post-vaccine era. There is little data regarding responses to the Tdap (tetanus, diphtheria, and acellular pertussis) vaccine in IBD patients. AIMS: The aim of this study was to compare sustained vaccine-induced Tdap antibody concentrations in a cohort of IBD patients stratified by medication regimens with healthy controls (HC) who had received an adult Tdap booster...
March 29, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29594327/coffee-consumption-metabolic-syndrome-and-clinical-severity-of-psoriasis-good-or-bad-stuff
#5
Luigi Barrea, Giovanna Muscogiuri, Carolina Di Somma, Giuseppe Annunziata, Matteo Megna, Andrea Falco, Anna Balato, Annamaria Colao, Silvia Savastano
Despite the wide consumption of coffee, its anti-inflammatory effect on clinical severity of psoriasis is still debatable. The aim of this study was to evaluate the association between the coffee consumption and clinical severity of psoriasis in a sample of patients stratified according to the presence of the metabolic syndrome (MetS) and smoking. This cross-sectional case-control observational study was conducted on 221 treatment-naïve psoriatic patients. Lifestyle habits, anthropometric measures, clinical and biochemical evaluations were obtained...
March 28, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29482382/guselkumab-for-the-treatment-of-psoriasis
#6
Matteo Megna, Anna Balato, Annunziata Raimondo, Nicola Balato
Psoriasis is a chronic immune mediated disease in which the interplay of T cells and keratinocytes seems to play a key role. In this context, the interleukin (IL)-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis and the selective inhibition of IL-23 may be viewed as an improvement of treatments blocking both IL-23 and IL-12, since its upstream actions. Areas covered: The authors performed a thorough and updated review on guselkumab, a fully human IgG1λ monoclonal antibody that blocks the p19 subunit of IL-23, analyzing efficacy and safety data from phase I, II and III trials...
April 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29426754/chronic-inducible-urticarias-in-children
#7
Maddalena Napolitano, Matteo Megna, Claudia Costa, Nicola Balato, Cataldo Patruno
No abstract text is available yet for this article.
February 6, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29368852/a-case-of-aquagenic-wrinkling-of-the-palms
#8
Marianna Donnarumma, Matteo Megna, Maddalena Napolitano, Cataldo Patruno
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29368849/pyoderma-gangrenosum-successfully-treated-with-topical-tacrolimus
#9
Maddalena Napolitano, Matteo Megna, Angela Patrì, Giuseppe Monfrecola, Nicola Balato
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29315640/virological-patterns-of-hcv-patients-with-failure-to-interferon-free-regimens
#10
Mario Starace, Carmine Minichini, Stefania De Pascalis, Margherita Macera, Laura Occhiello, Vincenzo Messina, Vincenzo Sangiovanni, Luigi E Adinolfi, Ernesto Claar, Davide Precone, Gianfranca Stornaiuolo, Maria Stanzione, Tiziana Ascione, Mara Caroprese, Rosa Zampino, Gianpaolo Parrilli, Ivan Gentile, Giuseppina Brancaccio, Vincenzo Iovinella, Salvatore Martini, Mario Masarone, Luca Fontanella, Addolorata Masiello, Evangelista Sagnelli, Rodolfo Punzi, Angelo Salomone Megna, Renato Santoro, Giovanni B Gaeta, Nicola Coppola
The study characterized the virological patterns and the resistance-associated substitutions (RASs) in patients with failure to IFN-free regimens enrolled in the real-life setting. All 87 consecutive HCV patients with failed IFN-free regimens, observed at the laboratory of the University of Campania, were enrolled. All patients had been treated with DAA regimens according to the HCV genotype, international guidelines, and local availability. Sanger sequencing of NS3, NS5A, and NS5B regions was performed at failure by home-made protocols...
May 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29023554/reproducibility-of-shear-wave-elastography-swe-in-patients-with-chronic-liver-disease
#11
Marcello Mancini, Angelo Salomone Megna, Monica Ragucci, Massimo De Luca, Giuseppina Marino Marsilia, Gerardo Nardone, Pietro Coccoli, Anna Prinster, Lorenzo Mannelli, Emilia Vergara, Serena Monti, Raffaele Liuzzi, Mariarosaria Incoronato
The presence of significant fibrosis is an indicator for liver disease staging and prognosis. The aim of the study was to determine reproducibility of real-time shear wave elastography using a hepatic biopsy as the reference standard to identify patients with chronic liver disease. Forty patients with chronic liver disease and 12 normal subjects received shear wave elastography performed by skilled operators. Interoperator reproducibility was studied in 29 patients. Fibrosis was evaluated using the Metavir score...
2017: PloS One
https://www.readbyqxmd.com/read/28994145/adherence-to-barcelona-clinic-liver-cancer-guidelines-in-field-practice-results-of-progetto-epatocarcinoma-campania
#12
Maria Guarino, Raffaella Tortora, Giorgio de Stefano, Carmine Coppola, Filomena Morisco, Angelo Salomone Megna, Francesco Izzo, Gerardo Nardone, Guido Piai, Luigi Elio Adinolfi, Giuseppe D'Adamo, Giovanni Battista Gaeta, Vincenzo Messina, Giampiero Francica, Vincenzo De Girolamo, Nicola Coppola, Marcello Persico, Giovan Giuseppe Di Costanzo
BACKGROUND: The BCLC algorithm is the standard system for clinical management of HCC. Data on adherence to this therapeutic paradigm are scarce. AIMS: This field-practice study aimed to provide a description of HCC cirrhotic patients in Southern Italy, to evaluate the adherence to BCLC guidelines and its impact on patients' survival. METHODS: We analyzed the region-wide Italian database of Progetto Epatocarcinoma Campania, which includes data of HCC cirrhotic patients, prospectively collected from January 2013 to December 2015 in 16 regional centers...
October 10, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28731420/adult-atopic-dermatitis-less-certainty-more-challenges
#13
M Megna, C Patruno, A Balato, M Napolitano, N Balato
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28704993/a-case-of-juvenile-amyopathic-dermatomyositis
#14
Maddalena Napolitano, Matteo Megna, Lorenzo Squillace, Claudia Costa, Massimiliano Scalvenzi
No abstract text is available yet for this article.
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28653445/systemic-treatment-for-psoriasis-and-malignancies-a-real-risk
#15
LETTER
Maddalena Napolitano, Matteo Megna, Angela Patrì, Anna Balato, Cataldo Patruno, Giuseppe Monfrecola, Nicola Balato
No abstract text is available yet for this article.
July 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28601309/the-aryl-hydrocarbon-receptor-as-an-antitumor-target-of-synthetic-curcuminoids-in-colorectal-cancer
#16
Bryant W Megna, Patrick R Carney, Mitchell G Depke, Manabu Nukaya, James McNally, Lesley Larsen, Rhonda J Rosengren, Gregory D Kennedy
BACKGROUND: Curcumin has proven to be a potent antitumor agent in both preclinical and clinical models of colorectal cancer (CRC). It has also been identified as a ligand of the transcription factor known as the aryl hydrocarbon receptor (AHR). Our laboratory has identified the AHR as a mechanism which contributes to both tumorigenesis in a mouse model of inflammatory CRC as well an apoptotic target in vitro. Curcumin's role as an AHR ligand may modulate its effects to induce colon cancer cell death, and this role may be enhanced via structural modification of the curcumin backbone...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28573823/the-effect-of-smartphone-addiction-on-hand-joints-in-psoriatic-patients-an-ultrasound-based-study
#17
M Megna, P Gisonni, M Napolitano, G Dell'Aversano Orabona, C Patruno, F Ayala, N Balato
BACKGROUND: Distal interphalangeal (DIP) arthritis is a frequent form of psoriatic arthritis being often linked to nail psoriasis. Modern society is characterized by overuse of smartphones. Indeed, literature has recently focalized on research into smartphone addiction and health-related problems. OBJECTIVES: As smartphone addiction is able to determine overuse and repeated movements of DIP joints and nails, the aim of this study was to evaluate the impact of smartphone use on hand joints of young psoriatic patients...
June 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28567556/minimal-disease-activity-in-patients-with-psoriatic-arthritis-treated-with-ustekinumab-results-from-a-24-week-real-world-study
#18
Maddalena Napolitano, Luisa Costa, Francesco Caso, Matteo Megna, Raffaele Scarpa, Nicola Balato, Fabio Ayala, Anna Balato
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease affecting around 40% of psoriasis patients. Minimal disease activity (MDA) criteria have been proposed to identify a state of low disease activity, one of the principal goals of treatment for psoriatic disease. This study investigated treatment with ustekinumab (UST) in the context of a real-world setting. Thirty-four PsA patients who had failure or inadequate response to conventional synthetic disease-modifying antirheumatic drugs or to anti-tumour necrosis factor alpha were enrolled...
July 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28560220/medical-and-surgical-treatment-of-hidradenitis-suppurativa-a-review
#19
REVIEW
Nicolò Scuderi, Ambra Monfrecola, Luca Andrea Dessy, Gabriella Fabbrocini, Matteo Megna, Giuseppe Monfrecola
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with painful nodules, abscesses, sinus tracts, and scarring primarily affecting apocrine gland-rich intertriginous areas. HS prevalence ranges from 0.05 to 1%. The central pathogenic event in HS is believed to be the occlusion of the upper part of the folliculopilosebaceous unit, leading to the rupture of the sebofollicular canal with the consequent development of perifollicular lymphohistiocytic inflammation. The HS treatment choices are influenced by disease severity and its individual subjective impact, involving both medical and surgical interventions...
May 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28528541/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#20
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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