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https://www.readbyqxmd.com/read/28733878/role-of-tgf-%C3%AE-in-self-peptide-regulation-of-autoimmunity
#1
REVIEW
Bhagirath Singh, Michael D Krawetz, Rachel M De Lima, Rinee Mukherjee, Pratibha Chaturvedi, Edwin Lee-Chan, Edward H Leiter, Kelly L Summers
Transforming growth factor (TGF)-β has been implicated in regulation of the immune system, including autoimmunity. We have found that TGF-β is readily produced by T cells following immunization with self-peptide epitopes that downregulate autoimmune responses in type 1 diabetes (T1D) prone nonobese diabetic (NOD) mice. These include multiple peptide epitopes derived from the islet β-cell antigens GAD65 (GAD65 p202-221, GAD65 p217-236), GAD67 (GAD67 p210-229, GAD67 p225-244), IGRP (IGRP p123-145, IGRP p195-214) and insulin B-chain (Ins...
July 21, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28700515/mechanical-metabolic-and-perceptual-acute-responses-to-different-set-configurations-in-full-squat
#2
J M González-Hernádez, A García-Ramos, F Capelo-Ramírez, A Castaño-Zambudio, G Marquez, D Boullosa, P Jiménez-Reyes
This study aimed to compare mechanical, metabolic, and perceptual responses between two traditional (TR) and four cluster (CL) set configurations. In a counterbalanced randomized order, 11 men were tested with the following protocols in separate sessions (sets × repetitions [inter-repetition rest]): TR1: 3×10 [0-s]; TR2: 6×5 [0-s]; CL1: 3×10 [10-s]; CL2: 3×10 [15-s]; CL3: 3×10 [30-s]); CL4: 1×30 [15-s]). The exercise (full-squat), number of repetitions (30), inter-set rest (5 min), and resistance applied (10RM) was the same for all set configurations...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28690330/irf1-and-batf-transcription-factors-that-set-the-epigenetic-landscape-for-tr1-cell-differentiation
#3
Katarina Stanko, Birgit Sawitzki
No abstract text is available yet for this article.
July 10, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28689791/peanut-specific-tr1-cells-induced-in-vitro-from-allergic-individuals-are-functionally-impaired
#4
Laurence Pellerin, Jennifer Anne Jenks, Sharon Chinthrajah, Tina Dominguez, Whitney Block, Xiaoying Zhou, Arram Noshirvan, Silvia Gregori, Maria Grazia Roncarolo, Kari Christine Nadeau, Rosa Bacchetta
BACKGROUND: Peanut allergy is a life threatening condition which lacks regulatory-approved treatment. T regulatory type 1 (Tr1) cells are potent suppressors of immune responses and can be induced in vivo upon repeated antigen exposure or in vitro using tolerogenic dendritic cells (DC-10). Whether or not oral immunotherapy (OIT) leads to antigen-specific Tr1 cell induction has not been established. OBJECTIVES: To determine whether peanut-specific Tr1 cells can be generated in vitro from peripheral blood of peanut allergic (PA) individuals at baseline or during OIT, and whether they are functional as compared to peanut-specific Tr1 cells induced from healthy controls (HC)...
July 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28685820/pi3k-akt-pathway-enhances-the-differentiation-of-il-27-induced-type-1-regulatory-t-cells
#5
Niken Adiba Nadya, Hiroyuki Tezuka, Toshiaki Ohteki, Satoshi Matsuda, Miyuki Azuma, Shigenori Nagai
Interleukin 27 (IL-27) has been identified as a potent cytokine in the differentiation of type 1 regulatory T (Tr1) cells through interactions with several key elements, including transcription factors such as aryl hydrocarbon receptor and IL-21. Autocrine production of IL-21 is known to be important for maintaining IL-10 expression by Tr1 cells. Although previous studies have shown that the PI3K-Akt axis contributes to the differentiation of helper T cell subsets, the role of the PI3K pathway on Tr1 cell differentiation remains to be elucidated...
July 6, 2017: Immunology
https://www.readbyqxmd.com/read/28668505/regulation-of-allergic-airway-inflammation-by-adoptive-transfer-of-cd4-t-cells-preferentially-producing-il-10
#6
Masaya Matsuda, Kana Doi, Tatsuya Tsutsumi, Shinya Fujii, Maki Kishima, Kazuma Nishimura, Ikue Kuroda, Yu Tanahashi, Rino Yuasa, Toshihiko Kinjo, Nobuyuki Kuramoto, Nobuaki Mizutani, Takeshi Nabe
Anti-inflammatory pharmacotherapy for asthma has mainly depended on the inhalation of glucocorticoids, which non-specifically suppress immune responses. If the anti-inflammatory cytokine interleukin (IL)-10 can be induced by a specific antigen, asthmatic airway inflammation could be suppressed when individuals are exposed to the antigen. The purpose of this study was to develop cellular immunotherapeutics for atopic diseases using IL-10-producing CD4(+) T cells. Spleen cells isolated from ovalbumin (OVA)-sensitized mice were cultured with the antigen, OVA and growth factors, IL-21, IL-27 and TGF-β for 7 days...
June 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28651594/the-cd4-t-cell-regulatory-network-mediates-inflammatory-responses-during-acute-hyperinsulinemia-a-simulation-study
#7
Mariana E Martinez-Sanchez, Marcia Hiriart, Elena R Alvarez-Buylla
BACKGROUND: Obesity is frequently linked to insulin resistance, high insulin levels, chronic inflammation, and alterations in the behaviour of CD4+ T cells. Despite the biomedical importance of this condition, the system-level mechanisms that alter CD4+ T cell differentiation and plasticity are not well understood. RESULTS: We model how hyperinsulinemia alters the dynamics of the CD4+ T regulatory network, and this, in turn, modulates cell differentiation and plasticity...
June 26, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28647182/preoperative-application-of-combination-of-portal-venous-injection-of-donor-spleen-cells-and-intraperitoneal-injection-of-rapamycin-prolongs-the-survival-of-cardiac-allografts-in-mice
#8
Wen-Lin Gong, Chuang Sha, Gang Du, Zhong-Gui Shan, Zhong-Quan Qi, Su-Fang Zhou, Nuo Yang, Yong-Xiang Zhao
OBJECTIVE: To investigate the effects of preoperative portal venous injection of donor spleen cells (PVIDSC) and intraperitoneal injection of rapamycin in the acute rejection of cardiac allograft in mice and the underlying mechanisms. METHODS: Homogenous female B6 mice and BALB/c mice were used as recipients and donors of heart transplantation. These mice were randomly divided into different groups and received PVIDSC alone, rapamycin alone, or PVIDSC and rapamycin combined therapy...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28635957/itk-signalling-via-the-ras-irf4-pathway-regulates-the-development-and-function-of-tr1-cells
#9
Weishan Huang, Sabrina Solouki, Nicholas Koylass, Song-Guo Zheng, Avery August
Type 1 regulatory T (Tr1) cells differentiate in response to signals engaging the T cell receptor (TCR), express high levels of the immunosuppressive cytokine IL-10, but not Foxp3, and can suppress inflammation and promote immune tolerance. Here we show that ITK, an important modulator of TCR signalling, is required for the TCR-induced development of Tr1 cells in various organs, and in the mucosal system during parasitic and viral infections. ITK kinase activity is required for mouse and human Tr1 cell differentiation...
June 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28629093/novel-pemulen-pullulan-blended-hydrogel-containing-clotrimazole-loaded-cationic-nanocapsules-evaluation-of-mucoadhesion-and-vaginal-permeation
#10
Julia A de Lima, Thamiris C Paines, Mariana H Motta, Watussi B Weber, Sara S Dos Santos, Letícia Cruz, Cristiane de B da Silva
In this work, hydrogels containing clotrimazole-loaded nanocapsules were developed through the innovative association of two mucoadhesive polymers: Pemulen® TR1 and Pullulan. Furthermore, the hydrogels macroscopic characteristics, pH and spreadability were evaluated. The formulations showed homogeneous appearance and pH compatible with vaginal application (around 5.0). Similar spreadability profiles were found in hydrogels containing clotrimazole-loaded nanocapsules and in the free drug as well. Hydrogels were evaluated considering their mucoadhesive potential by the falling liquid film method and the permeation/penetration capacity through cow vaginal mucosa in Franz cell...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28604806/prostaglandin-e2-inhibits-tr1-cell-differentiation-through-suppression-of-c-maf
#11
Kirsten Mary Hooper, Weimin Kong, Doina Ganea
Prostaglandin E2 (PGE2), a major lipid mediator abundant at inflammatory sites, acts as a proinflammatory agent in models of inflammatory/autoimmune diseases by promoting CD4 Th1/Th17 differentiation. Regulatory T cells, including the IL-10 producing Tr1 cells counterbalance the proinflammatory activity of effector Th1/Th17 cells. Tr1 cell differentiation and function are induced by IL-27, and depend primarily on sustained expression of c-Maf in addition to AhR and Blimp-1. In agreement with the in vivo proinflammatory role of PGE2, here we report for the first time that PGE2 inhibits IL-27-induced differentiation and IL-10 production of murine CD4+CD49b+LAG-3+Foxp3- Tr1 cells...
2017: PloS One
https://www.readbyqxmd.com/read/28599652/regulatory-t-cells-in-multiple-sclerosis-and-myasthenia-gravis
#12
REVIEW
K M Danikowski, S Jayaraman, B S Prabhakar
Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically susceptible individuals. On the other hand, myasthenia gravis (MG) primarily involves destruction of the neuromuscular junction by antibodies specific to the acetylcholine receptor. Both autoimmune diseases are thought to result from loss of self-tolerance, which allows for the development and function of autoreactive lymphocytes. Although the mechanisms underlying compromised self-tolerance in these and other autoimmune diseases have not been fully elucidated, one possibility is numerical, functional, and/or migratory deficits in T regulatory cells (Tregs)...
June 9, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28597951/treg-conditioning-endows-activated-teff-with-suppressor-function-in-autoimmune-hepatitis-autoimmune-sclerosing-cholangitis
#13
Rodrigo Liberal, Charlotte R Grant, Muhammed Yuksel, Jonathon Graham, Alireza Kalbasi, Yun Ma, Michael A Heneghan, Giorgina Mieli-Vergani, Diego Vergani, Maria Serena Longhi
Imbalance between T regulatory (Treg) and T effector (Teff) cells is likely to contribute to induction and perpetuation of liver damage in autoimmune hepatitis (AIH) and autoimmune sclerosing cholangitis (AISC) either through inability of Tregs to restrain proliferation and effector cytokine production by responders or through conversion of Tregs into T helper type 1 (Th1) or type 17 (Th17) effector lymphocytes. We investigated the effect of Treg skewing on the phenotypic and functional properties of CD4(+) CD127(+) CD25(high) cells, an activated subset of Teff, in 32 patients with AIH, 20 with AISC and in 36 healthy subjects (HS)...
June 9, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28531919/bupleurum-chinense-extract-ameliorates-an-ova-induced-murine-allergic-asthma-through-the-reduction-of-the-th2-and-th17-cytokines-production-by-inactivation-of-nf%C3%AE%C2%BAb-pathway
#14
Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Hee Soon Shin, Ok Hee Chai
Bupleurum chinense belongs to the Bupleurum spp. family that has been used in traditional herbal medicine for over thousand years. It has been reported to have anti-inflammatory, anti-oxidant, hepato-protective, antipyretic, analgesic, anti-fibrotic and immunomodulatory effect. However, the effect of B. Chinense on allergic asthma remains unclear. This study investigated the immunomodulatory effects of B. Chinense extracts (BCE) on airway inflammation in asthmatic mice model. In the ovalbumin (OVA)-induced allergic asthma model, we evaluated the number of total cells, differential inflammatory cells and the production of proinflammatory cytokines in bronchoalveolar lavage fluid (BALF) and lung homogenate as well as histological structure...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28527809/accuracy-of-genomic-predictions-in-gyr-bos-indicus-dairy-cattle
#15
S A Boison, A T H Utsunomiya, D J A Santos, H H R Neves, R Carvalheiro, G Mészáros, Y T Utsunomiya, A S do Carmo, R S Verneque, M A Machado, J C C Panetto, J F Garcia, J Sölkner, M V G B da Silva
Genomic selection may accelerate genetic progress in breeding programs of indicine breeds when compared with traditional selection methods. We present results of genomic predictions in Gyr (Bos indicus) dairy cattle of Brazil for milk yield (MY), fat yield (FY), protein yield (PY), and age at first calving using information from bulls and cows. Four different single nucleotide polymorphism (SNP) chips were studied. Additionally, the effect of the use of imputed data on genomic prediction accuracy was studied...
July 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28493520/hbv-specific-cd4-cytotoxic-t-cells-in-hepatocellular-carcinoma-are-less-cytolytic-toward-tumor-cells-and-suppress-cd8-t-cell-mediated-antitumor-immunity
#16
Fanzhi Meng, Shoumei Zhen, Bin Song
In East Asia and sub-Saharan Africa, chronic infection is the main cause of the development of hepatocellular carcinoma, an aggressive cancer with low survival rate. Cytotoxic T cell-based immunotherapy is a promising treatment strategy. Here, we investigated the possibility of using HBV-specific CD4(+) cytotoxic T cells to eliminate tumor cells. The naturally occurring HBV-specific cytotoxic CD4(+) and CD8(+) T cells were identified by HBV peptide pool stimulation. We found that in HBV-induced hepatocellular carcinoma patients, the HBV-specific cytotoxic CD4(+) T cells and cytotoxic CD8(+) T cells were present at similar numbers...
May 11, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28484460/intralymphatic-administration-of-adipose-mesenchymal-stem-cells-reduces-the-severity-of-collagen-induced-experimental-arthritis
#17
Pablo Mancheño-Corvo, Mercedes Lopez-Santalla, Ramon Menta, Olga DelaRosa, Francisca Mulero, Borja Del Rio, Cristina Ramirez, Dirk Büscher, Juan A Bueren, Juan Lopez-Belmonte, Wilfried Dalemans, Marina I Garin, Eleuterio Lombardo
Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues associated with the inflammatory site where functional MSC-induced immune cells with a regulatory phenotype were increased mediating the immunomodulatory effects of MSCs. These results suggest that homing of MSCs to the lymphatic system plays an important role in the mechanism of action of MSCs in vivo...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28472606/a-simple-and-efficient-non-denaturing-fish-method-for-maize-chromosome-differentiation-using-single-strand-oligonucleotide-probes
#18
Minqiu Zhu, Pei du, Lifang Zhuang, Chenggen Chu, Han Zhao, Zengjun Qi
Single-strand oligonucleotides (SSONs hereafter) as probes are becoming a powerful method of chromosome painting in many species. In this study, nine SSONs ((ACT)10, (ACT)19, Knob-1 ~ 3, CentC69-1, MR68-3, K10-72-1 and TR1-357-2) were developed and used for chromosome identification in 16 maize (Zea mays L., 2n = 20) inbred lines and hybrids by non-denaturing fluorescence in situ hybridization (ND-FISH). Each SSON produced clear signals on 2 ~ 10 chromosomes of inbred lines B73 and Mo17. A multiplex probe set containing four SSONs ((ACT)10, Knob-2, CentC69-1 and MR68-3) clearly characterized all maize chromosomes in the 16 lines by a single round of ND-FISH and revealed genetic variation at a chromosome level...
May 4, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28470464/expanding-diversity-and-common-goal-of-regulatory-t-and-b-cells-ii-in-allergy-malignancy-and-transplantation
#19
REVIEW
Grażyna Korczak-Kowalska, Anna Stelmaszczyk-Emmel, Katarzyna Bocian, Ewelina Kiernozek, Nadzieja Drela, Joanna Domagała-Kulawik
Regulation of immune response was found to play an important role in the course of many diseases such as autoimmune diseases, allergy, malignancy, organ transplantation. The studies on immune regulation focus on the role of regulatory cells (Tregs, Bregs, regulatory myeloid cells) in these disorders. The number and function of Tregs may serve as a marker of disease activity. As in allergy, the depletion of Tregs is observed and the results of allergen-specific immunotherapy could be measured by an increase in the population of IL-10(+) regulatory cells...
May 3, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28439004/endocannabinoid-system-acts-as-a-regulator-of-immune-homeostasis-in-the-gut
#20
Nandini Acharya, Sasi Penukonda, Tatiana Shcheglova, Adam T Hagymasi, Sreyashi Basu, Pramod K Srivastava
Endogenous cannabinoids (endocannabinoids) are small molecules biosynthesized from membrane glycerophospholipid. Anandamide (AEA) is an endogenous intestinal cannabinoid that controls appetite and energy balance by engagement of the enteric nervous system through cannabinoid receptors. Here, we uncover a role for AEA and its receptor, cannabinoid receptor 2 (CB2), in the regulation of immune tolerance in the gut and the pancreas. This work demonstrates a major immunological role for an endocannabinoid. The pungent molecule capsaicin (CP) has a similar effect as AEA; however, CP acts by engagement of the vanilloid receptor TRPV1, causing local production of AEA, which acts through CB2...
May 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
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