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Laryngeal cancer

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https://www.readbyqxmd.com/read/29151175/demographic-clinical-lifestyle-related-and-social-cognitive-correlates-of-physical-activity-in-head-and-neck-cancer-survivors
#1
Laurien M Buffart, Remco de Bree, Martine Altena, Sophie van der Werff, Constance H C Drossaert, Caroline M Speksnijder, Michiel W van den Brekel, Harriët Jager-Wittenaar, Neil K Aaronson, Martijn M Stuiver
PURPOSE: The purpose of the study is to identify demographic, clinical, lifestyle-related, and social-cognitive correlates of physical activity (PA) intention and behavior in head and neck cancer (HNC) survivors using the theory of planned behavior (TPB). METHODS: Data from two cross-sectional studies on correlates of PA in HNC survivors were pooled. Both studies used self-reports to assess PA and social-cognitive correlates. Potential correlates were collected via self-report or medical records...
November 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29147004/dose-de-escalation-to-the-normal-larynx-using-conformal-radiotherapy-reduces-toxicity-while-maintaining-oncologic-outcome-for-t1-t2-glottic-cancer
#2
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
We evaluated the efficacy of dose de-escalation to the normal larynx using conformal radiotherapy (CRT) for T1/T2 glottic cancer. For conventional RT (2DRT, n = 38), the laryngeal box received a median equivalent dose in 2 Gy fractions (EQD2) of 66 Gy. For CRT (n = 42; 3D-CRT, 20; intensity-modulated RT, 22), clinical target volume (CTV)1 (gross tumor with a 3-mm margin) and CTV2 (laryngeal box) received median EQD2s of 66.6 Gy and 52.2 Gy, respectively. With a 71-month median follow-up, five-year local control and overall survival rates for 2DRT vs...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29143362/microrna-26a-inhibits-proliferation-and-tumorigenesis-via-targeting-cks2-in-laryngeal-squamous-cell-carcinoma
#3
Zhiyan Wu, Baocai Lu, Xiao Li, Wenjie Miao, Jin Li, Yongjuan Shi, Wenfa Yu
Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck cancer, with high mortality and incidence. MicroRNA-26a (miR-26a) is involved in the development and progression of several tumors. However, the roles of miR-26a and its target CKS2 in LSCC progression are not yet clear. The mRNA and protein expression was determined using RT-PCR and Western blotting assay, respectively. Cell proliferation was detected using a Cell Counting kit-8 assay (CCK-8). Transwell assay was used to evaluate cell migration and invasion...
November 16, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29141306/-methods-and-advances-in-the-research-of-lymphatics-in-the-head-and-neck
#4
R Guo, J Tian, Y Jia, P F He, R X Jin, J Guo, B Q Wang
The lymphatic system plays an important role in human health and disease. In addition to a role in the immune response, the lymphatics can also serve as a pathway for cancer metastasis.Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers.In the case where the primary focus has been controlled, cervical lymph node metastasis is one of the most important factors affecting the prognosis of head and neck cancer.Thus, understanding the anatomy of the lymphatic system is of paramount importance in predicting cancer metastasis and to perform proper lymph node dissection in cancer patients...
November 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29141300/-pet-ct-suggested-laryngeal-cancer-with-bone-metastasis-but-diagnosed-with-multiple-myeloma
#5
C L Zhao, W W Zou, J W Sun, X J Cai, J X Zhang
No abstract text is available yet for this article.
November 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29137654/conventional-fractionation-should-not-be-the-standard-of-care-for-t2-glottic-cancer
#6
Lynne M Dixon, Catriona M Douglas, Shazril Imran Shaukat, Kate Garcez, Lip Wai Lee, Andrew J Sykes, David Thomson, Nicholas J Slevin
BACKGROUND: The aim of this study was to report outcomes and late toxicity following hypofractionated accelerated radiotherapy for T2 glottic cancers. We highlight the importance of hypofractionated treatments with shorter overall treatment times, in improving outcomes for T2 glottic cancers. We also compare the biologically effective dose of hypofractionated regimes, with conventional fractionation. METHODS: One hundred twelve patients with T2 glottic cancer were treated between January 1999 and December 2005...
November 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29136734/-functional-recovery-after-recurrent-laryngeal-nerve-injury-on-different-electromyography-thresholds-during-thyroid-surgery
#7
X L Liu, C L Li, Y S Zhao, H Sun
Objective: To discuss the functional recovery after recurrent laryngeal nerve injury (RLNI) on different electromyography thresholds during thyroid surgery. Methods: The prospective experimentally were induced in 12 acute recurrent laryngeal traction animals (porcine) from December 2014 to December 2015, the amplitude and latency of electromyography, even time course during RLNI and recovery of 24 recurrent laryngeal nerves(RLN) were continuous intraoperative neuromonitoring(IONM), including 12 RLN releasing traction after 50% amplitude decrease (AD) and other 12 RLN after 70% AD...
November 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29135403/a-case-of-relapsing-polychondritis-mimicking-lung-cancer
#8
Fatma Canbay, Aydın Yılmaz, Ayperi Öztürk, Zafer Aktaş, Ebru Tatcı
Relapsing polychondritis (RP) is a rare autoimmune disease, characterized by episodic inflammatory attacks on cartilaginous tissue. Elastic cartilage of the ears and nose, hyaline cartilage of the peripheral joints, vertebral fibrocartilage, tracheobronchial cartilage, and tissues rich in proteoglycan such as those in the eyes, heart, blood vessels, and inner ear are more likely to be affected. A 35-year-old male presented with complaints of hoarseness, tinnitus and dyspnea for 19 years, with a history of several diagnostic and therapeutic interventions for laryngeal and respiratory tract...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29135113/minichromosome-maintenance-mcm-protein-4-overexpression-is-a-potential-prognostic-marker-for-laryngeal-squamous-cell-carcinoma
#9
Jianfeng Han, Meng Lian, Jugao Fang, Honggang Liu, Ru Wang, Jie Zhai, Yi Fan Yang, Ling Fen, Qian Shi, Hong Zhi Ma, Juan Sun, Zhihong Ma
PURPOSE: The minichromosomal maintenance (MCM) proteins are involved in the initiation and DNA replication. The role of MCM4 remains to be elucidated. The purpose of this study was to investigate the effects of MCM4 in laryngeal squamous cell carcinoma (LSCC) cell growth and apoptosis. METHODS: LSCC cell line UMSCC 5 was used in this study. The small interfering RNA (siRNA) of MCM 4 gene was used to identify the effects of MCM4 on the proliferation and apoptosis using methylimidazole tetrazolium (MTT) assay and flow-cytometry, respectively...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29119321/conservative-treatment-for-advanced-t3-t4-laryngeal-cancer-meta-analysis-of-key-oncological-outcomes
#10
REVIEW
Giuditta Mannelli, Maria Silvia Lazio, Paolo Luparello, Oreste Gallo
GOAL: Controversies exist regarding the treatment of advanced laryngeal carcinomas. The purpose of this systematic review was to evaluate the oncologic outcomes of both transoral laser and open partial laryngectomies for advanced (T3-T4) squamous cell laryngeal cancers management. INTRODUCTION: A systematic review of literature was led searching for articles mentioning the following terms: advanced (T3-T4) laryngeal cancer AND laser; AND open partial laryngectomy; AND transoral laser microsurgery; AND cordectomy; AND conservative surgery; AND tracheohyoidopexy or tracheohyoidoepiglottopexy; AND supratracheal partial laryngectomy; AND supracricoid partial laryngectomy; AND cricohyoidopexy or cricohyoidoepiglottopexy...
November 8, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29118826/prevalence-of-hpv-infection-in-hypopharyngeal-and-laryngeal-squamous-cell-carcinoma-at-thailand-s-largest-tertiary-referral-center
#11
Warut Pongsapich, Nitathip Eakkasem, Sontana Siritantikorn, Paveena Pithuksurachai, Kshidej Bongsabhikul, Cheerasook Chongkolwatana
Background: Following the well-established relationship between human papillomavirus (HPV) and cervical carcinoma, the carcinogenicity of this virus has also been confirmed in subsets of head and neck carcinoma (HNCA), but mainly in the oropharynx. Other subsites of HNCA with less known association to HPV have never been studied in Thailand. Accordingly, the aim of this study was to investigate the prevalence of HPV DNA in hypopharyngeal and laryngeal squamous cell carcinoma in Thai population...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29116044/the-predictive-value-of-videostroboscopy-in-the-assessment-of-premalignant-lesions-and-early-glottis-cancers
#12
Anna Rzepakowska, Ewelina Sielska-Badurek, Ewa Osuch-Wójcikiewicz, Maria Sobol, Kazimierz Niemczyk
OBJECTIVE: To assess the sensitivity and specificity of larngovideostroboscopy (LVS) in the diagnosis of precancerous and malignant lesions of the vocal folds. MATERIAL AND METHODS: In 175 patients (128 men and 47 women), aged 19-88 years, mean age 61.5, who were admitted to the clinic with diagnosed premalignant conditions of vocal fold mucosa (leukoplakia, chronic hypertrophic inflammatory lesions) and thickening or tumor on the vocal fold, there was performed LVS before the laryngeal microsurgery...
August 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29112231/individualized-outcome-prognostication-for-patients-with-laryngeal-cancer
#13
Connor W Hoban, Lauren J Beesley, Emily L Bellile, Yilun Sun, Matthew E Spector, Gregory T Wolf, Jeremy M G Taylor, Andrew G Shuman
BACKGROUND: Accurate prognostication is essential to the optimal management of laryngeal cancer. Predictive models have been developed to calculate the risk of oncologic outcomes, but extensive external validation of accuracy and reliability is necessary before implementing them into clinical practice. METHOD: Four published prognostic calculators that predict 5-year overall survival for patients with laryngeal cancer were evaluated using patient information from a prospective epidemiology study cohort (n = 246; median follow-up, 60 months) with previously untreated, stage I through IVb laryngeal squamous cell carcinoma...
November 7, 2017: Cancer
https://www.readbyqxmd.com/read/29111339/combined-vocal-exercises-for-rehabilitation-after-supracricoid-laryngectomy-evaluation-of-different-execution-times
#14
Hevely Saray Lima Silveira, Marcia Simões-Zenari, Marco Aurélio Kulcsar, Claudio Roberto Cernea, Kátia Nemr
INTRODUCTION: The supracricoid partial laryngectomy allows the preservation of laryngeal functions with good local cancer control. OBJECTIVE: To assess laryngeal configuration and voice analysis data following the performance of a combination of two vocal exercises: the prolonged /b/vocal exercise combined with the vowel /e/ using chest and arm pushing with different durations among individuals who have undergone supracricoid laryngectomy. METHODS: Eleven patients undergoing partial laryngectomy supracricoid with cricohyoidoepiglottopexy (CHEP) were evaluated using voice recording...
October 27, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29108356/radiotherapy-for-t3n0-glottic-carcinoma-without-cord-fixation-elective-nodal-irradiation-or-not
#15
Ryo Toya, Ryuji Murakami, Daizo Murakami, Tetsuo Saito, Tomohiko Matsuyama, Yutaka Toya, Yasuyuki Yamashita, Natsuo Oya
Background: Although the T3 category has been changed in the sixth edition of the TNM staging system proposed by the Union for International Cancer Control (UICC), the appropriate clinical target volume (CTV) of elective nodal irradiation (ENI) for T3N0 glottic carcinoma without cord fixation, which was formerly treated as a T1-2N0 disease, is not fully discussed. Materials and Methods: We retrospectively analyzed 64 patients staged or restaged as T3N0 disease without cord fixation...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29108284/overexpression-of-mir-26b-decreases-the-cisplatin-resistance-in-laryngeal-cancer-by-targeting-atf2
#16
Linli Tian, Jiarui Zhang, Xiuxia Ren, Xinyu Liu, Wei Gao, Chen Zhang, Yanan Sun, Ming Liu
Cisplatin is a common used chemotherapeutic drug for the treatment of laryngeal cancer. However, drug-resistance is a major obstacle in platinum-based chemotherapy for laryngeal cancer. Recent studies have demonstrated that dysregulation of microRNAs (miRNAs) is responsible for chemoresistance in multiple cancers including laryngeal cancer, but the potential mechanisms are required to be explored. In the present study, we constantly exposed the laryngeal cancer cell line Hep-2 with cisplatin to establish a cisplatin-resistant laryngeal cancer cell model (Hep-2/R)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103744/a-high-ratio-of-il-12r%C3%AE-2-positive-tumor-infiltrating-lymphocytes-indicates-favorable-prognosis-in-laryngeal-cancer
#17
Ye Tao, Neil Gross, Yehai Liu, Liyong Zhang, Guojun Li, Zhigang Huang, Jianming Yang
BACKGROUND: The purpose of this study was to elucidate IL-12Rβ2's roles as a tumor-associated immunological molecule, delineate the complex roles of IL-12Rβ2(+) tumor-infiltrating lymphocytes (TILs) and tumor cell IL-12Rβ2 expression in the tumor microenvironment, and determine the correlation of IL-12Rβ2(+) TILs and tumor cell IL-12Rβ2 expression with clinical prognosis. METHODS: We assessed mRNA and protein levels in matched laryngeal cancer tissues (LTs) and adjacent normal mucous membrane tissues (ANMMTs) from 3 laryngeal cancer (LC) patients and ratios of IL-12Rβ2(+) TILs in matched LTs and ANMMTs from 61 LC patients...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29103742/percutaneous-endoscopic-gastrostomy-feeding-of-locally-advanced-oro-pharygo-laryngeal-cancer-patients-blenderized-or-commercial-food
#18
Pyrros Papakostas, Georgia Tsaousi, George Stavrou, Dimitrios Rachovitsas, Gavriil Tsiropoulos, Constantina Rova, Ioannis Konstantinidis, Antonios Michalopoulos, Vasilios Grosomanidis, Katerina Kotzampassi
OBJECTIVES: Head and neck cancer patients commonly suffer from severe malnutrition at the time of tentative diagnosis. Percutaneous Endoscopic Gastrostomy [PEG] feeding is now considered as an efficient tool to reduce nutritional deterioration alongside concurrent treatment. We undertook the challenge to retrospectively evaluate the impact of a commercial, disease-specific, feeding formula [Supportan, Fresenius Kabi, Hellas] versus blenderized family food on nutritional outcome. MATERIALS AND METHODS: This is a retrospective analysis of prospectively collected nutritional and anthropometric data at the time of PEG placement, at the 8th week [after treatment termination] and at 8 months [6mo of recovery from treatment]...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29102455/postsurgical-disfigurement-influences-disgust-recognition-a-case-control-study
#19
Quentin Lisan, Nathalie George, Stephane Hans, Ollivier Laccourreye, Cédric Lemogne
BACKGROUND: Little is known about how emotion recognition may be modified in individuals prone to elicit disgust. OBJECTIVE: We sought to determine if subjects with total laryngectomy would present a modified recognition of facial expressions of disgust. METHODS: A total of 29 patients presenting with a history of advanced-stage laryngeal cancer were recruited, 17 being surgically treated (total laryngectomy) and 12 treated with chemoradiation therapy only...
September 21, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29098272/adjuvant-external-beam-radiotherapy-in-locally-advanced-differentiated-thyroid-cancer
#20
Samantha Tam, Moran Amit, Mongkol Boonsripitayanon, Maria E Cabanillas, Naifa L Busaidy, G Brandon Gunn, Stephen Y Lai, Neil D Gross, Erich M Sturgis, Mark E Zafereo
Importance: As incidence of differentiated thyroid cancer rises, treatment paradigms have become increasingly defined. Despite this, locally advanced disease continues to be challenging to manage. Postoperative therapy in the form of radioactive iodine (RAI) is generally recommended, but the role of external beam radiation therapy (EBRT) is less well defined. Objective: To investigate the role of EBRT in locally advanced differentiated thyroid cancer. Design, Setting, and Participants: For this retrospective cohort study, patients treated surgically for T4a differentiated thyroid cancer at the University of Texas MD Anderson Cancer Center from January 2000 through December 2015 were recruited, and 88 patients were included for analysis...
November 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
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