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https://www.readbyqxmd.com/read/29027888/same-hospital-re-admission-rate-is-not-reliable-for-measuring-post-operative-infection-related-re-admission
#1
Rishi Rattan, Joshua Parreco, Tanya L Zakrison, D Dante Yeh, Howard M Lieberman, Nicholas Namias
BACKGROUND: Post-operative infections cause morbidity, consume resources, and are an important quality measure in assessing and comparing hospitals. Commonly used metrics do not account for re-admission to a different hospital. The Nationwide Readmissions Database (NRD) tracks re-admissions across United States (US) hospitals. Infection-related re-admission across US hospitals has not been studied previously. PATIENTS AND METHODS: The 2013 NRD was queried for admissions with a primary International Classification of Diseases and Related Health Problems, 9th revision, Clinical Modification code for the most frequently performed operations...
October 13, 2017: Surgical Infections
https://www.readbyqxmd.com/read/29024792/effective-connectivity-inferred-from-fmri-transition-dynamics-during-movie-viewing-points-to-a-balanced-reconfiguration-of-cortical-interactions
#2
REVIEW
Matthieu Gilson, Gustavo Deco, Karl Friston, Patric Hagmann, Dante Mantini, Viviana Betti, Gian Luca Romani, Maurizio Corbetta
Our behavior entails a flexible and context-sensitive interplay between brain areas to integrate information according to goal-directed requirements. However, the neural mechanisms governing the entrainment of functionally specialized brain areas remain poorly understood. In particular, the question arises whether observed changes in the regional activity for different cognitive conditions are explained by modifications of the inputs to the brain or its connectivity? We observe that transitions of fMRI activity between areas convey information about the tasks performed by 19 subjects, watching a movie versus a black screen (rest)...
October 9, 2017: NeuroImage
https://www.readbyqxmd.com/read/28993672/oligomerization-primed-coiled-coil-domain-interaction-with-ubc13-confers-processivity-to-traf6-ubiquitin-ligase-activity
#3
Lin Hu, Jiafeng Xu, Xiaomei Xie, Yiwen Zhou, Panfeng Tao, Haidong Li, Xu Han, Chong Wang, Jian Liu, Pinglong Xu, Dante Neculai, Zongping Xia
Ubiquitin ligase TRAF6, together with ubiquitin-conjugating enzyme Ubc13/Uev1, catalyzes processive assembly of unanchored K63-linked polyubiquitin chains for TAK1 activation in the IL-1R/TLR pathways. However, what domain and how it functions to enable TRAF6's processivity are largely uncharacterized. Here, we find TRAF6 coiled-coil (CC) domain is crucial to enable its processivity. The CC domain mediates TRAF6 oligomerization to ensure efficient long polyubiquitin chain assembly. Mutating or deleting the CC domain impairs TRAF6 oligomerization and processive polyubiquitin chain assembly...
October 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28992948/the-potential-of-real-time-fmri-neurofeedback-for-stroke-rehabilitation-a-systematic-review
#4
Tianlu Wang, Dante Mantini, Celine R Gillebert
Real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback aids the modulation of neural functions by training self-regulation of brain activity through operant conditioning. This technique has been applied to treat several neurodevelopmental and neuropsychiatric disorders, but its effectiveness for stroke rehabilitation has not been examined yet. Here, we systematically review the effectiveness of rt-fMRI neurofeedback training in modulating motor and cognitive processes that are often impaired after stroke...
September 18, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28991316/-epidemiological-characterization-of-bites-on-people-as-emergency-care-record-province-of-los-andes-chile
#5
Vania Villagra, Dante Cáceres, Sergio Alvarado, Elizabeth Salinas, M Loreto Caldera, Erick Lucero, Paola Viviani, Marisa Torres
BACKGROUND: Bites constitute a public health problem worldwide. AIM: To characterize epidemiologically bites by animals happened in the province of Los Andes (2005-2007). METHOD: Descriptive, retrospective epidemiological study. Studied variables: Bitten person (BP), accident by bite, biting animal and bite. It was not feasible to obtain more updated information by law of patient protection. RESULTS: 2,360 BP were assisted in the emergency unit of San Juan de Dios Hospital and Rio Blanco clinic...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28991289/actividad-f%C3%A3-sica-y-su-asociaci%C3%A3-n-con-enfermedades-cr%C3%A3-nicas-en-ancianos-de-11-ciudades-del-per%C3%A3%C2%BA
#6
Christian R Mejia, Araseli Verastegui-Díaz, Dante M Quiñones-Laveriano, Germán Aranzabal-Alegría, Virgilio E Failoc-Rojas
Objetivo: Determinar la frecuencia de actividad física y su asociación con enfermedades crónicas en ancianos de 11 ciudades del Perú. Métodos: Se realizó un estudio transversal analítico de datos secundarios. La variable dependiente fue la no realización de actividad física, y las independientes fueron las enfermedades crónicas y otras variables fisioantropométricas. Para el análisis bivariado y multivariado se usaron los modelos lineales generalizados...
2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28983307/qtl-mapping-by-whole-genome-re-sequencing-and-analysis-of-candidate-genes-for-nitrogen-use-efficiency-in-rice
#7
Xinghai Yang, Xiuzhong Xia, Zongqiong Zhang, Baoxuan Nong, Yu Zeng, Faqian Xiong, Yanyan Wu, Ju Gao, Guofu Deng, Danting Li
Nitrogen is a major nutritional element in rice production. However, excessive application of nitrogen fertilizer has caused severe environmental pollution. Therefore, development of rice varieties with improved nitrogen use efficiency (NUE) is urgent for sustainable agriculture. In this study, bulked segregant analysis (BSA) combined with whole genome re-sequencing (WGS) technology was applied to finely map quantitative trait loci (QTL) for NUE. A key QTL, designated as qNUE6 was identified on chromosome 6 and further validated by Insertion/Deletion (InDel) marker-based substitutional mapping in recombinants from F2 population (NIL-13B4 × GH998)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28979118/gastrin-releasing-peptide-receptor-targeted-gadolinium-oxide-based-multifunctional-nanoparticles-for-dual-magnetic-resonance-fluorescent-molecular-imaging-of-prostate-cancer
#8
Danting Cui, Xiaodan Lu, Chenggong Yan, Xiang Liu, Meirong Hou, Qi Xia, Yikai Xu, Ruiyuan Liu
Bombesin (BBN), an analog of gastrin-releasing peptide (GRP), specifically binds to GRP receptors, which are overexpressed in human prostate cancer (PC). Here, we synthesized a BBN-modified gadolinium oxide (Gd2O3) nanoprobe containing fluorescein (Gd2O3-5(6)-carboxyfluorescein [FI]-polyethylene glycol [PEG]-BBN) for targeted magnetic resonance (MR)/optical dual-modality imaging of PC. The Gd2O3-FI-PEG-BBN nanoparticles exhibited a relatively uniform particle size with an average diameter of 52.3 nm and spherical morphology as depicted by transmission electron microscopy...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28958875/investigation-of-3d-reduced-field-of-view-carotid-atherosclerotic-plaque-imaging
#9
Xueyan Xu, Hai Geng, Qiang Zhang, Jianmin Yu, Yujing Chu, Guang Dong, Jun Wu
To investigate the feasibility of using CUBE based reduced field of view imaging in atherosclerotic plaque imaging. Twenty-four patients were enrolled in this prospective study (13 males, 11 females, age 63±10). All patients underwent MRI exams consisting of 3D TOF, MPRAGE, iMSDE, DANTE, full FOV and reduced FOV CUBE imaging; 18 patients under went contrast enhanced imaging. The resulting images from different imaging sequences were assessed in terms of blood suppression, SNR, motion artifacts and vascular clarity...
September 25, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28952059/a-need-for-biology-driven-personalized-radiotherapy-in-breast-cancer
#10
Pelagia G Tsoutsou, André-Dante Durham, Marie-Catherine Vozenin
No abstract text is available yet for this article.
September 27, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28940975/silver-makes-better-electrical-contacts-to-thiol-terminated-silanes-than-gold
#11
Haixing Li, Timothy Su, María Camarasa-Gómez, Daniel Hernangómez-Pérez, Simon Henn, Vladislav Pokorný, Caravaggio Dante Caniglia, Michael Inkpen, Richard Korytár, Michael Steigerwald, Colin Nuckolls, Ferdinand Evers, Latha Venkataraman
We report that the single molecule junction conductance of thiol-terminated silanes with Ag electrodes are higher than the conductance of those formed with Au electrodes. These results are in contrast to the trends in the metal work function Φ(Ag) < Φ(Au). As such, one would expect a better alignment of the Au Fermi level to the molecular orbital of silane that mediates charge transport. Additionally, this conductance trend is reversed when we replace the thiols with amines, highlighting the impact of metal-S covalent and metal-NH2 dative bonds in controlling the molecular conductance...
September 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28937444/methylene-blue-for-bronchopleural-fistula-localization
#12
Kenneth K Sakata, Faria Nasim, Dante N Schiavo, Darlene R Nelson, Ryan M Kern, John J Mullon
A bronchopleural fistula (BPF) is a communication between the pleural space and the bronchial tree. BPFs are challenging to diagnose and are associated with a high morbidity and mortality. Sequential balloon occlusion is commonly used for localization of a BPF. We describe our experience with 4 cases of successful localization of the BPF by instillation of methylene blue into the pleural space through a pigtail catheter, with simultaneous bronchoscopic visualization of dye in the tracheobronchial tree. Two patients were treated with endobronchial valves and 3 had a surgical thoracic muscle flap placed...
September 20, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28934406/-%C3%A2-and-now-what-to-do-direct-surgical-trans-atrial-endocardial-pacing-electrode-implantation-in-a-very-complex-situation
#13
Andrea Rossi, Alberto Clemente, Dante Chiappino, Michele Emdin, Marcello Piacenti
No abstract text is available yet for this article.
September 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28925873/silver-nanoparticles-with-high-loading-capacity-of-amphotericin-b-characterization-bactericidal-and-antifungal-effects
#14
Victoria Leonhard, Roxana Valeria Alasino, Adrián Muñoz, Dante Miguel Beltramo
The purpose of this study was to evaluate the most appropriate conditions to generate silver nanoparticles (AgNPs) loaded with a potent antimycotic drug like amphotericin B (AmB), characterize the physicochemical properties, and also evaluate the cytotoxic effect and biological activity of these new nanostructures as a potential nanocarrier for hydrophobic drugs. It was determined that the optimal molar ratio between Ag and AmB is 1/1 given the uniformity of size around 1750 nm of the nanoparticles generated as well as their strongly negative ζ potential of -27 mV, a condition that favors repulsions between AgNPs and inhibiting their aggregation...
September 18, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28924334/from-the-cradle-to-the-grave-the-effect-of-adverse-caregiving-environments-on-attachment-and-relationships-throughout-the-lifespan
#15
Colleen Doyle, Dante Cicchetti
This paper reviews research examining the effects of adverse early caregiving on relationships throughout the lifespan. Central attachment constructs are summarized and integrated into a review of research on the long-term effects of institutional rearing and child maltreatment. Findings are interpreted within the organizational perspective on development, which conceptualizes attachment as a stage-salient task of infancy that influences the reorganization of adaptive/maladaptive functioning around subsequent stage-salient tasks...
June 2017: Clinical Psychology
https://www.readbyqxmd.com/read/28922206/hidden-costs-of-hospitalization-after-firearm-injury-national-analysis-of-different-hospital-readmission
#16
Rishi Rattan, Joshua Parreco, Nicholas Namias, Gerd D Pust, D Dante Yeh, Tanya L Zakrison
OBJECTIVE: To compare the risk factors and costs associated with readmission after firearm injury nationally, including different hospitals. BACKGROUND: No national studies capture readmission to different hospitals after firearm injury. METHODS: The 2013 to 2014 Nationwide Readmissions Database was queried for patients admitted after firearm injury. Logistic regression identified risk factors for 30-day same and different hospital readmission...
September 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28917822/chemgenie-integration-of-chemogenomics-data-for-applications-in-chemical-biology
#17
REVIEW
Peter S Kutchukian, Charlie Chang, Sean J Fox, Erica Cook, Richard Barnard, David Tellers, Huijun Wang, Dante Pertusi, Meir Glick, Robert P Sheridan, Iain M Wallace, Anne Mai Wassermann
Increasing amounts of biological data are accumulating in the pharmaceutical industry and academic institutions. However, data does not equal actionable information, and guidelines for appropriate data capture, harmonization, integration, mining, and visualization need to be established to fully harness its potential. Here, we describe ongoing efforts at Merck & Co. to structure data in the area of chemogenomics. We are integrating complementary data from both internal and external data sources into one chemogenomics database (Chemical Genetic Interaction Enterprise; CHEMGENIE)...
September 14, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28906131/effects-of-immunomodulators-on-the-response-induced-by-vaccines-against-autoimmune-diseases
#18
Dante J Marciani
A promising treatment for T-cell-mediated autoimmune diseases is the induction of immune tolerance by modulating the immune response against self-antigens, an objective that may be achieved by vaccination. There are two main types of vaccines currently under development. The tolerogenic vaccines, composed of proteins formed by a cytokine fused to a self-antigen, which usually induce tolerance by eliminating the T-cells that are immune reactive against the self-antigen. The immunogenic vaccines, comprised of a self-antigen plus a sole Th2 adjuvant either free or conjugated, that alleviate autoimmunity by switching the immune response against the self-antigen, from a damaging pro-inflammatory Th1/Th17 to an anti-inflammatory Th2 immunity...
September 14, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28903154/incidence-and-trends-of-sepsis-in-us-hospitals-using-clinical-vs-claims-data-2009-2014
#19
Chanu Rhee, Raymund Dantes, Lauren Epstein, David J Murphy, Christopher W Seymour, Theodore J Iwashyna, Sameer S Kadri, Derek C Angus, Robert L Danner, Anthony E Fiore, John A Jernigan, Greg S Martin, Edward Septimus, David K Warren, Anita Karcz, Christina Chan, John T Menchaca, Rui Wang, Susan Gruber, Michael Klompas
Importance: Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time. Objective: To estimate the US national incidence of sepsis and trends using detailed clinical data from the electronic health record (EHR) systems of diverse hospitals. Design, Setting, and Population: Retrospective cohort study of adult patients admitted to 409 academic, community, and federal hospitals from 2009-2014...
October 3, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28899452/lc-hrms-for-characterizing-durum-wheat-pasta-production-variability-and-consumer-overall-liking
#20
Francesca Lambertini, Daniele Cavanna, Dante Catellani, Mario Li Vigni, Caterina Durante, Alessandro D'Alessandro, Michele Suman
Semolina pasta represents one of the most important dishes in Italian cuisine worldwide. Italy is the leader in its production and, recently, the worldwide diffusion of its production has begun to grow tremendously. The perceived quality of a food product, such as pasta, is a key feature that allows a company to increase and maintain the competitive advantage of a specific brand. The overall flavor perception of the consumer, therefore, has become as important as other key quality factors such as texture and color; thus, the food industry needs to meet consumer expectations and needs the tools to objectively "measure" the quality of food products...
September 12, 2017: Journal of AOAC International
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