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Melatonin prostatic cancer

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https://www.readbyqxmd.com/read/27876126/regular-sun-exposure-benefits-health
#1
H J van der Rhee, E de Vries, J W Coebergh
Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between sunlight and disease have been discovered. There is growing observational and experimental evidence that regular exposure to sunlight contributes to the prevention of colon-, breast-, prostate cancer, non-Hodgkin lymphoma, multiple sclerosis, hypertension and diabetes...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27736013/igfbp3-and-mapk-erk-signaling-mediates-melatonin-induced-antitumor-activity-in-prostate-cancer
#2
Juan C Mayo, David Hevia, Isabel Quiros-Gonzalez, Aida Rodriguez-Garcia, Pedro Gonzalez-Menendez, Vanesa Cepas, Iván Gonzalez-Pola, Rosa M Sainz
Treatment of prostate cancer (PCa), a leading cause of cancer among males, lacks successful strategies especially in advanced, hormone-refractory stages. Some clinical studies have shown an increase in neuroendocrine-like cells parallel to the tumor progression but their exact role is a matter of debate. The prostate is a well-known target for melatonin, which reduces PCa cells proliferation and induces neuroendocrine differentiation. To evaluate the mechanisms underlying the indole effects on neuroendocrine differentiation and its impact on PCa progression, we used a cell culture model (LNCaP) and a murine model (TRAMP)...
October 13, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27660402/circadian-rhythmicity-and-the-influence-of-clock-genes-on-prostate-cancer
#3
Zsofia Kiss, Paramita M Ghosh
The androgen receptor (AR) plays a key role in the development and progression of prostate cancer (CaP). Since the mid-1990s, reports in the literature pointed out higher incidences of CaP in some select groups, such as airline pilots and night shift workers in comparison to those working regular hours. The common finding in these 'high-risk' groups was that they all experienced a deregulation of the body's internal circadian rhythm. Here we discuss how the circadian rhythm affects androgen levels and modulates CaP development and progression...
September 22, 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27387675/urinary-melatonin-sulfate-cortisol-ratio-and-the-presence-of-prostate-cancer-a-case-control-study
#4
Shu-Yu Tai, Shu-Pin Huang, Bo-Ying Bao, Ming-Tsang Wu
The circadian-related hormones, melatonin and cortisol, have oncostatic and immunosuppressive properties. This study examined the relationship between these two biomarkers and the presence of prostate cancer. We measured their major metabolites in urine collected from 120 newly diagnosed prostate cancer patients and 240 age-matched controls from January 2011 to April 2014. Compared with patients with lower urinary melatonin-sulfate or melatonin-sulfate/cortisol (MT/C) ratio levels, those with above-median levels were significantly less likely to have prostate cancer (adjusted OR (aOR) = 0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26678364/daytime-blue-light-enhances-the-nighttime-circadian-melatonin-inhibition-of-human-prostate-cancer-growth
#5
Robert T Dauchy, Aaron E Hoffman, Melissa A Wren-Dail, John P Hanifin, Benjamin Warfield, George C Brainard, Shulin Xiang, Lin Yuan, Steven M Hill, Victoria P Belancio, Erin M Dauchy, Kara Smith, David E Blask
Light controls pineal melatonin production and temporally coordinates circadian rhythms of metabolism and physiology in normal and neoplastic tissues. We previously showed that peak circulating nocturnal melatonin levels were 7-fold higher after daytime spectral transmittance of white light through blue-tinted (compared with clear) rodent cages. Here, we tested the hypothesis that daytime blue-light amplification of nocturnal melatonin enhances the inhibition of metabolism, signaling activity, and growth of prostate cancer xenografts...
December 2015: Comparative Medicine
https://www.readbyqxmd.com/read/26374931/nocturnal-light-pollution-and-underexposure-to-daytime-sunlight-complementary-mechanisms-of-circadian-disruption-and-related-diseases
#6
EDITORIAL
Michael H Smolensky, Linda L Sackett-Lundeen, Francesco Portaluppi
Routine exposure to artificial light at night (ALAN) in work, home, and community settings is linked with increased risk of breast and prostate cancer (BC, PC) in normally sighted women and men, the hypothesized biological rhythm mechanisms being frequent nocturnal melatonin synthesis suppression, circadian time structure (CTS) desynchronization, and sleep/wake cycle disruption with sleep deprivation. ALAN-induced perturbation of the CTS melatonin synchronizer signal is communicated maternally at the very onset of life and after birth via breast or artificial formula feedings...
2015: Chronobiology International
https://www.readbyqxmd.com/read/26305219/residential-exposure-to-road-and-railway-noise-and-risk-of-prostate-cancer-a-prospective-cohort-study
#7
Nina Roswall, Kirsten T Eriksen, Dorrit Hjortebjerg, Steen S Jensen, Kim Overvad, Anne Tjønneland, Ole Raaschou-Nielsen, Mette Sørensen
BACKGROUND: Few modifiable risk factors for prostate cancer are known. Recently, disruption of the circadian system has been proposed to affect risk, as it entails an inhibited melatonin production, and melatonin has demonstrated beneficial effects on cancer inhibition. This suggests a potential role of traffic noise in prostate cancer. METHODS: Road traffic and railway noise was calculated for all present and historical addresses from 1987-2010 for a cohort of 24,473 middle-aged, Danish men...
2015: PloS One
https://www.readbyqxmd.com/read/26295055/influence-of-melatonin-on-the-proliferative-and-apoptotic-responses-of-the-prostate-under-normal-and-hyperglycemic-conditions
#8
Marina G Gobbo, Nishtman Dizeyi, Per-Anders Abrahamsson, Per-Anders Bertilsson, Viviane Sanches Masitéli, Eloisa Zanin Pytlowanciv, Sebastião R Taboga, Rejane M Góes
The antitumor properties of melatonin (MLT) are known for prostate cancer cells. This study investigated whether MLT affects prostate maturation and interferes with tissue injuries induced by diabetes. MLT was administered to Wistar rats from 5 weeks of age in the drinking water (10 μg/kg b.w.), and diabetes was induced at the 13th week by streptozotocin (4.5 mg/100g b.w., i.p.). The animals were euthanized in the 14th and 21st weeks. MLT reduced the immunostained cells for androgen receptor (AR) by 10% in younger rats...
2015: Journal of Diabetes Research
https://www.readbyqxmd.com/read/25780233/electric-light-particularly-at-night-disrupts-human-circadian-rhythmicity-is-that-a-problem
#9
REVIEW
Richard G Stevens, Yong Zhu
Over the past 3 billion years, an endogenous circadian rhythmicity has developed in almost all life forms in which daily oscillations in physiology occur. This allows for anticipation of sunrise and sunset. This physiological rhythmicity is kept at precisely 24 h by the daily cycle of sunlight and dark. However, since the introduction of electric lighting, there has been inadequate light during the day inside buildings for a robust resetting of the human endogenous circadian rhythmicity, and too much light at night for a true dark to be detected; this results in circadian disruption and alters sleep/wake cycle, core body temperature, hormone regulation and release, and patterns of gene expression throughout the body...
May 5, 2015: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/25737330/increased-and-mistimed-sex-hormone-production-in-night-shift-workers
#10
Kyriaki Papantoniou, Oscar J Pozo, Ana Espinosa, Josep Marcos, Gemma Castaño-Vinyals, Xavier Basagaña, Elena Juanola Pagès, Joan Mirabent, Jordi Martín, Patricia Such Faro, Amparo Gascó Aparici, Benita Middleton, Debra J Skene, Manolis Kogevinas
BACKGROUND: Night shift work has been associated with an increased risk for breast and prostate cancer. The effect of circadian disruption on sex steroid production is a possible underlying mechanism, underinvestigated in humans. We have assessed daily rhythms of sex hormones and melatonin in night and day shift workers of both sexes. METHODS: We recruited 75 night and 42 day workers, ages 22 to 64 years, in different working settings. Participants collected urine samples from all voids over 24 hours on a working day...
May 2015: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/25612238/melatonin-uptake-through-glucose-transporters-a-new-target-for-melatonin-inhibition-of-cancer
#11
David Hevia, Pedro González-Menéndez, Isabel Quiros-González, Ana Miar, Aida Rodríguez-García, Dun-Xian Tan, Russel J Reiter, Juan C Mayo, Rosa M Sainz
Melatonin is present in a multitude of taxa and it has a broad range of biological functions, from synchronizing circadian rhythms to detoxifying free radicals. Some functions of melatonin are mediated by its membrane receptors but others are receptor-independent. For the latter, melatonin must enter into the cell. Melatonin is a derivative of the amino acid tryptophan and reportedly easily crosses biological membranes due to its amphipathic nature. However, the mechanism by which melatonin enters into cells remains unknown...
March 2015: Journal of Pineal Research
https://www.readbyqxmd.com/read/25584113/molecularly-imprinted-electrochemical-sensing-of-urinary-melatonin-in-a-microfluidic-system
#12
Mei-Hwa Lee, Danny O'Hare, Yi-Li Chen, Yu-Chia Chang, Chien-Hsin Yang, Bin-Da Liu, Hung-Yin Lin
Melatonin levels may be related to the risks of breast cancer and prostate cancer. The measurement of urinary melatonin is also useful in monitoring serum melatonin levels following oral administration. In this work, melatonin is the target molecule, which is imprinted onto poly(ethylene-co-vinyl alcohol) by evaporation of the solvent on the working electrode of an electrochemical sensing chip. This sensing chip is used directly as a tool for optimizing the imprinting polymer composition, flow rate, and injection volume of the samples...
September 2014: Biomicrofluidics
https://www.readbyqxmd.com/read/25553085/upregulation-of-mirna3195-and-mirna374b-mediates-the-anti-angiogenic-properties-of-melatonin-in-hypoxic-pc-3-prostate-cancer-cells
#13
Eun Jung Sohn, Gunho Won, Jihyun Lee, Sangyoon Lee, Sung-Hoon Kim
Recently microRNAs (miRNAs) have been attractive targets with their key roles in biological regulation through post-transcription to control mRNA stability and protein translation. Though melatonin was known as an anti-angiogenic agent, the underlying mechanism of melatonin in PC-3 prostate cancer cells under hypoxia still remains unclear. Thus, in the current study, we elucidated the important roles of miRNAs in melatonin-induced anti-angiogenic activity in hypoxic PC-3 cells. miRNA array revealed that 33 miRNAs (>2 folds) including miRNA3195 and miRNA 374b were significantly upregulated and 16 miRNAs were downregulated in melatonin-treated PC-3 cells under hypoxia compared to untreated control...
2015: Journal of Cancer
https://www.readbyqxmd.com/read/25282366/melatonin-sleep-and-prostate-cancer-in-elderly-men-study-hypothesis-development-and-icelandic-options
#14
EDITORIAL
Thomas C Erren, Tracy E Slanger, J Valérie Groß, Russel J Reiter
No abstract text is available yet for this article.
February 2015: European Urology
https://www.readbyqxmd.com/read/25107635/urinary-melatonin-levels-sleep-disruption-and-risk-of-prostate-cancer-in-elderly-men
#15
Lara G Sigurdardottir, Sarah C Markt, Jennifer R Rider, Sebastien Haneuse, Katja Fall, Eva S Schernhammer, Rulla M Tamimi, Erin Flynn-Evans, Julie L Batista, Lenore Launer, Tamara Harris, Thor Aspelund, Meir J Stampfer, Vilmundur Gudnason, Charles A Czeisler, Steven W Lockley, Unnur A Valdimarsdottir, Lorelei A Mucci
UNLABELLED: Melatonin has anticarcinogenic properties in experimental models. We undertook a case-cohort study of 928 Icelandic men without prostate cancer (PCa) nested within the Age, Gene/Environment Susceptibility (AGES)-Reykjavik cohort to investigate the prospective association between first morning-void urinary 6-sulfatoxymelatonin (aMT6s) levels and the subsequent risk for PCa, under the hypothesis that men with lower aMT6s levels have an increased risk for advanced PCa. We used weighted Cox proportional hazards models to assess the association between first morning-void aMT6s levels and PCa risk, adjusting for potential confounders...
February 2015: European Urology
https://www.readbyqxmd.com/read/24914052/regulation-of-l1-expression-and-retrotransposition-by-melatonin-and-its-receptor-implications-for-cancer-risk-associated-with-light-exposure-at-night
#16
Dawn deHaro, Kristine J Kines, Mark Sokolowski, Robert T Dauchy, Vincent A Streva, Steven M Hill, John P Hanifin, George C Brainard, David E Blask, Victoria P Belancio
Expression of long interspersed element-1 (L1) is upregulated in many human malignancies. L1 can introduce genomic instability via insertional mutagenesis and DNA double-strand breaks, both of which may promote cancer. Light exposure at night, a recently recognized carcinogen, is associated with an increased risk of cancer in shift workers. We report that melatonin receptor 1 inhibits mobilization of L1 in cultured cells through downregulation of L1 mRNA and ORF1 protein. The addition of melatonin receptor antagonists abolishes the MT1 effect on retrotransposition in a dose-dependent manner...
July 2014: Nucleic Acids Research
https://www.readbyqxmd.com/read/24867960/beyond-androgen-deprivation-ancillary-integrative-strategies-for-targeting-the-androgen-receptor-addiction-of-prostate-cancer
#17
Mark F McCarty, Jalal Hejazi, Reza Rastmanesh
The large majority of clinical prostate cancers remain dependent on androgen receptor (AR) activity for proliferation even as they lose their responsiveness to androgen deprivation or antagonism. AR activity can be maintained in these circumstances by increased AR synthesis--often reflecting increased NF-κB activation; upregulation of signaling pathways that promote AR activity in the absence of androgens; and by emergence of AR mutations or splice variants lacking the ligand-binding domain, which render the AR constitutively active...
September 2014: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/24786921/antitumour-activity-of-melatonin-in-a-mouse-model-of-human-prostate-cancer-relationship-with-hypoxia-signalling
#18
Rita Paroni, Laura Terraneo, Francesca Bonomini, Elena Finati, Eleonora Virgili, Paola Bianciardi, Gaia Favero, Franco Fraschini, Russel J Reiter, Rita Rezzani, Michele Samaja
Melatonin is known to exert antitumour activity in several types of human cancers, but the underlying mechanisms as well as the efficacy of different doses of melatonin are not well defined. Here, we test the hypothesis whether melatonin in the nanomolar range is effective in exerting antitumour activity in vivo and examine the correlation with the hypoxia signalling mechanism, which may be a major molecular mechanism by which melatonin antagonizes cancer. To test this hypothesis, LNCaP human prostate cancer cells were xenografted into seven-wk-old Foxn1nu/nu male mice that were treated with melatonin (18 i...
August 2014: Journal of Pineal Research
https://www.readbyqxmd.com/read/24378460/the-di-bella-method-dbm-in-the-treatment-of-prostate-cancer-a-preliminary-retrospective-study-of-16-patients-and-a-review-of-the-literature
#19
REVIEW
Giuseppe Di Bella, Fabrizio Mascia, Biagio Colori
OBJECTIVE: To evaluate the objective clinical response and the safety of the combined administration of somatostatin, melatonin, retinoids, vitamin D3, dopamine subtype 2 receptor (D2R) agonists and low doses of cyclophosphamide, associated with androgen ablation, in patients with a histological diagnosis of prostate adenocarcinoma (Pac). MATERIALS AND METHODS: The clinical data of 30 patients with non-invasive and metastatic prostate cancer, who attended our institution over a period of more than 5 years, were retrospectively reviewed...
2013: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/24376664/individual-variations-in-serum-melatonin-levels-through-time-implications-for-epidemiologic-studies
#20
RANDOMIZED CONTROLLED TRIAL
Leticia M Nogueira, Joshua N Sampson, Lisa W Chu, Kai Yu, Gerald Andriole, Timothy Church, Frank Z Stanczyk, Jill Koshiol, Ann W Hsing
Melatonin, a marker for the circadian rhythm with serum levels peaking between 2AM and 5AM, is hypothesized to possess anti-cancer properties, making it a mechanistic candidate for the probable carcinogenic effect of circadian rhythm disruption. In order to weigh epidemiologic evidence on the association of melatonin with cancer, we must first understand the laboratory and biological sources of variability in melatonin levels measured in samples. Participants for this methodological study were men enrolled in the Prostate Lung Colorectal and Ovarian Cancer Screening Trial (PLCO)...
2013: PloS One
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