keyword
Keywords warfarin information race or c...

warfarin information race or culture or ethnic

https://read.qxmd.com/read/38450585/balancing-fracture-risk-versus-risk-of-mortality-before-fracture-among-women-aged-80%C3%A2-years-or-older
#1
JOURNAL ARTICLE
John T Schousboe, Lisa Langsetmo, Howard A Fink, Deborah M Kado, Jane A Cauley, Brent C Taylor, Kristine E Ensrud
BACKGROUND: Most fractures occur in women aged ≥80 years but competing mortality unrelated to fracture may limit the benefit of osteoporosis drug therapy for some women in late life. Our primary aim was to develop separate prediction models for non-spine fracture (NSF) and mortality before fracture to identify subsets of women with varying fracture versus mortality risks. METHODS: Separate prediction models were developed for NSF and mortality before NSF for 4895 women aged ≥80 years enrolled in the Study of Osteoporotic Fractures (SOF) or the Health Aging and Body Composition (HABC) study...
March 7, 2024: Journal of the American Geriatrics Society
https://read.qxmd.com/read/38187513/the-association-between-non-clinically-apparent-liver-fibrosis-and-pulmonary-arterial-hypertension-in-hispanic-patients
#2
JOURNAL ARTICLE
M Ammar Kalas, Yacoub Khatab, Gian Galura, Haider Alkhateeb, Debabrata Mukherjee, Hernando Garcia, Marc Zuckerman, Nils Patrick Nickel
BACKGROUND: Pulmonary arterial hypertension (PAH) is a deadly cardiopulmonary disease with multi-organ involvement including impaired liver function. Liver dysfunction in PAH is poorly understood but significantly associated with morbidity and mortality. Hispanics have a significantly higher prevalence of non-alcoholic fatty liver disease (NAFLD) and evidence of more advanced disease in comparison to other ethnic groups. The clinical impact of NAFLD in Hispanic PAH patients is unknown...
December 2023: Cardiology Research
https://read.qxmd.com/read/38160291/la-gem-imputation-of-gene-expression-with-incorporation-of-local-ancestry
#3
JOURNAL ARTICLE
Mrinal Mishra, Layan Nahlawi, Yizhen Zhong, Tanima De, Guang Yang, Cristina Alarcon, Minoli A Perera
Gene imputation and TWAS have become a staple in the genomics medicine discovery space; helping to identify genes whose regulation effects may contribute to disease susceptibility. However, the cohorts on which these methods are built are overwhelmingly of European Ancestry. This means that the unique regulatory variation that exist in non-European populations, specifically African Ancestry populations, may not be included in the current models. Moreover, African Americans are an admixed population, with a mix of European and African segments within their genome...
2024: Pacific Symposium on Biocomputing
https://read.qxmd.com/read/37161313/computational-analysis-of-missense-variant-cyp4f2-3-v433m-in-association-with-human-cyp4f2-dysfunction-a-functional-and-structural-impact
#4
JOURNAL ARTICLE
Mahvash Farajzadeh-Dehkordi, Ladan Mafakher, Fatemeh Samiee-Rad, Babak Rahmani
BACKGROUND: Cytochrome P450 4F2 (CYP4F2) enzyme is a member of the CYP4 family responsible for the metabolism of fatty acids, therapeutic drugs, and signaling molecules such as arachidonic acid, tocopherols, and vitamin K. Several reports have demonstrated that the missense variant CYP4F2*3 (V433M) causes decreased activity of CYP4F2 and inter-individual variations in warfarin dose in different ethnic groups. However, the molecular pathogenicity mechanism of missense V433M in CYP4F2 at the atomic level has not yet been completely elucidated...
May 9, 2023: BMC molecular and cell biology
https://read.qxmd.com/read/37039974/evaluation-of-a-warfarin-dosing-algorithm-including-cyp2c9-vkorc1-and-cyp4f2-polymorphisms-and-non-genetic-determinants-for-the-iranian-population
#5
JOURNAL ARTICLE
Mahvash Farajzadeh-Dehkordi, Fatemeh Samiee-Rad, Seyed Saeed Farzam, Amir Javadi, Sara Cheraghi, Dariush Hamedi-Asl, Babak Rahmani
BACKGROUND: The response to warfarin, as an oral anticoagulant agent, varies widely among patients from different ethnic groups. In this study, we tried to ascertain and determine the relationship between non-genetic factors and genetic polymorphisms with warfarin therapy; we then proposed a new warfarin dosing prediction algorithm for the estimation of drug sensitivity and resistance in the Iranian population. METHODS: Overall, 200 warfarin-treated patients with stable doses were recruited, the demographic and clinical characteristics were documented, and genotyping was done using a sequencing assay...
April 11, 2023: Pharmacological Reports: PR
https://read.qxmd.com/read/36546564/comparison-of-maintenance-dose-predictions-by-warfarin-dosing-algorithms-based-on-chinese-and-western-patients
#6
JOURNAL ARTICLE
Jiexin Deng, Yi Wang, Xiaokang An
Warfarin has a long record of safe and effective clinical use, and it remains one of the most commonly prescribed drugs for the prevention and treatment of thromboembolic conditions even in the era of direct oral anticoagulants (DOACs). To address its large inter-individual variability and narrow therapeutic window, the Clinical Pharmacogenetics Implementation Consortium (CPIC) has recommended using pharmacogenetic dosing algorithms, such as the ones developed by the International Warfarin Pharmacogenetics Consortium (IWPC) and by Gage et al...
December 22, 2022: Journal of Clinical Pharmacology
https://read.qxmd.com/read/36004679/warfarin-pharmacogenomics-in-african-populations-the-importance-of-ethnicity-based-algorithms
#7
JOURNAL ARTICLE
Mwada Jallul, Inas Alhudiri, Laith Al-Eitan, Adam Elzagheid
Tweetable abstract It is well accepted that pharmacogenomics (PGx) information from Asia and Europe should not be applied to Africa. More work is needed on different ethnic groups to generate population-specific algorithms that can be used effectively and safely.
September 2022: Pharmacogenomics
https://read.qxmd.com/read/35818222/correlation-between-cyp2c9-gene-polymorphism-and-warfarin-dose-in-chinese-han-population-with-coronary-heart-disease
#8
JOURNAL ARTICLE
Qiyu Zuo, Li Li, Mingjing Zhong, Gengbiao Chen, Junhui Xio
This study aimed to explore the correlation between CYP2C9 gene polymorphism and warfarin dose in Chinese Han patients with coronary heart disease. The selection was made to the analysis of blood coagulation test of Chinese Han ethnic group, 200 cases of coronary heart disease patients as target group, the patients were satisfied taking warfarin INR target (in the range of 2.0 ~ 3.0), the other to select 200 cases proved by physical examination health as health group. The warfarin dose and the clinical laboratory INR after warfarin administration were taken, and the DNA of the patients was extracted and tested...
December 15, 2021: Cellular and Molecular Biology
https://read.qxmd.com/read/34834577/race-and-drug-toxicity-a-study-of-three-cardiovascular-drugs-with-strong-pharmacogenetic-recommendations
#9
JOURNAL ARTICLE
Travis J O'Brien, Kevin Fenton, Alfateh Sidahmed, April Barbour, Arthur F Harralson
The Clinical Pharmacogenetics Implementation Consortium (CPIC® ) establishes evidence-based guidelines for utilizing pharmacogenetic information for certain priority drugs. Warfarin, clopidogrel and simvastatin are cardiovascular drugs that carry strong prescribing guidance by CPIC. The respective pharmacogenes for each of these drugs exhibit considerable variability amongst different ethnic/ancestral/racial populations. Race and ethnicity are commonly employed as surrogate biomarkers in clinical practice and can be found in many prescribing guidelines...
November 18, 2021: Journal of Personalized Medicine
https://read.qxmd.com/read/34463969/prevalence-and-the-factors-associated-with-oral-anticoagulant-use-among-nursing-home-residents
#10
JOURNAL ARTICLE
Qiaoxi Chen, Kate Lapane, Anthony P Nunes, Jennifer Tjia, Julie Hugunin, Matthew Alcusky
WHAT IS KNOWN AND OBJECTIVE: Anticoagulants are indicated for treatment and prevention of several clinical conditions. Prior studies have examined anticoagulant utilization for specific indications and in community-dwelling populations. Decision-making regarding anticoagulant prescribing in the nursing home setting is particularly challenging because advanced age and clinical complexity places most residents at increased risk for adverse drug events. To estimate the prevalence of oral anticoagulant (OAC) use (overall, warfarin, direct oral anticoagulants (DOACs)) and identify factors associated with oral anticoagulant use among the general population of residents living in nursing homes...
August 31, 2021: Journal of Clinical Pharmacy and Therapeutics
https://read.qxmd.com/read/33837838/deciphering-genetic-variants-of-warfarin-metabolism-in-children-with-ventricular-assist-devices
#11
JOURNAL ARTICLE
Anwar Baban, Francesca G Iodice, Arianna Di Molfetta, Marianna Cicenia, Caterina Rizzo, Emanuele Agolini, Fabrizio Drago, Antonio Novelli, Luca Di Chiara, Giuseppina Testa, Antonio Amodeo
Warfarin is prescribed in patients with ventricular assist devices (VADs). Dosage depends on several factors including the underlying genotype. These include polymorphisms of genes encoding cytochrome P450 enzymes, the main ones being CYP2C9, VKORC1, and CYP4F2. The objectives of this study were to evaluate the prevalence of CY2CP9 1*2*3*, VKORC1, and CYP4F2 in children with VADs and the time to reach the target international normalized ratio. We performed a retrospective/prospective study in children with VADs...
June 2021: Pediatric Cardiology
https://read.qxmd.com/read/32677855/quality-of-oral-anticoagulation-control-in-chinese-patients-with-non-valvular-atrial-fibrillation-a-prospective-controlled-study
#12
JOURNAL ARTICLE
Yaqian Li, Jingjing Yu, Yun Kuang, Chengkun Wu, Liu Yang, Qiulian Fang, Qi Pei, Guoping Yang
Objective: The sex, age, medical history, treatment, tobacco use, race risk (SAMe-TT2 R2 ) Score; the sex, age, medical history, treatment, tobacco use, genotype combination (SAMe-TT2 G2 ) Score; and the so-called modified SAMe-TT2R2 scores have been proposed to predict the anticoagulation quality for patients with non-valvular atrial fibrillation (NVAF). The data from a prospective controlled study is used to validate the SAMe-TT2 R2 and SAMe-TT2 G2 scores in Chinese NVAF patients treated with warfarin and to evaluate the association of factors with time in therapeutic range (TTR) to predict the quality of oral anticoagulation control...
July 17, 2020: Current Medical Research and Opinion
https://read.qxmd.com/read/31989097/patient-experience-of-living-with-cancer-associated-thrombosis-in-canada-pelicanada
#13
JOURNAL ARTICLE
Simon Noble, Annmarie Nelson, Jill Scott, Anne Berger, Karen Schmidt, Parinita Swarnkar, Agnes Lee
Introduction: Previous research from the United Kingdom and Spain has identified several areas of unmet clinical and support need for cancer patients diagnosed with venous thromboembolism. It is not known whether such experiences are restricted to those countries health care systems and culture. We therefore evaluated patients' experience of cancer-associated thrombosis (CAT) within a Canadian setting. Methods: Purposive sampling of patients with CAT attending a regional thrombosis clinic in Vancouver was undertaken...
January 2020: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/31875763/racial-and-ethnic-differences-in-response-to-anticoagulation-a-review-of-the-literature
#14
JOURNAL ARTICLE
Caitlin M Gibson, Wei C Yuet
INTRODUCTION: Anticoagulants are among the most frequently prescribed medications in the United States. Racial and ethnic disparities in incidence and outcomes of thrombotic disorders are well-documented, but differences in response to anticoagulation are incompletely understood. OBJECTIVE: The objective of this review is to describe the impact of race and ethnicity on surrogate and clinical end points related to anticoagulation and discuss racial or ethnic considerations for prescribing anticoagulants...
December 26, 2019: Journal of Pharmacy Practice
https://read.qxmd.com/read/31368406/adme-pharmacogenetics-future-outlook-for-russia
#15
JOURNAL ARTICLE
Karin B Mirzaev, Denis S Fedorinov, Dmitry V Ivashchenko, Dmitry A Sychev
This systematic review reflects the results of pharmacogenetic studies in the Russian Federation aimed at studying the genes involved in the drug biotransformation system. The works of Russian researchers found by us are mostly devoted to microsomal liver oxidation enzymes (metabolism) and membrane transporter systems (absorption and excretion). This review presents population-ethnic and associative clinical studies on the genes of the CYP450 system, noncytochrome oxidation enzymes ( SULT1A1 , CES1 ), membrane transporter system genes ( ABCB1 , SLCO1B1 ) and warfarin biotransformation enzymes ( VKORC1 , GGCX )...
August 1, 2019: Pharmacogenomics
https://read.qxmd.com/read/31064211/pharmacogenetics-of-warfarin-in-a-diverse-patient-population
#16
MULTICENTER STUDY
May Mak, Carol Lam, Sandra J Pineda, Mimi Lou, Lilia Yang Xu, Christopher Meeks, Cindy Lin, Roslynn Stone, Kathy Rodgers, Gladys Mitani
INTRODUCTION: Many warfarin-related genotypes have shown to impact the average daily warfarin (ADW) dose requirements; however, information in non-Caucasian populations is limited. OBJECTIVES: To identify the frequencies of 4 warfarin-related gene polymorphisms in an ethnically diverse patient population and to examine their impact with other clinical variables on ADW dose requirements. METHODS: Patients were recruited from 2 anticoagulation clinics in the Los Angeles area...
November 2019: Journal of Cardiovascular Pharmacology and Therapeutics
https://read.qxmd.com/read/31016691/effect-of-warfarin-on-ischemic-stroke-bleeding-and-mortality-in-patients-with-atrial-fibrillation-receiving-peritoneal-dialysis
#17
JOURNAL ARTICLE
Derek Phan, Su-Jau Yang, Albert Y-J Shen, Ming-Sum Lee
BACKGROUND: There is limited information on the risks and benefits of anticoagulation in patients with atrial fibrillation receiving peritoneal dialysis. OBJECTIVE: The aim was to determine the risk of mortality, ischemic stroke, and bleeding associated with warfarin use in patients with atrial fibrillation receiving peritoneal dialysis. PATIENTS AND METHODS: This is a retrospective observational study of a multi-ethnic cohort of patients with atrial fibrillation receiving peritoneal dialysis in the United States...
October 2019: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://read.qxmd.com/read/30589990/pharmacogenomics-research-and-clinical-implementation-in-brazil
#18
REVIEW
Fernanda Rodrigues-Soares, Guilherme Suarez-Kurtz
We searched PubMed entries and the Lattes database of Brazilian Pharmacogenetics Network investigators, for pharmacogenetic/genomic (PGx) studies in the Brazilian population, focusing on the drugs and genes included in the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Warfarin was the most extensively studied drug in a PGx context: a genomewide association study targeting warfarin stable dose identified significant signals in VKORC1 and CYP2C9, several PGx dosing algorithms were developed based on these and other genes, and the implications of population admixture on extrapolation of dosing recommendations in the CPIC guidelines were examined...
May 2019: Basic & Clinical Pharmacology & Toxicology
https://read.qxmd.com/read/30484833/association-of-race-ethnicity-with-oral-anticoagulant-use-in-patients-with-atrial-fibrillation-findings-from-the-outcomes-registry-for-better-informed-treatment-of-atrial-fibrillation-ii
#19
JOURNAL ARTICLE
Utibe R Essien, DaJuanicia N Holmes, Larry R Jackson, Gregg C Fonarow, Kenneth W Mahaffey, James A Reiffel, Benjamin A Steinberg, Larry A Allen, Paul S Chan, James V Freeman, Rosalia G Blanco, Karen S Pieper, Jonathan P Piccini, Eric D Peterson, Daniel E Singer
Importance: Black and Hispanic patients are less likely than white patients to use oral anticoagulants for atrial fibrillation. Little is known about racial/ethnic differences in use of direct-acting oral anticoagulants (DOACs) for atrial fibrillation. Objective: To assess racial/ethnic differences in the use of oral anticoagulants, particularly DOACs, in patients with atrial fibrillation. Design, Setting, and Participants: This cohort study used data from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II, a prospective, US-based registry of outpatients with nontransient atrial fibrillation 21 years and older who were followed up from February 2013 to July 2016...
November 28, 2018: JAMA Cardiology
https://read.qxmd.com/read/30356105/frequencies-of-poor-metabolizer-alleles-of-12-pharmacogenomic-actionable-genes-in-punjabi-sikhs-of-indian-origin
#20
JOURNAL ARTICLE
Dharambir K Sanghera, Cynthia Bejar, Bishwa Sapkota, Gurpreet S Wander, Sarju Ralhan
Diversity in drug response is attributed to both genetic and non-genetic factors. However, there is paucity of pharmacogenetics information across ethnically and genetically diverse populations of India. Here, we have analyzed 21 SNPs from 12 pharmacogenomics genes in Punjabi Sikhs of Indian origin (N = 1,616), as part of the Sikh Diabetes Study (SDS). We compared the allele frequency of poor metabolism (PM) phenotype among Sikhs across other major global populations from the Exome Aggregation Consortium and 1000 Genomes...
October 24, 2018: Scientific Reports
keyword
keyword
78188
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.