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reduced heart rate variability and mortality

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https://www.readbyqxmd.com/read/29248699/machine-learning-ensemble-modelling-to-classify-caesarean-section-and-vaginal-delivery-types-using-cardiotocography-traces
#1
Paul Fergus, Malarvizhi Selvaraj, Carl Chalmers
Human visual inspection of Cardiotocography traces is used to monitor the foetus during labour and avoid neonatal mortality and morbidity. The problem, however, is that visual interpretation of Cardiotocography traces is subject to high inter and intra observer variability. Incorrect decisions, caused by miss-interpretation, can lead to adverse perinatal outcomes and in severe cases death. This study presents a review of human Cardiotocography trace interpretation and argues that machine learning, used as a decision support system by obstetricians and midwives, may provide an objective measure alongside normal practices...
December 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29236747/a-meta-analysis-of-effects-of-post-hatch-food-and-water-deprivation-on-development-performance-and-welfare-of-chickens
#2
Ingrid C de Jong, Johan van Riel, Marc B M Bracke, Henry van den Brand
A 'meta-analysis' was performed to determine effects of post-hatch food and water deprivation (PHFWD) on chicken development, performance and welfare (including health). Two types of meta-analysis were performed on peer-reviewed scientific publications: a quantitative 'meta-analysis' (MA) and a qualitative analysis (QA). Previously reported effects of PHFWD were quantified in the MA, for variables related to performance, mortality and relative yolk sac weight. The QA counted the number of studies reporting (non-)significant effects when five or more records were available in the data set (i...
2017: PloS One
https://www.readbyqxmd.com/read/29217881/reduced-baroreflex-sensitivity-decreased-heart-rate-variability-with-increased-arterial-stiffness-in-predialysis
#3
C Lal, M Kaur, A K Jaryal, K K Deepak, D Bhowmik, S K Agarwal
High cardiovascular morbidity and mortality is observed in predialytic chronic kidney disease (CKD) patients. The underlying mechanism of cardiovascular dysfunction often remains unclear. The present study was designed to perform multiparametric assessment of baroreflex sensitivity (BRS), arterial stiffness indices, and cardiovascular variabilities (heart rate variability [HRV] and blood pressure variability [BPV]) together in predialytic CKD patients; compare it with normal healthy controls; and determine their relationships in predialytic nondiabetic CKD patients...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29214181/cardiac-autonomic-neuropathy-why-should-cardiologists-care-about-that
#4
REVIEW
Andrzej Bissinger
Background: Cardiac autonomic neuropathy (CAN) is a frequent but underdiagnosed complication of diabetes mellitus. It has a strong influence on various cardiac disorders including myocardial ischemia and infarction, hypertension, orthostatic hypotonia, heart failure, and arrhythmias. CAN can lead to severe morbidity and mortality and increase the risk of sudden cardiac death. Methods: This review article summarizes the latest evidence regarding the epidemiology, pathogenesis, influence on the cardiovascular system, and diagnostic methods for CAN...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29195726/cardiovascular-effects-of-oral-appliance-therapy-in-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#5
REVIEW
Grietje E de Vries, Peter J Wijkstra, Ewout J Houwerzijl, Huib A M Kerstjens, Aarnoud Hoekema
Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality. This study systematically reviews the effects of oral appliance therapy (OAT) on a broad spectrum of cardiovascular outcomes. A literature search was performed up to December 31st 2016. Twenty-five relevant full-text articles were retrieved. Sixteen articles were considered methodologically sufficient, including 11 randomized controlled trials. Pooled data of the RCTs showed significant reductions in daytime systolic and diastolic blood pressure compared to baseline, but no significant reductions in heart rate, except for daytime heart rate when compared to inactive/placebo OAT...
October 26, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29193563/sacubitril-valsartan-reduces-serum-uric-acid-concentration-an-independent-predictor-of-adverse-outcomes-in-paradigm-hf
#6
Ulrik M Mogensen, Lars Køber, Pardeep S Jhund, Akshay S Desai, Michele Senni, Søren L Kristensen, Andrej Dukát, Chen-Huan Chen, Felix Ramires, Martin P Lefkowitz, Margaret F Prescott, Victor C Shi, Jean L Rouleau, Scott D Solomon, Karl Swedberg, Milton Packer, John J V McMurray
AIMS: Elevated serum uric acid concentration (SUA) has been associated with an increased risk of cardiovascular disease, but this may be due to unmeasured confounders. We examined the association between SUA and outcomes as well as the effect of sacubitril/valsartan on SUA in patients with heart failure with reduced ejection fraction (HFrEF) in PARADIGM-HF. METHODS AND RESULTS: The association between SUA and the primary composite outcome of cardiovascular death or heart failure (HF) hospitalization, its components, and all-cause mortality was examined using Cox regression analyses among 8213 patients using quintiles (Q1-Q5) of SUA adjusted for baseline prognostic variables including estimated glomerular filtration rate (eGFR), diuretic dose, and log N-terminal pro-brain natriuretic peptide...
November 30, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29121716/risk-prediction-in-post-infarction-patients-with-moderately-reduced-left-ventricular-ejection-fraction-by-combined-assessment-of-the-sympathetic-and-vagal-cardiac-autonomic-nervous-system
#7
W Hamm, L Stülpnagel, N Vdovin, G Schmidt, K D Rizas, A Bauer
AIM: Most deaths after myocardial infarction (MI) occur in patients with normal or moderately reduced left ventricular ejection fraction (LVEF >35%). Periodic repolarization dynamics (PRD) and deceleration capacity (DC) are novel ECG-based markers related to sympathetic and vagal cardiac autonomic nervous system activity. Here, we test the combination of PRD and DC to predict risk in post-infarction patients with LVEF >35%. METHODS AND RESULTS: We included 823 survivors of acute MI with LVEF >35%, aged ≤80years and in sinus rhythm...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29108934/cardiovascular-control-is-associated-with-pair-bond-success-in-male-prairie-voles
#8
Robert Lewis, Brek Wilkins, Bruce Benjamin, J Thomas Curtis
Social support structures reduce mortality and morbidity in humans, but the mechanisms underlying these reductions are not fully understood. The prevailing hypothesis is that social support buffers stress and reduces allostatic load, thereby increasing longevity. However, the possibility that affiliative social interactions confer health benefits independent of stress buffering is understudied. We examined autonomic function in prairie voles - arguably the premier species for modeling human social affiliation - to assess the possibility that the formation of strong social bonds alters autonomic function and contributes to health benefits...
October 2, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29089343/impact-of-atrial-fibrillation-on-exercise-capacity-and-mortality-in-heart-failure-with-preserved-ejection-fraction-insights-from-cardiopulmonary-stress-testing
#9
Mohamed B Elshazly, Todd Senn, Yuping Wu, Bruce Lindsay, Walid Saliba, Oussama Wazni, Leslie Cho
BACKGROUND: Atrial fibrillation (AF) has been objectively associated with exercise intolerance in patients with heart failure with reduced ejection fraction; however, its impact in patients with heart failure with preserved ejection fraction has not been fully scrutinized. METHODS AND RESULTS: We identified 1744 patients with heart failure and ejection fraction ≥50% referred for cardiopulmonary stress testing at the Cleveland Clinic (Cleveland, OH), 239 of whom had AF...
October 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29081000/association-between-medicare-s-mandatory-hospital-value-based-purchasing-program-and-cost-inefficiency
#10
Germán M Izón, Chelsea A Pardini
BACKGROUND: The Patient Protection and Affordable Care Act instituted pay-for-performance programs, including Hospital Value-Based Purchasing (HVBP), designed to encourage hospital quality and efficiency. OBJECTIVE AND METHOD: While these programs have been evaluated with respect to their implications for care quality and financial viability, this is the first study to assess the relationship between hospitals' cost inefficiency and their participation in the programs...
October 28, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29049838/predicting-long-term-survival-after-coronary-artery-bypass-graft-surgery
#11
Md N Karim, Christopher M Reid, Mollah Huq, Samuel L Brilleman, Andrew Cochrane, Lavinia Tran, Baki Billah
OBJECTIVES: To develop a model for predicting long-term survival following coronary artery bypass graft surgery. METHODS: This study included 46 573 patients from the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZCTS) registry, who underwent isolated coronary artery bypass graft surgery between 2001 and 2014. Data were randomly split into development (23 282) and validation (23 291) samples. Cox regression models were fitted separately, using the important preoperative variables, for 4 'time intervals' (31-90 days, 91-365 days, 1-3 years and >3 years), with optimal predictors selected using the bootstrap bagging technique...
October 6, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29023738/klf2-mediates-enhanced-chemoreflex-sensitivity-disordered-breathing-and-autonomic-dysregulation-in-heart-failure
#12
Noah J Marcus, Rodrigo Del Rio, Yanfeng Ding, Harold D Schultz
KEY POINTS: Enhanced carotid body chemoreflex activity contributes to development of disordered breathing patterns, autonomic dysregulation and increases in incidence of arrhythmia in animal models of reduced ejection fraction heart failure. Chronic reductions in carotid artery blood flow are associated with increased carotid body chemoreceptor activity. Krüppel-like Factor 2 (KLF2) is a shear stress-sensitive transcription factor that regulates the expression of enzymes which have previously been shown to play a role in increased chemoreflex sensitivity...
September 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29018174/prognostic-value-of-n-terminal-pro-b-type-natriuretic-peptide-levels-in-heart-failure-patients-with-and-without-atrial-fibrillation
#13
Søren Lund Kristensen, Pardeep S Jhund, Ulrik M Mogensen, Rasmus Rørth, William T Abraham, Akshay Desai, Kenneth Dickstein, Jean L Rouleau, Michael R Zile, Karl Swedberg, Milton Packer, Scott D Solomon, Lars Køber, John J V McMurray
BACKGROUND: Patients with heart failure (HF) and atrial fibrillation (AF) have higher circulating levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) than HF patients without AF. There is uncertainty about the prognostic importance of a given concentration of NT-proBNP in HF patients with and without AF. We investigated this question in a large cohort of patients with HF and reduced ejection fraction. METHODS AND RESULTS: We studied 14 737 patients with HF and reduced ejection fraction and a measurement of NT-proBNP at time of screening, enrolled in either the PARADIGM-HF trial (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) or the ATMOSPHERE trial (Aliskiren Trial to Minimize Outcomes in Patients With Heart Failure), of whom 3575 (24%) had AF on their baseline ECG...
October 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28970660/an-appraisal-of-mortality-in-intensive-care-unit-of-a-level-iii-military-hospital-of-bangladesh
#14
Md Rabiul Alam, Mainul Haque, Mozibul Haque
BACKGROUND: Mortalities in Intensive Care Units (ICUs) are high and widely variable. The unpredictability of death rates is attributable to age, sex, nature and severity of illness, comorbidity, well-timed medical attention, quality of the attending staffs, iatrogenic events, total management facilities, and overall grade of the ICU in general. MATERIALS AND METHODS: A total of seventy patients who died in the ICU of a Level III Combined Military Hospital within a period of 2 years were studied in retrospect to review the mortality pattern...
September 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28964157/sign-and-magnitude-scaling-properties-of-heart-rate-variability-in-patients-with-end-stage-renal-failure-are-these-properties-useful-to-identify-pathophysiological-adaptations
#15
Claudia Lerma, Juan C Echeverría, Oscar Infante, Héctor Pérez-Grovas, Hortensia González-Gómez
The scaling properties of heart rate variability data are reliable dynamical features to predict mortality and for the assessment of cardiovascular risk. The aim of this manuscript was to determine if the scaling properties, as provided by the sign and magnitude analysis, can be used to differentiate between pathological changes and those adaptations basically introduced by modifications of the mean heart rate in distinct manoeuvres (active standing or hemodialysis treatment, HD), as well as clinical conditions (end stage renal disease, ESRD)...
September 2017: Chaos
https://www.readbyqxmd.com/read/28954496/territorial-variation-in-mortality-from-causes-amenable-to-medical-care-in-poland
#16
Wiktoria Wróblewska
INTRODUCTION AND OBJECTIVE: This study examines the geographical variation of amenable mortality in Poland, focusing primarily on the role of health care resources at the level of administrative districts and regions, and selected area socioeconomic characteristics as explanatory factors. The concept was used of amenable mortality, based on the assumption that deaths from certain causes should not occur in the presence of timely and effective health care. MATERIAL AND METHODS: Standardized death rates (SDR) from causes considered amenable to health care and, separately, for ischaemic heart disease (IHD), were calculated for each of 379 districts (NUTS 4 level) in Poland in 1991-1995 and 2006-2010, using unit mortality data from the National Causes of Death Register...
September 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28942507/physical-exercise-improves-heart-rate-variability-in-patients-with-type-2-diabetes-a-systematic-review
#17
REVIEW
Santos Villafaina, Daniel Collado-Mateo, Juan Pedro Fuentes, Eugenio Merellano-Navarro, Narcis Gusi
PURPOSE OF REVIEW: The aim of the present systematic review is to provide an up-to-date analysis of the research on the effects of exercise programs on heart rate variability (HRV) in individuals with type 2 diabetes mellitus (T2DM). An electronic search of the literature (PubMed, PEDro and Web of Science) was performed. "HRV", "heart rate variability", "exercise", "physical" and "diabetes" were the terms used for article retrieval. Lastly, 15 articles were selected. PRISMA methodology was employed and data were extracted according to the PICOS approach...
September 23, 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28941750/is-30-day-mortality-after-admission-for-heart-failure-an-appropriate-metric-for-quality
#18
Robert T Faillace, Gregory W Yost, Yashasvi Chugh, Jeffrey Adams, Beni R Verma, Zaid Said, Ibrahim Ismail Sayed, Ashley Honushefsky, Sanjay Doddamani, Peter B Berger
BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) model for publicly reporting national 30-day-risk-adjusted mortality rates for patients admitted with heart failure fails to include clinical variables known to impact total mortality or take into consideration the culture of end-of-life care. We sought to determine if those variables were related to the 30-day mortality of heart failure patients at Geisinger Medical Center. METHODS: Electronic records were searched for patients with a diagnosis of heart failure who died from any cause during hospitalization or within 30-days of admission...
September 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28855119/the-effects-of-fluctuating-temperature-regimes-on-the-embryonic-development-of-lake-whitefish-coregonus-clupeaformis
#19
Michael Y-T Lim, Richard G Manzon, Christopher M Somers, Douglas R Boreham, Joanna Y Wilson
Fluctuating incubation temperatures may have significant effects on fish embryogenesis; yet most laboratory-based studies use constant temperatures. For species that experience large, natural seasonal temperature changes during embryogenesis, such as lake whitefish (Coregonus clupeaformis), seasonal temperature regimes are likely optimal for development. Anthropogenic activities can increase average and/or variability of natural incubation temperatures over large (e.g. through climate change) or smaller (e...
December 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28831544/-non-device-based-telemonitoring-toy-or-tool
#20
REVIEW
Martin Stockburger
Non-device-based telemedical management can be useful to prevent decompensation and death in patients suffering from easily disequilibrated conditions like diabetes mellitus, chronic obstructive pulmonary disease and heart failure (HF). This article summarizes current knowledge on non-device-based telemedical care for patients with HF. Several parameters (heart rate, heart rate variability, systolic blood pressure, pulse pressure, body weight, physical activity as derived from accelerometry, and occurrence of atrial and ventricular arrhythmias) have been identified as being associated with imminent clinical deterioration of HF patients...
September 2017: Herzschrittmachertherapie & Elektrophysiologie
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