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staphylococcus bacteremia

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https://www.readbyqxmd.com/read/29776929/antibacterial-effects-of-phage-lysin-lysgh15-on-planktonic-cells-and-biofilms-of-diverse-staphylococci
#1
Yufeng Zhang, Mengjun Cheng, Hao Zhang, Jiaxin Dai, Zhimin Guo, Xinwei Li, Yalu Ji, Ruopeng Cai, Hengyu Xi, Xinwu Wang, Yibing Xue, Changjiang Sun, Xin Feng, Liancheng Lei, Wenyu Han, Jingmin Gu
Treatment of infections caused by staphylococci has become more difficult because of the emergence of multidrug-resistant strains as well as biofilm formation. In this study, we observed the ability of the phage lysin LysGH15 to eliminate staphylococcal planktonic cells and biofilms formed by Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus hominis All these strains were sensitive to LysGH15, showing reductions in bacterial counts of approximately 4 log units within 30 min after treatment with 20 μg/mL LysGH15, and the minimum inhibitory concentrations (MICs) ranged from 8 μg/mL to 32 μg/mL...
May 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29774878/-etiology-and-risk-factors-for-meningitis-and-or-bacteremia-after-craniotomy-for-patients-with-glioma
#2
Yaning Wang, Yu Wang, Wenbin Ma
To evaluate the incidence and microbiological profile of meningitis and/or bacteremia after craniotomy in patients with glioma and analyze the risk factors relevant to postoperative meningitis.
 Methods: All demographic data, etiological data and clinical data for hospitalized patients who underwent craniotomy in Dept. of Neurosurgery of Peking Union Medical College Hospital between Jan. 2013 to Dec. 2017 were recorded.
 Results: The incidence of post-craniotomy meningitiswas 7.73%, bacteremia was 2.21% and meningitis combined with bacteremia was 1...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29765236/methicillin-resistant-staphylococcus-aureus-bacteremia-among-liver-transplant-recipients-epidemiology-and-associated-risk-factors-for-morbidity-and-mortality
#3
REVIEW
Taohua Liu, Yuezhong Zhang, Qiquan Wan
Bacteremia due to Staphylococcus aureus , especially methicillin-resistant S. aureus (MRSA), complicates the clinical course of liver transplantation and is associated with high morbidity and mortality. Intravascular catheters had been reported to be the most frequent source of MRSA bacteremia. Among bacteremic liver recipients, 26.3%-100% of S. aureus were MRSA. Previous studies identified pre-transplant and post-transplant acquired S. aureus carriage, greater severity of liver disease, hepatocellular carcinoma and infection with immuno-modulatory viruses as predictors of S...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29761760/-staphylococcus-aureus-bacteremia-incidence-and-methicillin-resistance-in-rural-thailand-2006-2014
#4
Devan Jaganath, Possawat Jorakate, Sirirat Makprasert, Ornuma Sangwichian, Thantapat Akarachotpong, Somsak Thamthitiwat, Supphachoke Khemla, Triveni Defries, Henry C Baggett, Toni Whistler, Christopher J Gregory, Julia Rhodes
Staphylococcus aureus is a common cause of bloodstream infection and methicillin-resistant S. aureus (MRSA) is a growing threat worldwide. We evaluated the incidence rate of S. aureus bacteremia (SAB) and MRSA from population-based surveillance in all hospitals from two Thai provinces. Infections were classified as community-onset (CO) when blood cultures were obtained ≤ 2 days after hospital admission and as hospital-onset (HO) thereafter. The incidence rate of HO-SAB could only be calculated for 2009-2014 when hospitalization denominator data were available...
May 14, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29746496/pharyngeal-colonization-and-drug-resistance-profiles-of-morraxella-catarrrhalis-streptococcus-pneumoniae-staphylococcus-aureus-and-haemophilus-influenzae-among-hiv-infected-children-attending-art-clinic-of-felegehiwot-referral-hospital-ethiopia
#5
Wondemagegn Mulu, Endalew Yizengaw, Megbaru Alemu, Daniel Mekonnen, Derese Hailu, Kassaw Ketemaw, Bayeh Abera, Mulugeta Kibret
BACKGROUND: Asymptomatic pharyngeal colonization by potential bacteria is the primary reservoir for bacterial species within a population and is considered a prerequisite for development of major childhood diseases such as sinusitis, otitis media, pneumonia, bacteremia, and meningitis. However, there is dearth of data on the colonization and drug resistance pattern of the main bacterial pathogens in the pharynx of HIV infected children in Ethiopia. Therefore, this study determined the pharyngeal colonization and drug resistance profile of bacterial pathogens in HIV infected children attending ART clinic of Felegehiwot Referral Hospital (FHRH), Amhara Region, Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/29739668/whole-genome-comparison-of-high-and-low-virulent-staphylococcus-aureus-isolates-inducing-implant-associated-bone-infections
#6
Gopala Krishna Mannala, Julian Koettnitz, Walid Mohamed, Ursula Sommer, Katrin Susanne Lips, Cathrin Spröer, Boyke Bunk, Jörg Overmann, Torsten Hain, Christian Heiss, Eugen Domann, Volker Alt
Staphylococcus aureus can cause wide range of infections from simple soft skin infections to severe endocarditis, bacteremia, osteomyelitis and implant associated bone infections (IABI). The focus of the present investigation was to study virulence properties of S. aureus isolates from acute and chronic IABI by means of their in vivo lethality, in vitro osteoblasts invasion, biofilm formation and subsequently whole genome comparison between high and low virulent strains. Application of insect infection model Galleria mellonella revealed high, intermediate and low virulence phenotypes of these clinical isolates, which showed good correlation with osteoblast invasion and biofilm formation assays...
April 25, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29731960/interleukin-26-il-26-is-a-novel-anti-microbial-peptide-produced-by-t-cells-in-response-to-staphylococcal-enterotoxin
#7
Anders Woetmann, Morten Alhede, Sally Dabelsteen, Thomas Bjarnsholt, Morten Rybtke, Claudia Nastasi, Thorbjørn Krejsgaard, Mads Hald Andersen, Charlotte M Bonefeld, Carsten Geisler, Michael Givskov, Niels Odum
Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ , (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29731084/impact-of-pretransplant-infections-on-clinical-course-in-liver-transplant-recipients
#8
Y J Kim, J H Yoon, S I Kim, H J Choi, J Y Choi, S K Yoon, Y-K You, D-G Kim
BACKGROUND: Uncontrolled infections are known to be an absolute contraindication for liver transplantation; however, the posttransplant prognosis of recipients treated for pretransplant infection is unclear. The aim of this study was to analyze pretransplant infections among liver transplant recipients and to determine their impact on posttransplant clinical outcomes. METHODS: This study retrospectively analyzed 357 subjects who had undergone living-donor liver transplantation between January 2008 and May 2014...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29723202/genomic-evolution-of-staphylococcus-aureus-isolates-colonizing-the-nares-and-progressing-to-bacteremia
#9
Jeanne B Benoit, Daniel N Frank, Mary T Bessesen
BACKGROUND: Nasal colonization by Staphylococcus aureus is a key risk factor for bacteremia. The objective of this study is to identify genomic modifications occurring in nasal carriage strains of S. aureus as they progress to bacteremia in a cohort of hospitalized patients. METHODS: Eight patients with S. aureus bacteremia were identified. Genomic sequences of the bloodstream isolates were compared with 57 nasal isolates collected longitudinally prior to the occurrence of bacteremia, which covered a timespan of up to 326 days before bacteremia...
2018: PloS One
https://www.readbyqxmd.com/read/29699836/automatic-notification-and-infectious-diseases-consultation-for-patients-with-staphylococcus-aureus-bacteremia
#10
Lucas Djelic, Nisha Andany, Jeffrey Craig, Nick Daneman, Andrew Simor, Jerome A Leis
Observational studies suggest that Infectious Diseases (ID) consultation is associated with improved outcomes for patients with Staphylococcus aureus bacteremia (SAB), but few studies have sought to standardize timely ID consultation through automatic notification by the Microbiology laboratory. In this 3-year quasi-experimental evaluation, introduction of this change resulted in increased ID consultation for SAB (70% versus 100%, P < 0.001) and decreased time to consultation (14.5 versus 4 h, P < 0...
March 3, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29695270/distinct-t-helper-cell-responses-to-staphylococcus-aureus-bacteremia-reflect-immunologic-comorbidities-and-correlate-with-mortality
#11
Jared A Greenberg, Cara L Hrusch, Mohammad R Jaffery, Michael Z David, Robert S Daum, Jesse B Hall, John P Kress, Anne I Sperling, Philip A Verhoef
BACKGROUND: The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood because these patients are often excluded from studies about septic immunity. The objectives of this study were to determine the immune response to a single pathogen (Staphylococcus aureus) among a diverse case mix of patients and to determine whether comorbidities affect immune and clinical outcomes...
April 25, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29691140/interaction-between-the-staphylococcus-aureus-extracellular-adherence-protein-eap-and-its-subdomains-with-platelets
#12
Raghavendra Palankar, Ulrike Binsker, Bianca Haracska, Jan Wesche, Andreas Greinacher, Sven Hammerschmidt
S. aureus associated bacteremia can lead to severe infections with high risk of mortality (e.g. sepsis, infective endocarditis). Many virulence factors and adhesins of S. aureus are known to directly interact with platelets. Extracellular adherence protein, Eap, one of the most important virulence factors in S. aureus mediated infections is a multi-tandem domain protein and has been shown to interact with almost all cell types in the human circulatory system. By using amine reactive fluorescent N-hydroxysuccinimidyl (NHS)-ester dyes and by direct detection with primary fluorescently conjugated anti-histidine (His-tag) antibodies against detect N-terminal His6, we show Eap subdomain Eap D3 D4 specifically interacts and rapidly activates human platelets...
April 18, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29680695/microbiological-quality-and-antimicrobial-resistance-characterization-of-salmonella-spp-in-fresh-milk-value-chains-in-ghana
#13
Angela Parry-Hanson Kunadu, Mark Holmes, Eric L Miller, Andrew J Grant
Consumer perception of poor hygiene of fresh milk products is a major barrier to promotion of milk consumption as an intervention to alleviate the burden of malnutrition in Ghana. Fresh milk is retailed raw, boiled, or processed into unfermented cheese and spontaneously fermented products in unlicensed outlets. In this study, we have determined microbiological quality of informally retailed fresh milk products and characterized the genomic diversity and antimicrobial resistance (AMR) patterns of non-typhoidal Salmonella (NTS) in implicated products...
April 14, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29675919/therapy-and-outcome-of-staphylococcus-aureus-infections-of-intracorporeal-ventricular-assist-devices
#14
Miquel B Ekkelenkamp, Mats T Vervoorn, Jumamurat R Bayjanov, Ad C Fluit, Barry J Benaissa-Trouw, Faiz Z Ramjankhan
Infection of the driveline or pump pocket is a common complication in patients with ventricular assist devices (VADs) and Staphylococcus aureus is the main pathogen causing such infections. Limited evidence is currently available to guide the choice of antibiotic therapy and the duration of treatment in these patients. Patients at the University Medical Center Utrecht who developed a VAD-related S. aureus infection between 2007 and 2016 were retrospectively assessed. Blood culture isolates were typed by whole genome sequencing to differentiate between relapses and reinfections, and to determine whether antibiotic therapy had led to acquisition of resistance mutations...
April 19, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29671041/oropharyngeal-and-nasopharyngeal-decontamination-with-chlorhexidine-gluconate-in-lung-cancer-surgery-a-randomized-clinical-trial
#15
Xavier Benoit D'Journo, Pierre-Emmanuel Falcoz, Marco Alifano, Jean-Philippe Le Rochais, Thomas D'Annoville, Gilbert Massard, Jean Francois Regnard, Philippe Icard, Charles Marty-Ane, Delphine Trousse, Christophe Doddoli, Bastien Orsini, Sophie Edouard, Matthieu Million, Nathalie Lesavre, Anderson Loundou, Karine Baumstarck, Florence Peyron, Stephane Honoré, Stéphanie Dizier, Aude Charvet, Marc Leone, Didier Raoult, Laurent Papazian, Pascal Alexandre Thomas
PURPOSE: Respiratory complications are the leading causes of morbidity and mortality after lung cancer surgery. We hypothesized that oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate (CHG) would be an effective method to reduce these complications as reported in cardiac surgery. METHODS: In this multicenter parallel-group randomized double-blind placebo-controlled trial, we enrolled consecutive adults scheduled for anatomical pulmonary resection for lung cancer...
April 18, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29670602/human-genetic-susceptibility-to-native-valve-staphylococcus-aureus-endocarditis-in-patients-with-s-aureus-bacteremia-genome-wide-association-study
#16
Karen Moreau, Alisson Clemenceau, Vincent Le Moing, David Messika-Zeitoun, Paal S Andersen, Niels E Bruun, Robert L Skov, Florence Couzon, Coralie Bouchiat, Marie L Erpelding, Alex van Belkum, Yohan Bossé, Xavier Duval, Francois Vandenesch
Staphylococcus aureus infective endocarditis (SaIE) is a severe complication of S. aureus bacteremia (SAB) occurring in up to 22% of patients. Bacterial genetic factors and host conditions for SaIE have been intensely studied before; however, to date no study has focused on predisposing host genetic factors to SaIE. The present study aimed to identify genetic polymorphisms associated with SaIE by a Genome-Wide Association Study (GWAS) of 67 patients with definite native valve SaIE (cases) and 72 matched native valve patients with SAB but without IE (controls)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29667110/gender-affects-prognosis-of-methicillin-resistant-staphylococcus-aureus-bacteremia-differently-depending-on-the-severity-of-underlying-disease
#17
Chang Kyung Kang, Yee Gyung Kwak, Youngmi Park, Kyoung-Ho Song, Eu Suk Kim, Sook-In Jung, Kyung-Hwa Park, Wan Beom Park, Nam Joong Kim, Young Keun Kim, Hee-Chang Jang, Shinwon Lee, Jae Hyun Jeon, Ki Tae Kwon, Chung-Jong Kim, Yeon-Sook Kim, Hong Bin Kim
We aimed to elucidate the potential impact of gender on prognosis of Staphylococcus aureus bacteremia (SAB). We analyzed SAB cases prospectively collected over an 8-year period at 11 hospitals in Korea. SAB-related mortality was pre-defined as a death within 30 days from the onset of SAB without other apparent cause of death. The effect of gender on SAB-related mortality was examined in the entire cohort and in subgroups stratified according to methicillin resistance and Charlson's comorbidity-weighted index (CCWI) score...
April 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29664994/predictors-of-mortality-with-staphylococcus-aureus-bacteremia-in-elderly-adults
#18
Matteo Bassetti, Elda Righi, Paola Del Giacomo, Assunta Sartor, Filippo Ansaldi, Cecilia Trucchi, Cristiano Alicino, Enrico Maria Trecarichi, Teresa Spanu, Chiara Paganino, Mario Tumbarello, Alessia Carnelutti
OBJECTIVES: To analyze risk factors for early and late mortality in individuals aged 75 and older with Staphylococcus aureus bacteremia (SAB) in Italy. DESIGN: Four-year retrospective observational study (January 2011-December 2014). SETTING: Two tertiary care university hospitals in Italy (Santa Maria Misericordia Hospital in Udine, Policlinico Universitario Agostino Gemelli in Rome). PARTICIPANTS: All adults consecutively admitted with SAB...
April 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29657725/adherence-rate-of-quality-of-care-indicators-for-staphylococcus-aureus-bacteremia-is-extremely-low-in-japanese-emergency-and-critical-care-departments-a-multicenter-retrospective-observational-study
#19
Kyohei Miyamoto, Seiya Kato, Junichi Kitayama, Junpei Okawa, Ayana Okamoto, Jun Kamei, Kazuhisa Yoshiya, Hideki Asai, Shingo Adachi, Hidekazu Yukioka, Hiroshi Akimoto, Kazuo Okuchi
Aim: Staphylococcus aureus bacteremia causes significant morbidity and mortality and requires specific management to prevent complications. Most studies evaluating quality of care have been carried out in Europe and North America, and accurate epidemiological data are lacking in Asia. We aimed to describe the epidemiology and evaluate the quality of care for S. aureus bacteremia in Japan. Methods: From February 2011 to January 2014, we undertook a multicenter retrospective observational study in 10 departments of emergency and critical care in Japan...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29651827/influence-of-pharmacokinetic-pharmacodynamic-ratio-on-vancomycin-treatment-response-in-paediatric-patients-with-staphylococcus-aureus-bacteremia
#20
Jesus Ruiz, Ana García-Robles, María R Marqués, Maria J Company, Antonio Solana, Jose L Poveda
BACKGROUND: Staphylococcus aureus is a frequent cause of hospital-acquired bacteremia in paediatrics patients. Vancomycin is the drug of choice for the treatment of methicillin-resistant strains, although treatment failure is frequently observed. Area under the curve (AUC) of plasma concentrations over the minimum inhibitory concentration (MIC) has been proposed as the best index to predict treatment response, although information about its clinical impact on paediatric patients is scarce...
April 12, 2018: Minerva Pediatrica
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