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https://www.readbyqxmd.com/read/28823144/factors-impacting-patient-cooperation-during-elective-gastroscopy
#1
Sang Pyo Lee, In-Kyung Sung, Jeong Hwan Kim, Sun-Young Lee, Hyung Seok Park, Chan Sup Shim
Background/Aims: Some people have difficulty tolerating upper endoscopy. The cause of and risk factors for this are not well known. The aim of this study was to investigate the factors involved in poor cooperation during screening upper endoscopy. Methods: A total of 4,422 subjects who underwent a health inspection with upper endoscopy carried out by a single experienced endoscopist were included. We retrospectively investigated subjects' self-reporting questionnaires and medical records, including endoscopic and histologic findings...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823142/oncogenes-mitochondrial-metabolism-and-quality-control-in-differentiated-thyroid-cancer
#2
Hyon-Seung Yi, Joon Young Chang, Koon Soon Kim, Minho Shong
Thyroid cancer is one of the most common malignancies of endocrine organs, and its incidence rate has increased steadily over the past several decades. Most differentiated thyroid tumors derived from thyroid epithelial cells exhibit slow-growing cancers, and patients with these tumors can achieve a good prognosis with surgical removal and radioiodine treatment. However, a small proportion of patients present with advanced thyroid cancer and are unusually resistant to current drug treatment modalities. Thyroid tumorigenesis is a complex process that is regulated by the activation of oncogenes, inactivation of tumor suppressors, and alterations in programmed cell death...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823141/targeted-therapy-of-ovarian-cancer-including-immune-check-point-inhibitor
#3
Jin Young Kim, Chi Heum Cho, Hong Suk Song
Epithelial ovarian cancer is the eighth most common cause of cancer-related deaths in women because most patients present with advanced stage disease at the time of diagnosis. Although cytoreductive surgery and platinum-based chemotherapy remain the gold standards of treatment, the recurrence rate of ovarian cancer remains high. Attempts to improve this standard two-drug chemotherapy by adding a third cytotoxic drug have failed to affect either progression-free survival or overall survival and have resulted in an increase in toxic side effects...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823140/pre-existing-arterial-pathologic-changes-affecting-arteriovenous-fistula-patency-and-cardiovascular-mortality-in-hemodialysis-patients
#4
Ja Young Lee, Young Ok Kim
The radiocephalic arteriovenous fistula (AVF) provides optimal vascular access for hemodialysis; it has a higher long-term patency rate and fewer complications than other vascular access methods. However, the AVF has a high primary failure rate. The presence of small-diameter vessels at anastomosis sites is an important risk factor for AVF failure. However, in a recent study, despite selecting an adequate artery and vein for creating an AVF by routine preoperative vascular mapping, AVF maturation and primary failure occurred...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823118/epidemiologic-characteristics-of-scrub-typhus-in-jeju-island-korea
#5
Sung Uk Lee
Purpose: Scrub typhus is the most common febrile disease in Autumn season. Jeju Island is the largest island in South Korea and has a distinctive oceanic climate. This study aimed to identify epidemiological characteristics of scrub typhus in Jeju. Methods: From January 2011 to December 2016, total 446 patients were diagnosed with scrub typhus in Jeju. Patient's personal and environmental factors that may relate to scrub typhus had been investigated and retrospectively analyzed...
August 18, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28823116/outcomes-of-living-donor-kidney-transplantation-in-diabetic-patients-age-and-sex-matched-comparison-with-non-diabetic-patients
#6
Chung Hee Baek, Hyosang Kim, Seung Don Baek, Mun Jang, Wonhak Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
Background/Aims: Kidney transplantation (KT) reportedly provides a significant survival advantage over dialysis in diabetic patients. However, KT outcome in diabetic patients compared with that in non-diabetic patients remains controversial. In addition, owing to recent improvements in the outcomes of KT and management of cardiovascular diseases, it is necessary to analyze outcomes of recently performed KT in diabetic patients. Methods: We reviewed all diabetic patients who received living donor KT between January 2008 and December 2011...
August 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823115/identification-of-distinctive-clinical-significance-in-hospitalized-patients-with-endoscopic-duodenal-mucosal-lesions
#7
Yeji Han, Hye-Kyung Jung, Ji Young Chang, Chang Mo Moon, Seong-Eun Kim, Ki-Nam Shim, Sung-Ae Jung, Joo-Young Kim, Ji-Yun Bae, Sae-In Kim, Ji-Hyun Lee, Sanghui Park
Background/Aims: Duodenitis is not infrequent finding in patient undergoing endoscopy. However, hospitalized patients have a higher incidence of secondary duodenal mucosal lesions that might be related with inflammatory bowel disease (IBD), cytomegalovirus (CMV) infection, tuberculosis, immunologic disorders, or other rare infections. We aimed to identify clinicopathologic features of duodenal mucosal lesions in hospitalized patients. Methods: All hospitalized patients having duodenal mucosal lesions were identified by endoscopic registration data and pathologic data query from 2011 to 2014...
August 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823114/prescription-pattern-of-urate-lowering-therapy-in-korean-gout-patients-data-from-the-national-health-claims-database
#8
Ji-Won Kim, Sang Gyu Kwak, Sung-Hoon Park
No abstract text is available yet for this article.
August 21, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823113/dual-mode-endomicroscopy-for-detection-of-epithelial-dysplasia-in-the-mouth-a-descriptive-pilot-study
#9
Nico Bodenschatz, Catherine F Poh, Sylvia Lam, Pierre Lane, Martial Guillaud, Calum E MacAulay
Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering...
August 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28823103/bariatric-surgery-is-accompanied-by-changes-in-extracellular-vesicle-associated-and-plasma-fatty-acid-binding-protein-4
#10
Justyna K Witczak, Thinzar Min, Sarah L Prior, Jeffrey W Stephens, Philip E James, Aled Rees
BACKGROUND: Bariatric surgery markedly reduces fat mass with beneficial effects on cardiometabolic health but the mechanisms involved are not fully understood. Extracellular vesicles (EVs) are secreted by a variety of cells, including adipocytes, and may mediate some of these benefits. However, the effects of bariatric surgery on circulating EVs are unclear. METHODS: Concentration of plasma EVs isolated by ultracentrifugation at baseline, 1 and 6 months post-bariatric surgery (n = 20) was established using Nanoparticle Tracking Analysis...
August 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28823102/the-etiology-of-primary-hyperhidrosis-a-systematic-review
#11
REVIEW
Moshe Hashmonai, Alan E P Cameron, Cliff P Connery, Noel Perin, Peter B Licht
PURPOSE: Primary hyperhidrosis is a pathological disorder of unknown etiology, affecting 0.6-5% of the population, and causing severe functional and social handicaps. As the etiology is unknown, it is not possible to treat the root cause. Recently some differences between affected and non-affected people have been reported. The aim of this review is to summarize these new etiological data. METHODS: Search of the literature was performed in the PubMed/Medline Database and pertinent articles were retrieved and reviewed...
August 19, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28823099/evidence-of-dysexecutive-syndrome-in-patients-with-acromegaly
#12
Shaobo Shan, Lingling Fang, Jia Huang, Raymond C K Chan, Guijun Jia, Weiqing Wan
PURPOSE: This study aimed to explore different aspects of executive function in patients with acromegaly and investigate the cause of dysexecutive syndrome in these patients. METHODS: We conducted five typical executive function tests (Stroop test, verbal fluency [VF] test, Hayling Sentence Completion Test [HSCT], N-back test, and Sustained Attention to Response Task [SART]) on 42 acromegalic patients and 42 strictly matched healthy controls. Comparative analyses were conducted for five major executive function domains...
August 19, 2017: Pituitary
https://www.readbyqxmd.com/read/28823090/epidural-patch-with-autologous-platelet-rich-plasma-a-novel-approach
#13
Berrin Gunaydin, Muberra Acar, Gokcen Emmez, Didem Akcali, Nil Tokgoz
We aimed to perform an epidural patch using platelet rich plasma (PRP), which has the potential to regenerate and heal tissues via degranulation of platelets, in a 34-year-old parturient suffering from persistent post-dural puncture headache (PDPH) after failed epidural blood patch (EBP). After her admission to our unit, we reconfirmed the clinical and radiologic diagnosis of PDPH. Cranial MRI with contrast showed diffuse pachymeningeal thickening and contrast enhancement with enlarged pituitary consistent with intracranial hypotension...
August 19, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28823077/comparison-of-physical-function-in-early-rheumatoid-arthritis-patients-treated-with-biologics-for-1%C3%A2-year-who-achieved-clinical-remission-or-low-disease-activity
#14
Yosuke Hattori, Daihei Kida, Atsushi Kaneko
This study aimed to evaluate whether targeting clinical remission is appropriate for suppressing physical dysfunction in patients with early rheumatoid arthritis (RA). Subjects were all 75 early RA patients (within 2 years of onset) who were continuously treated with biologics for 12 months at our hospital. We evaluated the Simplified Disease Activity Index (SDAI) and Disability Index of the Health Assessment Questionnaire (HAQ-DI) at 3, 6, and 12 months from the initiation of biologics therapy. Rates of functional remission (HAQ-DI ≤ 0...
August 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28823074/single-anastomosis-duodeno-ileal-switch-sadis-a-systematic-review-of-efficacy-and-safety
#15
Saeed Shoar, Lauren Poliakin, Rebecca Rubenstein, Alan A Saber
BACKGROUND: Owing to the possibility of weight regain after the long-term follow-up of gastric bypass patients and because of the high morbidity of biliopancreatic diversion with duodenal switch, single-anastomosis duodeno-ileal switch (SADIS) has emerged as a rescue procedure in bariatric surgery. OBJECTIVE: The purpose of this review is to summarize the literature data on SADIS. SETTING: University Hospital, NY. METHODS: A comprehensive literature review was performed through October 2016 to identify English studies on SADIS performed in human subjects...
August 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28823072/prevalence-and-predictors-of-digoxin-utilization-among-heart-failure-patients-with-reduced-ejection-fraction-in-qatar
#16
Alaa Abdullah Rahhal, Ahmed Awaisu, Kawthar M Tawengi, Safae AbuYousef, Lylia Mekideche
Background Digoxin is a cardiac glycoside that is recommended by clinical practice guidelines to be used in patients with heart failure with reduced ejection fraction (HFrEF) who still have persistent symptoms despite optimal medical therapy. However, this recommendation is based on limited and old trial data. Moreover, pharmacoepidemiologic studies are important in determining the prevalence of digoxin use and factors influencing this. Objective This study aimed to determine the prevalence and the predictors of digoxin utilization among patients with HFrEF with or without atrial fibrillation (AF) in Qatar...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823070/-what-is-not-written-does-not-exist-the-importance-of-proper-documentation-of-medication-use-history
#17
Carina Carvalho Silvestre, Lincoln Marques Cavalcante Santos, Alfredo Dias de Oliveira-Filho, Divaldo Pereira de Lyra
Medications are perceived as health risk factors, because they might cause damage if used improperly. In this context, an adequate assessment of medication use history should be encouraged, especially in transitions of care to avoid unintended medication discrepancies (UMDs). In a case-controlled study, we investigated potential risk factors for UMDs at hospital admission and found that 150 (42%) of the 358 patients evaluated had one or more UMDs. We were surprised to find that there was no record of a patient and/or relative interview on previous use of medication in 117 medical charts of adult patients (44...
August 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28823067/combined-classical-spindle-cell-pleomorphic-lipoma-spectrum-imaging-and-clinical-data
#18
Yara Younan, Anthony Martinez, Nickolas Reimer, Mark Edgar, Felix Gonzalez, Monica Umpierrez, Ty Subhawong, Adam D Singer
OBJECTIVES: Compile the largest study to date on the imaging and clinical features of the classic spindle cell/pleomorphic lipoma spectrum and suggest this diagnosis be included in the differential for benign and malignant macroscopic fat-containing soft tissue masses regardless of the mass location or patient demographics. MATERIALS AND METHODS: An institutional search was performed to identify all available classic-type spindle cell/pleomorphic lipomas with available demographic and imaging data...
August 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28823065/elevated-serum-estradiol-levels-in-artificial-autologous-frozen-embryo-transfer-cycles-negatively-impact-ongoing-pregnancy-and-live-birth-rates
#19
Rani Fritz, Sangita Jindal, Heather Feil, Erkan Buyuk
PURPOSE: The aim of this study is to evaluate the correlation between serum estradiol (E2) levels during artificial autologous frozen embryo transfer (FET) cycles and ongoing pregnancy/live birth rates (OP/LB). METHODS: A historical cohort study was conducted in an academic setting in order to correlate peak and average estradiol levels with ongoing pregnancy/live birth rates for all autologous artificial frozen embryo transfer cycles performed from 1/2011 to 12/2014...
August 19, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28823064/preoperative-hypoalbuminemia-is-an-independent-risk-factor-for-increased-high-grade-morbidity-after-elective-rectal-cancer-resection
#20
J Hardt, L Pilz, J Magdeburg, P Kienle, S Post, R Magdeburg
PURPOSE: This study investigated the association of preoperative hypoalbuminemia and postoperative complications after elective resection for rectal cancer. METHODS: From September 2009 to December 2014, all patients who underwent elective rectal resection for adenocarcinoma of the rectum were identified using a prospective colorectal cancer database. Hypoalbuminemia was defined as a serum albumin < 35 g/L. Characteristics and outcomes of hypoalbuminemic patients were compared to those of patients with normal albumin levels...
August 19, 2017: International Journal of Colorectal Disease
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