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Matteo Megna, Teresa Cirillo, Anna Balato, Nicola Balato, Lucia Gallo
Psoriasis is a chronic, inflammatory disease, often requiring long term therapy. Scalp, nails, palms, and soles have been labeled as "difficult locations" of psoriasis. Indeed, they are usually too sensitive to be treated with potent topical products for long periods, frequently necessitating systemic drugs, possibly are more resistant to therapies respect to other body sites, and tend to show recurrent disease relapse. This article is protected by copyright. All rights reserved.
June 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Joshua L Chan, Deven C Patel, Dominick Megna, Sadia J Dimbil, Ryan Levine, Jaime Moriguchi, Lawrence S Czer, Jon A Kobashigawa, Francisco Arabia, Fardad Esmailian
OBJECTIVES: Previous studies have demonstrated that preheart transplant mechanical circulatory support (MCS) can lead to a small but significant increase in mortality. However, data on outcomes of patients with MCS who require simultaneous heart-kidney transplant are limited. METHODS: A retrospective review of simultaneous heart-kidney transplantations (HKTxs) performed at a single institution over a 5-year period was performed. Patients were divided based on the preoperative use of durable MCS...
May 24, 2018: Interactive Cardiovascular and Thoracic Surgery
Annunziata Raimondo, Anna Balato, Matteo Megna, Nicola Balato
No abstract text is available yet for this article.
May 23, 2018: Expert Opinion on Biological Therapy
Matteo Megna, Pietro Gisonni, Nicola Balato
We read with great interest the letter by Kluger and we completely agree that apart from smartphone addiction also other technologies overuse such as video games joysticks and controllers may have an effect on hand joints. Particularly, we have previously demonstrated that in psoriasis patients smartphone over-use is linked with higher signs of inflammation of muscoloskelatal structures of hands joints potentially being a factor which facilitate or speed up the possible development of psoriatic arthritis (PsA)...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Nicolas Kluger
I read with great interest the article by Megna et al regarding the potential effects of smartphone addiction on the hand joints of individuals and patients with psoriasis [1]. The working hypothesis of the authors is appealing, but could fit in the broader scope of new technologies. Overuse syndrome is one of the known side effects of mobile phone and smartphone overuse, as well as video games joysticks and controllers [2,3]. Besides, the keyboard style of patients with rheumatoid arthritis may have the potential to put stress on joints that are already affected by the disease [4]...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
MichaËl Manuel, Albert Deler-hernÁndez, Yoandri S Megna, JiŘÍ HÁjek
The species of the genus Copelatus Erichson, 1832 occurring in the Dominican Republic are reviewed. Five species are recorded, with recent collecting data provided for four of them. Copelatus martini sp. nov., a member of the consors species group, is described and illustrated. It is compared to the apparently similar species C. guadelupensis Legros, 1948 based on morphological characters and on partial sequences of the CO1 gene. Interesting cases of intraspecific variability in the number of elytral dorsal striae in C...
March 21, 2018: Zootaxa
Matteo Megna, Anna Balato, Maddalena Napolitano, Lucia Gallo, Francesco Caso, Luisa Costa, Nicola Balato, Raffaele Scarpa
No abstract text is available yet for this article.
April 11, 2018: Clinical Rheumatology
Giancarlo Ianieri, Riccardo Marvulli, Giulia Alessia Gallo, Pietro Fiore, Marisa Megna
Many neurological diseases (ischemic and hemorrhagic stroke, multiple sclerosis, infant cerebral palsy, spinal cord injuries, traumatic brain injury, and other cerebrovascular disorders) may cause muscle spasticity. Different therapeutic strategies have been proposed for the treatment of spasticity. One of the major treatments for tone modulation is botulinum toxin type A (BTX-A), performed in addition to other rehabilitation strategies based on individualized multidisciplinary programs aimed at achieving certain goals for each patient...
March 28, 2018: Toxins
R Marvulli, G A Gallo, L Mastromauro, P Fiore, G Ianieri, M Megna
Goldenhar syndrome (ocular-auricular-vertebral syndrome), a rare congenital condition arising from defects in the first and second brachial arches, consists in clinical variety of features ranging from facial abnormalities, ear-eye abnormalities, vertebral defects and congenital heart problems and severe obstructive sleep apnea. Due to craniofacial abnormalities, patients presents mechanical obstructive phenomena and sialorrhea that cause prone position, language's fastening, use of nasopharyngeal cannulas and tracheal intubation...
March 28, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Freddy Caldera, Sumona Saha, Arnold Wald, Christine A Garmoe, Sue McCrone, Bryant Megna, Dana Ley, Mark Reichelderfer, Mary S Hayney
BACKGROUND: Patients with inflammatory bowel disease (IBD) are often immunosuppressed, and those patients receiving anti-tumor necrosis factor α (TNF) therapy can have lower antibody responses to vaccines. Pertussis cases are at their highest levels in the post-vaccine era. There is little data regarding responses to the Tdap (tetanus, diphtheria, and acellular pertussis) vaccine in IBD patients. AIMS: The aim of this study was to compare sustained vaccine-induced Tdap antibody concentrations in a cohort of IBD patients stratified by medication regimens with healthy controls (HC) who had received an adult Tdap booster...
June 2018: Digestive Diseases and Sciences
Luigi Barrea, Giovanna Muscogiuri, Carolina Di Somma, Giuseppe Annunziata, Matteo Megna, Andrea Falco, Anna Balato, Annamaria Colao, Silvia Savastano
Despite the wide consumption of coffee, its anti-inflammatory effect on clinical severity of psoriasis is still debatable. The aim of this study was to evaluate the association between the coffee consumption and clinical severity of psoriasis in a sample of patients stratified according to the presence of the metabolic syndrome (MetS) and smoking. This cross-sectional case-control observational study was conducted on 221 treatment-naïve psoriatic patients. Lifestyle habits, anthropometric measures, clinical and biochemical evaluations were obtained...
May 2018: Archives of Toxicology
Matteo Megna, Anna Balato, Annunziata Raimondo, Nicola Balato
Psoriasis is a chronic immune mediated disease in which the interplay of T cells and keratinocytes seems to play a key role. In this context, the interleukin (IL)-23/IL-17 axis is currently considered to be crucial in the pathogenesis of psoriasis and the selective inhibition of IL-23 may be viewed as an improvement of treatments blocking both IL-23 and IL-12, since its upstream actions. Areas covered: The authors performed a thorough and updated review on guselkumab, a fully human IgG1λ monoclonal antibody that blocks the p19 subunit of IL-23, analyzing efficacy and safety data from phase I, II and III trials...
April 2018: Expert Opinion on Biological Therapy
Maddalena Napolitano, Matteo Megna, Claudia Costa, Nicola Balato, Cataldo Patruno
No abstract text is available yet for this article.
February 6, 2018: Journal of Allergy and Clinical Immunology in Practice
Marianna Donnarumma, Matteo Megna, Maddalena Napolitano, Cataldo Patruno
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Maddalena Napolitano, Matteo Megna, Angela Patrì, Giuseppe Monfrecola, Nicola Balato
No abstract text is available yet for this article.
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Mario Starace, Carmine Minichini, Stefania De Pascalis, Margherita Macera, Laura Occhiello, Vincenzo Messina, Vincenzo Sangiovanni, Luigi E Adinolfi, Ernesto Claar, Davide Precone, Gianfranca Stornaiuolo, Maria Stanzione, Tiziana Ascione, Mara Caroprese, Rosa Zampino, Gianpaolo Parrilli, Ivan Gentile, Giuseppina Brancaccio, Vincenzo Iovinella, Salvatore Martini, Mario Masarone, Luca Fontanella, Addolorata Masiello, Evangelista Sagnelli, Rodolfo Punzi, Angelo Salomone Megna, Renato Santoro, Giovanni B Gaeta, Nicola Coppola
The study characterized the virological patterns and the resistance-associated substitutions (RASs) in patients with failure to IFN-free regimens enrolled in the real-life setting. All 87 consecutive HCV patients with failed IFN-free regimens, observed at the laboratory of the University of Campania, were enrolled. All patients had been treated with DAA regimens according to the HCV genotype, international guidelines, and local availability. Sanger sequencing of NS3, NS5A, and NS5B regions was performed at failure by home-made protocols...
May 2018: Journal of Medical Virology
Marcello Mancini, Angelo Salomone Megna, Monica Ragucci, Massimo De Luca, Giuseppina Marino Marsilia, Gerardo Nardone, Pietro Coccoli, Anna Prinster, Lorenzo Mannelli, Emilia Vergara, Serena Monti, Raffaele Liuzzi, Mariarosaria Incoronato
The presence of significant fibrosis is an indicator for liver disease staging and prognosis. The aim of the study was to determine reproducibility of real-time shear wave elastography using a hepatic biopsy as the reference standard to identify patients with chronic liver disease. Forty patients with chronic liver disease and 12 normal subjects received shear wave elastography performed by skilled operators. Interoperator reproducibility was studied in 29 patients. Fibrosis was evaluated using the Metavir score...
2017: PloS One
Maria Guarino, Raffaella Tortora, Giorgio de Stefano, Carmine Coppola, Filomena Morisco, Angelo Salomone Megna, Francesco Izzo, Gerardo Nardone, Guido Piai, Luigi Elio Adinolfi, Giuseppe D'Adamo, Giovanni Battista Gaeta, Vincenzo Messina, Giampiero Francica, Vincenzo De Girolamo, Nicola Coppola, Marcello Persico, Giovan Giuseppe Di Costanzo
BACKGROUND AND AIM: The Barcelona Clinic Liver Cancer (BCLC) algorithm is the standard system for clinical management of hepatocellular carcinoma (HCC). Data on adherence to this therapeutic paradigm are scarce. This field practice study aimed to provide a description of HCC cirrhotic patients in Southern Italy, to evaluate the adherence to BCLC guidelines and its impact on patients' survival. METHODS: We analyzed the region-wide Italian database of Progetto Epatocarcinoma Campania, which includes data of HCC cirrhotic patients, prospectively collected from January 2013 to December 2015 in 16 regional centers...
May 2018: Journal of Gastroenterology and Hepatology
M Megna, C Patruno, A Balato, M Napolitano, N Balato
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
Maddalena Napolitano, Matteo Megna, Lorenzo Squillace, Claudia Costa, Massimiliano Scalvenzi
No abstract text is available yet for this article.
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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