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https://www.readbyqxmd.com/read/28731420/adult-atopic-dermatitis-less-certainty-more-challenges
#1
M Megna, C Patruno, A Balato, M Napolitano, N Balato
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28704993/a-case-of-juvenile-amyopathic-dermatomyositis
#2
Maddalena Napolitano, Matteo Megna, Lorenzo Squillace, Claudia Costa, Massimiliano Scalvenzi
No abstract text is available yet for this article.
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28653445/systemic-treatment-for-psoriasis-and-malignancies-a-real-risk
#3
Maddalena Napolitano, Matteo Megna, Angela Patrì, Anna Balato, Cataldo Patruno, Giuseppe Monfrecola, Nicola Balato
No abstract text is available yet for this article.
June 26, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28601309/the-aryl-hydrocarbon-receptor-as-an-antitumor-target-of-synthetic-curcuminoids-in-colorectal-cancer
#4
Bryant W Megna, Patrick R Carney, Mitchell G Depke, Manabu Nukaya, James McNally, Lesley Larsen, Rhonda J Rosengren, Gregory D Kennedy
BACKGROUND: Curcumin has proven to be a potent antitumor agent in both preclinical and clinical models of colorectal cancer (CRC). It has also been identified as a ligand of the transcription factor known as the aryl hydrocarbon receptor (AHR). Our laboratory has identified the AHR as a mechanism which contributes to both tumorigenesis in a mouse model of inflammatory CRC as well an apoptotic target in vitro. Curcumin's role as an AHR ligand may modulate its effects to induce colon cancer cell death, and this role may be enhanced via structural modification of the curcumin backbone...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28573823/the-effect-of-smartphone-addiction-on-hand-joints-in-psoriatic-patients-an-ultrasound-based-study
#5
M Megna, P Gisonni, M Napolitano, G Dell'Aversano Orabona, C Patruno, F Ayala, N Balato
BACKGROUND: Distal interphalangeal (DIP) arthritis is a frequent form of psoriatic arthritis being often linked to nail psoriasis. Modern society is characterized by overuse of smartphones. Indeed, literature has recently focalized on research into smartphone addiction and health-related problems. OBJECTIVES: As smartphone addiction is able to determine overuse and repeated movements of DIP joints and nails, the aim of this study was to evaluate the impact of smartphone use on hand joints of young psoriatic patients...
June 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28567556/minimal-disease-activity-in-patients-with-psoriatic-arthritis-treated-with-ustekinumab-results-from-a-24-week-real-world-study
#6
Maddalena Napolitano, Luisa Costa, Francesco Caso, Matteo Megna, Raffaele Scarpa, Nicola Balato, Fabio Ayala, Anna Balato
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease affecting around 40% of psoriasis patients. Minimal disease activity (MDA) criteria have been proposed to identify a state of low disease activity, one of the principal goals of treatment for psoriatic disease. This study investigated treatment with ustekinumab (UST) in the context of a real-world setting. Thirty-four PsA patients who had failure or inadequate response to conventional synthetic disease-modifying antirheumatic drugs or to anti-tumour necrosis factor alpha were enrolled...
May 31, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28560220/medical-and-surgical-treatment-of-hidradenitis-suppurativa-a-review
#7
REVIEW
Nicolò Scuderi, Ambra Monfrecola, Luca Andrea Dessy, Gabriella Fabbrocini, Matteo Megna, Giuseppe Monfrecola
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with painful nodules, abscesses, sinus tracts, and scarring primarily affecting apocrine gland-rich intertriginous areas. HS prevalence ranges from 0.05 to 1%. The central pathogenic event in HS is believed to be the occlusion of the upper part of the folliculopilosebaceous unit, leading to the rupture of the sebofollicular canal with the consequent development of perifollicular lymphohistiocytic inflammation. The HS treatment choices are influenced by disease severity and its individual subjective impact, involving both medical and surgical interventions...
May 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28528541/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#8
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28509525/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#9
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28509523/skin-diseases-and-tattoos-a-five-year-experience
#10
Maddalena Napolitano, Matteo Megna, Milena Cappello, Caterina Mazzella, Cataldo Patruno
BACKGROUND: Decorative tattooing as a body art form underwent an exponential increase during the last two decades, particularly among teenagers and young adults. Consequently, the number of reported adverse reactions after tattooing has increased. The most frequent reported skin reactions to tattoo include infectious (bacterial, viral, fungal) or inflammatory (allergic contact dermatitis and granulomatous reaction) diseases. Moreover, tattoos can also induce the development of typical skin lesions of pre-existing dermatoses, a phenomenon known as isomorphism reactive or Koëbner phenomenon, which commonly occurs in patients with psoriasis, vitiligo, or lichen planus...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28458570/hidradenitis-suppurativa-from-pathogenesis-to-diagnosis-and-treatment
#11
REVIEW
Maddalena Napolitano, Matteo Megna, Elena A Timoshchuk, Cataldo Patruno, Nicola Balato, Gabriella Fabbrocini, Giuseppe Monfrecola
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presenting with painful nodules, abscesses, sinus tracts, and scarring. HS is a multifactorial disease in which genetic and environmental factors play a key role. The primary defect in HS pathophysiology involves follicular occlusion of the folliculopilosebaceous unit, followed by follicular rupture, and immune responses (perifollicular lympho-histiocytic inflammation), finally leading to the development of clinical HS lesions...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28432437/an-italian-multicentre-study-on-adult-atopic-dermatitis-persistent-versus-adult-onset-disease
#12
Matteo Megna, Cataldo Patruno, Anna Balato, Franco Rongioletti, Luca Stingeni, Nicola Balato
Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease which predominantly affects children. However, AD may persist until adulthood (persistent AD), or directly start in adults (adult-onset AD). AD often shows a non-flexural rash distribution, and atypical morphologic variants in adults and specific diagnostic criteria are lacking. Moreover, adult AD prevalence as well as detailed data which can characterize persistent vs adult-onset subtype are scant. The aim of this study was to investigate on the main features of adult AD particularly highlighting differences between persistent vs adult-onset form...
August 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28399618/psoriasis-and-high-school-students-an-educational-approach
#13
Maddalena Napolitano, Matteo Megna, Cataldo Patruno, Angela Patrì, Massimiliano Scalvenzi, Giuseppe Monfrecola, Fabio Ayala, Nicola Balato
BACKGROUND: To date, no study evaluating the knowledge of psoriasis among high school students has been conducted. Thus, we aimed to examine the awareness of such disease among teenagers as well as the possible changes in both the perception of psoriasis and comprehension level after an interactive lesson. METHODS: A school-based survey was conducted in March 2016 on 300 high school students aged 14-18 years. The survey followed a three-step process. Initially, the questionnaire was administered to students in a 30 minutes period...
April 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28329612/aquagenic-wrinkling-of-the-palms-a-case-report-and-literature-review
#14
Matteo Megna, Mariateresa Cantelli, Donata Martellotta, Gabriella Calabrò, Anna Balato, Fabio Ayala
Aquagenic wrinkling of the palms (AWP) is an unusual and rare dermatological condition characterized by excessive palmar wrinkling, occurring within a few minutes of water exposure. Cystic fibrosis (CF) or CF carrier state associated forms, drug induced cases, and idiopathic forms have been described. We report the case of a 27-year-old woman with a 7-year history of transient excessive wrinkling of her palms after brief exposure to water. We present also a comprehensive review of the literature. We believe that AWP has been underdiagnosed thus far and we would like to encourage investigations such as sweat chloride test or genetic studies in these patients because of the association with CF or CF carrier state, particularly when AWP appears in younger ages...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28297009/development-and-validation-of-a-prognostic-score-for-intrahepatic-cholangiocarcinoma
#15
Mustafa Raoof, Sinziana Dumitra, Philip H G Ituarte, Laleh Melstrom, Susanne G Warner, Yuman Fong, Gagandeep Singh
Importance: In patients with intrahepatic cholangiocarcinoma (ICC), the oncologic benefit of surgery and perioperative outcomes for large multifocal tumors or tumors with contiguous organ involvement remain to be defined. Objectives: To develop and externally validate a simplified prognostic score for ICC and to determine perioperative outcomes for large multifocal ICCs or tumors with contiguous organ involvement. Design, Setting, and Participants: This study of a contemporary cohort merged data from the California Cancer Registry (January 1, 2004, through December 31, 2011) and the Office of Statewide Health Planning and Development inpatient database...
May 17, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28273984/study-of-risk-factors-for-development-of-voice-disorders-and-its-impact-on-the-quality-of-life-of-school-teachers-in-mangalore-india
#16
Arati Alva, Megna Machado, Kiran Bhojwani, Suja Sreedharan
INTRODUCTION: School teachers are most prone to the development and detrimental effects of voice disorders as a consequence of their work. The risk factors for development of dysphonia in teachers are multifactorial. AIM: The primary aim of our study was to investigate the various risk factors that influence the onset and progression of voice disorders in school teachers in the Indian context. We wanted to assess the effect of voice problems on the physical, psychosocial and functional aspect of a teacher's life...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28217485/skindia-quiz-32-a-strange-sessile-formation-appearing-as-a-penis-like-structure
#17
Matteo Megna, Nicola Balato, Maddalena Napolitano, Claudia Costa, Pietro Gisonni, Massimo Mascolo, Anna Balato
No abstract text is available yet for this article.
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28209050/-active-photoprotection-sunscreens-with-dna-repair-enzymes
#18
Matteo Megna, Serena Lembo, Nicola Balato, Giuseppe Monfrecola
Ultraviolet (UV) radiation exerts different harmful effects on human health, being the main etiological agent of certain skin cancers and photoaging. In this context, photoprotection, intended as a set of measures adopted to limit and prevent the effects of UV radiation, plays a critical role in avoiding undesired sunlight outcomes. Traditional sunscreens represent a widely used photoprotective approach, even if they exert a "passive photoprotection" and are not effective once damage to skin cells has been generated after sun exposure...
June 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28209048/waste-exposure-and-skin-diseases
#19
Matteo Megna, Maddalena Napolitano, Claudia Costa, Nicola Balato, Cataldo Patruno
Waste is a composite mixture of different substances including endotoxins, organic dust and bio-aerosol stuffed with micro-organisms, as well as various toxic organic and inorganic chemicals, which may be intrinsically hazardous to human health. Therefore, health risks may derive from direct or indirect contact with garbage. Although few epidemiological and clinical surveys investigated on the adverse effects of garbage exposure on human health, particularly regarding respiratory, gastrointestinal, musculoskeletal and mucous membranes systems, only very limited data are available on the relationship between waste exposure and cutaneous diseases...
February 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28191631/the-role-of-histological-presentation-in-erythroderma
#20
Matteo Megna, Akmal A Sidikov, Denis V Zaslavsky, Igor N Chuprov, Elena A Timoshchuk, Uliya Egorova, Joerg Wenzel, Ruslan A Nasyrov
BACKGROUND: Erythroderma is a serious medical condition characterized by inflamed red skin involving over 90% of the body. It can be the common presentation of different diseases, therefore clinical diagnosis can be problematic. Controversial data are reported regarding the diagnostic value of histological examination in erythroderma subjects. METHODS: A retrospective study was performed, investigating histological skin specimens of patients with a clinical diagnosis of erythroderma admitted to the Department of Dermatology of State Pediatric Medical University, Saint Petersburg, from 2001 to 2014...
April 2017: International Journal of Dermatology
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