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https://www.readbyqxmd.com/read/29050102/-research-progress-on-the-etiology-of-delayed-onset-hearing-loss-in-children
#1
X Y Wang, L H Huang, Y T Du
Newborn hearing screening is an effective method for early detection of hearing loss, however, it is not able to detect delayed-onset hearing loss. By exploring the etiology of delayed-onset hearing loss in children, it can provide a clinical basis for early detection of delayed-onset hearing loss. Mutations in SLC26A4, mitochondrial, GJB2 and other genes, enlarged vestibular aqueduct, congenital cytomegalovirus infection, extracorporeal membrane oxygenation, and auditory neuropathy et al were more commonly reported risk factors...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29049998/endoplasmic-reticulum-stress-is-involved-in-cochlear-cell-apoptosis-in-a-cisplatin-induced-ototoxicity-rat-model
#2
Shimin Zong, Tianyi Liu, Fangmin Wan, Pei Chen, Pan Luo, Hongjun Xiao
Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When ER stress occurs, the unfolded protein response (UPR) is subsequently activated to restore ER proteostasis. However, severe ER stress leads to apoptosis. Recent studies have suggested that cisplatin cytotoxicity may be related to ER stress. The purpose of this study was to determine whether ER stress participates in cochlear cell apoptosis in a cisplatin-induced ototoxicity rat model and to also determine the possible relationship between ER stress and hearing loss...
October 20, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29049629/do-older-listeners-with-hearing-loss-benefit-from-dynamic-pitch-for-speech-recognition-in-noise
#3
Jing Shen, Pamela E Souza
Purpose: Dynamic pitch, the variation in the fundamental frequency of speech, aids older listeners' speech perception in noise. It is unclear, however, whether some older listeners with hearing loss benefit from strengthened dynamic pitch cues for recognizing speech in certain noise scenarios and how this relative benefit may be associated with individual factors. We first examined older individuals' relative benefit between natural and strong dynamic pitches for better speech recognition in noise...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049628/findings-from-eurotrak-surveys-from-2009-to-2015-hearing-loss-prevalence-hearing-aid-adoption-and-benefits-of-hearing-aid-use
#4
Nikolai Bisgaard, Stefan Ruf
Purpose: The purpose of this study was to analyze data from the EuroTrak surveys performed from 2009 to 2015 in Germany, France, and the United Kingdom to identify factors that could account for the growth in hearing aid sales over that period. Method: Data of 132,028 people-approximately 15,000 for each of the 3 countries at 3-year intervals-were collected using a questionnaire. The sample in each country was weighted using the respective country age-gender populations to get balanced results...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049627/international-outcome-inventory-for-hearing-aids-data-from-a-large-swedish-quality-register-database
#5
Stig Arlinger, Peter Nordqvist, Marie Öberg
Purpose: The purpose of this study was to analyze a database of completed International Outcome Inventory for Hearing Aids (IOI-HA) questionnaires obtained from over 100,000 clients fitted with new hearing aids in Sweden during the period of 2012-2016. Mean IOI-HA total scores were correlated with degree of hearing loss, unilateral versus bilateral fitting, first-time versus return clients, gender, and variation among dispensing clinics. The correlations with expectations, service quality, and technical functioning of the hearing aids were also analyzed...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049623/subjective-fatigue-in-children-with-hearing-loss-assessed-using-self-and-parent-proxy-report
#6
Benjamin W Y Hornsby, Samantha J Gustafson, Hope Lancaster, Sun-Joo Cho, Stephen Camarata, Fred H Bess
Purpose: The primary purposes of this study were to examine the effects of hearing loss and respondent type (self- vs. parent-proxy report) on subjective fatigue in children. We also examined associations between child-specific factors and fatigue ratings. Method: Subjective fatigue was assessed using the Pediatric Quality of Life Inventory Multidimensional Fatigue Scale (PedsQL-MFS; Varni, Burwinkle, Katz, Meeske, & Dickinson, 2002). We compared self- and parent-proxy ratings from 60 children with hearing loss (CHL) and 43 children with normal hearing (CNH)...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049621/autonomic-nervous-system-responses-to-hearing-related-demand-and-evaluative-threat
#7
Carol L Mackersie, Lucia Kearney
Purpose: This paper consists of 2 parts. The purpose of Part 1 was to review the potential influence of internal (person-related) factors on listening effort. The purpose of Part 2 was to present, in support of Part 1, preliminary data illustrating the interactive effects of an external factor (task demand) and an internal factor (evaluative threat) on autonomic nervous system measures. Method: For Part 1, we provided a brief narrative review of motivation and stress as modulators of listening effort...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049619/field-monitoring-of-otoacoustic-emissions-during-noise-exposure-pilot-study-in-controlled-environment
#8
Vincent Nadon, Annelies Bockstael, Dick Botteldooren, Jérémie Voix
Purpose: In spite of all the efforts to implement workplace hearing conservation programs, noise-induced hearing loss remains the leading cause of disability for North American workers. Nonetheless, an individual's susceptibility to noise-induced hearing loss can be estimated by monitoring changes in hearing status in relation to the level of ambient noise exposure. The purpose of this study was to validate an approach that could improve workplace hearing conservation practices. The approach was developed using a portable and robust system designed for noisy environments and consisted of taking continuous measurements with high temporal resolution of the health status of the inner ear using otoacoustic emissions (OAEs)...
October 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29049603/enhancing-auditory-selective-attention-using-a-visually-guided-hearing-aid
#9
Gerald Kidd
Purpose: Listeners with hearing loss, as well as many listeners with clinically normal hearing, often experience great difficulty segregating talkers in a multiple-talker sound field and selectively attending to the desired "target" talker while ignoring the speech from unwanted "masker" talkers and other sources of sound. This listening situation forms the classic "cocktail party problem" described by Cherry (1953) that has received a great deal of study over the past few decades. In this article, a new approach to improving sound source segregation and enhancing auditory selective attention is described...
October 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29049601/age-related-changes-in-objective-and-subjective-speech-perception-in-complex-listening-environments
#10
Karen S Helfer, Gabrielle R Merchant, Peter A Wasiuk
Purpose: A frequent complaint by older adults is difficulty communicating in challenging acoustic environments. The purpose of this work was to review and summarize information about how speech perception in complex listening situations changes across the adult age range. Method: This article provides a review of age-related changes in speech understanding in complex listening environments and summarizes results from several studies conducted in our laboratory. Results: Both degree of high frequency hearing loss and cognitive test performance limit individuals' ability to understand speech in difficult listening situations as they age...
October 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29049038/binaural-integration-a-challenge-to-overcome-for-children-with-hearing-loss
#11
Karen A Gordon, Sharon L Cushing, Vijayalakshmi Easwar, Melissa J Polonenko, Blake C Papsin
PURPOSE OF REVIEW: Access to bilateral hearing can be provided to children with hearing loss by fitting appropriate hearing devices to each affected ear. It is not clear, however, that bilateral input is properly integrated through hearing devices to promote binaural hearing. In the present review, we examine evidence indicating that abnormal binaural hearing continues to be a challenge for children with hearing loss despite early access to bilateral input. RECENT FINDINGS: Behavioral responses and electrophysiological data in children, combined with data from developing animal models, reveal that deafness in early life disrupts binaural hearing and that present hearing devices are unable to reverse these changes and/or promote expected development...
October 18, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29049002/cost-effectiveness-of-the-haemophilus-influenzae-type-b-vaccine-for-infants-in-mainland-china
#12
Guijun Ning, Zundong Yin, Yixing Li, Huaqing Wang, Weizhong Yang
OBJECTIVE: The aims of this study were to estimate the cost-effectiveness of the Haemophilus influenzae type b (Hib) vaccine for the prevention of childhood pneumonia, meningitis and other vaccine-preventable diseases in mainland China from a societal perspective and to provide information about the addition of the Hib vaccine to Chinese immunization programs. METHODS: A decision tree and the Markov model were used to estimate the costs and effectiveness of the Hib vaccine versus no Hib vaccine for a birth cohort of 100,000 children in 2016...
October 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29048736/novel-recessive-pdzd7-biallelic-mutations-in-two-chinese-families-with-non-syndromic-hearing-loss
#13
Jing Guan, Hongyang Wang, Lan Lan, Li Wang, Ju Yang, Linyi Xie, Zifang Yin, Wenping Xiong, Lidong Zhao, Dayong Wang, Qiuju Wang
Autosomal recessive non-syndromic hearing loss (ARNSHL) is a highly heterogeneous genetic condition. PDZD7 has emerged as a new genetic etiology of ARNSHL. Biallelic mutations in the PDZD7 gene have been reported in two German families, four Iranian families, and a Pakistani family with ARNSHL. The effect of PDZD7 on ARNSHL in other population has yet to be elucidated. Two Chinese ARNSHL families, each of which had two affected siblings, were included in this study. The families underwent target region capture and high-throughput sequencing to analyze the exonic, splice-site, and intronic sequences of 128 genes...
October 19, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29048421/recurrent-variants-in-otof-are-significant-contributors-to-prelingual-nonsydromic-hearing-loss-in-saudi-patients
#14
Naif A M Almontashiri, Abdulrahman Alswaid, Andrea Oza, Khalid A Al-Mazrou, Omnia Elrehim, Ahmad Abou Tayoun, Heidi L Rehm, Sami S Amr
PurposeHearing loss is more prevalent in the Saudi Arabian population than in other populations; however, the full range of genetic etiologies in this population is unknown. We report the genetic findings from 33 Saudi hearing-loss probands of tribal ancestry, with predominantly prelingual severe to profound hearing loss.MethodsTesting was performed over the course of 2012-2016, and involved initial GJB2 sequence and GJB6-D13S1830 deletion screening, with negative cases being reflexed to a next-generation sequencing panel with 70, 71, or 87 hearing-loss genes...
October 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29048255/quality-of-life-in-patients-with-unilateral-vestibular-schwannoma-on-wait-and-see-strategy
#15
P C Klersy, F Arlt, M Hofer, J Meixensberger
OBJECTIVE: A 'wait and see' strategy is an option when managing patients with small vestibular schwannomas (VS). A risk of growth and worsening of hearing may influence a patient's daily quality of life (QOL). Therefore, the present study focused on QOL parameters in patients who are on a 'wait and see' strategy following magnetic resonance imaging (MRI)-based diagnosis of small unilateral VS. PATIENTS AND METHODS: Sixty-five patients (mean age 64.4 years; male:female, 32:33) who suffered from a small unilateral VS (9...
October 19, 2017: Neurological Research
https://www.readbyqxmd.com/read/29047013/behavioral-animal-model-of-the-emotional-response-to-tinnitus-and-hearing-loss
#16
Amanda M Lauer, Gail Larkin, Aikeen Jones, Bradford J May
Increased prevalence of emotional distress is associated with tinnitus and hearing loss. The underlying mechanisms of the negative emotional response to tinnitus and hearing loss remain poorly understood, and it is challenging to disentangle the emotional consequences of hearing loss from those specific to tinnitus in listeners experiencing both. We addressed these questions in laboratory rats using three common rodent anxiety screening assays: elevated plus maze, open field test, and social interaction test...
October 18, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29046692/a-patient-with-van-maldergem-syndrome-with-endocrine-abnormalities-hypogonadotropic-hypogonadism-and-breast-aplasia-hypoplasia
#17
Juan Sotos, Katherine Miller, Donald Corsmeier, Naomi Tokar, Benjamin Kelly, Vijay Nadella, Huachun Zhong, Amy Wetzel, Brent Adler, Chack-Yung Yu, Peter White
BACKGROUND: We report a female patient with endocrine abnormalities, hypogonadotropic hypogonadism and amazia (breasts aplasia/hypoplasia but normal nipples and areolas) in a rare syndrome: Van Maldergem syndrome (VMS). CASE PRESENTATION: Our patient was first evaluated at age 4 for intellectual disability, craniofacial features, and auditory malformations. At age 15, she presented with no breast development and other findings consistent with hypogonadotropic hypogonadism...
2017: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/29046308/progress-toward-development-of-a-vaccine-against-congenital-cytomegalovirus-infection
#18
Mark R Schleiss, Sallie R Permar, Stanley A Plotkin
A vaccine against congenital human cytomegalovirus (CMV) infection is a major public health priority. Congenital CMV causes substantial long-term morbidity in newborns, particularly sensorineural hearing loss (SNHL), and the public health impact of this infection on maternal and child health is under-recognized. Although progress toward development of a vaccine has been limited by an incomplete understanding of the correlates of protective immunity for the fetus, knowledge about some of the key components of the maternal immune response necessary for preventing trans-placental transmission is accumulating...
October 18, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/29046124/the-full-blown-mri-of-sudden-hearing-loss-3d-flair-in-a-patient-with-bilateral-metastases-in-the-internal-auditory-canals
#19
Giorgio Conte, Federica Di Berardino, Diego Zanetti, Sabrina Avignone, Clara Sina, Elisabetta Iofrida, Fabio Triulzi
We report a case of a 57-year-old man with bilateral masses in the internal auditory canal. The peculiar findings at magnetic resonance imaging with tridimensional fluid-attenuated inversion recovery sequence combined with clinical data provided new insights into understanding the pathophysiology of the hearing loss.
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29045192/a-dna-vaccine-delivered-by-dermal-electroporation-fully-protects-cynomolgus-macaques-against-lassa-fever
#20
Kathleen A Cashman, Eric R Wilkinson, Carl I Shaia, Paul R Facemire, Todd M Bell, Jeremy J Bearss, Joshua D Shamblin, Suzanne E Wollen, Kate E Broderick, Niranjan Y Sardesai, Connie S Schmaljohn
Lassa virus (LASV) is an ambisense RNA virus in the Arenaviridae family and is the etiological agent of Lassa fever, a severe hemorrhagic disease endemic to West and Central Africa (1,2) . There are no U.S. Food and Drug Administration (FDA)-licensed vaccines available to prevent Lassa fever (1,2) . in our previous studies, we developed a gene-optimized DNA vaccine that encodes the glycoprotein precursor gene of LASV (Josiah strain) and demonstrated that three vaccinations accompanied by dermal electroporation protected guinea pigs from LASV-associated illness and death...
October 18, 2017: Human Vaccines & Immunotherapeutics
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