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Nina Attridge, Christopher Eccleston, Donna Noonan, Elaine Wainwright, Edmund Keogh
: Pain is thought to capture our attention. A consequence is that our performance on other tasks may suffer. Research has supported this, showing that pain disrupts our ability to perform various attention tasks. However, the specific nature of the effect of pain on attention is inconsistent, possibly due to different studies investigating different types of pain. Few studies seek to replicate basic findings. Here, we conceptually replicated and extended the headache study by Moore, Keogh & Eccleston (2013), by including two additional attention tasks, a broader sample, and measures of affect and pain cognitions...
October 11, 2016: Journal of Pain: Official Journal of the American Pain Society
Ashok Kumar Saxena, Geetanjali T Chilkoti, Anand K Chopra, Basu Dev Banerjee, Tusha Sharma
BACKGROUND: The present study was undertaken to evaluate the incidence of chronic persistent post-surgical pain (CPPP) and the role of signal transduction genes in patients undergoing staging laparotomy for carcinoma ovary. METHODS: The present observational study was undertaken following institutional ethical committee approval and informed consent from all the participants. A total 21 patients of ASA grade I to III with age 20-70 years, scheduled for elective staging laparotomy for carcinoma ovary were included...
October 2016: Korean Journal of Pain
Ludovic Giloteaux, Maureen R Hanson, Betsy A Keller
BACKGROUND Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) present with profound fatigue, flu-like symptoms, pain, cognitive impairment, orthostatic intolerance, and post-exertional malaise (PEM), and exacerbation of some or all of the baseline symptoms. CASE REPORT We report on a pair of 34-year-old monozygotic twins discordant for ME/CFS, with WELL, the non-affected twin, and ILL, the affected twin. Both twins performed a two-day cardiopulmonary exercise test (CPET), pre- and post-exercise blood samples were drawn, and both provided stool samples for biochemical and molecular analysis...
October 10, 2016: American Journal of Case Reports
Juliana Maria de Freitas Trindade Costa, Aline Ranzolin, Cláudio Antônio da Costa Neto, Claudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte
: Fibromyalgia (FM) and hyperparathyroidism may present similar symptoms (musculoskeletal pain, cognitive disorders, insomnia, depression and anxiety), causing diagnostic confusion. OBJECTIVES: To determine the frequency of asymptomatic hyperparathyroidism in a sample of patients with FM and to evaluate the association of laboratory abnormalities to clinical symptoms. METHODS: Cross-sectional study with 100 women with FM and 57 healthy women (comparison group)...
September 2016: Revista Brasileira de Reumatologia
Nora E Fritz, Snehashis Roy, Jennifer Keller, Jerry Prince, Peter A Calabresi, Kathleen M Zackowski
BACKGROUND: Multiple sclerosis (MS) is characterized by physical and mental impairments that often result in pain and reduced quality of life. OBJECTIVE: To understand the relationship of pain, quality of life, and cognition to structural measures of brain volume. METHODS: Behavioral measures were assessed in a single session using standardized questionnaires and rating scales. Brain volume measures were assessed with structural magnetic resonance imaging (MRI)...
September 27, 2016: NeuroRehabilitation
Cherriere Claire, Melissa Martel, Sylvie Fortin, Marie-Joanie Raymond, Louis Nicolas Veilleux, Sylvie D'Arcy, Martin Lemay
OBJECTIVE: Charcot-Marie-Tooth disease (CMT) is a hereditary peripheral neuropathy and belongs to neuromuscular diseases. CMT affects motor function of children, but its clinical expressions are heterogeneous and it could also influence cognitive and psychosocial dimensions of patients. Physical activity is recommended for adults with CMT, but any study has been conducted with children. It is important to propose to children with CMT an adapted physical activity that enables a global approach of the patient...
September 2016: Annals of Physical and Rehabilitation Medicine
Sauro Salomoni, Kylie Tucker, François Hug, Megan McPhee, Paul Hodges
Although maximal voluntary contraction (MVC) force is reduced during pain, studies using interpolated twitch show no consistent reduction of voluntary muscle drive. The present study aimed to test if the reduction in MVC force during acute experimental pain could be explained by increased activation of antagonist muscles, weak voluntary activation at baseline, or changes in force direction. Twenty-two healthy volunteers performed maximal voluntary isometric knee extensions before, during, and after the effects of hypertonic (pain) and isotonic (control) saline injections into the infrapatellar fat pad...
2016: PloS One
Saba Shahab, Diana-Felicia Nicolici, Alva Tang, Paul Katz, Linda Mah
OBJECTIVE: To evaluate the effect of depression on functional recovery in geriatric patients who have completed an inpatient rehabilitation program. DESIGN: Prospective cohort study. SETTING: Inpatient rehabilitation unit of a university-affiliated geriatric hospital. PARTICIPANTS: Convenience sample of patients (N=65; mean age, 81.6y; 25 men) admitted to rehabilitation over a 10-month period. Patients >60 years of age who were proficient in English and capable of providing informed consent were eligible to participate in the study...
August 13, 2016: Archives of Physical Medicine and Rehabilitation
Nicholas Fallon, Yee Chiu, Turo Nurmikko, Andrej Stancak
Fibromyalgia syndrome (FMS) patients show altered connectivity with the network maintaining ongoing resting brain activity, known as the default mode network (DMN). The connectivity patterns of DMN with the rest of the brain in FMS patients are poorly understood. This study employed seed-based functional connectivity analysis to investigate resting-state functional connectivity with DMN structures in FMS. Sixteen female FMS patients and 15 age-matched, healthy control subjects underwent T2-weighted resting-state MRI scanning and functional connectivity analyses using DMN network seed regions...
2016: PloS One
Michael S Putman, Hyo Jung Tak, Farr A Curlin, John D Yoon
OBJECTIVES: Physician recommendations for further medical treatment or palliative treatment only at the end of life may influence patient decisions. Little is known about the patient characteristics that affect physician-assessed quality of life or how such assessments are related to subsequent recommendations. DESIGN, SETTING, AND SUBJECTS: A 2010 mailed survey of practicing U.S. physicians (1,156/1,878 or 62% of eligible physicians responded). MEASUREMENTS AND MAIN RESULTS: Measures included an end of life vignette with five experimentally varied patient characteristics: setting, alimentation, pain, cognition, and communication...
November 2016: Critical Care Medicine
Florian S Eichler, Timothy M Cox, Eric Crombez, Christine Í Dali, Alfried Kohlschütter
Metachromatic leukodystrophy is accompanied by severe motor and cognitive dysfunction. This is the first survey of metachromatic leukodystrophy caregiver perspectives to identify relevant clinical/quality-of-life outcomes for patients/caregivers. Interviews and 1 focus group were conducted with 30 caregivers representing 23 patients. Caregivers were asked about their experiences, including diagnostic process, signs/symptoms, symptoms affecting caregivers' and patients' lives, and treatment priorities. Caregivers reported loss of physical autonomy, weight loss, limited social relationships, frequent crying, and challenging sibling relationships...
July 7, 2016: Journal of Child Neurology
M Nørgaard, J J Lomholt, M Thastum, M Herlin, M Twilt, T Herlin
OBJECTIVES: Pain has been known to predict low physical activity (PA) in juvenile idiopathic arthritis (JIA) and high levels of pain are related to maladaptive coping rather than disease severity. Objectively monitored PA in JIA has recently been shown not to be related to pain intensity, emphasizing the need to explore pain more deeply. The aim of this study was to examine accelerometer-assessed PA in relation to pain cognition in children with JIA. METHOD: Data gathered included disease activity, functional ability, and pain cognition...
June 16, 2016: Scandinavian Journal of Rheumatology
Hannah M O'Rourke, Kimberly D Fraser, Wendy Duggleby, Norah Keating
OBJECTIVES: Research into the lived experiences of long-term care residents with dementia has identified perceived conflict, and its impact on sadness, as priorities for quality of life from the perspectives of people with dementia. However, whether and to what extent perceived conflict and sadness are associated has not been previously tested in this population. This study tested the associations between perceived conflicts with staff, family or friends and co-residents and their experience of sadness, and whether cognitive impairment or functional dependence modified these associations...
June 15, 2016: Dementia
Juliana Maria de Freitas Trindade Costa, Aline Ranzolin, Cláudio Antônio da Costa Neto, Claudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte
: Fibromyalgia (FM) and hyperparathyroidism may present similar symptoms (musculoskeletal pain, cognitive disorders, insomnia, depression and anxiety), causing diagnostic confusion. OBJECTIVES: To determine the frequency of asymptomatic hyperparathyroidism in a sample of patients with FM and to evaluate the association of laboratory abnormalities to clinical symptoms. METHODS: Cross-sectional study with 100 women with FM and 57 healthy women (control group)...
March 22, 2016: Revista Brasileira de Reumatologia
Qian Zheng, Li-hua Zhang, Li Huang, Guang-ping Wang, Xiao-ping Yuan, Xiao-mei Xu
PURPOSE: To investigate the effects of different psychological interventions on relieving orthodontic pain in patients with different personalities. METHODS: Three hundred patients were involved and randomized into five groups:control group, cognitive therapy group, music therapy group, muscle relaxation group and suggestion therapy group. Eysenck personality questionnaire was used to evaluate personality traits of patients, and visual analogue scale (VAS) was used to assess patients' intensity of orthodontic pain at 2, 6, 12, 24, 48 and 72 h after initial archwire placement...
February 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Donna-Ann Thomas, Benjamin Maslin, Aron Legler, Erin Springer, Abbas Asgerally, Nalini Vadivelu
There is increasing interest in the use of complimentary and alternative medicine (CAM) for the treatment of chronic pain. This review examines alternative and complimentary therapies, which can be incorporated as part of a biopsychosocial approach in the treatment of chronic pain syndromes. In the present investigation, literature from articles indexed on PubMed was evaluated including topics of alternative therapies, complimentary therapies, pain psychology, biofeedback therapy, physical exercise therapies, acupuncture, natural and herbal supplements, whole-body cryotherapy, and smartphone technologies in the treatment of chronic pain syndromes...
May 2016: Current Pain and Headache Reports
Tareef Al-Aama
To assess the basic knowledge of medical trainees, in the absence of a structured geriatrics curriculum, around a variety of geriatric medicine components that are considered essential for the care of the rapidly increasing elderly population. Eighty-three trainees at different levels of training in internal medicine were asked about a variety of common geriatric conditions. Those included: delirium, falls, geriatric syndromes, pain, cognitive impairment, and medications. The trainees' knowledge about common geriatric condition was overall poor...
June 2016: Journal of Cross-cultural Gerontology
Jesper T Andreasen, Arafat Nasser, Maitane Caballero-Puntiverio, Maj Sahlholt, Anders Bach, Mikko Gynther, Kristian Strømgaard, Darryl S Pickering
NMDAR antagonism shows analgesic action in humans and animal pain models, but disrupts cognitive and motor functions. NMDAR-dependent NO production requires tethering of the NMDAR to neuronal NO synthase (nNOS) by the postsynaptic density protein-95 (PSD-95). Perturbing the NMDAR/PSD-95/nNOS interaction has therefore been proposed as an alternative analgesic mechanism. We recently reported that UCCB01-125, a dimeric PSD-95 inhibitor with limited blood-brain-barrier permeability, reduced mechanical hypersensitivity in the complete Freund's adjuvant (CFA) inflammatory pain model, without disrupting cognitive or motor functions...
June 5, 2016: European Journal of Pharmacology
William Lu, Jason W Krellman, Marcel P Dijkers
BACKGROUND: Individuals with traumatic brain injury (TBI) often develop sleep disorders post-injury. The most common one is insomnia, which can exacerbate other post-injury symptoms, including fatigue, impaired cognition, depression, anxiety, and pain. Cognitive Behavioral Therapy for Insomnia (CBT-I) is a manualized treatment that effectively treats insomnia with secondary effects on cognition, mood, and pain in various populations. OBJECTIVE: This paper reviews the use of CBT-I for three participants with TBI of different severities...
2016: NeuroRehabilitation
Alexandra B Anderson, Natalie O Rosen, Lisa Price, Sophie Bergeron
INTRODUCTION: Provoked vestibulodynia (PVD) is a common vulvovaginal pain condition that negatively impacts women's psychological and sexual well-being. Controlled studies have found that women with PVD report greater negative and less positive cognitions about penetration; however, associations between these types of cognitions and women's pain and sexual well-being remain unknown. Further, researchers have yet to examine how interpersonal variables such as sexual communication may impact the association between women's penetration cognitions and PVD outcomes...
March 2016: Journal of Sexual Medicine
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