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https://www.readbyqxmd.com/read/28449574/the-clinical-utilization-of-radiation-therapy-in-korea-between-2011-and-2015
#1
Young-Seok Seo, Mi-Sook Kim, Jin-Kyu Kang, Won-Il Jang, Hee Jin Kim, Chul Koo Cho, Hyung Jun Yoo, Eun Kyung Paik, Yu Jin Cha, Jae Sun Yoon
Purpose: The purpose of this study was to estimate the clinical utilization of radiation therapy (RT) in Korea between 2011 and 2015. Materials and Methods: We analyzed the claims data from the Health Insurance Review and Assessment Service (HIRA) to estimate the clinical utilization of RT. The source population consisted of all patients who had any of the International Classification of Diseases 10 (ICD-10) cancer diagnoses (C00-C97) and those with diagnostic codes D00-D48, who were also associated with at least one of the procedure codes related to RT...
April 25, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28449571/tardive-dyskinesia-associated-with-bupropion
#2
Taha Can Tuman, Uğur Çakır, Osman Yıldırım, Mehmet Akif Camkurt
Present report describes a 46 year old male patient with a diagnosis of major depression who developed tardive dyskinesia during bupropion therapy. Our patient had no history of neuroleptic use and his laboratory and neurologic examinations were normal. He had no family history of neurologic diseases. Although bupropion induced dyskinesia has been previously reported in the literature, it is rare and our case is the first case regarding tardive dyskinesia.
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449570/low-dose-clozapine-induced-seizure-a-case-report
#3
Abdullah Bolu, Süleyman Akarsu, Erdal Pan, Emre Aydemir, Taner Oznur
Seizures are believed to be a dose-dependent side effect of clozapine. In this case report, we describe a patient who had tonic-clonic seizures after using a low dose clozapine who did not have any seizure risk. The 29-year-old male patient had been followed-up with a diagnosis of schizophrenia for about 5 years. When using clozapine 200 mg/day he had a tonic-clonic seizure with bilateral diffuse epileptic activity in electroencephalography (EEG). In the literature, there are a few case reports about low-dose clozapine-induced seizure...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449569/baclofen-abuse-due-to-its-hypomanic-effect-in-patients-with-alcohol-dependence-and-comorbid-major-depressive-disorder
#4
Soumitra Ghosh, Dhrubajyoti Bhuyan
Baclofen is a gamma-aminobutyric acid type B receptor agonist used as an anti-craving agent for treatment of alcohol dependence. It has gained popularity in the recent times because it is well tolerated even in patients with hepatic impairments. Herein we are summarizing the latest literature about baclofen induced hypomania and are reporting a case of baclofen abuse because of its mood elevating property in a patient of alcohol dependence with comorbid major depressive disorder. Literature review and case study of a 36-year-old male with alcohol dependence with comorbid major depressive disorder was prescribed with tablet baclofen as an anti-craving agent along with antidepressant medicines...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449568/bilateral-pretibial-edema-associated-with-paliperidone-palmitate-long-acting-injectable-a-case-report
#5
Erdinc Cicek, Ismet Esra Cicek, Faruk Uguz
Peripheral edema is observed as an adverse effect of the usage of antipsychotics in the literature. This case report describes a 36-year-old female patient with the diagnosis of paranoid schizophrenia who presented with pretibial edema following initiation of long-acting injectable paliperidone palmitate. Pretibial edema developed within the second week of treatment and completely disappeared after its discontinuation.
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449567/dose-dependent-course-of-hyperprolactinemic-and-normoprolactinemic-galactorrhea-induced-by-venlafaxine
#6
Mehmet Akif Camkurt, Gizem Gülpamuk, Ebru Fındiklı, Rengin Elve
Venlafaxine is a serotonergic and noradrenergic reuptake inhibitor which is used for the treatment of depression. We report a case of galactorrhea in a patient with major depressive disorder after starting treatment with venlafaxine. In particular, we discuss the course of hyper and normoprolactinemic galactorrhea. We managed this side effect initially by dose reduction and further by switching to essitalopram. Physicians should be aware of endocrinologic side effects such as galactorrhea during the serotonin and noradrenaline reuptake inhibitor treatment...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449566/dose-trends-of-aripiprazole-from-2004-to-2014-in-psychiatric-inpatients-in-korea
#7
Young Sup Woo, In Hee Shim, Sang-Yeol Lee, Dae-Bo Lee, Moon-Doo Kim, Young-Eun Jung, Jonghun Lee, Seunghee Won, Duk-In Jon, Won-Myong Bahk
Objective: Although aripiprazole has been widely used to treat various psychiatric disorders, little is known about the adequate dosage for Asian patients in clinical practice. Hence, we evaluated the initial and maximum doses of aripiprazole from 2004 to 2014 to estimate the appropriate dosage for Korean psychiatric inpatients in clinical practice. Methods: In this retrospective study, we reviewed the medical records of patients who were hospitalized in five university hospitals in Korea from March 2004 to December 2014...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449565/effect-of-oxcarbazepine-on-serum-brain-derived-neurotrophic-factor-in-bipolar-mania-an-exploratory-study
#8
Rituparna Maiti, Biswa Ranjan Mishra, Jaseem Jowhar, Debadatta Mohapatra, Sansita Parida, Debasis Bisoi
Objective: In bipolar disorder, serum brain-derived neurotrophic factor (BDNF) level decreases leading to dysfunctions of critical neurotrophic, cellular plasticity and neuroprotective processes. The present study was conducted to evaluate the change in serum BDNF level with oxcarbazepine monotherapy in bipolar mania. Methods: The present study is a prospective, interventional, open label clinical study conducted on 25 patients of bipolar mania and 25 healthy controls...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449564/dehydroepiandrosterone-sulfate-level-varies-nonlinearly-with-symptom-severity-in-major-depressive-disorder
#9
Dasom Uh, Hyun-Ghang Jeong, Kwang-Yeon Choi, So-Young Oh, Suji Lee, Seung-Hyun Kim, Sook-Haeng Joe
Objective: The pathophysiology of major depressive disorder (MDD) is still not well understood. Conflicting results for surrogate. biomarkers in MDD have been reported, which might be a consequence of the heterogeneity of MDD patients. Therefore, we aim to investigate how the severity of depression and various symptom domains are related to the levels of dehydroepiandrosterone sulfate (DHEA-s) in MDD patients. Methods: We recruited 117 subjects from a general practice...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449563/relationship-between-serum-bilirubin-levels-and-metabolic-syndrome-in-patients-with-schizophrenia-spectrum-disorders
#10
Filiz Karadag, Ceyhan Balci Sengul, Yasar Enli, Kamuran Karakulah, Huseyin Alacam, Bunyamin Kaptanoglu, Ozgur Kalkanci, Hasan Herken
Objective: We investigated the relationship between serum bilirubin levels and metabolic syndrome (MetS), and the longitudinal effects of baseline serum bilirubin concentrations on MetS in patients with schizophrenia spectrum disorders undergoing atypical antipsychotics. Methods: The sample of this study consisted of 131 patients with schizophrenia spectrum disorders. Waist circumference, blood pressure, and levels of triglycerides, high-density lipoprotein cholesterol, fasting glucose, and insulin were evaluated at baseline and at month six...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449562/longer-telomere-length-of-t-lymphocytes-in-patients-with-early-and-chronic-psychosis
#11
Yin Cui, Vishwanath Vasudev Prabhu, Thong Ba Nguyen, Subramaniam Mohana Devi, Young-Chul Chung
Objective: To investigate pathological conditions that act as sources of pro-inflammatory cytokines and cytotoxic substances to examine telomere length (TL) in patients with either early (duration of illness [DI] ≤5 years) or chronic (DI >5 years) psychosis using T lymphocytes. Methods: Based on these factors and the important role that T lymphocytes play in inflammation, the present study measured the TL of T lymphocytes in patients with either early or chronic psychosis...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449560/assessment-of-the-latent-adverse-events-of-antipsychotic-treatment-using-a-subjective-questionnaire-in-japanese-patients-with-schizophrenia
#12
Masakazu Hatano, Hiroyuki Kamei, Azusa Kato, Ippei Takeuchi, Manako Hanya, Junji Uno, Shigeki Yamada, Kiyoshi Fujita, Nakao Iwata
Objective: The adverse effects of antipsychotic agents can have a marked influence on medication adherence. In this study, we. investigated the adverse events of antipsychotics that are less likely to be reported by patients and the reasons why such symptoms remain latent. Methods: Data were collected by interviewing patients using a subjective questionnaire, and the associations between unreported symptoms and background factors were investigated. Results: A total of 306 patients with schizophrenia or schizoaffective disorder were examined...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449559/effects-of-escitalopram-on-anxiety-in-patients-with-acute-coronary-syndrome-a-randomized-controlled-trial
#13
Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Jin-Sang Yoon, Jae-Min Kim
Objective: There are no evidence-based practices for treating anxiety in patients with acute coronary syndrome (ACS). Thus, we investigated the effects of escitalopram on anxiety in this population. Methods: We enrolled 217 patients with ACS who met Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for depressive disorders into a randomized double-blind placebo-controlled study. Patients received either escitalopram or placebo over a 24-week period...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449556/role-of-sleep-disturbance-in-the-trajectory-of-alzheimer-s-disease
#14
REVIEW
Dong Woo Kang, Chang Uk Lee, Hyun Kook Lim
Sleep disturbances such as insomnia, hypersomnia, and circadian rhythm disturbance are common in normal elderly and Alzheimer's disease (AD) patients. To date, special attention has been paid to sleep disturbance in the clinical course of AD insofar as the interaction of sleep disturbance with the pathogenesis of AD may impact the clinical course and cognitive function of AD patients. This review covers the bidirectional relationship between sleep disturbance and AD pathogenesis; the associations between sleep disturbance and AD-specific neurotransmitters, brain structure, and aspects of sleep disturbance in each phase of AD; and the effects of sleep disturbance on the cognitive functions of patients in each phase of AD...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449554/a-study-of-single-nucleotide-polymorphisms-of-tumour-necrosis-factor-%C3%AE-1031-and-tumour-necrosis-factor-%C3%AE-252-in-chronic-rhinosinusitis
#15
Khairunnisak Misron, Suzina Sheikh Ab Hamid, Azlina Ahmad, Ramiza Ramza Ramli
Objectives: This case-controlled study aimed to identify the association of tumor necrosis factor (TNF)α-1031 and TNFβ+252 gene polymorphisms between chronic rhinosinusitis (CRS) and healthy controls. Another purpose of this study was to investigate the associations of these gene polymorphisms with factors related to CRS. Methods: All deoxyribonucleic acid (DNA) samples were genotyped for TNFα-1031 and TNFβ+252 genes by mean of polymerase chain reaction (PCR) and restriction fragment length polymorphisms (RFLP)...
April 28, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28449553/changes-in-the-reflux-symptom-index-after-multilevel-surgery-for-obstructive-sleep-apnea
#16
Su Jin Kim, Hyo Yeol Kim, Jong In Jeong, Sang Duk Hong, Seung-Kyu Chung, Hun-Jong Dhong
Objectives: This study evaluated whether the symptoms of laryngopharyngeal reflux (LPR) change after multilevel surgery for obstructive sleep apnea (OSA). Methods: Patients who underwent multilevel surgery for OSA between April 2009 and September 2014 were enrolled in this study. All patients underwent preoperative polysomnography prior to surgery and were asked to complete the reflux symptom index (RSI) questionnaire before and after surgery. Results: Of 73 enrolled patients, 24 (33%) reported an RSI score >13 and were thus classified as having reflux...
April 28, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28449533/can-mathematics-replace-anatomy-to-establish-recommendations-in-lung-cancer-surgery
#17
EDITORIAL
Marc Riquet, Ciprian Pricopi, Antoine Legras, Alex Arame, Alain Badia, Françoise Le Pimpec Barthes
The greater the number of lymph node (LN) sampled (NLNsS) during lung cancer surgery, the lower the risk of underestimating the pN-status and the better the outcome of the pN0-patients due to stage-migration. Thus, regarding LN sampling "to be or not to be", number is the question. Recent studies advocate removing 10 LNs. The most suitable NLNsS is unfortunately impossible to establish by mathematics. A too high NLNsS variability exists, based on anatomy, surgery and pathology. The methodology may vary according to Inter-institutional differences in the surgical approach regarding LN inspection and number sampling...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449532/the-future-of-hybrid-ablation-an-emerging-need-for-an-anticoagulation-protocol-for-thoracoscopic-ablation
#18
EDITORIAL
Pavel Osmancik, Petr Budera
The midterm efficacy of hybrid ablation of atrial fibrillation (AF) reported in recent papers is about 70% in terms of sinus rhythm maintenance without antiarrhythmic drugs. Bearing in mind that the majority of patients enrolled are patients with persistent and long-standing persistent AF, the reported efficacies seem to be very good. Despite the high efficacies, safety remains a critical issue in hybrid, and especially thoracoscopic ablations. The frequency of complications during thoracoscopic ablations is more than 10% in the majority of reports...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449531/ablation-of-atrial-fibrillation-single-shot-techniques-poised-to-dominate-rhythm-control-strategies-the-future-is-here
#19
EDITORIAL
Antonis S Manolis
Over the recent years, the advent of single-shot techniques, such as circular catheter and cryoballoon ablation, has ushered in a new era in the catheter ablation approach and rhythm control strategies of patients with atrial fibrillation (AF). These techniques make it easier to navigate the heart and have the potential to decrease the threshold for, expand the access to, and increase patient and physician acceptance of rhythm-control therapies, that may lead to reduction of the AF disease burden and its socioeconomic impact...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449530/quality-improvement-in-the-icu-treat-first-what-kills-first
#20
EDITORIAL
Peter H J van der Voort
Professionals in the ICU, like nurses and doctors, are constantly working on quality improvement by developing protocols and monitoring the implementation with indicators. Protocols and quality indicators are usually based on evidence. Studies on quality improvement often measure the effect of protocols after implementation but frequently cannot replicate the results of the previously performed RCTs in clinical practice. Amongst other reasons, this is due to the selection of patients that are included in RCTs...
March 2017: Journal of Thoracic Disease
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