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https://www.readbyqxmd.com/read/27864477/is-visceral-flow-during-intra-aortic-balloon-pumping-size-or-volume-dependent
#1
Sandro Gelsomino, Pieter W J Lozekoot, Monique M J de Jong, Fabiana Lucà, Orlando Parise, Francesco Matteucci, Mario Romano, Abdullrazak Hossien, Mark La Meir, Niccolò Marchionni, Jos G Maessen, Roberto Lorusso
AIM: We evaluated the influence of intra-aortic balloon size and volume on mesenteric and renal flows. METHODS: Thirty healthy swine underwent 120-minute ligation of the left anterior descending coronary artery followed by 6 hours of reperfusion. Then, they were randomly assigned to the following five groups of animals, with six animals in each group: no intra-aortic balloon pump (IABP), a short 35-mL IABP, a short 40-mL IABP, a long 35-mL IABP and a long 40-mL IABP...
November 17, 2016: Perfusion
https://www.readbyqxmd.com/read/27821578/regulatory-b-cells-induce-formation-of-il-10-expressing-t-cells-in-mice-with-autoimmune-neuroinflammation
#2
Andrea Pennati, Spencer Ng, Yuanqiang Wu, Jordan R Murphy, Jiusheng Deng, Srikant Rangaraju, Seneshaw Asress, Jennifer L Blanchfield, Brian Evavold, Jacques Galipeau
: Although B cells are traditionally known for their role in propagating pro-inflammatory immune responses, their immunosuppressive effects have only begun to be recently appreciated. How these regulatory B cells (Bregs) suppress the immune response remains to be worked out in detail. In this paper we show that Bregs can induce formation of conventional FoxP3(+) regulatory T cells (Tregs), as well as a more recently described CD49b(+)CD223(+) regulatory T cell subset, known as type 1 regulatory T cells (Tr1)...
November 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27787789/basic-aspects-of-t-helper-cell-differentiation
#3
Nicola Gagliani, Samuel Huber
CD4+ T helper cells orchestrate the immune response and play a pivotal role during infection, chronic inflammatory, autoimmune diseases, and carcinogenesis. CD4+ T helper cells can be subdivided into different subsets, which are characterized by a specific network of transcriptional regulators and unique cytokine profiles: Th17 cells express RORγt that in turn promotes the transcription of Il17a, Il17f; Th1 cells, expresses T-bet and produces IFN-γ, IL-2, and TNF-α; Th2 cells express GATA-3 and secrete IL-4, IL-5, and IL-13...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27734414/regulation-and-immune-function-of-il-27
#4
Qinghong Wang, Jianguo Liu
IL-27 is a pleiotropic cytokine that has diverse immune regulatory activities under both physiological and pathological conditions. IL-27 enhances the functions of Th1 and CD8(+) T cells, promotes the development of Tfh and Tr1, and suppresses the functions of Th2, Treg, Th9, and Th17 cells. IL-27 is also involved in regulation of immune responses of B cells, NK, DCs, and macrophages. IL-27 production is strictly regulated at both transcriptional and posttranscriptional levels. Given its broad effects on immune regulation, IL-27 has been implicated in the pathogeneses of autoimmune and infectious diseases as well as cancers...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27708643/differential-regulation-of-self-reactive-cd4-t-cells-in-cervical-lymph-nodes-and-central-nervous-system-during-viral-encephalomyelitis
#5
Carine Savarin, Cornelia C Bergmann, David R Hinton, Stephen A Stohlman
Viral infections have long been implicated as triggers of autoimmune diseases, including multiple sclerosis (MS), a central nervous system (CNS) inflammatory demyelinating disorder. Epitope spreading, molecular mimicry, cryptic antigen, and bystander activation have been implicated as mechanisms responsible for activating self-reactive (SR) immune cells, ultimately leading to organ-specific autoimmune disease. Taking advantage of coronavirus JHM strain of mouse hepatitis virus (JHMV)-induced demyelination, this study demonstrates that the host also mounts counteractive measures to specifically limit expansion of endogenous SR T cells...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27705789/type-i-interferons-regulate-immune-responses-in-humans-with-blood-stage-plasmodium-falciparum-infection
#6
Marcela Montes de Oca, Rajiv Kumar, Fabian de Labastida Rivera, Fiona H Amante, Meru Sheel, Rebecca J Faleiro, Patrick T Bunn, Shannon E Best, Lynette Beattie, Susanna S Ng, Chelsea L Edwards, Glen M Boyle, Ric N Price, Nicholas M Anstey, Jessica R Loughland, Julie Burel, Denise L Doolan, Ashraful Haque, James S McCarthy, Christian R Engwerda
The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4(+) T cell IFNγ production, and they promoted the development of parasitic-specific IL-10-producing Th1 (Tr1) cells...
October 4, 2016: Cell Reports
https://www.readbyqxmd.com/read/27704876/cd4-foxp3-il-10-tr1-cells-promote-relapse-of-diffuse-large-b-cell-lymphoma-by-enhancing-the-survival-of-malignant-b-cells-and-suppressing-antitumor-t-cell-immunity
#7
Guozhen Liu, Jing Luan, Qiang Li
Diffuse large B cell lymphoma (DLBCL) is a common B cell malignancy. Complete remission can be achieved in most patients by conventional treatment with rituximab and chemotherapy. However, a subset of remission individuals will develop a relapsed disease for obscure reasons. CD4(+)Foxp3(-)IL-10(+) cell (Tr1) is a novel cell subtype with the capacity to suppress pro-inflammatory responses, but has not been extensively studied in most tumors. In this study, we investigated the potential role of Tr1 cells in DLBCL...
October 5, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27697703/dynamics-of-cytokine-mrna-expression-and-fecal-biomarkers-in-school-children-undergoing-a-double-blind-placebo-controlled-food-challenge-series
#8
Anna Winberg, Olga Nagaeva, Ivan Nagaev, Catarina Lundell, Ignacio Arencibia, Lucia Mincheva-Nilsson, Eva Rönmark, Christina E West
BACKGROUND: There is need for prognostic markers for symptomatic food allergy since current diagnostic methods are insufficient and/or time and labor consuming. OBJECTIVE: To estimate the cytokine mRNA profiles in peripheral blood mononuclear cells (PBMC) before and after a double-blind placebo-controlled food challenge series in schoolchildren with suspected allergy to milk, egg or cod and in healthy controls. Analyses of fecal inflammatory biomarkers before and after the challenge were included...
December 2016: Cytokine
https://www.readbyqxmd.com/read/27683580/tr1-like-t-cells-an-enigmatic-regulatory-t-cell-lineage
#9
Anna Malgorzata White, David C Wraith
The immune system evolved to respond to foreign invaders and prevent autoimmunity to self-antigens. Several types of regulatory T cells facilitate the latter process. These include a subset of Foxp3(-) CD4(+) T cells able to secrete IL-10 in an antigen-specific manner, type 1 regulatory (Tr1) T cells. Although their suppressive function has been confirmed both in vitro and in vivo, their phenotype remains poorly defined. It has been suggested that the surface markers LAG-3 and CD49b are biomarkers for murine and human Tr1 cells...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27644153/cd4-foxp3-type-1-regulatory-t-cells-in-glioblastoma-multiforme-suppress-t-cell-responses-through-multiple-pathways-and-are-regulated-by-tumor-associated-macrophages
#10
Zhao Li, Xiaobing Liu, Rongbin Guo, Pengfei Wang
CD4(+)Foxp3(-) type 1 regulatory T (Tr1) cells are potent producers of interleukin 10 (IL-10) and transforming growth factor beta (TGF-β), through which they suppress pathogenic inflammation and autoimmune responses. The role of Tr1 response in glioblastoma multiforme (GBM) is still unclear. Here, we examined the frequency, phenotype, induction mechanism, and function of Tr1 cells in GBM patients. Compared to healthy controls, GBM patients presented significantly higher frequency of Tr1 cells in peripheral blood...
September 16, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27611240/cloning-and-characterization-of-tambd6-homeologues-encoding-methyl-cpg-binding-domain-proteins-in-wheat
#11
Ruijie Shi, Jiahui Zhang, Jingyuan Li, Ketao Wang, Haiying Jia, Lin Zhang, Putong Wang, Jun Yin, Fanrong Meng, Yongchun Li
DNA methylation is a major epigenetic marker in plants that plays a crucial role in transcriptional and developmental regulation. The DNA methylation 'code' is thought to be 'read' by a set of proteins containing methyl-CpG-binding domain (MBD). However, little is known about MBD genes in common wheat (Triticum aestivum L.). Here, we report the isolation and characterization of TaMBD6 and its homeologues (TaMBD6_A, TaMBD6_B, and TaMBD6_D) in hexaploid wheat. The cDNA was quite different among the three homeologues and InDel mutations were detected in 5'-UTR and coding region...
September 1, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27581189/novel-foxp3-il-10-regulatory-t-cells-induced-by-b-cells-alleviate-intestinal-inflammation-in-vivo
#12
Tzu-Yu Shao, Ling-Hui Hsu, Chien-Hui Chien, Bor-Luen Chiang
Recent studies have revealed various Foxp3(-) regulatory T (Treg) cell subsets effectively protect mice from colitis. In the present study, we demonstrated that B cells induced a particular subset of regulatory T (Treg-of-B) cells, expressing programmed cell death 1 (PD-1), inducible costimulator (ICOS), lymphocyte-activation gene 3 (LAG3), glucocorticoid-induced tumor necrosis factor receptor (GITR), and OX-40, did not express Foxp3. Treg-of-B cells produced abundant levels of IL-10 and low levels of IL-4 and TGF-β...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27579860/macrophage-mediated-gliadin-degradation-and-concomitant-il-27-production-drive-il-10-and-ifn-%C3%AE-secreting-tr1-like-cell-differentiation-in-a-murine-model-for-gluten-tolerance
#13
M A van Leeuwen, L M M Costes, L A van Berkel, Y Simons-Oosterhuis, M F du Pré, A E Kozijn, H C Raatgeep, D J Lindenbergh-Kortleve, N van Rooijen, F Koning, J N Samsom
Celiac disease is caused by inflammatory T-cell responses against the insoluble dietary protein gliadin. We have shown that, in humanized mice, oral tolerance to deamidated chymotrypsin-digested gliadin (CT-TG2-gliadin) is driven by tolerogenic interferon (IFN)-γ- and interleukin (IL)-10-secreting type 1 regulatory T-like cells (Tr1-like cells) generated in the spleen but not in the mesenteric lymph nodes. We aimed to uncover the mechanisms underlying gliadin-specific Tr1-like-cell differentiation and hypothesized that proteolytic gliadin degradation by splenic macrophages is a decisive step in this process...
August 31, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27576321/assessment-of-the-effects-of-rituximab-monotherapy-on-different-subsets-of-circulating-t-regulatory-cells-and-clinical-disease-severity-in-severe-pemphigus-vulgaris
#14
Rajsmita Bhattacharjee, Dipankar De, Sanjeev Handa, Ranjana W Minz, Biman Saikia, Neha Joshi
BACKGROUND: Robust evidence for the efficacy of rituximab monotherapy in pemphigus is lacking. The effects of rituximab on T-regulatory cells (Tregs) in pemphigus have not been studied. OBJECTIVE: The primary objective was to assess the efficacy of rituximab monotherapy in severe pemphigus vulgaris. The secondary objectives were to assess whether counts of different subsets of Tregs in the peripheral blood correlate with baseline clinical severity and whether clinical response in severe pemphigus is associated with an alteration in the Treg count...
September 1, 2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/27561251/anti-inflammatory-effects-of-melatonin-in-multiple-sclerosis
#15
Mauricio F Farez, Ismael L Calandri, Jorge Correale, Francisco J Quintana
Melatonin is a hormone with complex roles in the pathogenesis of autoimmune disorders. Over the years, it has become clear that melatonin may exacerbate some autoimmune conditions, whereas it alleviates others such as multiple sclerosis. Multiple sclerosis is an autoimmune disorder characterized by a dysregulated immune response directed against the central nervous system. Indeed, the balance between pathogenic CD4(+) T cells secreting IFN-γ (TH 1) or IL-17 (TH 17); and FoxP3(+) regulatory T cells and IL-10(+) type 1 regulatory T cells (Tr1 cells) is thought to play an important role in disease activity...
October 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/27558304/inhibition-of-cd8-t-cells-and-elimination-of-myeloid-cells-by-cd4-%C3%A2-foxp3-t-regulatory-type-1-cells-in-acute-respiratory-distress-syndrome
#16
Guang-Gang Li, Ying-Hua Cao, Yue Run, Ru-Xiang Xu, Zhen-Dong Zheng
Acute lung injury and acute respiratory distress syndrome (ARDS) are caused by rapid-onset bilateral pulmonary inflammation. We therefore investigated the potential role of interleukin (IL)-10(+) CD4(+) Tr1 cells, a regulatory T cell subset with previously identified immunosuppressive functions, in ARDS patients. We first showed that circulating Tr1 cells were upregulated in active and resolved ARDS patients compared to healthy controls and pneumonia patient controls. A significant fraction of these Tr1 cells expressed granzyme B and perforin, while most Tr1 cells did not express interferon gamma (IFN-γ), IL-4, IL-17 or FOXP3, suggesting that the effector functions of these Tr1 cells were primarily mediated by IL-10, granzyme B, and perforin...
December 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27508309/inoculation-of-brassica-oxyrrhina-with-plant-growth-promoting-bacteria-for-the-improvement-of-heavy-metal-phytoremediation-under-drought-conditions
#17
Ying Ma, Mani Rajkumar, Chang Zhang, Helena Freitas
The aim of this study was to investigate the effects of drought resistant serpentine rhizobacteria on plant growth and metal uptake by Brassica oxyrrhina under drought stress (DS) condition. Two drought resistant serpentine rhizobacterial strains namely Pseudomonas libanensis TR1 and Pseudomonas reactans Ph3R3 were selected based on their ability to stimulate seedling growth in roll towel assay. Further assessment on plant growth promoting (PGP) parameters revealed their ability to produce indole-3-acetic acid, siderophore and 1-aminocyclopropane-1-carboxylate deaminase...
December 15, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27470891/-preventive-and-therapeutic-effects-of-rapamycin-against-autoimmune-hepatitis-and-liver-fibrosis-and-possible-mechanisms
#18
W W Li, P Sun, D D Chen, W Q Wang, G H Jiao, Y J Wang, L Zhou, B M Wang, J Zhang
OBJECTIVE: To investigate the preventive and therapeutic effects of rapamycin (RAPA) on autoimmune hepatitis and liver fibrosis induced by concanavalin A (ConA) and possible mechanisms. METHODS: Female C57BL/6 mice aged 8 weeks were randomly divided into normal control group, ConA model group, and ConA+RAPA treatment group. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured; hematoxylin-eosin and Masson staining and Knodell HAI and Ishak scoring systems were used to evaluate the degrees of liver inflammation and fibrosis...
May 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27467950/trail-receptor-1-igm-antibodies-strongly-induce-apoptosis-in-human-cancer-cells-in-vitro-and-in-vivo
#19
Xiuhong Piao, Tatsuhiko Ozawa, Hiroshi Hamana, Kiyomi Shitaoka, Aishun Jin, Hiroyuki Kishi, Atsushi Muraguchi
Agonistic tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-receptor-specific antibodies are attractive antitumor therapeutics. Recently, our group has generated several human monoclonal antibodies (mAbs) to TRAIL-receptor-1 (TRAIL-R1) (TR1-IgGs) using ISAAC technology. However, these TR1-IgGs did not demonstrate ideal apoptosis-inducing capacity in the absence of additional antibodies. To overcome this limitation, we class-switched the TR1-IgGs to TRAIL-R1 IgM antibodies (TR1-IgMs); TR1-IgMs might possess high valency and facilitate the crosslinking of the cell surface receptors...
May 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27358131/psychological-stress-moderates-the-relationship-between-running-volume-and-cd4-t-cell-subpopulations
#20
K E Rehm, I Sunesara, M T Tull, G D Marshall
Endurance-based exercise training can lead to alterations in components of the immune system, but it is unknown how psychological stress (another potent immunomodulator) may impact these changes. The purpose of this study was to determine the moderating role of psychological stress on exercise-induced immune changes. Twenty-nine recreational runners were recruited for this study four weeks before completing a marathon. Each subject reported: weekly training volume (miles/wk) for the week prior to the study visit; completed the Perceived Stress Scale (PSS), the state version of the State-Trait Anxiety Inventory (STAI) and the Penn State Worry Questionnaire (PSWQ); and donated blood for assessment of CD4+ T cell subpopulations and mitogen-induced cytokine production...
April 2016: Journal of Biological Regulators and Homeostatic Agents
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