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https://www.readbyqxmd.com/read/28677199/acne
#1
Klaus Degitz, Falk Ochsendorf
Acne is a chronic disease with a high prevalence among adolescents. Key pathogenetic factors (and their clinical correlates) are increased sebum production (seborrhea), follicular hyperkeratosis (comedones), and perifollicular inflammation (papules and pustules). The disease is modulated by a variety of endogenous (androgens, IGF-1, neuroendocrine factors) and exogenous (Propionibacterium acnes, diet, friction, ingredients of medical or cosmetic topical products) triggers. Acne is associated with high morbidity, and even mild manifestations may potentially cause considerable impairment in quality of life...
July 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28565799/phthiriasis-palpebrarum-a-case-of-eyelash-infestation-with-pthirus-pubis
#2
Na Wu, Hong Zhang, Feng Yuan Sun
Phthiriasis palpebrarum is a rare type of eyelid infestation. In the present study, a 63-year-old woman presented with a case of phthiriasis palpebrarum, which was initially misdiagnosed as anterior blepharitis. The patient had a 2-month history of repeated episodes of itching and burning sensations and moderate pain in both eyes that were not improved by antibiotic and corticosteroid eye drops. Slit lamp examination revealed lice and nits anchored to the eyelashes. All eyelashes were removed from the base along with lice and nits...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28560305/hydrocortisone-1-cream-and-sertaconazole-2-cream-to-treat-facial-seborrheic-dermatitis-a-double-blind-randomized-clinical-trial
#3
K Balighi, S Z Ghodsi, M Daneshpazhooh, S Ghale-Baghi, M Nasimi, A Azizpour
BACKGROUND: Seborrheic dermatitis (SD) is a chronic dermatitis with periods of remission and relapse that requires long-term treatment. OBJECTIVE: We compared the efficacy and safety of treatment with sertaconazole with standard corticosteroid medications in adults with facial SD. METHODS: In this double-blind, randomized controlled trial, 60 patients with a diagnosis of SD were enrolled. Patients were instructed to apply either sertaconazole 2% cream (30 patients) or hydrocortisone 1% cream (30 patients) twice daily to the affected area of the face...
June 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28463030/use-of-cyproterone-acetate-ethinylestradiol-in-polycystic-ovary-syndrome-rationale-and-practical-aspects
#4
X Ruan, A Kubba, A Aguilar, A O Mueck
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common, heterogeneous disorder characterised by hyperandrogenic skin symptoms, irregular menstruation and subfertility, increased risk of endometrial malignancy, and increased risk of preventable diseases associated with metabolic syndrome. Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 μg, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
June 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28458770/treatment-of-seborrheic-dermatitis-using-a-novel-herbal-based-cream
#5
Deganit Barak-Shinar, Ruben Del Río, Lawrence J Green
Objective: Seborrheic dermatitis is a common relapsing inflammatory skin condition occurring in approximately 3 to 5 percent of the general population. Current available therapies control, but do not cure seborrhea. The study's objective was to determine the safety and efficacy of a barrier-based, nonsteroidal cream incorporating herbal extracts as a treatment for facial seborrheic dermatitis. Design: Interventional, open label, safety/efficacy study. Setting: At the baseline visit, the investigator selected a target area on the face...
April 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28447864/the-use-of-cyproterone-acetate-ethinyl-estradiol-in-hyperandrogenic-skin-symptoms-a-review
#6
J Bitzer, T Römer, A Lopes da Silva Filho
INTRODUCTION: Hyperandrogenism affects approximately 10-20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Cyproterone acetate (CPA), combined with ethinylestradiol (EE), is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
June 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28405549/cutaneous-manifestations-of-polycystic-ovary-syndrome-a-cross-sectional-clinical-study
#7
Mohammad Abid Keen, Iffat Hassan Shah, Gousia Sheikh
BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS. AIM: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28253600/-genetic-analysis-of-a-pedigree-with-primary-hypertrophic-osteoarthropathy
#8
X G Liu, J Y Li, Y Bai, L X Zhang, X Wu, Y Y Ma, L J Chai, L L Zheng
Objective: To analyze the clinical and genetic features of primary hypertrophic osteoarthropathy (PHO). Methods: The clinical data of one Chinese pedigree of PHO, namely pachydermoperiostosis (PDP) were collected.Blood samples were drawn from the propositus and other family members.DNA was extracted and genetic analysis was performed by Sanger method after PCR.The sequencing data of HPGD gene exons were analyzed by alignment with sequences from National Center for Biotechnology Information (NCBI). Results: (1)The propositus represented symptoms in childhood including clubbing fingers, sweating, seborrhea, joint swelling and so on...
March 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28252627/-clinical-features-of-%C3%A2-metabolism%C3%A2-diseases-of-the-skin-in-patients-with-chronic-diffuse-liver-diseases
#9
O N Pozdnyakova, O B Nemchaninova, S G Lykova, T B Reshetnikova
AIM: To determine the clinical features of skin diseases developing in the presence of metabolic disturbances in patients with chronic diffuse liver diseases. SUBJECTS AND METHODS: A total of 368 patients with different clinical forms of hepatopathy were comprehensively examined. RESULTS: 817 cases of seborrhea, skin itch, xerodermia, xanthomatosis, and dyschromia were detected in 318 (86.4%) patients. CONCLUSION: The prevalence and intensity of cutaneous manifestations depended on the nature of the pathological liver process and indirectly testified to its severity and activity...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28225954/frequency-severity-and-related-factors-of-androgenetic-alopecia-in-dermatology-outpatient-clinic-hospital-based-cross-sectional-study-in-turkey
#10
Kubra Esen Salman, Ilknur Kivanc Altunay, Nihal Asli Kucukunal, Asli Aksu Cerman
BACKGROUND: Androgenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most common cause of hair loss in both genders. In recent years, many studies investigating the relation between systemic diseases and androgenetic alopecia presented controversial results. OBJECTIVES: In this study we aimed to investigate the frequency of androgenetic alopecia, the presence of accompanying systemic diseases, the relation between body mass index and androgenetic alopecia severity and the association of hyperandrogenemia signs with androgenetic alopecia in patients who referred to our outpatient clinic...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28135133/use-of-remote-cameras-to-monitor-the-potential-prevalence-of-sarcoptic-mange-in-southern-texas-usa
#11
Kyle Brewster, Scott E Henke, Clay Hilton, Alfonso Ortega-S
Sarcoptic mange, caused by the mite Sarcoptes scabiei , is a common, highly contagious skin disease that has been reported from more than 100 species of mammals, including humans. Our objectives were to 1) determine the prevalence of sarcoptic mange within mammals from southern Texas, and 2) determine the efficacy of using remote cameras to estimate mange prevalence. We collected remote camera photographs from a 64-km(2) area and blood and skin scrapings from 166 mammals representing 12 species in southern Texas, US during 2012-13...
April 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28081350/the-effect-of-systemic-isotretinoin-treatment-on-skin-biophysicalparameters-among-patients-with-acne-vulgaris
#12
Emine Çölgeçen, Kemal Özyurt, Ayten Ferahbaş Kesikoğlu
BACKGROUND/AIM: Systemic isotretinoin has been widely considered an effective and safe medical treatment for severe and refractory acne for nearly 3 decades. However, it also appears to cause undesirable cutaneous side effects. The aim of this study was to prospectively measure biophysical parameters of skin function among patients with acne vulgaris before and after 3 months of isotretinoin therapy, including pH, temperature, sebum content, skin hydration, and transepidermal water loss...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28060687/adult-acne-prevalence-and-portrayal-in-primary-healthcare-patients-in-the-greater-porto-area-portugal
#13
Diogo Semedo, Filipa Ladeiro, Mariana Ruivo, Carlos D'Oliveira, Filipa De Sousa, Mariana Gayo, Clara Lima, Frederico Magalhães, Rui Brandão, Maria Branco, Isabel Da Silva, Joana Batista, João Amado, António Massa, João Neves-Amado
INTRODUCTION: Though typically found in adolescents, acne frequently affects the adult population. In Portugal, no representative studies about acne prevalence in greater populational areas are known. This study had the following objectives: calculate acne prevalence in primary healthcare patients; its characteristics, including risk factors for onset and worsening; collect information concerning selfmedication and/or prescribed treatment. MATERIAL AND METHODS: Application of a questionnaire and physical examination into a convenience sample, composed by adults from20 - 60 years old that visited, in random days, five primary healthcare centers of the Greater Porto area...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27789243/proteomic-and-transcriptomic-investigation-of-acne-vulgaris-microcystic-and-papular-lesions-insights-in-the-understanding-of-its-pathophysiology
#14
Jusal Quanico, Jean-Pascal Gimeno, Florence Nadal-Wollbold, Christiane Casas, Sandrine Alvarez-Georges, Daniel Redoulès, Anne-Marie Schmitt, Isabelle Fournier, Michel Salzet
BACKGROUND: The pathogenesis of acne vulgaris involves several phases including androgen-dependent hyper-seborrhea, colonization by Propionibacterium acnes, and inflammation. Recent investigations have shown that in fact P. acnes provokes the activation of the inflammasome present in macrophages and dendritic cells. This signaling pathway leads to excessive production of interleukin IL-1β, a proinflammatory cytokine. Nevertheless, these well-studied phenomena in acne fail to elucidate the mechanisms responsible for the appearance of different lesions...
March 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27778328/low-dose-oral-isotretinoin-for-moderate-to-severe-seborrhea-and-seborrheic-dermatitis-a-randomized-comparative-trial
#15
RANDOMIZED CONTROLLED TRIAL
Cristhine de Souza Leão Kamamoto, Adriana Sanudo, Karime M Hassun, Ediléia Bagatin
BACKGROUND: The efficacy of low-dose oral isotretinoin in the treatment of seborrhea and seborrheic dermatitis has been poorly investigated in randomized studies. OBJECTIVES: This study was designed to determine the efficacy and safety of low-dose oral isotretinoin in the treatment of moderate to severe seborrhea and seborrheic dermatitis on the scalp and/or face. METHODS: A randomized, comparative clinical trial, using two groups, was conducted over 6 months...
January 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27113551/at-10-years-of-chlormadinone-use-in-latin-america-a-review
#16
REVIEW
Patricio Barriga P, Nicola Ambrosi Penazzo, Marta Franco Finotti, Alfredo A Celis, Oscar Cerdas, Jorge Armando Chávez, Luis Alfredo Cuitiño, César Eduardo Fernandes, Manuel Antonio Plata, José Tirán-Saucedo, Paula Sofía Vanhauwaert
Chlormadinone acetate (CMA) is a progesterone derivative (17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961. It was used as progestin-based hormone replacement therapy; since 1999 it was first used for oral contraception combined with ethinyl estradiol (EE). CMA exerts a potent progestagenic effect, about one third higher than that observed with endogenous progesterone. CMA is also an anti-estrogen, showing no androgenic effects (at birth control dose). Unlike progesterone, it has a mild glucosteroidal effect with no anti-mineralocorticoid effect at all...
July 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26868903/biofilm-production-and-antifungal-susceptibility-of-co-cultured-malassezia-pachydermatis-and-candida-parapsilosis-isolated-from-canine-seborrheic-dermatitis
#17
K Bumroongthai, P Chetanachan, W Niyomtham, C Yurayart, N Prapasarakul
The yeasts Malassezia (M.) pachydermatis and Candida (C.) parapsilosis are often co-isolated in case of canine seborrhea dermatitis (SD) and also are emerging as opportunistic pathogens of immunocompromised human beings. Increased information about how their relationship results in biofilm production and an antifungal response would be useful to inform treatment and control. This study was designed to investigate biofilm production derived from co-culture of M. pachydermatis and C. parapsilosis from dog skin and to determine their in vitro antifungal susceptibility...
July 1, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/26342835/possible-intermediary-role-of-ghrelin-in-seborrhea
#18
Zareie Elham, Agah Shahram, Sadeghpour Omid
Seborrhea, or oily skin, is a very common condition, especially among young people, caused by the increased secretion of sebum by sebaceous glands in the skin. Based on today's knowledge, a regulatory role of various hormones especially androgens is considered for sebaceous gland secretion; but despite significant evidences emphasis on the effects of the gastrointestinal disorders on coetaneous manifestations, the role of gastrointestinal problems in sebum secretion has not been emphasized yet. This study aimed to explain hormonal changes occurring in gastroesophageal reflux disease which may cause changes in sebaceous gland secretion so that, by explaining these communication mechanisms, common investigations between gastroenterology and dermatology can be performed to evaluate the accuracy of this hypothesis...
December 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/26333057/eccrine-porocarcinoma-shares-dermoscopic-characteristics-with-eccrine-poroma-a-report-of-three-cases-and-review-of-the-published-work
#19
REVIEW
Tomohiro Edamitsu, Akane Minagawa, Hiroshi Koga, Hisashi Uhara, Ryuhei Okuyama
Eccrine porocarcinoma (EPC) is a rare malignant skin tumor presumably arising from the intraepidermal ductal portion of the sweat gland. EPC occasionally mimics eccrine poroma (EP), seborrhea keratosis (SK), basal cell carcinoma (BCC), pyogenic granuloma (PG) and amelanotic melanoma with its clinical appearance as a pink nodule. Dermoscopy is an invaluable technique in diagnosing skin tumors. However, few cases of EPC have been reported using dermoscopic images, and their details were not well examined. Here, we present three histopathologically proven cases of EPC and summarize their dermoscopic findings together with five previously reported cases...
March 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/26288423/correlation-of-skin-changes-with-hormonal-changes-in-polycystic-ovarian-syndrome-a-cross-sectional-study-clinical-study
#20
B Vijaya Gowri, P L Chandravathi, P S Sindhu, K Shanthi Naidu
BACKGROUND: Polycystic ovarian syndrome (PCOS) is a heterogenous collection of signs and symptoms that when gathered, form a spectrum of disorder with disturbance of reproductive, endocrine and metabolic functions. AIM: The aim of this study is to correlate the skin manifestations with hormonal changes and to know the incidence and prevalence of skin manifestations in patients with PCOS. MATERIALS AND METHODS: A total of 40 patients with PCOS were examined during 1 year time period from May 2008 P to May 2009...
July 2015: Indian Journal of Dermatology
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