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JOURNAL ARTICLE
Pavan K Bendapudi, Brody H Foy, Sarah B Mueller, Jun Liu, Louis M Feingold, Kristen E Burke, Wendy Cruz, Maria Y Chen, Emily S Lau, Rachel L Goldberg, Ishan Tatake, Shelby C Wilkinson, Brian J Carney, James R Stone, Doyun Park, Alzira R Avelino, Sajjad Hassan, Chester Andrzejewski, Kristen N Ruby, Kenneth D Friedman, Patricia A R Brunker, Rebecca K Leaf, John Higgins, Walter H Dzik, Jonathan A Stefely, Robert S Makar
In patients with immune thrombotic thrombocytopenic purpura (iTTP), autoantibodies against the metalloprotease ADAMTS13 lead to catastrophic microvascular thrombosis. However, the potential benefits of recombinant human ADAMTS13 (rADAMTS13) in patients with iTTP remain unknown. Here, we report the clinical use of rADAMTS13, which resulted in the rapid suppression of disease activity and complete recovery in a critically ill patient whose condition had proved to be refractory to all available treatments. We also show that rADAMTS13 causes immune complex formation, which saturates the autoantibody and may promote its clearance...
May 9, 2024: New England Journal of Medicine
#22
RANDOMIZED CONTROLLED TRIAL
Vincent Costalat, Tudor G Jovin, J F Albucher, Christophe Cognard, Hilde Henon, Nasreddine Nouri, Benjamin Gory, Sebastien Richard, Gaultier Marnat, Igor Sibon, Federico Di Maria, Mariam Annan, Grégoire Boulouis, Pere Cardona, Michael Obadia, Michel Piotin, Romain Bourcier, Benoit Guillon, Sophie Godard, Anne Pasco-Papon, Omer F Eker, Tae-Hee Cho, Guillaume Turc, Olivier Naggara, Stéphane Velasco, Matthias Lamy, Frédéric Clarençon, Sonia Alamowitch, Arturo Renu, Laurent Suissa, Hervé Brunel, Jean-Christophe Gentric, Serge Timsit, Chantal Lamy, Cyril Chivot, Francisco Macian-Montoro, Charbel Mounayer, Ozlem Ozkul-Wermester, Chrysanthi Papagiannaki, Valérie Wolff, Raoul Pop, Anna Ferrier, Emmanuel Chabert, Frédéric Ricolfi, Yannick Béjot, Elena Lopez-Cancio, Pedro Vega, Laurent Spelle, Christian Denier, Mònica Millán, Juan F Arenillas, Mikael Mazighi, Emmanuel Houdart, Maria Del Mar Freijo, Alain Duhamel, Nerses Sanossian, David S Liebeskind, Julien Labreuche, Bertrand Lapergue, Caroline Arquizan
BACKGROUND: The use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size has not been well studied. METHODS: We assigned, in a 1:1 ratio, patients with proximal cerebral vessel occlusion in the anterior circulation and a large infarct (as defined by an Alberta Stroke Program Early Computed Tomographic Score of ≤5; values range from 0 to 10) detected on magnetic resonance imaging or computed tomography within 6.5 hours after symptom onset to undergo endovascular thrombectomy and receive medical care (thrombectomy group) or to receive medical care alone (control group)...
May 9, 2024: New England Journal of Medicine
#23
JOURNAL ARTICLE
Shaoluan Zheng, Jia Feng, Zhiwei Chen, Chuanyuan Wei, Yuyan Pan, Jiaqi Liu
BACKGROUND: The role of high socioeconomic status (SES) as an established risk factor for melanoma has been well documented in Western countries and regions. However, research on the association between melanoma and SES in China remains limited. This study aimed to investigate the association between SES and melanoma incidence and stage in China. METHODS: Five measures of SES were accessed, including education level, ethnic background, per capita household income, occupation, and medical insurance coverage...
May 7, 2024: Annals of Plastic Surgery
#24
JOURNAL ARTICLE
Rushil R Dang, Jennifer An-Jou Lin, Shao-Yu Hung, Fu-Chan Wei
PURPOSE: This study aimed to evaluate quality of life (QOL) in patients with locally advanced oral cancer who underwent surgical resection followed by simultaneous double free flap reconstruction. METHODS: Institutional database was reviewed from 2015 to 2021 and prospectively collected University of Washington Quality of Life data that were extracted for patients who met the inclusion criteria. Mean, composite, and best percentage scores were computed. Wilcoxon signed rank test was used to analyze differences between groups...
May 7, 2024: Annals of Plastic Surgery
#25
JOURNAL ARTICLE
Gabriel Salum D'Alessandro, Alexandre Mendonça Munhoz, Fabiana Midori Takeuchi, Alejandro Povedano, João Carlos Sampaio Goes
BACKGROUND: About 30% to 50% of women with breast cancer undergo mastectomy, and approximately 50% of them will receive adjuvant radiotherapy (ART). This study evaluates the medium- and long-term impact of ART after immediate breast reconstruction (IBR) with latissimus dorsi myocutaneous (LDM) flap and silicone implants. METHODS: Clinical, surgical, and oncological data were retrospectively collected and analyzed based on the medical records of 176 patients who had undergone IBR with LDM flap and silicone implants...
May 7, 2024: Annals of Plastic Surgery
#26
JOURNAL ARTICLE
Sarut Chaisrisawadisuk, Aekachai Lauvalert, Vannipa Vathanophas, Nachasa Kongchu, Tara Vongviriyangkoon
BACKGROUND: Pierre Robin sequence (PRS), characterized by micrognathia, glossoptosis, cleft palate, and obstructed airways, is one of the craniofacial conditions challenging various approaches to managing compromised airways, ranging from conservative measures to invasive airway surgery. This study was conducted to identify predictive risk factors for tracheostomy in the PRS. METHODS: A retrospective chart review was conducted at a tertiary referral hospital in Thailand...
March 27, 2024: Annals of Plastic Surgery
#27
JOURNAL ARTICLE
Dominga Ladevig, Valentina Veloso, Camila Ávila-Oliver
INTRODUCTION: Trigeminal neuralgia is a painful neuropathic disorder characterized by sudden electric shock-like pain that significantly impacts patients' quality of life. Multiple treatment alternatives are available, including medical and surgical options but establishing the optimal course of action can be challenging. To enhance clinical decision-making for trigeminal neuralgia treatment, it is imperative to organize, describe and map the available systematic reviews and randomized trials...
May 8, 2024: Medwave
#28
JOURNAL ARTICLE
Paarth Kapadia, Andrew J Zimolzak, Divvy K Upadhyay, Saritha Korukonda, Riyaa Murugaesh Rekha, Umair Mushtaq, Usman Mir, Daniel R Murphy, Alexis Offner, Gary A Abel, Georgios Lyratzopoulos, Luke T A Mounce, Hardeep Singh
PURPOSE: Missed and delayed cancer diagnoses are common, harmful, and often preventable. Automated measures of quality of cancer diagnosis are lacking but could identify gaps and guide interventions. We developed and implemented a digital quality measure (dQM) of cancer emergency presentation (EP) using electronic health record databases of two health systems and characterized the measure's association with missed opportunities for diagnosis (MODs) and mortality. METHODS: On the basis of literature and expert input, we defined EP as a new cancer diagnosis within 30 days after emergency department or inpatient visit...
May 8, 2024: Journal of Clinical Oncology
#29
JOURNAL ARTICLE
Xiaoyan Meng, Yang Zheng, Lingfang Zhang, Peipei Liu, Zhonglong Liu, Yue He
Metabolic reprogramming is a hallmark of cancer. In addition to metabolic alterations in the tumor cells, multiple other metabolically active cell types in the tumor microenvironment (TME) contribute to the emergence of a tumor-specific metabolic milieu. Here, we defined the metabolic landscape of the TME during progression of head and neck squamous cell carcinoma (HNSCC) by performing single-cell RNA sequencing (scRNA-seq) on 26 human patient specimens, including normal tissue, pre-cancerous lesions, early-stage cancer, advanced-stage cancer, lymph node metastases, and recurrent tumors...
May 8, 2024: Cancer Research
#30
REVIEW
Ari J Rosenberg, Cesar A Perez, Wenji Guo, Jose Monteiro de Oliveira Novaes, Kamilla F Oliveira da Silva Reis, Patrick W McGarrah, Katharine A R Price
The treatment for recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) with immune checkpoint inhibitors (anti-PD1) with or without chemotherapy has led to an improvement in survival. Yet, despite this therapeutic advancement, only 15%-19% of patients remain alive at four years, highlighting the poor survival and unmet need for improved therapies for this patient population. Some of the key evolving novel therapeutics beyond anti-PD1 in R/M HNSCC have included therapeutic vaccine therapies, bispecific antibodies/fusion proteins and multitargeted kinase inhibitors, and antibody-drug conjugates (ADCs)...
June 2024: American Society of Clinical Oncology Educational Book
#31
JOURNAL ARTICLE
Melissa A Elafros, Alexanndra Brown, Huda Marcus, Thair Dawood, Ghassan I Bachuwa, Mousumi Banerjee, Peter J Winch, Michelle Kvalsund, Eva L Feldman, Lesli E Skolarus, Brian C Callaghan
BACKGROUND AND OBJECTIVES: Distal symmetric polyneuropathy (DSP) is a disabling, often painful condition associated with falls and reduced quality of life. Non-Hispanic Black people and people with low income are underrepresented in existing DSP studies; therefore, it is unknown whether data accurately reflect the prevalence, risk factors, and burden of disease in these populations. METHODS: Patients older than 40 years presenting to an outpatient internal medicine clinic predominantly serving Medicaid patients in Flint, Michigan, were enrolled in a cross-sectional study...
June 2024: Neurology
#32
EDITORIAL
Harshabad Singh, Ryan D Nipp
In this editorial accompanying manuscript the by Klatte and colleagues, Drs Singh, and Nipp review the data behind universal germline testing in pancreatic adenocarcinoma, and review possible reasons for and solutions continued inadequate rates of germline testing in our community. Making germline testing for all patients with pancreatic adenocarcinoma is critical and will require cross-disciplinary collaboration and innovation.
May 8, 2024: JCO oncology practice
#33
JOURNAL ARTICLE
Luisanna M Sánchez, Kerry Morrone, Melissa Frei-Jones, Titilope A Fasipe
Therapeutic options for sickle cell disease (SCD) have increased recently as well as the development of updated national guidelines. It is not known how these options are being offered or to what degree guidelines are incorporated into clinical practice. This study aimed to describe practice patterns for pediatric hematologists regarding the use of disease-modifying and potentially curative therapies for SCD. A 9-section, cross-sectional electronic survey was disseminated during a 3-month period via SurveyMonkey, to members of the American Society of Pediatric Hematology/Oncology Hemoglobinopathy Special Interest Group (ASPHO HSIG)...
May 7, 2024: Journal of Pediatric Hematology/oncology
#34
JOURNAL ARTICLE
Wenzhi He, Min Wang, Xuechun Zhang, Yilan Wang, Dongli Zhao, Wenhua Li, Fang Lei, Min Peng, Zhonglin Zhang, Yufeng Yuan, Zan Huang
Hepatocellular carcinoma (HCC) is an aggressive disease that occurs predominantly in men. Estrogen elicits protective effects against HCC development. Elucidation of the estrogen-regulated biological processes that suppress HCC could lead to improved prevention and treatment strategies. Here, we performed transcriptomic analyses on mouse and human liver cancer and identified LCAT as the most highly estrogen-upregulated gene and a biomarker of favorable prognosis. LCAT upregulation inhibited HCC in vitro and in vivo and mediated estrogen-induced suppression of HCC in an ESR1-dependent manner...
May 8, 2024: Cancer Research
#35
JOURNAL ARTICLE
Dandan Liu, Benliang Wei, Long Liang, Yue Sheng, Shengjie Sun, Xing Sun, Maohua Li, Haobo Li, Chaoying Yang, Yuanliang Peng, Yifang Xie, Chengcai Wen, Lu Chen, Xionghao Liu, Xiang Chen, Hong Liu, Jing Liu
Circadian clock perturbation frequently occurs in cancer and facilitates tumor progression by regulating malignant growth and shaping the immune microenvironment. Emerging evidence has indicated that clock genes are disrupted in melanoma and linked to immune escape. Here, we found that the expression of retinoic acid receptor-related orphan receptor-α (RORA) is downregulated in melanoma patients and that patients with higher RORA expression have a better prognosis after immunotherapy. Additionally, RORA was significantly positively correlated with T-cell infiltration and recruitment...
May 8, 2024: Cancer Research
#36
JOURNAL ARTICLE
Priyobrat Rajkhowa, Cauvery Kalyanpur, Rakshitha K, Viola Savy Dsouza, Sanjay Pattanshetty, Prakash Narayanan, Kavitha Saravu, Helmut Brand
The implementation of Human Papillomavirus (HPV) vaccination is crucial for eliminating cervical cancer in India. The infodemic, characterised by misleading information, could hinder the successful implementation of the initiative. Misinformation related to the HPV vaccine, such as rumours, has been reported and circulated, contributing to an alarming pattern of vaccine hesitancy observed on social media. This study aimed to identify the public sentiment towards HPV vaccination based on the 'Behavioral and Social Drivers (BeSD)' framework through geospatial, content and sentiment analysis...
January 2024: Global Public Health
#37
JOURNAL ARTICLE
Kishor Khanal, Juan A Pastor-Cervantes, Sunay Shah, Jianli Niu, Jonathan Roberts
OBJECTIVES: In the trans-radial era, arm venous access for right heart catheterization (RHC) is rising. Procedural success is affected by many factors, including subclavian/innominate vein stenosis (SVS) and pre-existing wires or catheters. In a study published previously by the same authors, 2% of cases had unsuccessful RHC through the arm, predominantly due to SVS. Since that study, techniques to improve RHC success rates have been developed, including crossing the stenosis with a coronary guidewire, followed by balloon dilatation...
May 7, 2024: Journal of Invasive Cardiology
#38
JOURNAL ARTICLE
Fiona Newlands, Celine Lewis, Anais d'Oelsnitz, Snehal M Pinto Pereira, Terence Stephenson, Trudie Chalder, Anna Coughtrey, Emma Dalrymple, Isobel Heyman, Anthony Harnden, Tamsin Ford, Shamez N Ladhani, Claire Powell, Kelsey McOwat, Rowan Bhopal, Jake Dudley, Paige Kolasinska, Mohammed Z Muhid, Manjula Nugawela, Natalia K Rojas, Angel Shittu, Ruth Simmons, Roz Shafran
Young people living with Long COVID are learning to navigate life with a constellation of poorly understood symptoms. Most qualitative studies on experiences living with Long COVID focus on adult populations. This study aimed to understand the experiences of young people living with Long COVID. Qualitative, semi-structured interviews were conducted ( n = 16); 11 young people (aged 13-19) and five parents were recruited from the Children and Young People with Long COVID (CLoCk) study ( n = 11) or its patient and public involvement and engagement (PPIE) group ( n = 5)...
May 8, 2024: Clinical Child Psychology and Psychiatry
#39
JOURNAL ARTICLE
Akira Mima, Yasuhiro Horii
OBJECTIVE: Tirzepatide is an injectable peptide approved by the US Food and Drug Administration for the treatment of Type 2 diabetes (T2DM). Its weight-loss effect primarily targets fat reduction; however, such effect on patients with chronic kidney disease (CKD) undergoing haemodialysis (HD) has not been reported. METHODS: Nine patients with CKD undergoing HD received weekly tirzepatide doses (2.5-7.5 mg) once a week. Evaluations encompassed tirzepatide's impact on dry weight (DW) and body composition assessed at baseline and study conclusion using bioelectrical impedance analysis...
May 2024: Endocrinology, Diabetes & Metabolism
#40
JOURNAL ARTICLE
Khaled Ibrahim, Dalal Thwood, Hajer ELgheriani, Mohamed Salem, Zaynab Elgadiym, Ahmed Zaghdani, Inas Alhudiri, Abdulraouf Habibi, Abdurrezagh Elfahem, Saadeddin Belaid, Otman Ermithi, Mahmoud Almaghrabi, Abubaker ELmaryul, Suad Almadah, Abdunnabi Rayes, Salah Edin El Meshri, Allaaeddin El Salabi, Adam Elzagheid
Among hospitalized patients worldwide, infections caused by multidrug-resistant (MDR) bacteria are a major cause of morbidity and mortality. This study aimed to isolate MDR bacteria from five intensive care units (ICUs) at Tripoli University Hospital (TUH). A prospective cross-sectional study was conducted over a seven-month period (September 2022 to March 2023) across five ICUs at TUH. A total of 197 swabs were collected from Patients', healthcare workers' and ICUs equipment. Samples collected from patients were nasal swabs, oral cavity swabs, hand swabs, sputum specimens, skin swabs, umbilical venous catheter swabs, and around cannula...
December 31, 2024: Libyan Journal of Medicine
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