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Soichiro Kageyama, Takeki Ohashi, Akinori Kojima
Pulmonary tumor thrombotic microangiopathy (PTTM) is a very rare condition that can lead to acute severe pulmonary hypertension and circulatory failure. It is caused by tumor cell microvascular obstruction and is usually difficult to diagnose; in fact, it is often diagnosed after death. We report the case of a patient who experienced a sudden cardiac arrest and developed severe pulmonary hypertension two days after receiving the coronavirus disease (COVID-19) vaccine. The patient was initially diagnosed with vaccine-associated myocarditis, and venoarterial extracorporeal membrane oxygenation (VA-ECMO) implantation with median sternotomy was performed...
March 2024: Curēus
#2
JOURNAL ARTICLE
Lisa M Verheul, Sanne A Groeneveld, Job Stoks, Wiert F Hoeksema, Matthijs J M Cluitmans, Pieter G Postema, Arthur A M Wilde, Paul G A Volders, Rutger J Hassink
BACKGROUND: Idiopathic ventricular fibrillation (iVF) is a rare cause of sudden cardiac arrest and, by definition, a diagnosis of exclusion. Due to the rarity of the disease, previous and current studies are limited by their retrospective design and small patient numbers. Even though the incidence of iVF has declined owing to the identification of new disease entities, an important subgroup of patients remains. AIM: To expand the existing Dutch iVF Registry into a large nationwide cohort of patients initially diagnosed with iVF, to reveal the underlying cause of iVF in these patients, and to improve arrhythmia management...
April 23, 2024: Netherlands Heart Journal
#3
JOURNAL ARTICLE
Bernhard Scharinger, Elke Boxhammer, Richard Rezar, Stefan Hecht, Sarah Wernly, Tobias Widhalm, Michael Lichtenauer, Uta C Hoppe, Klaus Hergan, Bernhard Wernly, Bernhard Strohmer, Reinhard Kaufmann
Purpose To perform a systematic review to assess the diagnostic and prognostic value of cardiac MRI after sudden cardiac arrest (SCA). Materials and Methods PubMed and Cochrane Library databases were systematically searched for studies investigating cardiac MRI after SCA in adult patients (≥18 years of age). The time frame of the encompassed studies spans from January 2012 to January 2023. The study protocol was preregistered in OSF Registries (www.osf.io/nxaev) , and the systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
April 2024: Radiology. Cardiothoracic imaging
#4
JOURNAL ARTICLE
Joseph Burns, Ezinne Emeruwa, Patrick Connell, Nirica Borges, Dana Reaves-O'Neal, Silvana Molossi
Anomalous aortic origin of the left coronary artery (AAOLCA) confers high risk for sudden cardiac arrest (SCA). This series aims to describe consecutive admissions with interarterial AAOLCA presenting with SCA and distinct clinical trajectories. An eight-year-old boy collapsed at school and received 10-min of cardiopulmonary resuscitation (CPR) and defibrillation prior to return of spontaneous circulation. He had no end-organ dysfunction and underwent uneventful coronary unroofing. In contrast, a 14-year-old boy presented with collapse while jogging...
April 17, 2024: World Journal for Pediatric & Congenital Heart Surgery
#5
James Ainsworth, Adrian Ionescu
BACKGROUND: Mitral valve prolapse (MVP) is a common condition with an estimated prevalence of 1-3%, in which there is systolic displacement of a morphologically redundant mitral valve towards the left atrium. Mitral annular disjunction (MAD) is a separation of the MV attachment with the left ventricle, with hypermobility of the leaflets, and with systolic "curling" of the basal LV (left ventricle) myocardium. It is frequently associated with MVP and may confer an increased arrhythmic risk...
2024: Case Reports in Critical Care
#6
JOURNAL ARTICLE
Cátia Oliveira, Ana Pinho, Luís Santos, Ricardo Alves Pinto, Sílvia Oliveira, Helena Moreira, Miguel Rocha, Pedro Palma, Gonçalo Pestana, Marta Madeira, Ana Lebreiro, Luís Adão
INTRODUCTION AND OBJECTIVES: Idiopathic ventricular fibrillation (IVF) is diagnosed in patients who survive sudden cardiac arrest (SCA), preferably with documented ventricular fibrillation (VF), without any identifiable structural or electrical abnormality. Current evidence provides limited guidance on the diagnosis and follow-up of these patients. Our aim was to assess the clinical outcomes of survivors of an aborted SCA attributed to IVF. METHODS: We retrospectively collected clinical data from all patients who survived SCA and implanted a cardiac defibrillator (ICD) between 2005 and 2023...
April 12, 2024: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
#7
REVIEW
Zhangwei Wang, Kai Ma, Yaobin Zhu, Shoujun Li
Hypertrophic cardiomyopathy is the second most common cardiomyopathy affecting children and adolescents and is the main cause of sudden death of young athletes. The natural prognosis of children with severe hypertrophic obstructive cardiomyopathy is not optimistic, and it is not uncommon for children with hypertrophic obstructive cardiomyopathy who do not respond to medication. Surgical treatment is often the only solution. Conventional surgical methods in the past include classic or modified extended Morrow operation, classic or modified Konno operation, and Ross-Konno operation...
April 11, 2024: Cardiology in the Young
#8
JOURNAL ARTICLE
Janne T Rahola, Severi M Mattila, Antti M Kiviniemi, Olavi H Ukkola, Mikko P Tulppo, M Juhani Junttila, Heikki V Huikuri, Tuomas V Kenttä, Juha S Perkiömäki
BACKGROUND: Data on the prognostic significance of temporal variability of spatial heterogeneity of electrocardiographic repolarization in coronary artery disease (CAD) are limited. OBJECTIVE: The purpose of this study was to evaluate the prognostic value of temporal variability of T-wave morphology analyzed from a 5-minute resting electrocardiogram in CAD. METHODS: The standard deviation (SD) of T-wave morphology dispersion (TMD-SD) and the SD of total cosine R-to-T were analyzed on a beat-to-beat basis from a 5-minute period of the standard resting 12-lead electrocardiogram obtained before the clinical stress test in 1702 patients with angiographically verified CAD and well-preserved left ventricular function...
April 6, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#9
REVIEW
Jan van Amsterdam, Femke Gresnigt, Wim van den Brink
Background : The simultaneous use of cocaine and alcohol is highly prevalent and is associated with high numbers of emergency department admissions, primarily due to cardiovascular complications. Aims: To answer the question of whether the co-use of cocaine and alcohol increases the cardiovascular risk compared to the use of cocaine alone. Method : A systematic review of human studies comparing the cardiovascular risk of co-used cocaine and alcohol with the use of cocaine alone. Results : Despite a higher myocardial workload induced by the co-use of cocaine and alcohol and the potentiation of cocaine's cardiovascular effects by alcohol, the findings on the risk and severity of cardiovascular symptoms due to combined use are inconsistent...
March 4, 2024: Journal of Clinical Medicine
#10
JOURNAL ARTICLE
Avani Lamba, Thomas M Roston, Puck J Peltenburg, Dania Kallas, Sonia Franciosi, Krystien V V Lieve, Prince J Kannankeril, Minoru Horie, Seiko Ohno, Ramon Brugada, Takeshi Aiba, Peter Fischbach, Linda Knight, Jan Till, Sit-Yee Kwok, Vincent Probst, David Backhoff, Martin J LaPage, Anjan S Batra, Fabrizio Drago, Kristina Haugaa, Andrew D Krahn, Tomas Robyns, Heikki Swan, Terezia Tavacova, Joseph Atallah, Martin Borggrefe, Boris Rudic, Georgia Sarquella-Brugada, Ehud Chorin, Allison Hill, Janneke Kammeraad, Anna Kamp, Ian Law, James Perry, Jason D Roberts, Svjetlana Tisma-Dupanovic, Christopher Semsarian, Jonathan R Skinner, Jacob Tfelt-Hansen, Isabelle Denjoy, Antoine Leenhardt, Peter J Schwartz, Michael J Ackerman, Arthur A M Wilde, Christian van der Werf, Shubhayan Sanatani
BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) may cause sudden cardiac death (SCD) despite medical therapy. Therefore, implantable cardioverter defibrillators (ICDs) are commonly advised. However, there are limited data on the outcomes of ICD use in children. OBJECTIVE: To compare the risk of arrhythmic events in pediatric CPVT patients with and without ICDs. METHODS: We compared the risk of SCD in RYR2 variant and phenotype positive symptomatic CPVT patients with and without ICDs, who were <19 years of age and had no history of sudden cardiac arrest (SCA) at phenotype diagnosis...
April 6, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#11
JOURNAL ARTICLE
Aman Goyal, Mohammed A Quazi, Rayika Syed, Hafiz Abdullah Ikram, Farooq A Sheikh, Asif Farooq, Sulaiman Sultan, Abu Baker Sheikh
Introduction Existing data suggest an association between primary spontaneous pneumothorax (PSP) and cannabis consumption, although evidence remains controversial. Methods This study used the 2016-2019 National Inpatient Sample Database to examine inpatients with PSP, categorizing them as cannabis users and non-users. Multivariate regression analyzed continuous variables, chi-square assessed categorical variables, and logistic regression models were built. Propensity score matching (PSM) mitigated the confounding bias...
March 2024: Curēus
#12
Santiago Luna-Alcala, Mauricio Garcia-Cardenas, Enrique C Guerra, Pavel Martinez-Dominguez, Aldo Cabello-Ganem, Leonardo Proaño-Bernal, Cristian A Chava-Ponte, Arturo Hernandez-Pacherres, Nilda Espinola-Zavaleta
Arrhythmogenic cardiomyopathy is a biventricular disease in which the effect on the left ventricle can be either equivalent to or more severe than that on the right ventricle. It is a rare disease due to its low reported prevalence and typically becomes clinically evident during the second to fourth decade of life. It represents 4% of sudden cardiac death cases referred for autopsy and 10% of cases of unexplained cardiac arrest. We present a challenging case report of a 68-year-old man who arrived at the emergency room with chest discomfort, palpitations, and light-headedness before a syncopal episode with urinary incontinence...
June 2024: Radiology Case Reports
#13
JOURNAL ARTICLE
Razan Dankar, Jad Wehbi, Mohamad Montaser Atasi, Samir Alam, Marwan M Refaat
The coronary vascular system has a unique structure and function that is adaptive to myocardial demand. It is composed of a continuous network of vessels receding in size from epicardial arteries to the microvascular circulation. Failure to meet myocardial demand results in ischemia, angina, and adverse myocardial outcomes. It is evident that 50 % of patients with angina have a non-obstructive coronary disease and 66 % of these patients have coronary microvascular dysfunction (CMD). The impact of CMD on the atria and ventricles is exhibited through its association with atrial fibrillation and distortion of ventricular repolarization...
May 2024: American heart journal plus: cardiology research and practice
#14
JOURNAL ARTICLE
Marie Renaudier, Yannick Binois, Florence Dumas, Lionel Lamhaut, Frankie Beganton, Daniel Jost, Julien Charpentier, Olivier Lesieur, Eloi Marijon, Xavier Jouven, Alain Cariou, Wulfran Bougouin
BACKGROUND: Controlled donation after circulatory death (cDCD) in post-anoxic brain injury is a valuable source of organs that is still underused in some countries. We assessed the number of potential cDCD donors after out-of-hospital cardiac arrest (OHCA) in Paris and its suburbs and extrapolated the results to the French population. METHODS: Using the large regional registry of the Great Paris area, we prospectively included all consecutive adults with OHCA with a stable return of spontaneous circulation (ROSC) who ultimately died in the intensive care unit (ICU) after withdrawal of life-sustaining treatments (WLST) due to post anoxic brain injury...
April 4, 2024: Resuscitation
#15
JOURNAL ARTICLE
Niels Kjær Stampe, Charlotte Glinge, Brian Schou Rasmussen, Priya Bhardwaj, Kristian Linnet, Reza Jabbari, Christian Paludan-Müller, Christian Hassager, Jesper Kjærgaard, Jacob Tfelt-Hansen, Bo Gregers Winkel
BACKGROUND: There has been no previous thorough toxicological examination of a cohort of patients with resuscitated sudden cardiac arrest. We aimed to determine the qualitative and quantitative drug composition in a resuscitated sudden cardiac arrest population, using forensic toxicology, with focus on prescribed, non-prescribed, and commonly abused drugs. METHODS: Individuals aged 18-90 years with resuscitated sudden cardiac arrest of presumed cardiac causes were prospectively included from a single-tertiary-center...
April 4, 2024: Resuscitation
#16
JOURNAL ARTICLE
Cristina Gómez González, Iván Del Campo Cano, Ana Isabel Fernández-Avila, Maria Paz Suárez-Mier, María José Sagastizábal, Reyes Álvarez García-Rovés, Irene Méndez Fernández, Silvia Vilches, Miriam Centeno Jiménez, Ana Siles Sánchez-Manjavacas, Ana Usano Carrasco, Emiliano Gonzalez-Vioque, Juan Pablo Ochoa, Constancio Medrano, Esther González López, Pablo García-Pavía, Javier Bermejo, María Angeles Espinosa Castro
Biallelic variants in PPA2 gene cause a rare but lethal mitochondrial disorder. We describe the first four cases reported in Spain of PPA2 disease in two unrelated families. We have conducted a revision of the clinical history, necropsies, and postmortem genetic testing from probands, and clinical evaluation, genetic testing and blood transcript analysis in family members. All the cases harbored biallelic PPA2 variants in compound heterozygous status. Two brothers from family 1 suffered sudden death after a small first intake of alcohol in 2013 and 2022...
April 4, 2024: Gene
#17
REVIEW
Tina Nham, Michael Cristian Garcia, Kai La Jennifer Tsang, Jessyca Matos Silva, Tyler Schneider, Jiawen Deng, Simran Lohit, Lawrence Mbuagbaw, Anne Holbrook
BACKGROUND: Cholinesterase inhibitors (ChEIs) are regularly used in Alzheimer's disease. Of the three ChEIs approved for dementia, donepezil is among the most prescribed drugs in the United States with nearly 6 million prescriptions in 2020; however, it is classified as a "known risk" QT interval-prolonging medication (QTPmed). Given this claim is derived from observational data including single case reports, we aimed to evaluate high-quality literature on the frequency and nature of proarrhythmic major adverse cardiac events (MACE) associated with donepezil...
April 5, 2024: Journal of the American Geriatrics Society
#18
JOURNAL ARTICLE
Hui Sun, Xin Liu, Jin Fu, Yin Song, Xiaoxiao Qin, Haiyin Wang
OBJECTIVES: Implantable cardioverter defibrillator (ICDs) for primary prevention (PP) of sudden cardiac arrest (SCA) is underutilized in developing countries. The Improve SCA study has identified a subset of 1.5 primary prevention (1.5PP) patients with a higher risk of SCA and a significant mortality benefit from ICD therapy. From the perspective of China's healthcare system, we evaluated the cost-effectiveness of ICD therapy vs. no ICD therapy among1.5PP patients with a view of informing clinical and policy decisions...
April 3, 2024: Journal of Medical Economics
#19
JOURNAL ARTICLE
Chandan Kumar Jha
Abnormal cardiac functionality produces irregular heart rhythms which are commonly known as arrhythmias. In some conditions, arrhythmias are treated as very dangerous which may lead to sudden cardiac arrest. The incidence and prevalence of cardiac anomalies seeks early detection of arrhythmias using automated classification techniques. In the past, numerous automated arrhythmia detection techniques have been developed that are based on electrocardiogram (ECG) signal analysis. Focusing on the prospective research in this field, this article reports a comprehensive review of existing techniques that are obtained using search engines such as IEEE explore, Google scholar and science direct...
April 2, 2024: Computer Methods in Biomechanics and Biomedical Engineering
#20
JOURNAL ARTICLE
Markus Hautamäki, Minna Järvensivu-Koivunen, Leo-Pekka Lyytikäinen, Markku Eskola, Terho Lehtimäki, Kjell Nikus, Niku Oksala, Juho Tynkkynen, Jussi Hernesniemi
Background. Sudden cardiac arrest (SCA), often also leading to sudden cardiac death (SCD), is a common complication in coronary artery disease. Despite the effort there is a lack of applicable prediction tools to identify those at high risk. We tested the association between the validated GRACE score and the incidence of SCA after myocardial infarction. Material and methods. A retrospective analysis of 1,985 patients treated for myocardial infarction (MI) between January 1st 2015 and December 31st 2018 and followed until the 31st of December of 2021...
December 2024: Scandinavian Cardiovascular Journal: SCJ
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