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Laryngeal cancer

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https://www.readbyqxmd.com/read/28806534/knockdown-of-snail-inhibits-epithelial-mesenchymal-transition-of-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-through-vdr-signaling-pathway
#1
Xue Zhao, Dan Yu, Jingpu Yang, Kai Xue, Yan Liu, Chunshun Jin
It has been well-documented that Snail plays a decisive role in various tumors. However, the direct effect of Snail on laryngeal squamous cell carcinoma (LSCC) has not been elaborated. In this study, we firstly detected the expression of Snail in 14 samples of patients with LSCC and found that its content was high in cancer tissues compared with adjacent tissues. Then we established LSCC Hep-2 cells with Snail silencing and validated the knockdown efficiency by western blotting and real-time PCR. Results showed that silencing of Snail significantly inhibited the ability of adhesion, migration, and invasion of Hep-2 cells...
August 14, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28801511/paraneoplastic-mucous-membrane-pemphigoid-with-ocular-and-laryngeal-involvement
#2
Silvia Lambiel, Pavel Dulguerov, Emmanuel Laffitte, Igor Leuchter
A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. A diagnosis of anti-laminin 5 mucous membrane pemphigoid was retained, based on skin biopsy, direct immunofluorescence and immunoprecipitation...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28795320/ezh2-promotes-cell-proliferation-by-regulating-the-expression-of-runx3-in-laryngeal-carcinoma
#3
Rong Lian, Huimin Ma, Zhiyan Wu, Guozheng Zhang, Lei Jiao, Wenjie Miao, Qianqian Jin, Ruixue Li, Ping Chen, Haixu Shi, Wenfa Yu
Enhancer of zeste homolog 2 (EZH2) is a highly conserved histone methyltransferase, which is overexpressed in different types of cancers such as breast and prostate cancer. It is reported that EZH2 can directly down-regulate RUNX3 by increasing histone H3 methylation. However, the role of EZH2 in the development and progression of laryngeal carcinoma has not yet been investigated, and the relationship between EZH2 and RUNX3 in laryngeal carcinoma is rarely reported. The current study aims to determine the role of EZH2 in the progression of laryngeal carcinoma, and investigate the interaction between EZH2 and the tumor suppressor RUNX3...
August 9, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28791831/the-role-of-human-papillomavirus-in-oncogenic-transformation-and-its-contribution-to-the-etiology-of-precancerous-lesions-and-cancer-of-the-larynx-a-review
#4
REVIEW
Katarzyna Nowińska, Urszula Ciesielska, Marzenna Podhorska-Okołów, Piotr Dzięgiel
Human papillomavirus (HPV) belongs to the Papillomaviridae family and infects squamous cells and mucous membranes of humans. Various studies conducted over the last years have shown a correlation between HPV infection and carcinogenesis process. The DNA of the virus is detected in approximately 20% of cancers of the upper respiratory tract. The presence of HPV in cancerous lesion of the larynx varies depending on the procedure applied for sample collection and the viral DNA detection method. The high variance in the frequency of HPV detection is observed even among results obtained with the use of PCR reaction...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28791411/microrna-195-inhibits-growth-and-invasion-of-laryngeal-carcinoma-cells-by-directly-targeting-dcun1d1
#5
Shuang Yu, Chao Li, Xuan Zhou, Yongwang Huang, Lun Zhang
MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression and are involved in cell biological processes. The aberrant expression of miR-195 has been found in various types of human cancer. However, the effect of miR‑195 on the initiation and development of laryngeal squamous cell carcinoma (LSCC) remains to be elucidated. Accordingly, in the present study, we detected the expression level of miR-195 in the LSCC and the normal tissues and found that miR-195 were significantly down-regulated in the LSCC tissues...
August 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28791393/elevated-expression-of-yes%C3%A2-associated-protein-is-associated-with-the-malignant-status-and-prognosis-of-laryngeal-squamous-cell-carcinoma
#6
Chunchen Pan, Zhihui Du, Zhaogen Cai, Yun Liu, Yanbo Sun, Jin Chen, Ting Tong, Qingguo Chen, Liangqiang Zhou, Dan Bing, Yanling Tao, Hanqi Chu
Previous studies have demonstrated that elevated yes‑associated protein (YAP) expression is associated with tumor aggression and poor prognosis in various types of human cancer. However, the clinicopathological significance and the prognostic value of YAP in laryngeal squamous cell carcinoma (LSCC) is unknown. The aim of the present study was to identify the expression pattern and prognostic significance of YAP in patients with LSCC. YAP mRNA and protein expression levels were examined in fresh and archived LSCC samples using the reverse transcription‑quantitative polymerase chain reaction, immunohistochemistry (IHC) and western blotting...
August 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28790865/survivorship-of-patients-with-head-and-neck-cancer-receiving-care-in-a-tertiary-health-facility-in-nigeria
#7
Vitalis C Okwor, Adeniyi F Fagbamigbe, Olufunmilayo I Fawole
BACKGROUND: Head and neck cancer (HNC) is a major clinical and public health concern worldwide which impairs the vital functions of life. The treatment of metastatic HNCs is mainly palliative. This study examined the survival patterns and treatment outcomes in patients with HNCs in a tertiary hospital in Nigeria. MATERIALS AND METHODS: A review of the case files and treatment cards of patients with histological diagnosis of HNCs seen between January 2002 and December 2011 at the Radiotherapy Department, University College Hospital, Ibadan, was conducted...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28790260/-iii-non-surgical-treatment-strategy-for-locally-advanced-laryngeal-and-hypopharyngeal-cancer
#8
Naomi Kiyota
No abstract text is available yet for this article.
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28790257/-head-and-neck-tumor-larynx-preservation-in-locally-advanced-laryngeal-and-hypopharyngeal-cancer
#9
Hidenori Inohara
No abstract text is available yet for this article.
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28771444/radiotherapy-for-t3n0-glottic-carcinoma-without-cord-fixation-elective-nodal-irradiation-or-not
#10
Ryo Toya, Ryuji Murakami, Daizo Murakami, Tetsuo Saito, Tomohiko Matsuyama, Yutaka Toya, Yasuyuki Yamashita, Natsuo Oya
BACKGROUND: Although the T3 category has been changed in the sixth edition of the TNM staging system proposed by the Union for International Cancer Control (UICC), the appropriate clinical target volume (CTV) of elective nodal irradiation (ENI) for T3N0 glottic carcinoma without cord fixation, which was formerly treated as a T1-2N0 disease, is not fully discussed. MATERIALS AND METHODS: We retrospectively analyzed 64 patients staged or restaged as T3N0 disease without cord fixation...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765949/identification-of-mirna-mrna-crosstalk-in-laryngeal-squamous-cell-carcinoma
#11
Yonghua Fei, Ping Guo, Fuling Wang, Hu Li, Yanhua Lei, Wei Li, Xuehong Xun, Fengxiang Lu
The aim of the present study was to elaborate the underlying pathogenesis of laryngeal squamous cell carcinoma (LSCC). Micro (mi) RNA and messenger (m) RNA expression profiling of patients with LSCC were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed miRNAs (DEMIs) and differentially expressed mRNAs (DEMs) were identified in LSCC compared to normal control tissues. The DEMs targeted by DEMIs were identified and the negative correlation between DEMs and DEMIs was subjected to visualization...
July 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28764811/survival-impact-of-pre-treatment-neutrophils-on-oropharyngeal-and-laryngeal-cancer-patients-undergoing-definitive-radiotherapy
#12
Whitney A Sumner, William A Stokes, Ayman Oweida, Kiersten L Berggren, Jessica D McDermott, David Raben, Diana Abbott, Bernard Jones, Gregory Gan, Sana D Karam
BACKGROUND: Squamous cell carcinoma of the head and neck (HNSCC) represents an array of disease processes with a generally unfavorable prognosis. Inflammation plays an important role in tumor development and response to therapy. We performed a retrospective analysis of HNSCC patients to explore the relationship of the lymphocyte and neutrophil counts, the neutrophil-to-lymphocyte ratio (NLR) overall survival (OS), cancer-specific survival (CSS), local control (LC) and distant control (DC)...
August 2, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28764598/two-cases-of-combination-therapy-with-cetuximab-paclitaxel-and-cisplatin-for-advanced-head-and-neck-cancer
#13
Matthew A Hoch, Kati Cousins, Ruth Nartey, Keith Riley, Megan Hartranft
Two patients diagnosed with advanced head and neck cancer were treated with cetuximab 400 mg/m(2) intravenously for one loading dose followed by 250 mg/m(2) IV on days 1, 8, and 15 along with paclitaxel 80 mg/m(2) and cisplatin 30 mg/m(2) intravenously on days 1 and 8 repeated every 21 days for three cycles (CPP). Maintenance cetuximab 250 mg/m(2) intravenously weekly was continued following the aforementioned regimen for one year or until disease progression. Patient A was diagnosed with squamous cell carcinoma of the parotid gland treated initially with parotidectomy and radiation therapy...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28761177/analysis-of-autophagy-gene-polymorphisms-in-spanish-patients-with-head-and-neck-squamous-cell-carcinoma
#14
Javier Fernández-Mateos, Raquel Seijas-Tamayo, Juan Carlos Adansa Klain, Miguel Pastor Borgoñón, Elisabeth Pérez-Ruiz, Ricard Mesía, Elvira Del Barco, Carmen Salvador Coloma, Antonio Rueda Dominguez, Javier Caballero Daroqui, Encarnación Fernández Ruiz, Juan Jesús Cruz-Hernández, Rogelio González-Sarmiento
Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28758434/-human-papillomavirus-associated-cervix-uteri-morbidity-in-hungary-epidemiology-and-correlation-with-the-hpv-types-and-the-simultaneous-cytological-diagnosis
#15
Zoltán Szentirmay, Zsuzsa Veleczki, Miklós Kásler
INTRODUCTION: Persistent infection of human papillomavirus is known to cause cervical intraepithelial neoplasia or cancer in the cervix uteri and other HPV-associated cancers in different localization. Based on epidemiological and biological data, principally the high risk HPV is responsible for development of cervical these cancers. However, we have no information about the frequently distribution of different HPV types and what is the correlation between the HPV types and cytological diagnosis in cervical intraepithelial neoplasia (CIN)...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28758200/endoscopic-screening-for-synchronous-esophageal-neoplasia-among-patients-with-incident-head-and-neck-cancer-prevalence-risk-factors-and-outcomes
#16
Yao-Kuang Wang, Yun-Shiuan Chuang, Tzung-Shiun Wu, Ka-Wo Lee, Che-Wei Wu, Hsiang-Chen Wang, Chie-Tong Kuo, Chien-Hung Lee, Wen-Rei Kuo, Chung-Ho Chen, Deng-Chyang Wu, I-Chen Wu
Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. 815 incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white-light imaging, narrow-band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected...
July 30, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28755160/successful-video-assisted-thoracoscopic-surgery-in-prone-position-in-patients-with-esophageal-cancer-and-aberrant-right-subclavian-artery-report-of-three-cases
#17
Koji Shindo, Eishi Nagai, Toshinaga Nabae, Toru Eguchi, Taiki Moriyama, Kenoki Ohuchida, Tatsuya Manabe, Takao Ohtsuka, Yoshinao Oda, Makoto Hashizume, Masafumi Nakamura
BACKGROUND: An aberrant right subclavian artery (ARSA) with an associated nonrecurrent right inferior laryngeal nerve (NRILN) is a relatively rare anomaly that occurs at a frequency of 0.3 to 2.0% of the general population. NRILN has been mainly documented in the head and neck region; it has been rarely described in patients with esophageal cancer, especially those undergoing thoracoscopic surgery. Video-assisted thoracoscopic surgery for esophageal cancer (VATS-E) is becoming more widespread as a reliable minimally invasive surgical procedure associated with reduced perioperative complications...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28752291/composition-and-abundance-of-microbiota-in-the-pharynx-in-patients-with-laryngeal-carcinoma-and-vocal-cord-polyps
#18
Hongli Gong, Boyan Wang, Yi Shi, Yong Shi, Xiyan Xiao, Pengyu Cao, Lei Tao, Yuezhu Wang, Liang Zhou
The pharynx is an important site of microbiota colonization, but the bacterial populations at this site have been relatively unexplored by culture-independent approaches. The aim of this study was to characterize the microbiota structure of the pharynx. Pyrosequencing of 16S rRNA gene libraries was used to characterize the pharyngeal microbiota using swab samples from 68 subjects with laryngeal cancer and 28 subjects with vocal cord polyps. Overall, the major phylum was Firmicutes, with Streptococcus as the predominant genus in the pharyngeal communities...
August 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28750685/osteoradionecrosis-of-the-hyoid-bone-after-intra-arterial-chemoradiotherapy-for-oropharyngeal-cancer-mr-imaging-findings
#19
Hiromitsu Hatakeyama, Noriyuki Fujima, Kazuhiko Tsuchiya, Kenji Mizoguchi, Takatsugu Mizumachi, Tomohiro Sakashita, Satoshi Kano, Akihiro Homma, Satoshi Fukuda
BACKGROUND: Osteoradionecrosis (ORN) of the hyoid bone sometimes induces severe front neck infection and can cause laryngeal stenosis and carotid rupture. Although ORN of the hyoid bone is known to be a complication of chemoradiotherapy for head and neck cancer, there has been no basis for its evaluation. Our purpose is to present the clinical and MR imaging features of ORN of the hyoid bone. METHODS: The study group comprised patients with advanced oropharyngeal cancer treated with targeted intra-arterial cisplatin infusion with concomitant radiotherapy...
July 27, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28743857/the-clinical-signification-of-claudin-11-promoter-hypermethylation-for-laryngeal-squamous-cell-carcinoma
#20
Zhisen Shen, Bing Cao, Lexi Lin, Chongchang Zhou, Dong Ye, Shijie Qiu, Qun Li, Xiang Cui
BACKGROUND Claudin-11 (CLDN11) is frequently silenced by its promoter hypermethylation. Previous studies have shown that CLDN11 promoter hypermethylation is a potential biomarker for diagnosing various cancers. The aim of this study was to investigate CLDN11 promoter methylation and its potential relevance to clinicopathologic features and prognosis of patients with laryngeal squamous cell carcinoma (LSCC). MATERIAL AND METHODS Using the quantitative methylation-specific polymerase chain reaction (qMSP), CLDN11 promoter methylation was measured in 91 tumor tissues and their paired adjacent normal tissues, and the relationship between CLDN11 methylation and clinicopathologic features was evaluated...
July 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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