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Nano particle

Lijuan Jiang, Xin Liang, Gan Liu, Yun Zhou, Xinyu Ye, Xiuli Chen, Qianwei Miao, Li Gao, Xudong Zhang, Lin Mei
Protein nanocapsules have exhibited promising potential applications in the field of protein drug delivery. A major issue with various promising nano-sized biotherapeutics including protein nanocapsules is that owing to their particle size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. In addition, many nano-sized biotherapeutics could be also sequestered by autophagosomes and degraded through the autolysosomal pathway...
November 2018: Drug Delivery
Xinghao Hu, Sri Ramulu Torati, Jonghwan Yoon, Byeonghwa Lim, Kunwoo Kim, CheolGi Kim
We demonstrate an efficient approach for quantifying frictional forces (sub-pN) at nano-bio interfaces by controlled magnetic forces, which is based on simultaneous measurements of critical frequencies for streptavidin-coupled magnetic particles. The maximum phase angle, being corresponded with the critical frequency, is formulated in terms of magnetic, frictional and viscous forces of the particles on DNA and SiO2 functionalized micromagnet arrays. The streptavidin/DNA interface shows lower friction as an enhanced lubrication than the streptavidin/SiO2 interface, which is indicated by the lower transition field of quasi-static motion, the larger ratio of dynamic particles, and also the higher velocity of the particles...
April 18, 2018: ACS Applied Materials & Interfaces
Emilia Victoria Silletta, Zhe Xu, Mena Youssef, Stefano Sacanna, Alexej Jerschow
The controlled shaping and surface functionalization of colloidal particles has provided opportunities for the development of new materials and responsive particles. The possibility of creating hollow particles with semi-permeable walls allows modulating molecular transport properties on colloidal length scales. While shapes and sizes can typically be observed by optical means, the underlying chemical and physical properties are often invisible. Here, we present measurements of cross-membrane transport via pulsed field gradient NMR in packings of hollow colloidal particles...
April 17, 2018: Journal of Physical Chemistry. B
Nako Nakatsuka, Mohammad Mahdi Hasani-Sadrabadi, Kevin M Cheung, Thomas D Young, Ghasem Bahlakeh, Alireza Moshaverinia, Paul S Weiss, Anne M Andrews
Serotonin-based nanoparticles represent a class of previously unexplored multifunctional nanoplatforms with potential biomedical applications. Serotonin, under basic conditions, self-assembles into monodisperse nanoparticles via autoxidation of serotonin monomers. To demonstrate potential applications of polyserotonin nanoparticles for cancer therapeutics, we show that these particles are biocompatible, exhibit photothermal effects when exposed to near-infrared radiation, and load the chemotherapeutic drug doxorubicin releasing it contextually and responsively in specific microenvironments...
April 17, 2018: ACS Nano
Saeed Zahiri, Elahe Masaeli, Elahe Poorazizi, Mohammad Hossein Nasr-Esfahani
Current studies based on regenerative medicine suggest, decellularized extracellular matrix (DC-ECM) components can regulate cell phenotype. In this regard, it is believed, presence of cartilage extracellular matrix particles in culture condition could produce physical and biochemical supportive cues for chondrogenesis. In this study, DC-ECM nanoparticles with average size of 61.5± 22.4 nm were produced by decellularization and mechanical processing. Homogenous distribution and nano scale size of yield particles were observed by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) microscopy imaging...
April 17, 2018: Journal of Biomedical Materials Research. Part A
Liming Xu, Ru Bai, Xiang Cheng, Anliang Shao, Liang Chen, Shuxin Qu, Chunying Chen
Silver-containing dressings are widely used for wound care owing to their broad-spectrum microbicidal activity. However, the potential adverse effects on human health emerging from exposure to their active ingredients (silver ions or nanoparticles) have resulted in widespread concerns about their use. The release profiles of various chemical forms of silver (Ag) from silver-containing dressing are closely related to their bioavailability and potential adverse effects on the body. In this research, we demonstrated a tiered experimental approach for systematic characterization and assessment of silver-containing wound dressing, which provides information for risk assessments...
March 1, 2018: Journal of Biomedical Nanotechnology
Halla Laufey Hauksdóttir, Thomas J Webster
Iron oxide nanoparticles (IONP) are already well-established in the medical field due to their ability to improve contrast in magnetic resonance imaging (MRI) and for their external magnetic control in the body. Moreover, selenium has been shown to kill numerous cancer cells at lower concentrations that IONP (e.g., 1 μg/ml). Selenium is a trace mineral of growing interest in cancer treatment since it is an essential nutrient in the human body and can interfere with thiolcontaining proteins necessary for cancer cells to function...
March 1, 2018: Journal of Biomedical Nanotechnology
Jianhong Liao, Haoran Zheng, Rui Hu, Jun Cao, Xuan Wei, Dan Li, Hua Zheng, Yihua Yin
In this study, a series of amphiphilic polymeric prodrugs (Azido-functionalized hyaluronan-triazole-imine-doxorubicin, HAimine-DOX) were designed and synthesized by the "Click" reaction with a remarkable grafting ratio of DOX. Nanoparticles with a core-shell structure can be obtained by self-assembling in aqueous media, which exhibited a particle size of 137-170 nm. Moreover, the HA-imine-DOX nanoparticles exhibited good stability in vitro, and the drug release was obviously mediated by the pH gradient...
March 1, 2018: Journal of Biomedical Nanotechnology
Alina M Crainic, Mauro Callisti, Martin R Palmer, Richard B Cook
The in vivo release of wear debris and corrosion products from the metallic interfaces of total hip replacements is associated with a wide spectrum of adverse body reactions and systemic manifestations. The origin of debris and the electrochemical conditions at the sites of material loss both play a role in determining the physicochemical characteristics of the particles, and thus influence their in vivo reactivity. Debris retrieved from revised CoCrMo tapers and cement-stem interfaces consists of heterogeneous flakes that comprise mechanically mixed metal particles, corrosion products and organic material...
April 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Alireza Eivazihollagh, Magnus Norgren, Christina Dahlström, Håkan Edlund
In this study, Cu and Cu₂O nanoparticles (NPs) were synthesized through chemical reduction of soluble copper-chelating ligand complexes using formaldehyde as a reducing agent. The influence of various chelating ligands, such as ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), and a surface-active derivative of DTPA (C12 -DTPA), as well as surfactants (i.e., hexadecyltrimethylammonium bromide (CTAB), dodecyltrimethylammonium chloride (DoTAC), sodium dodecyl sulfate (SDS), and dimethyldodecylamine-N-oxide (DDAO)), on morphology and the composition of produced NPs was investigated...
April 14, 2018: Nanomaterials
Hairul Abral, Vincent Lawrensius, Dian Handayani, Eni Sugiarti
As more applications for nano-sized natural particles are discovered, simple, environmentally friendly ways to produce these particles become more important. This work prepares and characterizes nano-size bacterial cellulose particles using ultrasonication. Pellicle from nata de coco containing nanofibers was broken up in an electrical blender, then sonicated using an ultrasonic probe at 20 kHz and 3 W/mL for 30, 60 and 90 min. Transmission electron microscope observations indicate the particles become nano-sized after 60 min ultrasound...
July 1, 2018: Carbohydrate Polymers
Renze Shen, Weihong Xu, Yanxiang Xue, Luyuan Chen, Haicheng Ye, Enyi Zhong, Zhanchao Ye, Jie Gao, Yurong Yan
OBJECTIVE: In this study, nanofibrous scaffolds base on pure polylactic acid (PLA) and chitosan/PLA blends were fabricated by emulsion eletrospinning. By modulating their mechanical and biological properties, cell-compatible and biodegradable scaffolds were developed for periodontal bone regeneration. METHODS: Pure PLA and different weight ratios of chitosan nano-particle/PLA nano-fibers were fabricated by emulsion eletrospinning. Scanning electron microscope (SEM) was performed to observe the morphology of nano-fibers...
April 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Janja Vidmar, Primož Oprčkal, Radmila Milačič, Ana Mladenovič, Janez Ščančar
Zero-valent iron nanoparticles (nZVI) exhibit great potential for the removal of metal contaminants from wastewater. After their use, there is a risk that nZVI will remain dispersed in remediated water and represent potential nano-threats to the environment. Therefore, the behaviour of nZVI after remediation must be explored. To accomplish this, we optimised a novel method using single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) for the sizing and quantification of nZVI in wastewater matrices...
April 12, 2018: Science of the Total Environment
Lijun T Raju, Shubhankar Chakraborty, Binita Pathak, Saptarshi Basu
Spatially varying ordering of colloids of multiple sizes at micro-nano scales finds application in different industrial processes including manufacturing of photonic crystals. In this work, we showcase a unique physics based architecture through which we have been able to control the morphology of the precipitates evolving out of the drying of a contact free droplet at micro to nano length-scales. We show that by varying the relative concentration of the larger sized colloids, one can modulate evaporation, subsequent particle transport and particle ordering at the droplet interface, thereby controlling the rates of certain instabilities like buckling...
April 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Rania E Morsi, Rasha S Mohamed
A series of ordered mesoporous silica such as MCM-41, SBA-3 and SBA-15, in addition to silica micro- (SM) and nano- (SN) mesoporous particles, were prepared. The preparation conditions were found to greatly influence the physical-surface properties including morphological structure, porosity, particle size, aggregate average size, surface area, pore size, pore volume and zeta potential of the prepared silica, while the chemical structure, predicted from FT-IR spectra, and the diffraction patterns, predicted from wide-angle X-ray diffraction spectra, were identical...
March 2018: Royal Society Open Science
Haitao Li, Na Li, Ming Wang, Beiping Zhao, Fei Long
Graphitic carbon nitride (g-C3 N4 ) nanosheets with a thickness of only a few nanometres were obtained by a facile deammoniation treatment of bulk g-C3 N4 and were further hybridized with Bi2 WO6 nanoparticles on the surface via a solvothermal method. The composite photocatalysts were characterized by powder X-ray diffraction, scanning electron microscopy, transmission electron microscopy, UV-vis diffuse reflection spectroscopy and X-ray photoelectron spectroscopy (XPS). The HR-TEM results show that the nano-sized Bi2 WO6 particles were finely distributed on g-C3 N4 sheet surface, which forms heterojunction structure...
March 2018: Royal Society Open Science
Edyta Swider, Olga Koshkina, Jurjen Tel, Luis J Cruz, I Jolanda M de Vries, Mangala Srinivas
Nano- and microparticles have increasingly widespread applications in nanomedicine, ranging from drug delivery to imaging. Poly(lactic-co-glycolic acid) (PLGA) particles are the most widely-applied type of particles due to their biocompatibility and biodegradability. Here, we discuss the preparation of PLGA particles, and various modifications to tailor particles for applications in biological systems. We highlight new preparation approaches, including microfluidics and PRINT method, and modifications of PLGA particles resulting in novel or responsive properties, such as Janus or upconversion particles...
April 10, 2018: Acta Biomaterialia
Chaoyou Tao, Xinshu Zou, Kai Du, Lin Zhang, Hongwei Yan, Xiaodong Yuan
Shape-tunable hollow silica nanomaterials, including hollow silica nano-spheres and nano-tadpoles, were synthesized with a one-step soft-templating method. A possible particle growth mechanism was proposed. Films were built from these shape-tunable hollow silica nanomaterials with refractive indices as low as 1.045, which is, to the best of our knowledge, the third-lowest value ever reported so far. For the first time, the refractive indices of films were tuned by changing the morphology of building blocks...
April 15, 2018: Optics Letters
Xinfeng Du, Liyuan Yang, Wenchang Hu, Renjie Wang, Jingying Zhai, Xiaojiang Xie
Nanoscale ionophore-based ion-selective optodes (nano-ISOs) are effective sensing tools for in situ and real time measurements of ion concentrations in biological and environmental samples. While searching for novel sensing materials, nano-ISOs free of plasticizers are particularly important for biological and environmental applications. This work described plasticizer-free nano-ISOs based on Si-containing particles including PEGylated organosilica nanoparticle, PDMS nanospheres and SiO2 microspheres, with diameters around 50 nm, 100 nm, and 5 μm, respectively...
April 13, 2018: Analytical Chemistry
C Frieke Kuper, Jolanda van Bilsen, Marcel V W Wijnands
The thoracic cavities receive increasing attention in toxicology, because inhaled fibers and (nano)particles can reach these cavities and challenge the local lymphoid tissues. The thoracic and abdominopelvic cavities are controlled by the serosal immune system with its special, loosely organized lymphoid clusters, namely the fat-associated lymphoid clusters (FALCs) and milky spots, which together can be denoted as serosa-associated lymphoid clusters (SALCs). These clusters house numerous innate lymphoid cells, namely the B1 and ILC2 populations...
April 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
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