keyword
https://read.qxmd.com/read/38464256/defining-the-t-cell-transcriptional-landscape-in-pediatric-liver-transplant-rejection-at-single-cell-resolution
#21
Anna L Peters, Erica A K DePasquale, Gousia Begum, Krishna M Roskin, E Steve Woodle, David A Hildeman
Acute cellular rejection (ACR) affects >80% of pediatric liver transplant recipients within 5 years, and late ACR is associated with graft failure. Traditional anti-rejection therapy for late ACR is ineffective and has remained unchanged for six decades. Although CD8+ T cells promote late ACR, little has been done to define their specificity and gene expression. Here, we used single-cell sequencing and immune repertoire profiling (10X Genomics) on 30 cryopreserved 16G liver biopsies from 14 patients (5 pre-transplant or with no ACR, 9 with ACR)...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38462861/outcomes-of-haematopoietic-stem-cell-transplantation-in-beta-thalassemia-major-with-fully-matched-parents-as-donor
#22
JOURNAL ARTICLE
Asghar Ali Kerio, Nighat Shahbaz, Tariq Azam Khattak, Tariq Ghafoor, Muhammad Farhan, Hashim Khan
OBJECTIVE: To determine the outcome of beta thalassemia major (BTM) patients undergoing haematopoietic stem cells (HSCT), with fully matched parents as donors vs. matched sibling donors (MSD). STUDY DESIGN: Observational Study. Place and Duration of the Study: Department of Clinical Haematology and Bone Marrow Transplantation Centre, Rawalpindi, Pakistan, from January 2013 to July 2023. METHODOLOGY: Group A consisted of BTM patients who underwent HSCT with fully matched siblings as donors, and Group B consisted of BTM patients who underwent HSCT with fully matched parents as donors...
March 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38460620/sex-specific-patterns-of-donor-derived-cell-free-dna-in-heart-transplant-rejection-an-analysis-from-the-genomic-research-alliance-for-transplantation-graft
#23
JOURNAL ARTICLE
Ersilia M DeFilippis, Benjamin Sweigart, Kiran K Khush, Palak Shah, Sean Agbor-Enoh, Hannah A Valantine, Amanda R Vest
INTRODUCTION: Non-invasive methods for surveillance of acute rejection are increasingly used in heart transplantation (HT), including donor-derived cell-free DNA (dd-cfDNA). As other cardiac biomarkers differ by sex, we hypothesized that there may be sex-specific differences in performance of dd-cfDNA for detection of acute rejection. The purpose of the current study was to examine patterns of dd-cfDNA seen in quiescence and acute rejection in males and female transplant recipients. METHODS: Patients enrolled in the Genomic Research Alliance for Transplantation (GRAfT) who were ≥18 years at the time of HT were included...
March 7, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38453157/experience-with-pembrolizumab-in-a-renal-transplant-patient-with-advanced-lung-cancer-a-case-report-and-review
#24
JOURNAL ARTICLE
Laura Fernández Madrigal, Victoria García Samblás, Laura Sánchez Escudero
The treatment of non-small cell lung cancer (NSCLC) has undergone a change because of the advancement of new therapies, like immune checkpoint inhibitors (ICIs), including pembrolizumab. A 64-year-old woman received a kidney transplant in 2012 because of chronic kidney disease secondary to glomerulosclerosis, diagnosed in 2020 with stage IV NSCLC because of metastasis in the contralateral lung, with programmed death ligand 1programmed death ligand 1 expression of 98%, starting treatment with ICIs, despite presenting a graft rejection risk around 40%...
March 8, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38450843/the-effect-of-primary-renal-disease-upon-outcomes-after-renal-transplant
#25
JOURNAL ARTICLE
Shona Garland, Kairi Pullerits, Chukwuma A Chukwu, Rajkumar Chinnadurai, Rachel Middleton, Philip A Kalra
BACKGROUND: This study investigated whether nature of primary renal disease affects clinical outcomes after renal transplantation at a single center in the United Kingdom. METHODS: This was a retrospective cohort study of 961 renal transplant recipients followed up at a large renal center from 2000 to 2020. Separation of diseases responsible for end-stage kidney disease included glomerulonephritis, diabetic kidney disease, hypertensive nephropathy, autosomal dominant polycystic kidney disease, unknown cause, other causes and chronic pyelonephritis...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38450290/basics-and-art-of-immunosuppression-in-liver-transplantation
#26
REVIEW
Shekhar Poudel, Subhash Gupta, Sanjiv Saigal
Liver transplantation is one of the most challenging areas in the medical field. Despite that, it has already been established as a standard treatment option, especially in decompensated cirrhosis and selected cases of hepatocellular carcinoma and acute liver failure. Complications due to graft rejection, including mortality and morbidity, have greatly improved over time due to better immunosuppressive agents and management protocols. Currently, immunosuppression in liver transplant patients makes use of the best possible combinations of effective agents to achieve optimal immunosuppression for long-term graft survival...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38449096/avascular-necrosis-in-kidney-transplant-recipients-is-associated-with-an-increased-risk-of-patient-death
#27
JOURNAL ARTICLE
Sonam Dolma, Fauzia Osman, Emily Zona, Angelie Santos, Fahad Aziz, Neetika Garg, Maha Mohamed, Didier Mandelbrot, Sandesh Parajuli
Introduction: Avascular necrosis is a debilitating osseous complication in transplant recipients. Project Aim: This program evaluation sought to describe risk factors and adverse outcomes of avascular necrosis in kidney transplant recipients. Design: This was a retrospective evaluation of all recipients of kidneys and simultaneous pancreas and kidneys between 2001 and 2018 from a single center. Controls were selected based on the incidence density, sampling at a 1:3 ratio based on the post-transplant interval...
March 6, 2024: Progress in Transplantation
https://read.qxmd.com/read/38447886/tissue-resident-memory-t-cells-in-human-kidney-transplants-have-alloreactive-potential
#28
JOURNAL ARTICLE
Daphne M Hullegie-Peelen, Hector Tejeda-Mora, Marjolein Dieterich, Sebastiaan Heidt, Eric M J Bindels, Martin J Hoogduijn, Dennis A Hesselink, Carla C Baan
The extent to which tissue-resident memory T (TRM ) cells in transplanted organs possess alloreactivity is uncertain. This study investigates the alloreactive potential of TRM cells in kidney explants from four patients who experienced severe acute rejection leading to graft loss. Alloreactive T cell receptor (TCRs) clones were identified in pre-transplant blood samples through mixed lymphocyte reactions, followed by single-cell RNA and TCR sequencing of the proliferated recipient T cells. Subsequently, these TCR clones were traced in the TRM cells of kidney explants, which were also subjected to single-cell RNA and TCR sequencing...
March 4, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38446250/transplant-nephrectomy-indication-surgical-approach-and-complications-experiences-from-a-single-transplantation-center
#29
JOURNAL ARTICLE
Josef Mang, Josephine Haag, Lutz Liefeldt, Klemens Budde, Robert Peters, Sebastian L Hofbauer, Matthias Schulz, Sarah Weinberger, Julia Dagnæs-Hansen, Andreas Maxeiner, Bernhard Ralla, Frank Friedersdorff
PURPOSE: Management of a failed kidney allograft, and the question whether it should be removed is a challenging task for clinicians. The reported risks for transplant nephrectomy (TN) vary, and there is no clear recommendation on indications or surgical approach that should be used. This study gives an overview of indications, compares surgical techniques, and identifies risk factors for higher morbidity. METHODS: Retrospective analysis was conducted on all transplant nephrectomies performed between 2005 and 2020 at Charité Hospital Berlin, Department of Urology...
March 6, 2024: World Journal of Urology
https://read.qxmd.com/read/38436082/co-transplantation-of-umbilical-cord-mesenchymal-stem-cells-and-peripheral-blood-stem-cells-in-children-and-adolescents-with-refractory-or-relapsed-severe-aplastic-anemia
#30
JOURNAL ARTICLE
Fangfang Yuan, Minghui Li, Xudong Wei, Yuewen Fu
To evaluate the co-transplantation efficacy of umbilical cord mesenchymal stem cells (UC-MSCs) and peripheral blood stem cells (PBSCs) as a novel approach for refractory or relapsed severe aplastic anemia (R/R SAA) in children and adolescents, thirty-two children and adolescents diagnosed with R/R SAA underwent a retrospective chart review. The patients were categorized into two groups based on the source of PBSCs: the matched sibling donor (MSD) group and the unrelated donor (UD) group. No adverse events related to UC-MSC infusion occurred in any of the patients...
March 4, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38432149/toll-like-receptor-2-deficiency-promotes-the-generation-of-alloreactive-%C3%AE-%C3%AE-t17-cells-after-cardiac-transplantation-in-mice
#31
JOURNAL ARTICLE
Lingyun Li, Chenyu Le, Wenfei Liu, Hongchen Zhang, Xiangyu Chen, Jianfeng Yang, Min Fang, Xiaofeng Zhang
Homograft rejection is the main cause of heart transplantation failure. The role of TLR2, a major member of the toll-like receptor (TLR) family, in transplantation rejection is has yet to be elucidated. In this study, we used a mouse model of acute cardiac transplantation rejection to investigate whether the TLR2 signalling pathway can regulate cardiac transplantation rejection by regulating alloreactive IL-17+ γδT (γδT17) cells. We found that the expression of TLR2 on the surface of dendritic cells (DCs) and macrophages increased during acute transplantation rejection...
March 2, 2024: International Immunopharmacology
https://read.qxmd.com/read/38430078/two-novel-assays-demonstrate-persistent-daratumumab-exposure-in-a-pediatric-patient-with-delayed-engraftment-following-allogeneic-hematopoietic-stem-cell-transplantation
#32
JOURNAL ARTICLE
Hannah Major-Monfried, Kinga Hosszu, Devin P McAvoy, Alexander Vallone, Neerav Shukla, Alfred Gillio, Barbara Spitzer, Andrew L Kung, Maria Cancio, Kevin Curran, Andromachi Scaradavou, Joseph H Oved, Richard J O'Reilly, Jaap Jan Boelens, Andrew C Harris
BACKGROUND AIMS: Daratumumab, a human IgG monoclonal antibody targeting CD38, is a promising treatment for pediatric patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL). We describe a case of delayed engraftment following a mismatched, unrelated donor hematopoietic stem cell transplant (HSCT) in a 14-year-old female with relapsed T-ALL, treated with daratumumab and chemotherapy. By Day 28 post-HSCT, the patient had no neutrophil engraftment but full donor myeloid chimerism...
February 29, 2024: Cytotherapy
https://read.qxmd.com/read/38419149/basiliximab-induction-and-postoperative-steroid-free-immunosuppression-with-tacrolimus-in-pediatric-liver-transplantation-a-randomized-clinical-trial
#33
JOURNAL ARTICLE
Chong Dong, Zhuolun Song, Chao Sun, Kai Wang, Wei Zhang, Jing Chen, Weiping Zheng, Yang Yang, Zhen Wang, Chao Han, Lijun Jiao, Guofeng Zhang, Enbo Xie, Wei Gao, Zhongyang Shen
BACKGROUND: Optimizing the immunosuppressive regimen is essential to improve the long-term outcomes of pediatric liver transplant recipients. METHODS: We conducted a prospective, randomized, open-label study to compare the safety and efficacy of 2 treatment approaches during pediatric liver transplantation: tacrolimus monotherapy following basiliximab induction (the study group) and a dual regimen of tacrolimus plus steroids (the control group). A total of 150 patients were enrolled, with 75 patients allocated to each group...
February 29, 2024: Transplantation
https://read.qxmd.com/read/38418315/including-the-liver-in-the-visceral-allograft-impact-on-donor-specific-anti-hla-antibodies-and-long-term-outcomes
#34
JOURNAL ARTICLE
Dace Abele, Markus Gäbel, Mihai Oltean, Jonas Varkey, Johan Mölne, Nils Ekwall, Helena Borg, Hanna Jacobsson, Jan Holgersson, Gustaf Herlenius
Humoral immunity emerges as a risk factor for graft failure after visceral transplantation (VTx) and development of donor-specific anti-HLA antibodies (DSAs) has been linked with poor outcomes. In most cases, a simultaneous liver transplant can be safely performed in sensitized patients with DSA and appears protective against lymphocytotoxic antibodies. We investigated the incidence of acute (AR) and chronic rejection (CR) in 32 VTx without any B cell-depleting pre-treatment (6 isolated intestinal transplants (IT) and 26 liver-containing, multivisceral transplants (MVT) and assessed the presence of donor-specific antibodies (DSA) pre- and post-transplantation...
February 27, 2024: Human Immunology
https://read.qxmd.com/read/38417629/outcomes-of-liver-transplantation-for-hepatocellular-carcinoma-in-donation-after-circulatory-death-compared-with-donation-after-brain-death-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Abdulahad Abdulrab Mohammed Al-Ameri, Shusen Zheng
INTRODUCTION AND OBJECTIVES: Due to organ shortages, liver transplantation (LT) using donation-after-circulatory-death (DCD) grafts has become more common. There is limited and conflicting evidence on LT outcomes using DCD grafts compared to those using donation-after-brain death (DBD) grafts for patients with hepatocellular carcinoma (HCC). We aimed to summarize the current evidence on the outcomes of DCD-LT and DBD-LT in patients with HCC. MATERIALS AND METHODS: Online databases were searched for studies comparing DCD-LT and DBD-LT outcomes in patients with HCC and a meta-analysis was conducted using fixed- or random-effects models...
February 27, 2024: Annals of Hepatology
https://read.qxmd.com/read/38415731/-renal-xenotransplantation-state-of-the-art
#36
JOURNAL ARTICLE
Marine Nachit, Grégoire Masson, Fadi Haidar, Sophie De Seigneux
Xenotransplantation could be an inexhaustible source of organs and change the life of end-stage kidney disease patients with reduction of morbidity and mortality. Through genetic engineering it is now possible to reduce the risk of hyperacute and acute graft rejection and improve the overall immune compatibility between two different species. Some experiments have already brought promising perspectives. Nevertheless, there are still difficulties to overcome. The risk of animal-related infectious diseases, ethnic limitations, safety, and applicability of large-scale xenotransplantation should be assessed...
February 28, 2024: Revue Médicale Suisse
https://read.qxmd.com/read/38414976/enhanced-donor-antigen-presentation-by-b-cells-predicts-acute-cellular-rejection-and-late-outcomes-after-transplantation
#37
JOURNAL ARTICLE
Chethan Ashokkumar, Mylarappa Ningappa, Vikram Raghu, George Mazariegos, Brandon W Higgs, Paul Morgan, Lisa Remaley, Tamara Fazzolare Martin, Pamela Holzer, Kevin Trostle, Qingyong Xu, Adriana Zeevi, James Squires, Kyle Soltys, Simon Horslen, Ajai Khanna, Armando Ganoza, Rakesh Sindhi
BACKGROUND: Enhanced B-cell presentation of donor alloantigen relative to presentation of HLA-mismatched reference alloantigen is associated with acute cellular rejection (ACR), when expressed as a ratio called the antigen presenting index (API) in an exploratory cohort of liver and intestine transplant (LT and IT) recipients. METHODS: To test clinical performance, we measured the API using the previously described 6-h assay in 84 LT and 54 IT recipients with median age 3...
March 2024: Transplantation Direct
https://read.qxmd.com/read/38413307/outcomes-of-kidney-transplantation-among-covid-19-recovered-patients-in-a-single-transplant-center
#38
JOURNAL ARTICLE
Krystal C Cervantes, Romina A Danguilan, Mel-Hatra I Arakama, Eric Chua, Cybele Lara R Abad, Rose Marie O Rosete-Liquete
BACKGROUND: The COVID-19 pandemic significantly lowered kidney transplantation (KT) rates worldwide, and studies regarding outcomes of patients who developed COVID-19 infection before KT are limited, especially in low to middle-income countries. BACKGROUND: To determine the 1-year graft and patient survival of kidney transplant recipients who recovered from COVID-19 infection before KT. METHODS: We retrospectively reviewed all adult end-stage renal disease patients who underwent KT at the National Kidney and Transplant Institute from June 2020 through October 2021...
February 26, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38409686/what-are-risk-factors-for-graft-loss-in-patients-who-underwent-simultaneous-splenectomy-during-living-donor-liver-transplantation
#39
JOURNAL ARTICLE
Takeo Toshima, Noboru Harada, Shinji Itoh, Takahiro Tomiyama, Katsuya Toshida, Kazutoyo Morita, Yoshihiro Nagao, Takeshi Kurihara, Takahiro Tomino, Yukiko Kosai-Fujimoto, Koshi Mimori, Tomoharu Yoshizumi
BACKGROUND: The consensus that portal venous pressure modulation, including splenectomy (Spx), prevents portal hypertension-related complications after living-donor liver transplantation (LDLT) has been established. However, little evidence about the risk factors for graft loss after simultaneous Spx during LDLT is available. This study aimed to identify the independent predictors of graft loss after simultaneous Spx during LDLT. METHODS: Data of 655 recipients who underwent LDLT between 1997 and 2021 were collected and separated into the simultaneous Spx group (n = 461) and no-Spx group (n = 194)...
February 27, 2024: Transplantation
https://read.qxmd.com/read/38400672/peri-operative-and-long-term-outcomes-of-kidney-transplantation-in-patients-with-cystic-fibrosis
#40
JOURNAL ARTICLE
John A O'Kelly, Fatimah Alaya, Niall F Davis, Dilly Little, Ponnusamy Mohan
INTRODUCTION: There is a lack of data regarding the peri-operative and long-term outcomes of kidney transplantation in cystic fibrosis (CF) patients. Herein, we report the peri-operative and long-term outcomes of kidney transplantation in CF patients. MATERIALS AND METHODS: All CF patients who received a kidney transplant at the national kidney transplant center between 1993 and 2022 were identified. Recipients of the contralateral donor kidney were selected as a control group...
February 2024: Clinical Transplantation
keyword
keyword
78179
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.