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https://www.readbyqxmd.com/read/28719063/enhanced-fibrinolysis-with-magnetically-powered-colloidal-microwheels
#1
Tonguc O Tasci, Dante Disharoon, Rogier M Schoeman, Kuldeepsinh Rana, Paco S Herson, David W M Marr, Keith B Neeves
Thrombi that occlude blood vessels can be resolved with fibrinolytic agents that degrade fibrin, the polymer that forms between and around platelets to provide mechanical stability. Fibrinolysis rates however are often constrained by transport-limited delivery to and penetration of fibrinolytics into the thrombus. Here, these limitations are overcome with colloidal microwheel (µwheel) assemblies functionalized with the fibrinolytic tissue-type plasminogen activator (tPA) that assemble, rotate, translate, and eventually disassemble via applied magnetic fields...
July 18, 2017: Small
https://www.readbyqxmd.com/read/28712269/acne-fulminans-following-isotretinoine-therapy
#2
Dario Didona, Giovanni Paolino, Carmen Cantisani, Giacomo Viti, Dante R Caposiena Caro, Biagio Didona
No abstract text is available yet for this article.
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28707833/-sarcoma-centres-a-necessary-tool-in-the-management-of-patients-and-for-research
#3
Stéphane Cherix, Frédéric Vauclair, Boris Morattel, Matthias Vautrin, Maurice Matter, Michael Montemurro, Antonia Digklia, Igor Letovanec, Patrick Omoumi, François Saucy, Michel Gonzalez, André-Dante Durham, Francesca Bosisio, Anja C Zyska Cherix, Hannes A Rudiger
Sarcomas are rare diseases, the treatment of which requires an appropriate technical plateform and a broad spectrum of multidisciplinary specialists. Many are initially treated by unplanned excision, and then referred to specialized centres. Secondary treatments may lead to higher complication rates and local recurrence, with lower functional outcome, life quality and possibly overall survival. In order to improve the accessibility for referral to a specialist centre, the coordination of clinical and research activities, and the quality of the management of sarcomas in general, Lausanne University Hospital (CHUV) has opened a Sarcoma centre on October 1st 2016...
December 14, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28700105/dante-s-inferno-canto-xxx-imaginary-or-real-liver-disease
#4
Luigi Roffi
This image (Figure 1) shows a glimpse of Hell (Divine Comedy), when Dante Alighieri encounters Master Adam (who, having counterfeited the Florentine money, was burned at the stake in Florence in 1281), and Sinon (who tricked the Trojans with the wooden horse filled with Achaean warriors). Master Adam, an Englishman (magistro Adam de Anglia) (1) has the shape of a lute, a rotting face, and an abdomen bloated by a disease called 'dropsy' ("…And one I saw, who like a lute were shaped / if he had only had his groin cut off / down in the region where a man is forked / The heavy dropsy which unmates the limbs / in such a way with ill-digested humor / that face and paunch no longer correspond…/ Divine Comedy, Inferno XXX, 49-54) (2)...
July 12, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28683335/accumulation-of-current-use-pesticides-cholinesterase-inhibition-and-reduced-body-condition-in-juvenile-one-sided-livebearer-fish-jenynsia-multidentata-from-the-agricultural-pampa-region-of-argentina
#5
Julie Céline Brodeur, Marisol Sanchez, Luciana Castro, Dante Emanuel Rojas, Diego Cristos, María Jimena Damonte, María Belén Poliserpi, María Florencia D'Andrea, Adrián Enrique Andriulo
The aim of this study was to characterize the level and nature of the pesticide contamination received by one-sided livebearer fish (Jenynsia multidentata) from a watercourse situated within the main agricultural region of Argentina, and to assess the effects of this contamination on fish health. Juvenile one-sided livebearer fish (Jenynsia multidentata) were collected in December 2011 and March 2012 from three sites along the Pergamino River. Pesticide contamination was characterized by extracting whole fish and analytically determining thirty different pesticide molecules...
June 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/28676050/reconstruction-of-the-microalga-nannochloropsis-salina-genome-scale-metabolic-model-with-applications-to-lipid-production
#6
Nicolás Loira, Sebastian Mendoza, María Paz Cortés, Natalia Rojas, Dante Travisany, Alex Di Genova, Natalia Gajardo, Nicole Ehrenfeld, Alejandro Maass
BACKGROUND: Nannochloropsis salina (= Eustigmatophyceae) is a marine microalga which has become a biotechnological target because of its high capacity to produce polyunsaturated fatty acids and triacylglycerols. It has been used as a source of biofuel, pigments and food supplements, like Omega 3. Only some Nannochloropsis species have been sequenced, but none of them benefit from a genome-scale metabolic model (GSMM), able to predict its metabolic capabilities. RESULTS: We present iNS934, the first GSMM for N...
July 4, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28675846/chronic-nonbacterial-osteomyelitis-involving-the-mandible-a-case-report
#7
Gabriele Bocchialini, Luca Ferrari, Manuela Rossini, Anna Bozzola, Dante Burlini
INTRODUCTION: Chronic nonbacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO), is a very rare condition of unknown aetiology. It is characterised by focal sterile inflammatory disease with prolonged, self-limiting and recurrent episodes. CASE PRESENTATION: We report the discovery of this very rare disease following a mandibular abscess in a 10-year-old female. We initially focus on the difference between the preoperative orthopantomography and the maxillofacial computed tomography and magnetic resonance images obtained, and then on the improvement of strategies for correct diagnosis and treatment of this disease...
June 15, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28673901/implications-of-american-college-of-cardiology-american-heart-association-acc-aha-cholesterol-guidelines-on-statin-underutilization-for-prevention-of-cardiovascular-disease-in-diabetes-mellitus-among-several-us-networks-of-community-health-centers
#8
Ehimare Akhabue, Sarah S Rittner, Joseph E Carroll, Phillip M Crawford, Lydia Dant, Reesa Laws, Michael C Leo, Jon Puro, Stephen D Persell
BACKGROUND: Little is known about statin underutilization among diabetes mellitus patients cared for in community health centers, which tend to serve socioeconomically disadvantaged populations. Implications of the American College of Cardiology/American Heart Association (ACC/AHA) guidelines on preexisting gaps in statin treatment in this population are unclear. METHODS AND RESULTS: We included 32 440 adults (45% male, 63% nonwhite, 29% uninsured/Medicaid) aged 40 to 75 years with diabetes mellitus who received care within 16 community health center groups in 11 states in the Community Health Applied Research Network during 2013...
July 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28670025/high-resolution-computed-tomography-findings-in-eight-patients-with-hantavirus-pulmonary-syndrome
#9
Diego de Lacerda Barbosa, Bruno Hochhegger, Arthur Soares Souza, Gláucia Zanetti, Dante Luiz Escuissato, Gustavo de Souza Portes Meirelles, Marcelo Buarque de Gusmão Funari, Edson Marchiori
OBJECTIVE: The purpose of this study was to describe the high-resolution computed tomography (HRCT) findings in patients with hantavirus pulmonary syndrome (HPS). MATERIALS AND METHODS: We retrospectively reviewed HRCT findings from eight cases of HPS. All patients were men, aged 19-70 (mean, 41.7) years. Diagnoses were established by serological test (enzyme-linked immunosorbent assay) in all patients. Two chest radiologists analyzed the images and reached decisions by consensus...
May 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28656646/parenteral-irons-versus-transfused-red-blood-cells-for-treatment-of-anemia-during-canine-experimental-bacterial-pneumonia
#10
Dante A Suffredini, Wanying Xu, Junfeng Sun, Jesús Barea-Mendoza, Steven B Solomon, Samuel L Brashears, Andreas Perlegas, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson, Irene Cortés-Puch
BACKGROUND: No studies have been performed comparing intravenous (IV) iron with transfused red blood cells (RBCs) for treating anemia during infection. In a previous report, transfused older RBCs increased free iron release and mortality in infected animals when compared to fresher cells. We hypothesized that treating anemia during infection with transfused fresh RBCs, with minimal free iron release, would prove superior to IV iron therapy. STUDY DESIGN AND METHODS: Purpose-bred beagles (n = 42) with experimental Staphylococcus aureus pneumonia rendered anemic were randomized to be transfused RBCs stored for 7 days or one of two IV iron preparations (7 mg/kg), iron sucrose, a widely used preparation, or ferumoxytol, a newer formulation that blunts circulating iron levels...
June 27, 2017: Transfusion
https://www.readbyqxmd.com/read/28654019/preventive-effect-of-cow-s-milk-fermented-with-lactobacillus-paracasei-cba-l74-on-common-infectious-diseases-in-children-a-multicenter-randomized-controlled-trial
#11
Giovanni Corsello, Maurizio Carta, Roberto Marinello, Marina Picca, Giulio De Marco, Maria Micillo, Dante Ferrara, Patrizia Vigneri, Gaetano Cecere, Pasqualina Ferri, Paola Roggero, Giorgio Bedogni, Fabio Mosca, Lorella Paparo, Rita Nocerino, Roberto Berni Canani
Background: Fermented foods have been proposed to prevent common infectious diseases (CIDs) in children attending day care or preschool. OBJECTIVES: To investigate the efficacy of dietary supplementation with cow's skim milk fermented with the probiotic Lactobacillus paracasei CBA L74 in reducing CIDs in children attending day care or preschool. Methods: Multicenter, randomized, double-blind, placebo-controlled trial on healthy children (aged 12-48 months) consuming daily 7 grams of cow's skim milk fermented with L...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28651924/medication-understanding-among-patients-living-with-multiple-chronic-conditions-implications-for-patient-reported-measures-of-adherence
#12
R J Fredericksen, L Gibbons, S Brown, T C Edwards, F M Yang, E Fitzsimmons, K Alperovitz-Bichell, M Godfrey, A Wang, A Church, C Gutierrez, E Paez, L Dant, S Loo, M Walcott, M J Mugavero, K Mayer, W C Mathews, D L Patrick, P K Crane, H M Crane
BACKGROUND: Low health literacy is associated with poor medication adherence and poor health outcomes. Limited understanding of prescribed medications may decrease validity of patient-reported adherence measures. OBJECTIVES: To assess knowledge of names and purposes of prescribed medications among patients with multiple chronic conditions. METHODS: Individual interviews were conducted with a convenience sample of patients from six U.S. primary care clinics...
June 20, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28649949/diagnostic-performance-of-a-lattice-boltzmann-based-method-for-fast-ct-fractional-flow-reserve
#13
Andreas Giannopoulos, Anji Tang, Yin Ge, Michael Cheezum, Michael Steigner, Shinichiro Fujimoto, Kanako Kumamaru, Dante Chiappino, Daniele Della Latta, Sergio Berti, Sara Chiappino, Frank Rybicki, Simone Melchionna, Dimitrios Mitsouras
AIMS: Fractional flow reserve (FFR) estimated from coronary computed tomography angiography (CT-FFR) offers non-invasive detection of lesion-specific ischemia. We developed and validated a fast CT-FFR algorithm utilizing the Lattice-Boltzmann Method for blood flow simulation (LBM CT-FFR). METHODS AND RESULTS: 64 patients from 3 institutions with clinically-indicated CTA and invasive FFR measurement were retrospectively analyzed. CT-FFR was performed using an on-site tool interfacing with a commercial Lattice-Boltzmann fluid dynamics cloud-based platform...
June 27, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28643670/-chronic-myelogenous-leukemia-monitoring-and-predictors-of-a-favorable-response-to-treatment-with-imatinib
#14
María J Mela Osorio, Isabel A Giere, Isolda Fernández, Miguel A Pavlovsky, Dante Intile, Carolina Pavlovsky
The expected five-year survival of chronic-phase chronic myeloid leukemia patients treated with tyrosine kinase inhibitors is over 90%. Little data is available regarding the results in the Argentinian population. This information might be of interest as generic imatinib is now available in the region. The aim of this study is to provide information on monitoring and the long-term treatment with imatinib outside of a controlled clinical trial, as well as to analyze the predictive effect of early responses to achieve molecular remission 4...
2017: Medicina
https://www.readbyqxmd.com/read/28641784/ultrasonographic-fatty-liver-indicator-detects-mild-steatosis-and-correlates-with-metabolic-histological-parameters-in-various-liver-diseases
#15
Stefano Ballestri, Fabio Nascimbeni, Enrica Baldelli, Alessandra Marrazzo, Dante Romagnoli, Giovanni Targher, Amedeo Lonardo
BACKGROUND AND AIMS: Fatty liver is a common feature of different types of liver diseases. The sensitivity and specificity of ultrasonography for diagnosing fatty liver are variable. A semi-quantitative ultrasound score, i.e., the ultrasonographic fatty liver indicator (US-FLI), is closely associated with metabolic/histological variables in patients with nonalcoholic fatty liver disease (NAFLD). The main aims of this study were to assess the diagnostic performance of US-FLI in detecting varying degrees of histological steatosis, and to examine the association of US-FLI with metabolic/histological parameters in 352 biopsied patients with various chronic liver diseases (173 with hepatitis C [HCV], 23 with hepatitis B [HBV], 123 with NAFLD and 33 with other etiologies)...
July 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28632825/-what-do-the-numbers-tell-us-about-the-temporal-evolution-of-chagas-disease
#16
Mauricio Canals, Christian González, Lucia Canals, Andrea Canals, Dante Cáceres, Sergio Alvarado, Pedro E Cattan, Miguel Saavedra, Inés Zulantay, Werner Apt
Chagas disease remains highly prevalent in Chile, especially between the regions of Arica and Parinacota, and Coquimbo. Since 1999 it is considered that in Chile the vector transmission was interrupted. Under this premise, the epidemiological dynamics should be changing. We analyzed the evolution of the prevalence of Chagas' disease analyzing 64,995 xenodiagnosis performed in the laboratory of Parasitology of the Faculty of Medicine of the University of Chile between 1949 and 2014. The evolution of the mortalities and incidences from the databases of the Ministry of Health in the periods in which it was analyzed...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28631281/detecting-large-scale-networks-in-the-human-brain-using-high-density-electroencephalography
#17
Quanying Liu, Seyedehrezvan Farahibozorg, Camillo Porcaro, Nicole Wenderoth, Dante Mantini
High-density electroencephalography (hdEEG) is an emerging brain imaging technique that can be used to investigate fast dynamics of electrical activity in the healthy and the diseased human brain. Its applications are however currently limited by a number of methodological issues, among which the difficulty in obtaining accurate source localizations. In particular, these issues have so far prevented EEG studies from reporting brain networks similar to those previously detected by functional magnetic resonance imaging (fMRI)...
June 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28622188/differences-in-fundamental-sagittal-pelvic-parameters-based-on-age-sex-and-race
#18
Robert K Merrill, Jun S Kim, Dante M Leven, Joung Heon Kim, Joshua J Meaike, Rachel S Bronheim, Kelly I Suchman, Doug Nowacki, Sunder S Gidumal, Samuel K Cho
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To determine whether age, sex, and race have independent effects on sagittal pelvic parameters. SUMMARY OF BACKGROUND DATA: Pelvic parameters and sagittal balance correlate with health-related quality of life and are important for patient assessment and surgical planning. Age, sex, and race are 3 unalterable patient factors that may influence pelvic morphology. METHODS: We conducted a retrospective review of consecutive adult patients who presented to our radiology practice between 2010 and 2015 and had a standing, lateral lumbosacral radiograph...
June 15, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28618920/castor-oil-for-induction-of-labour-a-retrospective-study
#19
Isabella Neri, Giulia Dante, Lucrezia Pignatti, Chiara Salvioli, Fabio Facchinetti
PURPOSE: The aim of this study is to investigate the safety and efficacy of castor oil to induce labour. MATERIALS AND METHODS: A retrospective observational case control study was conducted over five years. Castor oil was proposed to women referred to the Birth Centre (Castor Oil group (COG)). They were compared to women who chose to be followed by the traditional doctor-led unit (control group (CG)). Castor oil was administered in a 60 ml single dose in 200 ml of warm water...
June 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28616075/proximity-ligation-scaffolding-and-comparison-of-two-trichoderma-reesei-strains-genomes
#20
Etienne Jourdier, Lyam Baudry, Dante Poggi-Parodi, Yoan Vicq, Romain Koszul, Antoine Margeot, Martial Marbouty, Frédérique Bidard
BACKGROUND: The presence of low complexity and repeated regions in genomes often results in difficulties to assemble sequencing data into full chromosomes. However, the availability of full genome scaffolds is essential to several investigations, regarding for instance the evolution of entire clades, the analysis of chromosome rearrangements, and is pivotal to sexual crossing studies. In non-conventional but industrially relevant model organisms, such as the ascomycete Trichoderma reesei, a complete genome assembly is seldom available...
2017: Biotechnology for Biofuels
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