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Keywords Neuroendocrine tumor metastasi...

Neuroendocrine tumor metastasic treatment

https://read.qxmd.com/read/38399485/laryngeal-paraganglioma-a-case-report
#21
Dragos Octavian Palade, Florentina Severin, Daniela Vrinceanu, Razvan Hainarosie, Alma Maniu, Huzafa Ahmed, Felicia Manole, Florin Mocanu, Catalina Voiosu
Background and Objectives : Paragangliomas of the head and neck are rare neuroendocrine tumors originating from the paraganglia, which might be sympathetic or parasympathetic. Laryngeal paragangliomas are the rarest subtype of these tumors, with only 1.41% of all paragangliomas, arising from the supraglottic or subglottic paraganglia of the larynx. The vast majority of them are benign, but there are some cases in which they turn out to be malignant, and the only way to know with certainty the difference between them is when we identify distant metastases...
January 24, 2024: Medicina
https://read.qxmd.com/read/38397981/diagnostic-and-therapeutic-management-of-primary-orbital-neuroendocrine-tumors-nets-systematic-literature-review-and-clinical-case-presentation
#22
REVIEW
Giulia Arrivi, Monia Specchia, Emanuela Pilozzi, Maria Rinzivillo, Damiano Caruso, Curzio Santangeli, Daniela Prosperi, Anna Maria Ascolese, Francesco Panzuto, Federica Mazzuca
BACKGROUND: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. METHODS: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical-pathological features, diagnosis and therapeutic management...
February 6, 2024: Biomedicines
https://read.qxmd.com/read/38396713/does-telotristat-have-a-role-in-preventing-carcinoid-heart-disease
#23
JOURNAL ARTICLE
Aura D Herrera-Martínez, Antonio C Fuentes-Fayos, Rafael Sanchez-Sanchez, Antonio J Montero, André Sarmento-Cabral, María A Gálvez-Moreno, Manuel D Gahete, Raúl M Luque
Carcinoid heart disease (CHD) is a frequent and life-threatening complication in patients with carcinoid tumors. Its clinical management is challenging is some cases since serotonin-induced valve fibrosis leads to heart failure. Telotristat is an inhibitor of tryptophan-hydroxylase (TPH), a key enzyme in serotonin production. Telotristat use in patients with carcinoid syndrome and uncontrollable diarrhea under somatostatin analogs is approved, but its specific role in patients with CHD is still not clear. IN this context, we aimed to explore the effect of telotristat in heart fibrosis using a mouse model of serotonin-secreting metastasized neuroendocrine neoplasm (NEN)...
February 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38384807/transcatheter-arterial-chemoembolization-of-apatinib-and-camrelizumab-shr1210-against-liver-metastasis-from-hepatic-neuroendocrine-tumor-a-case-report
#24
Ruobing Qi, Wenhua Yang, Sixian Zhu, Jie Mao, Bei Yang, Anhui Xu, Qiang Fu
In this case report, we present the case of a 46-year-old woman with a hepatic neuroendocrine tumor (NET G2)-induced liver metastases. Initially, the left lateral lobectomy of the liver was performed. The post-operative pathological examination revealed NET G2, leading to the post-operative recovery with a general review. Further, the re-examination of liver magnetic resonance imaging (MRI) showed post-operative changes in the tumor of the left lateral lobe, with multiple liver masses and possible metastasis...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38383872/peritoneal-dissemination-of-appendiceal-goblet-cell-adenocarcinoma-mimicking-white-pus-caused-by-peritonitis-following-appendicitis-an-instructive-case-report
#25
JOURNAL ARTICLE
Keigo Nakashima, Masakazu Hashimoto, Yoshihito Kitamura, Makoto Shinohara, Mizuki Yamaguchi, Michinori Hamaoka, Masashi Miguchi, Toshihiro Misumi, Nobuaki Fujikuni, Satoshi Ikeda, Yasuhiro Matsugu, Takashi Nishisaka, Hideki Nakahara
BACKGROUND: Goblet cell adenocarcinoma is an extremely rare tumor in which the same cells exhibit both mucinous and neuroendocrine differentiation. It is considered more aggressive compared to conventional carcinoids and more likely to cause metastasis. CASE PRESENTATION: We report a case of goblet cell adenocarcinoma with peritoneal metastases. A 62-year-old man underwent appendectomy for acute appendicitis. Intraoperatively, inflammatory white pus and a small amount of dirty ascites were observed in the lower abdomen with severely inflamed appendix...
February 22, 2024: Surgical Case Reports
https://read.qxmd.com/read/38357684/experience-and-lessons-learned-in-the-treatment-of-transforming-small-cell-neuroendocrine-carcinoma-of-the-prostate-a-case-report-and-literature-review
#26
Binbin Song, Yan Luo, Qing Li, Hong Pan, Dong Li
INTRODUCTION: Small cell neuroendocrine carcinoma of the prostate (SCNECP) is a rare and highly malignant tumor that commonly transforms into conventional prostate adenocarcinoma (CPAC). Most of SCNECP cases cannot be detected and diagnosed early, and SCNECP is often diagnosed when there is liver and lung metastasis. Therefore, the early detection of the process from CPAC to SCNECP is crucial. CASE REPORT: We present a case of a 73-year-old man who was initially admitted to our hospital with metastatic CPAC...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38353868/pathological-complete-response-of-initially-unresectable-multiple-liver-metastases-achieved-using-combined-peptide-receptor-radionuclide-therapy-and-somatostatin-analogs-following-pancreatic-neuroendocrine-tumor-resection-a-case-report
#27
JOURNAL ARTICLE
Ryosuke Umino, Satoshi Nara, Noritoshi Kobayashi, Takahiro Mizui, Takeshi Takamoto, Daisuke Ban, Minoru Esaki, Nobuyoshi Hiraoka, Kazuaki Shimada
BACKGROUND: Peptide receptor radionuclide therapy (PRRT) serves as a novel and effective treatment option for somatostatin receptor-positive unresectable liver metastases of pancreatic neuroendocrine tumors (PNETs). However, there are few reported cases of surgical resection for initially unresectable liver metastases of PNET that were converted to resectable after PRRT. Here we report a case where PRRT and somatostatin analogs (SSAs) led to a pathological complete response of initially unresectable multiple liver metastases following PNET resection...
February 14, 2024: Surgical Case Reports
https://read.qxmd.com/read/38352716/cutaneous-neuroendocrine-metastases-of-visceral-origin-responsive-to-surgical-resection-and-targeted-radionuclide-therapy
#28
Eleanor Tung-Hahn, Ghassan El-Haddad, Jonathan Strosberg
Neuroendocrine neoplasms (NENs) encompass a diverse range of biologically and behaviorally distinct epithelial malignancies that derive from neuroendocrine cells. These neoplasms are able to secrete a variety of bioactive amines or peptide hormones. The majority of NENs are well-differentiated and are defined as neuroendocrine tumors (NETs). While NETs are known to frequently metastasize to lymph nodes, liver, and lungs, spread to the skin is extremely rare and is often a late finding. Because cutaneous metastasis from a visceral site represents distant tumor dissemination, prompt histologic diagnosis is critical in terms of selecting further treatment options and ultimately impacts subsequent prognosis...
2024: Case Reports in Dermatological Medicine
https://read.qxmd.com/read/38351767/a-rare-case-of-recurrent-mediastinal-malignant-paraganglioma-of-thyroid-origin-a-case-report
#29
JOURNAL ARTICLE
Georgi Yankov, Magdalena Alexieva, Silvia Ivanova, Nikolay Yanev
Paraganglioma is a neuroendocrine tumor that originates from extraadrenal chromaffin cells. Primary thyroid paraganglioma is an extremely rare neoplasm. In this study, an exceptionally uncommon case of recurrent mediastinal malignant paraganglioma with primary origin from thyroid gland is presented. Median resternotomy, resection of left brachiocephalic vein, and extirpation of the mediastinal tumor were performed successfully. Commonly, it is preoperatively misdiagnosed and has unpredictable biological behavior...
October 31, 2023: Folia Medica
https://read.qxmd.com/read/38322359/unexpected-pancreatic-mixed-neuroendocrine-nonneuroendocrine-neoplasms-minen-reflection-on-a-case-report
#30
Catarina Alexandra Quintas Baía, Alexandre Sousa, Fernanda Sousa, Pedro Santos, Ana Isabel Varelas, Luís Pedro Afonso, Joana Monteiro, José Manuel Fernandes, Lúcio Lara Santos, Joaquim Abreu de Sousa
The authors present a case involving a 51-year-old male who was diagnosed with a 4-cm mass in the body of the pancreas, initially suspected to be a ductal adenocarcinoma due to an elevated Ca 19.9 during routine analysis. Subsequent imaging studies confirmed a resectable disease without suspicious lymph nodes or distant metastasis, leading to the proposal of surgery. The patient underwent a laparoscopic distal splenopancreatectomy, which was uneventful. The histopathological examination revealed a 3.7-cm pancreatic mixed neuroendocrine neoplasia (MiNEN) with a predominant high-grade ductal adenocarcinoma component and a concurrent high-grade neuroendocrine carcinoma, with negative margins...
February 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38313961/large-cell-neuroendocrine-carcinoma-presenting-as-adult-intussusception
#31
John O Agboola, Hagar Attia, Li Zhonghua, Meredith Pittman
Large cell neuroendocrine carcinoma (LCNEC) is an extremely rare malignant tumor of the colon, presenting with more severe clinical outcomes in comparison to colonic adenocarcinoma. There are very few reported cases in the literature. We hereby add our voice to the incidence of this disease by presenting the first report of a patient with ileocolic intussusception secondary to a large cell neuroendocrine cancer of the cecum. The patient was a 48-year-old woman who presented with acute onset of generalized abdominal pain and leukocytosis...
January 2024: Curēus
https://read.qxmd.com/read/38311516/hepatic-cytoreduction-for-lung-and-renal-neuroendocrine-tumor-metastases
#32
JOURNAL ARTICLE
Kathryn Fowler, Janet Li, Rodney F Pommier
BACKGROUND: Patients with hepatic metastases from lung and renal neuroendocrine tumors are rare. Outcome data on treatment of hepatic metastases for these types of tumors are lacking. We report the outcomes of hepatic cytoreduction operations for these tumors. METHODS: Records of patients undergoing hepatic cytoreduction operations of at least 70 ​% of the hepatic tumors for well differentiated lung and renal neuroendocrine tumors were reviewed. Data collected included primary tumor type, number and size of metastases resected, tumor grade, percentage of hepatic cytoreduction, presence of extra-hepatic disease, and status at last follow up...
February 1, 2024: American Journal of Surgery
https://read.qxmd.com/read/38297984/neuroendocrine-carcinoma-of-the-uterine-cervix-with-extensive-pagetoid-spread-pattern
#33
Azusa Sakurai, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Sachiko Minamiguchi, Masaki Mandai
There have been no reported cases of neuroendocrine carcinoma (NEC) of the cervix with pagetoid spread (Pag-S). A 44-year-old woman came to our department because of abnormal cytology that persisted immediately after a radical hysterectomy for NEC of the cervix. A mapping biopsy in a large area from the vaginal wall to the vulva revealed that synaptophysin/Ki-67-positive tumor cells were scattered within the epithelium in multiple areas, suggesting a wide Pag-S of NEC. Because tumor cells were found beyond the vaginal wall, the anterior pelvic exenteration was performed...
January 31, 2024: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/38286653/metastatic-potential-of-t1a-and-t1b-non-small-cell-lung-cancer-analysis-in-the-czech-population
#34
JOURNAL ARTICLE
L Tulinský, M Kepičová, M Mitták, L Martínek
INTRODUCTION: Lung cancer is the most common cause of cancer death in the Czech Republic, in part due to its significant metastatic potential. The aim of this study was to collect real data on the metastatic potential and clinical characteristics of T1a and T1b lung cancer in the Czech population and to investigate potential factors that would predict an increased risk of lymph node metastasis. METHODS: Prospective-retrospective study conducted at the Department of Surgery of the University Hospital Ostrava during the period from January 1, 2015, to July 31, 2022...
2024: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://read.qxmd.com/read/38283504/the-evaluation-and-treatment-of-merkel-cell-carcinoma-and-brain-metastasis-a-case-report-and-review-of-the-literature
#35
Petr Gaburak, Taylor A Brown, Alexander J Pursel, Luis Cardenas Contreras, Michael Chun
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor associated with high mortality if metastases are identified. Currently, there is no standardized nor curative treatment for neurometastatic MCC. In this study, we have reviewed the more recent cases and the use of immunotherapy in a population. In this case report and review, we present a case of MCC with brain metastasis currently undergoing treatment with immunotherapy (pembrolizumab) resulting in an initial complete response with a progression-free survival time of five months...
December 2023: Curēus
https://read.qxmd.com/read/38273024/synthetic-lethal-combination-of-chk1-and-wee1-inhibition-for-treatment-of-castration-resistant-prostate-cancer
#36
JOURNAL ARTICLE
Yapeng Chao, Yuzhou Chen, Wenxiao Zheng, Kathryn Demanelis, Yu Liu, Jaclyn A Connelly, Hong Wang, Song Li, Qiming Jane Wang
WEE1 and CHEK1 (CHK1) kinases are critical regulators of the G2/M cell cycle checkpoint and DNA damage response pathways. The WEE1 inhibitor AZD1775 and the CHK1 inhibitor SRA737 are in clinical trials for various cancers, but have not been thoroughly examined in prostate cancer, particularly castration-resistant (CRPC) and neuroendocrine prostate cancers (NEPC). Our data demonstrated elevated WEE1 and CHK1 expressions in CRPC and NEPC cell lines and patient samples. AZD1775 resulted in rapid and potent cell killing with comparable IC50s across different prostate cancer cell lines, while SRA737 displayed time-dependent progressive cell killing with 10- to 20-fold differences in IC50s...
January 25, 2024: Oncogene
https://read.qxmd.com/read/38254794/influence-of-lymphatic-microvascular-and-perineural-invasion-on-oncological-outcome-in-patients-with-neuroendocrine-tumors-of-the-small-intestine
#37
JOURNAL ARTICLE
Frederike Butz, Agata Dukaczewska, Catarina Alisa Kunze, Janina Maren Krömer, Lisa Reinhard, Henning Jann, Uli Fehrenbach, Charlotte Friederieke Müller-Debus, Tatiana Skachko, Johann Pratschke, Peter E Goretzki, Martina T Mogl, Eva Maria Dobrindt
For the histopathological work-up of resected neuroendocrine tumors of the small intestine (siNET), the determination of lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already been demonstrated in many tumor entities. However, the influence of LI, VI and PnI in siNET has not been sufficiently described yet. A retrospective analysis of all patients treated for siNET at the ENETS Center of Excellence Charité-Universitätsmedizin Berlin, from 2010 to 2020 was performed ( n = 510)...
January 11, 2024: Cancers
https://read.qxmd.com/read/38244615/differentiated-high-grade-thyroid-carcinomas-diagnostic-consideration-and-clinical-features
#38
JOURNAL ARTICLE
I Tondi Resta, M A Gubbiotti, K T Montone, V A Livolsi, Z W Baloch
BACKGROUND: Differentiated high-grade thyroid carcinomas (DHGTCs) are a new diagnostic entity most recently defined in the 2022 World Health Organization's (WHO) Classification of Endocrine and Neuroendocrine Tumors. This new entity has been minimally described in the literature, and additional cases classified as such are missing. MATERIALS AND METHODS: Cases of DHGTCs diagnosed at our institution from 2012 to 2022 were identified, and the following were reviewed: cytologic and histologic diagnoses, ancillary testing, immunohistochemical staining, treatments, and patient outcomes...
February 2024: Human Pathology
https://read.qxmd.com/read/38244178/two-cases-of-pancreatic-neuroendocrine-tumors-with-ectopic-acth-syndrome-during-their-disease-course
#39
JOURNAL ARTICLE
Masatoshi Murakami, Keisuke Hirahata, Nao Fujimori, Takeo Yamamoto, Yoshinao Oda, Shingo Kozono, Keijiro Ueda, Testuhide Ito, Masafumi Nakamura, Yoshihiro Ogawa
Pancreatic neuroendocrine tumors (PanNETs) are rare malignant tumors that occur in the pancreas. They are divided into functioning and non-functioning tumors based on the presence or absence of their specific hormonal hyper-expression symptoms. Adrenocorticotropic hormone (ACTH)-producing PanNETs are rare, functional tumors, and their clinical characteristics and outcomes have not been well reported.Here, we report the cases of two patients with PanNETs who presented with ectopic ACTH syndrome (EAS) during the course of their disease...
January 20, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38224445/thyroid-gland-a-rare-site-of-metastasis
#40
JOURNAL ARTICLE
Ana María Orlandi, Graciela Alcaraz, Laila Bielski, Gabriela Brenta, Lorena Castro Jozami, Andrea Cavallo, Jorgelina Guerra, Santiago Zund
PURPOSE: Despite its rich vascularity, metastasis (MTS) to the thyroid tissue is unusual, ranging from 1 to 3%. This entity is not usually considered as differential diagnosis and is not included in the upfront approach in patients with thyroid nodules. Once diagnosed, treatment is controversial. The aim of this study was to evaluate diagnosis, treatment, and outcome at the end of follow-up in patients with a diagnosis of MTS to the thyroid. METHODS: A retrospective multicenter study was designed from 1985 to 2022; 29 patients with MTS to the thyroid gland were included in the analysis...
January 15, 2024: Endocrine
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