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Uric acid in renal transplants

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https://www.readbyqxmd.com/read/28476205/therapeutic-efficacy-of-human-umbilical-cord-mesenchymal-stem-cells-transplantation-against-renal-ischemia-reperfusion-injury-in-rats
#1
Sohair R Fahmy, Amel M Soliman, Mervat El Ansary, Samah Abd Elhamid, Heba Mohsen
BACKGROUND: Acute kidney injury (AKI) is a common clinical problem raising the urgent needs to develop new strategies for treatment. The present study investigated the therapeutic potential of human umbilical cord - mesenchymal stem cells (HUC-MSCs) transplantation against renal ischemia/reperfusion injury (IRI) in rats. METHODS: Twenty four male Wistar rats were assigned into two main groups, sham group (control group) and I/R group. I/R group was injected in the tail vein with either phosphate buffer saline (PBS) or HUC-MSCs...
June 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28452970/one%C3%A2-year-survival-of-ambulatory-patients-with-end%C3%A2-stage-heart-failure-the-analysis-of-prognostic-factors
#2
Bożena Szygula-Jurkiewicz, Wioletta Szczurek, Michał Skrzypek, Michał Zakliczyński, Łukasz Siedlecki, Piotr Przybyłowski, Marian Zembala, Mariusz Gąsior
INTRODUCTION    An increasing number of ambulatory patients are placed on orthotopic heart transplantation (OHT) waiting lists, which results in an extended waiting time and a higher mortality rate. OBJECTIVES    The aim of this study was to identify the factors associated with reduced survival during a 1‑year follow‑up in patients with end‑stage heart failure listed for an OHT. PATIENTS AND METHODS    We retrospectively analyzed the data of 221 adult patients, who were accepted for OHT in our institution over a 2‑year period between 2013 and 2014...
April 28, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28429125/low-plasma-homoarginine-concentration-is-associated-with-high-rates-of-all-cause-mortality-in-renal-transplant-recipients
#3
Arslan Arinc Kayacelebi, Isidor Minović, Erik Hanff, Anne-Roos S Frenay, Martin H de Borst, Martin Feelisch, Harry van Goor, Stephan J L Bakker, Dimitrios Tsikas
In renal transplant recipients (RTR), we recently found that low urinary excretion of homoarginine (hArg) is associated with mortality and graft failure. However, it is not known whether such prospective associations also hold true for plasma concentrations of hArg. In the present study, we therefore determined plasma concentrations of hArg in the same cohort, i.e. in 687 RTR (functioning graft ≥1 year), and in 140 healthy donors, before and after kidney donation. Plasma hArg concentrations were significantly lower in RTR compared to healthy controls [1...
April 20, 2017: Amino Acids
https://www.readbyqxmd.com/read/28347282/hyperuricemia-after-orthotopic-liver-transplantation-divergent-associations-with-progression-of-renal-disease-incident-end-stage-renal-disease-and-mortality
#4
Joseph C Longenecker, Sana Waheed, Ghassan Bandak, Christine A Murakami, Blaithin A McMahon, Allan C Gelber, Mohamed G Atta
BACKGROUND: Although hyperuricemia is common after orthotopic liver transplantation (OLT), its relationship to mortality, progressive kidney disease, or the development of end stage renal disease (ESRD) is not well-described. METHODS: Data from 304 patients undergoing OLT between 1996 and 2010 were used to assess the association of mean serum uric acid (UA) level in the 3-months post-OLT with mortality, doubling of creatinine, and ESRD incidence. Post-OLT survival to event outcomes according to UA level and eGFR was assessed using the Kaplan Meier method and multivariate Cox proportional hazards models...
March 27, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28340822/risk-factors-of-hyperuricemia-after-renal-transplantation-and-its-long-term-effects-on-graft-functions
#5
S Eyupoglu, D Eyupoglu, Z Kendi-Celebi, S Akturk, A Tuzuner, K Keven, S Sengul
BACKGROUND: Hyperuricemia is a common complication in renal transplant recipients. Recent studies have suggested that hyperuricemia may contribute to the deterioration of graft function. METHODS: In this study, we aimed to investigate the risk factors related to hyperuricemia and the effects of hyperuricemia on graft dysfunction, graft survival, cardiovascular events, and mortality rates. Between the years 2005 and 2016, 141 renal transplantation patients with at least 5 years of follow-up were included in this retrospective cohort study...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28262263/renal-function-is-similar-in-solitary-kidneys-from-patients-with-and-without-diabetes
#6
Cristina Gluhovschi, Gheorghe Gluhovschi, Florica Gadalean, Silvia Velciov, Ligia Petrica, Bogdan Timar, Adriana Kaycsa, Romulus Timar
OBJECTIVES: Due to the shortage of living kidney donors and the current diabetes mellitus (DM) pandemic, studying the association of solitary kidney (SK) with DM is of paramount importance. Our aim was to assess the significance of the association between SK and DM. MATERIALS AND METHODS: Eighty-four patients with SK and DM (group A), with a mean age of 62.46±12.72 years, of whom 36 were males and 48 were females, were enrolled in the study. The control group (group B) comprised 84 SK patients without DM of similar age and duration of existence of a SK...
March 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28104163/hyperuricemia-and-acute-renal-failure-in-renal-transplant-recipients-treated-with-high-dose-mizoribine
#7
K Akioka, T Ishikawa, M Osaka, Y Kadotani, K Okugawa, K Nakano, Y Osaka, K Tsuchiya, H Sako
BACKGROUND: Hyperuricemia is a common adverse event frequently found in renal transplant recipients with mizoribine (MZ). Hyperuricemia itself will be a cause of renal dysfunction, and renal dysfunction also will be a cause of hyperuricemia simultaneously. This study investigates frequency of hyperuricemia and renal failure in renal transplant recipients treated with high-dose MZ. PATIENTS AND METHODS: From December 2007 to October 2015, there was a total of 32 living related renal transplant recipients treated with high-dose MZ...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28101832/serum-uric-acid-levels-contribute-to-new-renal-damage-in-systemic-lupus-erythematosus-patients
#8
C Reátegui-Sokolova, Manuel F Ugarte-Gil, Rocío V Gamboa-Cárdenas, Francisco Zevallos, Jorge M Cucho-Venegas, José L Alfaro-Lozano, Mariela Medina, Zoila Rodriguez-Bellido, Cesar A Pastor-Asurza, Graciela S Alarcón, Risto A Perich-Campos
This study aims to determine whether uric acid levels contribute to new renal damage in systemic lupus erythematosus (SLE) patients. This prospective study was conducted in consecutive patients seen since 2012. Patients had a baseline visit and follow-up visits every 6 months. Patients with ≥2 visits were included; those with end-stage renal disease (regardless of dialysis or transplantation) were excluded. Renal damage was ascertained using the SLICC/ACR damage index (SDI). Univariable and multivariable Cox-regression models were performed to determine the risk of new renal damage...
April 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28031169/the-hypoxanthine-xanthine-oxidase-axis-is-not-involved-in-the-initial-phase-of-clinical-transplantation-related-ischemia-reperfusion-injury
#9
Leonie G M Wijermars, Jaap A Bakker, Dorottya K de Vries, Cornelis J F van Noorden, Jorgen Bierau, Sarantos Kostidis, Oleg A Mayboroda, Dimitrios Tsikas, Alexander F Schaapherder, Jan H N Lindeman
The hypoxanthine-xanthine oxidase (XO) axis is considered to be a key driver of transplantation related ischemia reperfusion (I/R) injury. Whereas interference with this axis effectively quenches I/R injury in preclinical models, there is limited efficacy of XO inhibitors in clinical trials. In this context, we considered clinical evaluation of a role for the hypoxanthine-XO axis in human I/R to be relevant. Patients undergoing renal allograft transplantation were included (n=40) and classified based on duration of ischemia (short; intermediate; prolonged)...
December 28, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27932106/assessment-of-kidney-graft-function-evolution-measured-by-creatinine-and-cystatin-c
#10
M A Ramos-Barron, I Hernandez Bejarano, E Rodrigo, E Cruz Iglesias, A Benito Hernandez, C Agueros Blanco, A I Morales Martin, M Prieto Vicente, F Lopez Hernandez, M Arias, C Gomez-Alamillo
INTRODUCTION: The 2013 Kidney Disease Outcomes Quality Initiative Clinical Practice Guideline suggests measuring cystatin C (sCys) in adults with glomerular filtration rate (GFR) based on creatinine (sCr) between 45 and 59 mL/min/1.73 m(2) if confirmation of chronic kidney disease (CKD) is required. There is not enough evidence to recommend the use of sCys or sCr to estimate GFR in kidney transplant recipients. OBJECTIVES: Our aims were to describe the evolution of sCr, sCys, and GFR in a group of kidney transplant patients and to determine their association with some markers of morbidity at 1 year...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27905009/increased-serum-al-levels-in-hemodialysis-patients-kept-enhanced-during-a-2-year-prospective-study
#11
Maria L Reina de la Torre, Herminia Lopez García de la Serrana, Loreto Martí Del Moral, Magdalena Palomares Bayo, Miguel Navarro-Alarcón
The regulation of mineral homeostasis is altered in hemodialysis patients with renal insufficiency, producing increased risk for secondary diseases like cardiovascular ones. We hypothesized that risen serum aluminum (Al) concentration in hemodialysis patients kept enhanced during a 2-year longitudinal study is associated with enhanced cardiovascular risk and influenced by medical treatments. This study reports the prospective monitoring of serum Al levels in six-monthly samplings over 2 years in 116 hemodialysis patients and a control group of 50 healthy adults...
November 30, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27825577/efficacy-and-safety-of-febuxostat-in-73-gouty-patients-with-stage-4-5-chronic-kidney-disease-a-retrospective-study-of-10-centers
#12
Pierre-Antoine Juge, Marie-Elise Truchetet, Evangeline Pillebout, Sébastien Ottaviani, Cécile Vigneau, Clotilde Loustau, Divi Cornec, Tristan Pascart, Renaud Snanoudj, Florian Bailly, Emilie Cornec-Le Gall, Thierry Schaeverbeke, Alain Saraux, Philippe Dieudé, René-Marc Flipo, Pascal Richette, Frédéric Lioté, Thomas Bardin, Gérard Chalès, Hang-Korng Ea
OBJECTIVES: The allopurinol dose is limited in chronic kidney disease, particularly stage 4/5 chronic kidney disease. Febuxostat has a hepatic metabolism and has been approved without dose adaptation in gouty patients with stage 1-3 chronic kidney disease. We aimed to study the safety and efficacy of febuxostat for stage 4/5 chronic kidney disease. METHODS: In this retrospective study, we included patients with (1) a diagnosis of gout, (2) febuxostat treatment, (3) estimated glomerular filtration rate≤30mL/min/1...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27776720/identifying-different-causes-of-hyponatremia-with-fractional-excretion-of-uric-acid
#13
Louis J Imbriano, Joseph Mattana, James Drakakis, John K Maesaka
BACKGROUND: There is controversy over the prevalence of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral or renal salt wasting (RSW), 2 syndromes with identical common clinical and laboratory parameters but different therapies. The traditional approach to the hyponatremic patient relies on volume assessment, but there are limitations to this method. METHODS: We used an algorithm that relies on fractional excretion of urate (FEurate) to evaluate patients with hyponatremia and present 4 illustrative cases...
October 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27701176/the-protective-effect-of-febuxostat-on-chronic-tacrolimus-induced-nephrotoxicity-in-rats
#14
Hyun Seon Kim, Sun Woo Lim, Long Jin, Jian Jin, Byung Ha Chung, Chul Woo Yang
BACKGROUND: The use of calcineurin inhibitors is a well-known risk factor for hyperuricemia in kidney transplant recipients. We evaluated the effect of febuxostat (Fx), a new uric acid-lowering drug, on hyperuricemia and renal injury in an experimental model of chronic tacrolimus (Tac)-induced nephropathy. METHODS: Chronic Tac nephropathy was induced by administering Tac (1.5 mg/kg/day) to rats on a low-salt diet (0.05%) with oxonic acid (OA, 2%, 0.2 g/kg/day) for 28 days...
2017: Nephron
https://www.readbyqxmd.com/read/27679713/fgf23-is-associated-with-early-post-transplant-hypophosphataemia-and-normalizes-faster-than-ipth-in-living-donor-renal-transplant-recipients-a-longitudinal-follow-up-study
#15
Narayan Prasad, Akhilesh Jaiswal, Vikas Agarwal, Shashi Kumar, Saurabh Chaturvedi, Subhash Yadav, Amit Gupta, Raj K Sharma, Dharmendra Bhadauria, Anupama Kaul
BACKGROUND: We aimed to longitudinally analyse changes in the levels of serum fibroblast growth factor 23 (FGF23), intact parathyroid hormone (iPTH) and associated minerals in patients undergoing renal transplantation. METHODS: Sixty-three patients with end-stage renal disease (ESRD) who underwent living donor transplantation were recruited. Serum FGF23, iPTH, uric acid, inorganic phosphorous (iP), blood urea nitrogen and serum creatinine were measured pre-transplant and at 1 (M1), 3 (M3) and 12 months (M12) post-transplantation...
October 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27500236/renal-function-in-kidney-and-liver-transplant-recipients-after-a-130-km-road-cycling-race
#16
Giovanni Mosconi, Giulio Sergio Roi, Valentina Totti, Marco Zancanaro, Alessandra Tacconi, Paola Todeschini, Eric Ramazzotti, Rocco Di Michele, Manuela Trerotola, Carlo Donati, Alessandro Nanni Costa
BACKGROUND: A few patients, after receiving solid organ transplantation, return to performing various sports and competitions; however, at present, data no study had evaluated the effects of endurance cycling races on their renal function. METHODS: Race times and short form (36) health survey questionnaires of 10 kidney transplant recipients (KTR) and 8 liver transplant recipients (LTR) transplanted recipients involved in a road cycling race (130 km) were compared with 35 healthy control subjects (HCS), also taking laboratory blood and urine tests the day before the race, at the end of the race, and 18 to 24 hours after competing...
October 2015: Transplantation Direct
https://www.readbyqxmd.com/read/27447713/2-8-dihydroxyadenine-nephropathy-identified-as-cause-of-end-stage-renal-disease-after-renal-transplant
#17
Smiley Annie George, Sulaiman Al-Rushaidan, Issam Francis, Darius Soonowala, M R Narayanan Nampoory
Adenine phosphoribosyltransferase deficiency is a rare autosomal recessive disorder of uric acid metabolism that leads to formation and excretion of 2,8-dihydroxyadenine into urine. The low solubility of 2,8-dihydroxyadenine results in precipitation and formation of urinary crystals and renal stones. Patients with this disorder usually have recurrent nephrolithiasis and can develop nephropathy secondary to crystal precipitation in the renal parenchyma. The disease is most often underdiagnosed and can recur in renal transplant, causing graft failure...
July 22, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27435002/current-anti-myeloma-therapies-in-renal-manifestations-of-monoclonal-light-chain-associated-fanconi-syndrome-a-retrospective-series-of-49-patients
#18
M Vignon, V Javaugue, M P Alexander, K El-Karoui, A Karras, D Roos-Weil, B Royer, B Asli, B Knebelmann, G Touchard, A Jaccard, B Arnulf, F Bridoux, N Leung, J P Fermand
We retrospectively reviewed 49 patients with light chain (LC) Fanconi syndrome (FS). Patients presented with chronic kidney disease (median estimated glomerular filtration rate (eGFR) of 33 ml/min/1.73 m(2)) and tubular proteinuria. All patients tested had elevated fractional excretion of phosphate, uric acid, generalized aminoaciduria and/or normoglycemic glycosuria. Thirty-eight patients had monoclonal gammopathy of renal significance and eleven patients had an overt hematological malignancy. The monoclonal LC isotype was kappa in 46/49 cases...
January 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27271872/effects-of-treatment-of-asymptomatic-hyperuricemia-on-graft-survival-and-mortality-in-kidney-transplant-recipients
#19
Nikolaos Pagonas, Samad Kor, Felix S Seibert, Arnd Giese, Walter Zidek, Petra Reinke, Nina Babel, Frederic Bauer, Timm H Westhoff
BACKGROUND Hyperuricemia is very common after renal transplantation. It is associated with an increased risk of cardiovascular events and graft loss. To date, however, treatment is only recommended in symptomatic disease. MATERIAL AND METHODS We included 503 adult patients who underwent kidney transplantation at the Charité-Universitätsmedizin Berlin in this retrospective study. Patients were followed up for up to 120 months. All-cause mortality, graft survival, changes in level of serum uric acid (SUA), and estimated glomerular filtration rate (eGFR) were analyzed...
June 7, 2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27109968/can-solid-organ-transplanted-patients-perform-a-cycling-marathon-trends-in-kidney-function-parameters-in-comparison-with-healthy-subjects
#20
G Mosconi, M L Angelini, W Balzi, V Totti, G S Roi, M Cappuccilli, M Tonioli, D Storani, M Trerotola, A N Costa
BACKGROUND: Few solid-organ-transplanted patients (TP) perform regular sport activity. Poor data are available on the safety of intense and prolonged physical exercise on this population. The aim of the study was to evaluate kidney function parameters in a group of TP in comparison with healthy volunteers (HV) involved in a long-distance road cycling race: length 130 km and total uphill gradient, 1871 m. METHODS: Nineteen TP were recruited: 10 renal, 8 liver, and 1 heart and compared with 35 HV...
March 2016: Transplantation Proceedings
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