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https://www.readbyqxmd.com/read/29245117/gold-nanoflowers-synthesized-using-acanthopanacis-cortex-extract-inhibit-inflammatory-mediators-in-lps-induced-raw264-7-macrophages-via-nf-%C3%AE%C2%BAb-and-ap-1-pathways
#1
Sungeun Ahn, Priyanka Singh, Mi Jang, Yu-Jin Kim, Verónica Castro-Aceituno, Shakina Yesmin Simu, Yeon Ju Kim, Deok-Chun Yang
We reported the rapid synthesis (<8s) of gold nanoparticles at room temperature using Acanthopanacis cortex extract (A-AuNPs). We characterized the A-AuNPs using several analytical techniques and found that nano-flower type A-AuNPs, which are known to possess a coarse surface with a high surface to volume ratio, conferring these particles with high binding capacity for various biological molecules. After confirming the stability of the nanoparticles, we investigated the anti-inflammatory effect of A-AuNPs in LPS-stimulated RAW264...
November 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29244515/millisecond-self-assembly-of-stable-nano-dispersed-drug-formulations
#2
Vikram J Pansare, Aditya Rawal, Aaron Goodwin, Ron Beyerinck, Robert K Prud'homme, Dwayne T Friesen, Michael Grass, Annie Muske-Dukes, David T Vodak
We report the development of a new Spray-drying and Nanoparticle Assembly Process (SNAP), that enables the formation of stable, yet rapidly dissolving, sub-200 nm nano-crystalline particles within a high Tg glassy matrix. SNAP expands the class of drugs that Spray Dried Dispersion (SDD) processing can address to encompass highly crystalline, but modestly hydrophobic drugs that are difficult to process by conventional SDD. The process integrates rapid precipitation and spray drying within a custom designed nozzle to produce high supersaturations and precipitation of the drug and high Tg glassy polymer...
December 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29241764/determining-the-effects-of-green-chemistry-synthesized-ag-nisin-nanoparticle-on-macrophage-cells
#3
Masood Moein, Abbas Ali Imani Fooladi, Hamideh Mahmoodzadeh Hosseini
Bacteriocins are low molecular weight substances produced through post transcriptional changes. These molecules are easily degraded in mammalian gut by proteolytic enzymes especially protease. Nisin is a peptide with 34 aa and its structure contains a pentacyclic lanthionine and 4 beta metyllanthionine residues. Different formulations have been designed for nisin. Since "green synthesis" is a progressive method to prepare anti-microbial and anti-cancer compounds, this study aimed at green synthesis of nisin metal compounds to be used lower concentration still exerting nisin effects...
December 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29239854/synthesis-and-structural-characteristics-of-high-surface-area-tio2-aerogels-by-ultrasonic-assisted-sol-gel-method
#4
Qingge Feng, Huidong Cai, Haiying Lin, Siying Qin, Zheng Liu, Dachao Ma, Yuyang Ye
TiO2 aerogel is a unique three-dimensional porous nano-particle material with the characteristics of high specific surface area and good light transmittance. In this paper, a novel method involving ultrasonic-assisted sol-gel, solvent exchange, and vacuum drying was successfully developed to synthesis the TiO2 aerogel. The morphology and properties of the prepared TiO2 aerogels were characterized by Brunauer-Emmett-Teller theory (BET), X-ray diffraction (XRD), Field-emission scanning electron microscopy (FESEM), Energy dispersive spectroscopy (EDS), Thermogravimetric analysis-Differential thermal analysis (TGA-DTA), Fourier transform infrared spectroscopy (FTIR), and Raman spectroscopy...
December 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29236498/enhancement-of-anti-inflammatory-properties-of-nobiletin-in-macrophages-by-a-nano-emulsion-preparation
#5
Wenzhen Liao, Zhijun Liu, Tiantian Zhang, Suxia Sun, Jufeng Ye, Ziyin Li, Lianzhi Mao, Jiaoyan Ren
Many bioactive compounds are hydrophobic materials that are crystalline at ambient and body temperatures, which reduces their bioavailability and poses challenges to their successful incorporation into pharmaceuticals and functional foods. The aim of this study was to develop a nanoemulsion delivery system containing a hydrophobic crystalline bioactive component (nobiletin) to improve the anti-inflammatory activity. Nobiletin was incorporated into the oily phase, and the nanoemulsions were fabricated using high-speed and high-pressure homogenization...
December 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29236016/synthesis-of-mnfe2o4-and-mn3o4-magnetic-nano-composites-with-enhanced-properties-for-adsorption-of-cr-vi-artificial-neural-network-modeling
#6
Kartick Lal Bhowmik, Animesh Debnath, Ranendu Kumar Nath, Biswajit Saha
This study reports adsorptive removal of Cr(VI) by magnetic manganese ferrite and manganese oxide nano-particles (MnF-MO-NPs) composite from aqueous media. The X-ray diffraction pattern of MnF-MO-NPs revealed a polycrystalline nature with nanoscale crystallite size. The prepared adsorbent with high Brunauer-Emmett-Teller specific surface area of 100.62 m2/g and saturation magnetization of 30.12 emu/g exhibited maximum Cr(VI) removal at solution pH 2.0 and was easily separated from water under an external magnetic field...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29234454/pulmonary-injury-associated-with-spray-of-a-water-based-nano-sized-waterproofing-product-a-case-study
#7
Paul T J Scheepers, Lucie Masen-Poos, Frits G B G J van Rooy, Arné Oerlemans, Eline van Daalen, Robbert Cremers, Hera Lichtenbeld, Bonne Biesma, Jorid B Sørli, Ismo K Koponen, Søren Thor Larsen, Peder Wolkoff, Asger W Nørgaard
Background: In most reported cases of lung trauma with water proofing products, volatile organic compounds (VOC) have a prominent role. Here we report on a case involving ten workers exposed to a sprayed product containing nanoparticles in a water solution with only a few percent VOC. Case presentation: Ten workers suffered from respiratory symptoms following spray impregnation of hardwood furniture using a waterproofing product that contained positively charged fluorinated acrylate copolymer solid cores with a median diameter of 70 nm (1...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29234015/high-resolution-single-particle-zeta-potential-characterisation-of-biological-nanoparticles-using-tunable-resistive-pulse-sensing
#8
Robert Vogel, Anoop K Pal, Siddharth Jambhrunkar, Pragnesh Patel, Sachin S Thakur, Eduardo Reátegui, Harendra S Parekh, Paula Saá, Adonis Stassinopoulos, Murray F Broom
Physicochemical properties of nanoparticles, such as size, shape, surface charge, density, and porosity play a central role in biological interactions and hence accurate determination of these characteristics is of utmost importance. Here we propose tunable resistive pulse sensing for simultaneous size and surface charge measurements on a particle-by-particle basis, enabling the analysis of a wide spectrum of nanoparticles and their mixtures. Existing methodologies for measuring zeta potential of nanoparticles using resistive pulse sensing are significantly improved by including convection into the theoretical model...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232886/the-diverse-range-of-possible-cell-membrane-interactions-with-substrates-drug-delivery-interfaces-and-mobility
#9
REVIEW
Hyun-Sook Jang
The cell membrane has gained significant attention as a platform for the development of bio-inspired nanodevices due to its immune-evasive functionalities and copious bio-analogs. This review will examine several uses of cell membranes such as (i) therapeutic delivery carriers with or without substrates (i.e., nanoparticles and artificial polymers) that have enhanced efficiency regarding copious cargo loading and controlled release, (ii) exploiting nano-bio interfaces in membrane-coated particles from the macro- to the nanoscales, which would help resolve the biomedical issues involved in biological interfacing in the body, and (iii) its effects on the mobility of bio-moieties such as lipids and/or proteins in cell membranes, as discussed from a biophysical perspective...
December 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29232572/facile-biological-synthetic-strategy-to-morphologically-aligned-ceo2-zro2-core-nanoparticles-using-justicia-adhatoda-extract-and-ionic-liquid-enhancement-of-its-bio-medical-properties
#10
Nithya Pandiyan, Balaji Murugesan, Jegatheeswaran Sonamuthu, Selvam Samayanan, Sundrarajan Mahalingam
In this study, a typical green synthesis route has approached for CeO2/ZrO2 core metal oxide nanoparticles using ionic liquid mediated Justicia adhatoda extract. This synthesis method is carried out at simple room temperature condition to obtain the core metal oxide nanoparticles. XRD, SEM and TEM studies employed to study the crystalline and surface morphological properties under nucleation, growth, and aggregation processes. CeO2/ZrO2 core metal oxides display agglomerated nano stick-like structure with 20-45nm size...
November 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29231881/the-effect-of-different-coupling-agents-on-nano-zno-materials-obtained-via-the-sol-gel-process
#11
Violeta Purcar, Raluca Şomoghi, Sabina Georgiana Niţu, Cristian-Andi Nicolae, Elvira Alexandrescu, Ioana Cătălina Gîfu, Augusta Raluca Gabor, Hermine Stroescu, Raluca Ianchiş, Simona Căprărescu, Ludmila Otilia Cinteză
Hybrid nanomaterials based on zinc oxide were synthesized via the sol-gel method, using different silane coupling agents: (3-glycidyloxypropyl)trimethoxysilane (GPTMS), phenyltriethoxysilane (PhTES), octyltriethoxysilane (OTES), and octadecyltriethoxysilane (ODTES). Morphological properties and the silane precursor type effect on the particle size were investigated using dynamic light scattering (DLS), environmental scanning electron microscopy (ESEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and X-ray diffraction (XRD)...
December 12, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29227481/nafion-particles-doped-with-methyl-viologen-electrochemistry
#12
Haiying Yang, Xiuting Li, Christopher Batchelor-McAuley, Stanislav V Sokolov, Richard G Compton
Nafion sub-micro particles doped with methyl viologen (MV2+) are synthesized using the re-precipitation method and characterized by scanning electron microscopy and UV-Vis spectroscopy. The electrochemical behavior of MV2+ incorporated into Nafion particles was investigated at both the ensemble and single particle levels. The charge transferred to single MV-Nafion particles was observed using the nano-impact method and shown to be quantitative. Finally, the charge transferred via individual MV-Nafion particle was substantially enhanced in the presence of permanganate...
December 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29226729/formulation-of-sitagliptin-loaded-oral-polymeric-nano-scaffold-process-parameters-evaluation-and-enhanced-anti-diabetic-performance
#13
Mohammed Asadullah Jahangir, Ruqaiyah Khan, Syed Sarim Imam
PURPOSE: The aim of the study to formulate and statistically optimize sitagliptin-loaded eudragit nanoparticles (SIT-NPs) and evaluate the in-vitro pharmaceutical quality and in-vivo anti-diabetic assessment. METHOD: SIT-NPs were prepared by using combination method of solvent evaporation and nano-precipitation techniques. The influence of different independent variables as eudragit RL100 concentration (%), tween 80 concentration (%) and sonication time (min) were evaluated on dependent variables like particle size (nm), drug loading (%) and in-vitro drug release (%)...
December 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29226470/photo-crosslinkable-unnatural-amino-acids-enable-facile-synthesis-of-thermoresponsive-nano-to-microgels-of-intrinsically-disordered-polypeptides
#14
Simone A Costa, Joseph R Simon, Miriam Amiram, Lei Tang, Stefan Zauscher, Eric M Brustad, Farren J Isaacs, Ashutosh Chilkoti
Hydrogel particles are versatile materials that provide exquisite, tunable control over the sequestration and delivery of materials in pharmaceutics, tissue engineering, and photonics. The favorable properties of hydrogel particles depend largely on their size, and particles ranging from nanometers to micrometers are used in different applications. Previous studies have only successfully fabricated these particles in one specific size regime and required a variety of materials and fabrication methods. A simple yet powerful system is developed to easily tune the size of polypeptide-based, thermoresponsive hydrogel particles, from the nano- to microscale, using a single starting material...
December 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29226269/evaluating-weathering-of-food-packaging-polyethylene-nano-clay-composites-release-of-nanoparticles-and-their-impacts
#15
Changseok Han, Amy Zhao, Eunice Varughese, E Sahle-Demessie
Nano-fillers are increasingly incorporated into polymeric materials to improve the mechanical, barrier or other matrix properties of nanocomposites used for consumer and industrial applications. However, over the life cycle, these nanocomposites could degrade due to exposure to environmental conditions, resulting in the release of embedded nanomaterials from the polymer matrix into the environment. This paper presents a rigorous study on the degradation and the release of nanomaterials from food packaging composites...
January 1, 2018: NanoImpact
https://www.readbyqxmd.com/read/29224346/speciation-of-mercury-in-selected-areas-of-the-petroleum-value-chain
#16
Astrid Avellan, John Stegemeier, Ke Gai, James G Dale, Heileen Hsu-Kim, Clément Levard, Dennis O'Rear, Thomas P Hoelen, Gregory V Lowry
Petroleum, natural gas, and natural gas condensate can contain low levels of mercury (Hg). The speciation of Hg can affect its behavior during processing, transport, and storage so efficient and safe management of Hg requires an understanding of its chemical form in oil, gas and byproducts. Here, X-ray absorption spectroscopy was used to determine the Hg speciation in samples of solid residues collected throughout the petroleum value chain including stabilized crude oil residues, sediments from separation tanks and condensate glycol dehydrators, distillation column pipe scale, and biosludge from wastewater treatment...
December 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29223654/formulation-physical-in%C3%A2-vitro-and-ex%C3%A2-vivo-evaluation-of-nanomedicine-based-chemosterilant-for-non-surgical-castration-of-male-animals
#17
Sasithon Pagseesing, Jakarwan Yostawonkul, Suvimol Surassmo, Suwimon Boonrungsiman, Katawut Namdee, Mattaka Khongkow, Chatwalee Boonthum, Tawin Iempridee, Uracha Rungsardthong Ruktanonchai, Nattika Saengkrit, Kaywalee Chatdarong, Suppawiwat Ponglowhapan, Teerapong Yata
The overpopulation of free-roaming companion animals has become the global crisis. The development and application of a suitable, effective, non-surgical approach for animal sterilization would have an enormous advantage over the current surgical method. The main purpose of this study was to develop and evaluate a novel nanomedicine-based chemosterilant for non-surgical castration of male companion animals. In this study, we first sought to investigate the testicular toxicity of different apoptosis-inducing agents...
December 5, 2017: Theriogenology
https://www.readbyqxmd.com/read/29223573/biocompatibility-of-designed-micno-zno-particles-cytotoxicity-genotoxicity-and-phototoxicity-in-human-skin-keratinocyte-cells
#18
Hatice Genç, Banu Barutca, A Tansu Koparal, Uğurcan Özöğüt, Yücel Şahin, Ender Suvacı
Recently, designed platelet shaped micron particles that are composed of nano primary particles, called MicNo (=Micron+naNo) particles, have been developed to exploit the benefits of nano size, while removing the adverse effects of nanoparticles. It has been shown that MicNo-ZnO particles exhibit both micron and nanosized particle characteristics. Although physical and chemical properties of MicNo-ZnO particles have been studied, their biocompatibility has not yet been evaluated. Accordingly, the research objective of this study was to evaluate in vitro cytotoxicity, genotoxicity and phototoxicity behaviors of designed MicNo-ZnO particles over human epidermal keratinocyte (HaCaT) cells...
December 6, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29222980/bonding-of-doxorubicin-to-nanosilica-and-human-serum-albumin-in-various-media
#19
V M Gun'ko, T V Krupska, L S Andriyko, N Yu Klymenko, I V Siora, O A Novikova, A I Marynin, A I Ukrainets, B Charmas, S B Shekhunova, V V Turov
Interaction of doxorubicin hydrochloride (DOX) (anti-cancer drug) with hydro-compacted nanosilica A-300 (cA-300) alone or cA-300/human serum albumin (HSA) at a small content of water (h = 0.4 g per gram of dry silica) in different dispersion media (air, chloroform, and chloroform/trifluoroacetic acid) was analyzed using low-temperature 1H NMR spectroscopy, NMR cryoporometry and quantum chemistry to elucidate specific changes in the interfacial layers. Initial (bulk density ρb ≈ 0.046 g/cm3) and hydro-compacted (ρb ≈ 0...
December 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29220865/silver-nano-particles-ameliorate-learning-and-spatial-memory-of-male-wistar-rats-by-prevention-of-amyloid-fibril-induced-neurotoxicity
#20
H Ramshini, A-S Moghaddasi, L-S Aldaghi, N Mollania, A Ebrahim-Habibi
Alzheimer's disease (AD) is a chronic degenerative disease characterized by the presence of amyloid plaques and neurofibrillary tangles (NFTs), which results into memory and learning impairments. In the present study, we showed that the aggregates formed by a protein that has no link with Alzheimer's disease, namely the hen egg white lysozyme (HEWL), were cytotoxic and decreased spatial learning and memory in rats. The effect of Ag-nano particles (Ag-NPs) was investigated on disruption of amyloid aggregation and preservation of cognitive behavior of rats...
December 8, 2017: Archives Italiennes de Biologie
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