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staphylococcus bacteremia

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https://www.readbyqxmd.com/read/29349940/etiology-of-invasive-bacterial-infections-in-immunocompetent-children-in-korea-2006-2010-a-retrospective-multicenter-study
#1
Kyuyol Rhie, Eun Hwa Choi, Eun Young Cho, Jina Lee, Jin Han Kang, Dong Soo Kim, Yae Jean Kim, Youngmin Ahn, Byung Wook Eun, Sung Hee Oh, Sung Ho Cha, Young Jin Hong, Kwang Nam Kim, Nam Hee Kim, Yun Kyung Kim, Jong Hyun Kim, Taekjin Lee, Hwang Min Kim, Kun Song Lee, Chun Soo Kim, Su Eun Park, Young Mi Kim, Chi Eun Oh, Sang Hyuk Ma, Dae Sun Jo, Young Youn Choi, Hoan Jong Lee
BACKGROUND: Invasive bacterial infections in apparently immunocompetent children were retrospectively analyzed to figure causative bacterial organisms in Korea. METHODS: A total of 947 cases from 25 university hospitals were identified from 2006 to 2010 as a continuance of a previous 10-year period study from 1996 to 2005. RESULTS: Escherichia coli (41.3%), Streptococcus agalactiae (27.7%), and Staphylococcus aureus (27.1%) were the most common pathogens in infants < 3 months of age...
February 5, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29347812/reevaluation-of-the-impact-of-methicillin-resistance-on-outcomes-in-patients-with-staphylococcus-aureus-bacteremia-and-endocarditis
#2
Eun-Jeong Joo, Dong Ah Park, Cheol-In Kang, Doo Ryeon Chung, Jae-Hoon Song, Sang Moo Lee, Kyong Ran Peck
Background/Aims: Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals, and has recently emerged in the community. The impact of methicillin-resistance on mortality and medical costs for patients with S. aureus bacteremia (SAB) requires reevaluation. Methods: We searched studies with SAB or endocarditis using electronic databases including Ovid-Medline, Embase-Medline, and Cochrane Library, as well as five local databases for published studies during the period January 2000 to September 2011...
January 20, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29333818/community-acquired-methicillin-resistant-staphylococcus-aureus-infections-hospitalization-and-case-fatality-risk-in-10-pediatric-facilities-in-argentina
#3
Ángela Gentile, Julia Bakir, Gabriela Ensinck, Aldo Cancellara, Enrique V Casanueva, Verónica Firpo, Martín Caruso, María F Lución, Alejandro Santillán Iturres, Fabiana Molina, Héctor J Abate, Andrea Gajo Gane, Santiago López Papucci
INTRODUCTION: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are prevalent both in Argentina and worldwide, and they may have a severe clinical course. OBJECTIVES: To estimate the hospitalization rate and case fatality risk factors of CA-MRSA infection. METHODS: Cross-sectional, analytical study. All patients < 15 years old with community-acquired Staphylococcus aureus (CA-SA) infections admitted to 10 pediatric facilities between January 2012 and December 2014 were included...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29322242/utility-of-fosfomycin-as-antibacterial-prophylaxis-in-patients-with-hematologic-malignancies
#4
Tanya Zapolskaya, Sarah Perreault, Dayna McManus, Jeffrey E Topal
PURPOSE: Prolonged and profound neutropenia is common among hematology and hematopoietic stem cell transplant (HSCT) patients as a result of chemotherapy. The National Comprehensive Cancer Network (NCCN) and Infectious Diseases Society of America (IDSA) currently recommend antibacterial prophylaxis in patients who are deemed at intermediate or high risk for infection. Specifically, fluoroquinolone prophylaxis should be considered for high-risk neutropenic patients. However, with prolonged and frequent exposure to fluoroquinolones, these high-risk patients may develop resistance to these agents...
January 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29320659/iris-abscess
#5
Xuejing Chen, Caroline R Baumal
A 25-year-old woman presented to the retina clinic with progressive pain and redness in her right eye. She had a history of intravenous drug use, and 1 week before presentation she had received a diagnosis of methicillin-sensitive Staphylococcus aureus bacteremia and endocarditis, for which she was..
January 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29305961/no-effect-of-vancomycin-mic-%C3%A2-1-5-mg-l-on-treatment-outcome-in-methicillin-susceptible-staphylococcus-aureus-bacteremia
#6
Kevin Bouiller, Caroline Laborde, Serge Ludwig Aho, Didier Hocquet, André Pechinot, Vincent Le Moing, Xavier Bertrand, Lionel Piroth, Catherine Chirouze
OBJECTIVES: The vancomycin minimum inhibitory concentration (MIC) has been shown to affect the outcome of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. In this study, the outcomes of patients with MSSA bacteremia, with a vancomycin MIC≥ 1.5 mg/L were assessed. METHODS: A prospective cohort of patients with MSSA bacteremia in two tertiary-care hospitals was collected. Vancomycin MIC was determined by Etest. SA strains were categorized as low (<1...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29300363/unusually-high-incidences-of-staphylococcus-aureus-infection-within-studies-of-ventilator-associated-pneumonia-prevention-using-topical-antibiotics-benchmarking-the-evidence-base
#7
James C Hurley
Selective digestive decontamination (SDD, topical antibiotic regimens applied to the respiratory tract) appears effective for preventing ventilator associated pneumonia (VAP) in intensive care unit (ICU) patients. However, potential contextual effects of SDD on Staphylococcus aureus infections in the ICU remain unclear. The S. aureus ventilator associated pneumonia (S. aureus VAP), VAP overall and S. aureus bacteremia incidences within component (control and intervention) groups within 27 SDD studies were benchmarked against 115 observational groups...
January 4, 2018: Microorganisms
https://www.readbyqxmd.com/read/29298323/implementation-of-global-antimicrobial-resistance-surveillance-system-glass-in-patients-with-bacteremia
#8
Rujipas Sirijatuphat, Kantarida Sripanidkulchai, Adhiratha Boonyasiri, Pinyo Rattanaumpawan, Orawan Supapueng, Pattarachai Kiratisin, Visanu Thamlikitkul
The global antimicrobial resistance surveillance system (GLASS) was launched by the World Health Organization (WHO) in 2015. GLASS is a surveillance system for clinical specimens that are sent to microbiology laboratory for clinical purposes. The unique feature of GLASS is that clinical data is combined with microbiological data, and deduplication of the microbiological results is performed. The objective of the study was to determine feasibility and benefit of GLASS for surveillance of blood culture specimens...
2018: PloS One
https://www.readbyqxmd.com/read/29297750/a-d-alanine-auxotrophic-live-vaccine-is-effective-against-lethal-infection-caused-by-staphylococcus-aureus
#9
Miriam Moscoso, Patricia García, Maria P Cabral, Carlos Rumbo, Germán Bou
Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant derivative of S. aureus 132 which lacks the genes involved in D-alanine biosynthesis, a structural component of cell wall peptidoglycan. This unmarked deletion mutant requires the exogenous addition of D-alanine for in vitro growth...
January 3, 2018: Virulence
https://www.readbyqxmd.com/read/29235661/association-of-higher-daptomycin-dose-%C3%A2-7-mg-kg-with-improved-survival-in-patients-with-methicillin-resistant-staphylococcus-aureus-bacteremia
#10
Tristan T Timbrook, Aisling R Caffrey, Megan K Luther, Vrishali Lopes, Kerry L LaPlante
STUDY OBJECTIVE: Current guidelines recommend higher daptomycin doses than the daptomycin label dose of 6 mg/kg for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, the evidence supporting this recommendation is from in vitro and cases series studies. The objective of this study was to evaluate the comparative effectiveness of the daptomycin label dose versus higher daptomycin doses in patients with MRSA bacteremia. DESIGN: Retrospective national cohort study...
December 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29228127/antibiotic-resistance-and-the-risk-of-recurrent-bacteremia
#11
Sjoukje H S Woudt, Sabine C de Greeff, Annelot F Schoffelen, Anne L M Vlek, Marc J M Bonten
Background: Direct health effects of antibiotic resistance are difficult to assess. We quantified the risk of recurrent bacteremia associated with antibiotic resistance. Methods: We extracted antimicrobial susceptibility testing data on blood isolates of Enterobacteriaceae, Pseudomonas spp., Enterococcus spp. and Staphylococcus aureus from the Dutch surveillance system for antimicrobial resistance between 2008 and 2017. First and first recurrent (4-30days) bacteremia episodes were categorized as susceptible, single non-susceptible or co-non-susceptible (I/R), to 3rd generation cephalosporins -/+ carbapenems (Enterobacteriaceae), ceftazidime -/+ carbapenems (Pseudomonas spp...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29222405/multiple-weekly-dalbavancin-dosing-for-the-treatment-of-native-vertebral-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-report
#12
Thamer A Almangour, Valerie Fletcher, Mohammed Alessa, Abdullah A Alhifany, Deanne Tabb
BACKGROUND Native vertebral osteomyelitis (NVO) is a common form of hematogenous osteomyelitis, with Staphylococcus aureus (S. aureus) being the most commonly isolated organism. Dalbavancin is approved by the US Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and has a sufficiently promising pharmacokinetic and pharmacodynamic profile to be considered for the treatment of vertebral osteomyelitis. We describe here what is probably the first reported case of using multiple weekly dalbavancin to treat a complicated methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and vertebral osteomyelitis...
December 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29203479/host-pathogen-treatment-triad-host-factors-matter-most-in-mrsa-bacteremia-outcomes
#13
M Cristina Vazquez Guillamet, Rodrigo Vazquez, Benjamin Deaton, Jenny Shroba, Laia Vazquez, Renee-Claude Mercier
Background: Previous studies have separately emphasized the importance of host, pathogen and treatment characteristics in determining short term or in-hospital mortality for patients with methicillin resistant Staphylococcus aureus (MRSA) bloodstream infections. Less is known about the relative importance of these factors and their interaction in determining short, medium and long-term mortality.Methods: This is an observational cohort study where all patients admitted to University of New Mexico Health Sciences Center (UNM HSC) between July 2002 and August 2013 with MRSA positive blood cultures were recorded...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29189727/staphylococcus-aureus-bacteremia-from-diffuse-muscular-infection-following-acupuncture-visualized-by-18f-fdg-pet-ct-and-mri
#14
Andreas Knudsen, Carsten Thomsen, Lothar Wiese
We describe the clinical course of a 60-year old male admitted with Staphylococcus aureus bacteremia and back-pain. The patient was suspected of having spondylitis and treated as such with antibiotics; however, both fluorine-18 fluoro-2-deoxy-d-glucose (18F-FDG) positron-emission tomography and magnetic resonance imaging (MRI) with iv contrast showed significant inflammation of muscles and subcutaneous soft tissue in relation to the patients back and left shoulder, but no signs of the working diagnosis of spondylitis...
November 30, 2017: Diagnostics
https://www.readbyqxmd.com/read/29180523/efficacy-of-novel-anti-staphylococcal-ectolysin-p128-in-a-rat-model-of-methicillin-resistant-staphylococcus-aureus-mrsa-bacteremia
#15
Shankaramurthy Channabasappa, Murali Durgaiah, Ravisha Chikkamadaiah, Senthil Kumar, Amruta Joshi, Bharathi Sriram
Staphylococcus aureus (S.aureus) causes systemic infections with high morbidity and mortality and emergence of drug resistance strains are a rapidly growing clinical concerns. Novel therapeutic agents are required to tackle S.aureus infections. P128 is a bacteriophage-derived chimeric ectolysin with potent and rapid bactericidal activity on S. aureus In the current study, efficacy of P128 was evaluated in a newly-developed rat model of S. aureus bacteremia. Prior to in vivo testing, P128 was shown to be stable in whole blood by incubation in rat blood for up to 6 hrs and testing of its bactericidal activity against MRSA isolate USA 300...
November 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29176351/bacteremia-in-patients-with-liver-cirrhosis-prevalence-and-predictors-of-multidrug-resistant-organisms
#16
Jennifer N Addo Smith, Raymond Yau, Hannah P Russo, Kimberly Putney, Alejandro Restrepo, Kevin W Garey, Amelia K Sofjan
GOALS: The objective of this study was to assess the prevalence and predictors of multidrug resistant organisms (MDRO) in cirrhotic patients with bacteremia at a large tertiary center in the United States. BACKGROUND: The epidemiology of bacteremia in patients with liver cirrhosis has not been well studied in the United States. STUDY: This case-case control study included 180 adults with liver cirrhosis hospitalized from 2011 to 2015. Case group 1 were patients with bacteremia due to a MDRO (n=30)...
November 23, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29169153/optimal-trough-concentration-of-teicoplanin-in-febrile-neutropenic-patients-with-hematological-malignancy
#17
Yuhki Sato, Kazufumi Hiramatsu, Yosuke Suzuki, Ryota Tanaka, Tetsuya Kaneko, Ko Nonoshita, Masao Ogata, Jun-Ichi Kadota, Hiroki Itoh
BACKGROUND: Teicoplanin is a glycopeptide antibiotic currently used for the treatment of methicillin-resistant Staphylococcus aureus. The need for therapeutic drug monitoring of teicoplanin has been increasingly highlighted as important. It is generally accepted that whereas a plasma trough concentration (Cmin) of ≥10 mg/L is appropriate for the majority of infections, it should exceed 20 mg/L for severe infections. The target Cmin of teicoplanin in patients with febrile neutropenia (FN) has not been reported...
November 24, 2017: Chemotherapy
https://www.readbyqxmd.com/read/29163457/the-agr-quorum-sensing-system-represses-persister-formation-through-regulation-of-phenol-soluble-modulins-in-staphylococcus-aureus
#18
Tao Xu, Xu-Yang Wang, Peng Cui, Yu-Meng Zhang, Wen-Hong Zhang, Ying Zhang
The opportunistic pathogen Staphylococcus aureus has become an increasing threat to public health. While the Agr quorum sensing (QS) system is a master regulator of S. aureus virulence, its dysfunction has been frequently reported to promote bacteremia and mortality in clinical infections. Here we show that the Agr system is involved in persister formation in S. aureus. Mutation of either agrCA or agrD but not RNAIII resulted in increased persister formation of stationary phase cultures. RNA-seq analysis showed that in stationary phase AgrCA/AgrD and RNAIII mutants showed consistent up-regulation of virulence associated genes (lip and splE, etc...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29161942/trends-in-incidence-and-resistance-patterns-of-staphylococcus-aureus-bacteremia
#19
Elina Jokinen, Janne Laine, Reetta Huttunen, Outi Lyytikäinen, Risto Vuento, Jaana Vuopio, Jaana Syrjänen
BACKGROUND: Staphylococcus aureus bacteremia (SAB) causes a significant burden on the population. Several infection control measures have been implemented in Pirkanmaa county to combat a local epidemic with methicillin-resistant Staphylococcus aureus (MRSA). We aimed to study the epidemiology of SAB and antibiotic resistance of S. aureus and the possible influence of improved infection control. METHODS: Register data from 2005 to 2015 were retrospectively analysed to study the antimicrobial susceptibility, the incidence and mortality in SAB in a population-based setting...
January 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29156865/antibacterial-resistance-patterns-and-incidence-of-hospital-acquired-staphylococcus-aureus-bacteremia-in-a-tertiary-care-educational-hospital-in-turkey-a-perspective-from-2001-to-2013
#20
Oğuz Reşat Sipahi, Serhat Uysal, Sabire Şöhret Aydemir, Hüsnü Pullukçu, Meltem Taşbakan, Alper Tünger, Fatma Feriha Çilli, Tansu Yamazhan, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy
Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013. Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB...
August 23, 2017: Turkish Journal of Medical Sciences
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