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young prehypertension

Shakia T Hardy, Katelyn M Holliday, Sujatro Chakladar, Joseph C Engeda, Norrina B Allen, Gerardo Heiss, Donald M Lloyd-Jones, Pamela J Schreiner, Christina M Shay, Danyu Lin, Donglin Zeng, Christy L Avery
Importance: Many studies have assessed racial/ethnic and sex disparities in the prevalence of elevated blood pressure (BP) from childhood to adulthood, yet few have examined differences in age-specific transitions between categories of BP over the life course in contemporary, multiracial/multiethnic populations. Objective: To estimate age, racial/ethnic, and sex-specific annual net transition probabilities between categories of BP using Markov modeling of cross-sectional data from the National Health and Nutrition Examination Survey...
April 19, 2017: JAMA Cardiology
Ju Young Jung, Sung Keun Park, Chang-Mo Oh, Jeong Gyu Kang, Joong-Myung Choi, Jae-Hong Ryoo, Jae-Hon Lee
Although hypertension is a clear risk factor for cardiovascular disease, how prehypertension and controlled hypertension influence left ventricular (LV) diastolic function and structure remain to be elucidated. Thus, this study was intended to investigate the link between LV diastolic dysfunction and structural changes in different categories of hypertension. A cohort of 52 111 Korean adults receiving echocardiograms was enrolled. The study population was stratified into five groups according to the following categories of hypertension and blood pressure (BP): normotensive (<120/80 mm Hg), prehypertensive (120-139/80-89 mm Hg), controlled hypertensive (<140/90 mm Hg), newly recognized hypertensive and uncontrolled hypertensive (⩾140/90 mm Hg)...
January 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
Anke Raaijmakers, Zhen-Yu Zhang, Jolien Claessens, Nicholas Cauwenberghs, Theun Pieter van Tienoven, Fang-Fei Wei, Lotte Jacobs, Elena Levtchenko, Steven Pauwels, Tatiana Kuznetsova, Karel Allegaert, Jan A Staessen
Low birth weight and prematurity are risk factors for hypertension in adulthood. Few studies in preterm or full-term born children reported on plasma renin activity (PRA). We tested the hypothesis that renin might modulate the incidence of hypertension associated with prematurity. We enrolled 93 prematurely born children with birth weight <1000 g and 87 healthy controls born at term, who were all examined at ≈11 years. Renal length and glomerular filtration rate derived from serum cystatin C were 0.28 cm (95% confidence interval, 0...
March 2017: Hypertension
Gontse G Mokwatsi, Aletta E Schutte, Ruan Kruger
OBJECTIVES: Vascular deterioration is suggested to occur earlier in black than white populations, thereby increasing their risk for developing hypertension. To establish whether this is the case, we compared different estimates of arterial stiffness in black and white children and investigated the links with body composition and advanced glycation end products (AGEs) as potential contributors. METHODS: We included 40 black and 41 white boys (aged 6-8 years) from similar schools and measured arterial stiffness [pulse wave velocity (PWV) in different arterial sections, systemic arterial compliance and carotid stiffness estimates], anthropometry as well as urinary pentosidine as a marker of AGEs...
January 18, 2017: Journal of Hypertension
Yogesh Saxena, Rani Gupta, Arsalan Moinuddin, Ravinder Narwal
CONTEXT: Accumulated moderate physical activity (PA) for 30 min in a day is the only recommended treatment of prehypertension. OBJECTIVE: We investigated autonomic modulation as a possible mechanism for the decrease in blood pressure (BP) during the rest periods in each 10 min session of PA. DESIGN SETTING AND PARTICIPANTS: We conducted a single-blind randomized multi-arm control trial on 40 prehypertensive (pre-HT) young male adults. METHODS: Participants were randomly divided by using random number table into four groups...
April 2016: Journal of Family Medicine and Primary Care
Sunandha Senthil, Subbalakshmi Narasajjana Krishnadasa
INTRODUCTION: High incidence of prehypertension is reported in medical undergraduates. Prehypertension may progress to hypertension and eventually cardiovascular disease, a leading cause of morbidity and mortality. Therefore, identifying the risk factors of hypertension in prehypertensive state may aid in effective control of blood pressure. AIM: To find whether clustering of known risk factors of hypertension or certain individual risk factors alone affect blood pressure in young adults...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
S Cacanyiova, A Berenyiova, F Kristek, M Drobna, K Ondrias, M Grman
The aorta plays an important role in blood pressure control so the early determination of its vasoactive properties could predict pathological changes in hypertension. The aim of study was to compare vasoactive properties and geometry of thoracic aorta (TA) and the participation of two vasoactive transmitters, nitric oxide (NO) and hydrogen sulphide (H2S), in TA tone regulation in young Wistar rats (WR) and spontaneously hypertensive rats (SHR). Four-weeks-old WR and SHR were used. Systolic blood pressure (sBP) was measured by plethysmography...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Qianqian Dong, Wenjuan Xing, Feng Fu, Zhenghua Liu, Jie Wang, Xiangyan Liang, Xuanxuan Zhou, Qian Yang, Wei Zhang, Feng Gao, Siwang Wang, Haifeng Zhang
Autophagy exists in vascular endothelial cells, but the relationship between autophagy and blood vessel dysfunction in hypertension remains elusive. This study aimed to investigate role of autophagy in vascular endothelial dysfunction in prehypertension and hypertension and the underlying mechanisms involved. Furthermore, we sought to determine if and how tetrahydroxystilbene glucoside (TSG), a resveratrol analogue and active ingredient of Polygonum multiflorum Thunb used for its cardiovascular protective properties in traditional Chinese medicine, influences vascular endothelial function...
2016: American Journal of Chinese Medicine
Asvini Subasinghe, John Wark, Alexandra Gorelik, Suzanne Garland
OBJECTIVE: The relationship between inflammation and prehypertension has never been documented in adolescent females in Australia, where obesity is prevalent. We aimed to investigate the association between high sensitivity C-Reactive Protein (hs-CRP), obesity and prehypertension in young Australian females. DESIGN AND METHOD: Women aged 16-25 years, living in Victoria, were randomly recruited via targeted Facebook advertising for the Young Female Health Initiative and Safe-D studies...
September 2016: Journal of Hypertension
Arturo Figueroa, Alexei Wong, Salvador J Jaime, Joaquin U Gonzales
PURPOSE OF REVIEW: L-Citrulline, either synthetic or in watermelon, may improve vascular function through increased L-arginine bioavailability and nitric oxide synthesis. This article analyses potential vascular benefits of L-citrulline and watermelon supplementation at rest and during exercise. RECENT FINDINGS: There is clear evidence that acute L-citrulline ingestion increases plasma L-arginine, the substrate for endothelial nitric oxide synthesis. However, the subsequent acute improvement in nitric oxide production and mediated vasodilation is inconsistent, which likely explains the inability of acute L-citrulline or watermelon to improve exercise tolerance...
January 2017: Current Opinion in Clinical Nutrition and Metabolic Care
Gopal Krushna Pal, Chandrasekaran Adithan, Gurusamy Umamaheswaran, Pravati Pal, Nivedita Nanda, Jagadeeswaran Indumathy, Avupati Naga Syamsunder
Though endothelial nitric oxide synthase (eNOS) gene polymorphism is documented in the causation of hypertension, its role in prehypertension has not been investigated. The present study was conducted in 172 subjects divided into prehypertensives (n = 57) and normotensives (n = 115). Cardiovascular (CV) parameters including baroreflex sensitivity (BRS) by continuous BP variability assessment and sympathovagal imbalance (SVI) by heart rate variability analysis were recorded. Biochemical parameters for insulin resistance (homeostatic model for assessment of insulin resistance), oxidative stress, lipid risk factors, renin, and inflammatory parameters were measured...
September 15, 2016: Journal of the American Society of Hypertension: JASH
Asvini Subasinghe, John Wark, Alexandra Gorelik, Suzanne Garland
OBJECTIVE: The relationship between inflammation and prehypertension has never been documented in adolescent females in Australia, where obesity is prevalent. We aimed to investigate the association between high sensitivity C-Reactive Protein (hs-CRP), obesity and prehypertension in young Australian females. DESIGN AND METHOD: Women aged 16-25 years, living in Victoria, were randomly recruited via targeted Facebook advertising for the Young Female Health Initiative and Safe-D studies...
September 2016: Journal of Hypertension
Cameron G McCarthy, Camilla F Wenceslau, Styliani Goulopoulou, Babak Baban, Takayuki Matsumoto, R Clinton Webb
BACKGROUND: Innate immune system responses to damage-associated molecular patterns (DAMPs) are involved in hypertension. However, the mechanisms of this contribution are not well understood. Circulating mitochondrial DNA is a DAMP that activates Toll-like receptor (TLR) 9 and is elevated in spontaneously hypertensive rats (SHR). Therefore, we hypothesized that lysosomotropic agent chloroquine (CQ) would impair TLR9 signaling, as well as prevent the development of hypertension and immune cell recruitment to the vasculature, in SHR...
February 2017: American Journal of Hypertension
Vernon Bond, Bryan H Curry, Richard G Adams, Thomas Obisesan, Sudhakar Pemminati, Vasavi R Gorantla, Kishan Kadur, Richard M Millis
BACKGROUND: Hypertensive individuals are known to exhibit greater increases in blood pressure during an isometric handgrip exercise (IHE) than their normotensive counterparts. AIM: This study tests the hypothesis that, compared to normotensive individuals, prehypertensive individuals exhibit an exaggerated response to IHE. MATERIALS AND METHODS: In this study, the effects of IHE were compared in matched prehypertensive vs. normotensive healthy African-American females...
June 2016: North American Journal of Medical Sciences
Mehmet Karaduman, Mustafa Aparci, Murat Unlu, Cengiz Ozturk, Sevket Balta, Turgay Celik
The prevalence of hypertension is increasing among young population worldwide. So there is an interest in detecting prehypertension and hypertension in childhood. We determined blood pressure (BP) recorded at a screening test in a young population. We retrospectively evaluated the medical records including systolic blood pressure (SBP), diastolic blood pressure (DBP), weight, height, and body mass index (BMI) of 685 male and 130 female apparently healthy adolescents. We evaluated the prevalence of BP categories: normotension, prehypertension, and hypertension...
August 4, 2016: Angiology
Mona Schaalan, Waleed Mohamed, Rania Rahmo
BACKGROUND: In practice, there is increasing recognition of the importance of hypothalamic pituitary adrenal axis in the cardiovascular disease progression. The association of brain natriuretic peptide with obesity and characteristics of the metabolic syndrome in adults and aged patients is well established, but that in pediatrics needs thorough elucidation. AIM: The aim of this study was to assess the association of hypothalamic pituitary adrenal axis mediators (cortisol and aldosterone) with plasma NT-pro β-type natriuretic peptide (NT-proBNP) levels on metabolic, immune-inflammatory and endothelial markers in young obese pediatric patients...
2016: Diabetology & Metabolic Syndrome
Beth A Staffileno, Jessica Zschunke, Mallery Weber, Lauren E Gross, Louis Fogg, Christy C Tangney
BACKGROUND: Reports describing successful recruiting of minority participants are available; however, they focus largely on traditional strategies. Internet and mobile devices are widely used, providing alternative approaches, yet less information is available describing the success of these approaches. OBJECTIVE: This article (1) evaluates the feasibility of using online advertising as a recruiting modality for a healthy lifestyle behavior change intervention targeting young African American women and (2) describes lessons learned to better inform researchers for future directions...
July 13, 2016: Journal of Cardiovascular Nursing
Marlou La de Kroon, Alet Wijga, Yvonne Vergouwe, Martijn W Heijmans, Vincent Wv Jaddoe, Jos Wr Twisk, Hein Raat
BACKGROUND: Dynamic risk estimations may enable targeting primary prevention of overweight and overweight-related adverse cardiometabolic outcome in later life, potentially serving as a valuable addition to universal primary prevention. This approach seems particularly promising in young children, as body mass index (BMI) changes at a young age are highly predictive of these outcomes, and parental lifestyle interventions at a young age are associated with improved long-term outcome. OBJECTIVE: This paper describes the design of our study, which aims to develop digitized tools that can be implemented in the Dutch Child Health Care (CHC) system or by pediatricians for children up to 6 years of age...
2016: JMIR Research Protocols
Wilby Williamson, Charlie Foster, Hamish Reid, Paul Kelly, Adam James Lewandowski, Henry Boardman, Nia Roberts, David McCartney, Odaro Huckstep, Julia Newton, Helen Dawes, Stephen Gerry, Paul Leeson
Previous studies report benefits of exercise for blood pressure control in middle age and older adults, but longer-term effectiveness in younger adults is not well established. We performed a systematic review and meta-analysis of published randomized control trials with meta-regression of potential effect modifiers. An information specialist completed a comprehensive search of available data sources, including studies published up to June 2015. Authors applied strict inclusion and exclusion criteria to screen 9524 titles...
July 2016: Hypertension
M Doménech, J Sobrino
No abstract text is available yet for this article.
July 2016: Hipertensión y Riesgo Vascular
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