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Nano particle

Catherine A Fromen, William J Kelley, Margaret B Fish, Reheman Adili, Jeffery Noble, Mark J Hoenerhoff, Michael Holinstat, Omolola Eniola-Adefeso
Although nano- and microparticle therapeutics have been studied for a range of drug delivery applications, the presence of these particles in blood flow may have considerable and understudied consequences to circulating leukocytes, especially neutrophils, which are the largest human leukocyte population. The objective of this work was to establish if particulate drug carriers in circulation interfere with normal neutrophil adhesion and migration. Circulating blood neutrophils in vivo were found to be capable of rapidly binding and sequestering injected carboxylate-modified particles of both 2 µm and 0...
October 13, 2017: ACS Nano
Jian Yang, Chuangui Liu, Boqian Wang, Xianting Ding
Superhydrophobic surface, as a promising micro/nano material, has tremendous applications in biological and artificial investigations. The electrohydrodynamics (EHD) technique is a versatile and effective method for fabricating micro- to nanoscale fibers and particles from a variety of materials. A combination of critical parameters, such as mass fraction, ratio of N, N-Dimethylformamide (DMF) to Tetrahydrofuran (THF), inner diameter of needle, feed rate, receiving distance, applied voltage as well as temperature, during electrospinning process, to determine the morphology of the electrospun membranes, which in turn determines the superhydrophobic property of the membrane...
October 13, 2017: Nanomaterials
Zhimin Chai, Cihan Yilmaz, Ahmed Busnaina, Charles A Lissandrello, David J D Carter
Printing nano and microscale three-dimensional (3D) structures using directed assembly of nanoparticles has many potential applications in electronics, photonics and biotechnology. This paper presents a reproducible and scalable 3D dielectrophoresis assembly process for printing homogeneous silica and hybrid silica/gold nanorods from silica and gold nanoparticles. The nanoparticles are assembled into patterned vias under a dielectrophoretic force generated by an alternating current (AC) field, and then completely fused in situ to form nanorods...
October 13, 2017: Nanotechnology
Inha Jung, Eun-Jeong Joo, Byung Seong Suh, Cheol-Bae Ham, Ji-Min Han, You-Gyung Kim, Joon-Sup Yeom, Ju-Yeon Choi, Ji-Hye Park
BACKGROUND: Argyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble silver-nano particles and presented with muscle weakness. CASE PRESENTATION: A 74-year-old woman visited our emergency room, complaining of fever and mental deterioration. She was diagnosed with acute pyelonephritis and recovered after antibiotic therapy...
2017: Annals of Occupational and Environmental Medicine
Yan Ru Wu, Hong Jin Choi, Yun Gyeong Kang, Jeong Koo Kim, Jung-Woog Shin
PURPOSE: This study aimed to develop an anti-inflammation system consisting of epigallo-catechin-3-gallate (EGCG) encapsulated in poly(lactide-co-glycolic acid) (PLGA) particles to promote wound healing. METHODS: Nano- and microscale PLGA particles were fabricated using a water/oil/water emulsion solvent evaporation method. The optimal particle size was determined based on drug delivery efficiency and biocompatibility. The particles were loaded with EGCG. The anti-inflammatory effects of the particles were evaluated in an in vitro cell-based inflammation model...
2017: International Journal of Nanomedicine
Raman Dhivya, Jothi Ranjani, Jeyaprakash Rajendhran, Jeyanthinath Mayandi, Jamespandi Annaraj
Curcumin loaded ZnO nanoparticles were successfully synthesised and encapsulated with co-polymer PMMA-AA (Cur/PMMA-AA/ZnO NPs). The ZnO nanoparticles have been converted as good cargo materials to carry the well-known hydrophobic drug curcumin by surface functionalization. Physical characteristics of these novel nanomaterials have been studied with transmission electron microscopy (TEM) and powder X-ray diffraction (XRD) in conjunction with spectral techniques. A narrow particle size distribution with an average value of 42nm was found via TEM...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Vinicius B V Maciel, Cristiana M P Yoshida, Susana M S S Pereira, Francisco M Goycoolea, Telma T Franco
A polyelectrolyte complex system of chitosan-pectin nano- and microparticles was developed to encapsulate the hormone insulin. The aim of this work was to obtain small particles for oral insulin delivery without chemical crosslinkers based on natural and biodegradable polysaccharides. The nano- and microparticles were developed using chitosans (with different degrees of acetylation: 15.0% and 28.8%) and pectin solutions at various charge ratios (n⁺/n(-) given by the chitosan/pectin mass ratio) and total charge...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Swati Shikha, Thoriq Salafi, Jinting Cheng, Yong Zhang
Encoded nano-structures/particles have been used for barcoding and are in great demand for the simultaneous analysis of multiple targets. Due to their nanoscale dimension(s), nano-barcodes have been implemented favourably for bioimaging, in addition to their security and multiplex bioassay application. In designing nano-barcodes for a specific application, encoding techniques, synthesis strategies, and decoding techniques need to be considered. The encoding techniques to generate unique multiple codes for nano-barcodes are based on certain encoding elements including optical (fluorescent and non-fluorescent), graphical, magnetic, and phase change properties of nanoparticles or their different shapes and sizes...
October 12, 2017: Chemical Society Reviews
Brian M Dincau, Yongkuk Lee, Jong-Hoon Kim, Woon-Hong Yeo
Early disease diagnostics require rapid, sensitive, and selective detection methods for target analytes. Specifically, early viral detection in a point-of-care setting is critical in preventing epidemics and the spread of disease. However, conventional methods such as enzyme-linked immunosorbent assays or cell cultures are cumbersome and difficult for field use due to the requirements of extensive lab equipment and highly trained personnel, as well as limited sensitivity. Recent advances in nanoparticle concentration have given rise to many novel detection methodologies, which address the shortcomings in modern clinical assays...
October 11, 2017: Sensors
Hidekazu Ikeno, Teruyasu Mizoguchi
The electron energy loss near edge structures (ELNES) appearing in an electron energy loss spectrum obtained through transmission electron microscopy (TEM) have the potential to unravel atomic and electronic structures with sub-nano meter resolution. For this reason, TEM-ELNES has become one of the most powerful analytical methods in materials research. On the other hand, theoretical calculations are indispensable in interpreting the ELNES spectrum. Here, the basics and applications of one-particle, two-particle and multi-particle ELNES calculations are reviewed...
October 1, 2017: Microscopy
Yuriy K Bashmakov, Ivan M Petyaev
Dendrimers are unimolecular architectural nano- or microparticle entities that can accommodate various nutraceuticals and pharmaceuticals between their branches (dendrons) and provide targeted delivery of biomimetics into different tissues upon addition of functionalized groups to the dendrimer's surface. Covalent binding, hydrogen bonds, and electrostatic interactions between dendrimer-composing molecules are known to form and stabilize dendrimer structure. Carotenoids have recently been shown to form dendrimer-like structures and promote targeted delivery of "cargo" molecules into organs characterized by high-carotenoid uptake (adrenal glands, prostate, liver, and brain)...
October 10, 2017: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
Nyha Hameed, Ali Nouho Ali, Fadi I Baida
In this paper, we propose and numerically simulate a novel optical trapping process based on the enhancement and the confinement of both magnetic and electric near-fields by using gold Diabolo Antenna (DA). The later was recently proposed to generate huge magnetic near-field when illuminated by linearly polarized wave along its axis. Numerical 3D - FDTD simulation results demonstrate the high confinement of the electromagnetic field in the vicinity of the DA. This enhancement is then exploited for the trapping of nano-particles (NP) as small as 30 nm radius...
October 9, 2017: Scientific Reports
Shashwati Sen, Mohit Tyagi, Kusha Sharma, Partha Sarathi Sarkar, Sudip Sarkar, Chandra Bhanu Basak, Shreyas Pitale, Manoranjan Ghosh, Sanjay C Gadkari
Organic-Inorganic nanocomposite films of Gd3Ga3Al2O12:Ce (GGAG) scintillator uniformly dispersed in PMMA and PS polymer are prepared for X-ray imaging applications. Inorganic GGAG nano-scintillator has been chosen because of its high light output and fast decay time. The nano powder of GGAG with grain size 100 nm is synthesized by co-precipitation method and dispersed in the PMMA and PS polymer matrix by a simple blending technique. The nanocomposite films thus formed are self-standing in nature with thickness in the range of 150-450 micron and having a very high percentage of inorganic content...
October 9, 2017: ACS Applied Materials & Interfaces
Jalal Mosayebi, Mehdi Kiyasatfar, Sophie Laurent
In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non-invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section...
October 9, 2017: Advanced Healthcare Materials
Ragesh Kumar T P, Ragnar Bjornsson, Sven Barth, Oddur Ingólfsson
In single electron collisions with the heteronuclear metal carbonyl compound HFeCo3(CO)12 we observe the formation of long-lived negative ion states up to about 20 eV, 11 eV above its ionization energy. These transient negative ions (TNIs) relax through dissociation (dissociative electron attachment, DEA), losing up to all 12 CO ligands, demonstrating their resilience towards reemission of the captured electron - even at such very high energies. This is unique in DEA and we hypothesize that this phenomenon is rooted in the orbital structure enabling a scaffold of multi-particle, electronically excited resonances...
September 1, 2017: Chemical Science
Noriaki Nagai, Fumihiko Ogata, Hiroko Otake, Naohito Kawasaki, Yosuke Nakazawa, Kazutaka Kanai, Norio Okamoto, Yoshikazu Shimomura
We prepared magnesium hydroxide (MH) nanoparticles by a bead mill method, and investigated whether the co-instillation of MH nanoparticles improves the low transcorneal penetration of water-soluble drugs, such as the anti-glaucoma eye drug timolol maleate (TM). MH particle size was decreased by the bead mill treatment to a mean particle size of 71 nm. In addition, the MH nanoparticles were highly stable. Next, we demonstrated the effect of MH nanoparticles on the corneal surface. MH shows only slight solubility in lacrimal fluid, and the instillation of MH nanoparticles for 14 days did not affect the behavior (balance of secretion and excretion) of the lacrimal fluid in rabbit corneas...
October 5, 2017: Experimental Eye Research
J Shim, D S Stewart, A D Nikolov, D T Wasan, R Wang, R Yan, Y C Shieh
Enteric viruses are recognized as a major etiology for U.S. foodborne infections. These viruses are easily transmitted via food contact surfaces. Understanding virus interactions with surfaces may facilitate developing improved means for their removal thus reducing transmission. Using MS2 coliphage as a virus surrogate, the strength of virus adhesion onto common food processing and preparation surfaces of polyvinyl chloride (PVC) and glass were assessed by atomic force microscopy (AFM) and virus recovery assays...
October 6, 2017: Applied and Environmental Microbiology
Louise M Stevenson, Adeyemi S Adeleye, Yiming Su, Yalei Zhang, Arturo A Keller, Roger M Nisbet
Nanozerovalent iron (nZVI) is widely used for its ability to remove or degrade environmental contaminants. However, the effect of nZVI-pollutant complexes on organisms has not been tested. We demonstrate the ability of a sulfidized derivative of nZVI (FeSSi) to sorb cadmium (Cd) from aqueous media and alleviate Cd toxicity to a freshwater alga for 32 days. FeSSi particles removed over 80% of the aqueous Cd in the first hour and nearly the same concentration of free Cd remained unbound at the end of the experiment...
October 11, 2017: ACS Nano
Sungeun Ahn, Priyanka Singh, Mi Jang, Yu-Jin Kim, Verónica Castro-Aceituno, Shakina Yesmin Simu, Yeon Ju Kim, Deok-Chun Yang
We reported the rapid synthesis (<8s) of gold nanoparticles at room temperature using Acanthopanacis cortex extract (A-AuNPs). We characterized the A-AuNPs using several analytical techniques and found that nano-flower type A-AuNPs, which are known to possess a coarse surface with a high surface to volume ratio, conferring these particles with high binding capacity for various biological molecules. After confirming the stability of the nanoparticles, we investigated the anti-inflammatory effect of A-AuNPs in LPS-stimulated RAW264...
September 25, 2017: Colloids and Surfaces. B, Biointerfaces
Yawei Gu, Binbin Wang, Feng He, Miranda J Bradley, Paul G Tratnyek
In water treatment processes that involve contaminant reduction by zero-valent iron (ZVI), reduction of water to dihydrogen is a competing reaction that must be minimized to maximize the efficiency of electron utilization from the ZVI. Sulfidation has recently been shown to decrease H2 formation significantly, such that the overall electron efficiency of (or selectivity for) contaminant reduction can be greatly increased. To date, this work has focused on nano-scale ZVI (nZVI) and solution-phase sulfidation agents (e...
October 6, 2017: Environmental Science & Technology
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