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https://www.readbyqxmd.com/read/29474382/the-turkish-neonatal-jaundice-online-registry-a-national-root-cause-analysis
#1
Omer Erdeve, Emel Okulu, Ozgur Olukman, Dilek Ulubas, Gokhan Buyukkale, Fatma Narter, Gaffari Tunc, Begum Atasay, Nazli Dilay Gultekin, Saadet Arsan, Esin Koc
BACKGROUND: Neonatal jaundice (NNJ) is common, but few root cause analyses based on national quality registries have been performed. An online registry was established to estimate the incidence of NNJ in Turkey and to facilitate a root cause analysis of NNJ and its complications. METHODS: A multicenter prospective study was conducted on otherwise healthy newborns born at ≥35 weeks of gestation and hospitalized for only NNJ in 50 collaborator neonatal intensive care units across Turkey over a 1-year period...
2018: PloS One
https://www.readbyqxmd.com/read/29472945/an-update-on-phosphodiesterase-mutations-underlying-genetic-etiology-of-hearing-loss-and-retinitis-pigmentosa
#2
Rahul Mittal, Nicole Bencie, James M Parrish, George Liu, Jeenu Mittal, Denise Yan, Xue Zhong Liu
No abstract text is available yet for this article.
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29472286/a-novel-de-novo-capn5-mutation-in-a-patient-with-inflammatory-vitreoretinopathy-hearing-loss-and-developmental-delay
#3
Gabriel Velez, Alexander G Bassuk, Kellie A Schaefer, Brian Brooks, Lokesh Gakhar, MaryAnn Mahajan, Philip Kahn, Stephen H Tsang, Polly J Ferguson, Vinit B Mahajan
Mutations that activate the protease calpain-5 (CAPN5) cause a non-syndromic adult-onset autoinflammatory eye disease characterized by uveitis, altered synaptic signaling, retinal degeneration, neovascularization, and intraocular fibrosis. We describe a pediatric patient with severe inflammatory vitreoretinopathy accompanied by hearing loss and developmental delay associated with a novel, de novo CAPN5 missense mutation (c.865C>T, p.Arg289Trp) that shows greater hyperactivation of the calpain protease, indicating a genotype-phenotype correlation that links mutation severity to proteolytic activity and the possibility of earlier onset syndromic disease with auditory and neurological abnormalities...
February 22, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29472244/age-and-other-factors-affecting-the-outcome-of-aabr-screening-in-neonates
#4
Lise Carolyn Johnson, Margaret Toro, Emily Vishnja, Arielle Berish, Bianca Mills, Zhigang Lu, Ellice Lieberman
BACKGROUND: Although the utility of universal newborn hearing screening is undisputed, testing protocols vary. In particular, the impact of the infant's age at the time of automated auditory brainstem response (AABR) screening has not been well studied. METHODS: We conducted a retrospective review of newborn hearing screening data in 6817 low-risk, term and late-preterm newborns at our large, urban, academic medical center for a 1-year period to analyze the impact of age and other factors on the screening failure rate and referral for diagnostic testing...
February 22, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29472067/neurophysiology-of-hearing-in-patients-with-mucopolysaccharidosis-type-iv
#5
Kyoko Nagao, Thierry Morlet, Elizabeth Haley, Jennifer Padilla, Julianne Nemith, Robert W Mason, Shunji Tomatsu
BACKGROUND: Hearing impairment is a common problem in patients with mucopolysaccharidosis IV (MPS IV) throughout their life. Many of the adult patients with MPS IV exhibit permanent or severe hearing loss. However, there has been no systematic review of detailed audiological test results in MPS IV. MATERIALS AND METHODS: Fourteen individuals with MPS IV (13 MPS IVA and 1 MPS IVB; aged between 12 and 38 years old) participated in the current study. We obtained auditory neurophysiological responses (auditory brainstem responses and otoacoustic emissions test) in addition to pure-tone audiometry and middle ear function tests (tympanometry and acoustic reflexes)...
February 8, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29472062/computational-modeling-of-the-human-auditory-periphery-auditory-nerve-responses-evoked-potentials-and-hearing-loss
#6
REVIEW
Sarah Verhulst, Alessandro Altoè, Viacheslav Vasilkov
Models of the human auditory periphery range from very basic functional descriptions of auditory filtering to detailed computational models of cochlear mechanics, inner-hair cell (IHC), auditory-nerve (AN) and brainstem signal processing. It is challenging to include detailed physiological descriptions of cellular components into human auditory models because single-cell data stems from invasive animal recordings while human reference data only exists in the form of population responses (e.g., otoacoustic emissions, auditory evoked potentials)...
December 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/29471612/analysis-of-output-levels-of-an-mp3-player-effects-of-earphone-type-music-genre-and-listening-duration
#7
Hyunyong Shim, Seungwan Lee, Miseung Koo, Jinsook Kim
Background and Objectives: To prevent noise induced hearing losses caused by listening to music with personal listening devices for young adults, this study was aimed to measure output levels of an MP3 and to identify preferred listening levels (PLLs) depending on earphone types, music genres, and listening durations. Subjects and Methods: Twenty-two normal hearing young adults (mean=18.82, standard deviation=0.57) participated. Each participant was asked to select his or her most PLLs when listened to Korean ballade or dance music with an earbud or an over-the-ear earphone for 30 or 60 minutes...
February 26, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29471611/update-on-bone-conduction-auditory-brainstem-responses-a-review
#8
Young Joon Seo, Chanbeom Kwak, Saea Kim, Yoon Ah Park, Kyoung Ho Park, Woojae Han
Auditory brainstem responses (ABR) have been used as a powerful and the most common objective tool to evaluate hearing sensitivity and to diagnose the types of hearing loss and neurological disorders, through the auditory peripheral pathway to a central level of the brainstem, since 1971. Although bone-conduction (BC) ABR could be an alternative to air-conduction (AC) ABR, as the former overcomes some limitations of the latter, the majority of clinicians rarely utilize it due to a lack of knowledge and no routine test administration...
February 26, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29471610/ototoxicity-a-challenge-in-diagnosis-and-treatment
#9
Purushothaman Ganesan, Jason Schmiedge, Vinaya Manchaiah, Simham Swapna, Subhashini Dhandayutham, Purushothaman Pavanjur Kothandaraman
Ototoxicity is the pharmacological adverse reaction affecting the inner ear or auditory nerve, characterized by cochlear or vestibular dysfunction. The panorama of drug-induced hearing loss has widened over last few decades. Although ototoxic medications play an imperative role in modern medicine, they have the capacity to cause harm and lead to significant morbidity. Evidence has shown early detection of toxicity through prospective ototoxicity monitoring allows for consideration of treatment modifications to minimize or prevent permanent hearing loss and balance impairment...
February 26, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29470486/lassa-fever-induced-sensorineural-hearing-loss-a-neglected-public-health-and-social-burden
#10
REVIEW
Elizabeth J Mateer, Cheng Huang, Nathan Y Shehu, Slobodan Paessler
Although an association between Lassa fever (LF) and sudden-onset sensorineural hearing loss (SNHL) was confirmed clinically in 1990, the prevalence of LF-induced SNHL in endemic countries is still underestimated. LF, a viral hemorrhagic fever disease caused by Lassa virus (LASV), is endemic in West Africa, causing an estimated 500,000 cases and 5,000 deaths per year. Sudden-onset SNHL, one complication of LF, occurs in approximately one-third of survivors and constitutes a neglected public health and social burden...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29470259/pure-tone-audiometry-with-forward-pressure-level-calibration-leads-to-clinically-relevant-improvements-in-test-retest-reliability
#11
Judi A Lapsley Miller, Charlotte M Reed, Sarah R Robinson, Zachary D Perez
OBJECTIVES: Clinical pure-tone audiometry is conducted using stimuli delivered through supra-aural headphones or insert earphones. The stimuli are calibrated in an acoustic (average ear) coupler. Deviations in individual-ear acoustics from the coupler acoustics affect test validity, and variations in probe insertion and headphone placement affect both test validity and test-retest reliability. Using an insert earphone designed for otoacoustic emission testing, which contains a microphone and loudspeaker, an individualized in-the-ear calibration can be calculated from the ear-canal sound pressure measured at the microphone...
February 21, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29469925/how-old-is-too-old-for-cochlear-implantation-for-congenital-bilateral-sensorineural-hearing-loss
#12
Tiffany N Chao, Jessica Levi, Robert C O'Reilly
No abstract text is available yet for this article.
February 22, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29469077/carboplatin-based-concurrent-chemoradiation-therapy-in-locally-advanced-head-and-neck-cancer-patients-who-are-unfit-for-cisplatin-therapy
#13
V Noronha, V Sharma, A Joshi, V M Patil, S G Laskar, K Prabhash
BACKGROUND: Cisplatin-based chemoradiation (CTRT) is the standard of care in locally advanced head and neck cancers. Limited treatment options are available in patients unfit for cisplatin. AIMS: This audit was carried out to study the toxicities, tolerance, and outcomes of carboplatin-based CTRT in patients who are not eligible for cisplatin. MATERIALS AND METHODS: A total of 63 locally advanced head and neck cancer patients treated between January 2011 and October 2015 were administered carboplatin-based CTRT...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29468919/health-related-quality-of-life-in-hearing-impaired-adolescents-and-children
#14
Riina Niemensivu, Risto Paavo Roine, Harri Sintonen, Erna Kentala
OBJECTIVE: To evaluate health-related quality of life (HRQoL) in hearing-impaired adolescents and children and to compare it with that of hearing individuals. STUDY DESIGN AND SETTING: Hearing-impaired adolescents and children were recruited to the study during their annual control visit to the Hearing Clinic of Helsinki University Hospital. They filled in a HRQoL questionnaire, either the 16-dimensional 16D (adolescents aged 12-17 years) or the 17-dimensional 17D (children aged 7-11 years)...
February 22, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29468101/idiopathic-sudden-sensorineural-hearing-loss-average-time-elapsed-before-presentation-to-the-otolaryngologist-and-effectiveness-of-oral-and-or-intratympanic-steroids-in-late-presentations
#15
Anwuli Anyah, Devin Mistry, Erin Kevern, Kenneth Markiewicz
Objectives To determine how long after symptom onset that the average patient with an idiopathic sudden sensorineural hearing loss (ISSNHL) presents to the otolaryngology clinic.  In late presentations, to determine the time to presentation cutoff after which intervention may not be effective.  To evaluate the effectiveness of oral steroids versus a combination of oral and intratympanic steroid therapy in late presentations of ISSNHL.  Methods and procedures Sixty-four patients met inclusion criteria after chart review of 2,037 patients seen at Metro Health Hospital from 2006 to 2016 for sensorineural hearing loss...
December 14, 2017: Curēus
https://www.readbyqxmd.com/read/29466997/hearing-impairment-in-melas-new-prospective-in-clinical-use-of-microrna-a-systematic-review
#16
REVIEW
Arianna Di Stadio, Valentina Pegoraro, Laura Giaretta, Laura Dipietro, Roberta Marozzo, Corrado Angelini
AIM: To evaluate the feasibility of microRNAs (miR) in clinical use to fill in the gap of current methodology commonly used to test hearing impairment in MELAS patients. MATERIAL AND METHOD: A literature review was performed using the following keywords, i.e., MELAS, Hearing Loss, Hearing Impairment, Temporal Bone, Otoacustic Emission (OTOAE), Auditory Brain Response (ABR), and microRNA. We reviewed the literature and focused on the aspect of the temporal bone, the results of electrophysiological tests in human clinical studies, and the use of miR for detecting lesions in the cochlea in patients with MELAS...
February 21, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29466495/monitoring-auditory-cortical-plasticity-in-hearing-aid-users-with-long-latency-auditory-evoked-potentials-a-longitudinal-study
#17
Renata Aparecida Leite, Fernanda Cristina Leite Magliaro, Jeziela Cristina Raimundo, Ricardo Ferreira Bento, Carla Gentile Matas
OBJECTIVE: The objective of this study was to compare long-latency auditory evoked potentials before and after hearing aid fittings in children with sensorineural hearing loss compared with age-matched children with normal hearing. METHODS: Thirty-two subjects of both genders aged 7 to 12 years participated in this study and were divided into two groups as follows: 14 children with normal hearing were assigned to the control group (mean age 9 years and 8 months), and 18 children with mild to moderate symmetrical bilateral sensorineural hearing loss were assigned to the study group (mean age 9 years and 2 months)...
February 19, 2018: Clinics
https://www.readbyqxmd.com/read/29466265/characteristics-of-real-world-signal-to-noise-ratios-and-speech-listening-situations-of-older-adults-with-mild-to-moderate-hearing-loss
#18
Yu-Hsiang Wu, Elizabeth Stangl, Octav Chipara, Syed Shabih Hasan, Anne Welhaven, Jacob Oleson
OBJECTIVES: The first objective was to determine the relationship between speech level, noise level, and signal to noise ratio (SNR), as well as the distribution of SNR, in real-world situations wherein older adults with hearing loss are listening to speech. The second objective was to develop a set of prototype listening situations (PLSs) that describe the speech level, noise level, SNR, availability of visual cues, and locations of speech and noise sources of typical speech listening situations experienced by these individuals...
March 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29465841/permanent-childhood-hearing-impairment-aetiological-evaluation-of-infants-identified-through-the-irish-newborn-hearing-screening-programme
#19
A Smith, A O'Connor, S Hennessy, P G O'Sullivan, L Gibson
The Newborn Hearing Screening Programme (NHSP) was established in Cork University Maternity Hospital (CUMH) in April 2011. Between April 2011 and July 2014, 42 infants were identified with a Permanent Childhood Hearing Impairment (PCHI). Following this diagnosis, infants underwent a paediatric assessment according to recognised guidelines with the intention of identifying the underlying aetiology of the PCHI. The aim of this study was to assess the findings of this aetiological workup via retrospective chart review...
December 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29464271/-noise-induced-neurodegeneration-in-the-central-auditory-pathway-an-overview-of-experimental-studies-in-a-mouse-model
#20
REVIEW
M Gröschel, A Ernst, D Basta
BACKGROUND: A noise trauma induces central nervous system pathologies, which generate deficits in hearing and perception of sound. OBJECTIVE: Are degenerative mechanisms in the central auditory system a direct impact of overstimulation or an effect of acoustic deprivation? MATERIALS AND METHODS: Detection of cell death in a mouse model of noise-induced hearing loss at different times after single or repeated noise exposure. RESULTS: A single noise exposure (3 h, 115 dB SPL, 5-20 kHz) induces acute (≤1 day) and long-term (observation period 14 days) degeneration, particularly in subcortical structures...
February 20, 2018: HNO
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