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https://www.readbyqxmd.com/read/28429850/association-of-obstructive-sleep-apnea-with-arterial-stiffness-and-nondipping-blood-pressure-in-patients-with-hypertension
#1
Raimundo Jenner, Fernanda Fatureto-Borges, Valéria Costa-Hong, Heno F Lopes, Sandra H Teixeira, Elias Marum, Dante A M Giorgi, Fernanda M Consolim-Colombo, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Eduardo M Krieger, Luciano F Drager
Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11...
April 21, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28429760/corrigendum-selective-targeting-of-hdac1-2-elicits-anticancer-effects-through-gli1-acetylation-in-preclinical-models-of-shh-medulloblastoma
#2
Sonia Coni, Anna Barbara Mancuso, Laura Di Magno, Giulia Sdruscia, Simona Manni, Silvia Maria Serrao, Dante Rotili, Eleonora Spiombi, Francesca Bufalieri, Marialaura Petroni, Monika Kusio-Kobialka, Enrico De Smaele, Elisabetta Ferretti, Carlo Capalbo, Antonello Mai, Pawel Niewiadomski, Isabella Screpanti, Lucia Di Marcotullio, Gianluca Canettieri
No abstract text is available yet for this article.
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427542/recurrent-respiratory-papillomatosis-a-state-of-the-art-review
#3
REVIEW
Helena Ribeiro Fortes, Felipe Mussi von Ranke, Dante Luiz Escuissato, Cesar Augusto Araujo Neto, Gláucia Zanetti, Bruno Hochhegger, Carolina Althoff Souza, Edson Marchiori
Recurrent respiratory papillomatosis (RRP) is a benign disease of the upper aero-digestive tract caused by human papillomavirus (HPV) infection, which affects children and young adults. The aim of this review is to describe the main etiological, epidemiological, clinical, diagnostic, and treatment aspects of RRP. Most infections in children occur at birth, during passage through the birth canals of contaminated mothers. In adults, HPV is transmitted sexually. Papillomas usually appear as exophytic nodules, primarily in the larynx, but occasionally involving the nasopharynx, tracheobronchial tree, and pulmonary parenchyma...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28426940/prospective-assessment-of-virtual-screening-heuristics-derived-using-a-novel-fusion-score
#4
Dante A Pertusi, Gregory O'Donnell, Michelle F Homsher, Kelli Solly, Amita Patel, Shannon L Stahler, Daniel Riley, Michael F Finley, Eleftheria N Finger, Gregory C Adam, Juncai Meng, David J Bell, Paul D Zuck, Edward M Hudak, Michael J Weber, Jennifer E Nothstein, Louis Locco, Carissa Quinn, Adam Amoss, Brian Squadroni, Michelle Hartnett, Mee Ra Heo, Tara White, S Alex May, Evelyn Boots, Kenneth Roberts, Patrick Cocchiarella, Alex Wolicki, Anthony Kreamer, Peter S Kutchukian, Anne Mai Wassermann, Victor N Uebele, Meir Glick, Andrew Rusinko, J Christopher Culberson
High-throughput screening (HTS) is a widespread method in early drug discovery for identifying promising chemical matter that modulates a target or phenotype of interest. Because HTS campaigns involve screening millions of compounds, it is often desirable to initiate screening with a subset of the full collection. Subsequently, virtual screening methods prioritize likely active compounds in the remaining collection in an iterative process. With this approach, orthogonal virtual screening methods are often applied, necessitating the prioritization of hits from different approaches...
April 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28426557/loop-ileostomy-vs-total-colectomy-as-surgical-treatment-for-clostridium-difficile-associated-disease-an-eastern-association-for-the-surgery-of-trauma-multicenter-trial
#5
Paula Ferrada, Rachael Callcut, Martin D Zielinski, Brandon Bruns, Daniel Dante Yeh, Tanya L Zakrison, Jonathan P Meizoso, Babak Sarani, Richard D Catalano, Peter Kim, Valerie Plant, Amelia Pasley, Linda A Dultz, Asad J Choudhry, Elliott R Haut
OBJECTIVES: The mortality of patients with Clostridum Dificile Associated Disease (CDAD) requiring surgery continues to be very high. Loop ileostomy (LI) was introduced as an alternative procedure to total colectomy (TC) for CDAD by a single center study. To date, no reproducible results have been published. The objective of this study is to compare these two procedures in a multicentric approach to help the surgeon decide what procedure is best suited for the patient in need. METHODS: This was a retrospective multicenter study conducted under the sponsorship of the Eastern Association for the Surgery of Trauma (EAST)...
April 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28422909/multi-institutional-prospective-observational-study-comparing-the-gastrografin-challenge-versus-standard-treatment-in-adhesive-small-bowel-obstruction
#6
Martin D Zielinski, Nadeem N Haddad, Asad J Choudhry, Daniel C Cullinane, Kenji Inaba, Agustin Escalante, D Dante Yeh, Salina Wydo, David Turay, Andrea Pakula, Therese M Duane, Jill Watras, Kenneth A Widom, John Cull, Carlos J Rodriguez, Eric A Toschlog, Valerie G Sams, Joshua P Hazelton, John Christopher Graybill
INTRODUCTION: Existing trials studying the use of Gastrografin for management of adhesive small bowel obstruction (SBO) are limited by methodological flaws and small sample sizes. We compared institutional protocols with and without Gastrografin (GG), hypothesizing that a SBO management protocol utilizing GG is associated with lesser rates of exploration, shorter length of stay, and fewer complications. METHODS: A multi-institutional, prospective, observational study was performed on patients appropriate for GG with adhesive SBO...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28422908/the-emergency-surgery-score-ess-accurately-predicts-the-occurrence-of-postoperative-complications-in-emergency-surgery-patients
#7
Anirudh R Nandan, Jordan D Bohnen, Naveen F Sangji, Thomas Peponis, Kelsey Han, D Dante Yeh, Jarone Lee, Noelle Saillant, Marc De Moya, George C Velmahos, David C Chang, Haytham M A Kaafarani
BACKGROUND: The Emergency Surgery Score (ESS) was recently validated as a scoring system to predict mortality in emergency surgery (ES) patients. We sought to examine the ability of ESS to predict the occurrence of 30-day postoperative complications in ES. METHODS: The 2011-2012 American College of Surgeons National Surgical Quality.Improvement Program (ACS-NSQIP) database was screened for all surgical operations classified as "emergent". Thirty-day postoperative complications were defined as per ACS-NSQIP (e...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28401849/developmental-cascade-effects-of-interpersonal-psychotherapy-for-depressed-mothers-longitudinal-associations-with-toddler-attachment-temperament-and-maternal-parenting-efficacy
#8
Elizabeth D Handley, Louisa C Michl-Petzing, Fred A Rogosch, Dante Cicchetti, Sheree L Toth
Using a developmental cascades framework, the current study investigated whether treating maternal depression via interpersonal psychotherapy (IPT) may lead to more widespread positive adaptation for offspring and mothers including benefits to toddler attachment and temperament, and maternal parenting self-efficacy. The participants (N = 125 mother-child dyads; mean mother age at baseline = 25.43 years; 54.4% of mothers were African American; mean offspring age at baseline = 13.23 months) were from a randomized controlled trial of IPT for a sample of racially and ethnically diverse, socioeconomically disadvantaged mothers of infants...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28401848/attachment-security-mediates-the-longitudinal-association-between-child-parent-psychotherapy-and-peer-relations-for-toddlers-of-depressed-mothers
#9
Danielle J Guild, Sheree L Toth, Elizabeth D Handley, Fred A Rogosch, Dante Cicchetti
Numerous investigations have demonstrated that child-parent psychotherapy (CPP) promotes secure attachment between mothers and offspring. However, the role of postintervention attachment security as it relates to long-term child outcomes has never been evaluated. The present study therefore examined postintervention attachment status as a mediator of the association between CPP for depressed mothers and their offspring and subsequent peer relations among offspring. Depressed mothers and their toddlers were randomized to receive CPP (n = 45) or to a control group (n = 55)...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28401829/attachment-states-of-mind-and-inferred-childhood-experiences-in-maltreated-and-comparison-adolescents-from-low-income-families
#10
Glenn I Roisman, Fred A Rogosch, Dante Cicchetti, Ashley M Groh, John D Haltigan, Katherine C Haydon, Ashley S Holland, Ryan D Steele
This paper reports the first large-sample investigation of the maltreatment-related correlates of low-income adolescents' narratives about their childhood experiences with primary caregivers, as assessed with a modified version of the Adult Attachment Interview (AAI) and based on official reports of abuse and neglect (maltreated n = 214, nonmaltreated n = 140; M age = 16.7 years). Drawing on factor-analytic and taxometric evidence indicating that AAI narratives vary along two state of mind (i.e., dismissing and preoccupied) and two inferred childhood experience (i...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28401827/attachment-in-the-context-of-atypical-caregiving
#11
Glenn I Roisman, Dante Cicchetti
No abstract text is available yet for this article.
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28400850/validity-assessment-of-the-promis-fatigue-domain-among-people-living-with-hiv
#12
L E Gibbons, R Fredericksen, D S Batey, L Dant, T C Edwards, K H Mayer, W C Mathews, L S Morales, M J Mugavero, F M Yang, E Paez, M M Kitahata, D L Patrick, H M Crane, P K Crane
PURPOSE: To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS(®) Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. METHODS: Cross-sectional and longitudinal fatigue data were collected from September 2012 through April 2013 across clinics participating in the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS)...
2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28399938/validity-assessment-of-the-promis-fatigue-domain-among-people-living-with-hiv
#13
L E Gibbons, R Fredericksen, D S Batey, L Dant, T C Edwards, K H Mayer, W C Mathews, L S Morales, M J Mugavero, F M Yang, E Paez, M M Kitahata, D L Patrick, H M Crane, P K Crane
PURPOSE: To evaluate psychometric characteristics and cross-sectional and longitudinal validity of the 7-item PROMIS(®) Fatigue Short Form and additional fatigue items among people living with HIV (PLWH) in a nationally distributed network of clinics collecting patient reported data at the time of routine clinical care. METHODS: Cross-sectional and longitudinal fatigue data were collected from September 2012 through April 2013 across clinics participating in the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS)...
April 11, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28399551/risks-factors-for-reoperation-in-patients-treated-surgically-for-degenerative-spondylolisthesis-a-subanalysis-of-the-8-year-data-from-the-sport-trial
#14
Michael C Gerling, Dante Leven, Peter G Passias, Virgnie Lafage, Kristina Bianco, Alexandra Lee, Tamara S Morgan, Jon D Lurie, Tor D Tosteson, Wenyan Zhao, Kevin F Spratt, Kristen Radcliff, Thomas J Errico
STUDY DESIGN: Retrospective analysis of prospective data from the degenerative spondylolisthesis (DS) arm of the Spine Patient Outcomes Research Trial. OBJECTIVE: To identify risk factors for reoperation in patients treated surgically for DS and compare outcomes between patients who underwent reoperation with non-reoperative patients. SUMMARY OF BACKGROUND DATA: Several studies have examined outcomes following surgery for DS, but few have identified risk factors for reoperation...
April 10, 2017: Spine
https://www.readbyqxmd.com/read/28397610/the-mediating-roles-of-cortisol-reactivity-and-executive-functioning-difficulties-in-the-pathways-between-childhood-histories-of-emotional-insecurity-and-adolescent-school-problems
#15
Meredith J Martin, Patrick T Davies, E Mark Cummings, Dante Cicchetti
This study tested a hypothesized cascade in which children's insecure representations of the interparental relationship increase their school problems by altering children's cortisol reactivity to stress and their executive functioning. Participants included 235 families. The first of five measurement occasions occurred when the children were in kindergarten (M age = 6 years), and they were followed through the transition to high school. The results indicated that children's histories of insecure representations of the interparental relationship during the early school years were associated with executive functioning difficulties in adolescence (M age = 14 years)...
April 11, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28391962/su9516-increases-%C3%AE-7%C3%AE-1-integrin-and-ameliorates-disease-progression-in-the-mdx-mouse-model-of-duchenne-muscular-dystrophy
#16
Apurva Sarathy, Ryan D Wuebbles, Tatiana M Fontelonga, Ashley R Tarchione, Lesley A Mathews Griner, Dante J Heredia, Andreia M Nunes, Suzann Duan, Paul D Brewer, Tyler Van Ry, Grant W Hennig, Thomas W Gould, Andrés E Dulcey, Amy Wang, Xin Xu, Catherine Z Chen, Xin Hu, Wei Zheng, Noel Southall, Marc Ferrer, Juan Marugan, Dean J Burkin
Duchenne muscular dystrophy (DMD) is a fatal muscle disease caused by mutations in the dystrophin gene, resulting in a complete loss of the dystrophin protein. Dystrophin is a critical component of the dystrophin glycoprotein complex (DGC), which links laminin in the extracellular matrix to the actin cytoskeleton within myofibers and provides resistance to shear stresses during muscle activity. Loss of dystrophin in DMD patients results in a fragile sarcolemma prone to contraction-induced muscle damage. The α7β1 integrin is a laminin receptor protein complex in skeletal and cardiac muscle and a major modifier of disease progression in DMD...
April 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28386778/gaba-content-within-medial-prefrontal-cortex-predicts-the-variability-of-fronto-limbic-effective-connectivity
#17
Stefano Delli Pizzi, Piero Chiacchieretta, Dante Mantini, Giovanna Bubbico, Richard A Edden, Marco Onofrj, Antonio Ferretti, Laura Bonanni
The amygdala-medial prefrontal cortex (mPFC) circuit plays a key role in social behavior. The amygdala and mPFC are bidirectionally connected, functionally and anatomically, via the uncinate fasciculus. Recent evidence suggests that GABA-ergic neurotransmission within the mPFC could be central to the regulation of amygdala activity related to emotions and anxiety processing. However, the functional and neurochemical interactions within amygdala-mPFC circuits are unclear. In the current study, multimodal magnetic resonance imaging techniques were combined to investigate effective connectivity within the amygdala-mPFC network and its relationship with mPFC neurotransmission in 22 healthy subjects aged between 41 and 88 years...
April 6, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28385876/concurrent-tacs-fmri-reveals-causal-influence-of-power-synchronized-neural-activity-on-resting-state-fmri-connectivity
#18
Marc Bächinger, Valerio Zerbi, Marius Moisa, Rafael Polania, Quanying Liu, Dante Mantini, Christian Ruff, Nicole Wenderoth
Resting state fMRI (rs-fMRI) is commonly used to study the brain's intrinsic neural coupling, which reveals specific spatiotemporal patterns in the form of resting state networks (RSN). It has been hypothesized that slow rs-fMRI oscillations (<0.1 Hz) are driven by underlying electrophysiological rhythms that typically occur at much faster timescales (>5 Hz); however, causal evidence for this relationship is currently lacking. Here we measured rs-fMRI in humans while applying transcranial alternating current stimulation (tACS) to entrain brain rhythms in left and right sensorimotor cortices...
April 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28384557/from-tooth-extraction-to-gorham-stout-disease-a-case-report
#19
Gabriele Bocchialini, Luca Ferrari, Dante Burlini
INTRODUCTION: Gorham-Stout disease (GSD), or vanishing bone disease, is a very rare condition of unknown aetiology. It is characterised by progressive osteolysis and angiomatosis. CASE PRESENTATION: We report the discovery of this very rare disease following a trivial deciduous tooth extraction in a 14-year-old female. We focus initially on the difference between the preoperative orthopantomography and the whole-body computed tomography and magnetic resonance images obtained post-haemorrhage, and then on the improvement of strategies for the correct diagnosis and treatment of this disease...
March 21, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28378195/characterization-of-ostertagia-ostertagi-annexin-like-proteins-at-different-developmental-stages
#20
Pooja Sharma, Mark Jenkins, Dante Zarlenga, Ray Fetterer, Zhengguo Xiao, Wenbin Tuo
Ostertagiosis remains an economically important parasitic disease in cattle in the temperate regions of the world. Repeated exposures to Ostertagia ostertagi in calves cause significant pathology in the abomasum but elicit little protective immunity. The larvae use the host's gastric glands as a niche for development, where the parasite completes its parasitic stages, while in the gastric glands, the larvae must down-regulate the host inflammatory immune responses. Annexin (ANX) A1, commonly found in most eukaryotes, is heavily involved in controlling anti-inflammatory responses by binding receptors on leukocytes...
March 29, 2017: Parasitology Research
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