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Laryngeal cancer

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https://www.readbyqxmd.com/read/28921460/nfbd1-mdc1-participates-in-the-regulation-of-proliferation-and-apoptosis-in-human-laryngeal-squamous-cell-carcinoma
#1
X Liu, Z Qiu, Z Wang, W Zuo, Z Gong, C Liu, Q Zeng, Y Qian, L Jiang, Y Li, Y Bu, G Hu
PURPOSE: The objective of the study was to investigate the role of NFBD1 in the proliferation and apoptosis of laryngeal squamous cell carcinoma (LSCC) cells. METHODS: Immunohistochemistry (IHC) and qRT-PCR was employed to determine the expressions of NFBD1 protein and mRNA in LSCC tissues and adjacent noncancerous tissues. After the downregulation of NFBD1 expression, the colony formation assay, MTS assay and apoptosis assay were used to investigate the changes in the proliferation and apoptosis of Hep2 cells...
September 18, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28919747/ge11-peptide-conjugated-nanoliposomes-to-enhance-the-combinational-therapeutic-efficacy-of-docetaxel-and-sirna-in-laryngeal-cancers
#2
Wei-Wei Xu, Da-Yu Liu, Ying-Chun Cao, Xiang-Yun Wang
In this study, dual therapeutic-loaded GE11 peptide-conjugated liposomes were developed and applied to enhance therapeutic efficacies of standard-of-care regimens for the treatment of laryngeal cancer. The therapeutic strategy used here was a combination treatment with the chemotherapeutic docetaxel (DTX) and siRNA against the ABCG2 gene that regulates multidrug resistance in many tumor types. Liposome-encapsulated DTX/ABCG2-siRNA molecules were targeted to recognize tumor cells of squamous morphology by conjugation to the EGFR-targeting ligand, GE11...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28901478/microrna%C3%A2-195-inhibits-cell-proliferation-migration-and-invasion-in-laryngeal-squamous-cell-carcinoma-by-targeting-rock1
#3
Yang Liu, Jixiang Liu, Lin Wang, Xiangli Yang, Xiang Liu
Laryngeal carcinoma is the second most common malignancy of the head and neck cancers. The most common type of laryngeal carcinoma comprises laryngeal squamous cell carcinoma (LSCC), which accounts for ~95% of laryngeal carcinoma cases. Despite great progress in diagnostic and therapeutic techniques over the last few decades, the prognosis for patients with LSCC remains poor. A number of studies reported that various miRNAs are dysregulated in LSCC and serve critical roles in LSCC tumorigenesis and tumor development...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28901032/role-of-routine-post-operative-laryngeal-endoscopic-assessment-after-lung-cancer-surgery
#4
EDITORIAL
Chong-Kin Liam
No abstract text is available yet for this article.
September 12, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28900521/effectiveness-of-ultrasonography-and-computed-tomography-in-assessing-thyroid-cartilage-invasion-in-laryngeal-and-hypopharyngeal-cancers
#5
Nilu Malpani Dhoot, B Choudhury, A C Kataki, L Kakoti, S Ahmed, J Sharma
OBJECTIVE: To evaluate the adequacy of ultrasonography (US) and computed tomography (CT) in the assessment of thyroid cartilage invasion in patients with airway cancer. MATERIALS AND METHODS: Sixty-two consecutive patients referred to our institute underwent US and CT to stage laryngeal (n = 27) or hypopharyngeal (n = 35) cancer in this prospective study. Two radiologists, who were blinded to the patients' clinical histories and histopathology, evaluated thyroid cartilage invasion on US and CT separately and independently...
September 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28899969/tmem16a-ano1-inhibits-apoptosis-via-down-regulation-of-bim-expression
#6
Neal R Godse, Nayel I Khan, Zachary A Yochum, Roberto Gomez-Casal, Carolyn Kemp, Daniel J Shiwarski, Raja Seethala, Scott Kulich, Mukund Seshadri, Timothy F Burns, Umamaheswar Duvvuri
PURPOSE: TMEM16A is a calcium-activated chloride channel that is amplified in a variety of cancers, including 30% of head and neck squamous cell carcinomas (HNSCC), raising the possibility of an anti-apoptotic role in malignant cells. The present study investigated this using a multi-modal, translational investigation. EXPERIMENTAL DESIGN: Combination of 1) in vitro HNSCC cell culture experiments assessing cell viability, apoptotic activation, and protein expression 2) in vivo studies assessing similar outcomes, and 3) molecular and staining analysis of human HNSCC samples...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28898958/radiotherapy-for-laryngeal-cancer-technical-aspects-and-alternate-fractionation
#7
Hideya Yamazaki, Gen Suzuki, Satoaki Nakamura, Ken Yoshida, Koji Konishi, Teruki Teshima, Kazuhiko Ogawa
Early laryngeal, especially glottic, cancer is a good candidate for radiotherapy because obvious early symptoms (e.g. hoarseness) make earlier treatment possible and with highly successful localized control. This type of cancer is also a good model for exploring the basic principles of radiation oncology and several key findings (e.g. dose, fractionation, field size, patient fixation, and overall treatment time) have been noted. For example, unintended poor outcomes have been reported during transition from 60Cobalt to linear accelerator installation in the 1960s, with usage of higher energy photons causing poor dose distribution...
July 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28895160/oncologic-outcomes-of-ktp-laser-surgery-versus-radiation-for-t1-glottic-carcinoma
#8
Jamal Ahmed, Ahmed Sherif Gabr Ibrahim, Laura M Freedman, David E Rosow
OBJECTIVES/HYPOTHESIS: To characterize outcomes for patients who underwent transoral microsurgery with potassium titanyl phosphate (KTP) laser resection of early glottic cancers and to compare outcomes with patients who received external beam radiation therapy. STUDY DESIGN: Retrospective cohort study. METHODS: The history of patients with T1 glottic carcinoma treated with curative primary radiation or transoral KTP laser resection was reviewed...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28895157/laryngeal-exposure-and-margin-status-in-glottic-cancer-treated-by-transoral-laser-microsurgery
#9
Cesare Piazza, Alberto Paderno, Paola Grazioli, Francesca Del Bon, Nausica Montalto, Pietro Perotti, Riccardo Morello, Marta Filauro, Piero Nicolai, Giorgio Peretti
OBJECTIVE: Laryngeal exposure is one of the most limiting factors in transoral laser microsurgery (TLM) for glottic cancer. We evaluated the correlation between the degree of laryngeal exposure, as assessed by an easy previously described scoring tool (Laryngoscore), and histopathologic surgical margin status after TLM. STUDY DESIGN: Prospective evaluation of 147 patients affected by Tis-T2 glottic cancer treated by TLM with curative intent between January 2012 and April 2016...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28894270/a-novel-role-for-nanog-as-an-early-cancer-risk-marker-in-patients-with-laryngeal-precancerous-lesions
#10
Juan P Rodrigo, M Ángeles Villaronga, Sofía T Menéndez, Francisco Hermida-Prado, Miquel Quer, Isabel Vilaseca, Eva Allonca, Daniel Pedregal Mallo, Aurora Astudillo, Juana M García-Pedrero
NANOG is a master regulator of embryonic stem cell pluripotency, found to be frequently aberrantly expressed in a variety of cancers, including laryngeal carcinomas. This study investigates for the first time the role of NANOG expression in early stages of laryngeal tumourigenesis and its potential utility as cancer risk marker. NANOG protein expression was evaluated by immunohistochemistry using two large independent cohorts of patients with laryngeal precancerous lesions, and correlated with clinicopathological parameters and laryngeal cancer risk...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891087/elucidation-of-salvage-laryngectomy-pathologic-and-clinical-variables-to-guide-further-treatment-intensification-investigation
#11
Joseph Scharpf, Matthew Ward, David Adelstein, Shlomo Koyfman, Mingsi Li
OBJECTIVE/HYPOTHESIS: There are limited treatment options beyond surgical salvage for patients who fail nonoperative treatment for laryngeal squamous cell carcinoma. In this study, we examine the failure patterns after surgical salvage and the potential pathologic and clinical prognostic variables that might guide further postoperative intensification investigation. STUDY DESIGN: Retrospective analysis at a tertiary academic referral center. METHODS: From an institutional review board-approved institutional head and neck cancer registry, a consecutive series of 147 patients who underwent salvage laryngectomy for squamous cell cancer recurrence or persistence after radiotherapy with or without chemotherapy between May 1995 and May 2016 were identified...
September 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28890828/radiation-induced-gastroparesis-case-report-and-literature-review
#12
Pierre Annede, Caroline Prieux-Klotz, Thomas Dubergé, Cyrus Chargari, Olivier Gisserot, Jean-Pierre de Jaureguiberry
Radiation induced gastroparesis as well as the other autonomic nervous system radiation induced neuropathies are poorly described in the literature. A case of gastroparesis associated with phrenic and recurrent laryngeal nerves paralysis was observed in a 69-year old patient. She was already treated two times by rachis radiotherapy in a context of breast cancer with bone metastases. Anatomical and chronological correlation of lesions, concomitant nerve damage in the radiation fields and elimination of the main differential diagnoses allowed us to link this case of gastroparesis with the background of radiotherapy...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28881887/learning-curve-for-robotic-esophagectomy-and-dissection-of-bilateral-recurrent-laryngeal-nerve-nodes-for-esophageal-cancer
#13
S Y Park, D J Kim, D R Kang, S J Haam
Dissection of bilateral recurrent laryngeal nerve (RLN) nodes is a technically demanding procedure, but robotic systems have been useful for RLN node dissection. This retrospective study investigated the learning curve for bilateral RLN node dissection in esophageal-cancer patients using a robotic system for esophageal cancer. We retrospectively reviewed 33 consecutive patients who received a robotic esophagectomy and total lymphadenectomy by single surgeon. The patients were divided into either group 1 (initial 20 cases) or group 2 (later 13 cases)...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28878571/ribonucleic-acid-interference-knockdown-of-il-6-enhances-the-efficacy-of-cisplatin-in-laryngeal-cancer-stem-cells-by-down-regulating-the-il-6-stat3-hif1-pathway
#14
Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu, Tingyan Liu
BACKGROUND: Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether interleukin-6 (IL-6) knockdown may enhance the efficacy of cisplatin in laryngeal cancer stem cells (CSC) and the potential involvement of the signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF1) in this effect. METHODS: The ALDH+ and CD44+ CSC in Hep2 human laryngeal squamous cancer cells were identified by the fluorescence-activated cell sorting technique...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28875745/age-adjusted-charlson-comorbidity-index-predicts-prognosis-of-laryngopharyngeal-cancer-treated-with-radiation-therapy
#15
Kazuya Takemura, Yukinori Takenaka, Naoki Ashida, Kotaro Shimizu, Ryohei Oya, Takahiro Kitamura, Yoshifumi Yamamoto, Atsuhiko Uno
OBJECTIVES: To examine the ability of comorbidity indices to predict the prognosis of laryngopharyngeal cancer and their association with treatment modalities. METHODS: This retrospective study included 198 patients with laryngeal, hypopharyngeal, and oropharyngeal cancers. The effect of comorbidity indices on overall survival between surgery and (chemo)-radiation therapy ((C)RT) groups was analyzed. The cumulative incidence rates for cancer mortality and other mortalities according to the age-adjusted Charlson Comorbidity Index (ACCI) and Charlson Comorbidity Index (CCI) were compared...
September 6, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28872157/laryngectomy-what-is-the-impact-of-the-type-of-surgery-on-life-quality-and-sexual-function
#16
F Akil, U Yollu, S F Toprak, M Ayral
The purpose of this study is to compare total and partial larygectomy on private life functions and sexuality in patients with laryngeal cancer. The study included 31 partial laryngectomy patients (Group 1) and 51 total laryngectomy patients (Group 2) who were operated for laryngeal cancer. European Organization for Research and Treatment of Cancer (EORTC) head and neck cancer module (QLQ-H&N35) and Arizona Sexual Experiences Scale (ASEX) forms were filled in by interviewing face to face with patients. HNSW (swallowing), HNSE (senses), HNSP (speech), HNSO (social eating), HNSX (sexuality), HNTE (problems with teeth), HNOM (problems with opening mouth) and HNCO (coughing) scores of EORTC QLQ-H&N35 were significantly higher in group 2 than in group 1...
August 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28871957/-expression-of-brca2-in-tumor-tissues-in-patients-with-laryngeal-squamous-cell-carcinoma-and-its-clinical-significance
#17
Xingbo He, Chuan Liu, Zhihai Wang, Zhitao Gong, Guohua Hu
Objective To determine the role of breast cancer susceptibility gene 2 (BRCA2) in laryngeal squamous cell carcinoma and investigate its clinical implication. Methods The expression of BRCA2 was examined by immunohistochemistry in 62 tissues of pathologically identified laryngeal squamous cell carcinoma and 23 tissues of vocal fold polyp. The relationships between BRCA2 expression and clinicopathological characteristics were further analyzed. The expression of BRCA2 mRNA and protein were detected by real-time quantitative PCR (qRT-PCR) and Western blot analysis in pathologically identified laryngeal squamous cell carcinoma tissues and corresponding normal tissues...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28870055/-lymph-node-metastasis-and-prognostic-factors-for-t1-esophageal-cancer
#18
X F Duan, X B Shang, P Tang, H J Jiang, L Gong, J Yue, M Q Ma, Z T Yu
Objective: To evaluate the lymph node metastasis (LNM) pattern and related prognostic factors for T1 esophageal cancer. Methods: Clinical data of 143 cases of pT1 esophageal cancer patients (120 male and 23 female patients with median age of 60 years) who underwent esophagectomy and lymph node resection during January 2011 and July 2016 at the Department of Esophageal Cancer of Tianjin Medical University Cancer Institute and Hospital were reviewed, including 50 cases of T1a patients and 93 cases of T1b patients...
September 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28869196/-role-of-induction-chemotherapy-in-head-and-neck-cancer-cons
#19
F Huguet, U Schick, Y Pointreau
The treatment of locally advanced head and neck squamous cell carcinoma is based on concomitant chemoradiotherapy. A sequential treatment combining induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF), followed by (chemo)radiotherapy is frequently used as part of laryngeal preservation strategies. Apart from this particular situation, the benefit in terms of survival of induction chemotherapy has been much discussed in recent years. In five recent randomized trials, chemoradiotherapy was compared with TPF induction chemotherapy followed by chemoradiotherapy...
August 28, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28868026/ultrasound-guided-transoral-videolaryngoscopic-surgery-for-retropharyngeal-lymph-node-metastasis-of-papillary-thyroid-cancer
#20
Kazunori Fujiwara, Takahiro Fukuhara, Satoshi Koyama, Ryohei Donishi, Hideyuki Kataoka, Hiroya Kitano, Hiromi Takeuchi
BACKGROUND: Endoscopic-assisted transoral surgery, including transoral robotic surgery for metastatic retropharyngeal lymph node (RPN) from well-differentiated thyroid cancer, has been reported to reduce the complications resulting from transcervical and transmandibular approaches. However, the narrow working space and difficulty identifying RPN are problematic. To solve these issues, several studies have used intraoperative ultrasound in endoscopic-assisted transoral surgery. However, the type of ultrasonography suitable for this purpose remains unclear...
May 2017: Case Reports in Oncology
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