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JOURNAL ARTICLE
Tessa Herman, Natalie Wilson, Nicha Wongjarupong, Bryant Megna, Vijay Are, Susan Lou, Mohammad Bilal, Brian Hanson
No abstract text is available yet for this article.
April 2024: VideoGIE
#2
REVIEW
Luca Potestio, Fabrizio Martora, Giuseppe Lauletta, Ylenia Vallone, Teresa Battista, Matteo Megna
Psoriasis pathogenesis is influenced by genetic factors and characterized by a complex interplay between genetic predisposition and various environmental triggers. These triggers set off metabolic processes involving inflammation, cell signaling, immune response dysregulation, and antigen presentation. Several types of innate and adaptive immune cells are involved in psoriasis. Among the cytokine cascade which leads to psoriasis development, the interleukin (IL)-23/Th17 axis, especially IL-17 production, emerges as crucial...
2024: Clinical, Cosmetic and Investigational Dermatology
#3
JOURNAL ARTICLE
Giacomo Farì, Francesco Quarta, Sara Clelia Longo, Laura Masiero, Vincenzo Ricci, Daniele Coraci, Laura Caforio, Marisa Megna, Maurizio Ranieri, Giustino Varrassi, Andrea Bernetti
OBJECTIVES: The aim of this study was to investigate the mechanism of falls in male elite wheelchair basketball (WB) players and to analyse the falls characteristics considering their classification score which ranges from 1.0 to 4.5 and it is related to their functional capacity and particularly to their volume of action. DESIGN: A cross-sectional video analysis was conducted using European para championships 2023official match videos. SETTING: Players of the sample team were divided into 2 groups according to their classification point: low-point players (LPP) and high-point players (HPP)...
April 9, 2024: Physical Therapy in Sport
#4
JOURNAL ARTICLE
Teresa Battista, Lucia Gallo, Fabrizio Martora, Davide Fattore, Luca Potestio, Sara Cacciapuoti, Massimiliano Scalvenzi, Matteo Megna
Background : It is now recognized that psoriasis plays a key role in the development of several comorbidities, such as cardiovascular disease, and metabolic syndrome. Some authors have hypothesized that patients with psoriasis may have an increased risk of developing certain types of cancer. The efficacy and safety of biologic drugs are well-documented in clinical trials and in real-life studies. However, there is limited evidence on the safety of the use of biologic treatments in cancer patients with psoriasis, and the use of this therapeutic class in patients with a pre-existing or concomitant malignancy is still debated...
March 27, 2024: Journal of Clinical Medicine
#5
REVIEW
Luca Potestio, Nello Tommasino, Giuseppe Lauletta, Fabrizio Martora, Matteo Megna
Psoriasis is now considered a systemic disease, and several comorbidities have been described such as cardiovascular diseases, neurologic and psychiatric disorders, chronic inflammatory bowel disease, psoriatic arthritis, etc. Regarding cardiovascular comorbidities, major adverse cardiovascular events have been reported in psoriasis patients by multiple epidemiologic studies. Moreover, smoking, obesity, metabolic syndrome, hypertension, dyslipidemia, diabetes and reduced physical activity are associated with psoriasis, increasing cardiovascular risk...
April 9, 2024: Dermatology and Therapy
#6
JOURNAL ARTICLE
M Spadafora, A Megna, N Lippolis, M Cavicchi, S Borsari, S Piana, S Guida, S Kaleci, J Chester, G Pellacani, C Longo
BACKGROUND: Differential diagnosis of amelanotic/hypomelanotic melanoma among solitary flat pink lesions is challenging, due to limited clinical and dermoscopic clues. Dermoscopy and reflectance confocal microscopy assessments improve diagnostic accuracy, but their combined capacity among solitary flat pink lesions is yet to be defined. OBJECTIVES: To determine (i) whether diagnostic accuracy is improved with combined dermoscopy and reflectance confocal microscopy, (ii) a model to estimate probability of flat amelanotic/hypomelanotic melanoma among solitary flat pink lesions...
April 4, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#7
Sarah Garikana, Pratik Jain, James L Megna, Luba Leontieva
In this paper, we report an atypical presentation of borderline personality disorder (BPD) in a 30-year-old female with a history of childhood molestation and trauma and a prior diagnosis of post-traumatic stress disorder (PTSD). The patient was hospitalized due to anxiety, depression, and guilt over her relapse into alcohol use disorder. During her hospital stay, we diagnosed her with BPD based on psychiatric examination, clinical interviews, and patient history. While the patient exhibited some of the typical characteristics of BPD, such as an instability of interpersonal and romantic relationships, there were numerous findings that were atypical of BPD...
February 2024: Curēus
#8
JOURNAL ARTICLE
Ludovica Verde, Evelyn Frias-Toral, Sara Cacciapuoti, Daniel Simancas-Racines, Matteo Megna, Giuseppina Caiazzo, Luca Potestio, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri, Luigi Barrea
BACKGROUND: Acne, a chronic inflammatory disease impacting the pilosebaceous unit, is influenced significantly by inflammation and oxidative stress, and is commonly associated with obesity. Similarly, obesity is also associated with increased inflammation and oxidation. The role of diet in acne remains inconclusive, but the very low-calorie ketogenic diet (VLCKD), known for weight loss and generating anti-inflammatory ketone bodies, presents promising potential. Despite this, the effects of VLCKD on acne remain underexplored...
March 31, 2024: Journal of Translational Medicine
#9
REVIEW
Nello Tommasino, Matteo Megna, Sara Cacciapuoti, Alessia Villani, Fabrizio Martora, Angelo Ruggiero, Lucia Genco, Luca Potestio
Teledermatology may be defined as the application of telemedicine to dermatology. According to published data, teledermatology is more widespread in Europe and North America, probably where resources for health care are greater than in other areas of the world. Indeed, teledermatology requires advanced technology to be efficient, as high image quality is necessary to allow the dermatologist to make correct diagnoses. Thanks to the recent advances in this field, teledermatology is become routinary in daily clinical practice...
2024: Clinical, Cosmetic and Investigational Dermatology
#10
JOURNAL ARTICLE
Megna Jeram, Christin Coomarasamy, Andrew Donald MacCormick
PURPOSE: A potential complication of bariatric surgery is development of nutritional deficiencies. Study aims were to assess prevalence of micronutrient deficiencies in preoperative bariatric patients and to examine for ethnic differences. METHODS: Retrospective analysis of 573 patients that underwent bariatric surgery at Counties Manukau District Health Board was carried out. Mean preoperative levels of albumin, calcium, phosphate, folate, vitamin B12, vitamin D, magnesium, haemoglobin, haematocrit, mean cell volume, mean cell haemoglobin, ferritin, iron, and transferrin were calculated...
March 25, 2024: Obesity Surgery
#11
JOURNAL ARTICLE
Luca Potestio, Matteo Megna, Sara Cacciapuoti, Fabrizio Martora, Alessia Villani
No abstract text is available yet for this article.
March 22, 2024: Clinical and Experimental Dermatology
#12
Fabrizio Martora, Teresa Battista, Luca Potestio, Antonio Portarapillo, Nello Tommasino, Matteo Megna
Managing HS has long posed a significant challenge for dermatologists. Adalimumab stands as the sole biologic drug sanctioned for HS, receiving approval in 2015 as an anti-tumor necrosis factor (TNF)-α drug. Real-life evidence over the years has debated its efficacy, suggesting a success rate hovering around 70%. However, the variability in existing treatments and the chronic-recurrent nature of the condition make its treatment and management exceedingly challenging. Hence, identifying new therapeutic targets for HS in the future becomes imperative...
2024: Clinical, Cosmetic and Investigational Dermatology
#13
JOURNAL ARTICLE
Andrea Zaffora, Bartolomeo Megna, Barbara Seminara, Francesco Di Franco, Monica Santamaria
Next-generation alkaline water electrolyzers will be based on zero-gap configuration to further reduce costs related to technology and to improve performance. Here, anodic porous transport layers (PTLs) for zero-gap alkaline electrolysis are prepared through a facile one-step electrodeposition of Ni,Fe,Co-based layered double hydroxides (LDH) on 304 stainless steel (SS) meshes. Electrodeposited LDH structures are characterized using Scanning Electron Microscopy (SEM) confirming the formation of high surface area catalytic layers...
February 23, 2024: Nanomaterials
#14
REVIEW
Paolo Dapavo, Martina Burlando, Claudio Guarneri, Matteo Megna, Alessandra Narcisi, Marina Talamonti, Paolo Gisondi
INTRODUCTION: The introduction of biologics for the treatment of plaque psoriasis is one of the major therapeutic advances of the last decades in dermatology. The efficacy of this class of drugs can be influenced by multiple factors including obesity, being overweight, prior treatment failures, and disease severity. AREAS COVERED: Most of the currently available approved biologics are limited by their lack of dosing flexibility for adapting the therapy to the complexity of real-world patients with psoriasis...
March 5, 2024: Expert Opinion on Biological Therapy
#15
JOURNAL ARTICLE
Enikö Sonkoly, Julia-Tatjana Maul, Matteo Megna, Patricia Gorecki, Edmée Crombag, Jozefien Buyze, Laura Savage
Scalp psoriasis affects approximately 80% of patients with psoriasis and can negatively impact their quality of life. This post hoc analysis of the VOYAGE 2 Phase III randomized clinical trial evaluated scalp response to guselkumab treatment and its association with skin response and patient-reported outcomes. The study included patients with moderate-to-severe plaque psoriasis and baseline scalp psoriasis who were initially randomized to receive guselkumab. Patients were divided into 3 groups based on their achievement of a Psoriasis Area and Severity Index 90 response at week 28: responder continuation, non-responder continuation and responder withdrawal...
March 4, 2024: Acta Dermato-venereologica
#16
COMMENT
Luca Potestio, Fabrizio Martora, Sara Cacciapuoti, Matteo Megna, Alessia Villani, Angelo Ruggiero
No abstract text is available yet for this article.
2024: Clinical, Cosmetic and Investigational Dermatology
#17
JOURNAL ARTICLE
Diego Orsini, Piergiorgio Malagoli, Anna Balato, Luca Bianchi, Pina Brianti, Dario Buononato, Martina Burlando, Giacomo Caldarola, Anna Campanati, Elena Campione, Carlo G Carrera, Andrea Carugno, Francesco Cusano, Paolo Dapavo, Annunziata Dattola, Clara De Simone, Valentina Dini, Maria Esposito, Maria C Fargnoli, Francesca M Gaiani, Luigi Gargiulo, Paolo Gisondi, Alessandro Giunta, Luciano Ibba, Claudia Lasagni, Francesco Loconsole, Vincenzo Maione, Edoardo Mortato, Angelo V Marzano, Martina Maurelli, Matteo Megna, Santo R Mercuri, Alessandra Narcisi, Annamaria Offidani, Giovanni Paolino, Aurora Parodi, Giovanni Pellacani, Luca Potestio, Pietro Quaglino, Antonio G Richetta, Francesca Romano, Paolo Sena, Marina Venturini, Chiara Assorgi, Antonio Costanzo
INTRODUCTION: Genital involvement is observed in approximately 60% of patients with psoriasis, presenting clinicians with formidable challenges in treatment. While new biologic drugs have emerged as safe and effective options for managing psoriasis, their efficacy in challenging-to-treat areas remains inadequately explored. Intriguingly, studies have shown that interleukin (IL)-17 inhibitors exhibit effectiveness in addressing genital psoriasis. OBJECTIVES: We aimed to determine the effectiveness profile of bimekizumab in patients affected by moderate-to-severe plaque psoriasis with involvement of genitalia...
April 1, 2024: Dermatology Practical & Conceptual
#18
JOURNAL ARTICLE
Giacomo Farì, Rachele Mancini, Laura Dell'Anna, Vincenzo Ricci, Simone Della Tommasa, Francesco Paolo Bianchi, Ilaria Ladisa, Carlo De Serio, Silvia Fiore, Danilo Donati, Maurizio Ranieri, Andrea Bernetti, Marisa Megna
Background : Mild-to-moderate knee osteoarthritis (KOA) can be successfully treated using intra-articular hyaluronic acid (IA-HA). The medial infrapatellar (MIP) approach and lateral infrapatellar (LIP) approach are two of the most used techniques for performing IA-HA, but it is still not clear which one is preferable. Objectives : The study aims to find the best knee injection technique between MIP and LIP approaches. Methods: In total, 161 patients were enrolled, divided into two groups (MIP or LIP). Each technique was performed once a week for three weeks...
February 17, 2024: Journal of Clinical Medicine
#19
REVIEW
Valerio Sveva, Giacomo Farì, Annatonia Fai, Alessio Savina, Mattia Giuseppe Viva, Francesco Agostini, Maurizio Ranieri, Marisa Megna, Massimiliano Mangone, Marco Paoloni, Andrea Bernetti
Ultrasound-guided perineural hydrodissection (HD) is a novel technique that has been found to be effective in providing mechanical release of perineural adhesions and decompression of the nerve, reducing inflammation and edema and restoring its physiological function. It has a significant impact on chronic neuropathic pain (20 ± 4 weeks with VAS < 5 or VAS diminished by 2 points after the procedure). Carpal tunnel syndrome (CTS) is a common entrapment mononeuropathy, and its distribution is typically innervated by the median nerve...
January 30, 2024: Journal of Personalized Medicine
#20
Davide Fattore, Gianluca Esposito, Ludovica Carangelo, Maria Antonietta Luciano, Matteo Megna
INTRODUCTION: Immune checkpoint inhibitors are new drugs approved for the treatment of many types of malignancies. Despite their wide use and unquestionable clinical benefits, these agents have also been associated with a unique spectrum of side effects known as immune-related adverse events. In this study, we report the first case of atezolizumab-induced pustular psoriasis and acrodermatitis. CASE PRESENTATION: A 61-year-old woman presented to our department with erythematous-desquamative and pustular lesions involving all hands and feet fingers, inguinal region, and trunk, associated to severe psoriatic onychodystrophy...
2024: Case Reports in Dermatology
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