Hee Byung Koh, Hyung Woo Kim, Chan-Young Jung, Yaeji Lee, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Joongyub Lee, Yeong Hoon Kim, Dong-Wan Chae, Woo Kyung Chung, Kook-Hwan Oh, Seung Hyeok Han
BACKGROUND: Many trials have attempted to slow the progression of chronic kidney disease (CKD) by modifying specific risk factors, but without achieving satisfactory results. We aimed to evaluate the association between the degree of improvement in multiple risk factors and adverse kidney outcomes. METHODS: This was a prospective observational study of 839 patients with CKD G3-G4. The main predictors were the number of improved risk factors between baseline and year one as follows: a decrease in proteinuria, systolic blood pressure, phosphate, and uric acid, and an increase in hemoglobin and bicarbonate from the baseline status to out of the target range...
April 2023: Journal of Nephrology