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Blanc reactions

Minhui Han, Xiaodong Ma, Shangchu Yao, Yuxuan Ding, Zihan Yan, Adila Adijiang, Yufei Wu, Hengzhao Li, Yuntong Zhang, Peng Lei, Yun Ling, Jie An
A modified Bouveault-Blanc reduction has been developed for the synthesis of α,α-dideuterio alcohols from carboxylic acid esters. Sodium dispersions are used as the electron donor in this electron transfer reaction, and ethanol-d1 is employed as the deuterium source. This reaction uses stable, cheap, and commercially available reagents, is operationally simple, and results in excellent deuterium incorporation across a broad range of aliphatic esters, which provides an attractive alternative to reactions mediated by expensive pyrophoric alkali metal deuterides...
January 9, 2017: Journal of Organic Chemistry
Blandine Rougemont, Sébastien Bontemps Gallo, Sophie Ayciriex, Romain Carriere, Hubert Hondermarck, Jean-Marie Lacroix, J C Yves Le Blanc, Jerome Lemoine
Targeted-mass spectrometry of surrogate peptide panel is a powerful method to study the dynamics of protein networks, but chromatographic time scheduling remains a major limitation for dissemination and implementation of robust and large multiplexed assays. We unveil a Multiple Reaction Monitoring method (Scout-MRM) where the use of spiked scout peptides triggers complex transition lists regardless of the retention time of targeted surrogate peptides. The interest of Scout-MRM method regarding the retention time independency, multiplexing capability, reproducibility and putative interest in facilitating method transfer was illustrated by a 782-peptide-plex relative assay targeting 445 proteins of the phytopathogen Dickeya dadantii during plant infection...
December 27, 2016: Analytical Chemistry
Alina L Evans, Navinder J Singh, Boris Fuchs, Stéphane Blanc, Andrea Friebe, Timothy G Laske, Ole Frobert, Jon E Swenson, Jon M Arnemo
Human disturbance can affect animal life history and even population dynamics. However, the consequences of these disturbances are difficult to measure. This is especially true for hibernating animals, which are highly vulnerable to disturbance, because hibernation is a process of major physiological changes, involving conservation of energy during a resource-depleted time of year. During the winters of 2011-15, we captured 15 subadult brown bears (Ursus arctos) and recorded their body temperatures (n = 11) and heart rates (n = 10) before, during and after capture using biologgers...
2016: Conservation Physiology
Lindsay C Davies, Jessica J Alm, Nina Heldring, Guido Moll, Caroline Gavin, Ioannis Batsis, Hong Qian, Mikael Sigvardsson, Bo Nilsson, Lauri E Kyllonen, Kaija T Salmela, Per-Ola Carlsson, Olle Korsgren, Katarina Le Blanc
: : Bone marrow mesenchymal stromal cells (BM-MSCs) have been characterized and used in many clinical studies based on their immunomodulatory and regenerative properties. We have recently reported the benefit of autologous MSC systemic therapy in the treatment of type 1 diabetes mellitus (T1D). Compared with allogeneic cells, use of autologous products reduces the risk of eliciting undesired complications in the recipient, including rejection, immunization, and transmission of viruses and prions; however, comparable potency of autologous cells is required for this treatment approach to remain feasible...
July 13, 2016: Stem Cells Translational Medicine
Xiaolu Wang, Martin In, Christophe Blanc, Paolo Malgaretti, Maurizio Nobili, Antonio Stocco
Janus colloidal particles show remarkable properties in terms of surface activity, self-assembly and wetting. Moreover they can perform autonomous motion if they can chemically react with the liquid in which they are immersed. In order to understand the self-propelled motion of catalytic Janus colloids at the air-water interface, wetting and the orientation of the catalytic surface are important properties to be investigated. Wetting plays a central role in active motion since it determines the contact between the fuel and the catalytic surface as well as the efficiency of the transduction of the chemical reaction into motion...
July 14, 2016: Faraday Discussions
Solène Miaskiewicz, Boris Gaillard, Nicolas Kern, Jean-Marc Weibel, Patrick Pale, Aurélien Blanc
Valuable 1-azabicycloalkane derivatives have been synthesized through a novel gold(I)-catalyzed desulfonylative cyclization strategy. An ammoniumation reaction of ynones substituted at the 1-position with an N-sulfonyl azacycle took place in the presence of a gold cation by intramolecular cyclization of the disubstituted sulfonamide moiety onto the triple bond. Depending on the size of the heterocyclic ring and substitution of the substrates, two unprecedented forms of nucleophilic attack on the sulfonyl group were exploited, that is, a N-desulfonylation in the presence of an external protic O nucleophile (37-87 %, 10 examples) and a unique N-to-O 1,5-sulfonyl migration (60-98 %, 9 examples)...
July 25, 2016: Angewandte Chemie
Lydia N Djouadi, Anthony Levasseur, Jacques Bou Khalil, Caroline Blanc-Taileur, Shady Asmar, Wassila Ghiloubi, Farida Natèche, Michel Drancourt
An acid-fast, rapidly growing, rod-shaped microorganism designated 8WA6 was isolated from a lake in Algiers, Algeria. The lake water was characterized by a temperature of 18 °C, a pH of 7.82, a copper concentration of 8.6 µg/L, and a cadmium concentration of 0.6 µg/L. First-line molecular identification confirmed the 8WA6 isolate to be a member of the Mycobacterium terrae complex, sharing 99.4 % 16S rRNA gene sequence similarity with M. arupense AR-30097, 98.2 % partial hsp65 gene sequence similarity with M...
August 2016: Current Microbiology
Alexandra J Salter-Blanc, Eric J Bylaska, Molly A Lyon, Stuart C Ness, Paul G Tratnyek
New energetic compounds are designed to minimize their potential environmental impacts, which includes their transformation and the fate and effects of their transformation products. The nitro groups of energetic compounds are readily reduced to amines, and the resulting aromatic amines are subject to oxidation and coupling reactions. Manganese dioxide (MnO2) is a common environmental oxidant and model system for kinetic studies of aromatic amine oxidation. In this study, a training set of new and previously reported kinetic data for the oxidation of model and energetic-derived aromatic amines was assembled and subjected to correlation analysis against descriptor variables that ranged from general purpose [Hammett σ constants (σ(-)), pKas of the amines, and energies of the highest occupied molecular orbital (EHOMO)] to specific for the likely rate-limiting step [one-electron oxidation potentials (Eox)]...
May 17, 2016: Environmental Science & Technology
Anne-Cécile Petit, Julien Eutrope, Aurore Thierry, Nathalie Bednarek, Laurence Aupetit, Stéphanie Saad, Lauriane Vulliez, Daniel Sibertin-Blanc, Sylvie Nezelof, Anne-Catherine Rolland
OBJECTIVES: Very preterm infants are known to be at risk of developmental disabilities and behavioural disorders. This condition is supposed to alter mother-infant interactions. Here we hypothesize that the parental coping with the very preterm birth may greatly influence mother-infant interactions. METHODS: 100 dyads were included in 3 university hospitals in France. Preterm babies at higher risk of neurodevelopmental sequelae (PRI>10) were excluded to target the maternal determinants of mother-infant interaction...
2016: PloS One
Solène Miaskiewicz, Jean-Marc Weibel, Patrick Pale, Aurélien Blanc
Polysubstituted pyrrolin-4-ones have been efficiently synthesized from readily available 1-(N-sulfonylazetidin-2-yl) ynones via gold(I)-catalyzed cyclization/nucleophilic substitution in the presence of various nucleophiles, such as water, alcohols, or indoles. Additionally, 3-iodopyrrolin-4-one derivatives have also been obtained under the same reaction conditions upon addition of 1.2 equiv of N-iodosuccinimide.
February 19, 2016: Organic Letters
Lisa Giovannini-Chami, Sibylle Blanc, Alice Hadchouel, André Baruchel, Rachida Boukari, Jean-Christophe Dubus, Michael Fayon, Muriel Le Bourgeois, Nadia Nathan, Marc Albertini, Annick Clément, Jacques de Blic
Pediatric eosinophilic pneumonias (EPs) are characterized by a significant infiltration of the alveolar spaces and lung interstitium by eosinophils, with conservation of the lung structure. In developed countries, EPs constitute exceptional entities in pediatric care. Clinical symptoms may be transient (Löffler syndrome), acute (<1 month and mostly <7 days), or chronic (>1 month). Diagnosis relies on demonstration of alveolar eosinophilia on bronchoalveolar lavage, whether or not associated with blood eosinophilia...
February 2016: Pediatric Pulmonology
Christelle Blanc, Marianne Zeller, Yves Cottin, Benoit Daubail, Anne-Laure Vialatte, Maurice Giroud, Yannick Béjot
OBJECTIVE: Takotsubo cardiomyopathy (TCM) is characterized by transient apical ventricular dysfunction typically induced by acute stress. Acute cerebral events including ischemic stroke (IS) or epileptic events (EEs) may be associated with massive catecholamine release. We aimed to identify the characteristics and outcomes of patients who experienced the Takotsubo syndrome complicated by IS or EE. METHODS: Between 2008 and 2013, 87 patients were admitted to our intensive care unit for TCM...
2015: European Neurology
M Stojanov, B Magalhaes, V Terletsky, P Basset, G Prod'hom, G Greub, L Senn, D S Blanc
Despite the development of novel typing methods based on whole genome sequencing, most laboratories still rely on classical molecular methods for outbreak investigation or surveillance. Reference methods for Clostridium difficile include ribotyping and pulsed-field gel electrophoresis, which are band-comparing methods often difficult to establish and which require reference strain collections. Here, we present the double locus sequence typing (DLST) scheme as a tool to analyse C. difficile isolates. Using a collection of clinical C...
February 2016: European Journal of Clinical Microbiology & Infectious Diseases
Xiaolu Wang, Martin In, Christophe Blanc, Maurizio Nobili, Antonio Stocco
We have investigated the active motion of self-propelled colloids confined at the air-water interface and explored the possibility of enhancing the directional motion of self-propelled Janus colloids by slowing down their rotational diffusion. The two dimensional motion of micron-sized silica-platinum Janus colloids has been experimentally measured by particle tracking video-microscopy at increasing concentrations of the catalytic fuel, i.e. H2O2. Compared to the motion in the bulk, a dramatic enhancement of both the persistence length of trajectories and the speed has been observed...
October 7, 2015: Soft Matter
Jean-Luc Malo, Susan M Tarlo, Joaquin Sastre, James Martin, Mohamed F Jeebhay, Nicole Le Moual, Dick Heederik, Thomas Platts-Mills, Paul D Blanc, Olivier Vandenplas, Gianna Moscato, Frédéric de Blay, André Cartier
The fifth Jack Pepys Workshop on Asthma in the Workplace focused on the similarities and differences of work-related asthma (WRA) and non-work-related asthma (non-WRA). WRA includes occupational asthma (OA) and work-exacerbated asthma (WEA). There are few biological differences in the mechanisms of sensitization to environmental and occupational allergens. Non-WRA and OA, when due to high-molecular-weight agents, are both IgE mediated; it is uncertain whether OA due to low-molecular-weight agents is also IgE mediated...
July 2015: Annals of the American Thoracic Society
Kenneth J Olejar, Bruno Fedrizzi, Paul A Kilmartin
Sauvignon blanc wines are characterised by their varietal aromas and low phenolic content. Mechanical harvesting has been shown to increase several varietal aromas. Likewise, maceration techniques have produced increases in phenolic content and antioxidant activity, but these can also alter tactile attributes and sensory profiles. Mechanical harvesting and cryogenic maceration were used in combination to produce a Sauvignon blanc wine with increased phenolic content and antioxidant activity, while showing a similar sensory profile to control wines...
September 15, 2015: Food Chemistry
Esteban D Babot, José C Del Río, Marina Cañellas, Ferran Sancho, Fátima Lucas, Víctor Guallar, Lisbeth Kalum, Henrik Lund, Glenn Gröbe, Katrin Scheibner, René Ullrich, Martin Hofrichter, Angel T Martínez, Ana Gutiérrez
The goal of this study is the selective oxyfunctionalization of steroids under mild and environmentally friendly conditions using fungal enzymes. With this purpose, peroxygenases from three basidiomycete species were tested for the hydroxylation of a variety of steroidal compounds, using H2O2 as the only cosubstrate. Two of them are wild-type enzymes from Agrocybe aegerita and Marasmius rotula, and the third one is a recombinant enzyme from Coprinopsis cinerea. The enzymatic reactions on free and esterified sterols, steroid hydrocarbons, and ketones were monitored by gas chromatography, and the products were identified by mass spectrometry...
June 15, 2015: Applied and Environmental Microbiology
Alexandra J Salter-Blanc, Eric J Bylaska, Hayley J Johnston, Paul G Tratnyek
The evaluation of new energetic nitroaromatic compounds (NACs) for use in green munitions formulations requires models that can predict their environmental fate. Previously invoked linear free energy relationships (LFER) relating the log of the rate constant for this reaction (log(k)) and one-electron reduction potentials for the NAC (E1NAC) normalized to 0.059 V have been re-evaluated and compared to a new analysis using a (nonlinear) free-energy relationship (FER) based on the Marcus theory of outer-sphere electron transfer...
March 17, 2015: Environmental Science & Technology
Jean-Jacques Blanc, Paolo Alboni, David G Benditt
Vasovagal syncope (VVS) is not known to occur in animals, although other similar reflex responses are common. This review examines the possible relation of these latter presumably protective reflexes in animals to VVS in humans. The goal is to provide practitioners, and ultimately their patients, a meaningful understanding of the origins and appropriate management of this unpredictable affliction. This report utilized review of computer databases (e.g. PubMed) addressing VVS pathophysiology and origins, spontaneous transient loss of consciousness in animals, and comparative physiology...
March 2015: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Camille Sibertin-Blanc, Julien Mancini, Aurélie Fabre, Arnaud Lagarde, Jean Del Grande, Nicolas Levy, Jean-François Seitz, Sylviane Olschwang, Laetitia Dahan
BACKGROUND: No predictive marker has been yet identified for bevacizumab which is widely used in metastatic colorectal cancer. AIMS: Evaluate impact of single nucleotide polymorphisms involved in Vascular Endothelial Growth Factor pathway on efficacy and tolerance of bevacizumab. METHODS: We retrospectively included patients who were treated with bevacizumab-based chemotherapy for metastatic colorectal cancer, and for whom a deoxyribonucleic acid sample was available...
April 2015: Digestive and Liver Disease
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