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https://www.readbyqxmd.com/read/28814523/screening-of-fda-approved-drugs-for-inhibitors-against-japanese-encephalitis-virus-infection
#1
Shaobo Wang, Yang Liu, Jiao Guo, Peilin Wang, Leike Zhang, Gengfu Xiao, Wei Wang
Japanese encephalitis virus (JEV), an arthropod-borne flavivirus, is a major cause of acute viral encephalitis in humans. There is no approved drug available for JEV-specific treatment, and the vaccines are not effective against all clinical JEV isolates. Herein, a high-throughput screening was performed against JEV from an FDA-approved drug library. Five hit drugs were identified that inhibited JEV infection with a selective index > 10. Antiviral activities of these five hit drugs against other flavivirus, including Zika virus, were also validated...
August 16, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28812221/multimodal-neuroimaging-in-schizophrenia-description-and-dissemination
#2
C J Aine, H J Bockholt, J R Bustillo, J M Cañive, A Caprihan, C Gasparovic, F M Hanlon, J M Houck, R E Jung, J Lauriello, J Liu, A R Mayer, N I Perrone-Bizzozero, S Posse, J M Stephen, J A Turner, V P Clark, Vince D Calhoun
In this paper we describe an open-access collection of multimodal neuroimaging data in schizophrenia for release to the community. Data were acquired from approximately 100 patients with schizophrenia and 100 age-matched controls during rest as well as several task activation paradigms targeting a hierarchy of cognitive constructs. Neuroimaging data include structural MRI, functional MRI, diffusion MRI, MR spectroscopic imaging, and magnetoencephalography. For three of the hypothesis-driven projects, task activation paradigms were acquired on subsets of ~200 volunteers which examined a range of sensory and cognitive processes (e...
August 15, 2017: Neuroinformatics
https://www.readbyqxmd.com/read/28811247/pharmacological-analysis-of-poecilotheria-spider-venoms-in-mice-provides-clues-for-human-treatment
#3
Alexander Andreev-Andrievskiy, Anfisa Popova, Evgeniia Lagereva, Daniil Osipov, Antonina Berkut, Eugene Grishin, Alexander Vassilevski
Bites of tiger spiders belonging to Poecilotheria genus cause moderate to severe pain and long-lasting local or generalized muscle cramps in humans. Bites occur in regions of the spiders' natural habitat, India and Sri Lanka, but the popularity of these colorful tarantulas as pets leads to reports of envenomation cases worldwide. Treatment is predominantly symptomatic and often inadequate since there is almost no clinical or toxicology research data available, and physicians outside India or Sri Lanka typically have no experience in treating such cases...
August 12, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28808939/comparison-of-left-ventricular-shape-by-gated-spect-imaging-in-diabetic-and-nondiabetic-patients-with-normal-myocardial-perfusion-a-propensity-score-analysis
#4
Carmela Nappi, Valeria Gaudieri, Wanda Acampa, Roberta Assante, Emilia Zampella, Ciro Gabriele Mainolfi, Mario Petretta, Guido Germano, Alberto Cuocolo
BACKGROUND: Diabetes mellitus induces structural and functional cardiac alterations that can result in heart failure. Left ventricular (LV) shape is a dynamic component of cardiac geometry influencing its contractile function. However, few data are available comparing LV shape index in diabetic and nondiabetic patients without overt coronary artery disease after balancing for coronary risk factors. METHODS: We studied 1168 patients with normal myocardial perfusion and normal LV ejection fraction on stress gated single-photon emission computed tomography (SPECT) imaging...
August 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28808682/effects-of-population-dispersal-on-regional-signaling-networks-an-example-from-northern-iroquoia
#5
John P Hart, Jennifer Birch, Christian Gates St-Pierre
The dispersal of Iroquoian groups from St. Lawrence River valley during the 15th and 16th centuries A.D. has been a source of archaeological inquiry for decades. Social network analysis presented here indicates that sites from Jefferson County, New York at the head of the St. Lawrence River controlled interactions within regional social signaling networks during the 15th century A.D. Measures indicate that Jefferson County sites were in brokerage liaison positions between sites in New York and Ontario. In the network for the subsequent century, to which no Jefferson County sites are assigned, no single group took the place of Jefferson County in controlling network flow...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28807716/iritectol-g-a-novel-iridal-type-triterpenoid-from-iris-tectorum-displays-anti-epileptic-activity-in-vitro-through-inhibition-of-sodium-channels
#6
Chunlei Zhang, Juan Chen, Fang Zhao, Ruoyun Chen, Dequan Yu, Zhengyu Cao
Iritectol G, a novel iridal-type triterpenoid containing an uncommon tetrahydrofuran moiety, was isolated from the rhizomes of Iris tectorum. The structure was elucidated by comprehensive spectroscopic analysis. Iritectol G inhibited spontaneous and 4-aminopyridine-evoked calcium oscillations in primary cultured neocortical neurons with IC50 values of 8.2μM and 12.5μM, respectively. Further electrophysiological study demonstrated that iritectol G preferred to interact with inactivated state of voltage-gated sodium channel with an IC50 value of 7...
August 11, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28806716/efficient-hardware-implementation-of-the-subthalamic-nucleus-external-globus-pallidus-oscillation-system-and-its-dynamics-investigation
#7
Shuangming Yang, Xile Wei, Jiang Wang, Bin Deng, Chen Liu, Haitao Yu, Huiyan Li
Modeling and implementation of the nonlinear neural system with physiologically plausible dynamic behaviors are considerably meaningful in the field of computational neuroscience. This study introduces a novel hardware platform to investigate the dynamical behaviors within the nonlinear subthalamic nucleus-external globus pallidus system. In order to reduce the implementation complexities, a hardware-oriented conductance-based subthalamic nucleus (STN) model is presented, which can reproduce accurately the dynamical characteristics of biological conductance-based STN cells...
July 26, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28802757/the-typhoid-vaccine-acceleration-consortium-tyvac-vaccine-effectiveness-study-designs-accelerating-the-introduction-of-typhoid-conjugate-vaccines-and-reducing-the-global-burden-of-enteric-fever-report-from-a-meeting-held-on-26-27-october-2016-oxford-uk
#8
James E Meiring, Malick Gibani
Typhoid fever is estimated to cause between 11.9-26.9 million infections globally each year with 129,000-216,510 deaths. Access to improved water sources have reduced disease incidence in parts of the world but the use of efficacious vaccines is seen as an important public health tool for countries with a high disease burden. A new generation of Vi typhoid conjugate vaccines (TCVs), licensed for use in young children and expected to provide longer lasting protection than previous vaccines, are now available...
August 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28801630/the-role-of-snell-s-law-for-a-magnonic-majority-gate
#9
Naoki Kanazawa, Taichi Goto, Koji Sekiguchi, Alexander B Granovsky, Caroline A Ross, Hiroyuki Takagi, Yuichi Nakamura, Hironaga Uchida, Mitsuteru Inoue
In the fifty years since the postulation of Moore's Law, the increasing energy consumption in silicon electronics has motivated research into emerging devices. An attractive research direction is processing information via the phase of spin waves within magnonic-logic circuits, which function without charge transport and the accompanying heat generation. The functional completeness of magnonic logic circuits based on the majority function was recently proved. However, the performance of such logic circuits was rather poor due to the difficulty of controlling spin waves in the input junction of the waveguides...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28798746/automated-analysis-of-flow-cytometry-data-to-reduce-inter-lab-variation-in-the-detection-of-major-histocompatibility-complex-multimer-binding-t-cells
#10
Natasja Wulff Pedersen, P Anoop Chandran, Yu Qian, Jonathan Rebhahn, Nadia Viborg Petersen, Mathilde Dalsgaard Hoff, Scott White, Alexandra J Lee, Rick Stanton, Charlotte Halgreen, Kivin Jakobsen, Tim Mosmann, Cécile Gouttefangeas, Cliburn Chan, Richard H Scheuermann, Sine Reker Hadrup
Manual analysis of flow cytometry data and subjective gate-border decisions taken by individuals continue to be a source of variation in the assessment of antigen-specific T cells when comparing data across laboratories, and also over time in individual labs. Therefore, strategies to provide automated analysis of major histocompatibility complex (MHC) multimer-binding T cells represent an attractive solution to decrease subjectivity and technical variation. The challenge of using an automated analysis approach is that MHC multimer-binding T cell populations are often rare and therefore difficult to detect...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28797167/electron-transfer-gated-ion-transport-in-carbon-nanopipettes
#11
Dengchao Wang, Michael V Mirkin
Coating the inner wall of a quartz nanopipette with a thin layer of carbon yields a nanopore with the tunable surface charge and chemical state for resistive-pulse and rectification sensing. Herein we report the experimental study and modeling of the electron-transfer gated ion transport processes in carbon nanopipettes. The potential of the unbiased carbon layer can be tuned by adding very low (sub-nM) concentrations of redox species to the solution via bipolar electrochemistry. The potential of carbon determines the electrical double layer structure that, in turn, affects the ionic transport processes...
August 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28795510/cngb3-mutation-spectrum-including-copy-number-variations-in-485-achromatopsia-patients
#12
Anja Kathrin Mayer, Caroline Van Cauwenbergh, Christine Rother, Britta Baumann, Peggy Reuter, Elfride De Baere, Bernd Wissinger, Susanne Kohl
Achromatopsia is a rare autosomal recessive cone disorder characterized by color vision defects, photophobia, nystagmus and severely reduced visual acuity. The disease is caused by mutations in genes encoding crucial components of the cone phototransduction cascade (CNGA3, CNGB3, GNAT2, PDE6C, and PDE6H) or in ATF6, involved in the unfolded protein response. CNGB3 encoding the beta subunit of the cyclic nucleotide-gated ion channel in cone photoreceptors is the major achromatopsia gene. Here, we present a comprehensive spectrum of CNGB3 mutations and their prevalence in a cohort of 1,074 independent families clinically diagnosed with achromatopsia...
August 10, 2017: Human Mutation
https://www.readbyqxmd.com/read/28793859/investigating-knockdown-resistance-kdr-mechanism-against-pyrethroids-ddt-in-the-malaria-vector-anopheles-funestus-across-africa
#13
Helen Irving, Charles S Wondji
BACKGROUND: Understanding the molecular basis of insecticide resistance is key to improve the surveillance and monitoring of malaria vector populations under control. In the major malaria vector Anopheles funestus, little is currently known about the role of the knockdown resistance (kdr) mechanism. Here, we investigated the presence and contribution of knockdown resistance (kdr) to pyrethroids/DDT resistance observed in Anopheles funestus across Africa. RESULTS: Pyrosequencing genotyping and sequencing of the voltage gated sodium channel (VGSC) gene did not detect the common L1014F mutation in field collected An...
August 9, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28790148/the-actions-of-drug-combinations-on-the-gabaa-receptor-manifest-as-curvilinear-isoboles-of-additivity
#14
Daniel J Shin, Allison L Germann, Joseph H Steinbach, Gustav Akk
Drug interactions are often analyzed in terms of isobolograms. In the isobologram, the line connecting the axial points corresponding to the concentrations of two different drugs that produce an effect of the same magnitude is termed an isobole of additivity. Although the isobole of additivity can be a straight line in some special cases, previous work has found that it is curvilinear when the two drugs differ in their maximal effects or Hill slopes. Modulators of transmitter-gated ion channels have a wide range of maximal effects as well as Hill slopes, suggesting that the isoboles for drug actions on ion channel function are not linear...
August 8, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28775320/modulation-of-activation-and-inactivation-by-ca-2-and-2-apb-in-the-pore-of-an-archetypal-trpm-channel-from-nematostella-vectensis
#15
Frank J P Kühn, Winking Mathis, Kühn Cornelia, Daniel C Hoffmann, Andreas Lückhoff
The archetypal TRPM2-like channel of the sea anemone Nematostella vectensis is gated by ADPR like its human orthologue but additionally exhibits properties of other vertebrate TRPM channels. Thus it can help towards an understanding of gating and regulation of the whole subfamily. To elucidate further the role of Ca(2+) as a co-factor of ADPR, we exploited 2-aminoethyl diphenylborinate (2-APB), previously shown to exert either inhibitory or stimulatory effects on diverse TRPM channels, or both in a concentration-dependent manner...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774948/molecular-and-functional-characterization-of-the-voltage-gated-proton-channel-in-zebrafish-neutrophils
#16
Adisorn Ratanayotha, Takafumi Kawai, Shin-Ichi Higashijima, Yasushi Okamura
Voltage-gated proton channels (Hv1/VSOP) are expressed in various cells types, including phagocytes, and are involved in diverse physiological processes. Although hvcn1, the gene encoding Hv1, has been identified across a wide range of species, most of the knowledge about its physiological function and expression profile is limited to mammals. In this study, we investigated the basic properties of DrHv1, the Hv1 ortholog in zebrafish (Danio rerio) which is an excellent animal model owing to the transparency, as well as its functional expression in native cells...
August 2017: Physiological Reports
https://www.readbyqxmd.com/read/28773242/low-concentration-indium-doping-in-solution-processed-zinc-oxide-films-for-thin-film-transistors
#17
Xue Zhang, Hyeonju Lee, Jung-Hyok Kwon, Eui-Jik Kim, Jaehoon Park
We investigated the influence of low-concentration indium (In) doping on the chemical and structural properties of solution-processed zinc oxide (ZnO) films and the electrical characteristics of bottom-gate/top-contact In-doped ZnO thin-film transistors (TFTs). The thermogravimetry and differential scanning calorimetry analysis results showed that thermal annealing at 400 °C for 40 min produces In-doped ZnO films. As the In content of ZnO films was increased from 1% to 9%, the metal-oxygen bonding increased from 5...
July 31, 2017: Materials
https://www.readbyqxmd.com/read/28773037/bias-stress-and-temperature-impact-on-ingazno-tfts-and-circuits
#18
Jorge Martins, Pydi Bahubalindruni, Ana Rovisco, Asal Kiazadeh, Rodrigo Martins, Elvira Fortunato, Pedro Barquinha
This paper focuses on the analysis of InGaZnO thin-film transistors (TFTs) and circuits under the influence of different temperatures and bias stress, shedding light into their robustness when used in real-world applications. For temperature-dependent measurements, a temperature range of 15 to 85 °C was considered. In case of bias stress, both gate and drain bias were applied for 60 min. Though isolated transistors show a variation of drain current as high as 56% and 172% during bias voltage and temperature stress, the employed circuits were able to counteract it...
June 21, 2017: Materials
https://www.readbyqxmd.com/read/28771312/multiplexing-engineered-receptors-for-multiparametric-evaluation-of-environmental-ligands
#19
Rachel M Hartfield, Kelly A Schwarz, Joseph J Muldoon, Neda Bagheri, Joshua N Leonard
Engineered cell-based therapies comprise a promising, emerging biomedical technology. Broad utilization of this strategy will require new approaches for implementing sophisticated functional programs, such as sensing and responding to the environment in a defined fashion. Towards this goal, we investigated whether our self-contained receptor and signal transduction system (MESA) could be multiplexed to evaluate extracellular cues, with a focus on elucidating principles governing the integration of such engineered components...
August 3, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28770919/unconventional-magnetic-anisotropy-in-one-dimensional-rashba-system-realized-by-adsorbing-gd-atom-on-zigzag-graphene-nanoribbons
#20
Zhenzhen Qin, Guangzhao Qin, Bin Shao, Xu Zuo
The Rashba effect, a spin splitting in electronic band structures, attracts much attention for potential applications in spintronics with no requirement of an external magnetic field. Realizing a one-dimensional (1D) Rashba system is a big challenge due to the difficulties of growing high-quality heavy-metal nanowires or introducing strong spin-orbit coupling (SOC) and broken inversion symmetry in flexible materials. Here, based on first-principles calculations, we propose a pathway to realize the Rashba spin-split by adsorbing Gd atom on zigzag graphene nanoribbons (Gd-ZGNR) and further investigate the magnetic anisotropy energy (MAE)...
August 3, 2017: Nanoscale
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