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Methylphenydate

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https://www.readbyqxmd.com/read/22500377/depressive-symptoms-as-a-side-effect-of-the-sustained-release-form-of-methylphenidate-in-a-7-year-old-boy-with-attention-deficit-hyperactivity-disorder
#1
Aneta Lakić
INTRODUCTION: Hyperkinetic disorder or attention-deficit hyperactivity disorder (ADHD) is a clinical entity consisting of a cluster of symptoms including hyperactivity, attention disorder and impulse control disorder group. In the context of ADHD etiology we may say that genetic, clinical and imaging studies point out a disruption of the brain dopamine system, which is corroborated by the clinical effectiveness of stimulant drugs, which increase extracellular dopamine in the brain. Basically, it is a biological and not psychological disorder, which is important both for the comprehension and therapeutical approach to this problem...
February 2012: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/10654662/non-selective-attention-in-a-rat-model-of-hyperactivity-and-attention-deficit-subchronic-methylphenydate-and-nitric-oxide-synthesis-inhibitor-treatment
#2
R Aspide, A Fresiello, G de Filippis, U A Gironi Carnevale, A G Sadile
The involvement of dopamine (DA) and nitric oxide (NO) in the process of non-selective attention (NSA) to environmental stimuli has been investigated in the juvenile Spontaneously Hypertensive rat (SHR). To this aim the frequency and duration of rearing episodes in a novelty situation, which is thought to monitor NSA, have been measured in male SHR and Wistar-Kyoto (WKY) control rats following subchronic treatment with methylphenidate (MP; 3 mg/kg) or the nitric oxide synthase (NOS) inhibitor L-Nitro-arginine-methylester (L-NAME; 1 mg/kg) or vehicle daily for two weeks...
January 2000: Neuroscience and Biobehavioral Reviews
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