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resting leg syndrom

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https://www.readbyqxmd.com/read/29773202/impaired-short-term-plasticity-in-restless-legs-syndrome-a-pilot-rtms-study
#1
Giuseppe Lanza, Bartolo Lanuzza, Debora Aricò, Mariagiovanna Cantone, Filomena Irene Ilaria Cosentino, Rita Bella, Giovanni Pennisi, Raffaele Ferri, Manuela Pennisi
BACKGROUND: Previous studies showed an impairment of the LTP-like plasticity to TMS in restless legs syndrome (RLS). Clinically, repetitive TMS (rTMS) was effective in alleviating the sensory-motor complaints of patients, although the effects induced by low-frequency (inhibitory) rTMS have not yet been investigated. An impaired LTD-like mechanism of cortical plasticity has been hypothesized, which we have directly assessed in this pilot study. METHODS: Motor evoked potentials (MEPs) from the right first dorsal interosseus muscle were recorded at the stimulus intensity of 110% of the resting motor threshold (rMT) from 13 right-handed patients and ten age-matched right-handed healthy controls...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29702369/barefoot-plantar-pressure-measurement-in-chronic-exertional-compartment-syndrome
#2
D Roscoe, A J Roberts, D Hulse, A Shaheen, M P Hughes, A Bennett
BACKGROUND: Patients with Chronic Exertional Compartment Syndrome (CECS) have exercise-limiting pain that subsides at rest. Diagnosis is confirmed by intramuscular compartment pressure (IMCP) measurement. Accompanying CECS, subjective changes to gait (foot slap) are frequently reported by patients. This has not previously been investigated. The aim of this study was to investigate differences in barefoot plantar pressure (BFPP) between CECS cases and asymptomatic controls prior to the onset of painful symptoms...
April 9, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29680421/mapping-the-changed-hubs-and-corresponding-functional-connectivity-in-idiopathic-restless-legs-syndrome
#3
Chunyan Liu, Jiaojian Wang, Yue Hou, Zhigang Qi, Li Wang, Shuqin Zhan, Rong Wang, Yuping Wang
OBJECTIVE: The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS. METHODS: First, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects...
May 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29671490/common-running-injuries-evaluation-and-management
#4
Michael J Arnold, Aaron L Moody
Running is a common form of exercise but predisposes athletes to several running-related injuries. Most running injuries are due to overuse and respond to conservative treatment. Tendinopathies in the patellar, Achilles, and hamstring tendons are common, and are primarily treated with eccentric exercise. Iliotibial band syndrome and patellofemoral pain syndrome are less common than patellar tendinopathy and are treated by strengthening exercises for the core and legs in addition to flexibility exercises. Acute hamstring strains and medial tibial stress syndrome require a period of relative rest, followed by stretching and graded return to activity...
April 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29599693/functional-analysis-of-lower-limbs-in-individuals-infected-with-the-human-immunodeficiency-virus
#5
Gabriel Pádua da Silva, Bruno Ferreira, Selma Siéssere, Isabela Hallak Regalo, Danilo Stefani Esposto, Camila Roza Gonçalves, Veridiana Wanshi Arnoni, Edson Donizetti Verri, Paulo Batista Vasconcelos, Maria Aparecida Carneiro Vasconcelos, Alcyone Artioli Machado, Simone Cecilio Hallak Regalo
Objectives: The objective of this research was to analyze the functional changes of lower limbs by means of surface electromyography in patients with acquired immunodeficiency syndrome. Methods: A total of 60 men and women (age mean of 36.77 ± 9.33 years) were divided into two groups: 30 individuals with human immunodeficiency virus group (HIVG) Subtype 1 and 30 healthy individuals control group. Muscle activity was evaluated using surface electromyography (sEMG)...
March 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29554362/screening-for-idiopathic-rem-sleep-behavior-disorder-usefulness-of-actigraphy
#6
A Stefani, A Heidbreder, E Brandauer, M Guaita, L M Neier, T Mitterling, J Santamaria, A Iranzo, A Videnovic, C Trenkwalder, F Sixel-Döring, G K Wenning, A Chade, W Poewe, O S Gershanik, B Högl
Study objective: To evaluate the utility of multimodal low-cost approaches including actigraphy, a wrist-worn device monitoring rest/activity cycles, in identifying patients with idiopathic REM sleep behavior disorder (iRBD). Methods: Seventy patients diagnosed with sleep disorders causing different motor manifestations during sleep (iRBD, sleep apnea, restless legs syndrome) and 20 subjects without any relevant motor manifestation during sleep, underwent video-polysomnography (vPSG) and two-week actigraphy, completed six validated RBD screening questionnaires, and sleep apps use was assessed...
March 15, 2018: Sleep
https://www.readbyqxmd.com/read/29511386/clinical-and-electrophysiological-impact-of-repetitive-low-frequency-transcranial-magnetic-stimulation-on-the-sensory-motor-network-in-patients-with-restless-legs-syndrome
#7
Giuseppe Lanza, Mariagiovanna Cantone, Debora Aricò, Bartolo Lanuzza, Filomena Irene Ilaria Cosentino, Domenico Paci, Maurizio Papotto, Manuela Pennisi, Rita Bella, Giovanni Pennisi, Walter Paulus, Raffaele Ferri
Background: Based on the hyperexcitability and disinhibition observed in patients with restless legs syndrome (RLS) following transcranial magnetic stimulation (TMS), we conducted a study with low-frequency repetitive TMS (rTMS) over the primary motor (M1) and somatosensory cortical areas (S1) in patients with RLS. Methods: A total of 13 right-handed patients and 10 age-matched controls were studied using clinical scales and TMS. Measurements included resting motor threshold (rMT), motor-evoked potentials (MEPs), cortical silent period (CSP), and central motor conduction time (CMCT)...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29441041/altered-brain-functional-connectome-in-migraine-with-and-without-restless-legs-syndrome-a-resting-state-functional-mri-study
#8
Fu-Chi Yang, Kun-Hsien Chou, Ai-Ling Hsu, Jong-Ling Fuh, Jiing-Feng Lirng, Hung-Wen Kao, Ching-Po Lin, Shuu-Jiun Wang
Background: Migraine is frequently comorbid with restless legs syndrome (RLS), both displaying functional connectivity (FC) alterations in multiple brain networks, although the neurological basis of this association is unknown. Methods: We performed resting-state functional magnetic resonance imaging and network-wise analysis of FC in migraine patients with and without RLS and healthy controls (CRL). Network-based statistics (NBS) and composite FC matrix analyses were performed to identify the patterns of FC changes...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29297976/platelet-responses-to-pharmacological-and-physiological-interventions-in-middle-aged-men-with-different-habitual-physical-activity-levels
#9
M H Lundberg Slingsby, L Gliemann, M Thrane, N Rytter, J Egelund, M V Chan, P C Armstrong, T D Warner, Y Hellsten
The current guidelines following an acute coronary syndrome recommend dual-antiplatelet therapy (DAPT) (aspirin plus a P2Y12 antagonist) alongside lifestyle modifications, including more regular physical activity. It is currently unknown whether regular exercise affects the pharmacology of DAPT. AIM: To explore how exercise-induced improvements in vascular and platelet function affect the efficacy of DAPT, in a cross-sectional study of men with different physical activity levels (training status)...
January 3, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29234958/the-relationship-between-putamen-sma-functional-connectivity-and-sensorimotor-abnormality-in-esrd-patients
#10
Dun Ding, Peng Li, Xue-Ying Ma, Wang-Huan Dun, Shi-Feng Yang, Shao-Hui Ma, Hong-Juan Liu, Ming Zhang
The basal ganglia (BG) are composed of several nuclei involved in neural processing associated with integration of sensory and motor information. Recent neuroimaging studies implicated its key role in control of voluntary motor function. As the sensorimotor abnormality is common among the end-stage renal disease (ESRD) population, in the current study, we aimed to investigate the abnormal structure and functional connectivity patterns of BG in ESRD patients. Twenty-nine ESRD and twenty-nine age and gender-matched healthy controls (HC) were enrolled to compare the volume of the subsets in the BG (e...
December 12, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29172115/rls-patients-show-better-nocturnal-performance-in-the-simon-task-due-to-diminished-visuo-motor-priming
#11
Rui Zhang, Wiebke Schrempf, Moritz D Brandt, Moritz Mückschel, Christian Beste, Ann-Kathrin Stock
OBJECTIVE: The restless legs syndrome (RLS) is characterized by sensory-motor symptoms which usually occur predominantly at rest in the evening and at night. It is assumed that this circadian rhythm is caused by low dopamine levels in the evening. Yet, it has never been investigated whether RLS patients show diurnal variations in cognitive functions modulated by dopamine and what neurophysiological and functional neuroanatomical processes underlie such modulations. METHODS: We used a Simon task combined with EEG and source localization to investigate whether top-down response selection and/or automatic visuo-motor priming are subject to diurnal changes in RLS patients, as compared to matched healthy controls...
January 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29097554/restless-legs-syndrome-clinical-features-diagnosis-and-a-practical-approach-to-management
#12
REVIEW
Subhashie Wijemanne, William Ondo
Restless legs syndrome (RLS) is a chronic neurological disorder that interferes with rest and sleep. It has a wide spectrum of symptom severity, and treatment is started when symptoms become bothersome. Dopamine agonists and calcium channel apha-2-delta antagonists (gabapentin, gabapentin enacarbil and pregabalin) are first-line treatments; calcium channel alpha-2-deltas are preferred over dopamine agonists because they give less augmentation, a condition with symptom onset earlier in the day and intensification of RLS symptoms...
December 2017: Practical Neurology
https://www.readbyqxmd.com/read/29059243/muscle-oxygenation-in-type-1-diabetic-and-non-diabetic-patients-with-and-without-chronic-compartment-syndrome
#13
Patrik Gustafsson, Albert G Crenshaw, David Edmundsson, Göran Toolanen, Sead Crnalic
BACKGROUND: Type 1 diabetic patients and non-diabetic patients were referred for evaluation for chronic exertional compartment syndrome (CECS) based on clinical examination and complaints of activity-related leg pain in the region of the tibialis anterior muscle. Previous studies using near-infrared spectroscopy (NIRS) showed greater deoxygenation during exercise for CECS patients versus healthy controls; however, this comparison has not been done for diabetic CECS patients. METHODS: We used NIRS to test for differences in oxygenation kinetics for Type 1 diabetic patients diagnosed with (CECS-diabetics, n = 9) versus diabetic patients without (CON-diabetics, n = 10) leg anterior chronic exertional compartment syndrome...
2017: PloS One
https://www.readbyqxmd.com/read/29042004/quantitative-functional-mri-and-neurophysiological-markers-in-a-case-of-gerstmann-str%C3%A3-ussler-scheinker-syndrome
#14
Silvia Marino, Rosa Morabito, S De Salvo, L Bonanno, A Bramanti, P Pollicino, R Giorgianni, Placido Bramanti
Gerstmann-Sträussler-Scheinker syndrome (GSS) is an inherited autosomal dominant prion disease, caused by a codon 102 proline to leucine substitution (P102L) in the prion protein gene (PRNP). We describe the case of a 40-year-old male, affected by a slowly progressive gait disturbance, leg weakness and cognitive impairment. Genomic DNA revealed a point mutation of PRNP at codon 102, resulting in P102L, and the diagnosis of GSS was confirmed. Somatosensory evoked potentials showed alterations of principal parameters, particularly in the right upper and lower limbs...
July 2017: Functional Neurology
https://www.readbyqxmd.com/read/29031764/combined-resting-state-functional-magnetic-resonance-imaging-and-diffusion-tensor-imaging-study-in-patients-with-idiopathic-restless-legs-syndrome
#15
Yaoyao Zhuo, Yuncheng Wu, Yanhong Xu, Lunbo Lu, Ting Li, Xifu Wang, Kangan Li
OBJECTIVE: Restless legs syndrome (RLS) is a common neurological disorder characterized by an urge to move the legs along with paraesthesia deep within them. In this study, we aimed to use diffusion tensor imaging (DTI) and regional homogeneity (ReHo) to investigate the changes in regional spontaneous brain activity change for RLS patients against age- and gender-matched normal control (NC) subjects. METHODS: A total of 35 RLS patients and 27 age- and gender-matched NC subjects were recruited for group comparison research that used DTI and ReHo techniques...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29027398/nutritional-status-cachexia-and-anorexia-in-women-with-peritoneal-metastasis-and-intraperitoneal-chemotherapy-a-longitudinal-analysis
#16
Ziad Hilal, Günther A Rezniczek, Robert Klenke, Askin Dogan, Clemens B Tempfer
OBJECTIVE: To describe the nutritional status of women with peritoneal metastasis (PM) from recurrent ovarian, fallopian, or peritoneal cancer and to assess longitudinal variations of the cachexia-anorexia syndrome (CAS) during palliative pressurized intraperitoneal aerosol chemotherapy (PIPAC). METHODS: Nutritional assessment included body mass index (BMI), bioelectrical impedance analysis (BIA), and blood chemistry. CAS presence/absence was recorded before and during repeated cycles (1-11) of PIPAC...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28985544/spasticity-and-spastic-dystonia-the-two-faces-of-velocity-dependent-hypertonia
#17
Lucio Marinelli, Antonio Currà, Carlo Trompetto, Elisabetta Capello, Carlo Serrati, Francesco Fattapposta, Elisa Pelosin, Chetan Phadke, Claire Aymard, Luca Puce, Franco Molteni, Giovanni Abbruzzese, Fabio Bandini
BACKGROUND: Spasticity and spastic dystonia are two separate phenomena of the upper motor neuron syndrome. Spasticity is clinically defined by velocity-dependent hypertonia and tendon jerk hyperreflexia due to the hyper-excitability of the stretch reflex. Spastic dystonia is the inability to relax a muscle leading to a spontaneous tonic contraction. Both spasticity and spastic dystonia are present in patients who are at rest; however, only patients with spasticity are actually able to kept their muscles relaxed prior to muscle stretch...
December 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28950030/compression-therapy-for-prevention-of-post-thrombotic-syndrome
#18
REVIEW
Diebrecht Appelen, Eva van Loo, Martin H Prins, Martino Ham Neumann, Dinanda N Kolbach
BACKGROUND: Post-thrombotic syndrome (PTS) is a long-term complication of deep vein thrombosis (DVT) that is characterised by chronic pain, swelling, and skin changes in the affected limb. One of every three people with DVT will develop post-thrombotic complications within five years. Several non-pharmaceutical measures are used for prevention of post-thrombotic syndrome during the acute phase of DVT. These include elevation of the legs and compression therapy. Clinicians and guidelines differ in their assessment of the utility of compression therapy for treatment of DVT...
September 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28899286/restless-legs-syndrome-related-to-hemorrhage-of-a-thoracic-spinal-cord-cavernoma
#19
Malik Hamdaoui, Elisabeth Ruppert, Henri Comtet, Ulker Kilic-Huck, Valérie Wolff, Marc Bataillard, Patrice Bourgin
CONTEXT: Restless legs syndrome (RLS) is a common neurological disorder characterized by an irresistible urge to move the lower limbs often accompanied by unpleasant sensations in the legs, worsened at rest and in the evening. Symptoms are improved by movement. Its pathophysiology remains poorly understood. Lesion-related RLS has been reported, mainly in cases of stroke-related RLS involving the brainstem and lenticulostriate nuclei. Only few data of RLS in a context of spinal cord injury have been reported...
March 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28842109/treatment-of-medial-tibial-stress-syndrome-with-radial-soundwave-therapy-in-elite-athletes-current-evidence-report-on-two-cases-and-proposed-treatment-regimen
#20
Amol Saxena, Brian Fullem, Ludger Gerdesmeyer
Two case reports of high-level athletes with medial tibial stress syndrome (MTSS), 1 an Olympian with an actual stress fracture, are presented. Successful treatment included radial soundwave therapy, pneumatic leg braces, relative rest using an antigravity treadmill, and temporary foot orthoses. Radial soundwave therapy has a high level of evidence for treatment of MTSS. We also present recent evidence of the value of vitamin D assessment. Both patients had a successful outcome with minimal downtime. Finally, a suggested treatment regimen for MTSS is presented...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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