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https://www.readbyqxmd.com/read/28527406/the-relevance-of-ki-calculation-for-bi-substrate-enzymes-illustrated-by-kinetic-evaluation-of-a-novel-lysine-k-acetyltransferase-8-inhibitor
#1
Hannah Wapenaar, Thea van den Bosch, Niek G J Leus, Petra E van der Wouden, Nikolaos Eleftheriadis, Jos Hermans, Gebremedhin Solomon Hailu, Dante Rotili, Antonello Mai, Alexander Dömling, Rainer Bischoff, Hidde J Haisma, Frank J Dekker
Histone acetyltransferases (HATs) are important mediators of epigenetic post-translational modifications of histones that play important roles in health and disease. A disturbance of these modifications can result in disease states, such as cancer or inflammatory diseases. Inhibitors of HATs (HATi) such as lysine (K) acetyltransferase 8 (KAT8), could be used to study the epigenetic processes in diseases related to these enzymes or to investigate HATs as therapeutic targets. However, the development of HATi is challenged by the difficulties in kinetic characterization of HAT enzymes and their inhibitors to enable calculation of a reproducible inhibitory potency...
May 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28526997/nafld-as-a-sexual-dimorphic-disease-role-of-gender-and-reproductive-status-in-the-development-and-progression-of-nonalcoholic-fatty-liver-disease-and-inherent-cardiovascular-risk
#2
REVIEW
Stefano Ballestri, Fabio Nascimbeni, Enrica Baldelli, Alessandra Marrazzo, Dante Romagnoli, Amedeo Lonardo
Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatis, cirrhosis, and hepatocellular carcinoma (HCC) associated with striking systemic features and excess cardiovascular and liver-related mortality. The pathogenesis of NAFLD is complex and multifactorial. Endocrine derangements are closely linked with dysmetabolic traits. For example, in animal and human studies, female sex is protected from dysmetabolism thanks to young individuals' ability to partition fatty acids towards ketone body production rather than very low density lipoprotein (VLDL)-triacylglycerol, and to sex-specific browning of white adipose tissue...
May 19, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28523329/respiratory-bronchiolitis-associated-interstitial-lung-disease-an-unexpected-form-of-idiopathic-interstitial-pneumonia-in-a-young-male
#3
Claudia Lucia Toma, Elena Danteş, Diana Gabriela Leonte, Ariadna Petronela Fildan
Cigarette smoking is the most frequently encountered risk factor for chronic obstructive pulmonary disease and lung cancer. The latest American Thoracic Society÷European Respiratory Society classification of idiopathic interstitial pneumonia includes two entities related to smoking habits: respiratory bronchiolitis-associated interstitial lung disease and desquamative interstitial pneumonia. The new approach to diagnosis is to combine pathological pattern with clinical and radiological data. Lung biopsy is no longer considered the "gold standard" for diagnosis, but as a part of the diagnosis, which shall be set only after the pulmonologist, radiologist and pathologist reviewed all clinical, imaging and pathological aspects...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28513555/effect-of-low-dose-vitamin-d-supplementation-on-serum-25-oh-d-in-school-children-and-white-collar-workers
#4
Ronghua Zhang, Xiamusiye Muyiduli, Danting Su, Biao Zhou, Yueqiang Fang, Shuying Jiang, Shuojia Wang, Lichun Huang, Minjia Mo, Minchao Li, Bule Shao, Yunxian Yu
OBJECTIVE: Our study aimed to investigate the nutritional vitamin D status of school children aged 9-15 years and white-collar workers in Zhejiang province, and evaluate the efficacy of low-dose-oral vitamin D supplementation in both populations. METHODS: We conducted a prospective controlled trial during March 2014 to November 2015, comparing the efficacy of vitamin D supplements (400 IU/day) with non-intervention for 18 months in school children aged 9-15 years...
May 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28512324/global-gene-expression-analysis-provides-insight-into-local-adaptation-to-geothermal-streams-in-tadpoles-of-the-andean-toad-rhinella-spinulosa
#5
Luis Pastenes, Camilo Valdivieso, Alex Di Genova, Dante Travisany, Andrew Hart, Martín Montecino, Ariel Orellana, Mauricio Gonzalez, Rodrigo A Gutiérrez, Miguel L Allende, Alejandro Maass, Marco A Méndez
The anuran Rhinella spinulosa is distributed along the Andes Range at altitudes that undergo wide daily and seasonal variation in temperature. One of the populations inhabits geothermal streams, a stable environment that influences life history traits such as the timing of metamorphosis. To investigate whether this population has undergone local adaptation to this unique habitat, we carried out transcriptome analyses in animals from two localities in two developmental stages (prometamorphic and metamorphic) and exposed them to two temperatures (20 and 25 °C)...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28503895/quantitative-comparative-analysis-of-the-nasal-chemosensory-organs-of-anurans-during-larval-development-and-metamorphosis-highlights-the-relative-importance-of-chemosensory-subsystems-in-the-group
#6
Lucas David Jungblut, John O Reiss, Dante A Paz, Andrea G Pozzi
The anuran peripheral olfactory system is composed of a number of subsystems, represented by distinct neuroepithelia. These include the main olfactory epithelium and vomeronasal organ (found in most tetrapods) and three specialized epithelia of anurans: the buccal-exposed olfactory epithelium of larvae, and the olfactory recess and middle chamber epithelium of postmetamorphic animals. To better characterize the developmental changes in these subsystems across the life cycle, morphometric changes of the nasal chemosensory organs during larval development and metamorphosis were analyzed in three different anuran species (Rhinella arenarum, Hypsiboas pulchellus, and Xenopus laevis)...
May 14, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28500084/bisphenol-a-promotes-hepatic-lipid-deposition-involving-kupffer-cell-m1-polarization-in-male-mice
#7
Qiong Lv, Rufei Gao, Chuan Peng, Juan Yi, Lulu Liu, Shumin Yang, Danting Li, Jinbo Hu, Ting Luo, Mei Mei, Ying Song, Chaodong Wu, Xiaoqiu Xiao, Qifu Li
Bisphenol A (BPA), as one of the most common environmental endocrine disruptors, is considered to promote hepatic lipid deposition, but the mechanisms has not been fully elucidated. The polarization of Kupffer cells (KCs) plays an important role in hepatic inflammation by promoting pro-inflammatory M1 phenotype (M1KCs), which contributes to dysregulated lipid metabolism. The purpose of this study is to investigate the role of KC polarization in BPA-induced hepatosteatosis in male mice. In this study, we examined hepatic lipid contents and quantified M1KC in BPA-treated CD1 mice, and further explored the interaction between KCs and hepatocytes by using conditional HepG2 cell culture...
May 12, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28498540/patterns-of-adolescent-regulatory-responses-during-family-conflict-and-mental-health-trajectories
#8
Kalsea J Koss, E Mark Cummings, Patrick T Davies, Dante Cicchetti
Four distinct patterns of adolescents' behavioral, emotional, and physiological responses to family conflict were identified during mother-father-adolescent (M = 13.08 years) interactions. Most youth displayed adaptively regulated patterns comprised of low overt and subjective distress. Under-controlled adolescents exhibited elevated observable and subjective anger. Over-controlled adolescents were withdrawn and reported heightened subjective distress. Physiologically reactive adolescents had elevated cortisol coupled with low overt and subjective distress...
March 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28494347/structural-brain-abnormalities-in-patients-with-type-i-bipolar-disorder-and-suicidal-behavior
#9
Dante G G Duarte, Maila de Castro L Neves, Maicon R Albuquerque, Gustavo Turecki, Yang Ding, Fabio Luis de Souza-Duran, Geraldo Busatto, Humberto Correa
Some studies have identified brain morphological changes in the frontolimbic network (FLN) in bipolar subjects who attempt suicide (SA). The present study investigated neuroanatomical abnormalities in the FLN to find a possible neural signature for suicidal behavior in patients with bipolar disorder type I (BD-I). We used voxel-based morphometry to compare euthymic patients with BD-I who had attempted suicide (n=20), who had not attempted suicide (n=19) and healthy controls (HCs) (n=20). We also assessed the highest medical lethality of their previous SA...
May 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28493215/cervical-disc-replacement-surgery-indications-technique-and-technical-pearls
#10
REVIEW
Dante Leven, Joshua Meaike, Kris Radcliff, Sheeraz Qureshi
PURPOSE OF REVIEW: Cervical disc replacement (CDR) is a surgical option for appropriately indicated patients, and high success rates have been reported in the literature. Complications and failures are often associated with patient indications or technical variables, and the goal of this review is to assist surgeons in understanding these factors. RECENT FINDINGS: Several investigations have been published in the last 5 years supporting the use of CDR in specific patient populations...
May 10, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28492983/target-enrichment-sequencing-in-cultivated-peanut-arachis-hypogaea-l-using-probes-designed-from-transcript-sequences
#11
Ze Peng, Wen Fan, Liping Wang, Dev Paudel, Dante Leventini, Barry L Tillman, Jianping Wang
Enabled by the next generation sequencing, target enrichment sequencing (TES) is a powerful method to enrich genomic regions of interest and to identify sequence variations. The objective of this study was to explore the feasibility of probe design from transcript sequences for TES application in calling sequence variants in peanut, an important allotetraploid crop with a large genome size. In this study, we applied an in-solution hybridization method to enrich DNA sequences of seven peanut genotypes. Our results showed that it is feasible to apply TES with probes designed from transcript sequences in polyploid peanut...
May 10, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28487224/changes-in-intrinsic-functional-connectivity-and-group-relevant-salience-the-case-of-sport-rivalry
#12
Zargol Moradi, Dante Mantini, Alla Yankovskaya, Miles Hewstone, Glyn W Humphreys
Studies have shown that attending to salient group relevant information could increase the BOLD activity across distributed neural networks. However, it is unclear how attending to group relevant information changes the functional connectivity across these networks. We investigated this issue combining resting states and task-based fMRI experiment. The task involved football fans learning associations between arbitrary geometric shapes and the badges of in-group, the rival and the neutral football teams. Upon learning, participants viewed different badge/shape pairs and their task was to judge whether the viewed pair was a match or a mismatch...
May 6, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28481986/a-complex-thoracic-mass-mediastinal-arteriovenous-malformation
#13
Dante Luiz Escuissato, Gláucia Zanetti, Edson Marchiori
No abstract text is available yet for this article.
May 8, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28479116/assisted-vital-capacity-to-assess-recruitment-level-in-neuromuscular-diseases
#14
Dante B Santos, Aurélien Boré, Lorena Del Amo Castrillo, Matthieu Lacombe, Line Falaize, David Orlikowski, Frédéric Lofaso, Hélène Prigent
Respiratory muscle weakness and chest wall abnormalities in neuromuscular diseases (NMD) may lead to decreased pulmonary volumes. We assessed the reversibility of vital capacity (VC) reduction with mechanical In-Exsufflation (MI-E). We evaluated the effects of positive inspiratory and negative expiratory pressures on spirometric variables under passive (without patients' participation) and active (with active participation) application in 47 NMD patients. VC, inspiratory capacity (IC), expiratory reserve volume (ERV) were measured during maneuvers without and with MI-E assistance, delivering inspiratory assistance (+40cmH2O), expiratory assistance (-40cmH2O) and both (±40cmH2O)...
May 4, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28474702/-hemoglobin-changes-hb-in-miners-exposed-to-high-altitude-and-associated-factors
#15
Christian R Mejia, Dante M Quiñones-Laveriano, Raúl Gomero, Luis Pérez-Pérez
AIM: To determine the variation of hemoglobin (Hb) in two groups of miners working at different altitudes. METHODOLOGY: A longitudinal study conducted in a private company. Hb was obtained from entrance exams and annual checks of workers at two locations: at sea level and at Peruvian highlands (4,100 m), taken by trained staff and equipment calibrated to environmental conditions. We analyzed variations in the course of the years with the PA-GEE statistical test; p values were obtained...
March 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28474365/tackling-variability-a-multicenter-study-to-provide-a-gold-standard-network-approach-for-frontotemporal-dementia
#16
Lucas Sedeño, Olivier Piguet, Sofía Abrevaya, Horacio Desmaras, Indira García-Cordero, Sandra Baez, Laura Alethia de la Fuente, Pablo Reyes, Sicong Tu, Sebastian Moguilner, Nicolas Lori, Ramon Landin-Romero, Diana Matallana, Andrea Slachevsky, Teresa Torralva, Dante Chialvo, Fiona Kumfor, Adolfo M García, Facundo Manes, John R Hodges, Agustin Ibanez
Biomarkers represent a critical research area in neurodegeneration disease as they can contribute to studying potential disease-modifying agents, fostering timely therapeutic interventions, and alleviating associated financial costs. Functional connectivity (FC) analysis represents a promising approach to identify early biomarkers in specific diseases. Yet, virtually no study has tested whether potential FC biomarkers prove to be reliable and reproducible across different centers. As such, their implementation remains uncertain due to multiple sources of variability across studies: the numerous international centers capable conducting FC research vary in their scanning equipment and their samples' socio-cultural background, and, more troublingly still, no gold-standard method exists to analyze FC...
May 5, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28468568/impact-of-low-dose-ketamine-on-the-usage-of-continuous-opioid-infusion-for-the-treatment-of-pain-in-adult-mechanically-ventilated-patients-in-surgical-intensive-care-units
#17
Jessica L Buchheit, Daniel Dante Yeh, Matthias Eikermann, Hsin Lin
BACKGROUND: Ketamine at subanesthetic doses has been shown to provide analgesic effects without causing respiratory depression and may be a viable option in mechanically ventilated patients to assist with extubation. The aim of this study was to evaluate the effects of low-dose ketamine on opioid consumption in mechanically ventilated adult surgical intensive care unit (ICU) patients. METHODS: A retrospective review of mechanically ventilated adult patients receiving low-dose ketamine continuous infusion (1-5 µcg/kg/min) for adjunctive pain control admitted to surgical ICUs was conducted...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28463944/oral-mucosal-envenomation-of-an-infant-by-a-puss-caterpillar
#18
Dante Allen Pappano, Rebecca Trout Fryxell, Molly Warren
The term "puss caterpillar" describes the larva of at least two Megalopygidae species common to North America. Accidental contact with the hairs (setae) is intensely painful, and serious systemic effects have been reported. We describe the envenomation of an infant through the face and oral mucosa, resulting in severe discomfort, limited oral intake, and vomiting, but no other untoward effects.
May 1, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28463935/admission-n-terminal-pro-brain-natriuretic-peptide-nt-probnp-level-predicts-the-development-of-atrial-fibrillation-in-general-surgical-intensive-care-unit-patients
#19
Nalin Chokengarmwong, Daniel Dante Yeh, Yuchiao Chang, Luis Alfonso Ortiz, Haytham M A Kaafarani, Peter Fagenholz, David R King, Marc DeMoya, Kathryn Butler, Jarone Lee, George Velmahos, James Louis Januzzi, Elizabeth Lee-Lewandrowski, Kent Lewandrowski
BACKGROUND: New onset atrial fibrillation (AF) in critically ill surgical patients is associated with significant morbidity and increased mortality. N-terminal pro-B type natriuretic peptide (NT-proBNP) is released by cardiomyocytes in response to stress and may predict AF development after surgery. We hypothesized that elevated NT-proBNP level at surgical ICU admission predicts AF development in a general surgical and trauma population. METHODS: From July to October 2015, NT-proBNP concentrations were measured at ICU admission...
May 1, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28459200/study-of-the-tp53-codon-72-polymorphism-in-oral-cancer-and-oral-potentially-malignant-disorders-in-argentine-patients
#20
Ana Maria Zarate, Julieta Don, Dante Secchi, Andres Carrica, Fernanda Galindez Costa, Rene Panico, Martin Brusa, José Luis Barra, Mabel Brunotto
The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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