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https://www.readbyqxmd.com/read/28323575/lung-laryngeal-and-other-respiratory-cancer-incidence-among-japanese-atomic-bomb-survivors-an-updated-analysis-from-1958-through-2009
#1
Elizabeth K Cahoon, Dale L Preston, Donald A Pierce, Eric Grant, Alina V Brenner, Kiyohiko Mabuchi, Mai Utada, Kotaro Ozasa
The Life Span Study (LSS) of Japanese atomic bomb survivors is comprised of a large, population-based cohort offering one of the best opportunities to study the relationship between exposure to radiation and incidence of respiratory cancers. Risks of lung, laryngeal and other cancers of the respiratory system were evaluated among 105,444 LSS subjects followed from 1958 to 2009. During this period, we identified 2,446 lung, 180 laryngeal and 115 other respiratory (trachea, mediastinum and other ill-defined sites) first primary incident cancer cases...
March 21, 2017: Radiation Research
https://www.readbyqxmd.com/read/28318164/-application-of-gastric-tube-interposition-by-touching-laryngeal-prominence-in-postoperative-oral-cancer-patients
#2
Guo Huan, Bi Xiaoqin
OBJECTIVE: This study explores the application of gastric tube interposition by touching laryngeal prominence in postoperative oral cancer patients. METHODS: This trial includes 66 patients treated in the West China Hospital of Stomatology from August 2014 to December 2014. These patients were randomly divided into two groups: the test group included 33 patients who underwent gastric tube interposition by touching laryngeal prominence; the 33 other patients, who served as control group, underwent regular gastric tube interposition...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28301268/efficacy-and-toxicity-profiles-of-two-chemoradiotherapies-for-stage-ii-laryngeal-cancer-a-comparison-between-late-course-accelerated-hyperfractionation-lcahf-and-conventional-fractionation-cf
#3
Eiichiro Okazaki, Naoki Matsushita, Mari Tashiro, Yasuhiko Shimatani, Kentaro Ishii, Masako Hosono, Masahiro Oishi, Yuichi Teranishi, Hiroyoshi Iguchi, Yukio Miki
OBJECTIVE: To evaluate the treatment results of late course accelerated hyperfractionation (LCAHF) compared with conventional fractionation (CF) for stage II laryngeal cancer. METHODS: Fifty-nine consecutive patients treated for stage II laryngeal cancer were retrospectively reviewed. Thirty-two patients underwent LCAHF, twice-daily fractions during the latter half with a total dose of 69 Gy. Twenty-seven patients received CF of 70 Gy. RESULTS: The local control rates (LCRs), overall survival (OS), and disease-specific survival (DSS) at 5 years were 80...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28301066/effect-of-daily-fraction-size-on-laryngoesophageal-dysfunction-after-chemoradiation-for-squamous-cell-carcinomas-of-the-larynx-and-hypopharynx
#4
Allen M Chen, Sophia Hsu, Jessica Meshman, Robert Chin, Philip Beron, Elliot Abemayor, Maie St John
BACKGROUND: The purpose of this study was to determine the effect of fraction size on laryngoesophageal dysfunction among patients treated by chemoradiotherapy for laryngeal and hypopharyngeal cancer. METHODS: Forty patients underwent chemoradiotherapy for stage III/IV squamous cell carcinomas of the larynx and hypopharynx. Median radiation dose was 70 Gy (range, 69.3-70.4 Gy) with daily fractionation ranging from 2 Gy to 2.2 Gy. RESULTS: When comparing 2 Gy versus >2 Gy daily fractionation, there was no difference in 2-year overall survival (71% vs 72%; p = ...
March 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/28295829/chondroradionecrosis-of-the-larynx-24-year-university-of-wisconsin-experience
#5
Thomas G Gessert, Christopher J Britt, Austin M W Maas, Aaron M Wieland, Paul M Harari, Gregory K Hartig
BACKGROUND: Chondroradionecrosis (CRN) is an uncommon but significant complication of laryngeal radiotherapy that presents a diagnostic challenge to clinicians through its similarity in presentation to cancer recurrence. METHODS: Two hundred ninety-four patients underwent primary, adjuvant, or salvage radiation for laryngeal cancer from 1991 to 2015 at the University of Wisconsin. Medical records were reviewed to identify and characterize patients with a diagnosis of CRN...
March 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28291932/online-dosimetric-evaluation-of-larynx-sbrt-a-pilot-study-to-assess-the-necessity-of-adaptive-replanning
#6
Weihua Mao, Timothy Rozario, Weiguo Lu, Xuejun Gu, Yulong Yan, Xun Jia, Baran Sumer, David L Schwartz
PURPOSE: We have initiated a multi-institutional phase I trial of 5-fraction stereotactic body radiotherapy (SBRT) for Stage III-IVa laryngeal cancer. We conducted this pilot dosimetric study to confirm potential utility of online adaptive replanning to preserve treatment quality. METHODS: We evaluated ten cases: five patients enrolled onto the current trial and five patients enrolled onto a separate phase I SBRT trial for early-stage glottic larynx cancer. Baseline SBRT treatment plans were generated per protocol...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28280511/combination-treatment-of-perioperative-rehabilitation-and-psychoeducation-undergoing-thoracic-surgery
#7
Kazuhiro Hayashi, Takayuki Inoue, Motoki Nagaya, Satoru Ito, Hiroki Nakajima, Keiko Hattori, Izumi Kadono, Kohei Yokoi, Yoshihiro Nishida
Postoperative pulmonary complications are a risk associated with thoracic surgery. However, there have been few reports on cases at high risk of postoperative complications. Cancer patients often have negative automatic thoughts about illness, and these negative automatic thoughts are associated with reduced health behavior and physical activity. This case series demonstrates the successful combination treatment of perioperative rehabilitation and psychoeducation for negative automatic thoughts in two cancer patients who underwent thoracic surgery...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28277333/voice-outcomes-for-early-laryngeal-cancer
#8
Andrew J Kinshuck, Aditya Shenoy, Terry M Jones
PURPOSE OF REVIEW: Treatment options for early laryngeal cancer are well established with good local control and 5-year survival. The commonest treatments are radiotherapy or transoral laser microsurgery (TLM). There are advantages and disadvantages of the different modalities, but debate continues regarding the voice outcomes posttreatment. This review will focus on early glottic carcinoma and voice outcomes following the different treatments. RECENT FINDINGS: TLM and radiotherapy are both likely to affect voice quality, but the extent of voice change depends on different factors...
March 8, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28276466/conditional-survival-analysis-of-patients-with-locally-advanced-laryngeal-cancer-construction-of-a-dynamic-risk-model-and-clinical-nomogram
#9
(no author information available yet)
Conditional survival (CS), the survival beyond a pre-defined time interval, can identify periods of higher mortality risk for patients with locally advanced laryngeal cancer who face treatment-related toxicity and comorbidities related to alcohol and smoking in the survivorship setting. Using Weibull regression modeling, we analyzed retrospectively abstracted data from 638 records of patients who received radiation to identify prognostic factors for overall survival (OS) and recurrence free survival (RFS) for the first 3 years of survival and for OS conditional upon 3 years of survival...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28272707/reduced-mir-300-expression-predicts-poor-prognosis-in-patients-with-laryngeal-squamous-cell-carcinoma
#10
F-Y He, H-J Liu, Q Guo, J-L Sheng
OBJECTIVE: miR-300 has been demonstrated to play an important role in the progression of several tumors, but its role in tumorigenesis of laryngeal squamous cell carcinoma (LSCC) is still unclear. The purpose of this study was to explore miR-300 expression in LSCC patients and analyze its association with clinicopathological factors and prognosis. PATIENTS AND METHODS: In the present study, we measured the expression level of miR-300 in LSCC tissues by RT-PCR. Associations between miRNA-300 expressions and various clinicopathological characteristics were analyzed...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28272002/the-possible-role-of-diabetes-in-the-etiology-of-laryngeal-cancer
#11
Roberto Menicagli, Gianni Bolla, Laura Menigcali, Anastassia Esseridou
BACKGROUND: Laryngeal cancer and oral cancer are not always correlated with genetic mutations, HPV infection, smoking, and alcohol abuse. In the absence of these risk factors, there is an increase on these cancers with a parallel increase of diabetes. The aim of this study is to verify if diabetes could be a risk factor for the laryngeal cancer. METHODS: A questionnaire was given to a group of ninety laryngectomees to verify if these patients have presented diabetes and xerostomia before surgery...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28270397/multiple-primary-malignancies-of-laryngeal-cancer-small-cell-lung-cancer-and-squamous-cell-lung-cancer-in-a-patient-how-to-approach-mpms
#12
Eun Kyoung Kim, Joo-Yeon Kim, Bo Mi Kim, Sung-Nam Lim
Lung malignancies presenting in association with head and neck cancers are well documented, while laryngeal cancers presenting with simultaneous small cell lung cancer and squamous cell lung cancer have been rarely reported. We report a case of a man aged 65 years with a triple primary malignancy of the lung and larynx. Without a meticulous approach, the patients may not receive curative aim treatment due to incomplete staging. The patient underwent concurrent chemoradiotherapy for locally advanced laryngeal cancer, small cell lung cancer and squamous cell lung cancer followed by combination chemotherapy with etoposide and cisplatin for synchronous double primary lung cancer...
March 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28268924/modeling-of-pharyngoesophageal-segment-during-tracheoesophageal-phonation-in-total-laryngectomy-patients-with-preliminary-validation
#13
Teng Zhang, Siwei Bai, Ian Cook, Michal Szczesniak, Julia Maclean, Socrates Dokos
For patients with large or recurrent laryngeal cancer, total laryngectomy surgery is usually performed. In the absence of a larynx, tracheoesophageal (TE) voice is the gold standard for alaryngeal phonation. The mechanisms underlying TE voice are unknown, but pharyngoesophageal (PE) segment vibration has been shown to play a key role. The aim of this study was to systematically explore the mechanics of PE segment vibration during TE phonation. A 2D axisymmetric finite-element model with two domains representing the air and PE wall was developed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266802/polydatin-inhibits-cell-proliferation-and-induces-apoptosis-in-laryngeal-cancer-and-hela-cells-via-suppression-of-the-pdgf-akt-signaling-pathway
#14
Haixia Li, Baoyuan Shi, Yanyun Li, Fengfang Yin
Polydatin (PD), a stilbene compound extracted from Polygonum cuspidatum, is suggested to possess anti-cancer activities, including inhibition of cell proliferation, cell cycle arrest, and induction of apoptosis. The platelet-derived growth factor (PDGF)/AKT signaling pathway plays complex roles in tumor suppression. However, the effect of PD on the PDGF/AKT signaling pathway in laryngeal cancer and HeLa cells has not been explored. MTT assay and flow cytometry showed that PD inhibited cell proliferation and induced apoptosis in Hep-2 and AMC-HN-8 cells...
March 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28266295/simultaneous-total-esophagectomy-and-anterior-mediastinal-tracheostomy-for-recurrent-laryngeal-cancer-extended-to-the-superior-mediastinum
#15
Marius Fodor, Marcel Cosgarea, Lucian Fodor
Recurrent laryngeal cancer has an incidence of 25-50% and a 23-35% fiveyear survival rate. Surgery is the best treatment in order to control local recurrence. Herein, we present our surgical strategy for a patient with a history of modified radical laryngectomy for laryngeal cancer and with recurrent tumor at the cervical tracheostomy site extended to the thoracic trachea and esophagus. The wide resection included the sternal manubrium, the upper thoracic trachea, the entire esophagus and the upper mediastinal lymph nodes...
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28263996/reproducibility-reliability-and-validity-of-population-based-administrative-health-data-for-the-assessment-of-cancer-non-related-comorbidities
#16
Camille Maringe, Helen Fowler, Bernard Rachet, Miguel Angel Luque-Fernandez
BACKGROUND: Patients with comorbidities do not receive optimal treatment for their cancer, leading to lower cancer survival. Information on individual comorbidities is not straightforward to derive from population-based administrative health datasets. We described the development of a reproducible algorithm to extract the individual Charlson index comorbidities from such data. We illustrated the algorithm with 1,789 laryngeal cancer patients diagnosed in England in 2013. We aimed to clearly set out and advocate the time-related assumptions specified in the algorithm by providing empirical evidence for them...
2017: PloS One
https://www.readbyqxmd.com/read/28261352/identification-and-characterization-of-cd133-cd44-cancer-stem-cells-from-human-laryngeal-squamous-cell-carcinoma-cell-lines
#17
Jue Wang, Yongyan Wu, Wei Gao, Fei Li, Yunfeng Bo, Meixia Zhu, Rong Fu, Qingqing Liu, Shuxin Wen, Binquan Wang
Background: Laryngeal squamous cell carcinoma ranks second among head and neck squamous-cell carcinomas. Cancer stem cells can support cancer growth and malignant behavior. Therefore, cancer stem cells isolated from laryngeal squamous cell carcinoma tissue could be used to investigate the initiation, progression, and treatment strategies of this cancer. Methods: We isolated CD133-CD44-, CD133-CD44+, CD133+CD44- and CD133+CD44+ cell populations from laryngeal squamous-cell carcinoma cell lines Hep2 and TU-177 by magnetic-activated cell sorting...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28259905/matrix-stiffness-regulates-the-proliferation-stemness-and-chemoresistance-of-laryngeal-squamous-cancer-cells
#18
Lian Hui, Jingru Zhang, Xiaoxu Ding, Xing Guo, Xuejun Jiang
Increasing evidence shows that matrix stiffness plays a critical role in affecting the phenotype and behavior of tumor cells. We report that matrix stiffness significantly regulated the proliferation and chemotherapeutic response of Hep-2 cells. Increasing substrate stiffness promotes the proliferation of Hep-2 cells. When cultured on soft gels, Hep-2 cells expressed higher level of stem cell markers. Following treatment with cisplatin or 5-FU, we observed reduced apoptosis in Hep-2 cells cultured on soft supports...
February 15, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28259450/modality-specific-target-definition-for-laryngeal-and-hypopharyngeal-cancer-on-fdg-pet-ct-and-mri
#19
Hans Ligtenberg, Elise Anne Jager, Joana Caldas-Magalhaes, Tim Schakel, Frank A Pameijer, Nicolien Kasperts, Stefan M Willems, Chris H J Terhaard, Cornelis P J Raaijmakers, Marielle E P Philippens
BACKGROUND AND PURPOSE: The goal of this study was to improve target definition by deriving modality-specific margins for clinical target volumes (CTV) for laryngeal and hypopharyngeal cancer on CT, MRI and 18-FDG-PET. MATERIAL AND METHODS: Twenty-five patients with T3/T4 laryngeal/hypopharyngeal cancer underwent CT, MRI and 18-FDG-PET scans before laryngectomy. HE-sections were obtained from the surgical specimen and tumor was delineated (tumorHE). The GTVs on CT and MRI were delineated in consensus...
March 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28253270/sbrt-for-early-stage-glottic-larynx-cancer-initial-clinical-outcomes-from-a-phase-i-clinical-trial
#20
David L Schwartz, Alan Sosa, Stephen G Chun, Chiuxiong Ding, Xian-Jin Xie, Lucien A Nedzi, Robert D Timmerman, Baran D Sumer
PURPOSE: To confirm safety and feasibility of hypofractionated SBRT for early-stage glottic laryngeal cancer. METHODS: Twenty consecutive patients with cTis-T2N0M0 carcinoma of glottic larynx were enrolled. Patients entered dose-fractionation cohorts of incrementally shorter bio-equivalent schedules starting with 50 Gy in 15 fractions (fx), followed by 45 Gy/10 fx and, finally, 42.5 Gy/5 fx. Maximum combined CTV-PTV expansion was limited to 5 mm. Patients were treated on a Model G5 Cyberknife (Accuray, Sunnyvale, CA)...
2017: PloS One
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