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staphylococcus bacteremia

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https://www.readbyqxmd.com/read/29163457/the-agr-quorum-sensing-system-represses-persister-formation-through-regulation-of-phenol-soluble-modulins-in-staphylococcus-aureus
#1
Tao Xu, Xu-Yang Wang, Peng Cui, Yu-Meng Zhang, Wen-Hong Zhang, Ying Zhang
The opportunistic pathogen Staphylococcus aureus has become an increasing threat to public health. While the Agr quorum sensing (QS) system is a master regulator of S. aureus virulence, its dysfunction has been frequently reported to promote bacteremia and mortality in clinical infections. Here we show that the Agr system is involved in persister formation in S. aureus. Mutation of either agrCA or agrD but not RNAIII resulted in increased persister formation of stationary phase cultures. RNA-seq analysis showed that in stationary phase AgrCA/AgrD and RNAIII mutants showed consistent up-regulation of virulence associated genes (lip and splE, etc...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29161942/trends-in-incidence-and-resistance-patterns-of-staphylococcus-aureus-bacteremia
#2
Elina Jokinen, Janne Laine, Reetta Huttunen, Outi Lyytikäinen, Risto Vuento, Jaana Vuopio, Jaana Syrjänen
BACKGROUND: Staphylococcus aureus bacteremia (SAB) causes a significant burden on the population. Several infection control measures have been implemented in Pirkanmaa county to combat a local epidemic with methicillin-resistant Staphylococcus aureus (MRSA). We aimed to study the epidemiology of SAB and antibiotic resistance of S. aureus and the possible influence of improved infection control. METHODS: Register data from 2005 to 2015 were retrospectively analysed to study the antimicrobial susceptibility, the incidence and mortality in SAB in a population-based setting...
November 21, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29156865/antibacterial-resistance-patterns-and-incidence-of-hospital-acquired-staphylococcus-aureus-bacteremia-in-a-tertiary-care-educational-hospital-in-turkey-a-perspective-from-2001-to-2013
#3
Oğuz Reşat Sipahi, Serhat Uysal, Sabire Şöhret Aydemir, Hüsnü Pullukçu, Meltem Taşbakan, Alper Tünger, Fatma Feriha Çilli, Tansu Yamazhan, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy
Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013. Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29153509/transcatheter-embolization-of-a-giant-coronary-artery-pseudoaneurysm
#4
Pratik Dalal, Divyashree Varma, Ripa Chakravorty, Salil Sethi, Steven Bailey, Anand Prasad
A 53-year-old diabetic male with sternal dehiscence presented with recurrent staphylococcus bacteremia 2years after coronary artery bypass grafting (CABG). He was found to have a giant right coronary artery (RCA) pseudoaneurysm and a coronary cameral fistula on imaging. Due to excessive surgical risk, the patient underwent percutaneous treatment with a 5mm Amplatzer vascular plug 4 (St. Jude Medical, St.Paul, MN). Post-procedure imaging showed successful cessation of flow into the pseudoaneurysm and follow-up CT scan demonstrated significant improvement in the size of the pseudoaneurysm...
November 16, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29153470/impact-of-a-pharmacist-driven-care-package-on-staphylococcus-aureus-bacteremia-management-in-a-large-community-healthcare-network-a-propensity-score-matched-quasi-experimental-study
#5
Jordan R Smith, Jeremy J Frens, Cynthia B Snider, Kimberly C Claeys
OBJECTIVES: Staphylococcus aureus bacteremia (SAB) is an important cause of morbidity and mortality. Suboptimal treatment has been associated with poor patient outcomes. Our antimicrobial stewardship program (ASP) evaluated SAB management based on predefined performance measures both prior to and after instituting a "care package" intervention led by clinical pharmacists and infectious diseases physicians. The primary outcome included a 4-point "optimal care score" (OCS) consisting of targeted antibiotic therapy within 24hours, repeating blood cultures, antibiotic duration assessment, and appropriate duration of therapy...
October 7, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29149185/linezolid-and-atorvastatin-impact-on-pneumonia-caused-by-staphyloccocus-aureus-in-rabbits-with-or-without-mechanical-ventilation
#6
Laure-Anne Pauchard, Mathieu Blot, Rémi Bruyere, Saber-Davide Barbar, Delphine Croisier, Lionel Piroth, Pierre-Emmanuel Charles
Pneumonia may involve methicillin-resistant Staphylococcus aureus (MRSA), with elevated rates of antibiotics failure. The present study aimed to assess the effect of statins given prior to pneumonia development. Spontaneously breathing (SB) or mechanically ventilated (MV) rabbits with pneumonia received atorvastatin alone, linezolid (LNZ) alone, or a combination of both (n = 5 in each group). Spontaneously breathing and MV untreated infected animals (n = 11 in each group), as well as uninfected animals (n = 5 in each group) were used as controls...
2017: PloS One
https://www.readbyqxmd.com/read/29139180/successful-heart-transplantation-in-patients-with-active-staphylococcus-bloodstream-infection-and-suspected-mechanical-circulatory-support-device-infection
#7
Timothy Sullivan, Sarah Taimur, Meenakshi Rana, Gopi Patel, Sean Pinney, Anelechi Anyanwu, Shirish Huprikar
BACKGROUND: An active bloodstream infection (BSI) is typically considered a contraindication to heart transplantation (HT). However, in some patients with Staphylococcus bacteremia and mechanical circulatory support device infection, positive blood cultures may persist until removal of the infected device, and eradicating the infection prior to HT may not be possible. We report the outcomes of six patients with active Staphylococcus BSI at the time of HT. METHODS: All cases of HT performed at The Mount Sinai Hospital from 2009 through 2015 were reviewed...
November 15, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29137718/telavancin-for-the-treatment-of-methicillin-resistant-staphylococcus-aureus-bone-and-joint-infections
#8
Julie Harting, Francisco Fernandez, Rob Kelley, Tim Wiemken, Paula Peyrani, Julio Ramirez
This retrospective, case series describes our experience with the use of telavancin in patients with methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis and prosthetic joint infection. The primary objectives were clinical outcomes and adverse events (AEs), and a secondary outcome described microbiological susceptibility. Fourteen patients were enrolled. Median duration of therapy was 58 days, and four patients had concurrent bacteremia. End-of-treatment outcomes were available in 78% of patients, with a clinical success rate of 91%...
December 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29134582/long-term-efficacy-of-comprehensive-multidisciplinary-antibiotic-stewardship-programs-centered-on-weekly-prospective-audit-and-feedback
#9
Takeshi Kimura, Atsushi Uda, Tomoyuki Sakaue, Kazuhiko Yamashita, Tatsuya Nishioka, Sho Nishimura, Kei Ebisawa, Manabu Nagata, Goh Ohji, Tatsuya Nakamura, Chihiro Koike, Mari Kusuki, Takeshi Ioroi, Akira Mukai, Yasuhisa Abe, Hiroyuki Yoshida, Midori Hirai, Soichi Arakawa, Ikuko Yano, Kentaro Iwata, Issei Tokimatsu
OBJECTIVE: To evaluate the long-term effects of comprehensive antibiotic stewardship programs (ASPs) on antibiotic use, antimicrobial-resistant bacteria, and clinical outcomes. DESIGN: Before-after study. SETTING: National university hospital with 934 beds. INTERVENTION: Implementation in March 2010 of a comprehensive ASPs including, among other strategies, weekly prospective audit and feedback with multidisciplinary collaboration...
November 13, 2017: Infection
https://www.readbyqxmd.com/read/29134234/light-in-the-dark-18-f-fdg-pet-ct-in-staphylococcus-aureus-bacteremia-of-unknown-origin
#10
Jacopo Colombo, Luigia Elzi, Giorgio Treglia, Andreas Perren
No abstract text is available yet for this article.
November 13, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29133561/outcomes-of-vancomycin-plus-a-%C3%AE-lactam-versus-vancomycin-only-for-the-treatment-of-methicillin-resistant-staphylococcus-aureus-bacteremia
#11
James Truong, John J Veillette, Steve C Forland
The objective of this retrospective study was to compare the rates of treatment failure, which was a composite of clinical and microbiologic failure, of patients receiving vancomycin and a β-lactam to those receiving vancomycin only for MRSA bacteremia. Patients 16 to 89 years of age with MRSA bacteremia admitted to a university-affiliated hospital from January 1(st), 2014 to December 31(st), 2016 were screened for study inclusion. Patients were eligible if they received >48 hours of vancomycin and a β-lactam (combination group) or vancomycin only (standard group) within 48 hours following bacteremia onset...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29129031/evaluation-and-management-of-staphylococcus-aureus-bacteriuria-an-updated-review
#12
REVIEW
Stamatis Karakonstantis, Dimitra Kalemaki
BACKGROUND AND AIMS: There is little guidance regarding the evaluation and management of patients with Staphylococcus aureus bacteriuria (SABU). Here, we aimed to provide an up-to-date review of the literature. METHODS: We searched PubMed, Scopus, and clinical trial registries for articles evaluating the epidemiology of SABU, risk factors of SABU, the association of SABU with urinary tract infection, bacteremia and invasive S. aureus infections, and the management of patients with SABU...
November 11, 2017: Infection
https://www.readbyqxmd.com/read/29115883/pharmacotherapeutic-options-for-treating-staphylococcus-aureus-bacteremia
#13
Carlota Gudiol, Guillermo Cuervo, Evelyn Shaw, Miquel Pujol, Jordi Carratalà
Case-fatality rates for Staphylococcus aureus bacteremia (SAB) remain unacceptably high and have improved only modestly in recent decades. Treatment of SAB is still a clinical challenge, especially if methicillin-resistant strains are involved. New drugs with anti-staphylococcal activity are currently available, and their role as alternatives to standard therapies is being investigated. Areas covered: In this review, we give an update of the current available antibiotics for the treatment of SAB. We provide information regarding the pharmacological characteristics, the accepted indications, and the most important adverse events of the old and new anti- staphylococcal agents, as well as the existing evidence on their use for the treatment of SAB...
November 8, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29111401/biofilm-production-is-not-associated-with-poor-clinical-outcome-in-485-patients-with-staphylococcus-aureus-bacteremia
#14
María Guembe, Beatriz Alonso, José Lucio, María Jesús Pérez-Granda, Raquel Cruces, Carlos Sánchez-Carrillo, Ana Fernández-Cruz, Emilio Bouza
OBJECTIVE: Staphylococcus aureus biofilm may constitute a major cause of virulence. Our main objective was to analyze whether there was an association between biofilm production and poor outcome in patients with S. aureus bacteremia. METHODS: We studied 485 S. aureus strains isolated from the blood of patients with bacteremia from 2012 to 2015. We assessed in vitro biomass production using the crystal violet assay (CV) and metabolic activity using the tetrazolium salt assay (XTT)...
October 27, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29103153/humoral-immune-consequences-of-staphylococcus-aureus-st239-associated-bacteremia
#15
H Ghasemzadeh-Moghaddam, Wjb van Wamel, A van Belkum, R A Hamat, M Tavakol, V K Neela
The humoral immune responses against 46 different staphylococcal antigens in 27 bacteremia patients infected by clonally related methicillin-resistant Staphylococcus aureus (MRSA) strains of a single sequence type (ST) 239 were investigated. A group of non-infected patients (n = 31) hospitalized for different reasons served as controls. All strains were confirmed as ST 239 by S. aureus and mecA-specific PCR, spa, and multi-locus sequence typing (MLST). In each bacteremia patient, a unique pattern of S. aureus antigen-specific immune responses after infection was observed...
November 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29081626/ceftriaxone-for-the-treatment-of-methicillin-susceptible-staphylococcus-aureus-bacteremia-a-case-series
#16
Rachel Amanda Lowe, Katie Elizabeth Barber, Jamie Leigh Wagner, Allison Miriam Bell-Harlan, Kayla Renay Stover
Methicillin-susceptible Staphylococcus aureus (MSSA) causes 45% of S. aureus bloodstream infections (BSI) and is the most important cause of BSI-associated death. The standard of care therapy is an anti-staphylococcal penicillin or cefazolin, but dosing frequencies for these agents are often infeasible; multiple daily doses tie up infusion lines and are impractical for outpatient antibiotic infusion. Ceftriaxone represents a promising alternative, with once daily dosing and a short infusion time. Currently, treatment with ceftriaxone for invasive MSSA infections is infrequent, with minimal data supporting the clinical utility of ceftriaxone for MSSA BSI...
July 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/29077854/investigation-of-a-cluster-of-sequence-type-22-methicillin-resistant-staphylococcus-aureus-transmission-in-a-community-setting
#17
Michelle S Toleman, Emmeline R Watkins, Tom Williams, Beth Blane, Belinda Sadler, Ewan M Harrison, Francesc Coll, Julian Parkhill, Bernadette Nazareth, Nicholas M Brown, Sharon J Peacock
Background: Whole-genome sequencing (WGS) has typically been used to confirm or refute hospital/ward outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) identified through routine practice. However, appropriately targeted WGS strategies that identify routinely "undetectable" transmission remain the ultimate aim. Methods: WGS of MRSA isolates sent to a regional microbiological laboratory was performed as part of a 12-month prospective observational study...
October 25, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29072402/outcomes-of-high-risk-patients-with-febrile-neutropenia-at-a-tertiary-care-center
#18
Asif Husain Osmani, Adnan Abdul Jabbar, Manesh Kumar Gangwani, Bilal Hassan
Fever during chemotherapy-induced neutropenia continues to be a major cause of morbidity and mortality in cancer patients. Mortality depends on the duration and degree of neutropenia, bacteremia, sepsis, performance status, comorbidities and other parameters. The highest mortality rates in cancer patients hospitalized with febrile neutropenia (FN) are observed in those with documented infection. The objectives of the study were to present available tools for risk assessment, to review pathogens causing infections in adult FN patients and to assess outcomes...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29068235/comment-rifampin-resistant-staphylococcus-aureus-bacteremia-in-a-patient-on-chronic-rifaximin
#19
Herbert L DuPont, Jasmohan S Bajaj
No abstract text is available yet for this article.
October 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29066569/closing-the-brief-case-bacteremia-and-vertebral-osteomyelitis-due-to-staphylococcus-schleiferi
#20
EDITORIAL
Melanie L Yarbrough, Yasir Hamad, C A Burnham, Ige A George
No abstract text is available yet for this article.
November 2017: Journal of Clinical Microbiology
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