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micronutrient deficiencies

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https://www.readbyqxmd.com/read/29025632/modifiers-of-the-effect-of-maternal-multiple-micronutrient-supplementation-on-stillbirth-birth-outcomes-and-infant-mortality-a-meta-analysis-of-individual-patient-data-from-17-randomised-trials-in-low-income-and-middle-income-countries
#1
Emily R Smith, Anuraj H Shankar, Lee S-F Wu, Said Aboud, Seth Adu-Afarwuah, Hasmot Ali, Rina Agustina, Shams Arifeen, Per Ashorn, Zulfiqar A Bhutta, Parul Christian, Delanjathan Devakumar, Kathryn G Dewey, Henrik Friis, Exnevia Gomo, Piyush Gupta, Pernille Kæstel, Patrick Kolsteren, Hermann Lanou, Kenneth Maleta, Aissa Mamadoultaibou, Gernard Msamanga, David Osrin, Lars-Åke Persson, Usha Ramakrishnan, Juan A Rivera, Arjumand Rizvi, H P S Sachdev, Willy Urassa, Keith P West, Noel Zagre, Lingxia Zeng, Zhonghai Zhu, Wafaie W Fawzi, Christopher R Sudfeld
BACKGROUND: Micronutrient deficiencies are common among women in low-income and middle-income countries. Data from randomised trials suggest that maternal multiple micronutrient supplementation decreases the risk of low birthweight and potentially improves other infant health outcomes. However, heterogeneity across studies suggests influence from effect modifiers. We aimed to identify individual-level modifiers of the effect of multiple micronutrient supplements on stillbirth, birth outcomes, and infant mortality in low-income and middle-income countries...
November 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29016959/low-boron-tolerance-strategies-involving-the-pectin-mediated-cell-wall-mechanical-properties-in-brassica-napus
#2
Ting Zhou, Yingpeng Hua, Baocai Zhang, Xiuqing Zhang, Yihua Zhou, Lei Shi, Fangsen Xu
Boron (B) is an essential micronutrient for the growth and development of plants. Oilseed rape (Brassica napus L.) is a staple oleaginous crop, which is greatly susceptible to B deficiency. Significant differences in the tolerance to low-B stresses are observed in rapeseed genotypes, whereas the underlying mechanism remains unclear, particularly at the single-cell level. Here, we provide novel insights into the pectin-mediated cell wall (CW) mechanical properties implicated in the differential tolerance to low-B in rapeseed genotypes...
September 15, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29016304/hair-mercury-level-is-associated-with-anemia-and-micronutrient-status-in-children-living-near-artisanal-and-small-scale-gold-mining-in-the-peruvian-amazon
#3
Caren Weinhouse, Ernesto J Ortiz, Axel J Berky, Paige Bullins, John Hare-Grogg, Laura Rogers, Ana-Maria Morales, Heileen Hsu-Kim, William K Pan
Anemia has been widely studied in global health contexts because of severe nutritional deficiency, and more recently, inflammatory status, but chemical exposures are rarely considered. Until recently, "anemia" was used synonymously with "iron deficiency anemia (IDA)" in global health settings. However, only 50% of anemia cases worldwide are IDA. Environmental toxicology studies of anemia risk have generally focused on populations in developed countries, albeit with high exposure to environmental toxicants, such as lead or cadmium...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28988580/development-prevention-and-treatment-of-alcohol-induced-organ-injury-the-role-of-nutrition
#4
Shirish Barve, Shao-Yu Chen, Irina Kirpich, Walter H Watson, Craig Mcclain
Alcohol and nutrition have the potential to interact at multiple levels. For example, heavy alcohol consumption can interfere with normal nutrition, resulting in overall malnutrition or in deficiencies of important micronutrients, such as zinc, by reducing their absorption or increasing their loss. Interactions between alcohol consumption and nutrition also can affect epigenetic regulation of gene expression by influencing multiple regulatory mechanisms, including methylation and acetylation of histone proteins and DNA...
2017: Alcohol Research: Current Reviews
https://www.readbyqxmd.com/read/28985688/diagnosis-and-management-of-pancreatic-exocrine-insufficiency-pei-in-primary-care-consensus-guidance-of-a-canadian-expert-panel
#5
P Durie, J-D Baillargeon, S Bouchard, F Donnellan, S Zepeda-Gomez, C Teshima
Pancreatic exocrine insufficiency (PEI) results in maldigestion due to inadequate activity of pancreatic enzymes in the small bowel. PEI can arise from a variety of medical conditions that reduce enzyme synthesis within the pancreatic parenchyma or from secondary factors that may occur despite optimal parenchymal function, such as pancreatic duct obstruction or reduced or poorly synchronized enzyme release. The most characteristic symptom of PEI is steatorrhea - voluminous, lipid-rich stools; other common signs and symptoms include unexplained weight loss and deficiencies of fat-soluble vitamins and other micronutrients...
October 6, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28982133/simultaneous-assessment-of-iodine-iron-vitamin-a-malarial-antigenemia-and-inflammation-status-biomarkers-via-a-multiplex-immunoassay-method-on-a-population-of-pregnant-women-from-niger
#6
Eleanor Brindle, Lorraine Lillis, Rebecca Barney, Sonja Y Hess, K Ryan Wessells, Césaire T Ouédraogo, Sara Stinca, Michael Kalnoky, Roger Peck, Abby Tyler, Christopher Lyman, David S Boyle
Deficiencies of vitamin A, iron, and iodine are major public health concerns in many low- and middle-income countries, but information on their status in populations is often lacking due to high costs and logistical challenges associated with assessing micronutrient status. Accurate, user-friendly, and low-cost analytical tools are needed to allow large-scale population surveys on micronutrient status. We present the expansion of a 7-plex protein microarray tool for the simultaneous measurement of up to seven biomarkers with relevance to the assessment of the key micronutrients iron, iodine, and vitamin A, and inflammation and malaria biomarkers: α-1-acid glycoprotein, C-reactive protein, ferritin, retinol binding protein 4, soluble transferrin receptor, thyroglobulin, and histidine-rich protein II...
2017: PloS One
https://www.readbyqxmd.com/read/28981457/micronutrient-status-and-dietary-intake-of-iron-vitamin-a-iodine-folate-and-zinc-in-women-of-reproductive-age-and-pregnant-women-in-ethiopia-kenya-nigeria-and-south-africa-a-systematic-review-of-data-from-2005-to-2015
#7
REVIEW
Rajwinder Harika, Mieke Faber, Folake Samuel, Judith Kimiywe, Afework Mulugeta, Ans Eilander
A systematic review was conducted to evaluate the status and intake of iron, vitamin A, iodine, folate and zinc in women of reproductive age (WRA) (≥15-49 years) and pregnant women (PW) in Ethiopia, Kenya, Nigeria and South Africa. National and subnational data published between 2005 and 2015 were searched via Medline, Scopus and national public health websites. Per micronutrient, relevant data were pooled into an average prevalence of deficiency, weighted by sample size (WAVG). Inadequate intakes were estimated from mean (SD) intakes...
October 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28978232/retail-sugar-from-one-zambian-community-does-not-meet-statutory-requirements-for-vitamin-a-fortification
#8
Matthew D Greene, Gladys Kabaghe, Mofu Musonda, Amanda C Palmer
BACKGROUND: Industrial food fortification is a major strategy to improve dietary micronutrient intakes and prevent deficiencies. Zambia introduced mandatory sugar fortification with vitamin A, at a target of 10 mg/kg, in 1998. Representative surveys conducted since that time do not support marked improvement in vitamin A status. OBJECTIVE: To describe vitamin A concentrations in retail sugar, as well as vendor practices, perceptions of fortified foods, and sugar use practices...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28971097/acceptability-of-iron-and-zinc-biofortified-pearl-millet-ictp-8203-based-complementary-foods-among-children-in-an-urban-slum-of-mumbai-india
#9
Samantha Lee Huey, Sudha Venkatramanan, Shobha A Udipi, Julia Leigh Finkelstein, Padmini Ghugre, Jere Douglas Haas, Varsha Thakker, Aparna Thorat, Ashwini Salvi, Anura V Kurpad, Saurabh Mehta
Biofortification, a method for increasing micronutrient content of staple crops, is a promising strategy for combating major global health problems, such as iron and zinc deficiency. We examined the acceptability of recipes prepared using iron- and zinc-biofortified pearl millet (FeZnPM) (~80 ppm Fe, ~34 ppm Zn, varietal ICTP-8203), compared to conventional pearl millet (CPM) (~20 ppm Fe, ~19 ppm Zn) in preparation for an efficacy trial. Our objective was to examine the acceptability of FeZnPM compared to CPM among young children and mothers living in the urban slums of Mumbai...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28969507/societal-costs-of-micronutrient-deficiencies-in-6-to-59-month-old-children-in-pakistan
#10
Simon Wieser, Beatrice Brunner, Christina Tzogiou, Rafael Plessow, Michael B Zimmermann, Jessica Farebrother, Sajid Soofi, Zaid Bhatti, Imran Ahmed, Zulfiqar A Bhutta
BACKGROUND: In Pakistan, nearly half of children younger than 5 years are stunted and 1 in 3 is underweight. Micronutrient deficiencies, a less visible form of undernutrition, are also endemic. They may lead to increased morbidity and mortality as well as to impaired cognitive and physical development. OBJECTIVE: To estimate the lifetime costs of micronutrient deficiencies in Pakistani children aged between 6 and 59 months. METHODS: We develop a health economic model of the lifetime health and cost consequences of iodine, iron, vitamin A, and zinc deficiencies...
January 1, 2017: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/28965167/laparoscopic-reversal-of-the-biliopancreatic-diversion-with-duodenal-switch-a-step-by-step-video-case
#11
Hamzeh M Halawani, Gintaras Antanavicius
BACKGROUND: Despite the success of the Biliopancreatic Diversion with Duodenal Switch procedure (BPD-DS) in weight loss and comorbidities resolution, reversal of BPD-DS is necessary in 0.2-0.6% of BPD-DS cases for vitamin, protein, and other micronutrient deficiencies. Different techniques are available to reverse the malabsorptive component of the BPD-DS. METHODS: A retrospective chart review for a 37-year-old female patient who presented with lower leg edema and signs of malnutrition 5 years after a BPD/DS...
September 30, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28960876/executive-summary-for-the-micronutrient-powders-consultation-lessons-learned-for-operational-guidance
#12
Christina Nyhus Dhillon, Danya Sarkar, Rolf Dw Klemm, Lynnette M Neufeld, Rahul Rawat, Alison Tumilowicz, Sorrel Ml Namaste
Iron deficiency anaemia is estimated to be the leading cause of years lived with disability among children. Young children's diets are often inadequate in iron and other micronutrients, and provision of essential vitamin and minerals has long been recommended. With the limited programmatic success of iron drop/syrup interventions, interest in micronutrient powders (MNP) has increased. MNP are a mixture of vitamins and minerals, enclosed in single-dose sachets, which are stirred into a child's portion of food immediately before consumption...
September 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28955080/burden-of-zinc-zn-deficiency-a-high-volume-clinical-laboratory-data-analysis
#13
Hafsa Majid, Shabnum Khawaja, Aysha Habib Khan, Imran Siddqui, Farooq Ghani, Lena Jafri
A cross-sectional survey was done at the Section of Chemical Pathology, Department of Pathology and Laboratory Medicine, AKUH, Karachi, to determine frequency of Zn deficiency, the second major micronutrient deficiency in developing countries, in subjects coming for investigations. Data of plasma Zn, from Jan 2013 to Dec 2014 was analyzed and deficiency was labeled at <65ug/dl. Total 469 subjects were tested for plasma Zn levels over the period of 24 months and complete information was available for 422 subjects, included in final analysis...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28951113/update-on-metabolism-and-nutrition-therapy-in-critically-ill-burn-patients
#14
E Moreira, G Burghi, W Manzanares
Major burn injury triggers severe oxidative stress, a systemic inflammatory response, and a persistent hypermetabolic and hypercatabolic state with secondary sarcopenia, multiorgan dysfunction, sepsis and an increased mortality risk. Calorie deficit, negative protein balance and antioxidant micronutrient deficiency after thermal injury have been associated to poor clinical outcomes. In this context, personalized nutrition therapy with early enteral feeding from the start of resuscitation are indicated. Over the last four decades, different nutritional and pharmacological interventions aimed at modulating the immune and metabolic responses have been evaluated...
September 23, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28946293/storage-conditions-and-packaging-greatly-affects-the-stability-of-fortified-wheat-flour-influence-on-vitamin-a-iron-zinc-and-oxidation
#15
Youna M Hemery, Arnaud Laillou, Laura Fontan, Vincent Jallier, Regina Moench-Pfanner, Jacques Berger, Sylvie Avallone
Micronutrient deficiencies result in irreversible physical and cognitive consequences. Fortification of flour is widely applied to address micronutrient deficiencies, but vitamin losses can occur during the storage of fortified products. This work aimed at assessing the combined influence of different factors on vitamin A retention and the oxidative status of wheat flours: storage duration (up to 6months), temperature during storage, relative humidity within storage facilities, type of packaging (oxygen-permeable or not), and premix composition (with or without ferrous sulphate)...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28940428/maternal-alcohol-use-and-nutrition-during-pregnancy-diet-and-anthropometry
#16
R Colin Carter, Marjanne Senekal, Neil C Dodge, Lori Bechard, Ernesta M Meintjes, Christopher D Molteno, Christopher Duggan, Joseph L Jacobson, Sandra W Jacobson
BACKGROUND: Despite known risks of prenatal nutritional deficiencies and studies documenting increased prevalence of poor dietary intake among non-pregnant alcohol abusers, the nutritional status of heavy drinking pregnant women remains largely unstudied. Animal models have found interactions between prenatal ethanol exposure and micronutrients, such as choline, folate, B12, and iron, and human studies have reported that lower maternal weight and body mass confer increased fetal alcohol-related risk...
September 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28933045/a-prospective-single-arm-trial-of-modified-long-biliopancreatic-and-short-alimentary-limbs-roux-en-y-gastric-bypass-in-type-2-diabetes-patients-with-mild-obesity
#17
Abdon José Murad, Ricardo Vitor Cohen, Eudes Paiva de Godoy, Christian Lamar Scheibe, Giuliano Peixoto Campelo, Almino Cardoso Ramos, Roclides Castro de Lima, Luís Eduardo Veras Pinto, Daniel Coelho, Hamilton Belo França Costa, Ígor Marreiros Pereira Pinto, Tiago Pereira, Francisco Raúl Santos Teófilo, José Aparecido Valadão
BACKGROUND: Type-2 diabetes (T2D) patients with body mass index (BMI) below 35 kg/m(2) carry lower remission rates than severely obese T2D individuals submitted to "standard limb lengths" Roux-en-Y gastric bypass (RYGB). Mild-obese patients appear to have more severe forms of T2D, where the mechanisms of glycemic control after a standard-RYGB may be insufficient. The elongation of the biliopancreatic limb may lead to greater stimulation of the distal intestine, alterations in bile acids and intestinal microbiota, among other mechanisms, leading to better metabolic outcomes...
September 20, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28932059/prevalence-of-nutritional-deficiencies-in-hair-loss-among-indian-participants-results-of-a-cross-sectional-study
#18
Dinesh Gowda, V Premalatha, D B Imtiyaz
BACKGROUND: Nutritional deficiencies are known to be associated with hair loss; however, the exact prevalence is not known. AIMS: The aim of this study is to evaluate the prevalence of nutritional deficiencies in participants with hair loss. MATERIALS AND METHODS: In this cross-sectional study, 100 enrolled participants were divided into telogen effluvium (TE), male-pattern hair loss (MPHL), and female-pattern hair loss (FPHL) based on the type of hair loss...
July 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28928514/component-analysis-of-nutritionally-rich-chloroplasts-recovery-from-conventional-and-unconventional-green-plant-species
#19
Mohamed A Gedi, Rhianna Briars, Felius Yuseli, Noorazwani Zainol, Randa Darwish, Andrew M Salter, David A Gray
A study of the literature indicates that chloroplasts synthesise a range of molecules, many of which have nutritional value for humans, but the nutritional credentials of chloroplasts recovered from plant cells are not established. Chloroplast-rich-fractions (CRFs) were prepared from green plant species and the macro- and micro-nutrient composition compared with the whole leaf materials (WLMs). The results indicated that, on a dry weight basis, CRF material from a range of green biomass was enriched in lipids and proteins, and in a range of micronutrients compared with the WLM...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28928244/selective-inhibitory-effects-of-zinc-on-cell-proliferation-in-esophageal-squamous-cell-carcinoma-through-orai1
#20
Sangyong Choi, Chaochu Cui, Yanhong Luo, Sun-Hee Kim, Jae-Kyun Ko, Xiaofang Huo, Jianjie Ma, Li-Wu Fu, Rhonda F Souza, Irina Korichneva, Zui Pan
Zinc, an essential micronutrient, has a cancer preventive role. Zinc deficiency has been shown to contribute to the progression of esophageal cancer. Orai1, a store-operated Ca(2+) entry (SOCE) channel, was previously reported to be highly expressed in tumor tissues removed from patients with esophageal squamous cell carcinoma (ESCC) with poor prognosis, and elevation of its expression contributes to both hyperactive intracellular Ca(2+) oscillations and fast cell proliferation in human ESCC cells. However, the molecular basis of cancer preventive functions of zinc and its association with Orai1-mediated cell proliferation remains unknown...
September 19, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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