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https://www.readbyqxmd.com/read/29324504/aspergillus-and-other-respiratory-fungal-infections-in-the-icu-diagnosis-and-management
#1
José-Artur Paiva, Paulo Mergulhão, José Manuel Pereira
PURPOSE OF REVIEW: Filamentous fungi respiratory infections, namely because of Aspergillus, Mucorales, Fusarium, or Scedosporium, show rising incidence and occur more in populations which are not classically immunosuppressed. This and their persistent dismal prognosis are the focus of this review. RECENT FINDINGS: Both an early diagnosis, rooted on a high level of suspicion and based on clinical picture, radiology, cultural microbiological exams, fungal biomarkers, PCR and biopsy, and an early therapy, including immunorecovery, whenever possible, good antifungal selection, and surgery for source control, are paramount to maximize the outcome in these diseases...
January 10, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29323071/scedosporium-apiospermum-an-emerging-pathogen-in-india-case-series-and-review-of-literature
#2
Dabet Rynga, Malini R Capoor, Swati Varshney, Mayuresh Naik, V Gupta
Scedosporium apiospermum is a rare cause of infection but is increasingly being reported among immunocompromised individuals around the world. We report two cases of S. apiospermum, one of keratitis and the other of nasal polyp both from immunocompetent patients. The two cases were successfully treated with voriconazole. It is important to diagnose such infections as their antifungal susceptibility to amphotericin B is variable.
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29283143/ocular-infections-caused-by-scedosporium-apiospermum-a-case-series
#3
Seema Ramakrishnan, Kunal Mandlik, Tejashree Sanket Sathe, Joseph Gubert, Thiruvengada Krishnan, Prabu Baskaran
The aim of our retrospective study is to report a case series of ocular infections caused by a rare fungus, Scedosporium apiospermum, in a South Indian population. Thirteen cases of culture-positive S. apiospermum infections diagnosed between January 2011 and March 2016 were included in this study. The parameters evaluated were predisposing factors, treatment and final clinical outcome. The most common mode of presentation was keratitis (84.6%) followed by sclerokeratitis (15.3%). The predisposing factors involved were unspecified foreign body injury (30...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29274090/case-of-femoral-pseudarthrosis-due-to-scedosporium-apiospermum-in-an-immunocompetent-patient-with-successful-conservative-treatment-and-review-of-literature
#4
Aurélien Dinh, Olivier Demay, Martin Rottman, Fabrice Gaudot, Marie-Elisabeth Bougnoux, Frédérique Bouchand, Hélène Coignard, Claire Rouzaud, Benjamin Davido, Clara Duran, Christophe Nich
Scedosporium apiospermum is a ubiquitous filamentous fungus, commonly found in soil, sewage, and polluted waters. It is rarely pathogenic but can cause a broad spectrum of clinical diseases, which can be localized or disseminate to distant organs. The disseminated form of the disease is mostly seen among immunocompromised patients. However, some rare cases of disseminated disease have been reported in immunocompetent individuals. Treatment of these infections is challenging because of their natural resistance to many antifungal agents...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29228273/direct-detection-of-exophiala-and-scedosporium-species-in-sputa-of-patients-with-cystic-fibrosis
#5
Min Chen, Nahid Kondori, Shuwen Deng, A H G Gerrits van den Ende, M Lackner, Wanqing Liao, G S de Hoog
Detection of species of Exophiala and Scedosporium in the respiratory tracts of cystic fibrosis (CF) patients remains controversial because of highly variable results. The results of our study suggested a significantly higher prevalence and more complex colonization than previously estimated. Approximately 17% (27/162) of clinical sputum samples were found to be positive for Exophiala dermatitidis and 30% (49/162) were positive for Scedosporium apiospermum / S. boydii species complex determined by reverse line blot (RLB) hybridization...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29225727/the-genomic-study-of-an-environmental-isolate-of-scedosporium-apiospermum-shows-its-metabolic-potential-to-degrade-hydrocarbons
#6
Laura T Morales, Laura N González-García, María C Orozco, Silvia Restrepo, Martha J Vives
Crude oil contamination of soils and waters is a worldwide problem, which has been actively addressed in recent years. Sequencing genomes of microorganisms involved in the degradation of hydrocarbons have allowed the identification of several promoters, genes, and degradation pathways of these contaminants. This knowledge allows a better understanding of the functional dynamics of microbial degradation. Here, we report a first draft of the 44.2 Mbp genome assembly of an environmental strain of the fungus Scedosporium apiospermum...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29174563/invasive-fungi-derived-defensins-kill-drug-resistant-bacterial-pathogens
#7
Jiajia Wu, Shijie Liu, Hao Wang
Fungi-derived defensins are a class of antimicrobial peptides with therapeutic potential due to their high antibacterial efficacy and low toxicity. Based on the genomic strategy, we have identified 68 fungal defensin-like peptides (fDLPs) in five new genera, including Trichosporon, Apophysomyces, Lichtheimia, Beauveria and Scedosporium and characterized a new synthetic defensin (scedosporisin) from an invasive fungus. It was active against Gram-positive bacteria but not active against negative bacteria. Importantly, it killed several clinical resistant isolates such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci at low molecular concentrations...
November 21, 2017: Peptides
https://www.readbyqxmd.com/read/29168657/the-hidden-pathogenic-potential-of-environmental-fungi
#8
Glauber R de S Araújo, Wanderley de Souza, Susana Frases
Invasive fungal infections are a growing threat to immunocompromised patients, highlighting the importance of monitoring fungal pathogens. Global warming (including climatic oscillations) may select for environmental species that have acquired thermotolerance, a key step toward pathogenesis to humans. Also, important virulence factors have developed in environmental fungi, because they are essential for yeast survival in the environment. Thus, fungi traditionally regarded as nonpathogenic to humans have virulence factors similar to those of their pathogenic relatives...
November 23, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29116676/salvage-therapy-with-topical-posaconazole-in-lung-transplant-recipients-with-invasive-scedosporium-infection
#9
Amparo Solé, Ana A García-Robles, Carlos Jordá, Enrique Cases Viedma, Nuria Mancheño, José Luis Poveda-Andrés, Juan Pablo Reig Mezquida, Javier Pemán
Scedosporium is an important pathogen in cystic fibrosis (CF) and post-transplant, but it rarely causes invasive infection. Treatment remains challenging, particularly due to the inherent resistance to multiple antifungal agents. We present three complicated invasive tracheobronchial and lung Scedosporium apiospermum infections following lung transplant. In two of three cases, the infection was clinically and radiologically cured with frequent cleansing bronchoscopies, combining triazole with terbinafine therapy and nebulized posaconazole...
November 8, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29111602/scedosporium-apiospermum-infection-of-the-urinary-system-with-a-review-of-treatment-options-and-cases-in-the-literature
#10
Esther Benamu, Alexander Tin-Han Yu, Lijia Xie, Sebastian Fernandez-Pol, Anna Y Liu, Dora Y Ho
Infection with Scedosporium species is associated with significant morbidity and mortality and is becoming increasingly common, especially in immunocompromised patients. We describe the presentation and successful management of an immunocompromised patient with Scedosporium apiospermum infection of the upper urinary tract system, a rare disease manifestation. The current literature on urinary tract scedosporiosis is further reviewed with emphasis on treatment options and limitations of current antifungal therapy...
November 7, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29094263/exophiala-dermatitidis-revealing-cystic-fibrosis-in-adult-patients-with-chronic-pulmonary-disease
#11
Frédéric Grenouillet, Bernard Cimon, Heloise Pana-Katatali, Christine Person, Marie Gainet-Brun, Marie-Claire Malinge, Yohann Le Govic, Bénédicte Richaud-Thiriez, Jean-Philippe Bouchara
Cystic fibrosis (CF) is a genetic inherited disease due to mutations in the gene cystic fibrosis transmembrane conductance regulator (CFTR). Because of the huge diversity of CFTR mutations, the CF phenotypes are highly heterogeneous, varying from typical to mild form of CF, also called atypical CF. These atypical features are more frequently diagnosed at adolescence or adulthood, and among clinical signs and symptoms leading to suspect a mild form of CF, colonization or infection of the respiratory tract due to well-known CF pathogens should be a warning signal...
November 1, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29074141/bullous-necrotic-purpura-caused-by-scedosporium-apiospermum-presenting-with-a-sporotrichoid-pattern
#12
J Company-Quiroga, C Martínez-Morán, A Moreno, J Borbujo
No abstract text is available yet for this article.
October 23, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29069388/the-secreted-polyketide-boydone-a-is-responsible-for-the-anti-staphylococcus-aureus-activity-of-scedosporium-boydii
#13
Cindy Staerck, Anne Landreau, Gaëtan Herbette, Catherine Roullier, Samuel Bertrand, Benjamin Siegler, Gérald Larcher, Jean-Philippe Bouchara, Maxime J J Fleury
Usually living as a soil saprophyte, the filamentous fungus Scedosporium boydii may also cause various infections in human. Particularly, it is one of the major causative agents of fungal colonization of the airways in patients with cystic fibrosis (CF). To compete with other microorganisms in the environment, fungi have evolved sophisticated strategies, including the production of secondary metabolites with antimicrobial activity which may also help them to establish successfully within the respiratory tract of receptive hosts...
October 24, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29044831/a-cluster-of-scedosporiosis-in-lung-transplant-candidates-and-recipients-the-zurich-experience-and-review-of-the-literature
#14
Irene A Abela, Christian Murer, Macé M Schuurmans, Juergen W Schmitt, Frabci Muller, Frank Imkamp, Nicolas J Mueller, Christian Benden
Scedosporium species are fungal pathogens increasingly recognized in cystic fibrosis (CF). They can cause multiresistant, life-threatening infections that are of particular concern in CF patients undergoing lung transplantation, as optimal treatment remains unclear. Here, we describe our Zurich experience of CF patients with Scedosporium infection. Disseminated infection occurred in one patient after transplantation and was successfully treated. We propose a step-by-step approach to treat candidates with colonization, and discuss our cases in the context of the current literature...
October 17, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29031652/-scedosporium-apiospermum-skin-infection-mimicking-a-pyoderma-gangrenosum
#15
C Duretz, P Buchlin, A Huguenin, A Durlach, M Hentzien, S Mestrallet, D Lebrun
No abstract text is available yet for this article.
October 11, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29022198/gene-disruption-in-scedosporium-aurantiacum-proof-of-concept-with-the-disruption-of-sodc-gene-encoding-a-cytosolic-cu-zn-superoxide-dismutase
#16
Victoire Pateau, Bienvenue Razafimandimby, Patrick Vandeputte, Christopher R Thornton, Thomas Guillemette, Jean-Philippe Bouchara, Sandrine Giraud
Scedosporium species are opportunistic pathogens responsible for a large variety of infections in humans. An increasing occurrence was observed in patients with underlying conditions such as immunosuppression or cystic fibrosis. Indeed, the genus Scedosporium ranks the second among the filamentous fungi colonizing the respiratory tracts of the CF patients. To date, there is very scarce information on the pathogenic mechanisms, at least in part because of the limited genetic tools available. In the present study, we successfully developed an efficient transformation and targeted gene disruption approach on the species Scedosporium aurantiacum...
October 11, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28974395/scedosporium-boydii-cata1-and-sodc-recombinant-proteins-new-tools-for-serodiagnosis-of-scedosporium-infection-of-patients-with-cystic-fibrosis
#17
Sara Mina, Cindy Staerck, Agnès Marot, Charlotte Godon, Alphonse Calenda, Jean-Philippe Bouchara, Maxime J J Fleury
Scedosporium species rank the second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (CF), after Aspergillus fumigatus. In CF, these fungi may cause various respiratory infections similar to those caused by A. fumigatus, including bronchitis and allergic broncho-pulmonary mycoses. Diagnosis of these infections relies on the detection of serum antibodies using crude antigenic extracts. However, many components of these extracts are common to Scedosporium and Aspergillus species, leading to cross-reactions...
August 26, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28966527/a-case-of-localized-cutaneous-infection-caused-by-scedosporium-apiospermum-presenting-as-cellulitis
#18
Soo Hyeon Noh, Ga Hye Na, Kun Park, Eun Jung Kim
No abstract text is available yet for this article.
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28963165/first-draft-genome-sequence-of-the-pathogenic-fungus-lomentospora-prolificans-formerly-scedosporium-prolificans
#19
Ruibang Luo, Aleksey Zimin, Rachael Workman, Yunfan Fan, Geo Pertea, Nina Grossman, Maggie P Wear, Bei Jia, Heather Miller, Arturo Casadevall, Winston Timp, Sean X Zhang, Steven L Salzberg
Here we describe the sequencing and assembly of the pathogenic fungus Lomentospora prolificans using a combination of short, highly accurate Illumina reads and additional coverage in very long Oxford Nanopore reads. The resulting assembly is highly contiguous, containing a total of 37,627,092 bp with over 98% of the sequence in just 26 scaffolds. Annotation identified 8896 protein-coding genes. Pulsed-field gel analysis suggests that this organism contains at least 7 and possibly 11 chromosomes, the two longest of which have sizes corresponding closely to the sizes of the longest scaffolds, at 6...
November 6, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28950832/orbital-apex-syndrome-secondary-to-a-fungal-nasal-septal-abscess-caused-by-scedosporium-apiospermum-in-a-patient-with-uncontrolled-diabetes-a-case-report
#20
Ippei Kishimoto, Shogo Shinohara, Tetsuhiro Ueda, Shoichi Tani, Hajime Yoshimura, Yukihiro Imai
BACKGROUND: Orbital apex syndrome is a localized type of orbital cellulitis, where mass lesions occur at the apex of the cranial nerves. Although nasal septal abscess is uncommon, the organism most likely to cause nasal septal abscess is Staphylococcus aureus, and fungal septal abscesses are rare. Here we present an extremely rare and serious case of orbital apex syndrome secondary to fungal nasal septal abscess caused by Scedosporium apiospermum in a patient with uncontrolled diabetes...
September 26, 2017: BMC Infectious Diseases
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