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micronutrient deficiencies

Zexun Huai, Lishun Peng, Sheliang Wang, Hua Zhao, Lei Shi, Fangsen Xu
Boron (B) is an essential micronutrient of plants. In the present study, we characterized an Arabidopsis mutant lbt with significant l ow -b oron t olerance that was identified based on our previous mapping of QTL for B efficiency in Arabidopsis . Multiple nutrient-deficiency analyses point out that lbt mutant is insensitive to only B-limitation stress. Compared with wild-type Col-0, the fresh weight, leaf area, root length and root elongation rate of lbt mutant were significantly improved under B deficiency during vegetative growth...
2018: Frontiers in Plant Science
Paulien Vinke, Suzanne M Jansen, Renger F Witkamp, Klaske van Norren
Pulmonary arterial hypertension (PAH) is a progressive disease primarily affecting the pulmonary vasculature and heart. PAH patients suffer from exercise intolerance and fatigue, negatively affecting their quality of life. This review summarizes current insights in the pathophysiological mechanisms underlying PAH. It zooms in on the potential involvement of nutritional status and micronutrient deficiencies on PAH exercise intolerance and fatigue, also summarizing the potential benefits of exercise and nutritional interventions...
June 16, 2018: Heart Failure Reviews
Yan-Xiu Wang, Ya Hu, Yan-Fang Zhu, Abdul Wahid Baloch, Xu-Mei Jia, Ai-Xia Guo
BACKGROUND: Iron (Fe) is an essential micronutrient for plants. Utilization of Fe deficiency-tolerant rootstock is an effective strategy to prevent Fe deficiency problems in fruit trees production. Malus halliana is an apple rootstock that is resistant to Fe deficiency; however, few molecular studies have been conducted on M. halliana. RESULTS: To evaluate short-term molecular response of M. halliana leaves under Fe deficiency condition, RNA sequencing (RNA-Seq) analyses were conducted at 0 (T1), 0...
June 15, 2018: BMC Genomics
Susana L Matias, Malay K Mridha, Rebecca T Young, Md Showkat A Khan, Zakia Siddiqui, Md Barkat Ullah, Stephen A Vosti, Kathryn G Dewey
Background: Anemia, iron deficiency (ID), and iron deficiency anemia (IDA) among young children are public health concerns in developing countries. Objective: We evaluated the effects of small-quantity lipid-based nutrient supplements (LNSs) and micronutrient powder (MNP) on anemia, ID, and IDA in 18-mo-old Bangladeshi children. Methods: We enrolled 4011 pregnant women in a cluster-randomized effectiveness trial with 4 arms-1) LNS-LNS: LNSs (including 20 mg Fe) for women daily during pregnancy and 6 mo postpartum and LNSs (including 9 mg Fe) for children daily from 6 to 24 mo of age (LNS-C); 2) IFA-LNS: iron (60 mg) and folic acid (IFA) for women daily during pregnancy and every other day for 3 mo postpartum and LNS-C for children; 3) IFA-MNP: IFA for women, and MNP (including 10 mg Fe) for children daily from 6 to 24 mo; and 4) IFA-Control: IFA for women and no child supplement...
June 13, 2018: Journal of Nutrition
Svein Olav Kolset, Marianne Nordstrøm, Sigrun Hope, Kjetil Retterstøl, Per Ole Iversen
Persons with intellectual disabilities (ID) are dependent on nutritional policies that have so far not been addressed in a systematic and health-promoting manner in Norway and other nations with a high socioeconomic standard. In many poor countries, such issues have not even been raised nor addressed. Nutritional issues facing persons with ID include the risk of both underweight and overweight. Deficiency in energy, vitamins, essential fatty acids and micronutrients can increase the risk of additional health burdens in already highly vulnerable individuals...
2018: Food & Nutrition Research
Sonia L Robinson, Constanza Marín, Henry Oliveros, Mercedes Mora-Plazas, Blair J Richards, Betsy Lozoff, Eduardo Villamor
Background: Iron deficiency (ID) in infancy is related to subsequent behavior problems. The effects of micronutrient status in middle childhood are uncertain. Objective: The aim of the study was to examine the associations of micronutrient status biomarkers in middle childhood with externalizing and internalizing behavior problems in adolescence. Methods: We assessed whether ID (ferritin <15 µg/L), anemia (hemoglobin <12.7 g/dL), or blood concentrations of zinc, vitamins A and B-12, and folate at ages 5-12 y were associated with externalizing or internalizing behavior problems in adolescence in 1042 schoolchildren from Bogotá, Colombia...
April 20, 2018: Journal of Nutrition
Fiona L Mackie, Nicola S Cooper, Louise J Whitticase, Amanda Smith, William L Martin, Sheldon C Cooper
Adequate vitamin A is essential for healthy pregnancy, but high levels may be teratogenic. We present a patient who underwent bariatric surgery, prior to child bearing, and suffered maternal and foetal complications during eleven pregnancies, possibly associated with vitamin A deficiency, amongst multiple micronutrient deficiencies and risk factors including smoking and obesity. Maternal complications included visual disturbance, night blindness and recurrent infections. Recurrent foetal pulmonary hypoplasia and microphthalmia led to foetal and neonatal loss, not previously described in the medical literature...
June 12, 2018: European Journal of Clinical Nutrition
Valeria Candia, Israel Ríos-Castillo, Frank Carrera-Gil, Berta Vizcarra, Manuel Olivares, Sotiris Chaniotakis, Fernando Pizarro
INTRODUCTION: Micronutrient deficiencies are one of the most important public health issues worldwide and iron (Fe) deficiency anemia is the most prevalent micronutrient deficiency. Iron deficiency often coexists with calcium deficiency and iron and calcium supplementation often overlap. This has led to investigations into the interaction between these two minerals, and whether calcium may inhibit iron absorption in the gut. OBJECTIVE: To determine the effect of various calcium salts on non-heme iron bioavailability in fasted women of childbearing age...
September 2018: Journal of Trace Elements in Medicine and Biology
Shah Mohammad Fahim, Subhasish Das, Kazi Istiaque Sanin, Md Amran Gazi, Mustafa Mahfuz, M Munirul Islam, Tahmeed Ahmed
Environmental enteric dysfunction (EED) causes gut inflammation and increased intestinal permeability leading to deficiencies in micronutrients such as zinc and iron. Fecal markers such as myeloperoxidase (MPO), neopterin (NEO), and alpha-1-anti-trypsin (AAT) can predict EED. The aim of this study was to examine the association between fecal markers of EED with zinc and iron status among children at first 2 years of life. Malnutrition and Enteric Disease Study Bangladeshi birth cohort data were used to conduct this analysis...
June 11, 2018: American Journal of Tropical Medicine and Hygiene
Christian Wejse
The role of vitamin D in tuberculosis (TB) has been a hot topic for decades, and it is still an unresolved matter. Vitamin D deficiency and other micronutrient deficiencies have been considered as important risk factors for TB and malnutrition is overall a highly important risk factor for TB. In fact with the highest population attributable fraction (PAF) for TB at 27% (1), which means the fraction of all TB cases that would NOT have occurred if exposure (to e.g. malnutrition) was not there. This article is protected by copyright...
June 11, 2018: Journal of Internal Medicine
Rupak Shivakoti, Erin R Ewald, Nikhil Gupte, Wei-Teng Yang, Cecilia Kanyama, Sandra W Cardoso, Breno Santos, Khuanchai Supparatpinyo, Sharlaa Badal-Faesen, Javier R Lama, Umesh Lalloo, Fatima Zulu, Jyoti S Pawar, Cynthia Riviere, Nagalingeswaran Kumarasamy, James Hakim, Richard Pollard, Barbara Detrick, Ashwin Balagopal, David M Asmuth, Richard D Semba, Thomas B Campbell, Jonathan Golub, Amita Gupta
BACKGROUND & AIMS: Nutritional deficiency and inflammation may impact CD4+ T cell recovery during combination antiretroviral therapy (cART), particularly in resource-limited settings where malnutrition is prevalent. The aim of this study was to investigate the relationship of micronutrient and inflammation biomarkers to CD4 recovery after cART initiation. METHODS: We conducted a secondary analysis of a random sub-cohort sample (n = 270) from a multinational randomized trial of cART regimen efficacy among 1571 cART-naïve adults...
May 29, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Davide Giust, María Isabel Lucío, Afaf H El-Sagheer, Tom Brown, Lorraine E Williams, Otto L Muskens, Antonios G Kanaras
The development of innovative technologies to rapidly detect biomarkers associated with nutritional deficiencies in crops is highly relevant to agriculture and thus could impact the future of food security. Zinc (Zn) is an important micronutrient in plants, and deficiency leads to poor health, quality, and yield of crops. We have developed portable sensors, based on graphene oxide and upconversion nanoparticles, which could be used in the early detection of Zn deficiency in crops, sensing mRNAs encoding members of the ZIP-transporter family in crops...
June 6, 2018: ACS Nano
Ana Valea, Carmen Emanuela Georgescu
Selenium (Se) has a multilevel, complex and dynamic effect on the human body as a major component of selenocysteine, incorporated into selenoproteins, which include the selenocysteine-containing enzymes iodothyronine deiodinases. At the thyroid level, these proteins play an essential role in antioxidant protection and hormone metabolism. This is a narrative review based on PubMed/Medline database research regarding thyroid physiology and conditions with Se and Se-protein interferences. In humans, Se-dependent enzyme functions are best expressed through optimal Se intake, although there is gap in our knowledge concerning the precise mechanisms underlying the interrelation...
June 5, 2018: Hormones: International Journal of Endocrinology and Metabolism
Stuart D Portbury, Dominic J Hare, David P Bishop, David I Finkelstein, Philip A Doble, Paul A Adlard
Zinc (Zn) deficiency is a clinical consequence of brain injury that can result in neuropathological outcomes that are exacerbated with age. Here, we present laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging data showing modulation of brain Zn levels by the disaccharide trehalose in aged mice following a controlled cortical impact model of traumatic brain injury. In this proof-of-concept study, trehalose induced an increase in brain zinc levels, providing important preliminary data for larger studies using this simple carbohydrate as a modulator of this essential micronutrient in traumatic brain injury...
June 6, 2018: Metallomics: Integrated Biometal Science
M Campos Ponce, K Polman, N Roos, F T Wieringa, J Berger, C M Doak
Introduction Even though micronutrient deficiency is still a major public health problem, it is still unclear which interventions are most effective in improving micronutrient status. This review therefore aims to summarize the evidence published in systematic reviews on intervention strategies that aim at improving micronutrient status in children under the age of five. Methods We searched the literature and included systematic reviews that reported on micronutrient status as a primary outcome for children of 0-5 years old, had a focus on low or middle income countries...
June 4, 2018: Maternal and Child Health Journal
Douglas Siqueira Freitas, Bruna Wurr Rodak, André Rodrigues Dos Reis, Fabio de Barros Reis, Teotonio Soares de Carvalho, Joachim Schulze, Marco A Carbone Carneiro, Luiz R Guimarães Guilherme
Nickel (Ni)-a component of urease and hydrogenase-was the latest nutrient to be recognized as an essential element for plants. However, to date there are no records of Ni deficiency for annual species cultivated under field conditions, possibly because of the non-appearance of obvious and distinctive symptoms, i.e., a hidden (or latent) deficiency. Soybean, a crop cultivated on soils poor in extractable Ni, has a high dependence on biological nitrogen fixation (BNF), in which Ni plays a key role. Thus, we hypothesized that Ni fertilization in soybean genotypes results in a better nitrogen physiological function and in higher grain production due to the hidden deficiency of this micronutrient...
2018: Frontiers in Plant Science
Danielle Gordon, Michael Drescher, Shachaf Shiber
BACKGROUND: Medical treatment of hunger-strike patients, especially those in incarceration facilities, may pose clinical and treatment challenges for the treating physicians. OBJECTIVE: The aim of our study is to describe the epidemiology and clinical and laboratory characteristics of hunger-strike prisoners presenting to the emergency department (ED) and to describe etiologies of hospitalization and complications among this group. METHOD: We retrospectively examined clinical and laboratory manifestations of 50 hunger-strike prisoners who were referred for evaluation to the ED after a longstanding fast...
May 30, 2018: Journal of Emergency Medicine
Musarrat Riaz, Fareeha Shaikh, Asher Fawwad, Rubina Hakeem, A Samad Shera, Graham A Hitman, Bishwajit Bhowmik, Nayla Christina do Vale Moreira, Abdul Basit, Akhtar Hussain
Objective: To explore the impact of maternal body weight on maternal nutrition and micronutrient status in early pregnancy and potential impact on metabolic status in newborns. Methodology: The EU FP7 project GIFTS was conducted from Jan 2012 to May 2014. Demographic details and anthropometric measurements of women in the first trimester of pregnancy were obtained. Blood samples were collected for OGTT, insulin, lipid profile, serum folate, ferritin, vitamin D, vitamin B12, and red cell folate...
2018: Journal of Diabetes Research
Flávia Fernandes-Lima, Bianca M Gregório, Fernanda A M Nascimento, Waldemar S Costa, Carla B M Gallo, Francisco J B Sampaio
Vitamin D deficiency is common in pregnant women and infants. The present study aimed to investigate the effects of vitamin D restricted diet on the Wistar rats offspring penis morphology. Mother rats received either standard diet (SC) or vitamin D restricted (VitD) diet. At birth, offspring were divided into SC/SC (from SC mothers, fed with SC diet) and VitD/VitD (from VitD mothers, fed with VitD diet). After euthanasia the penises were processed for histomorphometric analysis. The VitD/VitD offspring displayed metabolic changes and reduction in the cross-sectional area of the penis, corpus cavernosum, tunica albuginea, and increased area of the corpus spongiosum...
2018: BioMed Research International
Jo-Anna B Baxter, Yaqub Wasan, Sajid B Soofi, Zamir Suhag, Zulfiqar A Bhutta
BACKGROUND: Adolescence is a critical period for physical and psychological growth and development, and vitamin and mineral requirements are correspondingly increased. Health and health behaviours correspond strongly from adolescence to adulthood. Developing a preconception care package for adolescent and young women in resource-limited settings could serve to empower them to make informed decisions about their nutrition, health, and well-being, as well as function as a platform for the delivery of basic nutrition-related interventions to address undernutrition...
May 30, 2018: Reproductive Health
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