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Neuroendocrine tumor metastasic treatment

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https://www.readbyqxmd.com/read/29790179/merkel-cell-carcinoma-clinical-outcome-and-prognostic-factors-in-351-patients
#1
Linde M van Veenendaal, Alexander C J van Akkooi, Cees Verhoef, Dirk Jan Grünhagen, W Martin C Klop, Gerlof D Valk, Margot E T Tesselaar
BACKGROUND: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine carcinoma of the skin. AIM: To describe clinical outcome and prognostic factors of MCC patients in two expert-centers. METHOD: Patients with histologically confirmed MCC in 1990-2014 were included. Data on patient, tumor characteristics and treatment were retrospectively collected. RESULTS: A total of 351 Patients were evaluated, 153 (44%) males, median age 74 years (range 28-94)...
May 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29789972/recurrence-of-pancreatic-neuroendocrine-tumors-and-survival-predicted-by-ki67
#2
C G Genç, M Falconi, S Partelli, F Muffatti, S van Eeden, C Doglioni, H J Klümpen, C H J van Eijck, E J M Nieveen van Dijkum
BACKGROUND: Despite evidence of different malignant potentials, postoperative follow-up assessment is similar for G1 and G2 pancreatic neuroendocrine tumors (panNETs) and adjuvant treatment currently is not indicated. This study investigated the role of Ki67 with regard to recurrence and survival after curative resection of panNET. METHODS: Patients with resected non-functioning panNET diagnosed between 1992 and 2016 from three institutions were retrospectively analyzed...
May 22, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29780727/bronchial-carcinoid-in-anomalous-right-upper-bronchus-a-patient-tailored-bronchoplasty-resection-technique
#3
Francesco Petrella, Alessio Vincenzo Mariolo, Juliana Guarize, Stefano Donghi, Lara Girelli, Stefania Rizzo, Lorenzo Spaggiari
Bronchial carcinoids (BC) are indolent neuroendocrine tumors (NET) that are classified as malignant because they can locally infiltrate and metastasize. Resection is the primary treatment for most localized carcinoid tumors, with lung parenchymal-sparing surgery the favoured objective for patients with central airway tumors. Sleeve bronchoplasty techniques are complex surgical procedures defined as parenchyma-saving because they allow a radical resection with tumor-free margins while preserving the maximum amount of parenchyma...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29746336/resection-of-the-primary-gastrointestinal-neuroendocrine-tumor-improves-survival-with-or-without-liver-treatment
#4
Aaron Lewis, Mustafa Raoof, Philip H G Ituarte, John Williams, Laleh Melstrom, Daneng Li, Byrne Lee, Gagandeep Singh
OBJECTIVE: The aim of this study was to determine outcomes of primary tumor resection in metastatic neuroendocrine tumors across all primary tumor sites. BACKGROUND: Primary tumor resection (PTR) may offer a survival benefit in metastatic gastrointestinal neuroendocrine tumors (GI-NETs); however, few studies have examined the effect of primary site and grade on resection and survival. METHODS: This is a retrospective study of patients with metastatic GI-NETs at presentation between 2005 and 2011 using the California Cancer Registry (CCR) dataset merged with California Office of Statewide Health Planning and Development (OSHPD) inpatient longitudinal database...
May 9, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29741203/peptide-receptor-radionuclide-therapy-for-advanced-gastroenteropancreatic-neuroendocrine-tumors-from-oncology-perspective
#5
Agnieszka Kolasińska-Ćwikła, Anna Łowczak, Katarzyna Maciejkiewicz Maciejkiewicz, Jarosław Bogdan Ćwikła
Peptide Receptor Radionuclide Therapy (PRRT) is a form of molecular targeted therapy which is performed by using a small peptide (somatostatin analogue - SSA) that is coupled with a radionuclide beta emitting radiation. PRRT is a nuclear medicine for the systemic treatment of non-resectable, metastasized well/moderately differentiated, neuroendocrine tumours (NET) with overexpression of somatostatin receptor. These types of tumours include gastroenteropancreatic neoplasm (GEP-NENs), e.g. arising from the small bowel (often called carcinoid tumours), the pancreas, duodenum or stomach, but also from the large bowel or the lung and many other tissues (so called diffuse neuroendocrine system)...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29733523/pattern-and-risk-factors-for-distant-metastases-in-gastrointestinal-neuroendocrine-neoplasms-a-population-based-study
#6
Wen Cai, Yinuo Tan, Weiting Ge, Kefeng Ding, Hanguang Hu
An increased incidence of gastrointestinal neuroendocrine neoplasms (GI-NENs) has been reported worldwide, and metastasis is the leading cause of GI-NEN-related death. Studies of different metastatic patterns in patients with different primary sites are limited. A population-based retrospective cohort study was conducted with the Surveillance, Epidemiology, and End Results (SEER) database. Patients with a GI-NEN diagnosis between 2010 and 2014 were included. All statistical analyses were performed using Intercooled Stata 12...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29731245/the-prognostic-impact-of-primary-tumor-resection-in-pancreatic-neuroendocrine-tumors-with-synchronous-multifocal-liver-metastases
#7
Chen Lin, Hongmei Dai, Xiafei Hong, Haiyu Pang, Xianze Wang, Peiran Xu, Jialin Jiang, Wenming Wu, Yupei Zhao
BACKGROUND: Whether primary tumor resection benefits patients with synchronous multifocal liver metastases from pancreatic neuroendocrine tumors remains controversial. We investigated whether primary tumor resection significantly affects survival in this study. METHODS: A retrospective study of patients with synchronous multifocal liver metastases from pancreatic neuroendocrine tumors between 1998 and 2016 was performed. Patient demographics, operation details, adjuvant treatment, and pathological and survival information were collected, and relevant clinical-pathological parameters were assessed in univariate and multivariate survival analyses...
April 30, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29724520/long-term-toxicity-after-transarterial-radioembolization-with-yttrium-90-using-resin-microspheres-for-neuroendocrine-tumor-liver-metastases
#8
Yuki Tomozawa, Younes Jahangiri, Priya Pathak, Kenneth J Kolbeck, Ryan C Schenning, John A Kaufman, Khashayar Farsad
PURPOSE: To evaluate long-term effects of yttrium-90 (90 Y) transarterial radioembolization (TARE) for unresectable hepatic metastases of neuroendocrine tumors (NETs). MATERIALS AND METHODS: Retrospective analysis of 93 patients (47 women, 46 men; mean age 59 y) who underwent resin-based 90 Y TARE was performed. Variables associated with overall survival were analyzed using univariate and multivariate models. Changes in serologic values and imaging characteristics were assessed with long-term follow-up...
April 30, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29696624/therapeutic-targeting-of-tumor-associated-macrophages-in-pancreatic-neuroendocrine-tumors
#9
Sebastian Krug, Rami Abbassi, Heidi Griesmann, Bence Sipos, Dominik Wiese, Peter Rexin, Annika Blank, Aurel Perren, Johannes Haybaeck, Stefan Hüttelmaier, Anja Rinke, Thomas M Gress, Patrick Michl
Pancreatic neuroendocrine tumors (PNETs) represent a heterogeneous group of neuroendocrine neoplasms with varying biological behaviour and response to treatment. Although targeted therapies have been shown to improve the survival for patients at advanced stage, resistance to current therapies frequently occurs during the course of therapy. Previous reports indicate that the infiltration of tumor-associated macrophages (TAMs) in PNETs might correlate with tumor progression and metastasis formation. We aimed to evaluate the prognostic and functional impact of TAMs in human PNETs in vitro and in vivo and to investigate the effect of therapeutic targeting TAMs in a genetic PNET mouse model...
April 26, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29696066/metastatic-neuroendocrine-pancreatic-tumor-case-report
#10
E C Radu, A I Saizu, R R Grigorescu, A E Croitoru, C Gheorghe
Rationale. Pancreatic neuroendocrine tumors (NETs) are rare neoplasms that develop from the endocrine tissues of the pancreas. They have a better overall prognosis than pancreatic adenocarcinoma. However, all commonly used classification systems reflect a separation between more indolent, well-differentiated tumors and far more aggressive poorly differentiated types that behave clinically more like small-cell carcinoma of the lung. Objective. To present the case of a 62-year-old man with an aggressive pancreatic NET, with liver, splenic and bone metastases who underwent multidisciplinary treatment including several lines of chemotherapy, somatostatin analogs and radiotherapy...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29690667/-clinicopathologic-characterisitics-of-pancreatic-acinar-cell-carcinomas
#11
X H Ding, Z B Wang, X M Qiu
Objective: To investigate clinical, pathological and immunohistochemical features of pancreatic acinar cell carcinoma. Methods: A retrospective review of surgical and pathological databases between 2011 and 2016 at PLA General Hospital was collected and 14 cases of acinar cell carcinoma (ACC) of the pancreas were identified. EnVision immunohistochemistry was used to detect the expression of Trypsin, bcl-10 and cytokeratin(CK) proteins. Results: The patients included nine cases of pure ACC, 3 cases of mixed acinar ductal carcinoma, 1 case of mixed acinar-neuroendocrine carcinoma and acinar-ductal-neuroendocrine carcinoma, respectively...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29689572/endoscopic-ultrasound-elastography-of-small-solid-pancreatic-lesions-a-multicenter-study
#12
Andre Ignee, Christian Jenssen, Paolo G Arcidiacono, Michael Hocke, Kathleen Möller, Adrian Saftoiu, Uwe Will, Pietro Fusaroli, Julio Iglesias-Garcia, Ryan Ponnudurai, Maria C Petrone, Barbara Braden, Eike Burmester, Yi Dong, Nathan S Atkinson, Christoph F Dietrich
BACKGROUND:  The prevalence of malignancy in patients with small solid pancreatic lesions is low; however, early diagnosis is crucial for successful treatment of these cases. Therefore, a method to reliably distinguish between benign and malignant small solid pancreatic lesions would be highly desirable. We investigated the role of endoscopic ultrasound (EUS) elastography in this setting. METHODS:  Patients with solid pancreatic lesions ≤ 15 mm in size and a definite diagnosis were included...
April 24, 2018: Endoscopy
https://www.readbyqxmd.com/read/29662318/rare-malignant-insulinoma-with-multiple-liver-metastases-derived-from-ectopic-pancreas-3-year-follow-up-and-literature-review
#13
Qing Liu, Jianghui Duan, Yumin Zheng, Jie Luo, Xiaopin Cai, Huangying Tan
Here, we report the diagnosis and treatment of a very rare case of malignant insulinoma derived from ectopic pancreas. A middle-aged woman presented with a 6-year history of recurrent hypoglycemia with multiple lesions in liver. Admission workup revealed elevated serum insulin and C-peptide, as well as multiple lesions in the liver (largest being 4.3 cm), enlarged lymph nodes around the pancreas, and a lesion (of 3.5 cm) at the proximal jejunum, as shown by contrast computed tomography (CT). Liver biopsy showed the lesions to be well-differentiated neuroendocrine tumors, grade G1...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29629320/combined-associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-alpps-followed-by-left-trisectionectomy-and-whipple-operation-for-pnet
#14
Ren Ji, Shi Zuo, Siyuan Qiu, Ping Li, Albert Chan, William Sharr, Chung Mau Lo
Pancreatic neuroendocrine tumor (PNET) is slow-growing, and account only for 2% of all pancreatic primary tumors. Surgical resection is still the only curative treatment for PNET patients. Unfortunately, most of PNETs was found with unresectable multiple liver metastases and extrahepatic metastasis as their characteristics of non-functional and asymptomatic. With advances in liver surgery in these years, especially combined associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), provide a new curative surgical treatment for PNET with liver metastases patient...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29629319/liver-transplantation-for-unresectable-pancreatic-neuroendocrine-tumors-with-liver-metastases-in-an-era-of-transplant-oncology
#15
REVIEW
Keita Shimata, Yasuhiko Sugawara, Taizo Hibi
Patients with pancreatic neuroendocrine tumors (pNETs) very often present with a metastatic disease at the first diagnosis. Liver transplantation (LT) for unresectable pNET with liver metastases (pNETLM) has been described to prolong survival in highly selected patients, although outcomes were worse than those of patients who underwent LT for gastrointestinal NETLM (GI-NETLM). In this review, several proposed criteria are described with their rationale and controversies. Most of the data used to establish these criteria do not reflect the recent improvements of non-surgical treatments that has changed the landscape of treatment for pNETs, including the development of peptide receptor radionuclide therapy and molecular-targeted agents (sunitinib and everolimus)...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29629317/surgical-management-of-neuroendocrine-tumor-associated-liver-metastases-a-review
#16
REVIEW
Miu Yee Chan, Ka Wing Ma, Albert Chan
Liver metastasis is common among patients who suffer from neuroendocrine tumors (NETs). Radical surgery is the standard treatment whenever possible but there is still controversies concerning the treatment strategies such as resection of the primary, role of debulking surgery, liver transplantation (LT) and neoadjuvant or adjuvant therapies. This article aims to review the current evidence available, together with some latest updates, focusing on the surgical management.
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29629316/management-of-functional-neuroendocrine-tumors-of-the-pancreas
#17
REVIEW
Kjell Öberg
Pancreatic neuroendocrine tumors (pNETs) constitute a heterogenous group of malignancies with varying clinical presentation, tumor biology and prognosis. The incidence of pNETs has steadily increased during the last decades with an estimated incidence 2012 of 4.8/100,000. Recent whole genome sequencing of pNETs has demonstrated mutations in the DNA repair genes MUTYH and point mutations and gene fusions in four main pathways from chromatin remodeling, DNA damage repair, activation of mechanistic target of rapamycin (mTOR) signaling and the telomere maintenance...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29626307/preoperative-fluorouracil-doxorubicin-and-streptozocin-for-the-treatment-of-pancreatic-neuroendocrine-liver-metastases
#18
Jordan M Cloyd, Kiyohiko Omichi, Takashi Mizuno, Yoshikuni Kawaguchi, Ching-Wei D Tzeng, Claudius Conrad, Yun Shin Chun, Thomas A Aloia, Matthew H G Katz, Jeffrey E Lee, Daniel Halperin, James Yao, Jean-Nicolas Vauthey, Arvind Dasari
INTRODUCTION: While preoperative chemotherapy is frequently utilized before resection of non-neuroendocrine liver metastases, patients with resectable neuroendocrine liver metastases typically undergo surgery first. FAS is a cytotoxic chemotherapy regimen that is associated with substantial response rates in locally advanced and metastatic pancreatic neuroendocrine tumors. METHODS: All patients who underwent R0/R1 resection of pancreatic neuroendocrine liver metastases at a single institution between 1998 and 2015 were included...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29595759/multimodal-management-of-locally-advanced-neuroendocrine-cervical-carcinoma-a-single-institution-experience
#19
Pauline Castelnau-Marchand, Patricia Pautier, Catherine Genestie, Alexandra Leary, Enrica Bentivegna, Sébastien Gouy, Jean-Yves Scoazec, Philippe Morice, Christine Haie-Meder, Cyrus Chargari
OBJECTIVE: The aim of this study was to report our institutional experience of a multimodal approach for treatment of locally advanced high-grade neuroendocrine cervical cancer. METHODS AND MATERIALS: Patients with primary locally advanced neuroendocrine cervical cancer diagnosed between 2001 and 2014 were included. The scheduled treatment sequence was as follows: pelvic +/- para-aortic radiotherapy (according to tumor stage), associated with chemotherapy based on platine-derivate and etoposide regimen, followed with a brachytherapy boost, then completion surgery if there was no progression +/- consolidation etoposide chemotherapy (for a total of 5-6 cycles)...
March 27, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29556962/update-on-merkel-cell-carcinoma
#20
Michael T Tetzlaff, Priyadharsini Nagarajan
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. Incidence of MCC continues to rise, and risk factors include advanced age, pale skin, chronic sun exposure, and immune suppression. Diagnosing MCC utilizes a combination of morphology and immunohistochemistry. Merkel cell polyomavirus (MCPyV) is present in approximately 70-80% of MCCs and represents a key pathogenic driver in those MCCs. In contrast, MCPyV-negative MCCs arise through progressive accumulation of ultraviolet-light induced somatic mutations...
March 2018: Head and Neck Pathology
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