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https://www.readbyqxmd.com/read/29775481/widespread-anatoxin-a-detection-in-benthic-cyanobacterial-mats-throughout-a-river-network
#1
Keith Bouma-Gregson, Raphael M Kudela, Mary E Power
Benthic algae fuel summer food webs in many sunlit rivers, and are hotspots for primary and secondary production and biogeochemical cycling. Concerningly, riverine benthic algal assemblages can become dominated by toxic cyanobacteria, threatening water quality and public health. In the Eel River in Northern California, over a dozen dog deaths have been attributed to cyanotoxin poisonings since 2000. During the summers of 2013-2015, we documented spatial and temporal patterns of cyanotoxin concentrations in the watershed, showing widespread distribution of anatoxin-a in benthic cyanobacterial mats...
2018: PloS One
https://www.readbyqxmd.com/read/29774303/myotonia-permanens-with-nav1-4-g1306e-displays-varied-phenotypes-during-course-of-life
#2
Frank Lehmann-Horn, Adele D'Amico, Enrico Bertini, Mauro Lomonaco, Luciano Merlini, Kevin R Nelson, Heike Philippi, Gabriele Siciliano, Frank Spaans, Karin Jurkat-Rott
Introduction: Myotonia permanens due to Nav1.4-G1306E is a rare sodium channelopathy with potentially life-threatening respiratory complications. Our goal was to study phenotypic variability throughout life. Methods: Clinical neurophysiology and genetic analysis were performed. Using existing functional expression data we determined the sodium window by integration. Results: In 10 unrelated patients who were believed to have epilepsy, respiratory disease or Schwartz-Jampel syndrome, we made the same prima facie diagnosis and detected the same heterologous Nav1...
September 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29774296/integrated-risk-mapping-and-landscape-characterisation-of-lymphatic-filariasis-and-loiasis-in-south-west-nigeria
#3
Tara A Brant, Patricia N Okorie, Olushola Ogunmola, Nureni Bolaji Ojeyode, S B Fatunade, Emmanuel Davies, Yisa Saka, Michelle C Stanton, David H Molyneux, J Russell Stothard, Louise A Kelly-Hope
Nigeria has the heaviest burden of lymphatic filariasis (LF) in sub-Saharan Africa, which is caused by the parasite Wuchereria bancrofti and transmitted by Anopheles mosquitoes. LF is targeted for elimination and the national programme is scaling up mass drug administration (MDA) across the country to interrupt transmission. However, in some regions the co-endemicity of the filarial parasite Loa loa (loiasis) is an impediment due to the risk of severe adverse events (SAEs) associated with the drug ivermectin...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29772886/urban-environmental-clustering-to-assess-the-spatial-dynamics-of-aedes-aegypti-breeding-sites
#4
Guillermo Albrieu-Llinás, Manuel O Espinosa, Agustín Quaglia, Marcelo Abril, Carlos Marcelo Scavuzzo
The identification of Aedes aegypti breeding hotspots in urban areas is crucial for the rational design of control strategies against this disease vector. Remote sensing and geographic information systems offer valuable tools for mapping habitat suitability of a given area. However, predicting species occurrences by means of probability distribution maps based on transversal entomological surveys has limited utility for local authorities. The aim of the present study was to carefully examine the temporal evolution of the number of houses infested with immature stages of Ae...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772884/validation-of-a-spatial-liver-fluke-model-under-field-conditions-in-ireland
#5
Amalia Naranjo Lucena, María Pía Munita Corbalán, Ana María Martínez-Ibeas, Guy McGrath, Riona Sayers, Grace Mulcahy, Annetta Zintl
Fasciola hepatica is the causative agent of fasciolosis, a global disease of a wide range of mammals, particularly sheep and cattle. Liver fluke infection causes annual losses estimated at around €2.5 billion to livestock and food industries worldwide. Various models have been developed to define risk factors and predict exposure to this liver fluke in ruminants in European countries, most of them based exclusively on data from dairy herds. The aim of this study was to validate a published theoretical baseline risk map of liver fluke exposure and cluster maps in Ireland, by including further explanatory variables and additional herd types that are spatially more widespread...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772873/prevalence-of-hypertension-in-thailand-hotspot-clustering-detected-by-spatial-analysis
#6
Wongsa Laohasiriwong, Nattapong Puttanapong, Atthawit Singsalasang
Spatial pattern detection can be a useful tool for understanding the geographical distribution of hypertension (HT). The aim of this study was to apply the technique of local indicators of spatial association statistics to examine the spatial patterns of HT in the 76 provinces of Thailand. Previous studies have demonstrated that socioeconomic status (SES), economic growth, population density and urbanization have effects on the occurrence of disease. Research has suggested that night-time light (NTL) can be used as a proxy for a number of variables, including urbanization, density, economic growth and SES...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772807/63-km-bofda-for-temperature-and-strain-monitoring
#7
Thomas Kapa, Andy Schreier, Katerina Krebber
We demonstrate (and are the first to do so) 63 km Brillouin Optical Frequency-Domain Analysis (BOFDA) for temperature and strain monitoring using a 100 km fiber loop. The use of BOFDA for long-range applications can be considered a novel approach, as previous investigations focused on the utilization of Brillouin Optical Time-Domain Reflectometry and Analysis (BOTDR and BOTDA, respectively). At 51.7 km, a 100 m hotspot (37 ∘ C) was detected without using distributed Raman amplification or image processing...
May 17, 2018: Sensors
https://www.readbyqxmd.com/read/29772452/epidemiological-aspects-of-drowning-and-non-fatal-drowning-in-the-waters-of-amsterdam
#8
G Reijnen, M van de Westeringh, M C Buster, P J E Vos, U L J Reijnders
We examined who, when, and where people non-fatally drowned of drowned in Amsterdam between January 2011 and December 2015 so that in the future more targeted and effective measures can be taken to prevent drowning. Data on non fatal drownings (N = 515, fire department database) were combined with the forensic medicine data on drowning fatalities (N=88). Who drowns in Amsterdam? The majority of those who drowned were men (82%). A high percentage of the people who drowned were under the influence of alcohol or drugs (up to 55%)...
May 8, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29771942/antisense-pmo-cocktails-effectively-skip-dystrophin-exons-45-55-in-myotubes-transdifferentiated-from-dmd-patient-fibroblasts
#9
Joshua Lee, Yusuke Echigoya, William Duddy, Takashi Saito, Yoshitsugu Aoki, Shin'ichi Takeda, Toshifumi Yokota
Antisense-mediated exon skipping has made significant progress as a therapeutic platform in recent years, especially in the case of Duchenne muscular dystrophy (DMD). Despite FDA approval of eteplirsen-the first-ever antisense drug clinically marketed for DMD-exon skipping therapy still faces the significant hurdles of limited applicability and unknown truncated protein function. In-frame exon skipping of dystrophin exons 45-55 represents a significant approach to treating DMD, as a large proportion of patients harbor mutations within this "hotspot" region...
2018: PloS One
https://www.readbyqxmd.com/read/29770936/source-identification-and-spatial-distribution-of-metals-in-soils-in-a-typical-area-of-the-lower-yellow-river-eastern-china
#10
Jianshu Lv, Yuanhe Yu
In this study, 234 soil samples were recently collected from Gaoqing County (a typical area of the lower Yellow River) to determine the contents of As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn. Multivariate statistical analyses such as correlation analysis, principal components analysis, and one-way ANOVA were applied to identify the source of metals in the soil. Geostatistical methods were used to analyze the spatial structure and distribution of the metals. The results indicated that the mean contents of all metals exceeded the background value of the lower Yellow River, especially for As, Cu, and Hg (1...
May 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29768879/a-novel-assay-coupling-dephosphorylation-and-blue-white-colony-screening-for-the-g-a-hotspot-mutation-at-codon-13-of-kras-gene
#11
Cuilan Zhou, Wangyang Pu, Yu-Fang Yin, Li Xiao, Dixian Luo, Fenjiao Wang, Cuiying Peng, Zifen Guo, Xuan Liu, Huifen Xu, Chungen Xing, Nongyue He, Wanping Sun, Weijun Cai, Duanfang Liao, Kai Li
Development of sensitive assay for detection of hotspot mutations of cancer driving gene is crucial for circulating tumor DNA analysis. This study tested the possibilities of applying restriction enzyme digestion and dephosphorylation coupled with blue/white screening technology for analyzing a hotspot point mutation in codon 13 of KRAS gene. The present study has documented that the combination of PCR with restriction digestion, dephosphorylation, blue/white screening and Sanger's sequencing can identify rare mutations with sensitivities at 0...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768453/spatiotemporal-characteristics-of-elderly-population-s-traffic-accidents-in-seoul-using-space-time-cube-and-space-time-kernel-density-estimation
#12
Youngok Kang, Nahye Cho, Serin Son
The purpose of this study is to analyze how the spatiotemporal characteristics of traffic accidents involving the elderly population in Seoul are changing by time period. We applied kernel density estimation and hotspot analyses to analyze the spatial characteristics of elderly people's traffic accidents, and the space-time cube, emerging hotspot, and space-time kernel density estimation analyses to analyze the spatiotemporal characteristics. In addition, we analyzed elderly people's traffic accidents by dividing cases into those in which the drivers were elderly people and those in which elderly people were victims of traffic accidents, and used the traffic accidents data in Seoul for 2013 for analysis...
2018: PloS One
https://www.readbyqxmd.com/read/29767798/genome-wide-association-of-yield-traits-in-a-nested-association-mapping-population-of-barley-reveals-new-gene-diversity-for-future-breeding
#13
Rajiv Sharma, Fulvia Draicchio, Hazel Bull, Paul Herzig, Andreas Maurer, Klaus Pillen, William T B Thomas, Andrew J Flavell
To explore wild barley as a source of useful alleles for yield improvement in breeding we have carried out a genome-wide association scan using the nested association mapping population HEB-25, which contains 25 diverse exotic barley genomes superimposed on a ca 70% genetic background of cultivated barley. 1420 HEB-25 lines were trialled for nine yield-related grain traits for two years in Germany and Scotland, with varying N-fertilizer application. The phenotypic data were related to genotype scores for 5,398 gene-based SNP markers...
May 15, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29765957/genetic-insights-into-frailty-association-of-9p21-23-locus-with-frailty
#14
Sanish Sathyan, Nir Barzilai, Gil Atzmon, Sofiya Milman, Emmeline Ayers, Joe Verghese
Frailty is a complex aging phenotype associated with increased vulnerability to disability and death. Understanding the biological antecedents of frailty may provide clues to healthy aging. The genome-wide association study hotspot, 9p21-23 region, is a risk locus for a number of age-related complex disorders associated with frailty. Hence, we conducted an association study to examine whether variations in 9p21-23 locus plays a role in the pathogenesis of frailty in 637 community-dwelling Ashkenazi Jewish adults aged 65 and older enrolled in the LonGenity study...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29765380/the-complete-plastome-sequences-of-seven-species-in-gentiana-sect-kudoa-gentianaceae-insights-into-plastid-gene-loss-and-molecular-evolution
#15
Shan-Shan Sun, Peng-Cheng Fu, Xiao-Jun Zhou, Yan-Wei Cheng, Fa-Qi Zhang, Shi-Long Chen, Qing-Bo Gao
The chloroplast (cp) genome is useful in the study of phylogenomics, molecular dating, and molecular evolution. Gentiana sect. Kudoa is a predominantly alpine flowering plant that is valued for its contributions to medicine, ecology, and horticulture. Previous evolutionary studies showed that the plastid gene loss pattern and intra-sectional phylogenetics in sect. Kudoa are still unclear. In this study, we compared 11 Gentiana plastomes, including 7 newly sequenced plastomes from sect. Kudoa , to represent its three serious: ser...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29765085/submarine-canyons-represent-an-essential-habitat-network-for-krill-hotspots-in-a-large-marine-ecosystem
#16
Jarrod A Santora, Ramona Zeno, Jeffrey G Dorman, William J Sydeman
Submarine canyon systems are ubiquitous features of marine ecosystems, known to support high levels of biodiversity. Canyons may be important to benthic-pelagic ecosystem coupling, but their role in concentrating plankton and structuring pelagic communities is not well known. We hypothesize that at the scale of a large marine ecosystem, canyons provide a critical habitat network, which maintain energy flow and trophic interactions. We evaluate canyon characteristics relative to the distribution and abundance of krill, critically important prey in the California Current Ecosystem...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29763867/shiga-toxigenic-escherichia-coli-incidence-is-related-to-small-area-variation-in-cattle-density-in-a-region-in-ireland
#17
C Brehony, J Cullinan, M Cormican, D Morris
Shiga toxigenic Escherichia coli (STEC) are pathogenic E. coli that cause infectious diarrhoea. In some cases infection may be complicated by renal failure and death. The incidence of human infection with STEC in Ireland is the highest in Europe. The objective of the study was to examine the spatial incidence of human STEC infection in a region of Ireland with significantly higher rates of STEC incidence than the national average and to identify possible risk factors of STEC incidence at area level. Anonymised laboratory records (n = 379) from 2009 to 2015 were obtained from laboratories serving three counties in the West of Ireland...
May 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29762585/unexpected-large-nanoparticle-size-of-single-dimer-hotspot-systems-for-broadband-sers-enhancement
#18
Yu Huang, Yun Chen, Xiaotian Xue, Yanni Zhai, Lingling Wang, Zhengjun Zhang
We have numerically demonstrated the feasibility and possibility to achieve broadband surface-enhanced Raman scattering (SERS) enhancement in the visible and near-infrared wavelength range using single nanoparticle (NP) dimer hotspot systems. Instead of the conventionally reported sub-100 nm, we find that the optimal NP size is as large as 200 nm in diameter for both Ag and Au. The key lies in the continuous arising of the bonding dipole plasmon mode and higher-order resonances at shorter wavelengths. Further, it is revealed that the near- and far-field optical responses of these hotspot systems correlate well with each other, despite the intrinsic enormous near- to far-field redshift for individual large NPs...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29761859/systematic-analyses-of-a-novel-lncrna-associated-signature-as-the-prognostic-biomarker-for-hepatocellular-carcinoma
#19
Jing Sui, Yan Miao, Jiali Han, Hongmei Nan, Bo Shen, Xiaomei Zhang, Yan Zhang, Yuan Wu, Wenjuan Wu, Tong Liu, Siyi Xu, Sheng Yang, Lihong Yin, Yuepu Pu, Geyu Liang
Accumulating evidence implies that long noncoding RNAs (lncRNAs) play a crucial role in predicting survival for Hepatocellular carcinoma (HCC) patients. This study aims to capture the current research hotspots of HCC, based on the analysis of publications related to HCC research from 2013 to 2017, and to identify a novel lncRNA signature for HCC prognosis through the data mining in The Cancer Genome Atlas (TCGA). "Prognosis" and "biomarker" were located in the core of the HCC research hotspot...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29760118/icebergs-sea-ice-blue-carbon-and-antarctic-climate-feedbacks
#20
David K A Barnes, Andrew Fleming, Chester J Sands, Maria Liliana Quartino, Dolores Deregibus
Sea ice, including icebergs, has a complex relationship with the carbon held within animals (blue carbon) in the polar regions. Sea-ice losses around West Antarctica's continental shelf generate longer phytoplankton blooms but also make it a hotspot for coastal iceberg disturbance. This matters because in polar regions ice scour limits blue carbon storage ecosystem services, which work as a powerful negative feedback on climate change (less sea ice increases phytoplankton blooms, benthic growth, seabed carbon and sequestration)...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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