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staphylococcus bacteremia

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https://www.readbyqxmd.com/read/28431847/guideline-compliance-and-clinical-outcomes-among-patients-with-staphylococcus-aureus-bacteremia-with-infectious-diseases-consultation-in-addition-to-antimicrobial-stewardship-directed-review
#1
Kevin Buehrle, Jennifer Pisano, Zhe Han, Natasha N Pettit
OBJECTIVE: Previous studies have shown infectious diseases consultation (IDC) for Staphylococcus aureus bacteremia (SAB) improves management and outcomes. The influence of IDC on outcomes for SAB in addition to an antimicrobial stewardship program (ASP) review for adult inpatients with SAB has not been evaluated. The purpose of this study was to investigate the effect of IDC on SAB management with concomitant ASP review and resulting outcomes. METHODS: Adult inpatients with SAB admitted December 2012-October 2014 were included...
April 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28422567/evaluation-of-serotypes-5-and-8-capsular-polysaccharides-in-protection-against-staphylococcus-aureus-in-murine-models-of-infection
#2
Brian L Cheng, Travis B Nielsen, Paul Pantapalangkoor, Fan Zhao, Jean C Lee, Christopher P Montgomery, Brian Luna, Brad Spellberg, Robert S Daum
Staphylococcus aureus is the leading cause of nosocomial and community-acquired infections, including soft tissue and skin infections and bacteremia. However, efforts to develop an effective vaccine against S. aureus infections have not been successful. We evaluated serotypes 5 and 8 capsule polysaccharides (CP) CRM197 conjugates as vaccine candidates in murine models of bacteremia, lethal sepsis, and skin infection. The conjugate vaccines elicited a good antibody response, and active immunization of CP5-CRM or CP8-CRM conjugates protected against staphylococcal bacteremia...
April 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28421046/horses-in-denmark-are-a-reservoir-of-diverse-clones-of-methicillin-resistant-and-susceptible-staphylococcus-aureus
#3
Md Zohorul Islam, Carmen Espinosa-Gongora, Peter Damborg, Raphael N Sieber, Rikke Munk, Louise Husted, Arshnee Moodley, Robert Skov, Jesper Larsen, Luca Guardabassi
Denmark is a country with high prevalence of livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC) 398 in pigs. Even though pig farming is regarded as the main source of human infection or colonization with MRSA CC398, 10-15% of the human cases appear not to be linked to pigs. Following the recent reports of MRSA CC398 in horses in other European countries and the lack of knowledge on S. aureus carriage in this animal species, we carried out a study to investigate whether horses constitute a reservoir of MRSA CC398 in Denmark, and to gain knowledge on the frequency and genetic diversity of S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28414677/a-rare-case-of-tropical-pyomysitis-acquired-on-vacation-in-a-healthy-male
#4
K Poole, T Tran
INTRODUCTION: Pyomyositis has traditionally been considered a tropical disease. Increasing prevalence has been observed in more northern climates, especially with HIV, immunosuppression, and IV drug abuse as predisposing factors. Pyomyositis has the tendency to mimic other conditions, such as muscle contusion, necrotizing fasciitis, or septic arthritis. The rarity of this disease and non-specificity of its symptoms often lead to delay in appropriate diagnosis and treatment. CASE: 24-year-old man, seen 2 days prior in orthopedics clinic and the Emergency Department for persistent gluteal pain thought to be due to right-sided sciatica, was admitted following worsening pain, diffuse generalized weakness with polyarthralgias and myalgias These symptoms were associated with night sweats, shaking chills, and difficulty walking...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28405808/staphylococcus-lugdunensis-a-neglected-pathogen-of-infections-involving-fracture-fixation-devices
#5
Piseth Seng, Madou Traore, Jean-Philippe Lavigne, Laurence Maulin, Jean-Christophe Lagier, Jean-François Thiery, Pierre-Yves Levy, Pierre-Marie Roger, Eric Bonnet, Albert Sotto, Andreas Stein
PURPOSE: Cases of fracture-fixation device infection involving Staphylococcus lugdunensis are not frequent. The clinical characteristics and the choice of treatment strategies of these infections are not obviously known to date. METHODS: We performed a review of fracture-fixation device infection involving S. lugdunensis managed by our centres. RESULTS: Among the 38 cases of fracture-fixation device infection involving S. lugdunensis, 53% were located in the tibia...
April 12, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28396035/vancomycin-intermediate-staphylococcus-aureus-isolates-are-attenuated-for-virulence-when-compared-to-susceptible-progenitors
#6
David R Cameron, Ya-Hsun Lin, Sophie Trouillet-Assant, Virginie Tafani, Xenia Kostoulias, Effie Mouhtouris, Narelle Skinner, Kumar Visvanathan, Sarah L Baines, Brian Howden, Ian R Monk, Frederic Laurent, Timothy P Stinear, Benjamin P Howden, Anton Y Peleg
OBJECTIVES: Vancomycin-intermediate Staphylococcus aureus (VISA) is associated with genetic changes that may also impact upon pathogenicity. In the current study, we compared the virulence of clinical VISA strains with their isogenic vancomycin-susceptible progenitors (VSSA). METHODS: Production of the critical virulence protein, alpha toxin, was assessed using western blot analysis and was correlated to agr activity using a bioluminescent agr-reporter. Cytotoxicity and intracellular persistence was compared ex vivo for VSSA and VISA within non-professional phagocytes (NPP)...
April 7, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28395434/-efficacy-and-safety-of-linezolid-among-patients-with-methicillin-resistant-staphylococcus-aureus-bacteremia
#7
S L Chen, C Y Zhu, H Zhou, Q Yang, Y H Shen, J Y Zhou
Objective: To study the efficacy and safety of linezolid for the treatment of patients with bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA). Methods: Totally 52 cases of MRSA bacteremia patients, from January 2010 to April 2014 in the First Affiliated Hospital, School of Medicine, Zhejiang University, were retrospectively analyzed. They were classified into two groups based on linezolid therapeutic regimen: primary treatment with linezolid (19 cases) and alternated to linezolid (33 cases)...
April 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28386776/real-world-experience-with-oritavancin-therapy-in-invasive-gram-positive-infections
#8
Cassie L Stewart, Michelle S Turner, Jeremy J Frens, Cynthia B Snider, Jordan R Smith
INTRODUCTION: Oritavancin is a novel lipoglycopeptide approved for acute bacterial skin and skin structure infections. The pharmacokinetic profile and convenient one-time dosing make oritavancin an enticing option for other serious Gram-positive infections requiring prolonged treatment courses. Unfortunately, data for using oritavancin in these populations are limited. METHODS: We report ten cases of oritavancin use for invasive Gram-positive infections in our health system, and provide a review of the currently available literature regarding oritavancin therapy for invasive infections...
April 6, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28381743/clinical-characteristics-of-methicillin-resistant-coagulase-negative-staphylococcal-bacteremia-in-a-tertiary-hospital
#9
Koichi Yamada, Hiroki Namikawa, Hiroki Fujimoto, Kiyotaka Nakaie, Etsuko Takizawa, Yasuyo Okada, Akiko Fujita, Hiroyoshi Kawaguchi, Yasutaka Nakamura, Junko Abe, Yukihiro Kaneko, Hiroshi Kakeya
Objective Coagulase-negative staphylococci are among the most frequently isolated microorganisms in blood cultures. The aim of this study was to assess [1] the clinical characteristics of methicillin-resistant, coagulase-negative staphylococci bacteremia and [2] the susceptibility of the isolated bacteria to glycopeptides. Methods We retrospectively reviewed the medical records of 70 patients from whom methicillin-resistant coagulase-negative staphylococci had been isolated at Osaka City University Hospital between January 2010 and December 2013...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28379366/definitive-treatment-for-methicillin-sensitive-staphylococcus-aureus-bacteremia-data-versus-a-definitive-answer
#10
Adolf W Karchmer
No abstract text is available yet for this article.
March 31, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28379326/an-automated-pharmacist-driven-initiative-improves-quality-of-care-for-staphylococcus-aureus-bacteremia
#11
Eric Wenzler, Fei Wang, Debra A Goff, Beth Prier, John Mellett, Julie E Mangino, Karri A Bauer
Background: Infectious diseases (ID) consultation and antimicrobial stewardship intervention have been shown to improve the management of Staphylococcus aureus bacteremia (SAB). As the workload of antimicrobial stewardship programs (ASPs) continues to increase, ASPs must find a way to maximize the efficiency of the program while optimizing patient outcomes. The objective of this study was to evaluate the impact of incorporating health informatics into the management of SAB via a pharmacist-driven initiative...
April 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28379314/comparative-effectiveness-of-cefazolin-versus-nafcillin-or-oxacillin-for-treatment-of-methicillin-susceptible-staphylococcus-aureus-infections-complicated-by-bacteremia-a-nationwide-cohort-study
#12
Jennifer S McDanel, Mary-Claire Roghmann, Eli N Perencevich, Michael E Ohl, Michihiko Goto, Daniel J Livorsi, Makoto Jones, Justin P Albertson, Rajeshwari Nair, Amy M J O'Shea, Marin L Schweizer
Background: To treat patients with methicillin-susceptible S. aureus (MSSA) infections, beta-lactams are recommended for definitive therapy; however the comparative effectiveness of individual beta-lactams is unknown. This study compared definitive therapy with cefazolin versus nafcillin or oxacillin among patients with MSSA infections complicated by bacteremia. Methods: This retrospective study included patients admitted to 119 Veterans Administration hospitals from 2003 to 2010...
March 31, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28378244/ventilator-associated-pneumonia-by-methicillin-susceptible-staphylococcus-aureus-do-minimum-inhibitory-concentrations-to-vancomycin-and-daptomycin-matter
#13
J Ruiz-Ramos, P Vidal-Cortés, A Díaz-Lamas, R Reig-Valero, F Roche-Campo, M Del Valle-Ortiz, X Nuvials-Casals, M Ortiz-Piquer, D Andaluz-Ojeda, L Tamayo-Lomas, M A Blasco-Navalpotro, M Rodriguez-Aguirregabiria, J Aguado, P Ramirez
The use of vancomycin minimum inhibitory concentration (MIC) as an outcome predictor in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia has become an important topic for debate in the last few years. Given these previous results, we decided to investigate whether MICs to vancomycin or daptomycin had any effect on the evolution of patients with ventilator-associated pneumonia (VAP) due to MSSA. An observational, retrospective, multicenter study was conducted among patients with MSSA VAP...
April 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28378151/-antibiotic-stewardship-and-staphylococcus-aureus-bacteremia
#14
S Weis, A Kimmig, S Hagel, M W Pletz
Rates of antibiotic resistance are increasing worldwide and impact on the treatment of patients with bacterial infections. A broad and uncritical application in inpatient and outpatient settings as well as in agriculture has been recognized as the main driving force. Antibiotic stewardship (ABS) programs aim at countering this worrisome development using various direct interventions such as infectious disease counseling. Blood stream infections caused by Staphylococcus (S.) aureus are severe infections associated with high mortality rates...
April 4, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28365311/clinical-impact-and-prevalence-of-mrsa-cc398-and-differences-between-mrsa-tet-r-and-mrsa-tet-s-in-an-area-of-spain-with-a-high-density-of-pig-farming-a-prospective-cohort-study
#15
E Reynaga, C Torres, M Garcia-Nuñez, M Navarro, A Vilamala, E Puigoriol, G E Lucchetti, M Sabrià
OBJETIVES: Tetracycline-resistance (Tet(R)) is a phenotypic marker of the livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) CC398 clone. The aim of this study was to analyze the prevalence of MRSA CC398 in patients in contact with healthcare facilities and differences between patients with MRSA-Tet(R) and MRSA tetracycline-susceptible (Tet(S)) strains. METHODS: Patients diagnosed with MRSA from January-2012 until December-2015 were divided into two groups, MRSA-Tet(R) and MRSA-Tet(S)...
March 29, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28350900/gram-positive-bacterial-infections-research-priorities-accomplishments-and-future-directions-of-the-antibacterial-resistance-leadership-group
#16
Sarah B Doernberg, Thomas P Lodise, Joshua T Thaden, Jose M Munita, Sara E Cosgrove, Cesar A Arias, Helen W Boucher, G Ralph Corey, Franklin D Lowy, Barbara Murray, Loren G Miller, Thomas L Holland
Antimicrobial resistance in gram-positive bacteria remains a challenge in infectious diseases. The mission of the Gram-Positive Committee of the Antibacterial Resistance Leadership Group (ARLG) is to advance knowledge in the prevention, management, and treatment of these challenging infections to improve patient outcomes. Our committee has prioritized projects involving methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) due to the scope of the medical threat posed by these pathogens...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28336786/-18-f-fdg-pet-ct-optimizes-treatment-in-staphylococcus-aureus-bacteremia-and-is-associated-with-reduced-mortality
#17
Marvin A H Berrevoets, Ilse J E Kouijzer, Erik H J G Aarntzen, Marcel J R Janssen, Lioe-Fee De Geus-Oei, Heiman F L Wertheim, Bart-Jan Kullberg, Jaap Ten Oever, Wim J G Oyen, Chantal P Bleeker-Rovers
Metastatic infection is an important complication of Staphylococcus aureus bacteremia (SAB). Early diagnosis of metastatic infection is crucial, as specific treatment is required. However, metastatic infection can be asymptomatic and difficult to detect. In this study, we investigated the role of (18)F-FDG-PET/CT in patients with SAB for detection of metastatic infection and its consequences for treatment and outcome. Methods: All patients with SAB at Radboud university medical center were included between January 2013 and April 2016...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28332560/evaluating-genetic-susceptibility-to-staphylococcus-aureus-bacteremia-in-african-americans-using-admixture-mapping
#18
D D Cyr, A S Allen, G-J Du, F Ruffin, C Adams, J T Thaden, S A Maskarinec, M Souli, S Guo, D M Dykxhoorn, W K Scott, V G Fowler
The incidence of Staphylococcus aureus bacteremia (SAB) is significantly higher in African American (AA) than in European-descended populations. We used admixture mapping (AM) to test the hypothesis that genomic variations with different frequencies in European and African ancestral genomes influence susceptibility to SAB in AAs. A total of 565 adult AAs (390 cases with SAB; 175 age-matched controls) were genotyped for AM analysis. A case-only admixture score and a mixed χ(2)(1df) score (MIX) to jointly evaluate both single-nucleotide polymorphism (SNP) and admixture association (P<5...
March 23, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28329242/vaccination-induces-cd4-t-cell-mediated-mortality-during-staphylococcus-aureus-bacteremia
#19
Hatice Karauzum, Christian C Haudenschild, Ian N Moore, Mahta Mahmoudieh, Daniel L Barber, Sandip K Datta
Multiple candidate vaccines against Staphylococcus aureus infections have failed in clinical trials. Analysis of a recent prematurely halted vaccine trial revealed increased mortality among vaccine recipients who developed post-surgical S. aureus infection, emphasizing the potential for induction of detrimental immune responses and the need to better understand the requirements for protective immunity against S. aureus. These failures of single antigen vaccines have prompted ongoing development of multi-component vaccines to target the multitude of S...
February 21, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28323886/contribution-of-urinary-tract-infection-to-the-burden-of-febrile-illnesses-in-young-children-in-rural-kenya
#20
Wechuli Geoffrey Masika, Wendy Prudhomme O'Meara, Thomas L Holland, Janice Armstrong
INTRODUCTION: The clinical features of UTI in young children may not localize to the urinary tract and closely resemble other febrile illnesses. In malaria endemic areas, a child presenting with fever is often treated presumptively for malaria without investigation for UTI. Delayed or inadequate treatment of UTI increases the risk of bacteremia and renal scarring in young children and subsequently complications as hypertension and end stage renal disease in adulthood. METHODS: A cross-sectional study was carried out in a hospital in western Kenya...
2017: PloS One
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