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https://www.readbyqxmd.com/read/29666347/marker-assisted-introgression-of-opaque2-allele-for-rapid-conversion-of-elite-hybrids-into-quality-protein-maize
#1
Firoz Hossain, Vignesh Muthusamy, Neha Pandey, Ashish K Vishwakarma, Aanchal Baveja, Rajkumar U Zunjare, Nepolean Thirunavukkarasu, Supradip Saha, Kanchikeri M Manjaiah Manjaiah, Boddupalli M Prasanna, Hari S Gupta
Maize is a valuable source of food and feed worldwide. Maize endosperm protein is, however nutritionally poor due to the reduced levels of two essential amino acids, lysine and tryptophan. In this study, recessive opaque2 (o2) allele that confers enhanced endosperm lysine and tryptophan, was introgressed using marker-assisted backcross breeding into three normal inbred lines (HKI323, HKI1105 and HKI1128). These are the parental lines of three popular medium-maturing single cross hybrids (HM4, HM8 and HM9) in India...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29664985/photodynamic-therapy-induced-macular-hole
#2
Margaret A Greven, Loh-Shan B Leung
A 72-year-old female with neovascular macular degeneration refractory to anti-vascular endothelial growth factor injections underwent photodynamic therapy and subsequently developed a macular hole (MH) associated with vitreomacular traction. After a period of observation, the MH enlarged. Pars plana vitrectomy was performed, and the MH was closed successfully. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:270-272.].
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29664094/analysis-of-poly-adp-ribose-polymerase-1-by-enzyme-initiated-auto-parylation-controlled-aggregation-of-hemin-graphene-nanocomposites
#3
Yong Liu, Xiaolin Xu, Haitang Yang, Ensheng Xu, Shuangshuang Wu, Wei Wei, Jin Chen
Poly(ADP-ribose) polymerase-1 (PARP-1) is a highly conserved nuclear enzyme, which binds tightly to damaged DNA and plays a key role in DNA repair, recombination, proliferation, and genomic stability. However, due to the poor electrochemical and optical activity of PARP-1 and its product PAR, only a few studies on its activity detection method have been reported. Herein, we report a simple and sensitive colorimetric strategy to monitor PARP-1 activity based on enzyme-initiated auto-PARylation-controlled aggregation of hemin-graphene nanocomposites (H-GNs)...
April 17, 2018: Analyst
https://www.readbyqxmd.com/read/29663190/time-dependent-upregulation-of-electron-transport-with-concomitant-induction-of-regulated-excitation-dissipation-in-haslea-diatoms
#4
R Perkins, C Williamson, J Lavaud, J-L Mouget, D A Campbell
Photoacclimation by strains of Haslea "blue" diatom species H. ostrearia and H. silbo sp. nov. ined. was investigated with rapid light curves and induction-recovery curves using fast repetition rate fluorescence. Cultures were grown to exponential phase under 50 µmol m-2  s-1 photosynthetic available radiation (PAR) and then exposed to non-sequential rapid light curves where, once electron transport rate (ETR) had reached saturation, light intensity was decreased and then further increased prior to returning to near growth light intensity...
April 16, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29662750/return-to-play-in-adolescent-athletes-with-symptomatic-spondylolysis-without-listhesis-a-meta-analysis
#5
REVIEW
Samuel C Overley, Steven J McAnany, Steve Andelman, Jun Kim, Robert K Merrill, Samuel K Cho, Sheeraz A Qureshi, Andrew C Hecht
Study Design: Meta-analysis. Objectives: To assess return to play (RTP) rates in adolescent athletes with lumbar spondylolysis without spondylolisthesis treated conservatively or operatively. Methods: A review of Medline, EMBASE, and Cochrane Reviews was performed. The pooled results were performed by calculating the effect size based on the logit event rate. Studies were weighted by the inverse of the variance. Confidence intervals were reported at 95%...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29662741/predictive-factors-for-the-outcome-of-surgical-treatment-of-lumbar-spondylolysis-in-young-sporting-individuals
#6
Ujjwal K Debnath, B E Scammell, Brian J C Freeman, Jeffrey R McConnell
Study Design: Retrospective consecutive case series. Objectives: Only few sporting individuals with symptomatic lumbar pars injuries require surgical repair and it is often difficult to predict the outcome following surgery. The factors that predict the outcome after direct repair of lumbar pars defect was evaluated clinically and statistically. The preoperative background variables both subjective and objective as well as radiological evaluation were used in a multiple regression model to find the strong predictors of postoperative outcome as measured by VAS (visual analogue scores), ODI (Oswestry Disability Index) and SF-36 (Short Form)...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29660308/the-effects-of-replacing-eggs-with-chicks-on-mesotocin-dopamine-and-prolactin-in-the-native-thai-hen
#7
Panpradap Sinpru, Natagarn Sartsoongnoen, Israel Rozenboim, Tom E Porter, Mohamed E El Halawani, Yupaporn Chaiseha
The mesotocinergic (MTergic) and dopaminergic (DAergic) systems have been documented to play pivotal roles in maternal behaviors in native Thai chickens. In native Thai chickens, plasma prolactin (PRL) concentrations are associated with maternal behaviors, which are also controlled by the DAergic system. However, the role of MT in conjunction with the roles of DA and PRL on the neuroendocrine regulation of the transition from incubating to rearing behavior has never been studied. Therefore, the aim of this study was to investigate the association of MT, DA, and PRL during the transition from incubating to rearing behavior in native Thai hens...
April 13, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29658436/thrombin-alters-human-endometrial-stromal-cell-differentiation-during-decidualization
#8
Samir N Babayev, Mohammed Kanchwala, Chao Xing, Yucel Akgul, Bruce R Carr, Ruth Ann Word
Vaginal bleeding and subchorionic hematomas are associated with increased risk of both early and late pregnancy loss. Thrombin generation may play a pivotal role in the development of these complications. To determine the effects of thrombin on human endometrial stromal cells (hESCs), cells were treated with thrombin at baseline or during decidualization with cyclic adenosine monophosphate (cAMP)+medroxyprogesterone acetate (MPA). Next-generation RNA sequencing revealed that markers of decidualization (IGF-1, IGFBP-1, and prolactin [PRL]) were induced after the initiation of decidualization, whereas thrombin suppressed insulin-like growth factor ( IGF)-1, Insulin-like growth factor binding protein ( IGFBP)-1, and PRL gene expression at baseline and during decidualization...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29657058/incremental-prognostic-value-of-coronary-and-systemic-atherosclerosis-after-myocardial-infarction
#9
Fredrik Calais, Maja Eriksson Östman, Pär Hedberg, Andreas Rosenblad, Jerzy Leppert, Ole Fröbert
BACKGROUND: The role of systemic atherosclerosis in myocardial infarction (MI) patients is not fully understood. We investigated the incremental prognostic value of coronary and systemic atherosclerosis after acute MI by estimating extra-cardiac artery disease (ECAD) and extent of coronary atherosclerosis. METHODS AND RESULTS: The study included 544 prospective MI patients undergoing coronary angiography. For all patients, the longitudinal coronary atherosclerotic extent, expressed as Sullivan extent score (SES) was calculated...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29656174/multiplanar-realignment-for-unstable-hangman-s-fracture-with-posterior-c2-3-fusion-a-prospective-series
#10
Pravin Salunke, Madhivanan Karthigeyan, Sushanta K Sahoo, Prashant K Prasad
OBJECTIVE: There is lack of consensus on the preferred approach for unstable Hangman's fracture. The associated soft tissue injuries apart from apparent bony injury add to the complexity of dislocation and needs to be addressed. Here, we evaluated the clinico-radiological characteristics and outcome of patients managed by posterior C2-3 fusion. PATIENTS & METHODS: Nine patients with unstable Hangman's fracture (type II and IIA) were prospectively studied. The displacement of fractured fragments and C2-3 dislocation was studied in multiple planes...
March 27, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29656043/pituitary-estrogen-receptor-alpha-is-involved-in-luteinizing-hormone-pulsatility-at-mid-gestation-in-the-south-american-plains-vizcacha-lagostomus-maximus-rodentia-caviomorpha
#11
Sofía Proietto, Lorena Yankelevich, Federico Martín Villarreal, Pablo Ignacio Felipe Inserra, Santiago Elías Charif, Alejandro Raúl Schmidt, Santiago Andrés Cortasa, María Clara Corso, Noelia Paula Di Giorgio, Victoria Lux-Lantos, Alfredo Daniel Vitullo, Julia Halperin, Verónica Berta Dorfman
The South American plains vizcacha, Lagostomus maximus, is a caviomorph rodent native from Argentina, Bolivia and Paraguay. It shows peculiar reproductive features like pre-ovulatory follicle recruitment during pregnancy with an ovulatory process at around mid-gestation. We have described the activation of the hypothalamic - pituitary - ovarian (HPO) axis during pregnancy. A progressive decrease of progesterone (P4) at mid-pregnancy elicits the delivery of gonadotropin-releasing hormone (GnRH) with the consequent secretion of follicle stimulating hormone (FSH) and estradiol (E2 ) followed by luteinizing hormone (LH) release resulting in follicular luteinization and the P4 concentration recover...
April 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29656006/par-4-dependent-p53-up-regulation-plays-a-critical-role-in-thymoquinone-induced-cellular-senescence-in-human-malignant-glioma-cells
#12
Karthikeyan Subburayan, Faisal Thayyullathil, Siraj Pallichankandy, Anees Rahman, Sehamuddin Galadari
Thymoquinone (TQ), the predominant bioactive constituent present in black cumin (Nigella sativa), exerts tumor suppressive activity against a wide variety of cancer cells. Cellular senescence, characterized by stable and long term loss of proliferative capacity, acts as a potent tumor suppressive mechanism. Here, we provide evidence for the first time that TQ suppresses growth of glioma cells by potentially inducing the expression of prostate apoptosis response-4 (Par-4) tumor suppressor protein. In turn, TQ-induced Par-4 expression triggers cellular senescence, as evidenced by increasing cellular size, β-galactosidase staining, G1 phase arrest, and increased expression of senescence markers such as p53, p21, Rb, and decreased expression of lamin B1, cyclin E and cyclin depended kinase-2 (CDK-2)...
April 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29655942/pink1-p-k520rfsx3-mutation-identified-in-a-chinese-family-with-early-onset-parkinson-s-disease
#13
Peng Wang, Yi Guo, Chengyuan Song, Yiming Liu, Hao Deng
Parkinson's disease (PD) features selective loss of dopaminergic neurons of the substantia nigra pars compacta accompanied by the accumulation and aggregation of alpha-synuclein in Lewy bodies. PTEN induced putative kinase 1 gene (PINK1) mutations are the second most common genetic cause of autosomal recessive early-onset Parkinson's disease (EOPD). A single nucleotide deletion in PINK1 exon 8 (c.1557delG) was identified in a consanguineous Chinese family with EOPD. The homozygous deletion was co-segregated with disease in the family and resulted in a frameshift after codon 520 with a premature termination at codon 522 (p...
April 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29653250/pluripotent-stem-cell-based-therapy-for-parkinson-s-disease-current-status-and-future-prospects
#14
REVIEW
Kai-C Sonntag, Bin Song, Nayeon Lee, Jin Hyuk Jung, Young Cha, Pierre Leblanc, Carolyn Neff, Sek Won Kong, Bob S Carter, Jeffrey Schweitzer, Kwang-Soo Kim
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which affects about 0.3% of the general population. As the population in the developed world ages, this creates an escalating burden on society both in economic terms and in quality of life for these patients and for the families that support them. Although currently available pharmacological or surgical treatments may significantly improve the quality of life of many patients with PD, these are symptomatic treatments that do not slow or stop the progressive course of the disease...
April 10, 2018: Progress in Neurobiology
https://www.readbyqxmd.com/read/29652690/endophthalmitis-after-pars-plana-vitrectomy-efficacy-of-intraoperative-subconjunctival-antibiotics
#15
Stephanie J Weiss, Murtaza K Adam, Xinxiao Gao, Anthony Obeid, Arunan Sivalingam, Mitchell S Fineman, Joseph I Maguire, Sunir J Garg, Julia Haller, David H Fischer, Jason Hsu
PURPOSE: To examine rates of acute infectious endophthalmitis after pars plana vitrectomy (PPV) in eyes that received intraoperative subconjunctival antibiotics versus eyes that did not. METHODS: A retrospective, nonrandomized, comparative case series of 18,886 consecutive cases of transconjunctival 23-, 25-, and 27-gauge PPV over a 5-year period was performed. The impact of prophylactic intraoperative subconjunctival antibiotics on the development of acute infectious postoperative endophthalmitis was examined...
April 12, 2018: Retina
https://www.readbyqxmd.com/read/29652556/concordance-of-non-low-risk-disease-among-pairs-of-brothers-with-prostate-cancer
#16
Fredrik Jansson, Linda Drevin, Thomas Frisell, Pär Stattin, Ola Bratt, Olof Akre
Purpose Prostate cancer among first-degree relatives is a strong risk factor for diagnosis of prostate cancer, and the contribution of heritable factors in prostate cancer etiology is high. We investigated how the concordance of non-low-risk prostate cancer among brothers is affected by their genetic relation. Methods We identified 4,262 pairs of brothers with prostate cancer in the Prostate Cancer Database Sweden. Their cancers were categorized as low risk (Gleason score ≤ 6; clinical stage T1-2, Nx/N0, Mx/M0; and prostate-specific antigen ≤ 10 ng/mL) or non-low risk...
April 13, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29651238/par-complex-and-crumbs-function-during-photoreceptor-morphogenesis-and-retinal-degeneration
#17
REVIEW
Franck Pichaud
The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29650054/global-commitments-and-china-s-endeavors-to-promote-health-and-achieve-sustainable-development-goals
#18
REVIEW
Xiaodong Tan, Qian Wu, Haiyan Shao
BACKGROUND: With its immense population and as the largest developing country in the world, China has made remarkable achievements in health promotion at a relatively low cost. However, China is still faced with challenges such as changes of disease spectrum, the coming era of an aging society, and the risk of environmental pollution. MAIN TEXT: On October 25, 2016, China formally passed the blueprint of "Healthy China 2030," working towards the national goal of reaching a health standard on par with developed countries by 2030, which was also a response to realize the 2030 United Nations Sustainable Development Goals...
April 12, 2018: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29649485/occult-globe-rupture-diagnostic-and-treatment-challenge
#19
REVIEW
Argyrios Chronopoulos, Jong Min Ong, Gabriele Thumann, James S Schutz
Occult globe rupture is a traumatic dehiscence of the sclera at or posterior to the rectus muscle insertions without a visible eye wall defect on slit lamp examination. Occult scleral ruptures are important because they can be difficult to diagnose, but normally require preoperative protection against external pressure to reduce risk of herniation of ocular contents through the rupture and then urgent surgical repair to restore eye wall structural integrity and achieve optimum prognosis. A deeper than normal anterior chamber with posteriorly retracted plateau iris seen immediately after acute ocular trauma is virtually pathognomonic of posterior globe dehiscence...
April 9, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29649268/a-case-control-study-of-lower-urinary-tract-infections-associated-antibiotics-and-the-risk-of-developing-prostate-cancer-using-pcbase-3-0
#20
Beth Russell, Hans Garmo, Kerri Beckmann, Pär Stattin, Jan Adolfsson, Mieke Van Hemelrijck
OBJECTIVES: To investigate the association between lower urinary-tract infections, their associated antibiotics and the subsequent risk of developing PCa. SUBJECTS/PATIENTS (OR MATERIALS) AND METHODS: Using data from the Swedish PCBaSe 3.0, we performed a matched case-control study (8762 cases and 43806 controls). Conditional logistic regression analysis was used to assess the association between lower urinary-tract infections, related antibiotics and PCa, whilst adjusting for civil status, education, Charlson Comorbidity Index and time between lower urinary-tract infection and PCa diagnosis...
2018: PloS One
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