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https://www.readbyqxmd.com/read/28815231/fluorescence-activated-cell-sorting-via-a-focused-traveling-surface-acoustic-beam
#1
Zhichao Ma, Yinning Zhou, David J Collins, Ye Ai
Fluorescence activated cell sorting (FACS) has become an essential technique widely exploited in biological studies and clinical applications. However, current FACS systems are quite complex, expensive, bulky, and pose potential sample contamination and biosafety issues due to the generation of aerosols in an open environment. Microfluidic technology capable of precise cell manipulation has great potential to reinvent and miniaturize conventional FACS systems. In this work, we demonstrate a benchtop scale FACS system that makes use of a highly focused traveling surface acoustic wave beam to sort out micron-sized particles and biological cells upon fluorescence interrogation at ∼kHz rates...
August 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28815122/incorporating-data-citation-in-a-biomedical-repository-an-implementation-use-case
#2
Snehil Gupta, Connie Zabarovskaya, Brian Romine, Daniel A Vianello, Cynthia Hudson Vitale, Leslie D McIntosh
Research data is a dynamic and evolving entity and the ability to cite such data depends on recreating the same datasets utilized in the original research. Despite the availability of several existing technologies, most data repositories lack the necessary setup to recreate a point-in-time snapshot of data, let alone long-term sustainability of dynamic data without restoring an entire database. Through this project, we adopted a subset of the Research Data Alliance data citation working group recommendations to establish a robust informatics system supporting dynamic data and its use for reproducible research within our evolving clinical data repository...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28815110/development-of-a-framework-for-large-scale-three-dimensional-pathology-and-biomarker-imaging-and-spatial-analytics
#3
Yanhui Liang, Fusheng Wang, Pengyue Zhang, Joel H Saltz, Daniel J Brat, Jun Kong
With the rapid advancement in large-throughput scanning technologies, digital pathology has emerged as platform with promise for diagnostic approaches, but also for high-throughput quantitative data extraction and analysis for translational research. Digital pathology and biomarker images are rich sources of information on tissue architecture, cell diversity and morphology, and molecular pathway activation. However, the understanding of disease in three-dimension (3D) has been hampered by their traditional two-dimension (2D) representations on histologic slides...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28812001/recent-advances-in-terahertz-technology-for-biomedical-applications
#4
REVIEW
Qiushuo Sun, Yuezhi He, Kai Liu, Shuting Fan, Edward P J Parrott, Emma Pickwell-MacPherson
Terahertz instrumentation has improved significantly in recent years such that THz imaging systems have become more affordable and easier to use. THz systems can now be operated by non-THz experts greatly facilitating research into many potential applications. Due to the non-ionising nature of THz light and its high sensitivity to soft tissues, there is an increasing interest in biomedical applications including both in vivo and ex vivo studies. Additionally, research continues into understanding the origin of contrast and how to interpret terahertz biomedical images...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28811584/nanopriming-technology-for-enhancing-germination-and-starch-metabolism-of-aged-rice-seeds-using-phytosynthesized-silver-nanoparticles
#5
Wuttipong Mahakham, Ajit K Sarmah, Santi Maensiri, Piyada Theerakulpisut
Application of nanomaterials for agriculture is relatively new as compared to their use in biomedical and industrial sectors. In order to promote sustainable nanoagriculture, biocompatible silver nanoparticles (AgNPs) have been synthesized through green route using kaffir lime leaf extract for use as nanopriming agent for enhancing seed germination of rice aged seeds. Results of various characterization techniques showed the successful formation of AgNPs which were capped with phytochemicals present in the plant extract...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810960/talk-to-the-hand-u-s-army-biophysical-testing
#6
William R Santee, Adam W Potter, Karl E Friedl
BACKGROUND: Many people are unaware of the science underlying the biophysical properties of Soldier clothing and personal protective equipment, yet there is a well-refined biomedical methodology initiated by Army physiologists in World War II. This involves a methodical progression of systematic material testing technologies, computer modeling, and human testing that enables more efficient development and rapid evaluation of new concepts for Soldier health and performance. Sophisticated manikins that sweat and move are a central part of this testing continuum...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28809092/particle-targeting-in-complex-biological-media
#7
REVIEW
Qiong Dai, Nadja Bertleff-Zieschang, Julia A Braunger, Mattias Björnmalm, Christina Cortez-Jugo, Frank Caruso
Over the past few decades, nanoengineered particles have gained increasing interest for applications in the biomedical realm, including diagnosis, imaging, and therapy. When functionalized with targeting ligands, these particles have the potential to interact with specific cells and tissues, and accumulate at desired target sites, reducing side effects and improve overall efficacy in applications such as vaccination and drug delivery. However, when targeted particles enter a complex biological environment, the adsorption of biomolecules and the formation of a surface coating (e...
August 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28806989/maximising-value-from-a-united-kingdom-biomedical-research-centre-study-protocol
#8
Trisha Greenhalgh, Pavel V Ovseiko, Nick Fahy, Sara Shaw, Polly Kerr, Alexander D Rushforth, Keith M Channon, Vasiliki Kiparoglou
BACKGROUND: Biomedical Research Centres (BRCs) are partnerships between healthcare organisations and universities in England. Their mission is to generate novel treatments, technologies, diagnostics and other interventions that increase the country's international competitiveness, to rapidly translate these innovations into benefits for patients, and to improve efficiency and reduce waste in healthcare. As NIHR Oxford BRC (Oxford BRC) enters its third 5-year funding period, we seek to (1) apply the evidence base on how best to support the various partnerships in this large, multi-stakeholder research system and (2) research how these partnerships play out in a new, ambitious programme of translational research...
August 14, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28804866/virally-vectored-vaccine-delivery-medical-needs-mechanisms-advantages-and-challenges
#9
Daniel D Pinschewer
Vaccines represent one of the most successful chapters in the history of medicine. Over the past decades, the advent of recombinant cDNA technology has enabled the biomedical community to genetically engineer viruses for vaccine delivery purposes. As a starting point, this review evaluates the unmet medical needs, which drive scientists and industry to exploit such fundamentally new technology for human vaccination. The author discusses the molecular functioning, production and safety profile of replication-competent and -deficient viral vector systems, representing two fundamentally distinct classes of "genetic vaccines"...
August 14, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28804798/probing-biological-redox-chemistry-with-large-amplitude-fourier-transformed-ac-voltammetry
#10
Hope Adamson, Alan M Bond, Alison Parkin
Biological electron-exchange reactions are fundamental to life on earth. Redox reactions underpin respiration, photosynthesis, molecular biosynthesis, cell signalling and protein folding. Chemical, biomedical and future energy technology developments are also inspired by these natural electron transfer processes. Further developments in techniques and data analysis are required to gain a deeper understanding of the redox biochemistry processes that power Nature. This review outlines the new insights gained from developing Fourier transformed ac voltammetry as a tool for protein film electrochemistry...
August 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28803753/recent-progresses-in-biomedical-applications-of-aptamer-functionalized-systems
#11
REVIEW
Fei Ding, Yangguang Gao, Xianran He
Aptamers, known as "chemical antibodies" are screened via a combinational technology of systematic evolution of ligands by exponential enrichment (SELEX). Due to their specific targeting ability, high binding affinity, low immunogenicity and easy modification, aptamer-functionalized systems have been extensively applied in various fields and exhibit favorable results. However, there is still a long way for them to be commercialized, and few aptamer-functionalized systems have yet successfully entered clinical and industrial use...
March 18, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28803469/chiral-ceramic-nanoparticles-of-tungsten-oxide-and-peptide-catalysis
#12
Shuang Jiang, Mahshid Chekini, Zhi-Bei Qu, Yichun Wang, Aydan Yeltik, Yuangang Liu, Alex Kotlyar, Tianyong Zhang, Bin Li, Hilmi Volkan Demir, Nicholas A Kotov
The chirality of nanoparticles (NPs) and their assemblies has been investigated predominantly for noble metals and II-VI semiconductors. However, ceramic NPs represent the majority of nanoscale materials in Nature. The robustness and other innate properties of ceramics offer technological opportunities in catalysis, biomedical sciences, and optics. Here we report the preparation of chiral ceramic NPs, as represented by tungsten oxide hydrate, WO3-x·H2O, dispersed in ethanol. The chirality of the metal oxide core, with an average size of ca 1...
August 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28802332/new-algorithms-for-processing-time-series-big-eeg-data-within-mobile-health-monitoring-systems
#13
Mohamed Adel Serhani, Mohamed El Menshawy, Abdelghani Benharref, Saad Harous, Alramzana Nujum Navaz
BACKGROUND AND OBJECTIVES: Recent advances in miniature biomedical sensors, mobile smartphones, wireless communications, and distributed computing technologies provide promising techniques for developing mobile health systems. Such systems are capable of monitoring epileptic seizures reliably, which are classified as chronic diseases. Three challenging issues raised in this context with regard to the transformation, compression, storage, and visualization of big data, which results from a continuous recording of epileptic seizures using mobile devices...
October 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28802101/flexible-biodegradable-citrate-based-polymeric-step-index-optical-fiber
#14
Dingying Shan, Chenji Zhang, Surge Kalaba, Nikhil Mehta, Gloria B Kim, Zhiwen Liu, Jian Yang
Implanting fiber optical waveguides into tissue or organs for light delivery and collection is among the most effective ways to overcome the issue of tissue turbidity, a long-standing obstacle for biomedical optical technologies. Here, we report a citrate-based material platform with engineerable opto-mechano-biological properties and demonstrate a new type of biodegradable, biocompatible, and low-loss step-index optical fiber for organ-scale light delivery and collection. By leveraging the rich designability and processibility of citrate-based biodegradable polymers, two exemplary biodegradable elastomers with a fine refractive index difference and yet matched mechanical properties and biodegradation profiles were developed...
August 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28798342/nanoparticle-based-plasmonic-transduction-for-modulation-of-electrically-excitable-cells
#15
Parveen Bazard, Robert D Frisina, Joseph P Walton, Venkat R Bhethanabotla
There is a compelling need for the development of new sensory and neural prosthetic devices which are capable of more precise point stimulation. Current prosthetic devices suffer from the limitation of low spatial resolution due to the non-specific stimulation characteristics of electrical stimulation, i.e., the spread of electric fields generated. We present a visible light stimulation method for modulating the firing patterns of electrically-excitable cells using surface plasmon resonance phenomena. In in-vitro studies using gold (Au) nanoparticle-coated nanoelectrodes, we show that this method (substrate coated with nanoparticles) has the potential for incorporating this new technology into neural stimulation prosthetics, such as cochlear implants for the deaf, with very high spatial resolution...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796634/nature-contact-and-human-health-a-research-agenda
#16
Howard Frumkin, Gregory N Bratman, Sara Jo Breslow, Bobby Cochran, Peter H Kahn, Joshua J Lawler, Phillip S Levin, Pooja S Tandon, Usha Varanasi, Kathleen L Wolf, Spencer A Wood
BACKGROUND: At a time of increasing disconnectedness from nature, scientific interest in the potential health benefits of nature contact has grown. Research in recent decades has yielded substantial evidence, but large gaps remain in our understanding. OBJECTIVES: We propose a research agenda on nature contact and health, identifying principal domains of research and key questions that, if answered, would provide the basis for evidence-based public health interventions...
July 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28795180/dual-responsive-deformation-of-a-crosslinked-liquid-crystal-polymer-film-with-complex-molecular-alignment
#17
Quan Liu, Yuanyuan Zhan, Jia Wei, Wei Ji, Wei Hu, Yanlei Yu
Crosslinked liquid crystal polymers (CLCPs) containing azobenzene mesogens have been developed as stimuli-responsive materials, which can undergo photodeformation and thus convert light energy into mechanical force. The deformation behavior of CLCPs is strongly influenced by the alignment of the mesogens; however, a precise control of the alignment domain at micro-scale is still a challenge. Here we report complex molecular alignment in the CLCP film by using photoalignment technology. First, azo dye SD1 is aligned in-plane by UV light with a discrete alternating striped director profile...
August 10, 2017: Soft Matter
https://www.readbyqxmd.com/read/28792675/cover-image-volume-118-number-10-october-2017
#18
Jiachen Lin, Yangzhong Zhou, Jiaqi Liu, Jia Chen, Weisheng Chen, Sen Zhao, Zhihong Wu, Nan Wu
Cover: The cover image, by Jiachen Lin et al., is based on the Prospects Article, Progress and Application of CRISPR/Cas Technology in Biological and Biomedical Investigation, DOI: 10.1002/jcb.26198.
October 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28783106/melanin-based-contrast-agents-for-biomedical-optoacoustic-imaging-and-theranostic-applications
#19
REVIEW
Dario Livio Longo, Rachele Stefania, Silvio Aime, Alexander Oraevsky
Optoacoustic imaging emerged in early 1990s as a new biomedical imaging technology that generates images by illuminating tissues with short laser pulses and detecting resulting ultrasound waves. This technique takes advantage of the spectroscopic approach to molecular imaging, and delivers high-resolution images in the depth of tissue. Resolution of the optoacoustic imaging is scalable, so that biomedical systems from cellular organelles to large organs can be visualized and, more importantly, characterized based on their optical absorption coefficient, which is proportional to the concentration of absorbing chromophores...
August 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28780997/electrochemical-carbon-based-nanosensors-a-promising-tool-in-pharmaceutical-and-biomedical-analysis
#20
REVIEW
Sevinc Kurbanoglu, Sibel A Ozkan
Nanotechnology has become very popular in the sensor fields in recent times. It is thought that the utilization of such technologies, as well as the use of nanosized materials, could well have beneficial effects for the performance of sensors. Nano-sized materials have been shown to have a number of novel and interesting physical and chemical properties. Low-dimensional nanometer-sized materials and systems have defined a new research area in condensed-matter physics within past decades. Apart from the aforesaid categories of materials, there exist various materials of different types for fabricating nanosensors...
June 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
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