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https://www.readbyqxmd.com/read/28734670/population-health-and-regional-variations-of-disease-burden-in-japan-1990-2015-a-systematic-subnational-analysis-for-the-global-burden-of-disease-study-2015
#1
Shuhei Nomura, Haruka Sakamoto, Scott Glenn, Yusuke Tsugawa, Sarah K Abe, Md M Rahman, Jonathan C Brown, Satoshi Ezoe, Christina Fitzmaurice, Tsuyoshi Inokuchi, Nicholas J Kassebaum, Norito Kawakami, Yosuke Kita, Naoki Kondo, Stephen S Lim, Satoshi Maruyama, Hiroaki Miyata, Meghan D Mooney, Mohsen Naghavi, Tomoko Onoda, Erika Ota, Yuji Otake, Gregory A Roth, Eiko Saito, Takahiro Tabuchi, Yohsuke Takasaki, Tadayuki Tanimura, Manami Uechi, Theo Vos, Haidong Wang, Manami Inoue, Christopher J L Murray, Kenji Shibuya
BACKGROUND: Japan has entered the era of super-ageing and advanced health transition, which is increasingly putting pressure on the sustainability of its health system. The level and pace of this health transition might vary across regions within Japan and concern is growing about increasing regional variations in disease burden. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides a comprehensive, comparable framework. We used data from GBD 2015 with the aim to quantify the burden of disease and injuries, and to attribute risk factors in Japan at a subnational, prefecture-level...
July 19, 2017: Lancet
https://www.readbyqxmd.com/read/28734587/computed-tomography-predict-regression-of-coronary-artery-aneurysm-in-patients-with-kawasaki-disease
#2
Po-Ting Chen, Ming-Tai Lin, Yih-Sharng Chen, Shyh-Jye Chen, Mei-Hwan Wu
BACKGROUND/PURPOSE: The study evaluated possible factors influencing the regression of coronary artery aneurysm (CAA) in patients with Kawasaki disease (KD) through electrocardiographically gated cardiac computed tomography (CT). METHODS: 18 patients with KD exhibited CAAs in at least 2 CT examinations conducted from December 2004 to September 2015, and 37 aneurysms were observed. Every aneurysm was corrected through the descending aorta at the origin level of the left main coronary artery under a normal distribution and measured under a fixed window level...
July 19, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28734106/insecticide-resistance-in-trialeurodes-vaporariorum-populations-and-novel-diagnostics-for-kdr-mutations
#3
Despoina Evr Kapantaidaki, Eldem Sadikoglou, Dimitra Tsakireli, Vasileios Kampanis, Marianna Stavrakaki, Corinna Schorn, Aris Ilias, Maria Riga, George Tsiamis, Ralf Nauen, George Skavdis, John Vontas, Anastasia Tsagkarakou
BACKGROUND: Neonicotinoids, pyrethroids and ketoenols, are currently used for the control of Trialeurodes vaporariorum (Hemiptera: Aleyrodidae). In this study, insecticide resistance status and mechanisms were investigated by classical bioassays and molecular techniques. RESULTS: Dose response bioassays were performed on 19 Greek populations, among the 35 different whitefly populations used for the whole analysis. Resistance factors scaled up to 207-, 4657- and 59- fold, for imidacloprid, bifenthrin and spiromesifen, respectively...
July 22, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28732167/quantum-transport-and-subband-structure-of-modulation-doped-gaas-alas-core-superlattice-nanowires
#4
Dominik Irber, Jakob Seidl, Damon James Carrad, Jonathan Becker, Nari Jeon, Bernhard Loitsch, Julia Winnerl, Sonja Matich, Markus Döblinger, Yang Tang, Stefanie Morkötter, Gerhard Abstreiter, Jonathan J Finley, M Grayson, Lincoln Lauhon, Gregor Koblmueller
Modulation-doped III-V semiconductor nanowire (NW) heterostructures have recently emerged as promising candidates to host high-mobility electron channels for future high-frequency, low-energy transistor technologies. The one-dimensional geometry of NWs also makes them attractive for studying quantum confinement effects. Here, we report correlated investigations into the discrete electronic sub-band structure of confined electrons in the channel of Si delta-doped GaAs/AlAs core-superlattice NW heterostructures and the associated signatures in low-temperature transport...
July 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28730802/sensing-single-molecule-penetration-into-nanopores-pushing-the-time-resolution-to-the-diffusion-limit
#5
Igor Bodrenko, Jiajun Wang, Samuele Salis, Mathias Winterhalter, Matteo Ceccarelli
To quantify small molecule penetration into and eventually permeation through nanopores, we applied an improved excess-noise analysis of the ion current fluctuation caused by entering molecules. The kinetic parameters of substrate entry and leave are derived from a two-state Markov model, analyzing the substrate concentration depen- dence of the average ion current and its variance. Including filter corrections allows one to detect the transition rates beyond the cutoff frequency, fc, of the instrumental ion-current filter...
July 21, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28729167/protection-against-cholera-from-killed-whole-cell-oral-cholera-vaccines-a-systematic-review-and-meta-analysis
#6
Qifang Bi, Eva Ferreras, Lorenzo Pezzoli, Dominique Legros, Louise C Ivers, Kashmira Date, Firdausi Qadri, Laura Digilio, David A Sack, Mohammad Ali, Justin Lessler, Francisco J Luquero, Andrew S Azman
BACKGROUND: Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges for public health decision making. We did a systematic review and meta-analysis to generate average estimates of kOCV efficacy and direct effectiveness from the available literature. METHODS: For this systematic review and meta-analysis, we searched PubMed, Embase, Scopus, and the Cochrane Review Library on July 9, 2016, and ISI Web of Science on July 11, 2016, for randomised controlled trials and observational studies that reported estimates of direct protection against medically attended confirmed cholera conferred by kOCVs...
July 17, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28728815/the-structural-basis-for-sensing-by%C3%A2-the-piezo1-protein
#7
W Li, N Gao, M Yang
Mechanotransduction is one of the processes by which cells sense and convert mechanical stimuli into biological signals. Experimental data from various species have revealed crucial roles for mechanotransduction in organ development and a plethora of physiological activities. Piezo proteins have recently been identified as the long-sought-after mechanically activated cation channels in eukaryotes. The architecture of mouse Piezo1 (mPiezo1) channel determined by cryoelectron microscopic single-particle analysis at medium resolution yielded important insights into the mechanical force sensing mechanism...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28725938/declining-radiation-dose-of-coronary-computed-tomography-angiography-german-cardiac-ct-registry-experience-2009-2014
#8
Axel Schmermund, Mohamed Marwan, Jörg Hausleiter, Sebastian Barth, Oliver Bruder, Sebastian Kerber, Grigorius Korosoglou, Alexander Leber, Werner Moshage, Stephen Schröder, Steffen Schneider, Jochen Senges, Stephan Achenbach
BACKGROUND: Coronary computed tomography angiography (CTA) is increasingly used as a test to rule out coronary artery disease (CAD) in patients with a low to intermediate pre-test probability of the disease. We used the database of the German CT registry, collected between 2009 and 2014 in a broad patient population, to analyze contemporary radiation dose associated with coronary CTA in clinical practice. PATIENTS AND METHODS: The prospective observational registry included a total of 7061 patients ≥18 years, referred to 12 participating centers for a clinically indicated cardiac CT examination...
July 19, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28723609/failure-analysis-of-eleven-gates-glidden-drills-that-fractured-intraorally-during-post-space-preparation-a-retrieval-analysis-study
#9
Youssef S Al Jabbari, Raymond Fournelle, Sara M Al Taweel, Spiros Zinelis
The purpose of this study was to determine the failure mechanism of clinically failed Gates Glidden (GG) drills. Eleven retrieved GG drills (sizes #1 to #3) which fractured during root canal preparation were collected and the fracture location was recorded based on macroscopic observation. All fracture surfaces were investigated by a SEM. Then the fractured parts were embedded in acrylic resin and after metallographic preparation, the microstructure and elemental composition was evaluated by SEM and EDS. The Vickers hardness (HV) of all specimens was also determined...
July 19, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28720714/maxi-k-channel-bkca-activity-veils-the-myogenic-tone-of-mesenteric-artery-in-rats
#10
Eun Yeong Suh, Ming Zhe Yin, Haiyue Lin, Yin Hua Zhang, Hae Young Yoo, Sung Joon Kim
Arterioles and small arteries change their tone in response to transmural pressure changes, called myogenic tone (MT). In comparison to the branches of cerebral arteries (CA) showing prominent MT, the third branches of mesenteric arteries (MA) with similar diameters show weaker MT Here, we aimed to analyze the electrophysiological differences responsible for the weaker MT in MA (MTMA) than MT in CA (MTCA). We measured ionic current using patch clamp in isolated MA smooth muscle cells (MASMCs) and CA smooth muscle cells (CASMCs) of rats...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28720382/activated-leukocyte-cell-adhesion-molecule-is-involved-in-excitatory-synaptic-transmission-and-plasticity-in-the-rat-spinal-dorsal-horn
#11
Eun-Sung Park, Sang-Min Jeon, Haein Weon, Hee-Jung Cho, Dong-Ho Youn
Activated leukocyte cell adhesion molecule (ALCAM), a member of type I transmembrane immunoglobulin superfamily of cell adhesion molecule, is expressed in the surface membrane of various cell types including neurons. In the spinal cord dorsal horn (DH), the first gate for the sensory and pain transmission to the brain, the expression and function of ALCAM have not been known yet. Therefore, we here investigate the synaptic function of ALCAM in the substantia gelatinosa (lamina II) of the spinal DH, as well as its expression in the DH...
July 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28719621/security-analysis-and-enhanced-user-authentication-in-proxy-mobile-ipv6-networks
#12
Dongwoo Kang, Jaewook Jung, Donghoon Lee, Hyoungshick Kim, Dongho Won
The Proxy Mobile IPv6 (PMIPv6) is a network-based mobility management protocol that allows a Mobile Node(MN) connected to the PMIPv6 domain to move from one network to another without changing the assigned IPv6 address. The user authentication procedure in this protocol is not standardized, but many smartcard based authentication schemes have been proposed. Recently, Alizadeh et al. proposed an authentication scheme for the PMIPv6. However, it could allow an attacker to derive an encryption key that must be securely shared between MN and the Mobile Access Gate(MAG)...
2017: PloS One
https://www.readbyqxmd.com/read/28718848/label-free-high-throughput-holographic-screening-and-enumeration-of-tumor-cells-in-blood
#13
Dhananjay Kumar Singh, Caroline C Ahrens, Wei Li, Siva A Vanapalli
We introduce inline digital holographic microscopy (in-line DHM) as a label-free technique for detecting tumor cells in blood. The optimized DHM platform fingerprints every cell flowing through a microchannel at 10 000 cells per second, based on three features - size, maximum intensity and mean intensity. To identify tumor cells in a background of blood cells, we developed robust gating criteria using machine-learning approaches. We established classifiers from the features extracted from 100 000-cell training sets consisting of red blood cells, peripheral blood mononuclear cells and tumor cell lines...
July 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28718820/a-transcriptomic-survey-of-ion-channel-based-conotoxins-in-the-chinese-tubular-cone-snail-conus-betulinus
#14
Yu Huang, Chao Peng, Yunhai Yi, Bingmiao Gao, Qiong Shi
Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based on the previous datasets of four transcriptomes from three venom ducts and one venom bulb, we explored ion channel-based conotoxins and predicted their related ion channel receptors. Homologous analysis was also performed for the most abundant ion channel protein, voltage-gated potassium (Kv; with Kv1...
July 18, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28716951/a-calcium-diacylglycerol-stimulated-protein-kinase-c-c-elegans-pkc-2-links-thermal-signals-to-learned-behavior-by-acting-in-a-sensory-neuron-and-intestinal-cells
#15
Marianne Land, Charles S Rubin
Ca(2+) and diacylglycerol (DAG) activated protein kinase C (cPKC) promotes learning and behavioral plasticity. However, knowledge of in vivo regulation and exact functions of cPKCs that affect behavior is limited. We show that PKC-2, a C. elegans cPKC, is essential for a complex behavior, thermotaxis. C. elegans memorizes a nutrient-associated cultivation temperature (Tc) and migrates along Tc within a 17-25°C gradient. pkc-2 gene disruption abrogated thermotaxis; a PKC-2 transgene, driven by endogenous pkc-2 promoters, restored thermotaxis behavior in pkc-2(-/-) animals...
July 17, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28716350/progress-and-priorities-for-reproductive-maternal-newborn-and-child-health-in-kenya-a-countdown-to-2015-country-case-study
#16
Emily C Keats, Anthony Ngugi, William Macharia, Nadia Akseer, Emma Nelima Khaemba, Zaid Bhatti, Arjumand Rizvi, John Tole, Zulfiqar A Bhutta
BACKGROUND: Progress in reproductive, maternal, newborn, and child health (RMNCH) in Kenya has been inconsistent over the past two decades, despite the global push to foster accountability, reduce child mortality, and improve maternal health in an equitable manner. Although several cross-sectional assessments have been done, a systematic analysis of RMNCH in Kenya was needed to better understand the push and pull factors that govern intervention coverage and influence mortality trends...
August 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28716022/crisis-resolution-and-home-treatment-stakeholders-views-on-critical-ingredients-and-implementation-in-england
#17
Nicola Morant, Brynmor Lloyd-Evans, Danielle Lamb, Kate Fullarton, Eleanor Brown, Beth Paterson, Hannah Istead, Kathleen Kelly, David Hindle, Sarah Fahmy, Claire Henderson, Oliver Mason, Sonia Johnson
BACKGROUND: Crisis resolution teams (CRTs) can provide effective home-based treatment for acute mental health crises, although critical ingredients of the model have not been clearly identified, and implementation has been inconsistent. In order to inform development of a more highly specified CRT model that meets service users' needs, this study used qualitative methods to investigate stakeholders' experiences and views of CRTs, and what is important in good quality home-based crisis care...
July 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28712766/-a-call-for-a-clear-assignment-a-focus-group-study-of-the-ambulance-service-in-sweden-as-experienced-by-present-and-former-employees
#18
Helena Rosén, Johan Persson, Andreas Rantala, Lina Behm
AIM: The aim was to explore the ambulance service as experienced by present and former employees. BACKGROUND: Over the last decade, the number of ambulance assignments has increased annually by about 10%, and as many as 50% of all ambulance assignments are considered non-urgent. This raises questions about which assignments the Ambulance Service (AS) is supposed to deal with. DESIGN/METHOD: Data were collected from three focus group interviews with a total of 18 present and former employees of the Swedish AS...
July 13, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28712714/spinning-slithole-collimation-for-high-sensitivity-small-animal-spect-design-and-assessment-using-gate-simulation
#19
Hojjat Mahani, Gholamreza Raisali, Alireza Kamali-Asl, Mohammad Reza Ay
PURPOSE: While traditional collimations are widely used in preclinical SPECT imaging, they usually suffer from possessing a low system sensitivity leading to noisy images. In this study, we are aiming at introducing a novel collimator, the slithole, offering a superior resolution-sensitivity tradeoff for small animal SPECT. METHODS: The collimator was designed for a molecular SPECT scanner, the HiReSPECT. The slithole is a knife-edge narrow long aperture extended across long-axis of the camera's head...
July 13, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28710871/detection-and-quantification-of-coronary-calcium-from-dual-energy-chest-x-rays-phantom-feasibility-study
#20
Bo Zhou, Di Wen, Katelyn Nye, Robert C Gilkeson, Brendan Eck, David Jordan, David L Wilson
PURPOSE: We have demonstrated the ability to identify coronary calcium, a reliable biomarker of coronary artery disease, using non-gated, 2-shot, dual energy (DE) chest x-ray imaging. Here we will use digital simulations, backed up by measurements, to characterize DE calcium signals and the role of potential confounds such as beam hardening, x-ray scatter, cardiac motion, and pulmonary artery pulsation. For the DE calcium signal, we will consider quantification, as compared to CT calcium score, and visualization...
July 15, 2017: Medical Physics
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