keyword
MENU ▼
Read by QxMD icon Read
search

Laryngeal cancer

keyword
https://www.readbyqxmd.com/read/27920556/the-prognostic-value-of-systemic-and-local-inflammation-in-patients-with-laryngeal-squamous-cell-carcinoma
#1
Jie Wang, Shengzi Wang, Xinmao Song, Wenjiao Zeng, Shuyi Wang, Fu Chen, Hao Ding
BACKGROUND: Cancer-related systemic inflammation has been demonstrated to be associated with poor outcome in multiple types of cancers. Meanwhile, the local inflammation, which is characterized by dense intratumoral immune infiltrate, is a favorable predictor of survival outcome. PURPOSE: To evaluate the role of systemic and local inflammation in predicting outcome in patients with laryngeal squamous cell carcinoma. PATIENTS AND METHODS: In this retrospective study, 120 patients who had undergone postoperative radiotherapy were enrolled...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27918783/association-between-laryngeal-cancer-and-asbestos-exposure-a-systematic-review
#2
Ashley P O'Connell Ferster, Jane Schubart, Yesul Kim, David Goldenberg
Importance: It has been debated whether a link exists between laryngeal cancer and asbestos exposure. Prior systematic reviews have been conducted on this topic, but no updates have been performed on the most recent literature since 2000. Objective: To provide an updated systematic review of the association between laryngeal cancer and asbestos exposure. Evidence Acquisition: A search of electronic databases, including PubMed and the Cochrane Library, was performed for articles published between January 1, 2000, and April 30, 2016...
December 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27916417/ccl20-ccr6-promotes-cell-proliferation-and-metastasis-in-laryngeal-cancer-by-activating-p38-pathway
#3
Eryong Lu, Jili Su, Yanhui Zhou, Chao Zhang, Yuehui Wang
Chemokine and its receptors play important roles in laryngeal cancer development and progression. CCR6 is the receptor of CCL20 chemokine, but its function in laryngeal cancer is not known. The aim of this study is to explore the roles of CCR6 and its regulation mechanism in laryngeal cancer. We found CCR6 expression was higher in laryngeal cancer tissues compared with their normal controls, so did in laryngeal cancer cells. Cellular function indicated that down-regulation of CCR6 in laryngeal cancer cells could suppress cell proliferation and metastasis...
December 1, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27916282/repair-of-complex-pharyngocutaneous-fistula-using-a-staged-temporoparietal-fascial-flap
#4
Nicholas B Abt, Priya Srikanth, Sidharth V Puram, Daniel G Deschler
INTRODUCTION: PCF is the most common major complication after salvage total laryngectomy (TL), especially for previously irradiated patients with laryngeal or hypopharyngeal cancer. METHODS/RESULTS: A 65-year-old woman presented with recurrent bilateral supraglottic SCC requiring salvage TL 5.5years after initial T1N0M0 epiglottic SCC resection. Her post-operative course was complicated by PCF development one month post-operatively and surgical fistula closure was delayed for adjuvant chemoradiotherapy...
November 25, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27910227/preoperative-computed-tomography-diagnosis-of-non-recurrent-laryngeal-nerve-in-patients-with-esophageal-carcinoma
#5
Zhong-Xi Niu, Hang Zhang, Long-Qi Chen, Hui Shi, Jun Peng, Li-Wei Su, Wei Li, Bo Xiao, Shu He, Hong-Xu Yue
BACKGROUND: The non-recurrent laryngeal nerve (NRLN) is a rare but potentially serious anomaly that is commonly associated with the aberrant right subclavian artery (ARSA). It is easy to damage during surgical resection of esophageal cancer, leading to severe complications. METHODS: Preoperative enhanced thoracic computed tomography (CT) scans of 2697 patients with esophageal carcinoma treated in our hospital between January 2010 and December 2013 were examined...
December 2, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27909719/the-expression-and-function-of-epithelial-membrane-protein-1-in-laryngeal-carcinoma
#6
Hong Li, Xiaowen Zhang, Xuejun Jiang, Xu Ji
In this study, we compared the expression of epithelial membrane protein 1 (EMP1) on the steady-state mRNA level (by quantitative real-time PCR) and on the protein level (by western immunoblot and immunohistochemistry) in 51 pairs of laryngeal carcinoma tissues and matched cancer-free peritumor tissues, and we analyzed the correlation between EMP1 expression and different clinicopathological factors. Furthermore, we ectopically expressed EMP1 in human laryngeal carcinoma Hep-2 cells and examined the effects on cell viability, apoptosis, colonogenicity, and motility, by MTT assay, flow cytometry, colony formation assay and Transwell migration assay, respectively...
November 28, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27906459/integrative-genomic-analysis-identifies-ancestry-related-expression-quantitative-trait-loci-on-dna-polymerase-%C3%AE-and-supports-the-association-of-genetic-ancestry-with-survival-disparities-in-head-and-neck-squamous-cell-carcinoma
#7
Meganathan P Ramakodi, Karthik Devarajan, Elizabeth Blackman, Denise Gibbs, Danièle Luce, Jacqueline Deloumeaux, Suzy Duflo, Jeffrey C Liu, Ranee Mehra, Rob J Kulathinal, Camille C Ragin
BACKGROUND: African Americans with head and neck squamous cell carcinoma (HNSCC) have a lower survival rate than whites. This study investigated the functional importance of ancestry-informative single-nucleotide polymorphisms (SNPs) in HNSCC and also examined the effect of functionally important genetic elements on racial disparities in HNSCC survival. METHODS: Ancestry-informative SNPs, RNA sequencing, methylation, and copy number variation data for 316 oral cavity and laryngeal cancer patients were analyzed across 178 DNA repair genes...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27902867/predictive-factors-and-treatment-outcome-of-laryngeal-carcinoma-recurrence
#8
Aaro Haapaniemi, Janne Väisänen, Timo Atula, Olli-Pekka Alho, Antti Mäkitie, Petri Koivunen
BACKGROUND: Up to 30% of patients with laryngeal squamous cell carcinoma (SCC) present with recurrence after treatment. We analyzed factors associated with the risk of cancer recurrence and prognosis after recurrence. METHODS: A nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005 with initial successful therapy (n = 316) was analyzed. RESULTS: Laryngeal SCC recurred in 22% of patients. The median time to recurrence was 9 months, with 90% occurring within 36 months after treatment...
November 30, 2016: Head & Neck
https://www.readbyqxmd.com/read/27902487/identification-of-laryngeal-cancer-prognostic-biomarkers-using-an-inflammatory-gene-related-competitive-endogenous-rna-network
#9
Qun He, Linli Tian, Hao Jiang, Jiarui Zhang, Qiang Li, Yanan Sun, Jiannan Zhao, Huijun Li, Ming Liu
Competitive endogenous RNAs (ceRNAs) act as molecular sponges for microRNAs (miRNAs), and are associated with tumorigenesis in various cancers, including laryngeal cancer (LC). In this work, we constructed an LC-specific inflammatory gene-related ceRNA network (IceNet). In IceNet, ceRNAs targeting inflammation-related genes tended to be network hubs. Additionally, the betweenness centralities of these hub ceRNAs were higher than those of the inflammation-related genes themselves, indicating that the hub ceRNAs in this study played critical roles in communication between IceNet molecules...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898173/an-update-on-larynx-cancer
#10
REVIEW
Conor E Steuer, Mark El-Deiry, Jason R Parks, Kristin A Higgins, Nabil F Saba
Answer questions and earn CME/CNE Laryngeal cancer remains one of the most common tumors of the respiratory tract. Fortunately, significant advancements have been made over the past decade in the treatment of laryngeal cancer. Although surgery has been the historical mainstay for localized disease and still is an integral part of treatment, nonsurgical options like radiation and systemic therapy have emerged as viable options. In addition, in the metastatic setting, novel agents are showing promise for this patient population...
November 29, 2016: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/27895741/the-prognostic-significance-of-estrogen-receptor-%C3%AE-in-head-and-neck-squamous-cell-carcinoma
#11
Kresimir Grsic, Iva Ledinsky Opacic, Sanda Sitic, Marija Milkovic Perisa, Petar Suton, Bozena Sarcevic
Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer in the world. Although multimodal and targeted therapy is now used in therapeutic procedures, the survival of patients with HNSCC has remained unchanged over the last 30 years. A number of studies have demonstrated that the increased expression of intranuclear ERβ in breast, lung and colon cancer is a favorable prognostic marker associated with higher survival rates. However, the clinical significance of sex hormone receptors in HNSCC remains unclear...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27893554/stapler-esophageal-closure-during-total-laryngectomy
#12
Onur Ismi, Murat Unal, Yusuf Vayisoglu, Mesut Yesilova, Ilter Helvaci, Kemal Gorur, Cengiz Ozcan
Mechanical esophageal closure with stapler during total laryngectomy has been used by various authors to decrease the surgical time and pharyngocutaneous fistula (PCF) rates. In a few of the studies, surgical site infection (SSI) rates are mentioned and none of the studies emphasize the effect of decreased surgical time on postoperative cardiovascular and cerebrovascular complications. In this study, the authors compared the PCF rates, SSI rates, operation times between 30 mechanical stapler and 40 manual esophageal closure during total laryngectomy for laryngeal cancer patients...
November 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27889234/in-silico-and-in-vitro-anti-cancer-potential-of-a-curcumin-analogue-1e-6e-1-7-di-1h-indol-3-yl-hepta-1-6-diene-3-5-dione
#13
Shamim Akhtar Sufi, Lakshmi Narayana Adigopula, Safiulla Basha Syed, Victor Mukherjee, Mohane S Coumar, H Surya Prakash Rao, Rukkumani Rajagopalan
PURPOSE: Previously we showed that BDMC, an analogue of curcumin suppresses growth of human breast and laryngeal cancer cell line by causing apoptosis. Here, we demonstrate the enhanced anti-cancer activity of a heterocyclic ring (indole) incorporated curcumin analogue ((1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-Dione), ICA in short, in comparison to curcumin. METHOD: ICA was synthesized by a one pot condensation reaction. Anti-cancer potential of ICA was assessed in three human cancer cell lines of different origin (Lung adenocarcinoma (A549), leukemia (K562) and colon cancer (SW480)) by MTT assay...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27888826/clinical-significance-of-ki-67-c-erbb-2-and-e-cadherin-expressions-in-open-partial-laryngectomy-patients
#14
Ozan Barutçu, Medine Kara, Aslı Muratlı, Oğuz Güçlü, Sefa Dereköy
OBJECTIVES: This study aims to analyze the correlation between biomarkers and risks of cervical lymph node invasion, recurrence, distant metastasis and survival regarding the clinicopathological variables in laryngeal cancers. PATIENTS AND METHODS: Forty-one patients with laryngeal cancers were examined retrospectively. The correlations evaluated between E-cadherin, Ki-67, c-erbB-2 expressions, tumor site, differentiation, the risk of cervical lymph node metastasis, perineural, perivascular, pericapsular invasion and recurrence as well as survival time...
September 2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/27885426/prospective-cohort-study-assessing-chronic-pain-in-patients-following-minor-surgery-for-breast-cancer
#15
Régis Fuzier, Floriane Puel, Philippe Izard, Agnès Sommet, Sébastien Pierre
PURPOSE: Pain after tumorectomy and sentinel lymph node dissection is poorly reported in the literature. We carried out a prospective survey aimed at assessing pain three months after such minor surgery for breast cancer. METHODS: The study was approved by the local ethics committee. Most surgeries followed a standard protocol involving general anesthesia with no regional analgesia technique, laryngeal mask, sufentanil and propofol for induction, and multimodal analgesia during the postoperative period...
November 24, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27882174/reduction-of-p38-mitogen-activated-protein-kinase-and-cyclooxygenase-2-signaling-by-isoflurane-inhibits-proliferation-and-apoptosis-evasion-in-human-papillomavirus-infected-laryngeal-papillomas
#16
Hongbo Ren, Xiaojuan Shi, Ying Li
Human laryngeal papilloma (LP) is a human papillomavirus-induced hyperplastic tumor of the respiratory tract, which is characterized by rapid growth and apoptosis resistance. Isoflurane (ISO) inhibits proliferation and elicits apoptosis in cancer cells. The results of the present study found that the mRNA and protein levels of cyclooxygenase-2 (COX2) were higher in LP tissues than in normal laryngeal samples, and prostaglandin E2 (PGE2) production was increased in LP cells, as determined by quantitative polymerase chain reaction, western blot and radioimmunoassay analyses...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27882007/therapeutic-effects-of-sequential-chemoradiotherapy-with-pemetrexed-and-cisplatin-on-locally-advanced-laryngeal-cancer
#17
Youmao Tao, Chong Ma, Xiangdang Yin, Xuedong Fang, Lixiu Liu
OBJECTIVE: To explore the therapeutic effects of sequential chemoradiotherapy with pemetrexed and cisplatin on locally advanced laryngeal cancer (LALC). METHODS: Fifty LALC patients who were treated in our hospital between January 2010 and January 2012 were selected and randomly divided into an observation group and a control group (n=25). The two groups were given conventional radiotherapy in the same manner, before which two cycles of chemotherapy were performed...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27880721/inhibition-of-hax-1-by-mir-125a-reverses-cisplatin-resistance-in-laryngeal-cancer-stem-cells
#18
Jiajia Liu, Qinglai Tang, Shisheng Li, Xinming Yang
Chemoresistance is a major obstacle in chemotherapy of laryngeal carcinoma. Recently, studies indicate that cancer stem cells are responsible for chemotherapy failure. In addition, microRNAs play important roles in tumor initiation, development and multidrug resistance. In the present study, we found that the expression of microRNA-125a was decreased in laryngeal carcinoma tissues and Hep-2 laryngeal cancer stem cells (Hep-2-CSCs). MicroRNA-125a gain-of-function significantly increased the sensitivity of Hep-2-CSCs to cisplatin in vitro and in vivo...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27874955/expression-and-significances-of-mirna-let-7-and-hmga2-in-laryngeal-carcinoma
#19
F-C Song, Y Yang, J-X Liu
OBJECTIVE: High mobility group protein A2 (HMGA2) is a reported new oncogene been regulated by tumor suppressor microRNA Let-7. HMGA2 has become a hot topic in fundamental and clinical research of laryngeal carcinoma. The aim of the current study is to investigate the molecular mechanism of Let-7 and HMGA2 in oncogenesis and progression of laryngeal cancer. PATIENTS AND METHODS: We used quantitative RT-PCR to detect the expression of miRNA Let-7a and HMGA2 mRNA from 59 pairs of fresh laryngeal cancer tissues and adjacent tissues collected for the laryngeal cancer patient...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27865371/assessing-head-and-neck-cancer-patient-preferences-and-expectations-a-systematic-review
#20
REVIEW
Pierre Blanchard, Robert J Volk, Jolie Ringash, Susan K Peterson, Katherine A Hutcheson, Steven J Frank
INTRODUCTION: To enhance the value of care, interventions should aim at improving endpoints that matter to patients. The preferences of head and neck cancer patients regarding treatment outcomes are therefore a major topic for patient-centered research. METHODS: A systematic review (PROSPERO number CRD42016035692) was conducted by searching electronic databases (Medline, Embase, Cochrane, CINAHL) for articles evaluating patient or surrogate preferences in head and neck cancer...
November 2016: Oral Oncology
keyword
keyword
7819
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"