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Maddalena Napolitano, Nicola Balato, Francesco Caso, Luisa Costa, Matteo Megna, Teresa Cirillo, Anna Balato, Raffaele Scarpa
OBJECTIVES: To evaluate the incidence of new cases of psoriatic arthritis (PsA) in patients with plaque psoriasis receiving biologic drugs. METHODS: A retrospective study was performed on 434 psoriatic patients under biologic treatment, attending the Psoriasis Care Centre of Dermatology at the University Federico II of Naples from January 2011 to November 2015. As part of the routine clinical practice, assessment of disease activity was made at baseline, and every 3 months...
September 8, 2016: Clinical and Experimental Rheumatology
F Barchetti, A Stagnitti, V Megna, N Al Ansari, A Marini, D Musio, M L Monti, G Barchetti, V Tombolini, C Catalano, V Panebianco
OBJECTIVE: The aim of this study was to evaluate the accuracy of unenhanced whole-body MRI, including whole-body Diffusion Weighted Imaging (DWI), used as a diagnostic modality to detect  pathologic lymph nodes and skeletal metastases in patients with prostate cancer (PCa) undergoing restaging after primary treatment. PATIENTS AND METHODS: 152 male patients with biochemical recurrence after radical prostatectomy (RP) or external beam radiation therapy (EBRT) underwent MRI at a 1...
September 2016: European Review for Medical and Pharmacological Sciences
M Magliulo, R Megna, L Cella, R Liuzzi, G Palma, R Pacelli
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Matteo Megna, Antonio Lobasso, Maddalena Napolitano, Francesca Wanda Rossi, Anna Balato, Caterina Matucci-Cerinic, Francesco Braconaro, Francesca Prignano, Giuseppe Monfrecola, Nicola Balato, Amato De Paulis
Psoriasis is a systemic disease linked to a general state of inflammation and increased risk to develop metabolic and cardiovascular diseases such as obesity, diabetes, and hypertension.(1,2) Physical activity, a vital component in prevention and management of these diseases, is reported to be potentially associated in a negative way with psoriasis, since the latter often cause significant restriction of social activities.(3) The interest in the relationship between exercise and psoriasis is constantly growing...
September 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Giulio E Lancioni, Nirbhay Singh, Mark F O'Reilly, Jeff Sigafoos, Fiora D'Amico, Francesca Buonocunto, Jorge Navarro, Crocifissa Lanzilotti, Pietro Fiore, Marisa Megna, Sabino Damiani, Riccardo Marvulli
BACKGROUND: Post-coma persons in a minimally conscious state (MCS) and with extensive motor impairment cannot independently access and control environmental stimulation. AIM: Assessing the effects of a microswitch-aided program aimed at helping MCS persons develop responding and stimulation control and conducting a social validation/evaluation of the program. DESIGN: A single-subject ABAB design was used for each participant to determine the impact of the program on his or her responding...
September 1, 2016: European Journal of Physical and Rehabilitation Medicine
Bryant W Megna, Patrick R Carney, Manabu Nukaya, Pete Geiger, Gregory D Kennedy
BACKGROUND: Even with colonoscopy screening and preventive measures becoming more commonplace, colorectal cancer (CRC) remains the third leading cause of oncologic death in the United States as of 2014. Many chemotherapeutics exist for the treatment of colorectal cancer, though they often come with significant side effect profiles or narrow efficacy ranges in terms of patient profile. Dietary phytochemicals such as glucobrassicin and its metabolite indole-3-carbinol (I3C) have been implicated in tumor prevention in many preclinical models across a variety of gastrointestinal tumors and represent an intriguing new class of natural chemotherapeutics for CRC...
July 2016: Journal of Surgical Research
Carol J Díaz-Díaz, Sean M Ronnekleiv-Kelly, Manabu Nukaya, Peter G Geiger, Silvia Balbo, Romel Dator, Bryant W Megna, Patrick R Carney, Christopher A Bradfield, Gregory D Kennedy
OBJECTIVE: To determine the role of the aryl hydrocarbon receptor (AHR) in colitis-associated colorectal tumorigenesis. BACKGROUND: Colorectal cancer (CRC) is the third most commonly diagnosed cancer in United States. Chronic intestinal inflammation increases the risk for the development of CRC. We investigated the involvement of AHR, a ligand-activated transcriptional regulator, in colitis-associated colorectal tumorigenesis. METHODS: We used a mouse model of colitis-associated colorectal tumorigenesis that employs treatment with azoxymethane and dextran sodium sulfate...
September 2016: Annals of Surgery
Matteo Megna, Maddalena Napolitano, Fabio Ayala, Nicola Balato
No abstract text is available yet for this article.
June 7, 2016: Indian Journal of Dermatology, Venereology and Leprology
Matteo Megna, Maddalena Napolitano, Claudia Costa, Massimo Mascolo, Massimiliano Scalvenzi
No abstract text is available yet for this article.
April 2016: Dermatology Practical & Conceptual
Maddalena Napolitano, Francesco Caso, Raffaele Scarpa, Matteo Megna, Angela Patrì, Nicola Balato, Luisa Costa
Psoriasis frequency ranges from 1 to 3 % in white population, and arthritis occurs in 10-40 % of psoriasis patients, representing a relevant health issue. Psoriatic arthritis (PsA) is an inflammatory arthropathy, associated with psoriasis, in which ocular-, intestinal-, metabolic-, and cardiovascular-related manifestations can variably coexist. In order to favor early PsA and psoriasis diagnosis, it is crucial to rule out other conditions that can resemble the disease and delay appropriate therapeutic approach...
August 2016: Clinical Rheumatology
Maria Schiattarella, Cataldo Patruno, Nicola Balato, Luigi Canta, Giuseppina Caiazzo, Serena Lembo, Matteo Megna, Fabio Ayala, Anna Balato
BACKGROUND: Chronic hand eczema (CHE) is not a homogenous disease, necessitating complex differential diagnostics. Interleukin (IL)-1 family members are significantly up-regulated in ACD and psoriasis patients skin. METHODS: The present study aims to deepen the knowledge about clinical assessment and characterization of patients affected by chronic hand dermatitis (CHD) as well as to investigate the role of possible biomarkers which may help in the diagnostic process...
April 1, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Maddalena Napolitano, Matteo Megna, Anna Balato, Fabio Ayala, Serena Lembo, Alessia Villani, Nicola Balato
Psoriasis is a chronic, immune-mediated, inflammatory skin disease, affecting 1-3% of the white population. Although the existence of two psoriasis incidence peaks has been suggested (one in adolescence before 20 years of age and another in adulthood), its onset may occur at any age, including childhood and adolescence, in which the incidence is now estimated at 40.8 per 100,000. As for adult psoriasis, pediatric psoriasis has recently been associated with obesity, metabolic syndrome, increased waist circumference percentiles and metabolic laboratory abnormalities, warranting early monitoring and lifestyle modifications...
June 2016: Dermatology and Therapy
Matteo Gramanzini, Sara Gargiulo, Fernando Zarone, Rosario Megna, Antonio Apicella, Raffaella Aversa, Marco Salvatore, Marcello Mancini, Roberto Sorrentino, Arturo Brunetti
OBJECTIVES: To present a practical approach that combines biomechanical tests, microcomputed tomography (μCT) and histomorphometry, providing quantitative results on bone structure and mechanical properties in a minipig model, in order to investigate the specific response to an innovative dental biomaterial. METHODS: Titanium implants with innovative three-dimensional scaffolds were inserted in the tibias of 4 minipigs. Primary stability and osseointegration were investigated by means of insertion torque (IT) values, resonance frequency analysis (RFA), bone-to-implant contact (BIC), bone mineral density (BMD) and stereological measures of trabecular bone...
June 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Bryant W Megna, Patrick R Carney, Gregory D Kennedy
Inflammatory bowel disease (IBD) is a chronic intestinal illness of autoimmune origin affecting millions across the globe. The most common subtypes include ulcerative colitis (UC) and Crohn's disease. While many medical treatments for IBD exist, none come without the risk of significant immunosuppression and in general do not have benign side effect profiles. Surgical intervention exists only as radical resection for medically refractory UC. There exists a dire need for novel treatments that target the inherent pathophysiologic disturbances of IBD, rather than global immune suppression...
February 27, 2016: World Journal of Gastrointestinal Surgery
Marvulli Riccardo, Lopopolo Angela, Dantone Angela, Palmisano Vita, Lancioni Giulio, Fiore Pietroq, Ianieri Giancarlo, Megna Marisa
The Hereditary Spastic Paraparesis (HSP) or Strumpell-Lorrain disease is a heterogeneous neurodegenerative disease of the spinal cord. It is genetically transmitted and characterized by a progressive muscle weakness, spasticity of the lower limbs and awkward gain. There is no specific pharmacological treatment. The pharmacological therapy decreases the muscle tone and prevents stiffening). Physiotherapy restrains the progression of muscle atrophy, delays contraction of the tendons and gives greater mobility to people affected by the disease...
2016: Current Pharmaceutical Design
M Megna, M Napolitano, N Balato, M Scalvenzi, F Ayala, L Di Costanzo, S Lembo, R Di Caprio, C Patruno, A Balato
BACKGROUND: Melanoma is an immunogenic tumor and the presence of T-cell infiltrates within melanoma lesions may correlated with longer patient survival. Psoriasis is a chronic immune- mediated inflammatory disease, in which the role of T-cells is well established. OBJECTIVES: The aim of our prospective pilot study was to investigate the relationship between melanoma and psoriasis examining 3 groups of patients: Melanoma-group (MG), Psoriasis-group (PG) and Control-group (CG)...
December 3, 2015: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
James L Megna, Alka Aneja, Marie Sauro, Naseer Ahmad, Mihai Simionescu, Georgian Mustata, Mariela Herrera Rojas, Michael Wade
INTRODUCTION: Inpatient psychiatric units experience significant pressure from third party payers to keep length of stay (LOS) to a minimum despite having to treat more severely ill patients. However, there is a paucity of empiric data for guiding treatment decisions that maximize therapeutic outcome while minimizing LOS. We therefore endeavored to begin utilizing a newly created psychometric instrument that assesses patient psychological factors, which we propose will allow for LOS prediction and individualization of therapeutic outcome...
November 2015: Comprehensive Psychiatry
M Megna, V Bettoli, S Chimenti, A Chiricozzi, L Naldi, A Virgili, G Girolomoni, G Monfrecola
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by nodules, abscesses and sinus tracts, primarily affecting the intertriginous areas. The occlusion of the upper part of the folliculopilosebaceous unit, leading to rupture of the sebofollicular canal with the consequent development of perifollicular lympho-histiocytic inflammation, is believed to be the initial pathogenic event in HS. Giving the chronic nature of HS, its destructive impact on social, working and daily life of patients, its management is often frustrating both for patients and physicians...
December 2015: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Evaristo Ettorre, Francesco Saverio Bersani, Fabiola Colella, Adriana Servello, Amedeo Minichino, Valentina Megna, Mauro Liberatore, Massimo Biondi, Vincenzo Marigliano
It is described the case of a 74-years-old woman with probable Alzheimer Disease who showed good clinical response to rivastigmine associated with relevant improvement of cerebral perfusion after 1 year of treatment. The single-photon emission computed tomography (SPECT) scan showed a significant improvement in cortical uptake of the tracer in temporo-parietal and frontal regions in comparison to the examination performed before the treatment.
July 2015: Rivista di Psichiatria
M Napolitano, N Balato, F Ayala, C Patruno, A Patrì, M Megna, A Balato
BACKGROUND: Psoriasis management in elderly may be difficult, mainly due to comorbidities and concomitant medications. OBJECTIVE: To compare elderly and non elderly psoriatic patients in relation to their demographic, clinical and molecular characteristics. METHODS: A prospective observational study on 502 psoriatic patients attending our outpatient clinic was performed. We analyzed their demographical and clinical features, highlighting differences in comorbidities and treatment adverse events...
July 22, 2015: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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