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https://www.readbyqxmd.com/read/28239628/cubic-meter-volume-optical-coherence-tomography
#1
Zhao Wang, Benjamin Potsaid, Long Chen, Chris Doerr, Hsiang-Chieh Lee, Torben Nielson, Vijaysekhar Jayaraman, Alex E Cable, Eric Swanson, James G Fujimoto
Optical coherence tomography (OCT) is a powerful three-dimensional (3D) imaging modality with micrometer-scale axial resolution and up to multi-GigaVoxel/s imaging speed. However, the imaging range of high-speed OCT has been limited. Here, we report 3D OCT over cubic meter volumes using a long coherence length, 1310 nm vertical-cavity surface-emitting laser and silicon photonic integrated circuit dual-quadrature receiver technology combined with enhanced signal processing. We achieved 15 µm depth resolution for tomographic imaging at a 100 kHz axial scan rate over a 1...
December 2016: Optica
https://www.readbyqxmd.com/read/28229306/behavioral-and-social-sciences-at-the-national-institutes-of-health-adoption-of-research-findings-in-health-research-and-practice-as-a-scientific-priority
#2
William T Riley
The National Institutes of Health's Office of Behavioral and Social Sciences Research (OBSSR) recently released its Strategic Plan for 2017 to 2021. This plan highlights three scientific priorities: (1) improve the synergy of basic and applied behavioral and social sciences research, (2) enhance and promote the research infrastructure, methods, and measures needed to support a more cumulative and integrated approach to behavioral and social sciences research, and (3) facilitate the adoption of behavioral and social sciences research findings in health research and in practice...
February 22, 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28227676/initial-experiments-of-a-128-channel-fpga-and-pc-based-ultrasound-imaging-system-for-teaching-and-research-activities
#3
Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa, Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa, Amauri Amorin Assef, Joaquim Miguel Maia, Eduardo Tavares Costa
Although widely employed in medical diagnostic applications, most of the available commercial ultrasound (US) scanners do not always fit the needs of research users. Access to raw US data, portability, flexibility and advanced user control are essential features to explore alternative biomedical signal and imaging processing algorithms. In this paper, we present the initial results of a reconfigurable, cost-effective and modular 128-channel FPGA and PC-based US system, specifically designed for teaching and medical imaging research...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227471/defining-new-aims-for-bme-programs-in-latin-america-the-case-of-uam-iztapalapa
#4
J Azpiroz-Leehan, L F Martinez, M E G Urbina, M M Cadena, E Sacristan, J Azpiroz-Leehan, L F Martinez, M E G Urbina, M M Cadena, E Sacristan, M M Cadena, M E G Urbina, E Sacristan, J Azpiroz-Leehan, L F Martinez
The need for upkeep and management of medical technology has fostered the creation of a large number of under graduate programs in the field of biomedical Engineering. In Latin America alone, there are over 85 programs dedicated to this. This contrasts with programs in other regions where most of the undergraduates continue on to pursue graduate degrees or work as research and development engineers in the biomedical industry. In this work we analyze the situation regarding curricular design in the 48 BME programs in Mexico and compare this to suggestions and classifications of programs according to needs and possibilities...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226897/effect-of-growth-solution-membrane-size-and-array-connection-on-microbial-fuel-cell-power-supply-for-medical-devices
#5
Daniel N Roxby, Nham Tran, Pak-Lam Yu, Hung T Nguyen, Daniel N Roxby, Nham Tran, Pak-Lam Yu, Hung T Nguyen, Pak-Lam Yu, Hung T Nguyen, Daniel N Roxby, Nham Tran
Implanted biomedical devices typically last a number of years before their batteries are depleted and a surgery is required to replace them. A Microbial Fuel Cell (MFC) is a device which by using bacteria, directly breaks down sugars to generate electricity. Conceptually there is potential to continually power implanted medical devices for the lifetime of a patient. To investigate the practical potential of this technology, H-Cell Dual Chamber MFCs were evaluated with two different growth solutions and measurements recorded for maximum power output both of individual MFCs and connected MFCs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226521/eda-gram-designing-electrodermal-activity-fingerprints-for-visualization-and-feature-extraction
#6
Theodora Chaspari, Andreas Tsiartas, Leah I Stein Duker, Sharon A Cermak, Shrikanth S Narayanan, Theodora Chaspari, Andreas Tsiartas, Leah I Stein Duker, Sharon A Cermak, Shrikanth S Narayanan, Andreas Tsiartas, Theodora Chaspari, Sharon A Cermak, Shrikanth S Narayanan, Leah I Stein Duker
Wearable technology permeates every aspect of our daily life increasing the need of reliable and interpretable models for processing the large amount of biomedical data. We propose the EDA-Gram, a multidimensional fingerprint of the electrodermal activity (EDA) signal, inspired by the widely-used notion of spectrogram. The EDA-Gram is based on the sparse decomposition of EDA from a knowledge-driven set of dictionary atoms. The time axis reflects the analysis frames, the spectral dimension depicts the width of selected dictionary atoms, while intensity values are computed from the atom coefficients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226218/assessing-cartilage-biomechanical-properties-techniques-for-evaluating-the-functional-performance-of-cartilage-in-health-and-disease
#7
Benjamin A Lakin, Brian D Snyder, Mark W Grinstaff
Osteoarthritis (OA) affects millions of people and results in weakened hyaline cartilage due to overloading. During joint articulation, hyaline cartilage must withstand high loads while maintaining low friction to prevent wear and tissue loss. Thus, cartilage compressive stiffness and the coefficient of friction are important indicators of the tissue's functional performance. These mechanical properties are often measured ex vivo using mechanical testing regimens, but arthroscopic handheld probes (e.g., for indentation testing, ultrasound, and optical coherence tomography) and noninvasive imaging modalities (e...
February 2, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28220752/putting-3d-modelling-and-3d-printing-into-practice-virtual-surgery-and-preoperative-planning-to-reconstruct-complex-post-traumatic-skeletal-deformities-and-defects
#8
Kevin Tetsworth, Steve Block, Vaida Glatt
3D printing technology has revolutionized and gradually transformed manufacturing across a broad spectrum of industries, including healthcare. Nowhere is this more apparent than in orthopaedics with many surgeons already incorporating aspects of 3D modelling and virtual procedures into their routine clinical practice. As a more extreme application, patient-specific 3D printed titanium truss cages represent a novel approach for managing the challenge of segmental bone defects. This review illustrates the potential indications of this innovative technique using 3D printed titanium truss cages in conjunction with the Masquelet technique...
2017: SICOT-J
https://www.readbyqxmd.com/read/28220145/where-sepsis-and-antimicrobial-resistance-countermeasures-converge
#9
Timothy J J Inglis, Nadia Urosevic
The United Nations General Assembly debate on antimicrobial resistance (AMR) recognizes the global significance of AMR. Much work needs to be done on technology capability and capacity to convert the strategic intent of the debate into operational plans and tangible outcomes. Enhancement of the biomedical science-clinician interface requires better exploitation of systems biology tools for in-laboratory and point of care methods that detect sepsis and characterize AMR. These need to link sepsis and AMR data with responsive, real-time surveillance...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28219348/distribution-based-nearest-neighbor-imputation-for-truncated-high-dimensional-data-with-applications-to-pre-clinical-and-clinical-metabolomics-studies
#10
Jasmit S Shah, Shesh N Rai, Andrew P DeFilippis, Bradford G Hill, Aruni Bhatnagar, Guy N Brock
BACKGROUND: High throughput metabolomics makes it possible to measure the relative abundances of numerous metabolites in biological samples, which is useful to many areas of biomedical research. However, missing values (MVs) in metabolomics datasets are common and can arise due to both technical and biological reasons. Typically, such MVs are substituted by a minimum value, which may lead to different results in downstream analyses. RESULTS: Here we present a modified version of the K-nearest neighbor (KNN) approach which accounts for truncation at the minimum value, i...
February 20, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28218353/biomimetic-principles-to-develop-blood-compatible-surfaces
#11
Vladislav Semak, Michael B Fischer, Viktoria Weber
Functionalized biomaterial surface patterns capable of resisting nonspecific adsorption while retaining their bioactivity are crucial in the advancement of biomedical technologies, but currently available biomaterials intended for use in whole blood frequently suffer from nonspecific adsorption of proteins and cells, leading to a loss of activity over time. In this review, we address two concepts for the design and modification of blood compatible biomaterial surfaces, zwitterionic modification and surface functionalization with glycans - both of which are inspired by the membrane structure of mammalian cells - and discuss their potential for biomedical applications...
February 13, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28216054/lipidomics-en-route-to-accurate-quantitation
#12
REVIEW
Sin Man Lam, He Tian, Guanghou Shui
Accurate quantitation is prerequisite for the sustainable development of lipidomics via enabling its applications in various biological and biomedical settings. In this review, the technical considerations and limitations of existent lipidomics technologies, particularly in terms of accurate quantitation; as well as the potential sources of errors along a typical lipidomic workflow that could ultimately give rise to quantitative inaccuracies will be addressed. Furthermore, the pressing need to exercise stricter definitions of terms and protocol standardization pertaining to quantitative lipidomics will be critically discussed, as quantitative accuracy may substantially impact upon the persevering development of lipidomics in the long run...
February 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28215329/biotechnological-applications-of-marine-enzymes-from-algae-bacteria-fungi-and-sponges
#13
S Parte, V L Sirisha, J S D'Souza
Diversity is the hallmark of all life forms that inhabit the soil, air, water, and land. All these habitats pose their unique inherent challenges so as to breed the "fittest" creatures. Similarly, the biodiversity from the marine ecosystem has evolved unique properties due to challenging environment. These challenges include permafrost regions to hydrothermal vents, oceanic trenches to abyssal plains, fluctuating saline conditions, pH, temperature, light, atmospheric pressure, and the availability of nutrients...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28215321/biomedical-applications-of-enzymes-from-marine-actinobacteria
#14
K Kamala, P Sivaperumal
Marine microbial enzyme technologies have progressed significantly in the last few decades for different applications. Among the various microorganisms, marine actinobacterial enzymes have significant active properties, which could allow them to be biocatalysts with tremendous bioactive metabolites. Moreover, marine actinobacteria have been considered as biofactories, since their enzymes fulfill biomedical and industrial needs. In this chapter, the marine actinobacteria and their enzymes' uses in biological activities and biomedical applications are described...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28214993/scaleus-semantic-web-services-integration-for-biomedical-applications
#15
Pedro Sernadela, Lorena González-Castro, José Luís Oliveira
In recent years, we have witnessed an explosion of biological data resulting largely from the demands of life science research. The vast majority of these data are freely available via diverse bioinformatics platforms, including relational databases and conventional keyword search applications. This type of approach has achieved great results in the last few years, but proved to be unfeasible when information needs to be combined or shared among different and scattered sources. During recent years, many of these data distribution challenges have been solved with the adoption of semantic web...
April 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28213959/combining-induced-pluripotent-stem-cells-and-genome-editing-technologies-for-clinical-applications
#16
Chia-Yu Chang, Hsiao-Chien Ting, Hong-Lin Su, Jing-Ren Jeng
In this review, we introduce current developments in induced pluripotent stem cells (iPSCs), site-specific nuclease (SSN)-mediated genome editing tools, and the combined application of these two novel technologies in biomedical research and therapeutic trials. The sustainable pluripotent property of iPSCs in vitro not only provides unlimited cell sources for basic research but also benefits precision medicines for human diseases. In addition, rapidly evolving SSN tools efficiently tailor genetic manipulations for exploring gene functions and can be utilized to correct genetic defects of congenital diseases in the near future...
February 17, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28213833/molecular-imaging-in-synthetic-biology-and-synthetic-biology-in-molecular-imaging
#17
REVIEW
Assaf A Gilad, Mikhail G Shapiro
Biomedical synthetic biology is an emerging field in which cells are engineered at the genetic level to carry out novel functions with relevance to biomedical and industrial applications. This approach promises new treatments, imaging tools, and diagnostics for diseases ranging from gastrointestinal inflammatory syndromes to cancer, diabetes, and neurodegeneration. As these cellular technologies undergo pre-clinical and clinical development, it is becoming essential to monitor their location and function in vivo, necessitating appropriate molecular imaging strategies, and therefore, we have created an interest group within the World Molecular Imaging Society focusing on synthetic biology and reporter gene technologies...
February 17, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28208801/atomic-force-microscopy-a-powerful-tool-to-address-scaffold-design-in-tissue-engineering
#18
Marica Marrese, Vincenzo Guarino, Luigi Ambrosio
Functional polymers currently represent a basic component of a large range of biological and biomedical applications including molecular release, tissue engineering, bio-sensing and medical imaging. Advancements in these fields are driven by the use of a wide set of biodegradable polymers with controlled physical and bio-interactive properties. In this context, microscopy techniques such as Atomic Force Microscopy (AFM) are emerging as fundamental tools to deeply investigate morphology and structural properties at micro and sub-micrometric scale, in order to evaluate the in time relationship between physicochemical properties of biomaterials and biological response...
February 13, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28203277/semantics-based-plausible-reasoning-to-extend-the-knowledge-coverage-of-medical-knowledge-bases-for-improved-clinical-decision-support
#19
Hossein Mohammadhassanzadeh, William Van Woensel, Samina Raza Abidi, Syed Sibte Raza Abidi
BACKGROUND: Capturing complete medical knowledge is challenging-often due to incomplete patient Electronic Health Records (EHR), but also because of valuable, tacit medical knowledge hidden away in physicians' experiences. To extend the coverage of incomplete medical knowledge-based systems beyond their deductive closure, and thus enhance their decision-support capabilities, we argue that innovative, multi-strategy reasoning approaches should be applied. In particular, plausible reasoning mechanisms apply patterns from human thought processes, such as generalization, similarity and interpolation, based on attributional, hierarchical, and relational knowledge...
2017: BioData Mining
https://www.readbyqxmd.com/read/28202491/organoid-technologies-meet-genome-engineering
#20
REVIEW
Jing Nie, Eri Hashino
Three-dimensional (3D) stem cell differentiation cultures recently emerged as a novel model system for investigating human embryonic development and disease progression in vitro, complementing existing animal and two-dimensional (2D) cell culture models. Organoids, the 3D self-organizing structures derived from pluripotent or somatic stem cells, can recapitulate many aspects of structural organization and functionality of their in vivo organ counterparts, thus holding great promise for biomedical research and translational applications...
February 15, 2017: EMBO Reports
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