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https://www.readbyqxmd.com/read/29426754/chronic-inducible-urticarias-in-children
#1
Maddalena Napolitano, Matteo Megna, Claudia Costa, Nicola Balato, Cataldo Patruno
No abstract text is available yet for this article.
February 6, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29368852/a-case-of-aquagenic-wrinkling-of-the-palms
#2
Marianna Donnarumma, Matteo Megna, Maddalena Napolitano, Cataldo Patruno
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29368849/pyoderma-gangrenosum-successfully-treated-with-topical-tacrolimus
#3
Maddalena Napolitano, Matteo Megna, Angela Patrì, Giuseppe Monfrecola, Nicola Balato
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29315640/virological-patterns-of-hcv-patients-with-failure-to-interferon-free-regimens
#4
Starace Mario, Minichini Carmine, De Pascalis Stefania, Macera Margherita, Occhiello Laura, Messina Vincenzo, Sangiovanni Vincenzo, Adinolfi Luigi Elio, Claar Ernesto, Precone Davide, Stornaiuolo Gianfranca, Stanzione Maria, Ascione Tiziana, Caroprese Mara, Zampino Rosa, Parrilli Gianpaolo, Gentile Ivan, Brancaccio Giuseppina, Iovinella Vincenzo, Martini Salvatore, Masarone Mario, Fontanella Luca, Masiello Addolorata, Evangelista Sagnelli, Punzi Rodolfo, Salomone Megna Angelo, Santoro Renato, Gaeta Giovanni Battista, Coppola Nicola
BACKGROUND: The study characterized the virological patterns and the resistance-associated substitutions (RASs) in patients with failure to IFN-free regimens enrolled in the real-life setting. PATIENTS AND METHODS: All 87 consecutive HCV patients with failed IFN-free regimens, observed at the laboratory of the University of Campania, were enrolled. All patients had been treated with DAA regimens according to the HCV genotype, international guidelines and local availability...
January 9, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29023554/reproducibility-of-shear-wave-elastography-swe-in-patients-with-chronic-liver-disease
#5
Marcello Mancini, Angelo Salomone Megna, Monica Ragucci, Massimo De Luca, Giuseppina Marino Marsilia, Gerardo Nardone, Pietro Coccoli, Anna Prinster, Lorenzo Mannelli, Emilia Vergara, Serena Monti, Raffaele Liuzzi, Mariarosaria Incoronato
The presence of significant fibrosis is an indicator for liver disease staging and prognosis. The aim of the study was to determine reproducibility of real-time shear wave elastography using a hepatic biopsy as the reference standard to identify patients with chronic liver disease. Forty patients with chronic liver disease and 12 normal subjects received shear wave elastography performed by skilled operators. Interoperator reproducibility was studied in 29 patients. Fibrosis was evaluated using the Metavir score...
2017: PloS One
https://www.readbyqxmd.com/read/28994145/adherence-to-barcelona-clinic-liver-cancer-guidelines-in-field-practice-results-of-progetto-epatocarcinoma-campania
#6
Maria Guarino, Raffaella Tortora, Giorgio de Stefano, Carmine Coppola, Filomena Morisco, Angelo Salomone Megna, Francesco Izzo, Gerardo Nardone, Guido Piai, Luigi Elio Adinolfi, Giuseppe D'Adamo, Giovanni Battista Gaeta, Vincenzo Messina, Giampiero Francica, Vincenzo De Girolamo, Nicola Coppola, Marcello Persico, Giovan Giuseppe Di Costanzo
BACKGROUND: The BCLC algorithm is the standard system for clinical management of HCC. Data on adherence to this therapeutic paradigm are scarce. AIMS: This field-practice study aimed to provide a description of HCC cirrhotic patients in Southern Italy, to evaluate the adherence to BCLC guidelines and its impact on patients' survival. METHODS: We analyzed the region-wide Italian database of Progetto Epatocarcinoma Campania, which includes data of HCC cirrhotic patients, prospectively collected from January 2013 to December 2015 in 16 regional centers...
October 10, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28731420/adult-atopic-dermatitis-less-certainty-more-challenges
#7
M Megna, C Patruno, A Balato, M Napolitano, N Balato
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28704993/a-case-of-juvenile-amyopathic-dermatomyositis
#8
Maddalena Napolitano, Matteo Megna, Lorenzo Squillace, Claudia Costa, Massimiliano Scalvenzi
No abstract text is available yet for this article.
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28653445/systemic-treatment-for-psoriasis-and-malignancies-a-real-risk
#9
LETTER
Maddalena Napolitano, Matteo Megna, Angela Patrì, Anna Balato, Cataldo Patruno, Giuseppe Monfrecola, Nicola Balato
No abstract text is available yet for this article.
July 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28601309/the-aryl-hydrocarbon-receptor-as-an-antitumor-target-of-synthetic-curcuminoids-in-colorectal-cancer
#10
Bryant W Megna, Patrick R Carney, Mitchell G Depke, Manabu Nukaya, James McNally, Lesley Larsen, Rhonda J Rosengren, Gregory D Kennedy
BACKGROUND: Curcumin has proven to be a potent antitumor agent in both preclinical and clinical models of colorectal cancer (CRC). It has also been identified as a ligand of the transcription factor known as the aryl hydrocarbon receptor (AHR). Our laboratory has identified the AHR as a mechanism which contributes to both tumorigenesis in a mouse model of inflammatory CRC as well an apoptotic target in vitro. Curcumin's role as an AHR ligand may modulate its effects to induce colon cancer cell death, and this role may be enhanced via structural modification of the curcumin backbone...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28573823/the-effect-of-smartphone-addiction-on-hand-joints-in-psoriatic-patients-an-ultrasound-based-study
#11
M Megna, P Gisonni, M Napolitano, G Dell'Aversano Orabona, C Patruno, F Ayala, N Balato
BACKGROUND: Distal interphalangeal (DIP) arthritis is a frequent form of psoriatic arthritis being often linked to nail psoriasis. Modern society is characterized by overuse of smartphones. Indeed, literature has recently focalized on research into smartphone addiction and health-related problems. OBJECTIVES: As smartphone addiction is able to determine overuse and repeated movements of DIP joints and nails, the aim of this study was to evaluate the impact of smartphone use on hand joints of young psoriatic patients...
June 2, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28567556/minimal-disease-activity-in-patients-with-psoriatic-arthritis-treated-with-ustekinumab-results-from-a-24-week-real-world-study
#12
Maddalena Napolitano, Luisa Costa, Francesco Caso, Matteo Megna, Raffaele Scarpa, Nicola Balato, Fabio Ayala, Anna Balato
Psoriatic arthritis (PsA) is a chronic inflammatory joint disease affecting around 40% of psoriasis patients. Minimal disease activity (MDA) criteria have been proposed to identify a state of low disease activity, one of the principal goals of treatment for psoriatic disease. This study investigated treatment with ustekinumab (UST) in the context of a real-world setting. Thirty-four PsA patients who had failure or inadequate response to conventional synthetic disease-modifying antirheumatic drugs or to anti-tumour necrosis factor alpha were enrolled...
July 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28560220/medical-and-surgical-treatment-of-hidradenitis-suppurativa-a-review
#13
REVIEW
Nicolò Scuderi, Ambra Monfrecola, Luca Andrea Dessy, Gabriella Fabbrocini, Matteo Megna, Giuseppe Monfrecola
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with painful nodules, abscesses, sinus tracts, and scarring primarily affecting apocrine gland-rich intertriginous areas. HS prevalence ranges from 0.05 to 1%. The central pathogenic event in HS is believed to be the occlusion of the upper part of the folliculopilosebaceous unit, leading to the rupture of the sebofollicular canal with the consequent development of perifollicular lymphohistiocytic inflammation. The HS treatment choices are influenced by disease severity and its individual subjective impact, involving both medical and surgical interventions...
May 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/28528541/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#14
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28509525/melanoma-frequency-among-symmetrical-spitzoid-looking-lesions-a-retrospective-study
#15
Claudia Costa, Matteo Megna, Milena Cappello, Maddalena Napolitano, Giuseppe Monfrecola, Massimiliano Scalvenzi
BACKGROUND: Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. METHODS: A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥ 12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking...
May 16, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28509523/skin-diseases-and-tattoos-a-five-year-experience
#16
Maddalena Napolitano, Matteo Megna, Milena Cappello, Caterina Mazzella, Cataldo Patruno
BACKGROUND: Decorative tattooing as a body art form underwent an exponential increase during the last two decades, particularly among teenagers and young adults. Consequently, the number of reported adverse reactions after tattooing has increased. The most frequent reported skin reactions to tattoo include infectious (bacterial, viral, fungal) or inflammatory (allergic contact dermatitis and granulomatous reaction) diseases. Moreover, tattoos can also induce the development of typical skin lesions of pre-existing dermatoses, a phenomenon known as isomorphism reactive or Koëbner phenomenon, which commonly occurs in patients with psoriasis, vitiligo, or lichen planus...
May 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28458570/hidradenitis-suppurativa-from-pathogenesis-to-diagnosis-and-treatment
#17
REVIEW
Maddalena Napolitano, Matteo Megna, Elena A Timoshchuk, Cataldo Patruno, Nicola Balato, Gabriella Fabbrocini, Giuseppe Monfrecola
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presenting with painful nodules, abscesses, sinus tracts, and scarring. HS is a multifactorial disease in which genetic and environmental factors play a key role. The primary defect in HS pathophysiology involves follicular occlusion of the folliculopilosebaceous unit, followed by follicular rupture, and immune responses (perifollicular lympho-histiocytic inflammation), finally leading to the development of clinical HS lesions...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28432437/an-italian-multicentre-study-on-adult-atopic-dermatitis-persistent-versus-adult-onset-disease
#18
Matteo Megna, Cataldo Patruno, Anna Balato, Franco Rongioletti, Luca Stingeni, Nicola Balato
Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease which predominantly affects children. However, AD may persist until adulthood (persistent AD), or directly start in adults (adult-onset AD). AD often shows a non-flexural rash distribution, and atypical morphologic variants in adults and specific diagnostic criteria are lacking. Moreover, adult AD prevalence as well as detailed data which can characterize persistent vs adult-onset subtype are scant. The aim of this study was to investigate on the main features of adult AD particularly highlighting differences between persistent vs adult-onset form...
August 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28399618/psoriasis-and-high-school-students-an-educational-approach
#19
Maddalena Napolitano, Matteo Megna, Cataldo Patruno, Angela Patrì, Massimiliano Scalvenzi, Giuseppe Monfrecola, Fabio Ayala, Nicola Balato
BACKGROUND: To date, no study evaluating the knowledge of psoriasis among high school students has been conducted. Thus, we aimed to examine the awareness of such disease among teenagers as well as the possible changes in both the perception of psoriasis and comprehension level after an interactive lesson. METHODS: A school-based survey was conducted in March 2016 on 300 high school students aged 14-18 years. The survey followed a three-step process. Initially, the questionnaire was administered to students in a 30 minutes period...
April 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28329612/aquagenic-wrinkling-of-the-palms-a-case-report-and-literature-review
#20
REVIEW
Matteo Megna, Mariateresa Cantelli, Donata Martellotta, Gabriella Calabrò, Anna Balato, Fabio Ayala
Aquagenic wrinkling of the palms (AWP) is an unusual and rare dermatological condition characterized by excessive palmar wrinkling, occurring within a few minutes of water exposure. Cystic fibrosis (CF) or CF carrier state associated forms, drug induced cases, and idiopathic forms have been described. We report the case of a 27-year-old woman with a 7-year history of transient excessive wrinkling of her palms after brief exposure to water. We present also a comprehensive review of the literature. We believe that AWP has been underdiagnosed thus far and we would like to encourage investigations such as sweat chloride test or genetic studies in these patients because of the association with CF or CF carrier state, particularly when AWP appears in younger ages...
September 15, 2016: Dermatology Online Journal
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