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https://www.readbyqxmd.com/read/29456915/short-term-complications-of-anterior-fixation-of-odontoid-fractures
#1
Holt S Cutler, Javier Z Guzman, Nathan J Lee, Parth Kothari, Jun S Kim, John I Shin, Dante M Leven, Samuel K Cho
Study Design: Retrospective study. Objective: Anterior fixation of odontoid fracture has been associated with high morbidity and mortality in small, single institution series. Identifying risk factors may improve risk stratification and highlight factors that could be optimized preoperatively. The objective of this study was to determine the 30-day complication rate following anterior fixation of odontoid fractures and to identify associated risk factors among patients in a large national database...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456770/recurrent-oral-eosinophilic-ulcers-of-the-oral-mucosa-a-case-report
#2
Norberto Sugaya, Fernanda Martignago, Decio Pinto, Dante Migliari
Objective: This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman. Introduction: The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29454149/study-of-manganese-binding-to-the-ferroxidase-centre-of-human-h-type-ferritin
#3
Matteo Ardini, Barry D Howes, Annarita Fiorillo, Elisabetta Falvo, Silvia Sottini, Donella Rovai, Marco Lantieri, Andrea Ilari, Dante Gatteschi, Gabriele Spina, Emilia Chiancone, Simonetta Stefanini, Maria Fittipaldi
Ferritins are ubiquitous and conserved proteins endowed with enzymatic ferroxidase activity, that oxidize Fe(II) ions at the dimetal ferroxidase centre to form a mineralized Fe(III) oxide core deposited within the apo-protein shell. Herein, the in vitro formation of a heterodimetal cofactor constituted by Fe and Mn ions has been investigated in human H ferritin (hHFt). Namely, Mn and Fe binding at the hHFt ferroxidase centre and its effects on Fe(II) oxidation have been investigated by UV-Vis ferroxidation kinetics, fluorimetric titrations, multifrequency EPR, and preliminary Mössbauer spectroscopy...
February 9, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29453102/preparation-of-plga-rose-bengal-colloidal-particles-by-double-emulsion-and-layer-by-layer-for-breast-cancer-treatment
#4
María F Loya-Castro, Mariana Sánchez-Mejía, Dante R Sánchez-Ramírez, Rossina Domínguez-Ríos, Noé Escareño, Paola E Oceguera-Basurto, Édgar B Figueroa-Ochoa, Antonio Quintero, Alicia Del Toro-Arreola, Antonio Topete, Adrián Daneri-Navarro
The use of colloidal particles (CPs) in the transport of drugs is developing rapidly thanks to its effectiveness and biosafety, especially in the treatment of various types of cancer. In this study Rose Bengal/PLGA CPs synthesized by double emulsion (W/O/W) and by electrostatic adsorption (layer-by-layer), were characterized and evaluated as potential breast cancer treatment. CPs were evaluated in terms of size, zeta potential, drug release kinetics and cell viability inhibition efficacy with the triple negative breast cancer cell line HCC70...
February 7, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29451309/antibodies-to-human-neutrophil-antigen-hna-3b-implicated-in-cases-of-neonatal-alloimmune-neutropenia
#5
Larissa Barbosa Lopes, Samira Ali Abbas, Elyse Moritz, Juliana Oliveira Martins, Akemi Kuroda Chiba, Dante Mário Langhi, José O Bordin
BACKGROUND: Neonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a; however, to date, antibodies specific to HNA-3b have not been reported. STUDY DESIGN AND METHODS: Blood samples from 10,000 unselected neonates were analyzed, resulting in the selection of 88 neutropenic newborns (neutrophil count <1...
February 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29447849/three-dimensional-arterial-spin-labeling-imaging-with-a-dante-preparation-pulse
#6
Tsuyoshi Matsuda, Hirohiko Kimura, Hiroyuki Kabasawa, Masayuki Kanamoto
On arterial spin-labeled (ASL) images, areas of bright intravascular signal will appear when the post labeling delay time is shorter than arterial transit time. Vascular suppression (VS) schemes reduce artefactual bright signal by dephasing intravascular labeled spins. However, existing VS methods, such as Motion-Sensitized Driven-Equilibrium (MSDE), decrease the uniformity of the signal intensity distribution and extend the echo time. The purpose of this study is to compare VS using a Delays Alternating with Nutation for Tailored Excitation (DANTE) preparation pulse, with MSDE for ASL imaging on a flow phantom and volunteer data...
February 12, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29443854/universal-screening-for-intimate-partner-and-sexual-violence-in-trauma-patients-what-about-the-men-an-east-multicenter-trial
#7
Tanya L Zakrison, Rishi Rattan, Davel Milian Valdés, Xiomara Ruiz, Rondi Gelbard, John Cline, David Turay, Xian Luo-Owen, Nicholas Namias, Jessica George, Dante Yeh, Daniel Pust, Brian H Williams
INTRODUCTION: A recent EAST-supported, multicenter trial demonstrated a similar rate of intimate partner and sexual violence (IPSV) between male and female trauma patients, regardless of mechanism. Our objective was to perform a subgroup analysis of our affected male cohort as this remains an understudied group in the trauma literature. METHODS: We conducted a recent EAST-supported, cross-sectional, multicenter trial over one year (03/15-04/16) involving four Level I trauma centers throughout the United States...
February 14, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29433482/cholesterol-of-lipid-rafts-is-a-key-determinant-for-entry-and-post-entry-control-of-porcine-rotavirus-infection
#8
Xiujing Dou, Yang Li, Junlan Han, Dante S Zarlenga, Weijuan Zhu, Xiaofeng Ren, Na Dong, Xunliang Li, Guangxing Li
BACKGROUND: Lipid rafts are major structural components in plasma membranes that play critical roles in many biological processes including virus infection. However, few reports have described the relationship between lipid rafts and porcine rotavirus (PRV) infection. In this study, we investigated whether or not the locally high concentrations (3-5 fold) of cholesterol present in lipid rafts are required for PRV infection, and further examined which stages of the infection process are most affected...
February 12, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29427251/heart-brain-interactions-in-the-mr-environment-characterization-of-the-ballistocardiogram-in-eeg-signals-collected-during-simultaneous-fmri
#9
Marco Marino, Quanying Liu, Mariangela Del Castello, Cristiana Corsi, Nicole Wenderoth, Dante Mantini
The ballistocardiographic (BCG) artifact is linked to cardiac activity and occurs in electroencephalographic (EEG) recordings acquired inside the magnetic resonance (MR) environment. Its variability in terms of amplitude, waveform shape and spatial distribution over subject's scalp makes its attenuation a challenging task. In this study, we aimed to provide a detailed characterization of the BCG properties, including its temporal dependency on cardiac events and its spatio-temporal dynamics. To this end, we used high-density EEG data acquired during simultaneous functional MR imaging in six healthy volunteers...
February 9, 2018: Brain Topography
https://www.readbyqxmd.com/read/29415003/the-rise-of-health-biotechnology-research-in-latin-america-a-scientometric-analysis-of-health-biotechnology-production-and-impact-in-argentina-brazil-chile-colombia-cuba-and-mexico
#10
Dante Israel León-de la O, Halla Thorsteinsdóttir, José Víctor Calderón-Salinas
This paper analyzes the patterns of health biotechnology publications in six Latin American countries from 2001 to 2015. The countries studied were Argentina, Brazil, Chile, Colombia, Cuba and Mexico. Before our study, there were no data available on HBT development in half of the Latin-American countries we studied, i.e., Argentina, Colombia and Chile. To include these countries in a scientometric analysis of HBT provides fuller coverage of HBT development in Latin America. The scientometric study used the Web of Science database to identify health biotechnology publications...
2018: PloS One
https://www.readbyqxmd.com/read/29408354/increased-gradients-after-aortic-valve-replacement-with-the-perceval-valve-the-role-of-oversizing
#11
Alfredo Giuseppe Cerillo, Francesca Amoretti, Massimiliano Mariani, Emanuele Cigala, Michele Murzi, Tommaso Gasbarri, Marco Solinas, Dante Chiappino
BACKGROUND: Significant underexpansion or distortion of valved stents may be associated with altered leaflet function, leading to increased transprosthetic gradients and, possibly, early structural degeneration. We investigated the relationship between a computed tomography (CT) measure of the degree of oversizing and the early haemodynamic and clinical outcomes in patients undergoing aortic valve replacement with the Perceval sutureless aortic valve. METHODS: The degree of oversizing of the implanted prosthesis was calculated as the ratio between the patients' aortic annulus cross-sectional area (CSA) and the ex-vivo CSA of the implanted prosthesis in 151 perceval patients that had a preoperative cardiac CT...
February 2, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29392162/combining-intraoperative-ultrasound-brain-shift-correction-and-augmented-reality-visualizations-a-pilot-study-of-eight-cases
#12
Ian J Gerard, Marta Kersten-Oertel, Simon Drouin, Jeffery A Hall, Kevin Petrecca, Dante De Nigris, Daniel A Di Giovanni, Tal Arbel, D Louis Collins
We present our work investigating the feasibility of combining intraoperative ultrasound for brain shift correction and augmented reality (AR) visualization for intraoperative interpretation of patient-specific models in image-guided neurosurgery (IGNS) of brain tumors. We combine two imaging technologies for image-guided brain tumor neurosurgery. Throughout surgical interventions, AR was used to assess different surgical strategies using three-dimensional (3-D) patient-specific models of the patient's cortex, vasculature, and lesion...
April 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29384525/mtor-inhibitor-based-combination-therapies-for-pancreatic-cancer
#13
Zonera Hassan, Christian Schneeweis, Matthias Wirth, Christian Veltkamp, Zahra Dantes, Benedikt Feuerecker, Güralp O Ceyhan, Shirley K Knauer, Wilko Weichert, Roland M Schmid, Roland Stauber, Alexander Arlt, Oliver H Krämer, Roland Rad, Maximilian Reichert, Dieter Saur, Günter Schneider
BACKGROUND: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. METHODS: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance...
January 2, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29384476/activity-induced-ca2-signaling-in-perisynaptic-schwann-cells-of-the-early-postnatal-mouse-is-mediated-by-p2y1-receptors-and-regulates-muscle-fatigue
#14
Dante J Heredia, Cheng-Yuan Feng, Grant W Hennig, Robert B Renden, Thomas W Gould
Perisynaptic glial cells respond to neural activity by increasing cytosolic calcium, but the significance of this pathway is unclear. Terminal/perisynaptic Schwann cells (TPSCs) are a perisynaptic glial cell at the neuromuscular junction that respond to nerve-derived substances such as acetylcholine and purines. Here, we provide genetic evidence that activity-induced calcium accumulation in neonatal TPSCs is mediated exclusively by one subtype of metabotropic purinergic receptor. In P2ry1 mutant mice lacking these responses, postsynaptic, rather than presynaptic, function was altered in response to nerve stimulation...
January 31, 2018: ELife
https://www.readbyqxmd.com/read/29383558/peri-procedural-antithrombotic-management-time-to-burn-the-bridge
#15
Jessica Marquez, John C Togami, Colton R Dant, Amanda Herrera, Patricia Marshik, Allison E Burnett
Emerging evidence suggests the use of peri-procedural bridging during interruptions in warfarin therapy increases bleed risk without reducing thromboembolic events. We implemented a peri-procedural anticoagulant management risk assessment tool in a single, outpatient anticoagulation clinic within an academic teaching institution. In this retrospective, pre-post observational study, we evaluated adults who required an interruption in warfarin therapy for an invasive procedure. The primary outcome was the proportion of patients who received bridging prior to and following implementation of the tool...
January 30, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29381339/structure-and-enzymatic-properties-of-an-unusual-cysteine-tryptophylquinone-dependent-glycine-oxidase-from-pseudoalteromonas-luteoviolacea
#16
Andres Andreo-Vidal, Kyle Mamounis, Esha Sehanobish, Dante Avalos, Jonatan Cristian Campillo-Brocal, Antonio Sanchez-Amat, Erik Thomas Yukl, Victor L Davidson
Glycine oxidase from Pseudoalteromonas luteoviolacea (PlGoxA) is a cysteine tryptophylquinone (CTQ)-dependent enzyme. Sequence and phylogenetic analysis place it in a newly designated subgroup (Group IID) of a recently identified family of LodA-like proteins, which are predicted to possess CTQ. The crystal structure of PlGoxA reveals that it is a homo-tetramer. It possesses an N-terminal domain with no close structural homologues in the Protein Data Bank. The active site is quite small due to inter-subunit interactions, which may account for the observed cooperativy towards glycine...
January 30, 2018: Biochemistry
https://www.readbyqxmd.com/read/29373740/structural-properties-and-gene-silencing-activity-of-chemically-modified-dna-rna-hybrids-with-parallel-orientation
#17
Maryam Habibian, Maryam Yahyaee-Anzahaee, Matije Lucic, Elena Moroz, Nerea Martín-Pintado, Logan Dante Di Giovanni, Jean-Christophe Leroux, Jonathan Hall, Carlos González, Masad J Damha
We report, herein, a new class of RNAi trigger molecules based on the unconventional parallel hybridization of two oligonucleotide chains. We have prepared and studied several parallel stranded (ps) duplexes, in which the parallel orientation is achieved through incorporation of isoguanine and isocytosine to form reverse Watson-Crick base pairs in ps-DNA:DNA, ps-DNA:RNA, ps-(DNA-2'F-ANA):RNA, and ps-DNA:2'F-RNA duplexes. The formation of these duplexes was confirmed by UV melting experiments, FRET and CD studies...
January 24, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29373479/orthostatic-hypotension-in-older-persons-is-not-associated-with-cognitive-functioning-features-of-cerebral-damage-or-cerebral-blood-flow
#18
Jessica C Foster-Dingley, Justine E F Moonen, Wouter de Ruijter, Roos C van der Mast, Jeroen van der Grond
OBJECTIVE: Particularly in old age, orthostatic hypotension has been related to worse cognitive functioning, possibly caused by reduced cerebral blood flow (CBF). This study investigates whether orthostatic hypotension in older people is associated with cognitive dysfunction and, if so, whether this association is mediated by cerebral vascular damage and/or decreased CBF. METHODS: Four hundred and twenty participants of the Discontinuation of ANtihypertensive Treatment in Elderly People (DANTE) Study Leiden (mean age 81 years, all using antihypertensive medication and with mild cognitive deficits), and MRI data from 214 participants of the nested DANTE MRI sub-study...
January 25, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29364999/laryngotracheobronchial-papillomatosis-chest-ct-findings
#19
Helena Ribeiro Fortes, Felipe Mussi von Ranke, Dante Luiz Escuissato, Cesar Augusto Araujo Neto, Gláucia Zanetti, Bruno Hochhegger, Klaus Loureiro Irion, Carolina Althoff Souza, Edson Marchiori
To evaluate the findings on chest CTs in 16 patients (8 men and 8 women) with laryngotracheobronchial papillomatosis. This was a retrospective study involving patients ranging from 2 to 72 years of age. The evaluation of the CT scans was independently performed by two observers, and discordant results were resolved by consensus. The inclusion criteria were presence of abnormalities on the CT scans, and the diagnosis was confirmed by anatomopathological examination of the papillomatous lesions. The most common symptoms were hoarseness, cough, dyspnea, and recurrent respiratory infections...
July 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29360610/early-nutritional-inadequacy-is-associated-with-psoas-muscle-deterioration-and-worse-clinical-outcomes-in-critically-ill-surgical-patients
#20
Daniel Dante Yeh, Luis Alfonso Ortiz-Reyes, Sadeq A Quraishi, Nalin Chokengarmwong, Laura Avery, Haytham M A Kaafarani, Jarone Lee, Peter Fagenholz, Yuchiao Chang, Marc DeMoya, George Velmahos
PURPOSE: To explore whether psoas cross sectional area (CSA) and density (Hounsfield Units, HU) are associated with nutritional adequacy and clinical outcomes in surgical intensive care unit patients. MATERIALS AND METHODS: Subjects with at least one CT scan within 72h of ICU admission were included. Demographic, nutritional, radiographic, and outcomes data were collected. Psoas muscle CSA and HU were assessed at the L4-L5 intervertebral disk level. Change (Δ) in CSA and HU overall and per day were calculated...
January 3, 2018: Journal of Critical Care
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