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intralesional PPD for wart

Vikrant Saoji, Nitin R Lade, Rutuja Gadegone, Arun Bhat
BACKGROUND: Warts are known to clear spontaneously with the development of cell-mediated immunity (CMI) to the virus. Purified protein derivative (PPD) of tuberculin bacilli has been used as a non-specific stimulant of CMI to achieve this outcome. AIM: To study the effect of PPD in the treatment of warts. METHODS: Patients with difficult to treat warts were selected for immunotherapy. Each patient received 2.5 TU of PPD intralesionally in a few warts...
December 14, 2015: Indian Journal of Dermatology, Venereology and Leprology
Mehdi Amirnia, Effat Khodaeiani, Daniel F Fouladi, Sima Masoudnia
BACKGROUND: Due to paucity of randomized clinical trials, intralesional immunotherapy has not been yet accepted as a standard therapeutic method. OBJECTIVE: To examine the efficacy and safety of intralesional immunotherapy with tuberculin purified protein derivative (PPD) for treating recalcitrant wart. METHODS: In this randomized, placebo-controlled, double-blind clinical trial, a total of 69 patients with recalcitrant warts received either intralesional PPD antigen (nā€‰=ā€‰35) or intralesional saline (nā€‰=ā€‰34) for six times at 2-week intervals...
2016: Journal of Dermatological Treatment
Fian M A Abd-Elazeim, Ghada F A Mohammed, Amal Fathy, Roshdy W Mohamed
BACKGROUND: No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW). OBJECTIVE: To evaluate the immunological mechanisms and clinical therapeutic effect of using of intralesional purified protein derivative (PPD) in the treatment of RMCW. METHODS: The study included 40 patients with RMCW. They were randomly assigned to 2 groups: first group (20 patients) received intralesional PPD antigen, and second group (20 patients) received intralesional saline as a control group...
June 2014: Journal of Dermatological Treatment
Bayoumy I Eassa, Amany A Abou-Bakr, Mohamed A El-Khalawany
Immunotherapy for treatment of recalcitrant warts was used through different modalities including intralesional injection of purified protein derivative (PPD), which is an extract of Mycobacterium tuberculosis, used for testing exposure to tuberculin protein, either from a previous vaccination or from the environment. This method is used to evaluate the efficacy of a new approach of intradermal injection of PPD in the treatment of anogenital warts in pregnant women. A total of 40 pregnant women, aged 20-35 years, and presented with anogenital warts were enrolled in this study...
January 2011: Dermatologic Therapy
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