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JOURNAL ARTICLE
Jerzy Pręgowski, Radosław Pracoń, Aleksandra Mioduszewska, Jarosław Skowroński, Lars Sondergaard, Gary S Mintz, Davide Capodanno, Sang-Wook Kim, Ole De Baker, Piotr Waciński, Wojciech Wojakowski, Adam Rdzanek, Marek Grygier, Michał Chmielecki, Luis Nombela Franco, Patrycjusz Stokłosa, Bohdan Firek, Magdalena Marczak, Barbara Miłosz, Zbigniew Chmielak, Marcin Demkow, Adam Witkowski
BACKGROUND: Both transcatheter edge-to-edge repair (TEER) of mitral regurgitation or left atrial appendage closure (LAAC) require periprocedural anticoagulation with unfractionated heparin (UFH) that is administered either before or immediately after transseptal puncture (TSP). The optimal timing of UFH administration (before or after TSP) is unknown. The Strategy To Optimize PeriproCeduraL AnticOagulation in Structural Transseptal Interventions trial (STOP CLOT Trial) was designed to determine if early anticoagulation is effective in reducing ischemic complications without increasing the risk of periprocedural bleeding...
February 22, 2024: American Heart Journal
#22
JOURNAL ARTICLE
Carmen Rosa Cerron-Vela, Luis Octavio Tierradentro-García, Zekordavar Lavadka Rimba, Savvas Andronikou
PURPOSE: Alagille syndrome (ALGS) is a multisystem autosomal dominant disorder with highly variable expression. Intracranial arterial and venous anomalies have a reported prevalence of 30-40% and can increase the risk of stroke by 16%. Few reports document the frequency and evolution of cerebrovascular abnormalities (CVAs) in children with ALGS. We aimed to define the spectrum, frequency, and evolution of CVAs in a series of children with ALGS using magnetic resonance angiography (MRA)...
February 24, 2024: Neuroradiology
#23
JOURNAL ARTICLE
Parvaneh Layegh, Lida Jarahi, Ehsan Hassannejad, Marziye Arab
BACKGROUND AND AIM: The present study investigated the correlation between vertebral artery hypoplasia and fetal-type variations of posterior cerebral arteries with stroke patterns and imaging findings in individuals with posterior circulation ischemic stroke. METHODS: In this cross-sectional study, patients with symptoms of acute ischemic stroke in the posterior circulation system referred to Ghaem Hospital in Mashhad between 2016 and 2022 were investigated. Demographic data, including age, gender, systemic diseases, history of previous stroke or transient ischemic attacks, and clinical manifestations of patients, were recorded using questionnaires and checklists from patient files...
February 2024: Health Science Reports
#24
JOURNAL ARTICLE
Yoshihiko Tachikawa, Yasunori Maki, Kento Ikeda, Hikaru Yoshikai, Nobuyuki Toyonari, Hiroshi Hamano, Naoya Chiwata, Kenji Suzuyama, Yukihiko Takahashi
PURPOSE: To investigate the feasibility of obtaining black-blood imaging with a large FOV from the neck to the aortic arch at 3 T using a newly modified Relaxation-Enhanced Angiography without Contrast and Triggering for Black-Blood Imaging (REACT-BB). MATERIALS AND METHODS: REACT-BB provides black-blood images by adjusting the inversion time (TI) in REACT to the null point of blood. The optimal TI for REACT-BB was investigated in 10 healthy volunteers with TI varied from 200 ms to 1400 ms...
February 6, 2024: Magnetic Resonance Imaging
#25
Taishi Honda, Masaki Ito, Haruto Uchino, Taku Sugiyama, Miki Fujimura
Moyamoya disease (MMD) is a rare idiopathic cerebrovascular disorder that causes transient ischemic attack (TIA) and ischemic stroke in the pediatric population. Herein, we report an extremely rare case of Moyamoya syndrome (MMS) and late-onset idiopathic aqueduct stenosis, a unique form of non-communicating hydrocephalus. A 17-year-old female presented with an intractable headache and occasional faintness. Pertinent medical history included a fourth ventricle epidermoid cyst without any evidence of aqueduct stenosis, which was surgically removed when she was two years of age...
2024: NMC Case Report Journal
#26
Abdullah Tawakul, Arturo R Toro, José Rafael Romero
INTRODUCTION: Cerebral microbleeds (CMBs) are deposits of hemosiderin-laden macrophages that can be visualized on T2-weighted MRI sequences as small, ovoid areas of signal void. These markers represent hemorrhagic cerebral small vessel disease and are usually subclinical and asymptomatic. In these cases, we present two patients who presented with symptomatic, acute CMBs. CASE DESCRIPTION: Case 1 involves a 70-year-old male with history of diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea...
2024: Cerebral circulation—cognition and behavior
#27
JOURNAL ARTICLE
Sarah T Pendlebury, Ramon Luengo-Fernandez, Anna Seeley, Matthew B Downer, Aubretia McColl, Peter M Rothwell
BACKGROUND: The increased risk of dementia after delirium and infection might be influenced by cerebral white matter disease (WMD). In patients with transient ischaemic attack (TIA) and minor stroke, we assessed associations between hospital admissions with delirium and 5-year dementia risk and between admissions with infection and dementia risk, stratified by WMD severity (moderate or severe vs absent or mild) on baseline brain imaging. METHODS: We included patients with TIA and minor stroke (National Institutes of Health Stroke Score <3) from the Oxford Vascular Study (OXVASC), a longitudinal population-based study of the incidence and outcomes of acute vascular events in a population of 94 567 individuals, with no age restrictions, attending eight general practices in Oxfordshire, UK...
February 2024: The Lancet. Healthy longevity
#28
JOURNAL ARTICLE
Francesco Melillo, Gregory Popusoi, Francesca Frecentese, Vittoria Miano, Alessandro Santoro, Tullio Tesorio, Eustaquio Maria Onorato
A 36-year-old woman suffered from an embolic stroke of an undetermined source documented by magnetic resonance imaging with residual right arm weakness. She underwent percutaneous patent foramen ovale (PFO) closure with an 18/25 mm device in another center. One year later, the patient suffered from a transient ischemic attack with dysarthria. She asked for a second opinion at our institution and a contrast-transthoracic (cTTE) /transesophageal echocardiography showed a large residual right-to-left shunt (RLS) through a still patent tunnel after PFO closure...
2024: International Heart Journal
#29
JOURNAL ARTICLE
Jun Sawada, Takayuki Katayama, Shiori Kikuchi-Takeguchi, Kohei Kano, Masato Saito, Nobuyuki Mitsui, Satoru Hiroshima, Manabu Kinoshita, Naoki Nakagawa
BACKGROUND: Cerebrovascular diseases in cancer patients significantly aggravate their condition and prognosis; therefore, prompt and accurate diagnosis and treatment are important. The purpose of this study was to investigate patient demographics, laboratory data, brain magnetic resonance imaging (MRI) findings, and prognosis among patients with stroke and cancer, especially cancer-associated ischemic stroke (CAIS). METHODS: We performed a retrospective, single-center study...
January 24, 2024: Neurological Sciences
#30
JOURNAL ARTICLE
Wenqiang Guo, Xingdong Wang, Xiaoguang Tong
OBJECTIVE: To investigate the clinical characteristics and treatment strategy of anterior circulation aneurysm presenting with cerebral ischemia. METHODS: We performed a retrospective review of patients with intracranial anterior circulation aneurysms presenting with cerebral ischemia examined in the Fifth Ward of the Neurosurgery Department of Tianjin Huanhu Hospital between September 2016 and September 2023. Data were reviewed for age, sex, presentation, type and size, location, treatment modalities, postoperative complications, clinical and imaging outcomes, and follow-up outcomes...
January 15, 2024: Journal of Craniofacial Surgery
#31
JOURNAL ARTICLE
Jung Hyun Kim, Youngrok Do
Patients with ischemic stroke and branch atheromatous disease (BAD) have worse neurological deficits and prognoses than those with small vessel occlusion (SVO). However, both disorders are forms of deep brain infarctions. This study aimed to investigate an MRI-based etiological classification for isolated pontine infarctions and assess differences in vascular risk factors and peripheral arterial disease among etiological subtypes. Consecutive data of patients admitted for acute ischemic stroke or transient ischemic attack between August 2016 and July 2019 were reviewed...
December 29, 2023: Medicine (Baltimore)
#32
JOURNAL ARTICLE
Petr Polidar, Barbora Paskova, Marta Karhanova, Martin Sin, Tomas Dornak, Petr Kanovsky, Zuzana Schreiberova, Petra Divisova, Tomas Veverka, David Franc, Daniel Sanak, Michal Kral
BACKGROUND: Large vessel carotid stenosis is a significant cause of ischaemic stroke. Indications for surgical revascularisation depend on the severity of the stenosis and clinical symptoms. However, mild symptoms such as TIA (Transient ischaemic attack), amaurosis fugax or minor stroke precede large strokes in only 15% of cases. AIM: The aim of this prospective study is to evaluate whether retinal perfusion is impacted in significant carotid stenosis. Automated retinal oximetry will be used to better assess perfusion in the post-stenotic basin...
January 3, 2024: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
#33
RANDOMIZED CONTROLLED TRIAL
Eric E Smith, Ashkan Shoamanesh, Lizhen Xu, Laura Heenan, Feryal Saad, Pablo Colorado, Chih-Hao Chen, Robin Lemmens, Gian Marco De Marchis, Valeria Caso, Jaime Masjuan, Teruyuki Hirano, Ivan Milanov, Bruce C V Campbell, Jean-Louis Mas, Stuart J Connolly, Hardi Mundl, Robert G Hart
BACKGROUND: Exploratory analysis of the phase 2 PACIFIC-Stroke (Program of Anticoagulation via Inhibition of FXIa by the Oral Compound BAY 2433334-Non-Cardioembolic Stroke) randomized trial suggested that asundexian, an oral factor XIa inhibitor, prevents recurrent stroke and transient ischemic attacks in patients with atherosclerotic stroke. In this post hoc exploratory analysis, we hypothesized that asundexian would be more effective in patients enrolled with large, multiple, or cortical acute infarcts on magnetic resonance imaging than in patients enrolled with a single small subcortical acute infarct, and asundexian would prevent incident cortical covert infarcts...
February 2024: Stroke; a Journal of Cerebral Circulation
#34
JOURNAL ARTICLE
Kenta Takakura, Eiji Takasawa, Tokue Mieda, Toshiki Tsukui, Kazuhiro Inomata, Yusuke Tomomatsu, Akira Honda, Hirotaka Chikuda
PURPOSE: Thoracic inlet angle (TIA) is a sagittal radiographic parameter with a constant value regardless of posture and is significantly correlated with the sagittal balance of the cervical spine. However, the practical use of TIA has not been studied. This study aimed to investigate the usefulness of the preoperative TIA for predicting the development of kyphotic deformity after cervical laminoplasty in comparison to the preoperative T1 slope (T1S). METHODS: A total of 98 patients who underwent cervical laminoplasty without preoperative kyphotic alignment were included (mean age, 73...
January 3, 2024: European Spine Journal
#35
JOURNAL ARTICLE
Laleh Zarrinkoob, Sanne Myrnäs, Anders Wåhlin, Anders Eklund, Jan Malm
BACKGROUND: Compromised cerebral blood flow can contribute to future ischemic events in patients with symptomatic carotid artery disease. However, there is limited knowledge of the effects on cerebral hemodynamics resulting from a reduced internal carotid artery (ICA) blood flow rate (BFR). PURPOSE: Investigate how reduced ICA-BFR, relates to BFR in the cerebral arteries. STUDY TYPE: Prospective. SUBJECTS: Thirty-eight patients, age 72 ± 6 years (11 female)...
January 2, 2024: Journal of Magnetic Resonance Imaging: JMRI
#36
MULTICENTER STUDY
Jonathan G Best, Gareth Ambler, Duncan Wilson, Houwei Du, Keon-Joo Lee, Jae-Sung Lim, Kay Cheong Teo, Henry Mak, Young Dae Kim, Tae-Jin Song, Derya Selcuk Demirelli, Masashi Nishihara, Masaaki Yoshikawa, Marta Kubacka, Annaelle Zietz, Rustam Al-Shahi Salman, Hans Rolf Jäger, Gregory Y H Lip, Leonidas Panos, Martina B Goeldlin, Lee-Anne Slater, Christopher Charles Karayiannis, Thanh G Phan, Maximilian Bellut, Jill Abrigo, Cyrus Cheng, Thomas W Leung, Winnie Chu, Francesca Chappell, Stephen D J Makin, Dianne H K van Dam-Nolen, M Eline Kooi, Sebastian Köhler, Julie Staals, Grégory Kuchcinski, Régis Bordet, Florian Dubost, Joanna M Wardlaw, Yannie O Y Soo, Felix Fluri, Velandai K Srikanth, Simon Jung, Nils Peters, Hideo Hara, Yusuke Yakushiji, Dilek Necioglu Orken, Ji-Hoe Heo, Gary Kui Kai Lau, Hee-Joon Bae, David J Werring
BACKGROUND AND OBJECTIVES: Visible perivascular spaces are an MRI marker of cerebral small vessel disease and might predict future stroke. However, results from existing studies vary. We aimed to clarify this through a large collaborative multicenter analysis. METHODS: We pooled individual patient data from a consortium of prospective cohort studies. Participants had recent ischemic stroke or transient ischemic attack (TIA), underwent baseline MRI, and were followed up for ischemic stroke and symptomatic intracranial hemorrhage (ICH)...
January 9, 2024: Neurology
#37
JOURNAL ARTICLE
Antoine Philippe Fournier, Marion Morvan, Sara Martinez de Lizarrondo, Maxime Gauberti
Following a stroke, an inflammatory response occurs, characterized by an increased blood-brain barrier permeability, expression of endothelial trafficking molecules, and infiltration of immune cells. Adhesion molecules expressed on activated brain endothelial cells are potential biomarkers of intraparenchymal inflammation. However, in current clinical practice, it is not possible to measure endothelial activation using clinically available imaging. Using targeted micro-sized particles of iron oxide (MPIO), immuno-MRI enables the detection of endothelial adhesion molecules at high resolution and, consequently, facilitates the detection of stroke-induced brain inflammation...
December 21, 2023: Neuroscience
#38
REVIEW
Pierluigi Merella, Gavino Casu, Paola Chessa, Enrico Atzori, Stefano Bandino, Gianluca Deiana
Non-valvular atrial fibrillation (AF) and cerebral amyloid angiopathy (CAA) are two common diseases in elderly populations. Despite the effectiveness of oral anticoagulant therapy in cardioembolic stroke prevention, intracranial hemorrhage represents the most serious complication of these therapies. Cerebral amyloid angiopathy is one of the main risk factors for spontaneous intracranial bleeding, and this risk is highly increased by age and concomitant antithrombotic therapies. Cerebral amyloid angiopathy can be silent for years and then manifest with clinical features simulating TIA (TIA-mimics) or stroke in AF patients, pushing clinicians to rapidly start VKAs or DOACs, thus increasing the risk of intracranial bleeding if the diagnosis of CAA was unknown...
December 15, 2023: Journal of Clinical Medicine
#39
JOURNAL ARTICLE
Dingqi Liu, Chenyang Zhao, Deng-Ling Zhao, Xiao-Hui Chen, Dan Zhou, Cheng Li
BACKGROUND: Intracranial atherosclerotic disease (ICAD) is one of the most common causes of ischemic stroke. The fetal-type posterior cerebral artery (FTP) affects intracranial collateral circulation, which is closely related to the occurrence and development of ICAD. Knowledge of the relationship between FTP and ICAD is important for developing treatment strategies for FTP patients diagnosed with atherosclerotic diseases. This study aims to quantitatively analyze the association between the FTP and intracranial atherosclerotic plaques using magnetic resonance vessel wall imaging (VW-MRI)...
December 1, 2023: Quantitative Imaging in Medicine and Surgery
#40
RANDOMIZED CONTROLLED TRIAL
Mukul Sharma, Carlos A Molina, Kazunori Toyoda, Daniel Bereczki, Shrikant I Bangdiwala, Scott E Kasner, Helmi L Lutsep, Georgios Tsivgoulis, George Ntaios, Anna Czlonkowska, Ashfaq Shuaib, Pierre Amarenco, Matthias Endres, Byung-Woo Yoon, David Tanne, Danilo Toni, Laetitia Yperzeele, Paul von Weitzel-Mudersbach, Gisele Sampaio Silva, Alvaro Avezum, Jesse Dawson, Daniel Strbian, Turgut Tatlisumak, Jens Eckstein, Sebastián F Ameriso, Joerg R Weber, Else Charlotte Sandset, Nana Goar Pogosova, Pablo M Lavados, Antonio Arauz, David Gailani, Hans-Christoph Diener, Richard A Bernstein, Charlotte Cordonnier, Anja Kahl, Grigor Abelian, Mark Donovan, Chahin Pachai, Danshi Li, Graeme J Hankey
BACKGROUND: People with factor XI deficiency have lower rates of ischaemic stroke than the general population and infrequent spontaneous bleeding, suggesting that factor XI has a more important role in thrombosis than in haemostasis. Milvexian, an oral small-molecule inhibitor of activated factor XI, added to standard antiplatelet therapy, might reduce the risk of non-cardioembolic ischaemic stroke without increasing the risk of bleeding. We aimed to estimate the dose-response of milvexian for recurrent ischaemic cerebral events and major bleeding in patients with recent ischaemic stroke or transient ischaemic attack (TIA)...
January 2024: Lancet Neurology
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