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https://www.readbyqxmd.com/read/29786953/iatrogenic-botulism-outbreak-in-egypt-due-to-a-counterfeit-botulinum-toxin-a-preparation-a-descriptive-series-of-patient-features-and-outcome
#1
Eman Abdel Monaem Abdel Rashid, Nashwa Mohamed El-Mahdy, Huda Shehata Kharoub, Ahmed Salah Gouda, Naglaa Ahmed ElNabarawy, Bruno Mégarbane
Iatrogenic botulism resulting from the substantial increase in use of botulinum neurotoxin type-A (BoNT-A) treatment is rarely reported. We aimed to describe a large iatrogenic botulism outbreak in Egypt in June-July 2017. Nine patients developed botulism after receiving intramuscular injections of BoNT-A (dose: 200-300 IU) to treat cerebral palsy (N=7), spastic dystonia (N=1), and hyperhidrosis (N=1). Detailed findings were available in 5/9 cases. Patients were admitted to the hospital 5-10 days after the BoNT-A injection...
May 22, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29786664/enable-2017-the-first-european-phd-and-post-doc-symposium-session-3-in-vitro-to-in-vivo-modeling-life-in-3d
#2
Gianmarco Di Mauro, Ambra Dondi, Giovanni Giangreco, Alexander Hogrebe, Elja Louer, Elisa Magistrati, Meeli Mullari, Gemma Turon, Wouter Verdurmen, Helena Xicoy Cortada, Sanja Zivanovic
The EUROPEAN ACADEMY FOR BIOMEDICAL SCIENCE (ENABLE) is an initiative funded by the European Union Horizon 2020 program involving four renowned European research institutes (Institute for Research in Biomedicine-IRB Barcelona, Spain; Radboud Institute for Molecular Life Sciences-RIMLS, the Netherlands; Novo Nordisk Foundation Center for Protein Research-NNF CPR, Denmark; European School of Molecular Medicine-SEMM, Italy) and an innovative science communication agency (Scienseed). With the aim to promote biomedical science of excellence in Europe, ENABLE organizes an annual three-day international event...
May 22, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29786511/-preeclampsia-a-challenge-also-for-cardiologists
#3
M Cournot, O Lairez, B Medzech
Due to its short-term consequences on perinatal outcome, preeclampsia has been long regarded as an obstetrical disease, strictly confined to a management by OB/GYNs. It has been now widely accepted that preeclampsia is most a systemic inflammatory and systemic vascular disease during pregnancy and then a lifelong risk factor for subsequent cardiovascular event in women's life. The aim of this review is to propose an overview in the current state-of-art in definition, early identification and management of preeclampsia...
May 18, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29785896/survey-of-trematodes-in-intertidal-snails-from-patagonia-argentina-new-larval-forms-and-diversity-assessment
#4
C Gilardoni, G Di Giorgio, E Bagnato, F Cremonte
Larval trematodes are the main parasites of snails, and they play a crucial role because they usually castrate their snail hosts and can thus alter their population and community dynamics. This study involved a survey of seven gastropod species (Crepipatella dilatata, Fissurella radiosa, Nacella magellanica, Pareuthria fuscata, Siphonaria lessonii, S. lateralis and Trophon geversianus) parasitized by 12 trematode species (one hemiurid, one gymnophallid, two lepocreadiids, two microphallids, one notocotylid, two renicolids, one philophtalmid, one schistosomatid and one zoogonid) from southern Patagonia (47°S, 65°W), Argentina...
May 22, 2018: Journal of Helminthology
https://www.readbyqxmd.com/read/29785836/facing-death-alone-or-together-investigating-the-interdependence-of-death-anxiety-dysfunctional-attitudes-and-quality-of-life-in-patient-caregiver-dyads-confronting-lung-cancer
#5
Bobo Hi-Po Lau, Daniel F K Wong, Y L Fung, Jillian Zhou, Cecilia L W Chan, Amy Y M Chow
BACKGROUND: Based on the cognitive theory, anxiety arising from the awareness of death and dying may activate dysfunctional attitudes, which may then reduce quality of life. This study examined the interdependence and the mediating role of dysfunctional attitudes on the relationship between death anxiety and quality of life among patients with lung cancer and their caregivers. METHODS: From March 2016 to April 2017, 173 pairs of patients and their caregivers enrolled in a randomized controlled trial of psychosocial support...
May 21, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29785803/depressive-spectrum-states-in-a-population-based-cohort-of-70-year-olds-followed-over-9-years
#6
Robert Sigström, Margda Waern, Pia Gudmundsson, Ingmar Skoog, Svante Östling
OBJECTIVE: Depression may be understood as a spectrum of more or less symptomatic states. Little is known about the long-term course of these states in older populations. We examined the prevalence and course of depressive states of different severity in a Swedish population sample of older people followed over 9 years. METHODS: A population-based sample of 70-year olds without dementia (N = 563, response rate 71.1%) underwent a psychiatric examination; 450 survivors without dementia were reexamined at ages 75 and/or 79 years...
May 21, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29785719/children-s-experiences-and-expectations-of-kidney-transplantation-a-qualitative-interview-study
#7
Rachael C Walker, Derisha Naicker, Tonya Kara, Suetonia C Palmer
RATIONALE AND OBJECTIVE: Kidney transplantation offers improved quality of life and life expectancy compared with dialysis for children. This study aims to understand the experiences and expectations of children during the kidney transplantation process to inform clinical care. STUDY DESIGN: Face-to-face, semi-structured interviews. SETTING AND PARTICIPANTS: We interviewed 13 children and adolescents aged between 7 and 17 years old in New Zealand who had received a kidney transplantation...
May 21, 2018: Nephrology
https://www.readbyqxmd.com/read/29785717/the-place-of-abortion-in-the-pregnancy-decision-making-process-in-young-adult-women-in-catalonia-spain
#8
Laia Ferrer Serret, Montserrat Solsona Pairó
Induced abortion is one option to control fertility in Spain. Young adult women (25-34 years old) show a different abortion pattern compared to women in other age groups, being less likely to seek abortions than younger women and having one of the lowest proportions of unintended pregnancies. We aimed to analyse the factors involved in the pregnancy decision-making process to better understand why young adult women seek abortions in Catalonia, Spain. In-depth semi-structured interviews with 25 nulliparous pregnant young adult women and one focus group discussion with healthcare providers were conducted in 2008/2010...
May 21, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29785533/stressful-life-events-adhd-symptoms-and-brain-structure-in-early-adolescence
#9
Kathryn L Humphreys, Emily L Watts, Emily L Dennis, Lucy S King, Paul M Thompson, Ian H Gotlib
Despite a growing understanding that early adversity in childhood broadly affects risk for psychopathology, the contribution of stressful life events to the development of symptoms of attention-deficit/hyperactivity disorder (ADHD) is not clear. In the present study, we examined the association between number of stressful life events experienced and ADHD symptoms, assessed using the Attention Problems subscale of the Child Behavior Checklist, in a sample of 214 children (43% male) ages 9.11-13.98 years (M = 11...
May 21, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29785278/reserve-building-activities-attenuate-treatment-burden-in-chronic-illness-the-mediating-role-of-appraisal-and-social-support
#10
Carolyn E Schwartz, Jie Zhang, Wesley Michael, David T Eton, Bruce D Rapkin
This study examines the importance of four psychosocial factors-personality, cognitive appraisal of quality of life, social support, and current reserve-building-in predicting treatment burden in chronically ill patients. Chronically ill patients ( n  = 446) completed web-based measures. Structural equation modeling was used to investigate psychosocial factors predicting treatment burden. Reserve-building activities indirectly reduced treatment burden by: (1) reducing health worries appraisals, (2) reducing financial difficulties, (3) increasing calm and peaceful appraisals, and (4) increasing perceived social support...
January 2018: Health Psychology Open
https://www.readbyqxmd.com/read/29784935/a-causal-mechanism-for-childhood-acute-lymphoblastic-leukaemia
#11
REVIEW
Mel Greaves
In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation by fusion gene formation or hyperdiploidy generates a covert, pre-leukaemic clone. Second, in a small fraction of these cases, the postnatal acquisition of secondary genetic changes (primarily V(D)J recombination-activating protein (RAG) and activation-induced cytidine deaminase (AID)-driven copy number alterations in the case of ETS translocation variant 6 (ETV6)-runt-related transcription factor 1 (RUNX1)+ ALL) drives conversion to overt leukaemia...
May 21, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29784591/accuracy-and-outcome-of-rapid-ultrasound-in-shock-and-hypotension-rush-in-egyptian-polytrauma-patients
#12
Adel Hamed Elbaih, Ahmed Mohamed Housseini, Mohamed E M Khalifa
PURPOSE: "Polytrauma" patients are of a higher risk of complications and death than the summation of expected mortality and morbidity of their individual injuries. The ideal goal in trauma resuscitation care is to identify and treat all injuries. With clinical and technological advanced imaging available for diagnosis and treatment of traumatic patients, point of care-rapid ultrasound in shock and hypotension (RUSH) significantly affects modern trauma services and patient outcomes...
March 26, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29784542/the-ovary-organization-in-the-marine-limnodriloidin-thalassodrilides-cf-briani-annelida-clitellata-naididae-resembles-the-ovary-of-freshwater-tubificins
#13
Anna Z Urbisz, Łukasz Chajec, Mana Ito, Katsutoshi Ito
In Thalassodrilides cf. briani, the paired ovaries are inconspicuous and polarized structures with developmental gradient of germ cells along their long axis. The about 300 germ cells in the ovary are consolidated into one syncytial cyst and each cell is connected to a common and branched mass of cytoplasm via one stable cytoplasmic bridge. The germ cells differentiate their fate into nurse cells and oocytes. Only one oocyte grows in a given time; it gathers cell organelles and yolk and then it detaches from the gonad...
May 12, 2018: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/29784228/the-psychometric-properties-of-the-mindful-attention-awareness-scale-among-arab-parents-of-children-with-autism-spectrum-disorder
#14
Ahmad Rayan, Muayyad Ahmad
AIM: The purpose of this study was to examine the psychometric properties and the theoretical structure of the mindful attention awareness scale (MAAS) with parents of children with autism spectrum disorder (ASD) in Jordan. METHOD: A sample of 104 parents of children with ASD in Jordan completed the study. Exploratory and confirmatory factor analyses were conducted to assess the factor structure of MAAS. Internal consistency was assessed using Cronbach's alpha. The convergent validity was assessed using Pearson's product-moment correlations between the MAAS and measures of psychological distress and Quality of life...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29784141/psychosocial-care-from-the-perspective-of-nurses-working-in-oncology-a-qualitative-study
#15
Perihan Güner, Duygu Hiçdurmaz, Nazmiye Kocaman Yıldırım, Figen İnci
PURPOSE: In cancer patients, unmet psychosocial needs are a common occurrence. The purpose of this study was to determine the views, obstacles, and needs of the nurses working with adult oncology patients with regards to psychosocial care. METHODS: A qualitative descriptive research design conducted through focus group interviews was adopted for the study. Thirty nurses providing care for cancer patients in adult oncology departments of three hospitals in Turkey with comprehensive oncology centers were involved in the interviews...
June 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29784084/perception-of-social-interaction-compresses-subjective-duration-in-an-oxytocin-dependent-manner
#16
Rui Liu, Xiangyong Yuan, Kepu Chen, Yi Jiang, Wen Zhou
Communication through body gestures permeates our daily life. Efficient perception of the message therein reflects one's social cognitive competency. Here we report that such competency is manifested temporally as shortened subjective duration of social interactions: motion sequences showing agents acting communicatively are perceived to be significantly shorter in duration as compared with those acting noncommunicatively. The strength of this effect is negatively correlated with one's autistic-like tendency...
May 22, 2018: ELife
https://www.readbyqxmd.com/read/29783983/economic-evaluation-of-a-dietary-intervention-for-adults-with-major-depression-the-smiles-trial
#17
Mary Lou Chatterton, Cathrine Mihalopoulos, Adrienne O'Neil, Catherine Itsiopoulos, Rachelle Opie, David Castle, Sarah Dash, Laima Brazionis, Michael Berk, Felice Jacka
BACKGROUND: Recently, the efficacy of dietary improvement as a therapeutic intervention for moderate to severe depression was evaluated in a randomised controlled trial. The SMILES trial demonstrated a significant improvement in Montgomery-Åsberg Depression Rating Scale scores favouring the dietary support group compared with a control group over 12 weeks. We used data collected within the trial to evaluate the cost-effectiveness of this novel intervention. METHODS: In this prospective economic evaluation, sixty-seven adults meeting DSM-IV criteria for a major depressive episode and reporting poor dietary quality were randomised to either seven sessions with a dietitian for dietary support or to an intensity matched social support (befriending) control condition...
May 22, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29783936/identifying-and-assessing-the-benefits-of-interventions-for-postnatal-depression-a-systematic-review-of-economic-evaluations
#18
Binu Gurung, Louise J Jackson, Mark Monahan, Ruth Butterworth, Tracy E Roberts
BACKGROUND: Economic evaluations of interventions for postnatal depression (PND) are essential to ensure optimal healthcare decision-making. Due to the wide-ranging effects of PND on the mother, baby and whole family, there is a need to include outcomes for all those affected and to include health and non-health outcomes for accurate estimates of cost-effectiveness. This study aimed to identify interventions to prevent or treat PND for which an economic evaluation had been conducted and to evaluate the health and non-health outcomes included...
May 21, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29783864/a-logic-model-for-pharmaceutical-care
#19
Carolina Moltó-Puigmartí, Robert Aa Vonk, Gerlise L van Ommeren, Ingrid Hegger
Objectives To develop a logic model for pharmaceutical care that can be used by stakeholders as a tool to support innovation and to monitor the performance of the pharmaceutical care system in the Netherlands and abroad. The ultimate aim of such a system is the responsible provision of drug therapy to improve patients' quality of life. Methods The logic model for pharmaceutical care was created following a process consisting of four steps: (1) a literature review to identify what pharmaceutical care is and what elements it consists of; (2) separate interviews with 10 stakeholder organizations to discuss the results of the literature review; (3) construction of the logic model based on the findings from steps 1 and 2; and (4) separate interviews with three stakeholder organizations to discuss and fine-tune the model...
January 1, 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29783779/hyperoxia-disrupts-extracellular-signal-regulated-kinases-1-2-induced-angiogenesis-in-the-developing-lungs
#20
Renuka T Menon, Amrit Kumar Shrestha, Roberto Barrios, Binoy Shivanna
Hyperoxia contributes to the pathogenesis of bronchopulmonary dysplasia (BPD), a chronic lung disease of infants that is characterized by interrupted alveologenesis. Disrupted angiogenesis inhibits alveologenesis, but the mechanisms of disrupted angiogenesis in the developing lungs are poorly understood. In pre-clinical BPD models, hyperoxia increases the expression of extracellular signal-regulated kinases (ERK) 1/2; however, its effects on the lung endothelial ERK1/2 signaling are unclear. Further, whether ERK1/2 activation promotes lung angiogenesis in infants is unknown...
May 20, 2018: International Journal of Molecular Sciences
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