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https://www.readbyqxmd.com/read/28912311/draft-genome-sequence-of-the-human-pathogenic-fungus-scedosporium-boydii
#1
Ludovic Duvaux, Jason Shiller, Patrick Vandeputte, Thomas Dugé de Bernonville, Christopher Thornton, Nicolas Papon, Bruno Le Cam, Jean-Philippe Bouchara, Amandine Gastebois
The opportunistic fungal pathogen Scedosporium boydii is the most common Scedosporium species in French patients with cystic fibrosis. Here we present the first genome report for S. boydii, providing a resource which may enable the elucidation of the pathogenic mechanisms in this species.
September 14, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28868050/biofilm-formation-by-pseudallescheria-scedosporium-species-a-comparative-study
#2
Rodrigo Rollin-Pinheiro, Jardel V de Meirelles, Taissa V M Vila, Beatriz B Fonseca, Vinicius Alves, Susana Frases, Sonia Rozental, Eliana Barreto-Bergter
Pseudallescheria/Scedosporium species are medically important fungi that are present in soil and human impacted areas and capable of causing a wide spectrum of diseases in humans. Although little is known about their pathogenesis, their growth process and infection routes are very similar to those of Aspergillus species, which grow as biofilms in invasive infections. All nine strains tested here displayed the ability to grow as biofilms in vitro and to produce a dense network of interconnected hyphae on both polystyrene and the surfaces of central venous catheters, but with different characteristics...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28864936/a-case-of-cutaneous-mycosis-caused-by-scedosporium-dehoogii-on-an-immunocompromised-patient
#3
Yuichi Sakata, Fumiaki Taga, Tsuyoshi Ushigami, Kiminobu Takeda, Kazushi Anzawa, Akiko Nishibu, Takashi Mochizuki
This report describes a 77-year-old man with cutaneous mycosis caused by Scedosporium dehoogii while taking oral betamethasone and tacrolimus for the treatment of rheumatoid arthritis. At examination in our clinic, the patient had multiple cystic lesions and nodules with slight tenderness, varying in size up to 4 cm, on his left knee and shin. He had not noticed any traumatic injury at the site of the lesions. Fungal cultures of samples taken from the abscesses, scales, and crusts of the lesions yielded white, later grayish brown, fluffy surfaced colonies...
September 1, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28864921/invasive-pulmonary-fungal-infections-in-cystic-fibrosis
#4
Carsten Schwarz, Claudia Brandt, Paul Whitaker, Sivagurunathan Sutharsan, Heino Skopnik, Silvia Gartner, Christina Smazny, Jobst F Röhmel
Invasive pulmonary mycosis is after allergic bronchopulmonary aspergillosis (ABPA) a frequent and severe complication of CF lung disease. Among CF caregivers, there is an insecurity when and how to treat infections of the lung parenchyma caused by different fungi in patients with CF. This case series provides a multicenter experience on diagnostic, manifestation, and treatment of non-ABPA cases of pulmonary. Non-ABPA cases of pulmonary mycoses in patients with CF have been collected from the CF Centers in Berlin, Essen, Worms, Frankfurt (Germany), Leeds (UK), and Barcelona (Spain)...
September 1, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28837349/amino-acid-directed-strategy-for-inducing-the-marine-derived-fungus-scedosporium-apiospermum-f41-1-to-maximize-alkaloid-diversity
#5
Li-Hong Huang, Meng-Yang Xu, Hou-Jin Li, Jin-Qian Li, Yan-Xiu Chen, Wen-Zhe Ma, Yi-Ping Li, Jun Xu, De-Po Yang, Wen-Jian Lan
By feeding various amino acids to the marine fungus Scedosporium apiospermum F41-1, 22 diverse alkaloids, including 14 new compounds, were obtained. Scedapins A-E (1-5) possess a rare skeleton of a pyrazinoquinazolinedione and an imidazoindolone/indolone linked by a tetrahydrofuran ring. Scedapin C (3) is the first example of fumiquinazoline that contains an aminosulfonyl group. Their structures were determined by HRMS, NMR, ECD calculations and X-ray single-crystal diffraction analysis. The biosynthetic pathways of fumiquinazolines 1-18 were proposed...
August 24, 2017: Organic Letters
https://www.readbyqxmd.com/read/28836110/effects-of-photodynamic-therapy-on-the-growth-and-antifungal-susceptibility-of-scedosporium-and-lomentospora-spp
#6
Qiaoyun Lu, Yi Sun, Dingdan Tian, Shoubao Xiang, Lujuan Gao
Scedosporium and Lomentospora species are the second most frequent colonizing, allergenic, or invasive fungal pathogens in patients with cystic fibrosis, and are responsible for infections varying from cutaneous and subcutaneous tissue infections caused by traumatic inoculation to severe systemic diseases in immunocompromised patients. The clinical relevance of fungal airway colonization for individual patients harboring Scedosporium and Lomentospora species is still an underestimated issue. The high resistance of Scedosporium and Lomentospora species to antifungal drugs has highlighted the need for alternative treatment modalities, and antimicrobial photodynamic therapy may be one such alternative...
August 23, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28762125/progress-in-definition-prevention-and-treatment-of-fungal-infections-in-cystic-fibrosis
#7
REVIEW
Carsten Schwarz, Dominik Hartl, Olaf Eickmeier, Andreas Hector, Christian Benden, Isabelle Durieu, Amparo Sole, Silvia Gartner, Carlos E Milla, Peter James Barry
Cystic fibrosis (CF) is a chronic lethal multi-system condition; however, most of the morbidity and mortality is dependent on the status of the respiratory system. Progressive respiratory decline is mediated by chronic infection and inflammation, punctuated by important acute events known as pulmonary exacerbations which can lead to accelerated decline. The main bacterial species causing infections include Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus influenzae and Achromobacter xylosoxidans. In addition to bacteria, fungi are detected in a significant number of patients...
July 31, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28748285/toward-the-standardization-of-mycological-examination-of-sputum-samples-in-cystic-fibrosis-results-from-a-french-multicenter-prospective-study
#8
Noémie Coron, Marc Pihet, Emilie Fréalle, Yolande Lemeille, Claudine Pinel, Hervé Pelloux, Gilles Gargala, Loic Favennec, Isabelle Accoceberry, Isabelle Durand-Joly, Frédéric Dalle, Frédéric Huet, Annlyse Fanton, Amale Boldron, Guy-André Loeuille, Philippe Domblides, Bérengère Coltey, Isabelle Pin, Catherine Llerena, Françoise Troussier, Christine Person, Christophe Marguet, Nathalie Wizla, Caroline Thumerelle, Dominique Turck, Stéphanie Bui, Michael Fayon, Alain Duhamel, Anne Prévotat, Benoit Wallaert, Sylvie Leroy, Jean-Philippe Bouchara, Laurence Delhaes
Fungal respiratory colonization of cystic fibrosis (CF) patients emerges as a new concern; however, the heterogeneity of mycological protocols limits investigations. We first aimed at setting up an efficient standardized protocol for mycological analysis of CF sputa that was assessed during a prospective, multicenter study: "MucoFong" program (PHRC-06/1902). Sputa from 243 CF patients from seven centers in France were collected over a 15-month period and submitted to a standardized protocol based on 6 semi-selective media...
July 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28705674/molecular-bases-of-antifungal-resistance-in-filamentous-fungi
#9
Cheshta Sharma, Anuradha Chowdhary
Invasive mould infections due to Aspergillus species, Fusarium spp., Scedosporium spp. and other filamentous fungi remain a significant cause of morbidity and mortality in immunocompromised patients. Antifungal therapy is required for successful patient management; however, limited antifungal drugs and emergence of drug resistance pose a challenge to the clinicians for the effective management of the disease. The evolution of multidrug resistant strains due to selective pressure and the intrinsically resistant pathogenic species are a major concern...
July 10, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28704511/genetic-variation-analysis-and-relationships-among-environmental-strains-of-scedosporium-apiospermum-sensu-stricto-in-bangkok-thailand
#10
Thanwa Wongsuk, Potjaman Pumeesat, Natthanej Luplertlop
The Scedosporium apiospermum species complex is an emerging filamentous fungi that has been isolated from environment. It can cause a wide range of infections in both immunocompetent and immunocompromised individuals. We aimed to study the genetic variation and relationships between 48 strains of S. apiospermum sensu stricto isolated from soil in Bangkok, Thailand. For PCR, sequencing and phylogenetic analysis, we used the following genes: actin; calmodulin exons 3 and 4; the second largest subunit of the RNA polymerase II; ß-tubulin exon 2-4; manganese superoxide dismutase; internal transcribed spacer; transcription elongation factor 1α; and beta-tubulin exons 5 and 6...
2017: PloS One
https://www.readbyqxmd.com/read/28699395/scedosporium-apiospermum-infection-lethal-complication-after-extracorporeal-cardiopulmonary-resuscitation
#11
Yong Mei, Xufeng Chen, Kai Sun, Jinru Lv, Hao Sun, Jinsong Zhang
In recent years, the development of extracorporeal membrane oxygenation (ECMO) technology has led to its extensive use in clinical practice. In particular, ECMO can play an important role in cardiopulmonary resuscitation (CPR). The American Heart Association CPR guidelines recommend its use in patients with cardiac arrest due to reversible disorders, along with high-quality CPR. This is called extracorporeal cardiopulmonary resuscitation (ECPR). However, it is important to be aware of the possibility of infection-related complications...
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28669833/pathobiology-of-lomentospora-prolificans-could-this-species-serve-as-a-model-of-primary-antifungal-resistance
#12
Aize Pellon, Andoni Ramirez-Garcia, Idoia Buldain, Aitziber Antoran, Leire Martin-Souto, Aitor Rementeria, Fernando L Hernando
The number of fungal isolates resistant to antifungal drugs has increased dramatically over the last few years and has become an important concern for clinicians. Among these isolates, fungi showing multidrug resistance are especially worrying because of the difficulties associated with their treatment. These factors hamper the successful recovery of patients and drastically raise mortality rates. Therefore, since it is well known that antifungal resistance is multifactorial and several mechanisms in different fungi have been described, there is a need to study these processes in depth...
June 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28649485/scedosporium-apiospermum-brain-abscesses-in-a-patient-after-near-drowning-a-case-report-with-10-year-follow-up-and-a-review-of-the-literature
#13
Sandra C Signore, Christoph P Dohm, Gunther Schütze, Mathias Bähr, Pawel Kermer
Scedosporium apiospermum is known to be a fungal pathogen affecting immunocompromised as well as non-immunodeficient patients. Although this fungus is found rarely, an infection can lead to severe and even fatal disease. Here, we describe the case of a 41-year-old female who developed multiple Scedosporium apiospermum brain abscesses after near-drowning with aspiration of contaminated mud and water. She showed various neurological symptoms. The patient recovered after removal of abscesses in combination with long-term antifungal treatment...
September 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28639066/enzymatic-mechanisms-involved-in-evasion-of-fungi-to-the-oxidative-stress-focus-on-scedosporium-apiospermum
#14
C Staerck, P Vandeputte, A Gastebois, A Calenda, S Giraud, N Papon, J P Bouchara, M J J Fleury
The airways of patients with cystic fibrosis (CF) are frequently colonized by various filamentous fungi, mainly Aspergillus fumigatus and Scedosporium species. To establish within the respiratory tract and cause an infection, these opportunistic fungi express pathogenic factors allowing adherence to the host tissues, uptake of extracellular iron, or evasion to the host immune response. During the colonization process, inhaled conidia and the subsequent hyphae are exposed to reactive oxygen species (ROS) and reactive nitrogen species (RNS) released by phagocytic cells, which cause in the fungal cells an oxidative stress and a nitrosative stress, respectively...
June 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28618155/clinical-outcome-of-cystic-fibrosis-patients-colonized-by-scedosporium-species-following-lung-transplantation-a-single-center-15-year-experience
#15
Perrine Parize, Veronique Boussaud, Vianney Poinsignon, Emilie Sitterlé, Francoise Botterel, Sandrine Lefeuvre, Romain Guillemain, Eric Dannaoui, Eliane M Billaud
BACKGROUND: Fungi of the genus Scedosporium are emerging pathogens responsible for severe infections in lung transplant recipients. These infections are associated with poor prognosis and some centers consider now Scedosporium species colonization as a contraindication to lung transplantation (LT) even though no published evidence demonstrates that Scedosporium species colonization is associated with higher morbidity or mortality after LT. METHODS: Here, we aim to describe characteristics and outcome of cystic fibrosis (CF) lung transplant recipients colonized with Scedosporium species in a single center over a 15-year period...
June 15, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28609568/ultrasonography-of-a-ureteral-and-bladder-fungal-granuloma-caused-by-scedosporium-apiospermum-in-a-basset-hound
#16
Jaya Kochenburger, Christian Eriksson, Marc Greenberg, Laura Hoyt
A 5-year-old, spayed female, Basset Hound was referred for evaluation of a urinary bladder mass. Ultrasonographic images revealed a large, inhomogeneous, hypoechoic mass associated with the dorsal wall of the neck of the urinary bladder and left ureter. Partial cystectomy and left ureteral reimplantation were performed. Histopathology showed a severe inflammatory mass lesion forming multiple granulomas. A DNA sequencing test revealed Scedosporium apiospermum as the causative agent. Susceptibility tests on the isolated strain indicated susceptibility to voriconazole...
June 13, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28538200/fungi-diversity-from-different-depths-and-times-in-chicken-manure-waste-static-aerobic-composting
#17
Wenjie Gu, Yusheng Lu, Zhiyuan Tan, Peizhi Xu, Kaizhi Xie, Xia Li, Lili Sun
The Dirichlet multinomial mixtures mode was used to analyse illumina sequencing data to reveal both temporal and spatial variations of the fungi community present in the aerobic composting. Results showed that 670 operational taxonomic units (OTUs) were detected, and the dominant phylum was Ascomycota. There were four types of samples fungi communities during the composting process. Samples from the early composting stage were mainly grouped into type I and Saccharomycetales sp. was dominant. Fungi community in the medium composting stage were fallen into type II and III, Sordariales sp...
September 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28512704/pseudomonas-aeruginosa-inhibits-the-growth-of-scedosporium-and-lomentospora-in-vitro
#18
Sharon C-A Chen, Shilpa Patel, Wieland Meyer, Belinda Chapman, Hong Yu, Karen Byth, Peter G Middleton, Helena Nevalainen, Tania C Sorrell
In vitro bacterial-fungal interaction studies in cystic fibrosis (CF) have mainly focused on interactions between bacteria and Candida. Here we investigated the effect of Pseudomonas aeruginosa on the growth of Scedosporium/Lomentospora spp. Standard suspensions of P. aeruginosa (16 non-mucoid and nine mucoid isolates) were dropped onto paper disks, placed on lawns of Lomentospora prolificans (formerly Scedosporium prolificans) strain WM 14.140 or Scedosporium aurantiacum strain WM 11.78 on solid agar. The median inhibitory activity (mIz) was calculated for each fungal-bacterial combination...
May 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28504471/scedosporium-apiospermum-complex-in-cystic-fibrosis-should-we-treat
#19
Maria Noni, Anna Katelari, Aikaterini Kapi, Angeliki Stathi, George Dimopoulos, Stavros-Eleftherios Doudounakis
Species of the Scedosporium apiospermum complex are the second most frequent filamentous fungi after Aspergillus fumigatus that can be found in cystic fibrosis (CF). Mixed colonisation by S. apiospermum complex and A. fumigatus is also quite common. In this study we summarise all CF patients who were colonised by S. apiospermum complex during their childhood and we present two CF patients who were treated as fungal bronchitis due to S. apiospermum complex. The medical records of 400 CF patients were reviewed in order to identify those with positive respiratory cultures for S...
September 2017: Mycoses
https://www.readbyqxmd.com/read/28490578/investigating-clinical-issues-by-genotyping-of-medically-important-fungi-why-and-how
#20
REVIEW
Alexandre Alanio, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Stéphane Bretagne
Genotyping studies of medically important fungi have addressed elucidation of outbreaks, nosocomial transmissions, infection routes, and genotype-phenotype correlations, of which secondary resistance has been most intensively investigated. Two methods have emerged because of their high discriminatory power and reproducibility: multilocus sequence typing (MLST) and microsatellite length polymorphism (MLP) using short tandem repeat (STR) markers. MLST relies on single-nucleotide polymorphisms within the coding regions of housekeeping genes...
July 2017: Clinical Microbiology Reviews
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