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https://www.readbyqxmd.com/read/29224229/power-doppler-ultrasound-assessment-of-vascularization-in-hidradenitis-suppurativa-lesions
#1
Raffaele Dante Caposiena Caro, Francesco Maria Solivetti, Luca Bianchi
BACKGROUND: Ultrasound and Power Doppler (PD) ultrasound are useful tools to study and monitor Hidradenitis Suppurativa (HS) patients. OBJECTIVE: Describe the Power Doppler signal of HS nodules, abscesses, fistulas. METHODS: A retrospective analysis of PD in mild, moderate, severe HS patients, collecting all demographic and clinical data. The lesions were classified according to their ultrasound morphology, describing the vascular degree - high, moderate, minimal - and distribution - peripheral, internal, mixed...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29211105/assessing-the-risk-zones-of-chagas-disease-in-chile-in-a-world-marked-by-global-climatic-change
#2
Valentina Tapia-Garay, Daniela P Figueroa, Ana Maldonado, Daniel Frías-Laserre, Christian R Gonzalez, Alonso Parra, Lucia Canals, Werner Apt, Sergio Alvarado, Dante Cáceres, Mauricio Canals
BACKGROUND: Vector transmission of Trypanosoma cruzi appears to be interrupted in Chile; however, data show increasing incidence of Chagas' disease, raising concerns that there may be a reemerging problem. OBJECTIVE: To estimate the actual risk in a changing world it is necessary to consider the historical vector distribution and correlate this distribution with the presence of cases and climate change. METHODS: Potential distribution models of Triatoma infestans and Chagas disease were performed using Maxent, a machine-learning method...
January 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29210983/the-potential-pathogenic-contributions-of-endothelial-barrier-and-arterial-contractile-dysfunction-to-shock-due-to-b-anthracis-lethal-and-edema-toxins
#3
REVIEW
Dante A Suffredini, Xizhong Cui, Wanying Xu, Yan Li, Peter Q Eichacker
Shock with B. anthracis infection is particularly resistant to conventional cardiovascular support and its mortality rate appears higher than with more common bacterial pathogens. As opposed to many bacteria that lack exotoxins directly depressing hemodynamic function, lethal and edema toxin (LT and ET respectively) both cause shock and likely contribute to the high lethality rate with B. anthracis. Selective inhibition of the toxins is protective in infection models, and administration of either toxin alone in animals produces hypotension with accompanying organ injury and lethality...
December 6, 2017: Toxins
https://www.readbyqxmd.com/read/29200425/correction-a-systematic-review-and-meta-analysis-of-preclinical-trials-testing-anti-toxin-therapies-for-b-anthracis-infection-a-need-for-more-robust-study-designs-and-results
#4
Wanying Xu, Lernik Ohanjanian, Junfeng Sun, Xizhong Cui, Dante Suffredini, Yan Li, Judith Welsh, Peter Q Eichacker
[This corrects the article DOI: 10.1371/journal.pone.0182879.].
2017: PloS One
https://www.readbyqxmd.com/read/29200082/pneumonitis-in-irradiated-lungs-after-nivolumab-a-brief-communication-and-review-of-the-literature
#5
Farkhad Manapov, Olarn Roengvoraphoj, Maurice Dantes, Sebastian Marschner, Minglun Li, Chukwuka Eze
Nivolumab is a feasible therapy option in patients with advanced non-small cell lung cancer (NSCLC) who progress on first-line treatment. However, there is limited information about an overlapping toxicity of PD-1 inhibitors when administered following thoracic radiotherapy (TRT). Three of 25 patients with advanced NSCLC were treated with palliative or curative intent. Nivolumab was initiated as second or third-line therapy after TRT for recurrent or progressive disease. All 3 patients developed grade 3 pneumonitis at some point during nivolumab therapy...
December 1, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29195555/feasibility-of-beta-particle-radioguided-surgery-for-a-variety-of-nuclear-medicine-radionuclides
#6
Carlo Mancini-Terracciano, Raffaella Donnarumma, Gaia Bencivenga, Valerio Bocci, Antonella Cartoni, Francesco Collamati, Ilaria Fratoddi, Alessandro Giordano, Luca Indovina, Daria Maccora, Michela Marafini, Riccardo Mirabelli, Silvio Morganti, Dante Rotili, Andrea Russomando, Teresa Scotognella, Elena Solfaroli Camillocci, Marco Toppi, Giacomo Traini, Iole Venditti, Riccardo Faccini
PURPOSE: Beta-particle radioguided tumor resection may potentially overcome the limitations of conventional gamma-ray guided surgery by eliminating, or at least minimizing, the confounding effect of counts contributed by activity in adjacent normal tissues. The current study evaluates the clinical feasibility of this approach for a variety of radionuclides. Nowadays, the only β- radioisotope suited to radioguided surgery is 90Y. Here, we study the β- probe prototype capability to different radionuclides chosen among those used in nuclear medicine...
November 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29178937/an-optimized-background-regimen-design-to-evaluate-the-contribution-of-levofloxacin-to-multidrug-resistant-tuberculosis-treatment-regimens-study-protocol-for-a-randomized-controlled-trial
#7
Tara C Bouton, Patrick P J Phillips, Carole D Mitnick, Charles A Peloquin, Kathleen Eisenach, Ramonde F Patientia, Leonid Lecca, Eduardo Gotuzzo, Neel R Gandhi, Donna Butler, Andreas H Diacon, Bruno Martel, Juan Santillan, Kathleen Robergeau Hunt, Dante Vargas, Florian von Groote-Bidlingmaier, Carlos Seas, Nancy Dianis, Antonio Moreno-Martinez, C Robert Horsburgh
BACKGROUND: Current guidelines for treatment of multidrug-resistant tuberculosis (MDR-TB) are largely based on expert opinion and observational data. Fluoroquinolones remain an essential part of MDR-TB treatment, but the optimal dose of fluoroquinolones as part of the regimen has not been defined. METHODS/DESIGN: We designed a randomized, blinded, phase II trial in MDR-TB patients comparing across levofloxacin doses of 11, 14, 17 and 20 mg/kg/day, all within an optimized background regimen...
November 25, 2017: Trials
https://www.readbyqxmd.com/read/29162188/from-child-maltreatment-to-emerging-adult-problem-drinking-identification-of-a-multilevel-internalizing-pathway-among-african-american-youth
#8
Elizabeth D Handley, Fred A Rogosch, Dante Cicchetti
The present study tested the role of FKBP5 binding protein 5 (FKBP5) genetic variation in an internalizing pathway from child maltreatment to emerging adult problem drinking among a sample of African American youth (N = 280) followed prospectively from ages 11 to 20. Specifically, whether childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies sequentially mediate the effect of child maltreatment on emerging adult problem drinking and whether FKBP5 moderates these associations were investigated...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29162187/methylation-of-the-glucocorticoid-receptor-gene-nuclear-receptor-subfamily-3-group-c-member-1-nr3c1-in-maltreated-and-nonmaltreated-children-associations-with-behavioral-undercontrol-emotional-lability-negativity-and-externalizing-and-internalizing-symptoms
#9
Dante Cicchetti, Elizabeth D Handley
The present study examined the effect of various dimensions of child maltreatment (i.e., developmental timing of maltreatment, number of maltreatment subtypes, and chronicity of maltreatment) on methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), and investigated the associations between NR3C1 methylation and child outcomes. Participants included 534 children who attended a research summer camp program for school-aged maltreated (53.4%) and nonmaltreated (46...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29158887/medical-imaging-lesion-detection-based-on-unified-gravitational-fuzzy-clustering
#10
Jean Marie Vianney Kinani, Alberto Jorge Rosales Silva, Francisco Gallegos Funes, Dante Mújica Vargas, Eduardo Ramos Díaz, Alfonso Arellano
We develop a swift, robust, and practical tool for detecting brain lesions with minimal user intervention to assist clinicians and researchers in the diagnosis process, radiosurgery planning, and assessment of the patient's response to the therapy. We propose a unified gravitational fuzzy clustering-based segmentation algorithm, which integrates the Newtonian concept of gravity into fuzzy clustering. We first perform fuzzy rule-based image enhancement on our database which is comprised of T1/T2 weighted magnetic resonance (MR) and fluid-attenuated inversion recovery (FLAIR) images to facilitate a smoother segmentation...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29155672/establishment-of-cdc-global-rapid-response-team-to-ensure-global-health-security
#11
Tasha Stehling-Ariza, Adrienne Lefevre, Dinorah Calles, Kpandja Djawe, Richard Garfield, Michael Gerber, Margherita Ghiselli, Coralie Giese, Ashley L Greiner, Adela Hoffman, Leigh Ann Miller, Lisa Moorhouse, Carlos Navarro-Colorado, James Walsh, Dante Bugli, Cyrus Shahpar
The 2014-2016 Ebola virus disease epidemic in West Africa highlighted challenges faced by the global response to a large public health emergency. Consequently, the US Centers for Disease Control and Prevention established the Global Rapid Response Team (GRRT) to strengthen emergency response capacity to global health threats, thereby ensuring global health security. Dedicated GRRT staff can be rapidly mobilized for extended missions, improving partner coordination and the continuity of response operations. A large, agencywide roster of surge staff enables rapid mobilization of qualified responders with wide-ranging experience and expertise...
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29138502/crystal-structures-of-the-mitochondrial-deacylase-sirtuin-4-reveal-isoform-specific-acyl-recognition-and-regulation-features
#12
Martin Pannek, Zeljko Simic, Matthew Fuszard, Marat Meleshin, Dante Rotili, Antonello Mai, Mike Schutkowski, Clemens Steegborn
Sirtuins are evolutionary conserved NAD(+)-dependent protein lysine deacylases. The seven human isoforms, Sirt1-7, regulate metabolism and stress responses and are considered therapeutic targets for aging-related diseases. Sirt4 locates to mitochondria and regulates fatty acid metabolism and apoptosis. In contrast to the mitochondrial deacetylase Sirt3 and desuccinylase Sirt5, no prominent deacylase activity and structural information are available for Sirt4. Here we describe acyl substrates and crystal structures for Sirt4...
November 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29130416/prevalence-incidence-and-associated-factors-of-pressure-ulcers-in-home-palliative-care-patients-a-retrospective-chart-review
#13
Marco Artico, Angelo Dante, Daniela D'Angelo, Luciano Lamarca, Chiara Mastroianni, Tommasangelo Petitti, Michela Piredda, Maria Grazia De Marinis
BACKGROUND: Terminally ill patients are at high risk of pressure ulcers, which have a negative impact on quality of life. Data about pressure ulcers' prevalence, incidence and associated factors are largely insufficient. AIM: To document the point prevalence at admission and the cumulative incidence of pressure ulcers in terminally ill patients admitted to an Italian home palliative care unit, and to analyse the patients' and caregivers' characteristics associated with their occurrence...
October 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29122711/developmental-refinement-of-synaptic-transmission-on-micropatterned-single-layer-graphene
#14
Sandeep Keshavan, Shovan Naskar, Alberto Diaspro, Laura Cancedda, Silvia Dante
Interfacing neurons with a single atomic layer of graphene, single atomic layer of sp2 hybridized C-atoms, is a key paradigm in understanding how to exploit the unique properties of such a two-dimensional system for neural prosthetics and biosensors development. In order to fabricate graphene-based circuitry, a reliable large area patterning method is a requirement. Following a previously developed protocol, we monitored the in vitro neuronal development of geometrically ordered neural network growing onto patterned Single Layer Graphene (SLG) coated with poly-D-lysine...
November 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29121899/p21-mice-exhibit-enhanced-bone-regeneration-after-injury
#15
Priyatha Premnath, Britta Jorgenson, Ricarda Hess, Pankaj Tailor, Dante Louie, Jaymi Taiani, Steven Boyd, Roman Krawetz
BACKGROUND: p21((WAF1/CIP1/SDI1)), a cyclin dependent kinase inhibitor has been shown to influence cell proliferation, differentiation and apoptosis; but more recently, p21 has been implicated in tissue repair. Studies on p21((-/-)) knockout mice have demonstrated results that vary from complete regeneration and healing of tissue to attenuated healing. There have however been no studies that have evaluated the role of p21 inhibition in bone healing and remodeling. METHODS: The current study employs a burr-hole fracture model to investigate bone regeneration subsequent to an injury in a p21(-/-) mouse model...
November 9, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29117026/the-american-association-for-the-surgery-of-trauma-severity-grade-is-valid-and-generalizable-in-adhesive-small-bowel-obstruction
#16
Martin D Zielinski, Nadeem N Haddad, Asad Choudhry, Matthew C Hernandez, Daniel C Cullinane, David Turay, Ji-Ming Yune, Salina Wydo, Kenji Inaba, D Dante Yeh, Therese M Duane, Andrea Pakula, Ruby Skinner, Jill Watras, Carlos J Rodriguez, Kenneth A Widom, John Cull, Julie Dunn, Eric A Toschlog, Valerie G Sams, John C Graybill
INTRODUCTION: The American Association for the Surgery of Trauma (AAST) anatomic severity grading system for adhesive small bowel obstruction (ASBO) was validated at a single institution. We aimed to externally validate the AAST ASBO grading system using the Eastern Association for the Surgery of Trauma (EAST) multi-institutional SBO prospective observational study. METHODS: Adults (age≥18) with (ASBO) were included. Baseline demographics, physiologic parameters (heart rate, blood pressure, respiratory rate), labs (lactate, hemoglobin, creatinine, leukocytosis), imaging findings, operative details, length of stay, and Clavien-Dindo complications were collected...
November 7, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29116336/analysis-of-primary-tumor-metabolic-volume-during-chemoradiotherapy-in-locally-advanced-non-small-cell-lung-cancer
#17
Olarn Roengvoraphoj, Cherylina Wijaya, Chukwuka Eze, Minglun Li, Maurice Dantes, Julian Taugner, Amanda Tufman, Rudolf Maria Huber, Claus Belka, Farkhad Manapov
PURPOSE: Positron emission tomography with 2‑deoxy-2-[fluorine-18] fluoro-d-glucose integrated with computed tomography (18F-FDG-PET/CT) has an established role in the initial diagnosis and staging of lung cancer. However, a prognostic value of PET/CT during multimodality treatment has not yet been fully clarified. This study evaluated the role of primary tumor metabolic volume (PT-MV) changes on PET/CT before, during, and after chemoradiotherapy (CRT). METHODS: A total of 65 patients with non-small-cell lung cancer (NSCLC) UICC stage IIIA/B (TNM 7th Edition) were treated with definitive chemoradiotherapy (sequential or concurrent setting)...
November 7, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29108729/-liquid-crystalline-systems-based-on-glyceryl-monooleate-and-penetration-enhancers-for-skin-delivery-of-celecoxib-characterization-in-vitro-drug-release-and-in-vivo-studies
#18
Mariane de Cássia Lima Dante, Livia Neves Borgheti-Cardoso, Marcia Carvalho de Abreu Fantini, Fabíola Silva Garcia Praça, Wanessa Silva Garcia Medina, Maria Bernadete Riemma Pierre, Marilisa Guimarães Lara
Celecoxib (CXB) is a widely used anti-inflammatory drug that also acts as a chemopreventive agent against several types of cancer, including skin cancer. As the long-term oral administration of CXB has been associated with severe side effects, the skin delivery of this drug represents a promising alternative for the treatment of skin inflammatory conditions and/or chemoprevention of skin cancer. We prepared and characterized liquid crystalline systems based on glyceryl monooleate (GMO) and water containing penetration enhancers which were primarily designed to promote skin delivery of CXB...
November 3, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29106289/insertion-of-fully-covered-self-expanding-metal-stents-in-benign-biliary-diseases
#19
Mariana Omodeo, Ignacio Malaga, Dante Manazzoni, Cecilia Curvale, Julio de Maria, Martín Alejandro Guidi, Raúl Matano
INTRODUCTION: Benign biliary diseases are traditionally treated using plastic stents. However, fully covered self-expanding metal stents are currently gaining acceptance for the treatment of these pathologies. OBJECTIVE: To assess the effectiveness and complications associated with the placement of temporary endoscopic fully covered self-expanding metal stents for the treatment of benign biliary diseases. MATERIALS AND METHODS: This was a retrospective and observational study using a prospective database from a tertiary care center from March 2012 to May 2016...
November 6, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29104422/capsule-implosions-for-continuum-x-ray-backlighting-of-opacity-samples-at-the-national-ignition-facility
#20
Y P Opachich, R F Heeter, M A Barrios, E M Garcia, R S Craxton, J A King, D A Liedahl, P W McKenty, M B Schneider, M J May, R Zhang, P W Ross, J L Kline, A S Moore, J L Weaver, K A Flippo, T S Perry
Direct drive implosions of plastic capsules have been performed at the National Ignition Facility to provide a broad-spectrum (500-2000 eV) X-ray continuum source for X-ray transmission spectroscopy. The source was developed for the high-temperature plasma opacity experimental platform. Initial experiments using 2.0 mm diameter polyalpha-methyl styrene capsules with ∼20 μm thickness have been performed. X-ray yields of up to ∼1 kJ/sr have been measured using the Dante multichannel diode array. The backlighter source size was measured to be ∼100 μm FWHM, with ∼350 ps pulse duration during the peak emission stage...
June 2017: Physics of Plasmas
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