Eric Pautas, Jérémie Despres, Isabelle Peyron, Jean-Louis Golmard, Jennifer Grange, Nelly Koenig, Adeline Gouronnec, Nathalie Mitha, Virginie Siguret, Isabelle Gouin-Thibault
BACKGROUND: Vitamin K antagonist tablets are often split to fractionate the dose by elderly patients. We performed a study in order to assess the divisibility of one dosage strength of score-lined warfarin and of score-lined fluindione. METHODS: Due to a recent change in the pharmaceutical form of fluindione in order to improve the divisibility, the study was performed over 2 different periods (with the « old » and with the « new » pharmaceutical form). In each period, 10 patients mean aged 82 years, 10 relatives, 10 nurses, 10 medical doctors) were asked to split in half warfarin tablets (W2 1(st) period et W2 2(d) period) and fluindione tablets (F2 et F'2), and to split fluindione tablets into 4 fragments (F4 et F'4)...
June 2011: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement